Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcilium

DNAH3 ALMS1 DHRS3 PTPN23 STRC SPAG8 DDX6 STRCP1 GRK1

2.87e-04898519GO:0005929
GeneOntologyCellularComponent9+2 non-motile cilium

STRC STRCP1

5.21e-0414512GO:0097732
GeneOntologyCellularComponentkinocilium

STRC STRCP1

5.21e-0414512GO:0060091
DomainHnRNP_R/Q_splicing_fac

SYNCRIP HNRNPR

6.99e-055502IPR006535
DomainFG_GAP

GPLD1 CRTAC1

1.57e-0322502PS51470
DomainFG-GAP

GPLD1 CRTAC1

1.87e-0324502PF01839
DomainFG-GAP

GPLD1 CRTAC1

1.87e-0324502IPR013517
DomainQ_MOTIF

DDX50 DDX6

4.41e-0337502PS51195
DomainRNA_helicase_DEAD_Q_motif

DDX50 DDX6

4.41e-0337502IPR014014
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

2.11e-06251234910522
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

2.11e-06251211687802
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

6.32e-06351230801007
Pubmed

Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing.

POLR2A SYNCRIP

6.32e-06351212376575
Pubmed

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.

SYNCRIP HNRNPR

6.32e-06351230755280
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRC STRCP1

1.26e-05451218849963
Pubmed

Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?

SYNCRIP HNRNPR

1.26e-05451211773003
Pubmed

SMN interacts with a novel family of hnRNP and spliceosomal proteins.

SYNCRIP HNRNPR

1.26e-05451211574476
Pubmed

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.

POLR2A DYRK1A

1.26e-05451229849146
Pubmed

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

DDX50 MRPL44 DDX6 SYNCRIP HNRNPR

1.91e-0522351520020773
Pubmed

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.

GTF2H4 POLR2A

2.10e-05551216246722
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRC STRCP1

2.10e-05551224920589
Pubmed

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.

CUL2 POLR2A

4.41e-05751212604794
Pubmed

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.

TNFRSF10B OTUD7B

4.41e-05751219427028
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

CLPTM1L PDPR ALMS1 DDX50 BAZ2A POLG MRPL44 MRPL3 SYNCRIP HNRNPR

5.36e-051496511032877691
Pubmed

Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy.

SYNCRIP HNRNPR

5.87e-05851212183049
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRC STRCP1

5.87e-05851221165971
Pubmed

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

SYNCRIP HNRNPR

5.87e-05851219808671
Pubmed

The Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning.

GTF2H4 POLR2A

7.54e-05951233453189
Pubmed

TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.

GTF2H4 POLR2A

7.54e-05951218391197
Pubmed

Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.

CUL2 POLR2A

7.54e-05951228775317
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

CUL2 ALMS1 DYRK1A DDX6 SYNCRIP HNRNPR

8.35e-0549451626831064
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

LRRC8C DNAH3 FBXO10 DHRS3 SLC22A16 POLR2A HNRNPR

9.52e-0573651729676528
Pubmed

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

ALMS1 ZFYVE16 PTPN23

9.58e-056051334761192
Pubmed

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

BAZ2A HDC HNRNPR

1.11e-046351317672918
Pubmed

SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.

SYNCRIP HNRNPR

1.15e-041151210734137
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRC STRCP1

1.15e-041151231776257
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRC STRCP1

1.15e-041151231448880
Pubmed

RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway.

SYNCRIP HNRNPR

1.15e-041151237142680
Pubmed

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.

GTF2H4 POLR2A

1.38e-04125128692842
Pubmed

The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation.

SYNCRIP HNRNPR

1.38e-041251216236758
Pubmed

BRCA1 is a component of the RNA polymerase II holoenzyme.

GTF2H4 POLR2A

1.38e-04125129159119
Pubmed

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.

CUL2 POLR2A

1.63e-041351219037258
Pubmed

Cardiac deletion of Smyd2 is dispensable for mouse heart development.

POLR2A MRPL3

1.63e-041351220305823
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

DDX50 POLR2A MRPL44 MRPL3 DDX6 SYNCRIP HNRNPR

1.68e-0480751722681889
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

DDX6 SYNCRIP HNRNPR

2.25e-048051335803934
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

CUL2 GTF2H4 DDX50 ZFYVE16 PTPN23 OTUD7B

2.48e-0460451638803224
Pubmed

Near-atomic resolution visualization of human transcription promoter opening.

GTF2H4 POLR2A

2.50e-041651227193682
Pubmed

A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.

SYNCRIP HNRNPR

2.83e-041751212388589
Pubmed

Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

STRC STRCP1

2.83e-041751220856818
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

CUL2 MRPL44 DDX6 SYNCRIP HNRNPR

2.98e-0440051535013556
Pubmed

Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.

POLR2A SYNCRIP HNRNPR

2.99e-048851326318153
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

POLR2A DDX6 HNRNPR OTUD7B

3.08e-0422051424550385
Pubmed

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

POLR2A SYNCRIP HNRNPR

3.09e-048951322446626
Pubmed

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

POLR2A DDX6

3.18e-041851221030982
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

ALMS1 MRPL44 SYNCRIP HNRNPR

3.41e-0422651425900982
Pubmed

A genome-wide association study of the metabolic syndrome in Indian Asian men.

DYRK1A CRTAC1

3.55e-041951220694148
Pubmed

Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.

SCMH1 DPY19L4

3.94e-042051222028030
Pubmed

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells.

DPPA5 DDX6

3.94e-042051225416063
Pubmed

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

GTF2H4 POLR2A

4.35e-04215129852112
Pubmed

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.

GTF2H4 POLR2A

4.35e-04215129334327
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

CUL2 POLR2A SYNCRIP HNRNPR

4.56e-0424451429884807
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

GTF2H4 DDX50 POLR2A DYRK1A DDX6

4.61e-0444051534244565
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ALMS1 ZFYVE16 BAZ2A

4.87e-041045139205841
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

DDX50 BAZ2A POLR2A HNRNPR

5.07e-0425151428077445
Pubmed

The protein interaction landscape of the human CMGC kinase group.

GTF2H4 ALMS1 DDX50 DYRK1A DDX6 HNRNPR

5.23e-0469551623602568
Pubmed

Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation.

GTF2H4 POLR2A

5.23e-042351210438593
Pubmed

Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.

GTF2H4 POLR2A

5.23e-042351210866664
Pubmed

Transcriptional control: Tat cofactors and transcriptional elongation.

GTF2H4 POLR2A

5.23e-04235129651670
Pubmed

A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.

GTF2H4 POLR2A

5.23e-04235129311822
Pubmed

Tat, Tat-associated kinase, and transcription.

GTF2H4 POLR2A

5.23e-04235129570510
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CUL2 CLPTM1L DDX50 ZFYVE16 PTPN23 MRPL3 PIGO SYNCRIP

5.60e-04129751833545068
Pubmed

The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.

GTF2H4 POLR2A

5.70e-042451214569024
Pubmed

Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.

GTF2H4 POLR2A

5.70e-042451210066804
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

CLPTM1L ZFYVE16 APMAP PTPN23 DDX6 SYNCRIP

5.76e-0470851639231216
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

DDX50 MRPL44 MRPL3 DDX6 SYNCRIP HNRNPR

5.98e-0471351629802200
Pubmed

Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.

GTF2H4 POLR2A

6.19e-04255129184228
Pubmed

Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.

GTF2H4 POLR2A

6.19e-04255129790902
Pubmed

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.

GTF2H4 POLR2A

6.19e-04255128934526
Pubmed

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.

ELOVL4 GBA2

6.19e-042551219092943
Pubmed

Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.

GTF2H4 POLR2A

6.19e-04255129512541
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

DDX6 SYNCRIP HNRNPR

6.37e-0411451331553912
Pubmed

An ID2-dependent mechanism for VHL inactivation in cancer.

CUL2 DYRK1A

6.70e-042651226735018
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CUL2 ZFYVE16 POLR2A MRPL44 MRPL3 DDX6 SYNCRIP HNRNPR

6.76e-04133551829229926
Pubmed

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

DDX6 SYNCRIP

7.23e-042751230442762
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GTF2H4 DDX50 BAZ2A POLR2A PTPN23 DDX6 SYNCRIP HNRNPR

7.38e-04135351829467282
Pubmed

Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.

MRPL44 MRPL3

7.78e-042851232376682
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

CUL2 POLR2A PTPN23 MRPL3 HNRNPR

8.06e-0449851536634849
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

GTF2H4 DDX50 MRPL44 DDX6 SYNCRIP HNRNPR

8.27e-0475951635915203
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

DDX50 APMAP POLR2A MRPL44 DDX6 SYNCRIP HNRNPR

9.70e-04108251738697112
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

CLPTM1L DDX50 POLR2A DYRK1A

9.86e-0430051428561026
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CLPTM1L DDX50 APMAP POLR2A MRPL44 DDX6 SYNCRIP HNRNPR

1.03e-03142551830948266
Pubmed

The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.

GTF2H4 POLR2A

1.08e-03335129765201
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CUL2 CLPTM1L DDX50 VPS8 MRPL3 DDX6 SYNCRIP HNRNPR

1.10e-03144051830833792
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

GALNT8 POLG TNFRSF10B CHIT1

1.15e-0331351420800603
Pubmed

Molecular composition of IMP1 ribonucleoprotein granules.

SYNCRIP HNRNPR

1.29e-033651217289661
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CUL2 CLPTM1L PDPR BAZ2A MRPL44 MRPL3 TNFRSF10B SYNCRIP

1.36e-03148751833957083
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

DDX50 BAZ2A SYNCRIP HNRNPR

1.40e-0333051433301849
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

STRC STRCP1

1.43e-033851238346162
InteractionMRRF interactions

PDPR DDX50 POLG MRPL44 MRPL3 SYNCRIP HNRNPR

7.43e-06299497int:MRRF
InteractionMRPL58 interactions

PDPR DDX50 POLG MRPL44 MRPL3 SYNCRIP HNRNPR

4.82e-05400497int:MRPL58
InteractionMETTL15 interactions

PDPR MRPL44 MRPL3 SPAG8 SYNCRIP HNRNPR

5.12e-05274496int:METTL15
InteractionMETTL17 interactions

PDPR POLG MRPL44 MRPL3 DDX6 SYNCRIP HNRNPR

5.72e-05411497int:METTL17
InteractionMTRES1 interactions

PDPR POLG MRPL44 MRPL3 SYNCRIP HNRNPR

6.88e-05289496int:MTRES1
InteractionAGO1 interactions

DDX50 POLR2A DDX6 SYNCRIP OTUD7B

8.06e-05183495int:AGO1
CytobandEnsembl 112 genes in cytogenetic band chr9p13

FBXO10 SPAG8 GBA2 PIGO

4.33e-05174514chr9p13
Cytoband9p13.3

SPAG8 GBA2 PIGO

8.24e-05755139p13.3
Cytoband15q15.3

STRC STRCP1

3.57e-042551215q15.3
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

2.81e-062502DOID:0110471 (implicated_via_orthology)
Diseasebasophil measurement

SLC7A8 DYRK1A HDC

1.46e-0460503EFO_0803539
DiseaseGeneralized hypotonia

POLR2A DDX6

2.91e-0415502C1858120
Diseaseblood metabolite measurement

ALMS1 SLC22A16

4.72e-0419502EFO_0005664
DiseaseGlobal developmental delay

POLR2A DDX6 HNRNPR

1.50e-03133503C0557874

Protein segments in the cluster

PeptideGeneStartEntry
ELLMGIFEMGWEKPS

DDX6

106

P26196
WIRDPEMLDAMLKAL

BAZ2A

1441

Q9UIF9
MEAGGLPLELWRMIL

FBXO10

1

Q9UK96
KGLRMPFDEKMDPWL

ALMS1

2666

Q8TCU4
MLDFLSERPWIKRMI

APMAP

331

Q9HDC9
KLAEAMNALELGPWM

DPPA5

101

A6NC42
EVLLGMPYDLAIDMW

DYRK1A

331

Q13627
RRKAMPWALSLLLMG

CST9

6

Q5W186
RMPMIWLDLKEAGDF

PTPN23

6

Q9H3S7
FGEKLLGVMAWIMPI

SLC7A8

306

Q9UHI5
MVLLMIPWGSAAKLV

CHIT1

11

Q13231
LGMWGFHDRDLMLRK

OTUD7B

201

Q6GQQ9
EMNVMDWLAKMLGLP

HDC

116

P19113
WMKDREPFQMRLVLI

ELOVL4

66

Q9GZR5
LFEKAGPIWDLRLMM

SYNCRIP

181

O60506
WDIFLMIIAGMKLLR

PCNX2

1221

A6NKB5
EVMPLMYDLKVPRWD

PDPR

436

Q8NCN5
EKAGPIWDLRLMMDP

HNRNPR

186

O43390
MRVTPKLMALTWDGF

POLG

596

P54098
PRLMKLGEDITLWGM

FKBP6

81

O75344
MLAVPNMRFGIFLLW

GABRR1

1

P24046
TVNPMMLRLKELWFA

DNAH3

346

Q8TD57
LEFSLAWDMPRIMFG

GBA2

406

Q9HCG7
MMFWRKLPKALFIGL

GALNT8

1

Q9NY28
LMEIGELALDMWRKL

CUL2

136

Q13617
MPGKLLWGDIMELEA

DDX50

1

Q9BQ39
LWKEFFPRLMTELME

DPY19L4

541

Q7Z388
DPGMSRMLPFLLLLW

CRTAC1

6

Q9NQ79
KDLNWRQLEAGMLMP

GRK1

456

Q15835
MMFPWKQLILLSFIG

CNTN3

1

Q9P232
MVWKRLGALVMFPLQ

DHRS3

1

O75911
RVGLIALKLGMMPLW

MRPL3

96

P09001
FFLMKRKIIVLMPWL

TAS2R40

131

P59535
MWKIINPMGLLVEEL

MRPL44

231

Q9H9J2
VYWPLRGKREAMLEM

SPAG8

341

Q99932
KWLAMLIQPLFMFGV

SLC22A16

151

Q86VW1
ALWFPLLEAMMAPQK

VPS8

1141

Q8N3P4
WEPMLGLLGDMLALL

STRC

106

Q7RTU9
WPMFLLKTLNGAEMA

SCMH1

136

Q96GD3
KALKMTIFWRGLMPE

CLPTM1L

366

Q96KA5
LAKNWVMRMLFLEQP

GTF2H4

51

Q92759
VRGLPYAMMDKRLIW

TMC8

36

Q8IU68
HIKTFRMRMLWGLPL

SPATA31D1

906

Q6ZQQ2
RMRMLWGLPLKVLES

SPATA31D1

911

Q6ZQQ2
MNLLMFLSTWDGKVP

POLR2A

561

P24928
MSAFRLWPGLLIMLG

GPLD1

1

P80108
FDSWEPLMRKLGLMD

TNFRSF10B

351

O14763
VWRKMFRALMPALEE

TRIM72

276

Q6ZMU5
MLFVRWGLPLMALGT

PIGO

701

Q8TEQ8
WEPMLGLLGDMLALL

STRCP1

106

A6NGW2
LEIPWAKVFPMRLML

ZFYVE16

1181

Q7Z3T8
LSVKFDDMRELPPWM

LRRC8C

496

Q8TDW0