Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PRRC2C STARD9 ZBTB21 IQSEC1 NAV1 FAM83G KIAA1191 RAPGEF2 PC DDX41 ENKD1 AHNAK2 NUAK2	7.29e-07	861	96	13	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B PRRC2C STARD9 NAV1 PPIP5K1 MICAL3 MED13L SPEN PLXNA2	1.99e-06	407	96	9	12693553
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B CCNT1 YLPM1 GREB1 RBM28 DDX41 SPEN NOP2	4.93e-06	341	96	8	32971831
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SFMBT1 PHF2 ORC1 ZBTB39 SUPT6H RRP9 YLPM1 RBM28 CMAS PC DDX41 SPEN NOP2 RPL6	1.26e-05	1294	96	14	30804502
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PHF2 PDS5B CCNT1 WWOX PRRC2C YLPM1 RBM28 PC SSX1 DDX41 SPEN NOP2	1.28e-05	954	96	12	36373674
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ORC1 SUPT6H RRP9 YLPM1 ABCD3 PWWP3A RBM28 CMAS PC DDX41 NOP2 RPL6	1.82e-05	989	96	12	36424410
Pubmed	Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.	PC SLC1A2	2.26e-05	3	96	2	38086219
Pubmed	Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.	VCAN SCNN1B GREB1 ADAM12	4.11e-05	69	96	4	21491542
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PHF2 PDS5B LIPA SUPT6H VCAN YLPM1 ABCD3 IQSEC1 CMAS DDX41 SPEN RPL6	4.37e-05	1082	96	12	38697112
Pubmed	Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.	SFMBT1 WWOX	4.51e-05	4	96	2	22479346
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PCNX2 STARD9 PRICKLE2 IQSEC1 KLHDC10 PLEKHM1	4.75e-05	233	96	6	37704626
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PHF2 PDS5B CCNT1 SETDB2 ZBTB21 CMAS DDX41 SPEN NOP2	4.83e-05	608	96	9	36089195
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PHF2 PDS5B CCNT1 ZBTB39 CEBPE PRRC2C ZBTB21 RBM28 MED13L DDX41 SPEN NOP2	5.26e-05	1103	96	12	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 ORC1 GDPD5 NAV1 MICAL3 JADE1 MED13L PC SPEN PLEKHM1 AHNAK2 BAHCC1	5.35e-05	1105	96	12	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PHF2 CCNT1 SETDB2 LTN1 ZBTB21 IQSEC1 RAPGEF2 CMAS DDX41 ZC3H3 ENKD1 BAHCC1	5.88e-05	1116	96	12	31753913
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SUPT6H STARD9 NAV1 RBM28 KIAA1191 NOP2 RPL6	6.61e-05	361	96	7	30344098
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	RRP9 YLPM1 ZBTB21 IQSEC1 RBM28 DDX41 NOP2	6.97e-05	364	96	7	24778252
Pubmed	Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.	RORC IL22RA1	7.50e-05	5	96	2	35845169
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDS5B SUPT6H PRRC2C RRP9 YLPM1 RBM28 SPEN NOP2 RPL6	8.33e-05	653	96	9	22586326
Pubmed	Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.	TICAM1 VCAN	1.12e-04	6	96	2	28912382
Pubmed	The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.	LTN1 RPL6	1.12e-04	6	96	2	25877867
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PDS5B SUPT6H RRP9 YLPM1 ZBTB21 ABCD3 RBM28 DDX41 SPEN NOP2 RPL6	1.23e-04	1024	96	11	24711643
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	GGNBP2 MED13L RAPGEF2	1.25e-04	35	96	3	26091241
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PRRC2C VCAN ABCD3 PRICKLE2 IQSEC1 NAV1 MICAL3 RAPGEF2 CMAS PC SLC1A2 RPL6 NUAK2	1.55e-04	1431	96	13	37142655
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	SUPT6H AHNAK2	1.57e-04	7	96	2	23415230
Pubmed	Chronic UV radiation-induced RORγt+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion.	TICAM1 RORC	1.57e-04	7	96	2	34504008
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PDS5B GGNBP2 GHRL ABI3BP PRRC2C STARD9 CTAGE1 YLPM1 ZBTB21 SPEN RPL6 PLXNA2 BAHCC1	1.67e-04	1442	96	13	35575683
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	STARD9 VCAN ABCD3 PRICKLE2 IQSEC1 RAPGEF2 PC	1.95e-04	430	96	7	32581705
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZBTB39 PPIP5K1 RAPGEF2 PLEKHM1	2.03e-04	104	96	4	9205841
Pubmed	Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.	SUPT6H DAZL	2.09e-04	8	96	2	33749946
Pubmed	Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes.	TICAM1 RORC	2.09e-04	8	96	2	24367096
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CCNT1 WWOX PRRC2C YLPM1 ZBTB21 ABCD3 PC NOP2 RPL6 AHNAK2	2.61e-04	934	96	10	33916271
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SUPT6H PRRC2C YLPM1 RBM28 DDX41 SPEN NOP2 RPL6	2.77e-04	605	96	8	28977666
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	LIPA PRRC2C NAV1 NOP2 UST AHNAK2	3.26e-04	332	96	6	37433992
Pubmed	A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells.	TICAM1 RORC	3.34e-04	10	96	2	23334414
Pubmed	The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development.	VCAN PLXNA2	3.34e-04	10	96	2	22300732
Pubmed	The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.	CDYL2 DAZL	3.34e-04	10	96	2	12837688
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ORC1 PDS5B CCNT1 LTN1 ABCD3 IQSEC1 RBM28 CMAS DDX41 NOP2 RPL6 AHNAK2	3.51e-04	1353	96	12	29467282
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WWOX YLPM1 IQSEC1 RAPGEF2 RPL6	3.71e-04	220	96	5	24550385
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PDS5B CCNT1 SUPT6H ZBTB21 IQSEC1	3.86e-04	222	96	5	37071664
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	PRRC2C RRP9 RBM28 CMAS DDX41 NOP2 RPL6	3.93e-04	483	96	7	36912080
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SUPT6H PRRC2C RRP9 YLPM1 ZNF385A RBM28 DDX41 SPEN NOP2	4.00e-04	807	96	9	22681889
Pubmed	Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations.	TICAM1 RORC	4.08e-04	11	96	2	33113356
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	PRRC2C YLPM1 ABCD3 RBM28 PC DDX41 NOP2 RPL6	4.70e-04	655	96	8	35819319
Pubmed	ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.	IGFBP2 FGF5 PLXNA2	5.92e-04	59	96	3	31924792
Pubmed	GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development.	GHRL ONECUT1	6.71e-04	14	96	2	15548585
Pubmed	The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells.	GHRL ONECUT1	6.71e-04	14	96	2	27270601
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SUPT6H VCAN ABCD3 SPEN RPL6	6.74e-04	251	96	5	28077445
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	PHF2 ZBTB39 CEBPE RORC JADE1 SSX1 SPEN ZNF714 FOXJ1	7.25e-04	877	96	9	20211142
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	HMCN1 PRRC2C YLPM1 DDX41	7.53e-04	147	96	4	28977470
Pubmed	Nucleosome-interacting proteins regulated by DNA and histone methylation.	ORC1 ZBTB21	7.73e-04	15	96	2	21029866
Pubmed	Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.	FGF5 DAZL	7.73e-04	15	96	2	29320730
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCNX2 PHF2 WWOX SUPT6H NAV1 CDYL2 MICAL3 GREB1 ZNF385A RAPGEF2 KCNIP2 PLEKHM1	8.17e-04	1489	96	12	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PHF2 ORC1 CCNT1 GGNBP2 SUPT6H RRP9 LTN1 ABCD3 CDYL2 ZNF385A CMAS SPEN	8.56e-04	1497	96	12	31527615
Pubmed	A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.	FMN1 STARD9	8.82e-04	16	96	2	7633422
Pubmed	Novel pancreas organogenesis markers refine the pancreatic differentiation roadmap of embryonic stem cells.	GHRL LTN1	8.82e-04	16	96	2	24390927
Pubmed	Identification of the human testis protein phosphatase 1 interactome.	STARD9 YLPM1 ENKD1	8.97e-04	68	96	3	21382349
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PHF2 PDS5B SUPT6H MED13L NOP2	9.66e-04	272	96	5	31010829
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	ABCD3 RBM28 PC NOP2 RPL6	9.66e-04	272	96	5	25315684
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	MMP27 ZNF112 MED13L	1.02e-03	71	96	3	33541421
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PHF2 PDS5B CCNT1 RRP9 ABCD3 IQSEC1 RBM28 PC DDX41 NOP2 RPL6	1.03e-03	1318	96	11	30463901
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	PRRC2C YLPM1 NOP2 RPL6	1.08e-03	162	96	4	31363146
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SFMBT1 WWOX ZBTB21 ABCD3 NAV1 PC	1.08e-03	418	96	6	34709266
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	PHF2 SPEN	1.12e-03	18	96	2	25363768
Pubmed	The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.	GHRL ONECUT1	1.12e-03	18	96	2	22434868
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	HMCN1 ABI3BP VCAN COLQ	1.21e-03	167	96	4	22159717
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	TICAM1 SLC1A2	1.25e-03	19	96	2	22561518
Pubmed	Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.	MMP27 ADAM12	1.25e-03	19	96	2	15063736
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PDS5B YLPM1 ZBTB21 IQSEC1 MICAL3 DDX41 SPEN NOP2	1.38e-03	774	96	8	15302935
Pubmed	The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.	GHRL SLC1A2	1.39e-03	20	96	2	20413507
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PRRC2C YLPM1 ZBTB21 IQSEC1 NAV1 ARMCX4 RAPGEF2 NOP2 SLC1A2	1.39e-03	963	96	9	28671696
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SUPT6H RRP9 YLPM1 ABCD3 RBM28 NOP2	1.41e-03	440	96	6	34244565
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SFMBT1 ABCD3 PWWP3A RAPGEF2 PC SPEN NOP2 RPL6	1.41e-03	777	96	8	35844135
Pubmed	The sequence of the human genome.	CTAGE1 SCNN1B WEE2 MICAL3 RBM28 ARMCX4 FER1L5	1.43e-03	603	96	7	11181995
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	FGF5 MED13L	1.53e-03	21	96	2	25249183
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	CCNT1 YLPM1 IQSEC1 PC	1.66e-03	182	96	4	32239614
Pubmed	Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.	GHRL ONECUT1	1.68e-03	22	96	2	17400205
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	SFMBT1 SUPT6H SPEN RPL6	1.69e-03	183	96	4	36129980
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PHF2 PDS5B GGNBP2 ZBTB21 JADE1 ZNF385A ONECUT1 PLXNA2	1.80e-03	808	96	8	20412781
Pubmed	Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.	GHRL ONECUT1	1.84e-03	23	96	2	19805515
Pubmed	GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.	VCAN PLXNA2	1.84e-03	23	96	2	29567669
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PHF2 PDS5B SUPT6H STARD9 RRP9 ABCD3 PC DDX41 SPEN NOP2 RPL6	1.91e-03	1425	96	11	30948266
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	IGFBP2 ZNF391 VCAN LTN1 FAM83G MICAL3 KIAA1191 RAPGEF2 PC ZNF714	1.94e-03	1215	96	10	15146197
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	SUPT6H PRRC2C MMP27 ZNF385A DDX41 NOP2 RPL6	1.99e-03	639	96	7	23443559
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	PRRC2C RRP9 YLPM1 RBM28 PC NOP2 RPL6	2.02e-03	641	96	7	36057605
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PHF2 NAV1 MICAL3 MED13L CMAS SPEN NOP2	2.10e-03	645	96	7	25281560
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	PDS5B CCNT1 SPEN NOP2	2.13e-03	195	96	4	19454010
Pubmed	The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.	GHRL ONECUT1	2.17e-03	25	96	2	21786021
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	WWOX PRRC2C PC NOP2 RPL6	2.25e-03	330	96	5	32529326
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	PRRC2C ABCD3 PC DDX41 NOP2 RPL6	2.32e-03	486	96	6	30940648
Pubmed	Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.	IGFBP2 FOXJ1	2.35e-03	26	96	2	27861515
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PRRC2C RRP9 ABCD3 NAV1 RBM28 CMAS DDX41 SPEN NOP2 RPL6	2.48e-03	1257	96	10	36526897
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PHF2 ZBTB39 LTN1 MICAL3 KIAA1191 KLHDC10	2.49e-03	493	96	6	15368895
Pubmed	Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.	PRRC2C SLC1A2	2.53e-03	27	96	2	34709416
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ORC1 ABCD3 SPEN RPL6	2.69e-03	208	96	4	33230847
Cytoband	11q13.4-q13.5	GDPD5 PC	4.33e-06	2	96	2	11q13.4-q13.5
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRABD2A LIPG NAV1 CDYL2 ADAM12 NUAK2	1.80e-06	169	96	6	44d201361eb497222a4972a0e10bac1e05dcfd0a
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PCNX2 ABI3BP VCAN PRICKLE2 NAV1 UST	4.11e-06	195	96	6	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	WWOX FMN1 PRICKLE2 MED13L RAPGEF2 UST	4.49e-06	198	96	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF2 WWOX LIPG PWWP3A ENKD1	9.94e-06	132	96	5	4152529611eeacf0c547e2a134d5b98c45426b13
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	GHRL C16orf86 C7orf57 SBK2 FOXJ1	1.57e-05	145	96	5	ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GDPD5 STARD9 NAV1 CDYL2 NUAK2	1.79e-05	149	96	5	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GDPD5 STARD9 NAV1 CDYL2 NUAK2	1.84e-05	150	96	5	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABI3BP ZNF385A KCNIP2 ADAM12 ZC3H3	2.52e-05	160	96	5	778faada072e3abfa76a9a06fd4885fb63de7902
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CCNT1 LIPG C16orf86 PPIP5K1 PC	3.36e-05	170	96	5	c1f7f1bb8865e954bb499963d82bb51923d5d8d6
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRICKLE2 SCNN1B SERPINA10 ARMCX4 PLEKHM1	3.97e-05	176	96	5	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	TRIM2 IGFBP2 HMCN1 IMPG1 SCNN1B	3.97e-05	176	96	5	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	10x5'-Lung-Myeloid_Dendritic-migDC\|Lung / Manually curated celltypes from each tissue	IDO2 NAV1 MED13L ADAM12 NUAK2	4.41e-05	180	96	5	e9e8992deb0beeee5548910e4616e7c990763d99
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 ADAM12 NUAK2	4.53e-05	181	96	5	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	GDPD5 PPIP5K1 KCNIP2 PC ADAM12	4.77e-05	183	96	5	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCN2 HMCN1 FMN1 PLA2G3 ZNF112	4.77e-05	183	96	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IDO2 TRABD2A NAV1 CDYL2 ADAM12	5.03e-05	185	96	5	7e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRRC2C VCAN C18orf63 NAV1 MED13L	5.16e-05	186	96	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Control-Myeloid-DC_Mature\|Myeloid / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 ADAM12 NUAK2	5.16e-05	186	96	5	e9e58c5871b4966cd3586b611703e21af8df6360
ToppCell	Control-Myeloid-DC_Mature\|Control / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 ADAM12 NUAK2	5.29e-05	187	96	5	049780ca2a3e6adcd89dc2cf3095b5ad068b244a
ToppCell	Control-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 CDYL2 ADAM12	5.29e-05	187	96	5	51bfc450e78284796b02317e91830357850b5437
ToppCell	COPD-Myeloid-DC_Mature\|COPD / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 ADAM12 NUAK2	5.43e-05	188	96	5	de93ccb53edb8599da9e312db0e3af604c21f673
ToppCell	(3)_DC_activated\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IDO2 TRABD2A NAV1 ADAM12 NUAK2	5.56e-05	189	96	5	e977838793fc0eb1499e81018e33e4ccb4a5f0c5
ToppCell	COPD-Myeloid-DC_Mature\|Myeloid / Disease state, Lineage and Cell class	IDO2 TRABD2A NAV1 ADAM12 NUAK2	5.99e-05	192	96	5	baebd462f464e7d0e462d07a74bb5d685a9fc3b6
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	WWOX ABI3BP VCAN NAV1 UST	6.30e-05	194	96	5	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	tumor_Lung-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	IDO2 TRABD2A NAV1 ADAM12 SLC1A2	6.45e-05	195	96	5	72a7c4beb880390b29f3c5d6dd9dbb082af50fe2
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	WWOX ABI3BP VCAN JADE1 UST	6.45e-05	195	96	5	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	HMCN1 ABI3BP VCAN PRICKLE2 ADAM12	6.77e-05	197	96	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	HMCN1 ABI3BP VCAN PRICKLE2 ADAM12	6.77e-05	197	96	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	Control-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	PCNX2 ABI3BP VCAN NAV1 GREB1	6.77e-05	197	96	5	64cc5f61c88e9560b0f8f6f3151255dffb5c3d66
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	VCAN NAV1 JADE1 MED13L NUAK2	7.10e-05	199	96	5	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HMCN1 ABI3BP STARD9 VCAN NAV1	7.27e-05	200	96	5	b4ccffdd79526c85e5273d27b668dbddcddba1ee
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; PC3; HT_HG-U133A	PHF2 GDPD5 TRIM2 SUPT6H YLPM1 FGF5 MICAL3 PC	1.47e-06	199	92	8	6308_DN
Drug	Daff	WWOX PWWP3A PLEKHM1	2.21e-06	7	92	3	CID000085990
Drug	Alverine citrate salt [5560-59-8]; Down 200; 8.4uM; PC3; HT_HG-U133A	VCAN RAPGEF2 KLHDC10 CMAS ZC3H3 UST PLXNA2	1.35e-05	193	92	7	6345_DN
Drug	Isopropamide iodide [71-81-8]; Down 200; 8.4uM; HL60; HT_HG-U133A	ZBTB39 SUPT6H TICAM1 IQSEC1 SNAPC2 SSX1 BAHCC1	1.54e-05	197	92	7	2720_DN
Disease	Salivary Gland Neoplasms	IGFBP2 VCAN SPEN	4.31e-04	47	92	3	C0036095
Disease	Age-related macular degeneration	HMCN1 RAX2	1.42e-03	18	92	2	cv:C0242383
Disease	Cannabis use initiation	WWOX UST	1.42e-03	18	92	2	EFO_0007586
Disease	Endometrioma	ABI3BP VCAN GREB1 UST	1.64e-03	161	92	4	C0269102
Disease	Endometriosis	ABI3BP VCAN GREB1 UST	1.64e-03	161	92	4	C0014175
Disease	cortical thickness	PDS5B WWOX VCAN YLPM1 NAV1 MICAL3 CMAS ADAM12 PLXNA2 PLEKHM1	2.46e-03	1113	92	10	EFO_0004840
Disease	Dwarfism	ORC1 IQSEC1	2.75e-03	25	92	2	C0013336
Disease	coronary artery calcification	ABI3BP STARD9 PRICKLE2 MICAL3 MED13L ONECUT1	2.88e-03	450	92	6	EFO_0004723
Disease	cortical surface area measurement	TRIM2 CLCN2 WWOX PRRC2C VCAN NAV1 MED13L PC ADAM12 PLXNA2 PLEKHM1	3.09e-03	1345	92	11	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKPNPLLSRHKKSRG	ZNF385A	291	Q96PM9
GLPRGAHKLLRAKKA	BAHCC1	2206	Q9P281
CKPRGQLSGHLLKPR	LINC01590	56	Q5TEZ4
PRHGPKRKPVKSLSL	C16orf86	101	Q6ZW13
LGPGASLKRKDPKDH	ENKD1	86	Q9H0I2
LHKVKVGKSPPVRGS	VCAN	21	P13611
DNPPKGALKKLIHAA	CTAGE1	276	Q96RT6
APSPAGPLHKGKKAV	CEBPE	186	Q15744
ARKRASPTGGIKKPH	H3Y2	26	P0DPK5
AHLGHLGKGLMRKPP	ADAM12	766	O43184
KTRVPHSKLDKGPTG	CCNT1	631	O60563
LPGAKNKVKGNPHTV	ARMCX4	601	Q5H9R4
LGPGEEAPKKKHRRN	RAX2	16	Q96IS3
LLGPSKGAPLAKRSK	RBM28	741	Q9NW13
LPVLHHKSKKGPPRQ	PDS5B	711	Q9NTI5
GPLNKRSTHGNKKPR	FMN1	146	Q68DA7
PQKKLNLSHKGIGEP	LRCOL1	26	A6NCL2
HNSSGLLSPLRKKPL	LTN1	576	O94822
PKSIHTLGFPGRVKK	MMP27	361	Q9H306
ALPSLDQKKRGGHKA	COLQ	36	Q9Y215
GLHLLKPLSIPKRLG	MICAL3	1376	Q7RTP6
SPKRSGKIPPKLHNH	MED13L	361	Q71F56
GILSNSGPPKKRHKG	GREB1	301	Q4ZG55
NLLGSPKIKKGLSPH	GGNBP2	446	Q9H3C7
KLPGFKKIHVLGFRP	IMPG1	276	Q17R60
EKLIVGKKPIGSLHP	IQSEC1	726	Q6DN90
AAAKAKHGKPNHLPG	IDO2	371	Q6ZQW0
GLVDKGPLKKLPHLS	PCNX2	246	A6NKB5
KSGKLKKIRADGPPH	PLXNA2	451	O75051
GKHHLGLEEPKKLRP	IGFBP2	206	P18065
VQLSGRPHLPGKKKI	KLHDC10	46	Q6PID8
EHGKDRGNTPKKPRL	ONECUT1	376	Q9UBC0
HPPGPTKKALKQRFL	KCNIP2	26	Q9NS61
GPEGRLEDKLHKPKA	LIPG	26	Q9Y5X9
KKDLGPKPALIGHRG	GDPD5	221	Q8WTR4
EGKKQPPRAHNLKPR	KIAA1191	281	Q96A73
AILRGLKKKGIHHPT	DDX41	191	Q9UJV9
RNPLGKLIKKGFGLH	HMCN1	261	Q96RW7
AHCKKSLLGRPFLPK	PRICKLE2	286	Q7Z3G6
PACKRHLLGRKPGAQ	ORC1	96	Q13415
GKAKRGCSPRVKPQH	FGF5	196	P12034
SKKPPAKLQPRALAG	GHRL	41	Q9UBU3
VKLAKQGGRPDLLKH	C7orf57	71	Q8NEG2
AIHPGNPKLKKQLGP	SLC1A2	141	P43004
GEGRLGHKRKQPLPK	FOXJ1	266	Q92949
SPKHLRPKGQLQKEP	IL22RA1	421	Q8N6P7
INFHGKKLKLGPAIR	DAZL	101	Q92904
HGPKRIICEGPKKKA	SCNN1B	36	P51168
HRQKGTPLALKQLPK	SBK2	81	P0C263
LGKSHGSLKLKRQPH	C18orf63	581	Q68DL7
KKPLGLKGPALAEHP	FAM83G	371	A6ND36
ELKKPISLGHPGSLK	NAV1	516	Q8NEY1
HKKGLRKSENPRGPL	PWWP3A	176	Q2TAK8
AGGKRKKSAHQKPLP	PLEKHM1	71	Q9Y4G2
FKGSHKSGKQLPPHL	PHF2	381	O75151
KSGKQLPPHLVQGAK	PHF2	386	O75151
KTPTVHGLGPKKERL	FER1L5	1646	A0AVI2
ARGGSKGIPLKNIKH	CMAS	51	Q8NFW8
KGIPLKNIKHLAGVP	CMAS	56	Q8NFW8
EHKPGPIGKERSLKN	PRRC2C	2111	Q9Y520
TKKSSHLPLGSPLKR	STARD9	1056	Q9P2P6
LKKPHKRDPLQNSPG	JADE1	591	Q6IE81
AHRPGKSNLKLPKGI	NUAK2	396	Q9H093
QKPPQASGLLLHRKG	NUAK2	486	Q9H093
KPKDHHQPLGRAKGV	NOP2	741	P46087
QHLRKGPPHQKGSKR	PLA2G3	306	Q9NZ20
GKQLHPPGKANISEK	SSX1	136	Q16384
RALGLHGKKSGKPPL	ABCD3	31	P28288
GASLKGHLPKVQRPS	AHNAK2	751	Q8IVF2
GTSHKRKRINPPLAK	CDYL2	101	Q8N8U2
AARGETHKPLKPALK	CLCN2	686	P51788
THKPLKPALKRGPSV	CLCN2	691	P51788
GLGPRKGTHLLKILK	SUPT6H	991	Q7KZ85
KRNGAPHLPKIGDIK	RAPGEF2	481	Q9Y4G8
KFGLKSHVSKPPLRP	UST	361	Q9Y2C2
GFKPPREHLNSKTKG	SETDB2	521	Q96T68
RLPFKKLKVNEHGSP	ZBTB21	491	Q9ULJ3
RAPLTKDSGKPLHIK	ZC3H3	931	Q8IXZ2
PGQHGKTPSLLKIQK	ZNF714	531	Q96N38
KTHRQSILAKLPPKG	RORC	456	P51449
GRLKARKHLKPEQPA	SPEN	956	Q96T58
VPRKLLSHGKKPFSQ	RPL6	121	Q02878
LHVIPRAKKGAEGKP	RRP9	181	O43818
LKHKLKTPRPGCQGQ	TICAM1	26	Q8IUC6
HPKTGKRKRVAGDLP	WWOX	46	Q9NZC7
EHAPAGRPIHKGKSK	TRABD2A	351	Q86V40
QQRTKVHLPGHKKGP	YLPM1	306	P49750
RGLHLQALKPTKPGL	SERPINA10	126	Q9UK55
GFGLQHPALQKRKLP	ZBTB39	571	O15060
LQGHPKIHIGEKPRK	ZNF112	486	Q9UJU3
KKKNKRIGRPPGGHS	SFMBT1	641	Q9UHJ3
GKLPSRGPKHLKLTP	WEE2	126	P0C1S8
RGPKHLKLTPAPLKD	WEE2	131	P0C1S8
PGSGHVKQKAVKRPA	TRIM2	441	Q9C040
LALGNAQKLPKGKRP	ABI3BP	16	Q7Z7G0
TPKHLVRGEGQKAKL	TRBV16	26	A0A087WV62
HPKALKDVKGQIGAP	PC	1101	P11498
LLHSKPPKPTQARGK	SNAPC2	136	Q13487
RSHGKKLPPASLKHR	PPIP5K1	1046	Q6PFW1
KIPKGHGSPISRKNS	ZNF391	76	Q9UJN7
IPHGRKNHSDKGPKP	LIPA	66	P38571