Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	5.06e-08	473	33	9	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	9.96e-08	512	33	9	GO:0019787
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 TRIM64C TRIM73 MKRN2	1.24e-07	372	33	8	GO:0061630
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	1.38e-07	532	33	9	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 TRIM64C TRIM73 MKRN2	2.08e-07	398	33	8	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	RNF34 TRIM64B TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	3.18e-06	775	33	9	GO:0016746
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	RNF34 FERMT2 ACAP2 VPS13B	3.12e-04	199	33	4	GO:1901981
GeneOntologyMolecularFunction	zinc ion binding	TRIM64B ZFAND1 PAPPA TRIM64 TRIM50 TRIM64C TRIM73	5.31e-04	891	33	7	GO:0008270
GeneOntologyMolecularFunction	phosphatidylinositol binding	RNF34 FERMT2 ACAP2 VPS13B	1.75e-03	316	33	4	GO:0035091
GeneOntologyMolecularFunction	transition metal ion binding	TRIM64B ZFAND1 PAPPA TRIM64 TRIM50 TRIM64C TRIM73	2.84e-03	1189	33	7	GO:0046914
GeneOntologyBiologicalProcess	protein ubiquitination	RNF34 TRIM64B KLHL24 TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	2.45e-07	811	32	10	GO:0016567
GeneOntologyBiologicalProcess	post-translational protein modification	RNF34 TRIM64B KLHL24 TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C PARP16 TRIM73 MKRN2	3.40e-07	1074	32	11	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	RNF34 TRIM64B KLHL24 TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	5.95e-07	893	32	10	GO:0032446
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	RNF34 TRIM64B KLHL24 TRIM64 TRIM50 HUWE1 BIRC6 TRIM64C TRIM73 MKRN2	1.81e-06	1009	32	10	GO:0070647
GeneOntologyBiologicalProcess	microtubule depolymerization	MAP1S ARHGEF1 KIF2C	1.45e-04	66	32	3	GO:0007019
GeneOntologyCellularComponent	aggresome	EEF2 TRIM50 TRIM73	3.40e-05	40	33	3	GO:0016235
GeneOntologyCellularComponent	inclusion body	EEF2 TRIM50 TRIM73	3.83e-04	90	33	3	GO:0016234
MousePheno	hypochlorhydria	TRIM50 TRIM73	4.49e-05	7	21	2	MP:0008001
Domain	BBOX	TRIM64B TRIM64 TRIM50 TRIM73	5.67e-06	69	32	4	SM00336
Domain	-	TRIM64B TRIM64 TRIM50 TRIM73	6.36e-06	71	32	4	4.10.45.10
Domain	zf-B_box	TRIM64B TRIM64 TRIM50 TRIM73	6.73e-06	72	32	4	PF00643
Domain	Znf_RING_CS	TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	7.92e-06	163	32	5	IPR017907
Domain	ZF_RING_1	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	8.76e-06	291	32	6	PS00518
Domain	-	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 ZNF423 MKRN2	8.86e-06	449	32	7	3.30.40.10
Domain	ZF_RING_2	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	1.00e-05	298	32	6	PS50089
Domain	Znf_RING/FYVE/PHD	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 ZNF423 MKRN2	1.02e-05	459	32	7	IPR013083
Domain	ZF_BBOX	TRIM64B TRIM64 TRIM50 TRIM73	1.02e-05	80	32	4	PS50119
Domain	Znf_C3HC4_RING-type	TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	1.03e-05	172	32	5	IPR018957
Domain	Znf_B-box	TRIM64B TRIM64 TRIM50 TRIM73	1.08e-05	81	32	4	IPR000315
Domain	RING	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	1.14e-05	305	32	6	SM00184
Domain	Znf_RING	RNF34 TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	1.67e-05	326	32	6	IPR001841
Domain	zf-C3HC4	TRIM64B TRIM64 TRIM50 TRIM73 MKRN2	3.59e-05	223	32	5	PF00097
Domain	Butyrophylin	TRIM64B TRIM64 TRIM50	2.31e-04	70	32	3	IPR003879
Domain	SPRY	TRIM64B TRIM64 TRIM50	4.39e-04	87	32	3	SM00449
Domain	ConA-like_dom	TRIM64B PAPPA TRIM64 TRIM50	5.11e-04	219	32	4	IPR013320
Domain	SPRY	TRIM64B TRIM64 TRIM50	5.51e-04	94	32	3	PF00622
Domain	SPRY_dom	TRIM64B TRIM64 TRIM50	5.51e-04	94	32	3	IPR003877
Domain	B30.2/SPRY	TRIM64B TRIM64 TRIM50	5.68e-04	95	32	3	IPR001870
Domain	B302_SPRY	TRIM64B TRIM64 TRIM50	5.68e-04	95	32	3	PS50188
Domain	ArfGap	ACAP2 ACAP3	1.12e-03	29	32	2	SM00105
Domain	ARFGAP	ACAP2 ACAP3	1.12e-03	29	32	2	PS50115
Domain	ArfGAP	ACAP2 ACAP3	1.12e-03	29	32	2	IPR001164
Domain	ArfGap	ACAP2 ACAP3	1.12e-03	29	32	2	PF01412
Domain	-	ACAP2 ACAP3	1.20e-03	30	32	2	1.20.1270.60
Domain	AH/BAR-dom	ACAP2 ACAP3	1.20e-03	30	32	2	IPR027267
Domain	PH	FERMT2 ACAP2 ARHGEF1 ACAP3	1.24e-03	278	32	4	SM00233
Domain	PH_DOMAIN	FERMT2 ACAP2 ARHGEF1 ACAP3	1.26e-03	279	32	4	PS50003
Domain	PH_domain	FERMT2 ACAP2 ARHGEF1 ACAP3	1.28e-03	280	32	4	IPR001849
Domain	Znf-RING_LisH	TRIM50 TRIM73	1.54e-03	34	32	2	IPR027370
Domain	zf-RING_UBOX	TRIM50 TRIM73	1.54e-03	34	32	2	PF13445
Domain	-	FERMT2 ACAP2 ARHGEF1 ACAP3	4.28e-03	391	32	4	2.30.29.30
Domain	PH_dom-like	FERMT2 ACAP2 ARHGEF1 ACAP3	5.79e-03	426	32	4	IPR011993
Domain	PH	FERMT2 ACAP2 ACAP3	6.94e-03	229	32	3	PF00169
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	RNF34 TUBB6 TRIM50 HUWE1 JAML TRIM73 KIF2C	1.04e-04	719	23	7	MM14540
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM64B TRIM64 TRIM64C	3.85e-07	15	34	3	19703589
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM50 TRIM73	2.78e-06	3	34	2	26196062
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM50 TRIM73	2.78e-06	3	34	2	22872646
Pubmed	ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.	ACAP2 ACAP3	5.56e-06	4	34	2	27330119
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM50 TRIM73	9.26e-06	5	34	2	20049703
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM50 TRIM73	9.26e-06	5	34	2	18398435
Pubmed	TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.	TRIM50 TRIM73	1.39e-05	6	34	2	36178239
Pubmed	TRIM50 regulates Beclin 1 proautophagic activity.	TRIM50 TRIM73	1.39e-05	6	34	2	29604308
Pubmed	Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.	TRIM50 TRIM73	1.94e-05	7	34	2	26025256
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	TUBB6 EEF2 HUWE1 FERMT2	2.08e-05	166	34	4	35687106
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM64B TRIM64 TRIM64C	2.16e-05	55	34	3	19468303
Pubmed	Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1.	RNF34 LRP1B	3.33e-05	9	34	2	35170427
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	PAPPA EEF2 HUWE1	4.28e-05	69	34	3	32238831
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	TRIM64B TRIM64 TRIM64C	6.66e-05	80	34	3	16554811
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	EEF2 HUWE1	7.19e-05	13	34	2	29285303
Pubmed	The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.	TRIM50 TRIM73	1.10e-04	16	34	2	22792322
Pubmed	RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.	HUWE1 MKRN2	1.25e-04	17	34	2	37080995
Pubmed	Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.	WNK2 KIF2C	1.57e-04	19	34	2	9070936
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM64B TRIM64	1.57e-04	19	34	2	22144910
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TUBB6 EEF2 HUWE1 FERMT2 BIRC6 ARHGEF1 KIF2C	2.84e-04	1353	34	7	29467282
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	TUBB6 EEF2 HUWE1 KIF2C	3.02e-04	332	34	4	32786267
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	HUWE1 ARHGEF1 MKRN2	3.71e-04	143	34	3	30397336
Pubmed	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	TUBB6 EEF2 HUWE1	3.86e-04	145	34	3	23349634
Pubmed	The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.	TUBB6 EEF2	3.97e-04	30	34	2	36732658
Pubmed	TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.	TUBB6 EEF2	3.97e-04	30	34	2	34285210
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	TUBB6 EEF2 HUWE1 MAP1S FERMT2 BIRC6 ARHGEF1	4.40e-04	1455	34	7	22863883
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	WNK2 KIF2C	5.10e-04	34	34	2	7490078
Pubmed	Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.	EEF2 ARHGEF1	6.05e-04	37	34	2	9798653
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PALD1 HUWE1 MAP1S BIRC6 ZNF614 WNK2	6.37e-04	1105	34	6	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PALD1 VPS13B ZNF423 DOP1B	6.49e-04	407	34	4	12693553
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	HUWE1 MAP1S FERMT2 BIRC6 LRP1B WNK2	7.46e-04	1139	34	6	36417873
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	TUBB6 EEF2 ARHGEF1	8.10e-04	187	34	3	26460568
Pubmed	Defining the membrane proteome of NK cells.	EEF2 HUWE1 ACAP2 BIRC6 PARP16 KIF2C	8.50e-04	1168	34	6	19946888
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TUBB6 MAP1S BIRC6 KIF2C	9.12e-04	446	34	4	24255178
Pubmed	Agrin has a pathological role in the progression of oral cancer.	EEF2 MAP1S ACAP2	9.41e-04	197	34	3	29872149
Cytoband	11q14.3	TRIM64B TRIM64	2.60e-04	32	34	2	11q14.3
GeneFamily	Ring finger proteins	RNF34 TRIM64B TRIM64 TRIM50 TRIM64C TRIM73 MKRN2	4.84e-08	275	24	7	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM64B TRIM64 TRIM50 TRIM64C TRIM73	1.41e-07	95	24	5	59
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ACAP2 ACAP3	2.27e-04	17	24	2	1291
GeneFamily	ArfGAPs	ACAP2 ACAP3	8.70e-04	33	24	2	395
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FERMT2 ACAP2 ACAP3	2.47e-03	206	24	3	682
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	HUWE1 BIRC6 TRIM73 DOP1B	1.17e-05	185	34	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	HUWE1 BIRC6 TRIM73 DOP1B	1.19e-05	186	34	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HUWE1 BIRC6 TRIM73 DOP1B	1.32e-05	191	34	4	9454f642c3621370fa23640b631301346b300950
Disease	presubiculum volume	ZNF423 WNK2	4.87e-04	31	31	2	EFO_0009400
Disease	cerebellar volume measurement	PAPPA DENND3	1.37e-03	52	31	2	EFO_0020864
Disease	hippocampal atrophy	PGM2L1 VPS13B	1.59e-03	56	31	2	EFO_0005039
Disease	brain measurement, neuroimaging measurement	PAPPA DENND3 ARHGEF1 WNK2	2.52e-03	550	31	4	EFO_0004346, EFO_0004464
Disease	stomach cancer (is_implicated_in)	EEF2 LRP1B	2.61e-03	72	31	2	DOID:10534 (is_implicated_in)
Disease	bipolar disorder	C15orf32 HUWE1 CMTR2 WNK2	2.99e-03	577	31	4	MONDO_0004985
Disease	hippocampal volume	PAPPA ZNF423 WNK2	3.68e-03	297	31	3	EFO_0005035
Disease	mean fractional anisotropy measurement	TRAPPC13 WNK2	4.49e-03	95	31	2	EFO_0008399
Disease	neuroimaging measurement	RNF34 PAPPA DENND3 ARHGEF1 WNK2	4.80e-03	1069	31	5	EFO_0004346
Disease	cortical thickness	PALD1 KLHL24 DENND3 ZNF423 WNK2	5.68e-03	1113	31	5	EFO_0004840
Disease	lower face morphology measurement	LRP1B VPS13B	5.86e-03	109	31	2	EFO_0010948
Disease	3-hydroxypropylmercapturic acid measurement	PAPPA ACAP2 LRP1B	5.91e-03	352	31	3	EFO_0007014
Disease	pneumonia, COVID-19	LRP1B VPS13B	6.29e-03	113	31	2	EFO_0003106, MONDO_0100096
Disease	Papillary Renal Cell Carcinoma	EEF2 LRP1B	8.00e-03	128	31	2	C1306837
Disease	Renal Cell Carcinoma	EEF2 LRP1B	8.00e-03	128	31	2	C0007134
Disease	mood instability measurement	CMTR2 LRP1B	8.00e-03	128	31	2	EFO_0008475
Disease	Sarcomatoid Renal Cell Carcinoma	EEF2 LRP1B	8.00e-03	128	31	2	C1266043
Disease	Chromophobe Renal Cell Carcinoma	EEF2 LRP1B	8.00e-03	128	31	2	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	EEF2 LRP1B	8.00e-03	128	31	2	C1266044
Disease	body weight	PAPPA KLHL24 HUWE1 LRP1B ZNF423	9.52e-03	1261	31	5	EFO_0004338

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKVELAAECCREILH	ARHGEF1	586	Q92888
QCLRLCPFLEDHKED	BIRC6	1166	Q9NR09
VIPDSFLKRHEECCV	CMTR2	351	Q8IYT2
KPCEDIERRFCFEVL	ACAP3	321	Q96P50
EDLRLCTVKHCEDIE	ACAP2	311	Q15057
VCVATEPKEDCVHFL	DENND3	51	A2RUS2
EVCEICRLQVLHPFD	MKRN2	191	Q9H000
RECVIFCVREEPVLF	PALD1	156	Q9ULE6
EEVEIKCPLNHIACL	LRP1B	71	Q9NZR2
DLCLVSPCEFEHRKA	MAP1S	736	Q66K74
ICEDIICHALLDPDK	DOP1B	911	Q9Y3R5
SPHDKEILKCIEECV	PGM2L1	196	Q6PCE3
VHFACEKTDCPELAV	PAPPA	1206	Q13219
EHEVDLCRKECPFVI	HUWE1	461	Q7Z6Z7
CVAVCEVIDHPDVKC	PARP16	211	Q8N5Y8
TDVIICVEGKEFPCH	KLHL24	66	Q6TFL4
ICLKDLEEDHACIPI	EEF2	556	P13639
FICTEVDCKVVHEFI	FERMT2	636	Q96AC1
TDPIEEHRICVCVRK	KIF2C	251	Q99661
EIKEKPCHFERCEGE	JAML	321	Q86YT9
HILDPKQIFCVADVC	C15orf32	126	Q32M92
VLDVVRKECEHCDCL	TUBB6	116	Q9BUF5
TCREKEDLVDLVLCH	RNF34	136	Q969K3
CPEVEELVFSHFVIC	VPS13B	2621	Q7Z7G8
EDRLQCPICLEVFKE	TRIM73	11	Q86UV7
FKDCAERELVAVICP	ZFAND1	66	Q8TCF1
EKADLQCIHCPEVFV	ZNF423	291	Q2M1K9
VHDPEIKEIIGECIC	WNK2	421	Q9Y3S1
IEKPHACIECEQTFL	ZNF614	201	Q8N883
ICVLHEETKELFCEA	TRIM64C	91	A6NLI5
ICVLHEETKELFCEA	TRIM64	91	A6NGJ6
ELKPDCCIDDVIHHE	TRAPPC13	121	A5PLN9
EDRLQCPICLEVFKE	TRIM50	11	Q86XT4
ICVLHEETKELFCEA	TRIM64B	91	A6NI03