Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	GOLGA6L	GOLGA6L10 GOLGA6L19 GOLGA6L9 GOLGA6L4	5.26e-10	6	47	4	IPR026737
Domain	GOLGA2L5	GOLGA6L10 GOLGA6L19 GOLGA6L9 GOLGA6L4	1.05e-07	18	47	4	PF15070
Domain	Golgin_A	GOLGA6L10 GOLGA6L19 GOLGA6L9 GOLGA6L4	1.05e-07	18	47	4	IPR024858
Domain	Ribosomal_L22e	RPL22 RPL22L1	6.20e-06	2	47	2	IPR002671
Domain	Ribosomal_L22e	RPL22 RPL22L1	6.20e-06	2	47	2	PF01776
Domain	BROMODOMAIN_1	BRDT ATAD2	3.90e-03	37	47	2	PS00633
Domain	Bromodomain	BRDT ATAD2	4.11e-03	38	47	2	PF00439
Domain	BROMODOMAIN_2	BRDT ATAD2	4.77e-03	41	47	2	PS50014
Domain	SCY	CCL20 CXCL12	5.01e-03	42	47	2	SM00199
Domain	BROMO	BRDT ATAD2	5.01e-03	42	47	2	SM00297
Domain	Bromodomain	BRDT ATAD2	5.01e-03	42	47	2	IPR001487
Domain	-	BRDT ATAD2	5.01e-03	42	47	2	1.20.920.10
Domain	IL8	CCL20 CXCL12	5.48e-03	44	47	2	PF00048
Domain	Chemokine_IL8-like_dom	CCL20 CXCL12	5.48e-03	44	47	2	IPR001811
Domain	TPR-contain_dom	IFIT5 FKBP4 EDRF1	6.36e-03	150	47	3	IPR013026
Domain	TPR_2	IFIT5 FKBP4	7.03e-03	50	47	2	PF07719
Domain	TPR_2	IFIT5 FKBP4	7.03e-03	50	47	2	IPR013105
Domain	TPR	IFIT5 FKBP4 EDRF1	8.26e-03	165	47	3	PS50005
Domain	TPR_REGION	IFIT5 FKBP4 EDRF1	8.26e-03	165	47	3	PS50293
Pubmed	CXCL12 and CCL20 play a significant role in mucosal T-lymphocyte adherence to intestinal microvessels in mice.	CCL20 CXCL12	1.94e-06	2	49	2	17885999
Pubmed	RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.	RPL22 RPL22L1	1.94e-06	2	49	2	31581233
Pubmed	Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1{alpha}.	AGTR1 CXCL12	1.94e-06	2	49	2	19834109
Pubmed	The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.	RPL22 RPL22L1	1.94e-06	2	49	2	23990801
Pubmed	JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia.	JAK2 CXCL12	1.94e-06	2	49	2	26413812
Pubmed	Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.	JAK2 CXCL12	5.83e-06	3	49	2	23526587
Pubmed	Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.	JAK2 AGTR1	5.83e-06	3	49	2	7746328
Pubmed	CXCL12 signaling is independent of Jak2 and Jak3.	JAK2 CXCL12	5.83e-06	3	49	2	15611059
Pubmed	BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially.	CCL20 CXCL12	5.83e-06	3	49	2	11877260
Pubmed	The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.	JAK2 AGTR1	5.83e-06	3	49	2	11152457
Pubmed	Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.	JAK2 AGTR1	1.16e-05	4	49	2	22613986
Pubmed	Effect and mechanism of miR-135a-5p/CXCL12/JAK-STAT axis on inflammatory response after myocardial infarction.	JAK2 CXCL12	1.16e-05	4	49	2	33378042
Pubmed	Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.	RPL22 RPL22L1	1.16e-05	4	49	2	28076796
Pubmed	Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer.	JAK2 CXCL12	1.16e-05	4	49	2	25310198
Pubmed	Hmga2 promotes the development of myelofibrosis in Jak2V617F knockin mice by enhancing TGF-β1 and Cxcl12 pathways.	JAK2 CXCL12	1.16e-05	4	49	2	28637665
Pubmed	Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.	RPL22 RPL22L1	2.91e-05	6	49	2	35046107
Pubmed	4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.	JAK2 HERC5	4.07e-05	7	49	2	36575176
Pubmed	Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells.	OAS3 CCL20 HERC5	5.86e-05	53	49	3	26116899
Pubmed	Analysis of the DNA sequence and duplication history of human chromosome 15.	GOLGA6L10 GOLGA6L19 GOLGA6L4	6.91e-05	56	49	3	16572171
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	IFIT5 OAS3 MRPL40 HERC5	7.97e-05	161	49	4	32572027
Pubmed	Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes.	CCL20 CXCL12	8.69e-05	10	49	2	15381731
Pubmed	Versican interacts with chemokines and modulates cellular responses.	CCL20 CXCL12	1.06e-04	11	49	2	11083865
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	MRPL40 CLINT1 RPL22L1 RTN1 FKBP4 CXCL12	1.29e-04	558	49	6	35063084
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	RPL22 BRDT ATAD2	1.65e-04	75	49	3	25593309
Pubmed	Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone.	DLX4 CXCL12	1.75e-04	14	49	2	17182777
Pubmed	HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21.	CCL20 CXCL12	1.75e-04	14	49	2	15972662
Pubmed	Genome-wide association study link novel loci to endometriosis.	PDE1C VEZT	3.27e-04	19	49	2	23472165
Pubmed	CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.	CCL20 CXCL12	3.64e-04	20	49	2	23620790
Pubmed	Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.	CCL20 CXCL12	4.01e-04	21	49	2	12949249
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	NAE1 SHPRH IFIT5 MRPL40 CLINT1 RPL22L1 MPND	4.91e-04	1005	49	7	19615732
Pubmed	Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).	RPL22 PRPF19	7.18e-04	28	49	2	22178446
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NBAS VEZT NAE1 PRPF19 MRPL40 FKBP4 EDRF1 HERC5	1.04e-03	1487	49	8	33957083
Pubmed	Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.	RPL22 PRPF19 OLA1 FKBP4	1.16e-03	327	49	4	34428256
Pubmed	The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.	RPL22L1 CCL20	1.25e-03	37	49	2	8076819
Cytoband	15q25.2	GOLGA6L10 GOLGA6L9 GOLGA6L4	1.29e-05	43	48	3	15q25.2
Cytoband	Ensembl 112 genes in cytogenetic band chr15q25	GOLGA6L10 GOLGA6L9 GOLGA6L4	6.40e-04	160	48	3	chr15q25
GeneFamily	Chemokine ligands\|Endogenous ligands	CCL20 CXCL12	1.48e-03	45	23	2	483
Coexpression	ERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP	VEZT NAE1 SHPRH IFIT5 OAS3 ANKRD36 RPL22L1 GOLGA6L9 EDRF1 HERC5	3.09e-07	687	47	10	M41022
Coexpression	TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP	PDE1C IFIT5 OAS3 RTN1 HERC5	1.90e-05	183	47	5	M6670
Coexpression	GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_UP	JAK2 OAS3 PDCL2 FKBP4 HERC5	2.39e-05	192	47	5	M5665
Coexpression	LTE2_UP.V1_DN	JAK2 AGTR1 IFIT5 OAS3 HERC5	2.58e-05	195	47	5	M2721
Coexpression	GSE14000_UNSTIM_VS_16H_LPS_DC_TRANSLATED_RNA_DN	IFIT5 OAS3 CCL20 HERC5 CYTIP	2.71e-05	197	47	5	M3344
Coexpression	GSE13485_DAY3_VS_DAY7_YF17D_VACCINE_PBMC_DN	JAK2 IFIT5 OAS3 CCL20 HERC5	2.77e-05	198	47	5	M3302
Coexpression	GSE3982_CTRL_VS_PMA_STIM_EOSINOPHIL_DN	DROSHA NAE1 RTN1 FKBP4 CYTIP	2.91e-05	200	47	5	M5364
Coexpression	FARMER_BREAST_CANCER_CLUSTER_1	OAS3 HERC5 CYTIP	8.83e-05	48	47	3	M15015
Coexpression	GSE27859_MACROPHAGE_VS_CD11C_INT_F480_INT_DC_UP	JAK2 CAMTA2 CLINT1 ANKRD27	2.51e-04	171	47	4	M8594
Coexpression	ERWIN_COHEN_BLOOD_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_7DY_UP	IFIT5 OAS3 HERC5	2.95e-04	72	47	3	M41023
Coexpression	GSE21546_UNSTIM_VS_ANTI_CD3_STIM_ELK1_KO_DP_THYMOCYTES_UP	IFIT5 OAS3 RTN1 CYTIP	3.74e-04	190	47	4	M7537
Coexpression	BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE	IFIT5 OAS3 HERC5	3.74e-04	78	47	3	M2532
Coexpression	GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_18H_DN	IFIT5 OAS3 MRPL40 HERC5	3.89e-04	192	47	4	M4296
Coexpression	GSE1925_3H_VS_24H_IFNG_STIM_MACROPHAGE_DN	MYLK3 IQCH OAS3 FKBP4	4.29e-04	197	47	4	M6291
Coexpression	GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_DN	DROSHA IFIT5 OAS3 HERC5	4.29e-04	197	47	4	M9580
Coexpression	GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP	OAS3 MRPL40 RTN1 HERC5	4.29e-04	197	47	4	M9797
Coexpression	GSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN	JAK2 IFIT5 OAS3 HERC5	4.37e-04	198	47	4	M8969
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN	IFIT5 OAS3 CCL20 HERC5	4.37e-04	198	47	4	M4272
Coexpression	GSE3982_EOSINOPHIL_VS_NEUTROPHIL_UP	DROSHA PRPF19 MRPL40 FAN1	4.45e-04	199	47	4	M5404
Coexpression	GSE3039_CD4_TCELL_VS_NKT_CELL_UP	SHPRH CAMTA2 EDRF1 CYTIP	4.54e-04	200	47	4	M6426
Coexpression	GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_DN	PRPF19 MRPL40 ATAD2 FKBP4	4.54e-04	200	47	4	M7599
Coexpression	GSE21360_NAIVE_VS_QUATERNARY_MEMORY_CD8_TCELL_UP	DROSHA IFIT5 OAS3 HERC5	4.54e-04	200	47	4	M7613
Coexpression	GSE13485_CTRL_VS_DAY7_YF17D_VACCINE_PBMC_DN	JAK2 IFIT5 OAS3 HERC5	4.54e-04	200	47	4	M3288
Coexpression	GSE37533_PPARG1_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN	JAK2 IFIT5 OAS3 HERC5	4.54e-04	200	47	4	M8967
Coexpression	GSE22886_CTRL_VS_LPS_24H_DC_DN	IFIT5 OAS3 CCL20 HERC5	4.54e-04	200	47	4	M4520
Coexpression	GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_UP	PRPF19 OAS3 MRPL40 OLA1	4.54e-04	200	47	4	M7606
Coexpression	GSE29949_CD8_NEG_DC_SPLEEN_VS_DC_BRAIN_DN	JAK2 IFIT5 PRPF19 CCL20	4.54e-04	200	47	4	M8403
Coexpression	GSE42021_CD24INT_VS_CD24LOW_TCONV_THYMUS_DN	IFIT5 OAS3 BTN2A1 HERC5	4.54e-04	200	47	4	M9597
Coexpression	GSE1432_CTRL_VS_IFNG_24H_MICROGLIA_DN	JAK2 IFIT5 OAS3 HERC5	4.54e-04	200	47	4	M3408
Coexpression	HALLMARK_ESTROGEN_RESPONSE_EARLY	JAK2 ABCA3 FKBP4 CXCL12	4.54e-04	200	47	4	M5906
Coexpression	HALLMARK_ESTROGEN_RESPONSE_LATE	JAK2 ABCA3 FKBP4 CXCL12	4.54e-04	200	47	4	M5907
Coexpression	GSE42021_TREG_VS_TCONV_PLN_UP	JAK2 IFIT5 OAS3 HERC5	4.54e-04	200	47	4	M9572
Coexpression	GSE16451_CTRL_VS_WEST_EQUINE_ENC_VIRUS_MATURE_NEURON_CELL_LINE_UP	JAK2 NBAS ABCA3 CCL20	4.54e-04	200	47	4	M7424
Coexpression	BLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_UP	JAK2 IFIT5 OAS3 HERC5	4.89e-04	204	47	4	M34006
Coexpression	NAKAYA_PBMC_FLUAD_IMUVAC_MALE_AGE_14_27YO_CORRELATED_WITH_HAI_RESPONSE_MF59_ADJUVANTED_AND_NON_1DY_GENES_IN_BTM_M75_POSITIVE	OAS3 HERC5	5.28e-04	19	47	2	M41012
Coexpression	LI_ESTROGENE_EARLY_E2_RESPONSE_UP	JAK2 FKBP4 CXCL12	5.33e-04	88	47	3	M48213
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE1C IFIT5 OAS3 HERC5	1.67e-06	78	49	4	d5e2e2e04e380b265b2530e93cba6f98ad329e4f
Disease	Influenza	IFIT5 OAS3 HERC5	6.50e-05	52	44	3	C0021400
Disease	IgA glomerulonephritis (is_marker_for)	AGTR1 CCL20	4.06e-04	20	44	2	DOID:2986 (is_marker_for)
Disease	response to peginterferon alfa-2a	NBAS IQCH	6.38e-04	25	44	2	EFO_0010103
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	AGTR1 CXCL12	9.21e-04	30	44	2	DOID:4780 (biomarker_via_orthology)
Disease	Ulcerative Colitis	JAK2 CCL20	4.01e-03	63	44	2	C0009324
Disease	transient cerebral ischemia (implicated_via_orthology)	JAK2 CCL20	4.13e-03	64	44	2	DOID:224 (implicated_via_orthology)
Disease	Neoplasm Metastasis	AGTR1 CCL20 CXCL12	4.16e-03	217	44	3	C0027627
Disease	myocardial infarction (implicated_via_orthology)	JAK2 CXCL12	4.39e-03	66	44	2	DOID:5844 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLQYLQKVVLKDLWK	BRDT	31	Q58F21
TLIWKALKKAYEIQK	AGTR1	216	P30556
KQLTWIALKFALYKK	CAMTA2	1086	O94983
LWKNYTLQKRKVLVT	ABCA3	11	Q99758
LALWKRNDLKKKALL	ABLIM2	596	Q6H8Q1
KIKNTFCLWKRLIKL	ANKRD36	1371	A6QL64
QLKRKIRKKSNWYLG	ATAD2	1161	Q6PL18
IRKKSNWYLGTIKKR	ATAD2	1166	Q6PL18
WQELYQLQAKQKKLK	CCDC197	26	Q8NCU1
VKIWFQNKRSKYKKL	DLX4	161	Q92988
WLLYCHKTRLKKILK	IQCH	406	Q86VS3
TYLKKNKNCINILWK	JAK2	636	O60674
LSEKDYIRKKNKWLI	OLA1	231	Q9NTK5
KKLSKKWINYLKLKD	C8orf48	81	Q96LL4
TVKIRKKWNSKLYDL	ANKRD27	916	Q96NW4
DNKKNWRRVYKSLLL	CLINT1	71	Q14677
YQRLIDQKWQRKKKS	EDRF1	181	Q3B7T1
TYRKKRLQEWKALKK	PDCL2	71	Q8N4E4
SQLLLQKYIAQRKWK	MYLK3	786	Q32MK0
KIWLRLRGLRKYKKT	PDE1C	26	Q14123
KLAAAKKKLKAYWQR	GOLGA6L3	21	A6NEY3
KLAAAKKKLKAYWQR	GOLGA6L4	21	A6NEF3
KLAAAKKKLKAYWQR	GOLGA6L9	21	A6NEM1
KLAAAKKKLKAYWQR	GOLGA6L10	21	A6NI86
KLAAAKKKLKAYWQR	GOLGA6L19	21	H0YKK7
KGQKLDKYKATWLRL	MPND	151	Q8N594
IQNYLSKIKKRSWVL	NBAS	571	A2RRP1
ILLWIKKENSYVNLK	HERC5	371	Q9UII4
VKLWDLRKLKNFKTL	PRPF19	416	Q9UMS4
RKNSWNKALELLKKA	IFIT5	261	Q13325
LKHELQLKKWKNRLI	FBXL13	111	Q8NEE6
IYWINKLQKEKKILS	BTN2A1	266	Q7KYR7
LKQTLKQKWVEYRSL	CYTIP	181	O60759
LWKKYQPYKVIKQKL	HEPACAM2	371	A8MVW5
YKQALLQYKKIVSWL	FKBP4	286	Q02790
KLKSLIRLVKHWYQQ	OAS3	941	Q9Y6K5
KLYVRLFQRKLSWIK	FAN1	416	Q9Y2M0
KQKAIDLLYWRDIKQ	RTN1	586	Q16799
LLLKKWSLYKQQERK	MRPL40	116	Q9NQ50
QKLWKSYVKLRHLLA	DROSHA	791	Q9NRR4
WLQKKRRIKLYQKPE	SHPRH	191	Q149N8
WVKYIVRLLSKKVKN	CCL20	81	P78556
ANYVVKDRWKVLKKI	TTBK1	26	Q5TCY1
LQKQYKVKLDLWLKT	UBTFL1	276	P0CB47
TKKYLKKNNLRDWLR	RPL22L1	81	Q6P5R6
YRKLKALWSKEQKAR	SPATA46	216	Q5T0L3
LTKKYLKKNNLRDWL	RPL22	86	P35268
RLWRTAKLQVTLKKY	VEZT	186	Q9HBM0
LKWIQEYLEKALNKR	CXCL12	76	P48061
KLLKEQKYDRQLRLW	NAE1	6	Q13564
QKLLKKIGISWNKKY	USP40	366	Q9NVE5