Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H2AXS139 kinase activity	ATR PRKDC	4.39e-05	3	77	2	GO:0035979
GeneOntologyMolecularFunction	histone H2AX kinase activity	ATR PRKDC	1.46e-04	5	77	2	GO:0141003
GeneOntologyMolecularFunction	histone kinase activity	ATR BUB1 PRKDC	1.69e-04	28	77	3	GO:0035173
GeneOntologyMolecularFunction	histone modifying activity	ATR MCM3AP SETBP1 BUB1 SETD4 PRKDC	2.56e-04	229	77	6	GO:0140993
GeneOntologyCellularComponent	dynein complex	DYNLT2B DNAH2 DNAL1 DNAI7	4.92e-05	54	78	4	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH2 DNAL1 DNAI7	1.08e-04	25	78	3	GO:0005858
GeneOntologyCellularComponent	microtubule associated complex	DYNLT2B KIF6 DNAH2 DNAL1 DNAI7	3.42e-04	161	78	5	GO:0005875
GeneOntologyCellularComponent	inner dynein arm	DNAH2 DNAI7	6.07e-04	10	78	2	GO:0036156
GeneOntologyCellularComponent	axoneme	DYNLT2B GLI2 DNAH2 DNAL1 DNAI7	1.07e-03	207	78	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	DYNLT2B GLI2 DNAH2 DNAL1 DNAI7	1.09e-03	208	78	5	GO:0097014
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	DYNLT2B RANBP1 GLI2 DNAH2 DNAL1 DNAI7	1.19e-03	317	78	6	GO:0032838
Domain	FATC	ATR PRKDC	1.54e-04	5	74	2	PF02260
Domain	ZnF_U1	ZNF385D ZNF346 ZMAT1	2.03e-04	29	74	3	SM00451
Domain	Znf_U1	ZNF385D ZNF346 ZMAT1	2.03e-04	29	74	3	IPR003604
Domain	FAT	ATR PRKDC	2.30e-04	6	74	2	PS51189
Domain	FATC	ATR PRKDC	2.30e-04	6	74	2	PS51190
Domain	FAT	ATR PRKDC	2.30e-04	6	74	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR PRKDC	2.30e-04	6	74	2	IPR003151
Domain	FATC_dom	ATR PRKDC	2.30e-04	6	74	2	IPR003152
Domain	PIK_FAT	ATR PRKDC	2.30e-04	6	74	2	IPR014009
Domain	FATC	ATR PRKDC	2.30e-04	6	74	2	SM01343
Domain	Znf_C2H2_matrin	ZNF385D ZNF346	9.96e-04	12	74	2	IPR000690
Domain	PI3/4_kinase_CS	ATR PRKDC	1.57e-03	15	74	2	IPR018936
Domain	-	ATR PRKDC	1.79e-03	16	74	2	1.10.1070.11
Domain	PI3Kc	ATR PRKDC	1.79e-03	16	74	2	SM00146
Domain	AT_hook	PRR12 SETBP1	1.79e-03	16	74	2	PF02178
Domain	PI3/4_kinase_cat_dom	ATR PRKDC	2.27e-03	18	74	2	IPR000403
Domain	PI3_PI4_kinase	ATR PRKDC	2.27e-03	18	74	2	PF00454
Domain	ZF_MATRIN	ZNF385D ZNF346	2.27e-03	18	74	2	PS50171
Domain	PI3_4_KINASE_3	ATR PRKDC	2.27e-03	18	74	2	PS50290
Domain	PI3_4_KINASE_1	ATR PRKDC	2.27e-03	18	74	2	PS00915
Domain	PI3_4_KINASE_2	ATR PRKDC	2.27e-03	18	74	2	PS00916
Domain	TPR-like_helical_dom	ZC3H7A ATR EEF2K PRKDC ZFC3H1	2.32e-03	233	74	5	IPR011990
Domain	TPR_REGION	ZC3H7A DNAH2 PRKDC ZFC3H1	4.18e-03	165	74	4	PS50293
Domain	TPR	ZC3H7A DNAH2 PRKDC ZFC3H1	4.18e-03	165	74	4	PS50005
Domain	AT_hook	PRR12 SETBP1	5.10e-03	27	74	2	SM00384
Domain	AT_hook_DNA-bd_motif	PRR12 SETBP1	5.10e-03	27	74	2	IPR017956
Domain	HMGI/Y_DNA-bd_CS	PRR12 SETBP1	6.69e-03	31	74	2	IPR000637
Domain	SNF2_N	SMARCA1 CHD4	7.11e-03	32	74	2	IPR000330
Domain	SNF2_N	SMARCA1 CHD4	7.11e-03	32	74	2	PF00176
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	SLC8A1 ATP2B2 ITPR2	1.38e-04	27	53	3	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	SLC8A1 ATP2B2 ITPR2	1.54e-04	28	53	3	M924
Pathway	REACTOME_PLATELET_HOMEOSTASIS	SLC8A1 NOS2 ATP2B2 ITPR2	1.87e-04	76	53	4	MM15051
Pathway	REACTOME_PLATELET_HOMEOSTASIS	SLC8A1 NOS2 ATP2B2 ITPR2	3.01e-04	86	53	4	M916
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	SLC8A1 ATP2B2 ITPR2	3.28e-04	36	53	3	M39831
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TARDBP KIDINS220 AMOTL1 MCM3 EEF2K CHD4 PRKDC OCLN ZMAT1 PCM1 HP1BP3	1.29e-06	777	78	11	35844135
Pubmed	Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice.	CD34 PRKDC	4.97e-06	2	78	2	8652806
Pubmed	Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization.	MCM3AP MCM3	4.97e-06	2	78	2	9712829
Pubmed	MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.	MCM3AP MCM3	4.97e-06	2	78	2	11258703
Pubmed	DNA structure-specific priming of ATR activation by DNA-PKcs.	ATR PRKDC	4.97e-06	2	78	2	23897887
Pubmed	Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.	PRKDC NOS2	4.97e-06	2	78	2	11426950
Pubmed	A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication.	MCM3AP MCM3	4.97e-06	2	78	2	10733502
Pubmed	Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.	PRKDC NOS2	4.97e-06	2	78	2	17982083
Pubmed	Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication.	MCM3AP MCM3	4.97e-06	2	78	2	11024281
Pubmed	The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3.	MCM3AP MCM3	4.97e-06	2	78	2	12226073
Pubmed	Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.	RANBP1 BUB1 WDR48	8.64e-06	18	78	3	28689657
Pubmed	DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro.	TARDBP PRKDC	1.49e-05	3	78	2	28832631
Pubmed	Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.	ATR PRKDC	1.49e-05	3	78	2	9766667
Pubmed	Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.	ATR PRKDC	1.49e-05	3	78	2	18451257
Pubmed	Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.	ATR CEP164	1.49e-05	3	78	2	18283122
Pubmed	DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.	ATR PRKDC	1.49e-05	3	78	2	27733644
Pubmed	GANP regulates the choice of DNA repair pathway by DNA-PKcs interaction in AID-dependent IgV region diversification.	MCM3AP PRKDC	1.49e-05	3	78	2	24808370
Pubmed	Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.	ATR PRKDC	1.49e-05	3	78	2	19444312
Pubmed	Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase.	ATR PRKDC	1.49e-05	3	78	2	26365377
Pubmed	DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.	ATR PRKDC	1.49e-05	3	78	2	31601897
Pubmed	PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.	ZFC3H1 PAPOLG	1.49e-05	3	78	2	37875486
Pubmed	A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.	NOS2 NLRC4	1.49e-05	3	78	2	20702413
Pubmed	Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase.	ATR PRKDC	1.49e-05	3	78	2	31164689
Pubmed	MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR.	MCM3AP MCM3	1.49e-05	3	78	2	12167160
Pubmed	Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.	TARDBP RANBP1	1.49e-05	3	78	2	25743254
Pubmed	Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.	PRKDC NOS2	1.49e-05	3	78	2	21576322
Pubmed	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.	PRKDC NOS2	1.49e-05	3	78	2	21576342
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	SLC8A1 SYNE1 PCM1	2.41e-05	25	78	3	38877142
Pubmed	SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.	ATR PRKDC	2.97e-05	4	78	2	15998665
Pubmed	A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.	PRKDC NOS2	2.97e-05	4	78	2	10878373
Pubmed	Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.	PRKDC NOS2	2.97e-05	4	78	2	16365445
Pubmed	G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.	PRKDC NOS2	2.97e-05	4	78	2	25834108
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	NAB1 CHD4	2.97e-05	4	78	2	16574654
Pubmed	PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.	ATR PRKDC	2.97e-05	4	78	2	29309644
Pubmed	Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.	ATR PRKDC	4.94e-05	5	78	2	19596237
Pubmed	Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.	ATR PRKDC	4.94e-05	5	78	2	16540648
Pubmed	Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.	PRKDC NOS2	4.94e-05	5	78	2	9144497
Pubmed	Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.	PRKDC NOS2	4.94e-05	5	78	2	10950807
Pubmed	Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.	DNAH2 DNAI7	4.94e-05	5	78	2	30060180
Pubmed	ATR is a multifunctional regulator of male mouse meiosis.	ATR PRKDC	4.94e-05	5	78	2	29976923
Pubmed	ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.	ATR MCM3	4.94e-05	5	78	2	25843623
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZC3H7A MBTD1 MCM3AP BUB1 MCM3 DNMBP PCM1 PAPOLG	5.28e-05	588	78	8	38580884
Pubmed	The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.	ATR PRKDC	7.40e-05	6	78	2	10951572
Pubmed	The complexity of p53 modulation: emerging patterns from divergent signals.	ATR PRKDC	7.40e-05	6	78	2	9765199
Pubmed	Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.	ATR MCM3	7.40e-05	6	78	2	15210935
Pubmed	T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.	PRKDC NOS2	7.40e-05	6	78	2	27622331
Pubmed	Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.	ATR PRKDC	7.40e-05	6	78	2	11883897
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	SLC8A1 ATP2B2	7.40e-05	6	78	2	12767889
Pubmed	The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3.	TRIM11 NLRC4	7.40e-05	6	78	2	34512673
Pubmed	Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.	RANBP1 PRKDC SERPIND1	7.98e-05	37	78	3	10337614
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	SLC8A1 ATP2B2 ITPR2	8.65e-05	38	78	3	30786075
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KIDINS220 CHD4 PRKDC ZFC3H1 ATP2B2	9.41e-05	202	78	5	24639526
Pubmed	Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.	ATR PRKDC	1.04e-04	7	78	2	20818375
Pubmed	Telomere protection by TPP1/POT1 requires tethering to TIN2.	ATR PRKDC	1.04e-04	7	78	2	22099311
Pubmed	Centrosomal localization of DNA damage checkpoint proteins.	ATR PRKDC	1.04e-04	7	78	2	17171639
Pubmed	Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.	ATR CHD4	1.04e-04	7	78	2	10545197
Pubmed	The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.	ATR PRKDC	1.04e-04	7	78	2	10673501
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SECISBP2L PRR12 TAOK3 MIA3 ATR BUB1 HP1BP3 WDR48	1.06e-04	650	78	8	38777146
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZC3H7A MIA3 KIDINS220 ERAP2 SYNE1 RAB3GAP2 EEF2K ZFC3H1 OCLN PCM1 HP1BP3 ITPR2	1.14e-04	1487	78	12	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DYNLT2B MIA3 KIDINS220 FAM111A MID2 GLI2 RIN2 SETBP1 DENND1A ZMAT1 PCM1 HP1BP3	1.15e-04	1489	78	12	28611215
Pubmed	The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.	TARDBP CHD4 PRKDC	1.17e-04	42	78	3	34244791
Pubmed	Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.	ATR PRKDC	1.38e-04	8	78	2	15456891
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	SLC8A1 ITPR2	1.38e-04	8	78	2	21737792
Pubmed	Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.	ATR PRKDC	1.38e-04	8	78	2	22184063
Pubmed	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction.	PRKDC PCM1	1.38e-04	8	78	2	29946151
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	ATR PRKDC	1.38e-04	8	78	2	20810650
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 MBTD1 MCM3AP NAB1 SMARCA1 PAGR1	1.41e-04	351	78	6	38297188
Pubmed	Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.	TARDBP TRIM11 HP1BP3	1.54e-04	46	78	3	34767673
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 RAB3GAP2 SETBP1 SLIT1 WDR48	1.56e-04	225	78	5	12168954
Pubmed	Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.	PRKDC NOS2	1.77e-04	9	78	2	16239576
Pubmed	Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.	ATR PRKDC	1.77e-04	9	78	2	10747897
Pubmed	Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis.	SLC8A1 CD34	1.77e-04	9	78	2	35264563
Pubmed	Generation and analysis of 280,000 human expressed sequence tags.	CD34 RAB3GAP2 CHD4 DNMBP ZMAT1 GOLGA1	1.82e-04	368	78	6	8889549
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	ATR PRKDC	2.21e-04	10	78	2	18160036
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	TAOK3 ATR	2.21e-04	10	78	2	17478428
Pubmed	E3 ligase RFWD3 participates in replication checkpoint control.	MCM3 PRKDC	2.21e-04	10	78	2	21504906
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	TARDBP MCM3 CHD4 PRKDC	2.21e-04	131	78	4	34551306
Pubmed	Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.	SMARCA1 CHD4 PRKDC	2.34e-04	53	78	3	36841324
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TARDBP RANBP1 RAB3GAP2 AMOTL1 MCM3 PRKDC PCM1	2.36e-04	549	78	7	38280479
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR PRKDC	2.70e-04	11	78	2	20427287
Pubmed	IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.	NOS2 NLRC4	2.70e-04	11	78	2	27693356
Pubmed	Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.	ATR PRKDC	2.70e-04	11	78	2	15758953
Pubmed	UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.	ATR PRKDC	2.70e-04	11	78	2	11709713
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	GLI2 SYNE1	2.70e-04	11	78	2	27621083
Pubmed	Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.	PRKDC NOS2	2.70e-04	11	78	2	28973896
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	ATR PRKDC	2.70e-04	11	78	2	11551930
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	AMOTL1 MCM3 CHD4	2.91e-04	57	78	3	38223760
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIDINS220 SYNE1 RAB3GAP2 MCM3AP SLIT1 WDR48	3.13e-04	407	78	6	12693553
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TARDBP RANBP1 KIDINS220 ATR SYNE1 RAB3GAP2 SMARCA1 MCM3 CHD4 PRKDC STX16	3.29e-04	1425	78	11	30948266
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATR MCM3 CHD4 PAGR1 PRKDC DNMBP PCM1 PAPOLG	3.45e-04	774	78	8	15302935
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	MIA3 FAM111A GLI2 CHD4 PRKDC ZFC3H1 RMND1 OCLN STX16 HP1BP3	3.52e-04	1203	78	10	29180619
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ZC3H7A TARDBP RANBP1 SYNE1 DNAH2 SMARCA1 CHD4 PRKDC ZFC3H1 ATP2B2 HP1BP3	3.64e-04	1442	78	11	35575683
Pubmed	Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.	NOS2 NLRC4	3.81e-04	13	78	2	25166912
Pubmed	Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.	TARDBP SETBP1	3.81e-04	13	78	2	22693459
Pubmed	Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion.	GLI2 SLIT1	3.81e-04	13	78	2	25366972
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	TARDBP RANBP1 SYNE1 SMARCA1 MCM3 CHD4 PRKDC HP1BP3	4.40e-04	803	78	8	36517590
Pubmed	Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.	NOS2 NLRC4	4.44e-04	14	78	2	26320999
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	TARDBP MIA3 SYNE1 MCM3 CHD4 PRKDC STX16 HP1BP3	4.55e-04	807	78	8	30575818
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	MIA3 ATR MID2 PCM1 ITPR2	4.62e-04	285	78	5	32838362
Pubmed	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.	CEP164 PCM1	5.12e-04	15	78	2	24469809
Cytoband	2q14	GLI2 BUB1	1.55e-04	11	78	2	2q14
Coexpression	GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_UP	SLC8A1 NAB1 DNAH2 GOLGA1 PDZRN4 WDR48	2.74e-05	197	78	6	M6278
Coexpression	GSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN	MIA3 KIDINS220 RMND1 GOLGA1 ITPR2 PAPOLG	2.90e-05	199	78	6	M316
Coexpression	GSE14308_TH1_VS_TH17_DN	MIA3 KIDINS220 RAB3GAP2 PRKDC ZFC3H1 WDR48	2.98e-05	200	78	6	M3374
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	TAOK3 KIDINS220 RIN2 BUB1 SMARCA1 MXI1	2.98e-05	200	78	6	M4538
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SLC8A1 STX16 DNMBP ZMAT1 ITPR2 PAPOLG	9.53e-07	187	78	6	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RANBP1 FAM111A CD34 BUB1 MCM3	1.49e-05	177	78	5	8a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNLT2B BUB1 DNAL1 DNAI7 PCM1	2.10e-05	190	78	5	da60bcc4b59d8e3719d8201387d567594059b1a4
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNLT2B BUB1 DNAL1 DNAI7 PCM1	2.10e-05	190	78	5	827a1f4e4ac4beada262f4fb965dd74a447a8f4f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNLT2B BUB1 DNAL1 DNAI7 PCM1	2.15e-05	191	78	5	a6c9df4cb4d09e0a91b3c8d7f3e091a7e95e6471
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 MIA3 ABCA5 CHD4 PCM1	2.37e-05	195	78	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DNAH2 DNAL1 DNAI7 PCM1	2.49e-05	197	78	5	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DNAH2 DNAL1 DNAI7 PCM1	2.49e-05	197	78	5	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF6 SYNE1 DNAH2 CCDC175 DNAI7	2.49e-05	197	78	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DNAH2 DNAL1 DNAI7 PCM1	2.49e-05	197	78	5	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 DNAH2 DNAL1 DNAI7 PCM1	2.49e-05	197	78	5	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pre_pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DYNLT2B RANBP1 FAM111A BUB1 MCM3	2.61e-05	199	78	5	99778178e3ec121802db938db8c5475d19b43fec
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	RANBP1 FAM111A BUB1 MCM3 PRKDC	2.68e-05	200	78	5	548a0f486ab8745da107f2815914dbf873a6e3c8
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF385D GLI2 CD34 SETBP1 PDZRN4	2.68e-05	200	78	5	74e74123ea7bf38d337a3a0248a6a51437c6ab42
Disease	urate measurement, bone density	SLC26A8 KIF6 KIDINS220 GLI2 SYNE1 CD34 A2ML1 PRKDC DENND1A ATP2B2 ITPR2	5.28e-07	619	76	11	EFO_0003923, EFO_0004531
Disease	Spastic Paraplegia	RAB3GAP2 WDR48	2.33e-04	9	76	2	C0037772
Disease	Silicosis	NOS2 PDZRN4	2.33e-04	9	76	2	C0037116
Disease	Colorectal Carcinoma	ZNF385D ABCA5 SYNE1 MCM3AP SETBP1 BUB1 SETD4 PDZRN4	4.48e-04	702	76	8	C0009402
Disease	Alzheimer's disease (is_marker_for)	TARDBP SLC8A1 ATR EEF2K NOS2	5.38e-04	257	76	5	DOID:10652 (is_marker_for)
Disease	central nervous system disease (implicated_via_orthology)	TAOK3 SMARCA1	7.67e-04	16	76	2	DOID:331 (implicated_via_orthology)
Disease	interleukin 18 measurement	PRR12 OCLN NLRC4	1.01e-03	76	76	3	EFO_0004581
Disease	treatment resistant depression, response to antidepressant	ZNF385D SLIT1	1.33e-03	21	76	2	EFO_0009854, GO_0036276
Disease	Uterine leiomyoma	ZNF346 SYNE1 DNAH2	1.70e-03	91	76	3	HP_0000131
Disease	Myocardial Infarction	KIF6 MIA3 NOS2	1.92e-03	95	76	3	C0027051
Disease	Retinal Diseases	OCLN NOS2	2.20e-03	27	76	2	C0035309

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTKHAKKLKALEAMK	ZNF385D	101	Q9H6B1
KKIKEFLKIMGLHDT	ABCA5	246	Q8WWZ7
MKKLIAQKPDLKIHD	ADAL	36	Q6DHV7
LKIHDQMTVIDKGKK	ADAL	46	Q6DHV7
IKDRIKKLLAHKNSM	EGFL6	276	Q8IUX8
EQLLKQKMDELHKKL	BUB1	286	O43683
LHAKKMKLTKNGTVE	CSRNP2	131	Q9H175
MEGQKHLNSKKKGLK	A2ML1	501	A8K2U0
KNLHAKIIEKDAMIK	AMOTL1	756	Q8IY63
MEKISKLNIHSIIKK	DNMBP	986	Q6XZF7
ASMHKKEKSVLQGKL	ATP2B2	376	Q01814
MHLLKKTLQKCEKNG	HP1BP3	381	Q5SSJ5
KLLKHKEKGAIRLLM	RANBP1	76	P43487
GKKEINIIELSHKKM	PDZRN4	981	Q6ZMN7
LDKVLSDMKRHKKLE	PAGR1	201	Q9BTK6
KQLKSKLSHIKKMVG	OCLN	501	Q16625
LINHTKKLMEKEEKL	ITPR2	1656	Q14571
KTNNHIMKLTKGLIK	SERPIND1	261	P05546
LIKMHEKVGSQLKLK	MORC1	376	Q86VD1
SGKKEKMKVNKISLH	ANKRD31	466	Q8N7Z5
NGEKLKKSLFMLKEL	NOS2	601	P35228
AKDMHLVKKLAALLK	RAB3GAP2	551	Q9H2M9
SKLHKLKSEGFMKVL	KIDINS220	731	Q9ULH0
LSKIKHMLLKKEESL	GOLGA1	181	Q92805
IKLAEGLKNLKKMCL	NLRC4	781	Q9NPP4
GHKKMTTLQLKEELL	MBTD1	586	Q05BQ5
LLKTNKKLAKMIGHI	NAB1	221	Q13506
LKRIHGSFTLKEKMK	KIAA1109	2801	Q2LD37
LARKKGKSLHKDMAI	MCM3AP	486	O60318
IKYLTIMKLKNDKHL	CCDC178	481	Q5BJE1
KKQKMDKLLGELHTL	PCM1	406	Q15154
HLQLLMDKAKVKLQK	KIF6	666	Q6ZMV9
LLTELKTKLHEEKMK	JAKMIP3	71	Q5VZ66
MHRFEQLKKEKLKSL	GLI2	726	P10070
LLHGTKKKKEKMVSA	MCM3	551	P25205
LKEGMKIEATHVKKK	PAPOLG	476	Q9BWT3
EILNKAIHMKKSLEK	ATR	2196	Q13535
QESPMDLLKKKKHIR	CCDC175	761	P0C221
KKMKVKNGETLFELH	FAM111A	316	Q96PZ2
MNILNKVLSKHKDLK	CAPNS2	101	Q96L46
MLSSIKLKDKKHISI	DNAI7	536	Q6TDU7
DHAKMGIKEVKNRLK	DENND1A	436	Q8TEH3
SKHQEKLLKLIELGM	ERAP2	831	Q6P179
MEIKGEQISKLKKHQ	CEP57L1	371	Q8IYX8
KKIGKSILGKVHLAM	EEF2K	516	O00418
LMHPEDKDLKGKKAL	CCDC168	4351	Q8NDH2
EKLKGIHIMKKLKIL	DNAL1	106	Q4LDG9
KLLLLQKMLKNLKEG	CHD4	1051	Q14839
QMLKKHKEKFKTGLI	DNAH2	1136	Q9P225
KLQLMKKHQSDLKKL	CD34	256	P28906
KHLSENIKDKLKEMG	DYNLT2B	71	Q8WW35
VKDAMKKLLGKITLH	OR2K2	296	Q8NGT1
GKMVVLDKLLAKLKE	SMARCA1	486	P28370
KLKTLEVLLKDMEKG	SYNE1	3746	Q8NF91
LMVQVKKDLKTGHSK	TARDBP	131	Q13148
LLKKEMTLDLKTKFG	MIA3	266	Q5JRA6
KHKLLKEVDMVKVPL	SLC26A8	571	Q96RN1
DKQMDKKISILKDHG	SETD4	311	Q9NVD3
LKAGKKVKLSHEEVM	RMND1	336	Q9NWS8
KLKAEMDEHRLKLQK	TAOK3	481	Q9H2K8
GLREVTKHMKLNKIK	SECISBP2L	721	Q93073
LKEEVATLKKMLHQK	FAM76A	221	Q8TAV0
PMRKIDGLLNEHKKK	PRR12	1881	Q9ULL5
KGEKKLLHFIQLVIM	SSUH2	241	Q9Y2M2
KKLSKSEMHRGKKNE	CCDC110	341	Q8TBZ0
KSAMRKGHNLLKKKE	CEP164	1176	Q9UPV0
LEKAMHKCILKPLKG	RIN2	591	Q8WYP3
KAKLEKSLEHLRKQM	TRIM11	136	Q96F44
AKLMKLKGHTDNVKA	WDR48	201	Q8TAF3
RIKQKMKELASLHDK	STX16	91	O14662
ISKSELHKFKIKIMG	SEPTIN8	191	Q92599
MKLLKELHKESKTRD	PRKDC	3256	P78527
KMKLNKARKDHLIGP	ZC3H7A	941	Q8IWR0
GKKHRKQETKLKLMA	ZNF346	206	Q9UL40
KMTHKKLKISNDGLQ	MID2	541	Q9UJV3
EATGMFKKLTHLKKI	SLIT1	556	O75093
MKFHKKVGKLGVLDK	SETBP1	646	Q9Y6X0
SKLKKHRILLMKDES	ZFC3H1	831	O60293
VGKVHAKKLKQLMEE	ZMAT1	141	Q5H9K5
MARILKELKQKHPDK	SLC8A1	326	P32418
LGLLNKAKAHIKKLE	MXI1	106	P50539