Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainM_domain

TNRC6A TNRC6C

1.38e-052702PF12938
DomainGW182_M_dom

TNRC6A TNRC6C

1.38e-052702IPR026805
DomainAgo_hook

TNRC6A TNRC6C

4.14e-053702PF10427
DomainTNRC6_PABC-bd

TNRC6A TNRC6C

4.14e-053702IPR032226
DomainArgonaute_hook_dom

TNRC6A TNRC6C

4.14e-053702IPR019486
DomainTNRC6-PABC_bdg

TNRC6A TNRC6C

4.14e-053702PF16608
DomainUBA-like

UBAP2L TNRC6A TAB2 TNRC6C

9.70e-0564704IPR009060
DomainCalpain_III

CAPN12 CAPN11

8.92e-0412702IPR022683
Domaincalpain_III

CAPN12 CAPN11

8.92e-0412702SM00720
DomainC2_III

CAPN12 CAPN11

8.92e-0412702IPR033883
DomainABC_A

ABCA2 ABCA7

8.92e-0412702IPR026082
DomainCalpain_domain_III

CAPN12 CAPN11

1.05e-0313702IPR022682
DomainCalpain_III

CAPN12 CAPN11

1.05e-0313702PF01067
DomainCalpain_cysteine_protease

CAPN12 CAPN11

1.22e-0314702IPR022684
DomainCysPc

CAPN12 CAPN11

1.41e-0315702SM00230
DomainPeptidase_C2_calpain_cat

CAPN12 CAPN11

1.41e-0315702IPR001300
DomainPeptidase_C2

CAPN12 CAPN11

1.41e-0315702PF00648
DomainCALPAIN_CAT

CAPN12 CAPN11

1.41e-0315702PS50203
DomainRCC1

IBTK HERC2

2.52e-0320702PF00415
DomainRCC1_1

IBTK HERC2

2.78e-0321702PS00625
DomainRCC1_2

IBTK HERC2

2.78e-0321702PS00626
DomainRCC1_3

IBTK HERC2

2.78e-0321702PS50012
DomainReg_chr_condens

IBTK HERC2

3.05e-0322702IPR000408
Domain-

IBTK HERC2

3.05e-03227022.130.10.30
DomainRCC1/BLIP-II

IBTK HERC2

3.33e-0323702IPR009091
DomainEphrin_rec_like

EPHB6 ELAPOR1

3.93e-0325702SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB6 ELAPOR1

3.93e-0325702IPR011641
DomainTHIOL_PROTEASE_CYS

CAPN12 CAPN11

4.25e-0326702PS00139
DomainTHIOL_PROTEASE_ASN

CAPN12 CAPN11

4.57e-0327702PS00640
DomainTHIOL_PROTEASE_HIS

CAPN12 CAPN11

4.57e-0327702PS00639
DomainPept_cys_AS

CAPN12 CAPN11

4.91e-0328702IPR000169
DomainUBA

UBAP2L TNRC6C

5.63e-0330702SM00165
Domain-

COL18A1 CLEC4G PKD1L3

5.78e-03977033.10.100.10
DomainC-type_lectin-like/link

COL18A1 CLEC4G PKD1L3

6.12e-0399703IPR016186
DomainGPS

ADGRV1 PKD1L3

7.19e-0334702SM00303
Domain-

EPHB6 ETS2 KIF24

7.38e-031067031.10.150.50
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

ABCA2 SDK2 ADGRV1 HERC2 ABCA7

1.03e-068474515203218
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ST6GAL2 IBTK ABCA2 SDK2 CECR2 PHRF1 TNRC6A ADGRV1 HOMEZ

1.87e-0652974914621295
Pubmed

Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor.

DAXX MEN1

1.34e-05374232345369
Pubmed

Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.

DAXX MEN1

1.34e-05374227872097
Pubmed

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup.

DAXX MEN1

1.34e-05374230315258
Pubmed

Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.

DAXX MEN1

1.34e-05374232821827
Pubmed

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

TNRC6A TNRC6C

1.34e-05374234108231
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6A TNRC6C

1.34e-05374216880270
Pubmed

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

TNRC6A TNRC6C

1.34e-05374231670606
Pubmed

The genetics of neuroendocrine tumors.

DAXX MEN1

1.34e-05374223391111
Pubmed

NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.

TEAD4 TRIM27

1.34e-05374233993634
Pubmed

An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

GPR173 GPR85

1.34e-05374210833454
Pubmed

Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.

CD101 IL9R

2.67e-05474225421756
Pubmed

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.

TNRC6A TNRC6C

2.67e-05474223172285
Pubmed

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.

COL18A1 WNT4

2.67e-05474232218432
Pubmed

Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.

DAXX MEN1

2.67e-05474235976056
Pubmed

SUMO regulates the cytoplasmonuclear transport of its target protein Daxx.

DAXX TRIM27

2.67e-05474216475184
Pubmed

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

TNRC6A TNRC6C

2.67e-05474221063388
Pubmed

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.

PPM1K CDC20

2.67e-05474229719258
Pubmed

Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation.

TAB2 TRIM27

2.67e-05474232343849
Pubmed

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.

TNRC6A TNRC6C

2.67e-05474220181956
Pubmed

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.

DAXX MEN1

6.66e-05674221252315
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

IBTK TNRC6A NUBP1 TAB2 CPD TNRC6C HERC2 SNX9 MEN1

8.19e-0585374928718761
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

TNRC6A TNRC6C

9.31e-05774219470757
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

TNRC6A TNRC6C

9.31e-05774219383768
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

IBTK TRIM56 TNRC6A TAB2 TNRC6C

1.05e-0421874533378226
Pubmed

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.

TNRC6A TNRC6C

1.24e-04874224768540
Pubmed

Daxx regulates mitotic progression and prostate cancer predisposition.

DAXX CDC20

1.24e-04874223239745
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA2 ABCA7

1.24e-04874224293640
Pubmed

SUMO E3 ligase activity of TRIM proteins.

DAXX TRIM27

1.24e-04874220972456
Pubmed

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

DPH1 DIAPH2

1.24e-04874218931663
Pubmed

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

TNRC6A TNRC6C

1.99e-041074221984185
Pubmed

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.

TNRC6A TNRC6C

2.43e-041174221984184
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

COL18A1 B3GNTL1 UBAP2L CPD RIMS1 WNT4 TNRC6C ADGRV1 PPM1K SNX9 TET3

2.99e-041489741128611215
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

COL18A1 MAN1A1 GGCT RENBP ADGRV1 PKD1L3 GDF2 SNX9 PGD

3.02e-04101674919056867
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

IBTK ELAPOR1 UNC79 HOMEZ

3.26e-0415374410718198
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

CECR2 TET3

3.43e-041374226989192
Pubmed

The DNA sequence and analysis of human chromosome 6.

IBTK MAN1A1 TAB2 DAXX TRIM27 SNX9 SOD2

3.61e-0462274714574404
Pubmed

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

TNRC6A TNRC6C

4.00e-041474219716330
Pubmed

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

TNRC6A TNRC6C

4.61e-041574221981923
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

IBTK UBAP2L CECR2 TNRC6A PRDM12 UNC79

4.97e-0446974627634302
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

EPHB6 SPTBN5 TRIM56 PHRF1 EIF2S2 DAXX

6.67e-0449674631343991
Pubmed

Wnt signaling and Dupuytren's disease.

TAB2 WNT4

6.68e-041874221732829
Pubmed

Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.

UBAP2L TAB2

6.68e-041874227695001
Pubmed

Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia.

WNT4 FOXI1

6.68e-041874223704941
Pubmed

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.

ABCA2 SOD2

8.28e-042074221072184
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

IBTK UBAP2L TNRC6A DAXX CDC20 TRIM27 SNX9

8.85e-0472474736232890
Pubmed

Genetic mapping in mammals: chromosome map of domestic cat.

PGD SOD2

9.14e-04217427063884
Pubmed

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

TRIM56 TRIM27

9.14e-042174218248090
Pubmed

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.

COL18A1 UBAP2L TEAD4

9.82e-049174330472188
Pubmed

Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.

TNRC6A TNRC6C

1.00e-032274222187428
Pubmed

Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.

COL18A1 GDF2 SOD2

1.08e-039474320346360
Pubmed

Gene map of the cow: conservation of linkage with mouse and man.

PGD SOD2

1.10e-03237423082971
Pubmed

Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.

TNRC6A TNRC6C

1.10e-032374228811219
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

PHRF1 HERC2 TRIM27

1.11e-039574329643511
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

COL18A1 TRIM56 PHRF1 EIF2S2 TNRC6A ELAPOR1 DAXX HERC2 TRIM27 MEN1

1.24e-031497741031527615
Pubmed

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.

TNRC6A TRIM27

1.30e-032574232528060
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

TNRC6A NUBP1 HERC2 TRIM27

1.33e-0322374434226595
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SDK2 PHRF1 TNRC6A

1.40e-0310374310819331
Pubmed

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.

ETS2 HERC2 SOD2

1.40e-0310374311752456
Pubmed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.

WNT4 FOXI1

1.40e-032674219060336
Pubmed

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.

WNT4 FOXI1

1.40e-032674220944551
Pubmed

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.

ADGRV1 HERC2

1.51e-032774234709416
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

IBTK UBAP2L TNRC6A

1.57e-0310774330995489
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

TNRC6A TAB2 DAXX CDC20 SNX9 RBM20

1.59e-0358874638580884
Pubmed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.

DAXX WNT4 TEAD4 TRIM27 SNX9

2.02e-0341974527107012
Pubmed

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.

TEAD4 CDC20

2.13e-033274230487608
Cytoband1p36.22

C1orf167 PGD

1.65e-03377421p36.22
CytobandEnsembl 112 genes in cytogenetic band chr6q25

TAB2 SNX9 SOD2

2.41e-03164743chr6q25
GeneFamilyATP binding cassette subfamily A

ABCA2 ABCA7

7.79e-0414542805
GeneFamilyC2 domain containing|Calpains

CAPN12 CAPN11

8.97e-0415542975
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6A TNRC6C

2.51e-0325542775
DiseasePancreatic Endocrine Carcinoma

DAXX MEN1

1.76e-053722C1328479
Diseaseovary epithelial cancer (is_implicated_in)

TAB2 DAXX

3.18e-0411722DOID:2152 (is_implicated_in)
DiseaseNeuroendocrine Tumors

DAXX MEN1

3.18e-0411722C0206754
DiseaseAdrenocortical carcinoma

DAXX MEN1

8.76e-0418722C0206686
Diseasecardiomyopathy (is_implicated_in)

TAB2 SOD2

9.77e-0419722DOID:0050700 (is_implicated_in)
DiseasePancreatic Neoplasm

DAXX SOD2 MEN1

1.90e-03100723C0030297
DiseaseMalignant neoplasm of pancreas

DAXX SOD2 MEN1

2.01e-03102723C0346647

Protein segments in the cluster

PeptideGeneStartEntry
TGSFPQAWHSTAAGV

C1orf167

656

Q5SNV9
GEGGWVPLQTFTQHQ

CDC20

341

Q12834
GGDWSHSQSQLGTPG

LINC00696

141

Q6ZRV3
RNGGTHGNVSANWVL

ADGRV1

421

Q8WXG9
LHQWPTADFQGGGTT

CFAP46

1081

Q8IYW2
ETQWQTPGQFNPGHF

CYP2W1

396

Q8TAV3
PGQFIHTNWTGHGGT

PGD

461

P52209
GFWQTRQGGSPAKQT

ARSG

321

Q96EG1
GGCRNHPGTFWTNPQ

CAPN11

406

Q9UMQ6
TSNPVSWVNNFGHEG

DIAPH2

191

O60879
YAGSSLGPWTVNHGQ

DPH1

386

Q9BZG8
GVYWQNGLSPGVQST

ANXA2R

66

Q3ZCQ2
SAVWNGNHGATNQGP

CECR2

791

Q9BXF3
NQWTEQSGFLPHGVP

CECR2

841

Q9BXF3
TSFNGGVSPHNWGDS

DAXX

611

Q9UER7
GEGAQWHNVGTRPTA

ABCA7

711

Q8IZY2
LLQGTNSQWESPHGF

RBM20

311

Q5T481
NSQWESPHGFSGQSK

RBM20

316

Q5T481
GGFVAWNSLGQPHVN

PPM1K

241

Q8N3J5
QSWGRGSAGGNAHSP

GDF2

26

Q9UK05
FGPNGEQTAEVTWHG

MEN1

191

O00255
EGEQVHQSGSGWSPV

NUBP1

106

P53384
WNGIEPSATAQGGNA

FBXW10B

686

O95170
WVQDNIASFGGNPGS

CES1P1

201

Q9UKY3
GRQQNPGHTLEAGWF

RENBP

251

P51606
WGDNDHGQQGNGTTT

HERC2

3281

O95714
TWGDNTNFTLGHGSQ

IBTK

146

Q9P2D0
WAGTAFQVTQGTGPE

ELAPOR1

31

Q6UXG2
SAEPQWFSNTGAPGH

FAM124A

376

Q86V42
SWEQNTNHGAAGVPF

PCDHGB2

786

Q9Y5G2
TGFGPFGEHTVNASW

PGPEP1

11

Q9NXJ5
HPWSGTGQVVYNGSI

OLFM1

296

Q99784
SGAWVSHVANSVGPG

COL18A1

301

P39060
SVPHWINSNTLGFGT

ETS2

186

P15036
VPGFRQSHSPWFNGT

PHRF1

621

Q9P1Y6
SEDSFFLHQTWGQGP

KIF24

851

Q5T7B8
SQTWHGGIATIFQSP

GGCT

61

O75223
PIGNSSNNSSHWDLG

KCNK10

141

P57789
WYGNSHNTFLGIPGV

PRDM12

201

Q9H4Q4
GISFSNQTGPAWAGS

EIF2S2

156

P20042
GAWFFGSGPQQTSQD

RIMS1

176

Q86UR5
GFNSGGSQPNAETFW

CAPN12

366

Q6ZSI9
PSQGTEHSGWAATFQ

CEFIP

86

Q711Q0
TGHQGPSEQHFQWSV

CD101

46

Q93033
HGITNGASWYNVPGG

CPD

731

O75976
AGVGIQWHTFSQSPV

ABCA2

871

Q9BZC7
ISQNWTFHGPGATGQ

GPR173

226

Q9NS66
TFHGPGATGQAAANW

GPR173

231

Q9NS66
PSSGQWGQHHVSVGG

MAN1A1

396

P33908
VAAVSQNWTFHGPGA

GPR85

221

P60893
QNWTFHGPGASGQAA

GPR85

226

P60893
HGPGASGQAAANWLA

GPR85

231

P60893
TNLSNHSGGGDWANP

FOXI1

326

Q12951
GPNQSHGIGTASWNH

HOMEZ

236

Q8IX15
QQAWSPHSTGPTGGS

HPS1

271

Q92902
QAFNAIGSGPWSQTV

SDK2

1176

Q58EX2
WPQGAHGEGSLASSQ

NUTM2A

301

Q8IVF1
SNNHQVGSGNDPWSA

SNX9

96

Q9Y5X1
GGVTSAPQNGFWAVS

TRIM27

396

P14373
GAWGHPSRSTSNGVN

TNRC6C

326

Q9HCJ0
TPGGTTRQTQQHSGW

TAB2

221

Q9NYJ8
PPGTGQDNWLQTHFV

EPHB6

81

O15197
HNQTWSSAGCQVGPQ

PKD1L3

641

Q7Z443
GQPGWHSHTQGTLGF

ST6GAL2

136

Q96JF0
GWHLSALPGNTQSSG

IL9R

451

Q01113
FQEPQGGGHWSQVQT

ITGAL

436

P20701
SFQWRPSGHQGLGAQ

SPTBN5

3506

Q9NRC6
RAWFSHVGPFNEGGQ

B3GNTL1

186

Q67FW5
DGVSLSFSHWNQGEP

CLEC4G

241

Q6UXB4
NSSGNTWNNTGHFEP

UBAP2L

216

Q14157
INHSIFWTNLSPNGG

SOD2

96

P04179
SQNGGPSHLWGQYSG

TET3

1426

O43151
GFWQGALPGQAGTSH

TEAD4

161

Q15561
TVHGVSPQGFQWSGC

WNT4

141

P56705
SGHSSVSWYQQAPGQ

TRBV5-3

46

A0A0A0MS03
SNNVGHGSSTGPWGF

TNRC6A

301

Q8NDV7
RHPGWGQQSAAGFQQ

nan

171

Q6ZTC4
TTSPQGHFVGSDWQQ

TRIM56

641

Q9BRZ2
NNVFQAPWGGSHTCQ

UNC79

836

Q9P2D8
HTLFSGQPGPNWQAV

ZAN

316

Q9Y493
ATAWHGFGENGNLSP

ZNF554

216

Q86TJ5