Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25	7.17e-09	37	143	7	GO:0004190
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	7.84e-09	11	143	5	GO:0004523
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25	8.74e-09	38	143	7	GO:0070001
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.34e-08	14	143	5	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.26e-07	21	143	5	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.36e-06	37	143	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	7.29e-06	38	143	5	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.90e-05	46	143	5	GO:0016893
GeneOntologyMolecularFunction	interleukin-15 receptor activity	IL15RA IL2RG	1.52e-04	3	143	2	GO:0042010
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	2.59e-04	79	143	5	GO:0004521
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-7 ERVK-10 TLL1 FURIN ERVK-8 ERVK-18 ERVK-19 HABP2 ERVK-25 PLG	2.75e-04	430	143	11	GO:0004175
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	TMC2 GRM7 OPRM1 CACNA1I	3.26e-04	46	143	4	GO:0005245
GeneOntologyMolecularFunction	calcium channel activity	TMC2 TRPM2 PKD1L2 GRM7 OPRM1 CACNA1I	3.35e-04	129	143	6	GO:0005262
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ANKK1 ERVK-6 MAK SPEG MAGI3 ERVK-7 ERVK-10 PSTK PIK3C2G BUB1B ERVK-8 MAP3K10 LTBP1 FGFR2 MAPK4 ERVK-11 EPHA3	3.99e-04	938	143	17	GO:0016772
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TMC2 TRPM2 PKD1L2 GRM7 OPRM1 CACNA1I	7.72e-04	151	143	6	GO:0015085
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNH7 TMC2 TRPM2 PKD1L2 SHROOM2 GRM7 TMEM38B OPRM1 CACNA1I	8.33e-04	343	143	9	GO:0005261
GeneOntologyMolecularFunction	growth factor binding	REG3G FURIN LTBP1 FGFR2 IL2RG EPHA3	9.15e-04	156	143	6	GO:0019838
GeneOntologyMolecularFunction	structural molecule activity	MYBPH ERVK-6 SPAG4 MAP4 MBP ERVK-7 ERVK-10 ENAM HMCN2 ERVK-8 ERVK-18 ERVK-19 LTBP1 ERVK-25 MUC4	1.84e-03	891	143	15	GO:0005198
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.77e-08	13	142	5	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-7 ERVK-10 HROB ERVK-8 ERVK-11	9.26e-07	48	142	6	GO:0000731
GeneOntologyBiologicalProcess	embryo development	SEMA3F SUPT20HL1 SRSF1 SPEG RNF112 AFF3 MBP GATA3 SUPT20HL2 BCL2L1 TNRC6C SOX8 MED1 CR1 YTHDC1 WDR19 FZD1 KITLG LRIG1 GLI2 FURIN COBL FGFR2 PLG PRRC2B	1.53e-05	1437	142	25	GO:0009790
GeneOntologyBiologicalProcess	in utero embryonic development	SRSF1 SPEG GATA3 BCL2L1 SOX8 MED1 CR1 YTHDC1 WDR19 GLI2 FURIN FGFR2 PLG PRRC2B	6.53e-05	596	142	14	GO:0001701
GeneOntologyBiologicalProcess	embryonic hemopoiesis	GATA3 TNRC6C MED1 KITLG	6.67e-05	32	142	4	GO:0035162
GeneOntologyBiologicalProcess	positive regulation of gluconeogenesis	FOXO1 SUPT20HL1 SUPT20HL2 OPRM1	6.67e-05	32	142	4	GO:0045722
GeneOntologyCellularComponent	photoreceptor outer segment	MAK MYRIP PEX6 TULP1 WDR19 PTPRK	1.20e-04	111	144	6	GO:0001750
GeneOntologyCellularComponent	photoreceptor cell cilium	MAK MYRIP PEX6 TULP1 WDR19 PTPRK	4.08e-04	139	144	6	GO:0097733
GeneOntologyCellularComponent	non-motile cilium	DRD1 MAK MYRIP PEX6 TULP1 WDR19 PTPRK	4.26e-04	196	144	7	GO:0097730
Domain	IGc2	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 NEO1 HMCN2 LRIG1 FGFR2	7.17e-06	235	133	10	SM00408
Domain	Ig_sub2	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 NEO1 HMCN2 LRIG1 FGFR2	7.17e-06	235	133	10	IPR003598
Domain	Ig_I-set	MYBPH CHL1 CNTN4 SPEG NEO1 HMCN2 LRIG1 PTPRK FGFR2	8.88e-06	190	133	9	IPR013098
Domain	I-set	MYBPH CHL1 CNTN4 SPEG NEO1 HMCN2 LRIG1 PTPRK FGFR2	8.88e-06	190	133	9	PF07679
Domain	fn3	MYBPH CHL1 CNTN4 SPEG NEO1 PTPRK IL2RG EPHA3	2.11e-05	162	133	8	PF00041
Domain	FN3	MYBPH CHL1 CNTN4 SPEG NEO1 PTPRK IL2RG EPHA3	5.44e-05	185	133	8	SM00060
Domain	PDZ	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	6.78e-05	141	133	7	PF00595
Domain	FN3	MYBPH CHL1 CNTN4 SPEG NEO1 PTPRK IL2RG EPHA3	9.07e-05	199	133	8	PS50853
Domain	PDZ	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	9.21e-05	148	133	7	SM00228
Domain	-	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	1.00e-04	150	133	7	2.30.42.10
Domain	PDZ	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	1.04e-04	151	133	7	PS50106
Domain	PDZ	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	1.09e-04	152	133	7	IPR001478
Domain	FN3_dom	MYBPH CHL1 CNTN4 SPEG NEO1 PTPRK IL2RG EPHA3	1.27e-04	209	133	8	IPR003961
Domain	Ago_hook	TNRC6B TNRC6C	1.50e-04	3	133	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	1.50e-04	3	133	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	1.50e-04	3	133	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	1.50e-04	3	133	2	PF16608
Domain	IG_LIKE	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 SLAMF1 NEO1 HMCN2 LRIG1 PTPRK FGFR2	2.06e-04	491	133	12	PS50835
Domain	IG	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 NEO1 HMCN2 LRIG1 PTPRK FGFR2	2.15e-04	421	133	11	SM00409
Domain	Ig_sub	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 NEO1 HMCN2 LRIG1 PTPRK FGFR2	2.15e-04	421	133	11	IPR003599
Domain	Ig-like_dom	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 SLAMF1 NEO1 HMCN2 LRIG1 PTPRK FGFR2	2.56e-04	503	133	12	IPR007110
Domain	Defensin_propep	DEFA1 DEFA3	4.96e-04	5	133	2	PF00879
Domain	NUT	NUTM2A NUTM2B	4.96e-04	5	133	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	4.96e-04	5	133	2	IPR024309
Domain	Alpha-defensin	DEFA1 DEFA3	4.96e-04	5	133	2	IPR006081
Domain	NUT	NUTM2A NUTM2B	4.96e-04	5	133	2	PF12881
Domain	Alpha-defensin_pro	DEFA1 DEFA3	4.96e-04	5	133	2	IPR016327
Domain	DEFENSIN	DEFA1 DEFA3	4.96e-04	5	133	2	PS00269
Domain	Defensin_propep	DEFA1 DEFA3	4.96e-04	5	133	2	IPR002366
Domain	Defensin_1	DEFA1 DEFA3	4.96e-04	5	133	2	PF00323
Domain	Galactose-bd-like	SPAG4 DCBLD1 PTPRK FURIN EPHA3	5.61e-04	94	133	5	IPR008979
Domain	Defensin_beta/alpha	DEFA1 DEFA3	1.37e-03	8	133	2	IPR006080
Domain	-	FSTL3 LTBP1	1.37e-03	8	133	2	3.90.290.10
Domain	DEFSN	DEFA1 DEFA3	1.37e-03	8	133	2	SM00048
Domain	Ig-like_fold	MYBPH CHL1 SEMA3F CNTN4 SPEG SIGLEC5 NEO1 HMCN2 LRIG1 PTPRK FGFR2 IL2RG EPHA3	1.60e-03	706	133	13	IPR013783
Domain	TB_dom	FSTL3 LTBP1	1.75e-03	9	133	2	IPR017878
Domain	TB	FSTL3 LTBP1	1.75e-03	9	133	2	PS51364
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERV3-1 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-11	3.76e-10	94	153	9	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-18 ERVK-19	1.79e-09	5	153	4	12629516
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	8.35e-08	3	153	3	10516026
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 MAP4 ERV3-1 RBBP4 SIPA1L3 PPP1R9A B3GALNT2 TRPM2 AFF3 MBP MYRIP TNRC6B MAGI3 ANKMY1 TNRC6C SHROOM2 USF3 GLI2 FUBP1 TLL1 NAXD ANKRD17 COBL	1.64e-07	1489	153	23	28611215
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERV3-1 ERVK-8 ERVK-19	1.73e-07	12	153	4	14557543
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	3.33e-07	4	153	3	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10 ERVK-19	3.33e-07	4	153	3	7983737
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-10 ERVK-18 ERVK-25 ERVK-11	1.05e-06	18	153	4	18664271
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA3F RAPGEF6 SPEG SIPA1L3 UBR4 RTTN PEX6 TNRC6C GADD45A GGA3 NOD2 FZD1 FURIN NINL COBL FGFR2 PRRC2B	8.10e-06	1105	153	17	35748872
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERV3-1 ERVK-19	9.79e-06	10	153	3	12970426
Pubmed	Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro.	DEFA1 DEFA3	1.92e-05	2	153	2	12871849
Pubmed	Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.	ANKK1 DRD1	1.92e-05	2	153	2	29909784
Pubmed	Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas.	DEFA1 DEFA3	1.92e-05	2	153	2	18957723
Pubmed	Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling.	SRSF1 OPRM1	1.92e-05	2	153	2	26553431
Pubmed	Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.	SLAMF1 FUBP1	1.92e-05	2	153	2	26095368
Pubmed	Salivary levels of HNP 1-3 are related to oral ulcer activity in Behçet's disease.	DEFA1 DEFA3	1.92e-05	2	153	2	22861387
Pubmed	Defensins: antimicrobial and cytotoxic peptides of mammalian cells.	DEFA1 DEFA3	1.92e-05	2	153	2	8476558
Pubmed	Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series.	DEFA1 DEFA3	1.92e-05	2	153	2	8080882
Pubmed	Microarray based analysis of an inherited terminal 3p26.3 deletion, containing only the CHL1 gene, from a normal father to his two affected children.	CHL1 CNTN4	1.92e-05	2	153	2	21457564
Pubmed	SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.	SRSF1 SRSF9	1.92e-05	2	153	2	23592547
Pubmed	Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.	DEFA1 DEFA3	1.92e-05	2	153	2	19864642
Pubmed	Multidrug-resistant tuberculosis is associated with low plasma concentrations of human neutrophil peptides 1-3.	DEFA1 DEFA3	1.92e-05	2	153	2	21333105
Pubmed	Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome.	DEFA1 DEFA3	1.92e-05	2	153	2	22737966
Pubmed	Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.	DEFA1 DEFA3	1.92e-05	2	153	2	18757648
Pubmed	alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1-seropositive and -seronegative individuals.	DEFA1 DEFA3	1.92e-05	2	153	2	16837860
Pubmed	Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis.	DEFA1 DEFA3	1.92e-05	2	153	2	15208269
Pubmed	Plasma human neutrophil proteins-1, -2, and -3 levels in patients with bladder cancer.	DEFA1 DEFA3	1.92e-05	2	153	2	23011762
Pubmed	Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions.	DEFA1 DEFA3	1.92e-05	2	153	2	20880148
Pubmed	Developmental expression of HERV-R (ERV3) and HERV-K in human tissue.	ERVK-6 ERV3-1	1.92e-05	2	153	2	12083821
Pubmed	Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.	DEFA1 DEFA3	1.92e-05	2	153	2	20195543
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	1.92e-05	2	153	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	1.92e-05	2	153	2	9460924
Pubmed	The putative role of human peritoneal adipocytes in the fight against bacteria: synthesis of the antimicrobial active peptide DEFA1-3.	DEFA1 DEFA3	1.92e-05	2	153	2	20424487
Pubmed	Participation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-xL expression.	GATA3 BCL2L1	1.92e-05	2	153	2	29170477
Pubmed	Detection of colorectal disease by stool defensin assay: an exploratory study.	DEFA1 DEFA3	1.92e-05	2	153	2	17531545
Pubmed	Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients.	DEFA1 DEFA3	1.92e-05	2	153	2	29950924
Pubmed	Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers.	DEFA1 DEFA3	1.92e-05	2	153	2	18472248
Pubmed	Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.	DEFA1 DEFA3	1.92e-05	2	153	2	2006422
Pubmed	Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x.	BCL2L1 SRSF9	1.92e-05	2	153	2	18534987
Pubmed	The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.	DEFA1 DEFA3	1.92e-05	2	153	2	18474654
Pubmed	Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.	UBE2C MED1	1.92e-05	2	153	2	21556051
Pubmed	Terminal 3p deletions in two families--correlation between molecular karyotype and phenotype.	CHL1 CNTN4	1.92e-05	2	153	2	20101686
Pubmed	Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy.	DEFA1 DEFA3	1.92e-05	2	153	2	18003664
Pubmed	Human neutrophil peptides 1-3 as gastric cancer tissue markers measured by MALDI-imaging mass spectrometry: implications for infiltrated neutrophils as a tumor target.	DEFA1 DEFA3	1.92e-05	2	153	2	22297599
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	1.92e-05	2	153	2	11672541
Pubmed	Upregulated expression of human alpha-defensins 1, 2 and 3 in hypercholesteremia and its relationship with serum lipid levels.	DEFA1 DEFA3	1.92e-05	2	153	2	25300997
Pubmed	Differentiation stage-specific expression of a gene during granulopoiesis.	DEFA1 DEFA3	5.75e-05	3	153	2	2918759
Pubmed	Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes.	DEFA1 DEFA3	5.75e-05	3	153	2	25083086
Pubmed	Isolation and characterization of human defensin cDNA clones.	DEFA1 DEFA3	5.75e-05	3	153	2	3174637
Pubmed	Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.	KITLG IL2RG	5.75e-05	3	153	2	22279057
Pubmed	Posttranslational processing of defensins in immature human myeloid cells.	DEFA1 DEFA3	5.75e-05	3	153	2	1339298
Pubmed	L1 and CHL1 Cooperate in Thalamocortical Axon Targeting.	CHL1 EPHA3	5.75e-05	3	153	2	20576928
Pubmed	Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer.	CHL1 CNTN4	5.75e-05	3	153	2	19509545
Pubmed	The structure of neutrophil defensin genes.	DEFA1 DEFA3	5.75e-05	3	153	2	8477861
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-11	5.75e-05	3	153	2	9971820
Pubmed	Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population.	DEFA1 DEFA3	5.75e-05	3	153	2	20502117
Pubmed	Mediator and post-recruitment regulation of RNA polymerase II.	MED1 MED17	5.75e-05	3	153	2	21326907
Pubmed	Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion.	SRSF1 BCL2L1	5.75e-05	3	153	2	37864462
Pubmed	Rapid endocytosis of interleukin-15 by cerebral endothelia.	IL15RA IL2RG	5.75e-05	3	153	2	21155807
Pubmed	Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.	DEFA1 DEFA3	5.75e-05	3	153	2	23050799
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6B TNRC6C	5.75e-05	3	153	2	31670606
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	5.75e-05	3	153	2	26542179
Pubmed	The mouse Fubp gene maps near the distal end of chromosome 3.	GADD45A FUBP1	5.75e-05	3	153	2	10087207
Pubmed	Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.	DEFA1 DEFA3	5.75e-05	3	153	2	2917986
Pubmed	A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.	NOD2 ANKRD17	5.75e-05	3	153	2	23711367
Pubmed	Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.	SIGLEC5 PLG	5.75e-05	3	153	2	36129033
Pubmed	Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells.	DEFA1 DEFA3	5.75e-05	3	153	2	10914484
Pubmed	Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors.	IL15RA IL2RG	5.75e-05	3	153	2	17363735
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	5.75e-05	3	153	2	22456610
Pubmed	FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells.	FGFR2 IL2RG	5.75e-05	3	153	2	23300950
Pubmed	Differential mechanisms of opioidergic and dopaminergic systems of the ventral hippocampus (CA₃) in anxiolytic-like behaviors induced by cholestasis in mice.	DRD1 OPRM1	5.75e-05	3	153	2	23876451
Pubmed	Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.	DEFA1 DEFA3	5.75e-05	3	153	2	15620707
Pubmed	Human alpha-defensins inhibit Clostridium difficile toxin B.	DEFA1 DEFA3	5.75e-05	3	153	2	18435932
Pubmed	The structure of neutrophil defensin genes.	DEFA1 DEFA3	5.75e-05	3	153	2	8325384
Pubmed	MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.	GLI2 MAP3K10	5.75e-05	3	153	2	23178452
Pubmed	Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.	DEFA1 DEFA3	5.75e-05	3	153	2	8530462
Pubmed	Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise.	DEFA1 DEFA3	5.75e-05	3	153	2	19263072
Pubmed	Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis.	DEFA1 DEFA3	5.75e-05	3	153	2	12913926
Pubmed	Defensins. Natural peptide antibiotics of human neutrophils.	DEFA1 DEFA3	5.75e-05	3	153	2	2997278
Pubmed	Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8.	DEFA1 DEFA3	5.75e-05	3	153	2	21831449
Pubmed	The evaluation of the FOXO1, KLF9 and YT521 genes expression in human endometrial cancer.	FOXO1 YTHDC1	5.75e-05	3	153	2	23865345
Pubmed	Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.	MBP PLG	5.75e-05	3	153	2	28648598
Pubmed	Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.	DRD1 OPRM1	5.75e-05	3	153	2	32941853
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6B TNRC6C	5.75e-05	3	153	2	34108231
Pubmed	Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen.	DEFA1 DEFA3	5.75e-05	3	153	2	21861873
Pubmed	PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.	DEFA1 DEFA3	5.75e-05	3	153	2	28420383
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	5.75e-05	3	153	2	24220028
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6B TNRC6C	5.75e-05	3	153	2	16880270
Pubmed	Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.	DEFA1 DEFA3	5.75e-05	3	153	2	16700921
Pubmed	Primary structures of three human neutrophil defensins.	DEFA1 DEFA3	5.75e-05	3	153	2	4056036
Pubmed	Evaluation of gingival crevicular fluid adrenomedullin and human neutrophil peptide 1-3 levels of patients with different periodontal diseases.	DEFA1 DEFA3	5.75e-05	3	153	2	20151808
Pubmed	The protein interaction landscape of the human CMGC kinase group.	MAK SRSF1 RBBP4 SIPA1L3 AFF3 MED1 EPB41L4A YTHDC1 MAPK4 MED17 SRSF9 EPHA3	6.28e-05	695	153	12	23602568
Pubmed	Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.	GATA3 MED1 TGS1	7.68e-05	19	153	3	22982455
Pubmed	Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.	SLAMF1 FYB1	1.15e-04	4	153	2	12458214
Pubmed	Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.	DEFA1 DEFA3	1.15e-04	4	153	2	11960772
Pubmed	A genome-wide association study for age-related hearing impairment in the Saami.	GRM7 PTPRK	1.15e-04	4	153	2	20068591
Pubmed	Inhibitory effect of wild-type p53 gene on excessive replication of centrosomes in leukemia cell line K562.	GADD45A BUB1B	1.15e-04	4	153	2	19550118
Pubmed	Mammalian tolloid proteinases: role in growth factor signalling.	TLL1 LTBP1	1.15e-04	4	153	2	27391803
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6B TNRC6C	1.15e-04	4	153	2	21063388
Pubmed	Gata3 drives development of RORγt+ group 3 innate lymphoid cells.	GATA3 IL2RG	1.15e-04	4	153	2	24419270
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYBPH CHL1 CNTN4 SPEG NEO1 HMCN2 LRIG1 FGFR2	1.64e-06	161	92	8	593
GeneFamily	PDZ domain containing	RAPGEF6 SIPA1L3 PPP1R9A MAGI3 SHROOM2 PDLIM4 FRMPD3	1.25e-05	152	92	7	1220
GeneFamily	Fibronectin type III domain containing	MYBPH CHL1 CNTN4 NEO1 PTPRK IL2RG EPHA3	1.74e-05	160	92	7	555
GeneFamily	Immunoglobulin like domain containing	CHL1 SEMA3F CNTN4 SLAMF1 NEO1 HMCN2 PTPRK	5.77e-05	193	92	7	594
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF1 SRSF9	1.64e-03	12	92	2	737
GeneFamily	Defensins, alpha	DEFA1 DEFA3	1.64e-03	12	92	2	502
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R9A BCL2L1 GRM7 SPZ1 PPP1R37	2.32e-03	181	92	5	694
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	CHL1 CNTN4 RAPGEF6 RUNDC3B SPEG RNF112 PPP1R9A AFF3 NUTM2A GATA3 MAGI3 TNRC6C SHROOM2 GRM7 OPRM1 GSE1 PTPRK TLL1 NINL CACNA1I FRMPD3 GPR176 PRRC2B EPHA3	8.39e-09	1106	144	24	M39071
Coexpression	DURAND_STROMA_S_UP	PRUNE2 SEMA3F ARHGEF28 SPEG GATA3 PDLIM4 FZD1 KITLG FGFR2 FYB1 MN1	8.93e-07	300	144	11	M2581
Coexpression	DURAND_STROMA_S_UP	PRUNE2 SEMA3F ARHGEF28 SPEG GATA3 PDLIM4 FZD1 KITLG FGFR2 FYB1 MN1	1.02e-06	304	144	11	MM1083
Coexpression	DELACROIX_RAR_TARGETS_DN	UBE2C KITLG FUBP1 FGFR2	1.19e-05	26	144	4	M2465
Coexpression	DELACROIX_RAR_TARGETS_DN	UBE2C KITLG FUBP1 FGFR2	1.19e-05	26	144	4	MM950
Coexpression	CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN	CHL1 CNTN4 AHI1-DT RUNDC3B GPRC5C FZD1 KITLG PTPRK OSBPL10 DNAI4 COBL	1.63e-05	407	144	11	M2214
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	PRUNE2 CNTN4 AHI1-DT SIPA1L3 MYRIP TNRC6B TNRC6C YTHDC1 GADD45A WDR19 PLG	2.04e-05	417	144	11	M39224
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	CHL1 CNTN4 SRSF1 MAP4 RBBP4 SIPA1L3 PPP1R9A GATA3 MYRIP TNRC6B MED1 GRM7 PTPRK TLL1 MAP3K10 LTBP1 NAIF1 EPHA3	2.88e-06	818	131	18	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 ARHGEF28 SIPA1L3 PPP1R9A EPB41L4A PTPRK NINL OSBPL10 COBL	8.76e-10	194	145	10	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 SIPA1L3 PPP1R9A SLC3A1 PTPRK NINL OSBPL10 FGFR2	1.09e-08	186	145	9	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 EPB41L4A LRIG1 PTPRK TLL1 MUC4 CA3	1.50e-08	193	145	9	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	CHL1 CNTN4 PPP1R9A MAGI3 PTPRK FGFR2 MUC4 CA3	1.46e-07	181	145	8	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	PPP1R9A AFF3 MAGI3 KITLG LRIG1 PTPRK MUC4 CA3	1.73e-07	185	145	8	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A AFF3 MAGI3 LRIG1 PTPRK COBL FGFR2	2.21e-07	191	145	8	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A AFF3 MAGI3 LRIG1 PTPRK COBL FGFR2	2.30e-07	192	145	8	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AHI1-DT ARHGEF28 SIPA1L3 PPP1R9A SLC3A1 NINL COBL FGFR2	2.69e-07	196	145	8	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	Control\|World / group, cell type (main and fine annotations)	CNTN4 ARHGEF28 PPP1R9A AFF3 MAGI3 PTPRK COBL	1.34e-06	168	145	7	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UBE2C TRPM2 NDST2 SIGLEC5 CR1 NOD2 BUB1B	1.56e-06	172	145	7	ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRUNE2 KCNH7 DCBLD1 GRM7 OPRM1 TLL1 EPHA3	1.63e-06	173	145	7	5aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	PRUNE2 CNTN4 ARHGEF28 SPEG B3GALNT2 HMCN2 GPR176	2.36e-06	183	145	7	818fd886e0188091310825f9145fa53328f2c979
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A AFF3 MAGI3 LRIG1 PTPRK CA3	2.54e-06	185	145	7	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	CNTN4 PPP1R9A MAGI3 LRIG1 PTPRK FGFR2 MUC4	2.54e-06	185	145	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Activated_CD4_T\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAPGEF6 GATA3 TNRC6C SLAMF1 NUTM2B CACNA1I FYB1	2.73e-06	187	145	7	6bdc55213e41346c5914a290b16172cd412ac71d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3F GATA3 GPRC5C KITLG PIK3C2G LTBP1 PLA2G4F	2.73e-06	187	145	7	b7689e7f6511920cd2beff27389555fddf685f61
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 FSTL3 PPP1R9A SLC3A1 PTPRK OSBPL10	2.92e-06	189	145	7	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	PPP1R9A AFF3 CHI3L2 PTPRK COBL PLA2G4F FGFR2	3.03e-06	190	145	7	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	T_cells-Effector_memory_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	FOXO1 GATA3 MAGI3 SLAMF1 LRIG1 CACNA1I FYB1	3.03e-06	190	145	7	13dc3a0aaa554f63eabac37726bd1f11b66fb3dd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 SIPA1L3 SLC3A1 NINL OSBPL10 COBL	3.13e-06	191	145	7	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 SIPA1L3 SLC3A1 NINL OSBPL10 COBL	3.13e-06	191	145	7	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CNTN4 FSTL3 EPB41L4A PTPRK TLL1 OSBPL10	3.13e-06	191	145	7	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 AHI1-DT ARHGEF28 SIPA1L3 PPP1R9A NINL COBL	3.36e-06	193	145	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FOXO1 RAPGEF6 GATA3 TNRC6B SLAMF1 OPRM1 FYB1	3.36e-06	193	145	7	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Tfh\|lymph-node_spleen / Manually curated celltypes from each tissue	FOXO1 RAPGEF6 GATA3 TNRC6C CACNA1I FYB1 HERC5	3.36e-06	193	145	7	dea7d0b2eadff01e0e169c6916dea04253521d48
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AHI1-DT ARHGEF28 PPP1R9A SLC3A1 NINL COBL FGFR2	3.47e-06	194	145	7	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 SEMA3F PPP1R9A MAGI3 EPB41L4A FGFR2 MUC4	3.59e-06	195	145	7	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	PSB-critical-LOC-Lymphoid\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	UBE2C GATA3 SLAMF1 BUB1B CLSPN FYB1 IL2RG	3.72e-06	196	145	7	7b5c2a4cdea9a944f83bfc2c493d3076c3daaeaa
ToppCell	Sigmoid-B_cell-Follicular_B_cell\|Sigmoid / Region, Cell class and subclass	CHL1 SWAP70 SIPA1L3 AFF3 CHI3L2 CR1 PTPRK	3.97e-06	198	145	7	c3507fb508ace85a31dcff323f9e7ddb9ae6862e
ToppCell	Sigmoid-(2)_B_cell-(23)_Follicular_B_cell\|Sigmoid / shred on region, Cell_type, and subtype	CHL1 SWAP70 SIPA1L3 AFF3 CHI3L2 CR1 PTPRK	3.97e-06	198	145	7	bfb1aa1450d1afb14b875e0cf6796e1a715b4605
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 PPP1R9A BCL2L1 TLL1 FGFR2 MUC4 CA3	4.11e-06	199	145	7	527aae1d9d37a50deefc01fc0c064a53673681bd
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 SIPA1L3 PPP1R9A AFF3 TNRC6B MAGI3 OSBPL10	4.11e-06	199	145	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175\|Adult / Lineage, Cell type, age group and donor	AFF3 MYRIP DCBLD1 KITLG FAM181A MUC4	9.86e-06	150	145	6	b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF112 GATA3 SLAMF1 PIK3C2G PLA2G4F FYB1	1.64e-05	164	145	6	8f3255d7f67890389a768453492243ea982eb38a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IL15RA RUNDC3B MYRIP EPB41L4A TLL1 MN1	1.81e-05	167	145	6	d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ANKK1 RUNDC3B UBE2C NDST2 GATA3 MYRIP	1.88e-05	168	145	6	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	normal_Lung-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	PRUNE2 ARHGEF28 PPP1R9A B3GALNT2 GATA3 PDLIM4	2.07e-05	171	145	6	f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 GLI2 LTBP1 GPR176 EPHA3 SYNGR4	2.44e-05	176	145	6	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHL1 SWAP70 AFF3 USF3 PTPRK OSBPL10	2.44e-05	176	145	6	ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 GLI2 LTBP1 GPR176 EPHA3 SYNGR4	2.44e-05	176	145	6	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 CNTN4 ARHGEF28 GRM7 OSBPL10 GPR176	2.60e-05	178	145	6	544379f5a6145429762258d426b876bb36c112f5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CNTN4 AFF3 MAGI3 LRIG1 PTPRK CA3	2.60e-05	178	145	6	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 EPB41L4A PTPRK FGFR2	2.68e-05	179	145	6	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	wk_15-18-Epithelial-PNS-KCNIP4+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CHL1 KCNH7 ARHGEF28 RUNDC3B MYRIP OPRM1	2.68e-05	179	145	6	e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 DCBLD1 OPRM1 PTPRK PIK3C2G EPHA3	2.77e-05	180	145	6	5e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCell	Control-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	FOXO1 RAPGEF6 GATA3 SLAMF1 OPRM1 LRIG1	2.77e-05	180	145	6	47036eee4c128fbb443d1fc767b4de5cced93f0e
ToppCell	COVID-19-T_cells-Tregs\|COVID-19 / group, cell type (main and fine annotations)	FOXO1 GATA3 SLAMF1 OPRM1 FYB1 IL2RG	2.85e-05	181	145	6	534659cf754326c6a73c0daa30e9d610612a0292
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 MYRIP GRM7 OSBPL10 GPR176 EPHA3	2.85e-05	181	145	6	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 MYRIP GRM7 OSBPL10 GPR176 EPHA3	2.85e-05	181	145	6	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	Control-Lymphoid-T_Regulatory\|Control / Disease state, Lineage and Cell class	FOXO1 RAPGEF6 GATA3 SLAMF1 OPRM1 LRIG1	2.94e-05	182	145	6	31bb838cc2900f3c9da9f835d79d557a08abb928
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI3 EPB41L4A TLL1 FGFR2 MUC4 CA3	2.94e-05	182	145	6	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 MAK UBE2C SIGLEC5 BUB1B CLSPN	3.04e-05	183	145	6	e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 MBP SOX8 EPB41L4A PDLIM4 COBL	3.04e-05	183	145	6	8330c39184ce076e1f95fd3725b68af551d89db0
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	PRUNE2 CNTN4 ARHGEF28 B3GALNT2 HMCN2 GPR176	3.04e-05	183	145	6	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CHL1 PRUNE2 TMC2 RUNDC3B GATA3 GPR149	3.13e-05	184	145	6	571136c832cb8c08457744152231537aa8e8abd7
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	PPP1R9A AFF3 MAGI3 PTPRK PLA2G4F FGFR2	3.13e-05	184	145	6	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 CNTN4 FSTL3 LTBP1 GPR176 EPHA3	3.13e-05	184	145	6	54e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 PTPRK COBL CA3	3.13e-05	184	145	6	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 CNTN4 FSTL3 LTBP1 GPR176 EPHA3	3.13e-05	184	145	6	7b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	CNTN4 SIPA1L3 MAGI3 BCL2L1 COBL MAPK4	3.23e-05	185	145	6	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 MYRIP GRM7 OSBPL10 GPR176 EPHA3	3.23e-05	185	145	6	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FOXO1 RAPGEF6 GATA3 SLAMF1 OPRM1 IL2RG	3.23e-05	185	145	6	a86a3a1a187a4d8d7762bc6d3dcb22c982178d22
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCTD19 UBE2C HROB BUB1B CLSPN BORA	3.23e-05	185	145	6	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPEG GADD45A PDLIM4 GLI2 LTBP1 GPR176	3.23e-05	185	145	6	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 MYRIP GRM7 OSBPL10 GPR176 EPHA3	3.23e-05	185	145	6	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	PPP1R9A MAGI3 PTPRK COBL FGFR2 MUC4	3.33e-05	186	145	6	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 LRIG1 PTPRK CA3	3.43e-05	187	145	6	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 SIPA1L3 MAGI3 GPRC5C COBL FGFR2	3.43e-05	187	145	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SWAP70 SIPA1L3 AFF3 CHI3L2 PTPRK OSBPL10	3.43e-05	187	145	6	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	PRUNE2 CNTN4 ARHGEF28 B3GALNT2 HMCN2 GPR176	3.53e-05	188	145	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PPP1R9A MAGI3 PTPRK COBL FGFR2 MUC4	3.53e-05	188	145	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 FOXO1 PRUNE2 AHI1-DT OSBPL10 COBL	3.53e-05	188	145	6	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 PRUNE2 CNTN4 AHI1-DT SIPA1L3 OSBPL10	3.53e-05	188	145	6	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 CNTN4 SPEG PDLIM4 LRIG1 LTBP1	3.53e-05	188	145	6	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SIPA1L3 RTTN GATA3 KITLG OSBPL10 FGFR2	3.53e-05	188	145	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 AHI1-DT GRM7 OSBPL10 COBL FYB1	3.64e-05	189	145	6	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3F KITLG ZNF648 LTBP1 CA3 EPHA3	3.64e-05	189	145	6	222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	CNTN4 ARHGEF28 PPP1R9A LRIG1 FGFR2 MUC4	3.64e-05	189	145	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	CHL1 PPP1R9A MAGI3 PTPRK FGFR2 MUC4	3.64e-05	189	145	6	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 AHI1-DT GRM7 OSBPL10 COBL FYB1	3.64e-05	189	145	6	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	IPF-Lymphoid-T\|IPF / Disease state, Lineage and Cell class	FOXO1 RAPGEF6 GATA3 SLAMF1 OPRM1 FYB1	3.75e-05	190	145	6	d57df208aaf7a5554899bb9107c80b443fd0cf93
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 CNTN4 SPEG PDLIM4 LRIG1 LTBP1	3.75e-05	190	145	6	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SEMA3F RUNDC3B AFF3 MYRIP EPB41L4A TLL1	3.75e-05	190	145	6	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	T_cells-Effector_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FOXO1 MAGI3 SLAMF1 GADD45A LRIG1 CACNA1I	3.75e-05	190	145	6	1af91fe0ee2c924e12f4db93c793e7af475d8f80
ToppCell	IPF-Epithelial-Goblet\|IPF / Disease state, Lineage and Cell class	CHL1 PPP1R9A PTPRK COBL FGFR2 MUC4	3.75e-05	190	145	6	e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SWAP70 AFF3 CHI3L2 PTPRK OSBPL10 HERC5	3.86e-05	191	145	6	2feab42ac6d29fa4eac78f3f78a5f8aa0a559523
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	PPP1R9A MAGI3 PTPRK COBL FGFR2 MUC4	3.86e-05	191	145	6	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 AHI1-DT OSBPL10 DNAI4 COBL FGFR2	3.86e-05	191	145	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PPP1R9A AFF3 MAGI3 PTPRK PLA2G4F FGFR2	3.86e-05	191	145	6	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI3 EPB41L4A LRIG1 TLL1 MUC4 CA3	3.86e-05	191	145	6	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 AFF3 GSE1 GLI2 LTBP1 GPR176	3.86e-05	191	145	6	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	CHL1 PPP1R9A MAGI3 PTPRK FGFR2 MUC4	3.86e-05	191	145	6	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 PTPRK COBL FGFR2	3.86e-05	191	145	6	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 AFF3 GSE1 GLI2 LTBP1 GPR176	3.86e-05	191	145	6	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SPAG4 SWAP70 AFF3 ENAM OSBPL10 IL2RG	3.86e-05	191	145	6	72e3191990973440e4f91427208df360f73e4f41
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTN4 AFF3 GSE1 GLI2 LTBP1 GPR176	3.97e-05	192	145	6	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	PPP1R9A AFF3 CHI3L2 LRIG1 PTPRK PLA2G4F	3.97e-05	192	145	6	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	CNTN4 PPP1R9A MAGI3 PTPRK COBL FGFR2	3.97e-05	192	145	6	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	PPP1R9A MAGI3 PTPRK COBL FGFR2 MUC4	3.97e-05	192	145	6	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	PPP1R9A AFF3 MAGI3 PTPRK PLA2G4F FGFR2	3.97e-05	192	145	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
Drug	Nadide [53-84-9]; Up 200; 6uM; MCF7; HT_HG-U133A	PRUNE2 MAP4 OPRM1 PDLIM4 KITLG DNAI4 MUC4 MN1 GPR176	4.20e-06	197	142	9	6091_UP
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; MCF7; HT_HG-U133A	SWAP70 UBR4 TRPM2 GRM7 PPP1R37 DNAI4 CACNA1I MN1	3.16e-05	195	142	8	4402_UP
Drug	Chlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; PC3; HT_HG-U133A	SEMA3F GATA3 ANKMY1 MED1 SLC3A1 PDLIM4 FZD1 TGS1	3.28e-05	196	142	8	6692_DN
Drug	Epicatechin-(-) [154-23-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A	ARHGEF28 SWAP70 CR1 HROB DNAI4 FGFR2 MN1 CA3	3.28e-05	196	142	8	4419_UP
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	MYBPH PRUNE2 MAK TRPM2 GGA3 KITLG CACNA1I FGFR2	3.40e-05	197	142	8	3877_UP
Drug	Xamoterol hemifumarate [73210-73-8]; Down 200; 5uM; MCF7; HT_HG-U133A	ARHGEF28 SWAP70 MAP4 CR1 SLC3A1 KITLG DNAI4 HERC5	3.40e-05	197	142	8	3401_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; PC3; HT_HG-U133A	GRM7 TMEM38B SLC3A1 CACNA1I HABP2 FGFR2 FYB1 MUC4	3.40e-05	197	142	8	5765_UP
Drug	Pyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A	SRSF1 MAP4 SIPA1L3 MBP TNRC6B BCL2L1 MED1 FGFR2	3.40e-05	197	142	8	7171_DN
Drug	Ganciclovir [82410-32-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	SEMA3F FSTL3 SWAP70 MAP4 UBR4 GRM7 FYB1 PRRC2B	3.65e-05	199	142	8	5389_UP
Drug	Dipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	MAP4 PPP1R9A TRPM2 SLC3A1 WDR19 CACNA1I FGFR2 PLG	3.78e-05	200	142	8	6766_UP
Drug	alpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A	SEMA3F DRD1 TRPM2 CHI3L2 CR1 PPP1R37 CACNA1I MUC4	3.78e-05	200	142	8	5570_UP
Drug	2-methoxyethoxy)acetic acid	DEFA1 DEFA3	3.86e-05	2	142	2	CID000027642
Drug	Tribestan	ERVK-6 KITLG	3.86e-05	2	142	2	CID000134143
Drug	1,2,5,6-tetramethylnaphthalene	DEFA1 DEFA3	3.86e-05	2	142	2	CID006427081
Drug	1,4,5-trimethylnaphthalene	DEFA1 DEFA3	3.86e-05	2	142	2	CID000016478
Drug	7-benzylidenenaltrexone	DRD1 OPRM1	3.86e-05	2	142	2	ctd:C077358
Drug	p-sulfobenzyl alcohol	DEFA1 DEFA3	3.86e-05	2	142	2	CID000441138
Disease	Bicuspid aortic valve	HMCN2 MUC4	6.88e-05	3	142	2	HP_0001647
Disease	response to metformin, glucose tolerance test	ZNF648 HABP2	6.88e-05	3	142	2	EFO_0004307, GO_1901558
Disease	photoreceptor cell layer thickness measurement	TULP1 GSE1 ASB7 COBL FGFR2 MN1	8.40e-05	148	142	6	EFO_0803370
Disease	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	RAPGEF6 LINC01548 SOX8 EPB41L4A SLAMF1 PTPRK PIK3C2G PTPN20	1.98e-04	328	142	8	EFO_0008377, EFO_0008378
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	2.28e-04	5	142	2	C0206630
Disease	Alcoholic Intoxication, Chronic	ANKK1 CNTN4 DRD1 MBP GRM7 OPRM1 GLI2	3.31e-04	268	142	7	C0001973
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	3.41e-04	6	142	2	C0334488
Disease	Schizophrenia	CHL1 ANKK1 AHI1-DT DRD1 RAPGEF6 SRSF1 MBP GRM7 OPRM1 ERVK-8 FGFR2 PLG IL2RG	3.54e-04	883	142	13	C0036341
Disease	contactin-4 measurement	CHL1 CNTN4	4.75e-04	7	142	2	EFO_0020287
Disease	glypican-1 measurement	ANKMY1 HABP2	4.75e-04	7	142	2	EFO_0801649
Disease	Squamous cell carcinoma of lung	ANKK1 FGFR2 EPHA3	4.89e-04	32	142	3	C0149782
Disease	stomach cancer (is_marker_for)	SRSF1 BCL2L1 GSE1 FUBP1 FGFR2	6.35e-04	142	142	5	DOID:10534 (is_marker_for)
Disease	Hodgkins lymphoma	ARHGEF28 GATA3 PTPRK CACNA1I	6.72e-04	82	142	4	EFO_0000183
Disease	Hamartoma Syndrome, Multiple	FGFR2 SDHC	8.10e-04	9	142	2	C0018553
Disease	mean corpuscular hemoglobin concentration	FOXO1 SWAP70 RTTN TNRC6B SIGLEC5 GADD45A NEO1 KITLG CACNA1I CLSPN MED17 MN1 CA3 BORA	9.22e-04	1105	142	14	EFO_0004528
Disease	sialic acid-binding Ig-like lectin 14 measurement	ARHGEF28 SIGLEC5	1.47e-03	12	142	2	EFO_0008284
Disease	autoimmune disease	AHI1-DT KCNH7 AFF3 GATA3 COBL	1.53e-03	173	142	5	EFO_0005140
Disease	leprosy	SIGLEC5 MAGI3 GRM7 NOD2	1.57e-03	103	142	4	EFO_0001054
Disease	nodular sclerosis Hodgkin lymphoma	GATA3 PTPRK	2.01e-03	14	142	2	EFO_0004708
Disease	1-methylurate measurement	CNTN4 GRM7	2.01e-03	14	142	2	EFO_0021173
Disease	corpus callosum posterior volume measurement	SEMA3F TNRC6B EPHA3	2.03e-03	52	142	3	EFO_0010298
Disease	Germ Cell Cancer	KITLG BUB1B	2.32e-03	15	142	2	C0740345
Disease	Embryonal Neoplasm	KITLG BUB1B	2.32e-03	15	142	2	C0027654
Disease	Neoplasms, Germ Cell and Embryonal	KITLG BUB1B	2.32e-03	15	142	2	C0027658
Disease	Germ cell tumor	KITLG BUB1B	2.32e-03	15	142	2	C0205851
Disease	Neoplasms, Embryonal and Mixed	KITLG BUB1B	2.32e-03	15	142	2	C0205852
Disease	Cancer, Embryonal	KITLG BUB1B	2.32e-03	15	142	2	C0751364
Disease	Cancer, Embryonal and Mixed	KITLG BUB1B	2.32e-03	15	142	2	C0751365
Disease	Huntington's disease (biomarker_via_orthology)	DRD1 MBP	2.64e-03	16	142	2	DOID:12858 (biomarker_via_orthology)
Disease	acute lymphoblastic leukemia	GATA3 MYRIP WDR19	4.00e-03	66	142	3	EFO_0000220
Disease	Craniosynostosis	FGFR2 MN1	4.13e-03	20	142	2	C0010278
Disease	Nonorganic psychosis	TRPM2 OPRM1 FGFR2	4.53e-03	69	142	3	C0349204
Disease	Infiltrating duct carcinoma of female breast	ANKK1 MAK	4.55e-03	21	142	2	C3165106

Protein segments in the cluster

Peptide	Gene	Start	Entry
AENIWQEQPHSKGPS	BUB1B	511	O60566
NSSKAAQAPSPWGAS	AFF3	1096	P51826
WHELFPNAKGENQSP	CA3	16	P07451
LWRGKSNNSESPHPS	ERV3-1	376	Q14264
NWIFHSTIIPPNKGS	FAM223B	76	A6NKX1
NAKSNDGWTPLHVAA	ASB7	111	Q9H672
TPPQSNHSWAVLFDG	BRICD5	96	Q6PL45
STHLDKQEWNPPAND	BOD1L2	81	Q8IYS8
DPNAAEQSGWTPLHL	ANKK1	651	Q8NFD2
HSTNGKSKPWEPFVA	GSE1	1006	Q14687
TTAQLSWRPGPDNHS	CNTN4	611	Q8IWV2
ETPSAINGNPSWHLA	BCL2L1	46	Q07817
INGNPSWHLADSPAV	BCL2L1	51	Q07817
PLITGHNSPLSKGWQ	CHI3L2	221	Q15782
HNSPLSKGWQDRGPS	CHI3L2	226	Q15782
GAAPSSALSHQGWKN	AHI1-DT	191	P0C7V0
LSWHKAKPTSPSDGN	DRD1	161	P21728
FNGPHAADPSWNSLI	ANKRD17	2556	O75179
VSAPTKSGAPWHFLS	C7orf33	86	Q8WU49
KSGAPWHFLSQGPTD	C7orf33	91	Q8WU49
TIQWPHVPSNRGSKA	LINC00301	51	Q8NCQ3
PTAPKWDSTGHSLNE	PIK3C2G	66	O75747
WKAHSTASEKDPGPQ	KCTD19	686	Q17RG1
PSQPSNVSHKLWTAA	ARHGEF28	1616	Q8N1W1
AKTHSWQDAPASAGP	OTOA	1106	Q7RTW8
SWTKDGVHLGPNNRT	FGFR2	71	P21802
IDSAAPASGSPIQHW	MUC4	5216	Q99102
ELKRGHPWNTPQVSS	LINC01548	66	A6NM66
PSPGSWVNLSHLDGN	OPRM1	26	P35372
WSSSAPNLGKSPKHT	MAP3K10	586	Q02779
VPQGWSVEALNSPHS	MAP4	186	P27816
IPDHGDWDINNPSSS	MAGI3	1106	Q5TCQ9
KNWELTASASHQPPG	IL15RA	181	Q13261
AATGHPNPQIAWQKD	LRIG1	621	Q96JA1
TTPSKPSWHLSNLNA	CHL1	971	O00533
SWISPNASEPHNASG	GPR176	6	Q14439
NAGVPLAAKSAAWHG	NAIF1	36	Q69YI7
HWQQQAPPDPAKAGT	FUBP1	516	Q96AE4
ISGPLDHSSPKRQWD	KCNH7	231	Q9NS40
SHWKQAAGAPPTATG	MAPK4	461	P31152
LPTKPLSNGSTHQLW	HMCN2	371	Q8NDA2
DAQGTPQPNITWHKD	HMCN2	3526	Q8NDA2
PQPNITWHKDGQALT	HMCN2	3531	Q8NDA2
NSWASKHPACNLPQD	C9orf131	596	Q5VYM1
QRKNHWATELPAPSS	C9orf131	676	Q5VYM1
SWGPPEQAAKHTSSK	LTBP1	241	Q14766
SQAVGAPKIPSVSWH	PEX6	691	Q13608
NWIFHSTIIPPNKGS	FAM223A	76	Q8IWN6
WPPGNKPSLHSVNQD	FYB1	131	O15117
HWALLAGPQKTNGSS	NAXD	286	Q8IW45
QLEKGHIEPSFSPWN	HERVK_113	56	P63132
FQSPSSWLSGKAHLP	HROB	301	Q8N3J3
VPPKESAGNSQWHLL	GGA3	406	Q9NZ52
KDSCSWAGPTPHTRN	GLI2	741	P10070
PGSPHWQTKLEAAQN	MED17	286	Q9NVC6
AWKDTHPDAFPNQLT	PLA2G4F	656	Q68DD2
QLEKGHIEPSFSPWN	ERVK-7	56	P63135
QLEKGHIEPSFSPWN	ERVK-6	56	Q9BXR3
PHAGAQDKFSLSAWP	KIR3DX1	21	Q9H7L2
GGHTAKISDFSWNPN	RBBP4	371	Q09028
QPGTWAPAHASALQV	PKD1L2	1796	Q7Z442
SGAVEPKDPWRHAQN	PPP1R37	56	O75864
GNKQHNSPTWDDPTL	GPRC5C	266	Q9NQ84
WKENHNSTDLLNPPG	GPR149	16	Q86SP6
AATQPAKSPGAQLWL	HERC5	21	Q9UII4
LQFTKWPDHGTPASA	PTPN20	316	Q4JDL3
QLEKGHIEPSFSPWN	ERVK-18	56	Q9QC07
SLLPEFWTSNPQHGG	FZD1	241	Q9UP38
PWNLSPFSKTSIHHG	GATA3	111	P23771
TAGKHPWQASLQSSL	HABP2	321	Q14520
LLKSHSKQPAQPGWE	GSN-AS1	66	Q9NRJ2
QFSKWPASPGSHSND	FOXO1	291	Q12778
SLAWDESLAPKHPGS	DEFA1	46	P59665
SLAWDESLAPKHPGS	DEFA3	46	P59666
ILSGNAAHWSTKPPI	CR1	596	P17927
NIDTAWSNLTHPGNK	FSTL3	66	O95633
PSAPETSWNSQHQLG	FRMPD3	1046	Q5JV73
LVTNPHSSQWKDPAL	GADD45A	126	P24522
SKPAHLNANDWATNG	FURIN	401	P09958
PADQLALFPQWKSTH	B3GALNT2	36	Q8NCR0
PSPWTDHEGKQLSQC	BORA	111	Q6PGQ7
NPVRSWLKHDSSQAP	CACNA1I	1931	Q9P0X4
WLKHDSSQAPPSPFS	CACNA1I	1936	Q9P0X4
FWNKNIGSNRPLSPH	SDHC	41	Q99643
AALAPTSWHQRGQNP	COBL	681	O75128
SSPHSETQGWKDGAQ	COBL	916	O75128
GANPNLLWSGHSPLS	ANKMY1	686	Q9P2S6
NSISLSWQEPEHPNG	EPHA3	451	P29320
GKEINPHTWSNQLFP	MAK	501	P20794
SHPIHWGSNTSKENP	IL2RG	241	P31785
ADPKNAWQDAHPADP	MBP	71	P02686
DSSESPQKHLGPVWQ	DNAI4	576	Q5VTH9
VGSDSWGSKINPLHQ	GRM7	311	Q14831
SNTPAGLQKNPIWHE	ENAM	811	Q9NRM1
GPSWASGDSSNNHKP	DCBLD1	296	Q8N8Z6
NDGETLPAPNWNLKH	FAM217A	176	Q8IXS0
LPAPNWNLKHGNSSV	FAM217A	181	Q8IXS0
LKHSTPEEAALGWSP	CCDC201	31	A0A1B0GTI1
NSPDTQRSKSHAPWE	EPB41L4A	401	Q9HCS5
QRSKSHAPWEENGPQ	EPB41L4A	406	Q9HCS5
GSHPVDNKWTPSFSS	MED1	276	Q15648
AGPPQTVSNLWNSTH	PTPRK	541	Q15262
FAWEKNPSTILNPGH	REG3G	131	Q6UW15
GAAGHQQSLPSSWKA	FAM181A	41	Q8N9Y4
QAPHLAQESAWFSGP	MN1	621	Q10571
HTPSLLLPSSWKGNS	NUTM2A	26	Q8IVF1
HTPSLLLPSSWKGNS	NUTM2B	26	A6NNL0
LLSPEKWGPQGTHQS	NUTM2B	786	A6NNL0
HTPSLLLPSSWKGNS	NUTM2E	26	B1AL46
LLSPEKWGPQGTHQS	NUTM2E	786	B1AL46
TAHLTNQWPSPGALD	RUNDC3B	351	Q96NL0
ANLTAFPGWSSHSPL	RTTN	1271	Q86VV8
GEWGKPPNQHSNSDI	TNRC6C	341	Q9HCJ0
KISNGSSINWPPEFH	TNRC6C	1376	Q9HCJ0
SSHDNFQSLPNPKSW	RAPGEF6	1371	Q8TEU7
KSQKSPWQPFPDDHS	SUPT20HL1	376	Q3ZLR7
SGLPPSGSWQDLKDH	SRSF9	116	Q13242
NPSSDLDHTWTNSKP	PRUNE2	881	Q8WUY3
SLLTGAWPSFPTQDH	SEMA3F	11	Q13275
QKIHSPSGLITSPNW	TLL1	776	O43897
RSWPSAPDDSKAQAH	PDLIM4	86	P50479
KLTWRTPASDPHGDN	NEO1	456	Q92859
WSEKAGTHPLNPANS	SLAMF1	176	Q13291
GPASHNSLPASKWAT	SIPA1L3	1086	O60292
SKWATPTTPGHAQSL	SIPA1L3	1096	O60292
PAHLSWFQGSPALNA	SIGLEC5	276	O15389
HFWEAGLAQPPSSTS	SHROOM2	726	Q13796
DCTHENGKTIPPNNW	SLC3A1	241	Q07837
NRKAKNPPGDSSLHW	KITLG	201	P21583
KPKPQATWTHNGHAL	MYBPH	201	Q13203
NWAKVGDLLPHVSSP	WDR19	881	Q8NEZ3
GASPVWAHKSAPSAS	SOX8	311	P57073
SLPSHLQLADPQGSW	NINL	1021	Q9Y2I6
NPDGKRAPWCHTTNS	PLG	326	P00747
TWAGSSQQKPAPRSH	SPAG4	71	Q9NPE6
PSQKPGASENILGWH	OSBPL10	306	Q9BXB5
KSQKSPWQPFPDDHS	SUPT20HL2	376	P0C7V6
WKHANPAAKPRAGQT	CLSPN	536	Q9HAW4
QLEKGHIEPSFSPWN	ERVK-25	56	P63136
LHNKPPVWNDDSGSY	TULP1	461	O00294
GQSQHSWPCPERSKN	LINC02912	111	Q8N9X5
AKSWDPNQLNAHPLE	TTLL8	716	A6PVC2
QADSQSPKLHGCWDP	NOD2	111	Q9HC29
GNSGNSWSHTPFPKL	RNF112	26	Q9ULX5
TANPPPQVSWHKDGS	SPEG	746	Q15772
EATKPHTFQGTQWDP	TRPM2	101	O94759
KNAWEHNSLTIPSPA	PSTK	216	Q8IV42
QLEKGHIEPSFSPWN	ERVK-10	56	P10266
QLEKGHIEPSFSPWN	ERVK-8	56	P63133
QPGAAALAWKNPISS	TMEM38B	36	Q9NVV0
PPAGHQWKEVRSDNT	TOP1MT	231	Q969P6
PLPGDDWTIFQSNHS	NDST2	221	P52849
QLEKGHIEPSFSPWN	ERVK-11	56	Q9UQG0
SKESPHWQSKSPGSS	PRRC2B	1221	Q5JSZ5
NKPWHQTTVPALATN	USF3	206	Q68DE3
NQWQHSPPKEFLLGS	SYNGR4	126	O95473
TKSAHLTNPWNEHKP	YTHDC1	456	Q96MU7
GSNWDLPTQETHTPA	ZNF648	196	Q5T619
SHSPSSWGSLPFLKN	SPZ1	41	Q9BXG8
SGLPPSGSWQDLKDH	SRSF1	126	Q07955
GSKNPHLITNWGPAA	SWAP70	551	Q9UH65
QLEKGHIEPSFSPWN	ERVK-19	56	Q9WJR5
EKHPGQALSSEPWNF	TGS1	216	Q96RS0
APSQTHPWRSASGKS	TMC2	886	Q8TDI7
QHNLLSPPFGWASGS	UBR4	881	Q5T4S7
NNGTSPNPIHIWDKV	TNRC6B	176	Q9UPQ9
PNSSTGAWDNQKGHP	TNRC6B	531	Q9UPQ9
SPLNTHAAELWKNPT	UBE2C	146	O00762
GQHPRAESALPSWKS	MYRIP	321	Q8NFW9
LDTFGHLKDSNSWPP	PPP1R9A	246	Q9ULJ8
HLKDSNSWPPSNKRG	PPP1R9A	251	Q9ULJ8