Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	20-hydroxy-leukotriene B4 omega oxidase activity	CYP4F2 CYP4F3	4.32e-06	2	42	2	GO:0097258
GeneOntologyMolecularFunction	20-aldehyde-leukotriene B4 20-monooxygenase activity	CYP4F2 CYP4F3	4.32e-06	2	42	2	GO:0097259
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F2 CYP4F3	4.30e-05	5	42	2	GO:0052871
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F2 CYP4F3	9.01e-05	7	42	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F2 CYP4F3	9.01e-05	7	42	2	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F2 CYP4F3	1.92e-04	10	42	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.92e-04	10	42	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.92e-04	10	42	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	3.32e-04	13	42	2	GO:0016713
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F2 CYP4F3	1.16e-03	24	42	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F2 CYP4F3	1.47e-03	27	42	2	GO:0008391
GeneOntologyMolecularFunction	ATP hydrolysis activity	PMS2P1 ORC1 ATAD2 DHX37 ATP2C2	2.23e-03	441	42	5	GO:0016887
GeneOntologyMolecularFunction	aromatase activity	CYP4F2 CYP4F3	2.46e-03	35	42	2	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	3.20e-03	40	42	2	GO:0016709
GeneOntologyMolecularFunction	chromatin binding	SREBF1 SFMBT1 ORC1 EZH2 ATAD2 TRIM24	4.24e-03	739	42	6	GO:0003682
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F2 CYP4F3	6.04e-05	6	42	2	GO:0036101
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F2 CYP4F3	8.45e-05	7	42	2	GO:0036102
GeneOntologyBiologicalProcess	positive regulation of peptidyl-lysine acetylation	DIP2B DIP2A	8.45e-05	7	42	2	GO:2000758
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F2 CYP4F3	1.12e-04	8	42	2	GO:0036100
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F2 CYP4F3	2.20e-04	11	42	2	GO:1901523
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F2 CYP4F3	2.64e-04	12	42	2	GO:0042758
GeneOntologyBiologicalProcess	regulation of peptidyl-lysine acetylation	DIP2B DIP2A	2.64e-04	12	42	2	GO:2000756
Domain	DMAP_binding	DIP2C DIP2B DIP2A	9.79e-08	5	41	3	PF06464
Domain	DMAP1-bd	DIP2C DIP2B DIP2A	1.95e-07	6	41	3	IPR010506
Domain	DMAP_binding	DIP2C DIP2B DIP2A	1.95e-07	6	41	3	SM01137
Domain	BAT2_N	PRRC2C PRRC2B	1.41e-05	3	41	2	PF07001
Domain	BAT2_N	PRRC2C PRRC2B	1.41e-05	3	41	2	IPR009738
Domain	PRRC2	PRRC2C PRRC2B	1.41e-05	3	41	2	IPR033184
Domain	AMP-binding	DIP2C DIP2B DIP2A	3.83e-05	30	41	3	PF00501
Domain	AMP-dep_Synth/Lig	DIP2C DIP2B DIP2A	3.83e-05	30	41	3	IPR000873
Domain	G_patch	AGGF1 RBM17	1.16e-03	23	41	2	SM00443
Domain	G_patch_dom	AGGF1 RBM17	1.16e-03	23	41	2	IPR000467
Domain	G_PATCH	AGGF1 RBM17	1.16e-03	23	41	2	PS50174
Domain	G-patch	AGGF1 RBM17	1.16e-03	23	41	2	PF01585
Domain	BROMODOMAIN_1	ATAD2 TRIM24	2.98e-03	37	41	2	PS00633
Domain	Bromodomain	ATAD2 TRIM24	3.14e-03	38	41	2	PF00439
Domain	BROMODOMAIN_2	ATAD2 TRIM24	3.65e-03	41	41	2	PS50014
Domain	BROMO	ATAD2 TRIM24	3.83e-03	42	41	2	SM00297
Domain	Bromodomain	ATAD2 TRIM24	3.83e-03	42	41	2	IPR001487
Domain	-	ATAD2 TRIM24	3.83e-03	42	41	2	1.20.920.10
Domain	Cyt_P450_E_grp-I	CYP4F2 CYP4F3	4.38e-03	45	41	2	IPR002401
Domain	AAA	ORC1 ATAD2	5.82e-03	52	41	2	PF00004
Domain	Cyt_P450_CS	CYP4F2 CYP4F3	6.04e-03	53	41	2	IPR017972
Domain	ATPase_AAA_core	ORC1 ATAD2	6.26e-03	54	41	2	IPR003959
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3	3.25e-04	12	32	2	MM14845
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3	3.25e-04	12	32	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3	3.25e-04	12	32	2	M27128
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4F2 CYP4F3	4.47e-04	14	32	2	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3	5.15e-04	15	32	2	M27126
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3	7.47e-04	18	32	2	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3	7.47e-04	18	32	2	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F3	1.02e-03	21	32	2	M27137
Pubmed	CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.	DIP2C DIP2B DIP2A	1.64e-09	3	42	3	17236128
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SREBF1 DOCK5 DIP2B DIP2A NOL9 EZH2 DHX37 PRRC2C PRRC2B	6.77e-08	650	42	9	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NOL9 SRRM2 ATAD2 TRIP12 DHX37 PRRC2C CANX PRRC2B	9.95e-07	653	42	8	22586326
Pubmed	Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells.	SH3PXD2B EZH2	1.42e-06	2	42	2	38672463
Pubmed	Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E).	SREBF1 CYP4F2	1.42e-06	2	42	2	28628909
Pubmed	Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.	DIP2C DIP2A	1.42e-06	2	42	2	12137943
Pubmed	Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.	CYP4F2 CYP4F3	1.42e-06	2	42	2	8026587
Pubmed	Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex.	EZH2 ATAD2	1.42e-06	2	42	2	23038103
Pubmed	Multi-omics analysis to identify susceptibility genes for colorectal cancer.	SFMBT1 DIP2B	1.42e-06	2	42	2	33481017
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TBC1D12 DOCK5 PAPOLA SRRM2 KIAA1217 CANX RBM17	2.52e-06	513	42	7	25798074
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	AGGF1 ZCCHC17 NOL9 QARS1 TRIP12 DHX37 PRRC2C RBM17	3.04e-06	759	42	8	35915203
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DIP2B GPRIN1 PAPOLA EZH2 SRRM2 ATAD2 TRIP12 WDR44	3.51e-06	774	42	8	15302935
Pubmed	Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.	CYP4F2 CYP4F3	4.27e-06	3	42	2	15145985
Pubmed	ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.	EZH2 ATAD2	4.27e-06	3	42	2	20864510
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	DIP2C DIP2B DIP2A	5.25e-06	28	42	3	31600191
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	SRRM2 PRRC2C RBM17	5.85e-06	29	42	3	17577209
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F2 CYP4F3	8.53e-06	4	42	2	18065749
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	DIP2B DIP2A ZCCHC17 NOL9 SRRM2 KIAA1217 CANX PRRC2B WDR44 MRPL2	8.78e-06	1496	42	10	32877691
Pubmed	Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.	CYP4F2 CYP4F3	1.42e-05	5	42	2	18577768
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SREBF1 SFMBT1 DOCK5 ORC1 NOL9 EZH2 SRRM2 TRIP12 RBM17	1.95e-05	1294	42	9	30804502
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	LRPAP1 QARS1 SRRM2 TRIP12 DHX37 PRRC2C CANX PRRC2B RBM17	1.99e-05	1297	42	9	33545068
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ORC1 NOL9 QARS1 SRRM2 ATAD2 TRIP12 DHX37 CANX	2.08e-05	989	42	8	36424410
Pubmed	EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma.	EZH2 TRIP12	2.13e-05	6	42	2	38031139
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F2 CYP4F3	2.13e-05	6	42	2	9068972
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	ZCCHC17 QARS1 DHX37 CANX PRRC2B MRPL2 RBM17	2.34e-05	723	42	7	34133714
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SH3PXD2B QARS1 TRIP12 DHX37 PRRC2C PRRC2B RBM17	2.36e-05	724	42	7	36232890
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	CELSR1 QARS1 TRIP12 KIAA1217 CANX PRRC2B MRPL2	2.53e-05	732	42	7	34732716
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DIP2A GPRIN1 QARS1 TRIP12 DHX37 HYDIN	2.80e-05	497	42	6	36774506
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	SREBF1 DOCK5 NOL9 TRIM24 DHX37 CANX RBM17	3.05e-05	754	42	7	35906200
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ZCCHC17 NOL9 QARS1 TRIP12 DHX37 PRRC2C ITIH2 PRRC2B RBM17	3.08e-05	1371	42	9	36244648
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SFMBT1 DOCK5 ZCCHC17 GPRIN1 TRIP12 GGA1 PRRC2B	3.69e-05	777	42	7	35844135
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SRRM2 CANX WDR44 RBM17	4.53e-05	163	42	4	22113938
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SREBF1 DIP2C ORC1 DIP2A SH3PXD2B CELSR1 GGA1 PRRC2B	4.57e-05	1105	42	8	35748872
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	NOL9 QARS1 SRRM2 ATAD2 TRIP12 DHX37 RBM17	6.36e-05	847	42	7	35850772
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SFMBT1 AGGF1 NOL9 QARS1 TRIM24 TRIP12 PRRC2C	6.85e-05	857	42	7	25609649
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZCCHC17 SRRM2 TRIP12 PRRC2C PRRC2B	7.27e-05	361	42	5	26167880
Pubmed	Functional proteomics mapping of a human signaling pathway.	SPRTN PAPOLA QARS1 TRIP12 GGA1 CANX	7.32e-05	591	42	6	15231748
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SFMBT1 ATAD2 TRIM24	1.04e-04	75	42	3	25593309
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	NOL9 QARS1 TRIP12 DHX37 PRRC2C ITIH2 KIAA1217 CANX	1.12e-04	1257	42	8	36526897
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GPRIN1 PAPOLA PRRC2C KIAA1217 PRRC2B WDR44 RBM17	1.17e-04	934	42	7	33916271
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B SH3PXD2B NOL9 PRRC2C KIAA1217 CANX PRRC2B	1.41e-04	963	42	7	28671696
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	NOL9 EZH2 ATAD2	1.85e-04	91	42	3	34780483
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	DIP2B ZCCHC17 CORO7 TRIP12 PRRC2C PRRC2B	1.86e-04	701	42	6	30196744
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ORC1 NOL9 CORO7 QARS1 SRRM2 ATAD2 TRIP12 DHX37	1.86e-04	1353	42	8	29467282
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	NOL9 PRRC2C KIAA1217 CANX	2.46e-04	253	42	4	29911972
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	NOL9 SRRM2 ATAD2 RBM17	2.69e-04	259	42	4	30404004
Pubmed	Human transcription factor protein interaction networks.	QARS1 SRRM2 TRIM24 DHX37 PRRC2C CANX PRRC2B MRPL2	2.70e-04	1429	42	8	35140242
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DIP2B ZCCHC17 SRRM2 TRIP12 DHX37 CANX RBM17	2.88e-04	1082	42	7	38697112
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	TRIP12 RBM17	2.95e-04	21	42	2	30179224
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	SH3PXD2B HYDIN	2.95e-04	21	42	2	26234751
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	QARS1 SRRM2 PRRC2C CANX	3.06e-04	268	42	4	33024031
Pubmed	PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.	PRRC2C PRRC2B	3.24e-04	22	42	2	38507412
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	BCAR3 EZH2 SRRM2 TRIP12 WDR44	3.39e-04	503	42	5	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	PAPOLA QARS1 SRRM2 CANX RBM17	3.49e-04	506	42	5	30890647
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	LRPAP1 DIP2A NOL9 GPRIN1 SRRM2 TRIM24 CANX MRPL2	3.53e-04	1487	42	8	33957083
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	AGGF1 SRRM2 RBM17	3.68e-04	115	42	3	17332742
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	TRIM24 TRIP12 PRRC2B	3.77e-04	116	42	3	30804394
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZCCHC17 SRRM2 PRRC2C CANX PRRC2B MRPL2	3.94e-04	807	42	6	22681889
Pubmed	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	HYDIN ATP2C2	4.90e-04	27	42	2	23144326
Pubmed	Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.	ITIH2 RBM17	4.90e-04	27	42	2	21510876
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SH3PXD2B GPRIN1 PRRC2C PRRC2B WDR44	5.06e-04	549	42	5	38280479
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SH3PXD2B ZCCHC17 GGA1 DHX37 KIAA1217 PRRC2B	5.28e-04	853	42	6	28718761
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	QARS1 SRRM2 PRRC2C MRPL2 RBM17	5.44e-04	558	42	5	27591049
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B SH3PXD2B SRRM2 TRIP12 PRRC2C KIAA1217	5.55e-04	861	42	6	36931259
Pubmed	Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.	TRIM24 CANX	5.66e-04	29	42	2	31330130
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SREBF1 TRIM24 TRIP12 CANX	6.12e-04	322	42	4	26514267
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	ZCCHC17 SPRTN CORO7 GGA1	6.12e-04	322	42	4	39098523
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	DIP2B PRRC2C CANX PRRC2B	6.63e-04	329	42	4	34316702
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	DIP2C LRPAP1 CELSR1	6.81e-04	142	42	3	19851296
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	SH3PXD2B SPRTN PRRC2C PRRC2B	6.86e-04	332	42	4	37433992
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SPRTN PRRC2C KIAA1217 CANX PRRC2B	6.89e-04	588	42	5	38580884
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	DIP2C LRPAP1 CELSR1	6.95e-04	143	42	3	20198315
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PAPOLA EZH2 SRRM2 RBM17	7.58e-04	341	42	4	32971831
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	DIP2B SH3PXD2B SRRM2 CANX	7.83e-04	344	42	4	30333137
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	NOL9 SRRM2 PRRC2C CANX RBM17	7.83e-04	605	42	5	28977666
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	QARS1 TRIP12 DHX37	7.98e-04	150	42	3	30154076
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	EZH2 ATAD2 TRIM24 TRIP12 DHX37	8.01e-04	608	42	5	36089195
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	DIP2B LRPAP1	8.26e-04	35	42	2	23969696
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	QARS1 SRRM2 PRRC2C PRRC2B RBM17	8.43e-04	615	42	5	31048545
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	ZCCHC17 BCAR3 SRRM2 DHX37 CANX RBM17	9.21e-04	949	42	6	36574265
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	CORO7 SRRM2 PRRC2C KIAA1217	9.26e-04	360	42	4	33111431
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ZCCHC17 NOL9 QARS1 SRRM2 TRIP12 DHX37 CANX	9.32e-04	1318	42	7	30463901
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	NOL9 QARS1 SRRM2 PRRC2C CANX	1.01e-03	641	42	5	36057605
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	DIP2B DIP2A GPRIN1 WDR44	1.10e-03	377	42	4	38117590
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SH3PXD2B NOL9 GPRIN1 QARS1 CANX PRRC2B RBM17	1.15e-03	1367	42	7	32687490
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	QARS1 SRRM2 PRRC2C MRPL2	1.18e-03	384	42	4	31059266
Interaction	KCNE3 interactions	DIP2C ORC1 DIP2A SPRTN GPRIN1 QARS1 TRIP12 WDR44	1.51e-07	296	42	8	int:KCNE3
Interaction	FGFR4 interactions	DIP2B LRPAP1 DIP2A SH3PXD2B GPRIN1 GGA1 CANX WDR44	4.01e-06	458	42	8	int:FGFR4
Interaction	DHX15 interactions	AGGF1 EZH2 QARS1 SRRM2 TRIM24 GGA1 DHX37 RBM17	7.85e-06	502	42	8	int:DHX15
Interaction	H3C1 interactions	SFMBT1 PIEZO2 GPRIN1 EZH2 ATAD2 TRIM24 TRIP12 DHX37 PRRC2C ITIH2	1.21e-05	901	42	10	int:H3C1
Cytoband	Ensembl 112 genes in cytogenetic band chr5q35	SH3PXD2B GPRIN1 CANX	1.31e-03	235	42	3	chr5q35
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	AGGF1 RBM17	3.84e-04	22	24	2	579
GeneFamily	Cytochrome P450 family 4	CYP4F2 CYP4F3	1.03e-03	36	24	2	1003
GeneFamily	AAA ATPases	ORC1 ATAD2	2.23e-03	53	24	2	413
Coexpression	PATIL_LIVER_CANCER	SH3PXD2B ZCCHC17 PIEZO2 EZH2 ATAD2 TRIM24 PRRC2C CANX	8.58e-06	660	42	8	M1195
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_1000	SFMBT1 PAPOLA QARS1 TRIP12 PRRC2C KIAA1217 CANX	8.03e-06	375	42	7	gudmap_developingKidney_e15.5_cortic collect duct_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500	SFMBT1 PAPOLA QARS1 PRRC2C CANX	4.63e-05	201	42	5	gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	SFMBT1 CELSR1 PAPOLA QARS1 TRIP12 PRRC2C KIAA1217 CANX	1.18e-04	774	42	8	gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500	SFMBT1 CELSR1 PAPOLA QARS1 PRRC2C CANX	1.31e-04	402	42	6	gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000	SFMBT1 CELSR1 PAPOLA QARS1 ATAD2 PRRC2C KIAA1217 CANX	1.42e-04	795	42	8	gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Proximal Tubules_emap-28005_k-means-cluster#3_top-relative-expression-ranked_1000	PAPOLA QARS1 PRRC2C CANX	2.29e-04	152	42	4	gudmap_developingKidney_e15.5_Proximal Tubules_1000_k3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 FAR2 EZH2 ATAD2	2.31e-05	177	42	4	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B SRRM2 PRRC2C CANX	3.23e-05	193	42	4	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B SRRM2 PRRC2C CANX	3.23e-05	193	42	4	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B SRRM2 PRRC2C CANX	3.23e-05	193	42	4	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B SRRM2 PRRC2C CANX	3.23e-05	193	42	4	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	COVID_vent-Myeloid-Monocytic-Developing_Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CYP4F2 CYP4F3 FAR2 ATP2C2	3.37e-05	195	42	4	de23409b1b4146b8ae286850b829ec8dceed0117
ToppCell	severe-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DIP2A CYP4F3 FAR2 ATP2C2	3.50e-05	197	42	4	9599319dd1f80c81356a8624131566cc76d77d7e
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	SRRM2 GGA1 DHX37 PRRC2C	3.50e-05	197	42	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	COVID-19_Severe-immature_Neutrophil\|COVID-19_Severe / Disease condition and Cell class	CYP4F3 FAR2 ATAD2 ATP2C2	3.64e-05	199	42	4	f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK5 CELSR1 KIAA1217 ATP2C2	3.64e-05	199	42	4	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	COVID-19_Severe-immature_Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	CYP4F3 FAR2 ATAD2 ATP2C2	3.64e-05	199	42	4	42ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell	(09)_Ionocytes-(4)_1wkpi\|(09)_Ionocytes / shred by cell type and Timepoint	LRPAP1 ZCCHC17	1.94e-04	22	42	2	b35fb230042a027b10ef3e7ef09bf13ea1cdc506
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DOCK5 CYP4F2 CYP4F3	3.23e-04	142	42	3	191a13bba143ecdfc2bfd797c3ac191481388298
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DOCK5 CYP4F2 CYP4F3	3.30e-04	143	42	3	b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	DIP2B CYP4F3 WDR44	4.25e-04	156	42	3	ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	4.25e-04	156	42	3	955547dfeb1b1ad4957b4338701055726b22619f
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ORC1 EZH2 ATAD2	4.92e-04	164	42	3	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPRIN1 EZH2 ATAD2	5.01e-04	165	42	3	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK5 SH3PXD2B PIEZO2	5.18e-04	167	42	3	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	CELSR1 KIAA1217 ATP2C2	5.18e-04	167	42	3	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	5.18e-04	167	42	3	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK5 DIP2C KIAA1217	5.27e-04	168	42	3	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	healthy_donor-Myeloid-Monocytic-Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	DOCK5 CYP4F2 CYP4F3	5.27e-04	168	42	3	04259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	5.37e-04	169	42	3	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ORC1 EZH2 ATAD2	5.37e-04	169	42	3	20fbf78382fb0ba9a63ab1aa0abc615476994ac5
ToppCell	Dividing_Macrophages-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	ORC1 EZH2 ATAD2	5.37e-04	169	42	3	eb0c993ef2eea73bc4881182520922ce9ae9368f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	5.37e-04	169	42	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	5.55e-04	171	42	3	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	5.55e-04	171	42	3	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	ORC1 EZH2 ATAD2	5.65e-04	172	42	3	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ORC1 ATAD2 DHX37	5.65e-04	172	42	3	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK5 BCAR3 ATAD2	5.84e-04	174	42	3	65147b0f8c2ccadd5685430d31081520c157536a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DIP2A KIAA1217 ATP2C2	5.84e-04	174	42	3	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 PIEZO2 ITIH2	5.94e-04	175	42	3	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ORC1 EZH2 ATAD2	5.94e-04	175	42	3	86dfce849b2ec023a72f7e887fa681b117155e51
ToppCell	droplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC1 SPRTN EZH2	6.04e-04	176	42	3	b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPRTN EZH2 ATAD2	6.04e-04	176	42	3	9e719e6323597ecfc758c957256872cd4ae24d4d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.14e-04	177	42	3	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	6.14e-04	177	42	3	f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.14e-04	177	42	3	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.14e-04	177	42	3	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIEZO2 GPRIN1 ATAD2	6.14e-04	177	42	3	0e74980a7686c31fcf1476b8f19a3392541df240
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DIP2A KIAA1217 ATP2C2	6.14e-04	177	42	3	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ORC1 SH3PXD2B BCAR3	6.24e-04	178	42	3	de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell	Dividing_Macrophages-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ORC1 EZH2 ATAD2	6.24e-04	178	42	3	1893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	6.34e-04	179	42	3	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 KIAA1217 ATP2C2	6.34e-04	179	42	3	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ORC1 EZH2 ATAD2	6.34e-04	179	42	3	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 KIAA1217 ATP2C2	6.34e-04	179	42	3	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CELSR1 KIAA1217 ATP2C2	6.45e-04	180	42	3	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DIP2A KIAA1217 ATP2C2	6.55e-04	181	42	3	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.66e-04	182	42	3	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CELSR1 KIAA1217 ATP2C2	6.66e-04	182	42	3	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.66e-04	182	42	3	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	6.66e-04	182	42	3	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CELSR1 KIAA1217 ATP2C2	6.66e-04	182	42	3	05c167158815bf25d509df59ab386e1990712765
ToppCell	URO-Lymphocyte-T_NK-dnT\|URO / Disease, Lineage and Cell Type	SFMBT1 NOL9 EZH2	6.66e-04	182	42	3	f2b1c524301d0f2d1b69c46f3653fd53c21c3aa0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4F2 CYP4F3 SRRM2	6.76e-04	183	42	3	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC1 EZH2 ATAD2	6.76e-04	183	42	3	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	IIF-Lymphocyte-T_NK-T_NK_proliferative\|IIF / Disease, Lineage and Cell Type	ORC1 EZH2 ATAD2	6.87e-04	184	42	3	ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DIP2C SH3PXD2B BCAR3	6.87e-04	184	42	3	8fa30789c9d583188667cf375d2218e392dd40bc
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	ORC1 EZH2 ATAD2	6.87e-04	184	42	3	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	EZH2 SRRM2 PRRC2C	6.98e-04	185	42	3	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYP4F3 FAR2 ATP2C2	6.98e-04	185	42	3	d747bc91fc276f12a5572ab0223fc71f829a5110
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DIP2C SH3PXD2B BCAR3	6.98e-04	185	42	3	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 PIEZO2 KIAA1217	6.98e-04	185	42	3	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ORC1 EZH2 ATAD2	7.09e-04	186	42	3	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2C SH3PXD2B BCAR3	7.20e-04	187	42	3	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK5 DIP2A EZH2	7.20e-04	187	42	3	d17352f769c3c66601b65d060626eecff41b0482
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	SFMBT1 ATAD2 CANX	7.20e-04	187	42	3	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 EZH2 ATAD2	7.20e-04	187	42	3	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2C SH3PXD2B BCAR3	7.20e-04	187	42	3	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 EZH2 ATAD2	7.20e-04	187	42	3	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	10x5'-Liver-Lymphocytic_NK-Cycling_NK\|Liver / Manually curated celltypes from each tissue	ORC1 EZH2 ATAD2	7.31e-04	188	42	3	5eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HYDIN KIAA1217 ATP2C2	7.31e-04	188	42	3	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-T_NK_proliferative\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ORC1 EZH2 ATAD2	7.31e-04	188	42	3	6c05797a5d0635d89ffcf4aca52178687129ccb4
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	CELSR1 KIAA1217 ATP2C2	7.31e-04	188	42	3	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2C SH3PXD2B BCAR3	7.42e-04	189	42	3	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3PXD2B BCAR3 CANX	7.42e-04	189	42	3	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYP4F3 FAR2 ATP2C2	7.42e-04	189	42	3	94dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCell	droplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2C SH3PXD2B BCAR3	7.42e-04	189	42	3	6d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYP4F3 FAR2 ATP2C2	7.42e-04	189	42	3	3b35022c0619df6db234613aa53a076899ca9562
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4F3 FAR2 ATP2C2	7.42e-04	189	42	3	358ff514f1c8aa46067208ddf1b68396d789c130
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3PXD2B BCAR3 CANX	7.54e-04	190	42	3	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	7.54e-04	190	42	3	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP4F3 FAR2 ATP2C2	7.54e-04	190	42	3	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	7.54e-04	190	42	3	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	control-Myeloid-Immature_Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYP4F3 FAR2 ATP2C2	7.54e-04	190	42	3	38e83337c70c8734b63f8589ba59e0f98603f94c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 SH3PXD2B PIEZO2	7.54e-04	190	42	3	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	CELSR1 KIAA1217 ATP2C2	7.54e-04	190	42	3	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4F3 FAR2 ATP2C2	7.65e-04	191	42	3	6c1283d51a845cff67ed5e500f7e944165297b53
ToppCell	facs-Pancreas-Endocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPRIN1 PAPOLA CANX	7.65e-04	191	42	3	b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ORC1 EZH2 ATAD2	7.65e-04	191	42	3	50854384fdaa0efa2e3227659d544ed09ac102f2
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CELSR1 KIAA1217 ATP2C2	7.65e-04	191	42	3	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ORC1 EZH2 ATAD2	7.65e-04	191	42	3	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ORC1 EZH2 ATAD2	7.65e-04	191	42	3	56b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ORC1 EZH2 ATAD2	7.65e-04	191	42	3	b85a0978dc1e8af4f49423f56dcfd52efce09ed1
ToppCell	facs-Skin-Anagen-3m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 BCAR3 QARS1	7.77e-04	192	42	3	ec1fd2fb6e71f87189d66261909a84e2be63cacb
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP4F3 FAR2 ATP2C2	7.77e-04	192	42	3	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	CELSR1 KIAA1217 ATP2C2	7.77e-04	192	42	3	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B SRRM2	2.41e-04	17	40	2	DOID:0060307 (is_implicated_in)
Disease	suntan	PIEZO2 PAPOLA KIAA1217	3.72e-04	103	40	3	EFO_0004279
Disease	obsolete_red blood cell distribution width	TBC1D12 PMS2P1 DOCK5 DIP2B NOL9 EZH2 PRRC2C KIAA1217	3.85e-04	1347	40	8	EFO_0005192
Disease	Liver carcinoma	SREBF1 ORC1 SPRTN EZH2 TRIM24	5.88e-04	507	40	5	C2239176
Disease	androgenetic alopecia	DIP2B PIEZO2 FAR2	7.83e-04	133	40	3	EFO_0004191
Disease	response to platinum based chemotherapy, drug allergy	DOCK5 ATAD2	1.10e-03	36	40	2	EFO_0004647, EFO_0009482
Disease	revision of total hip arthroplasty, aseptic loosening	CELSR1 WDR44	1.49e-03	42	40	2	EFO_0010725, EFO_0020973
Disease	myeloid white cell count	SREBF1 TBC1D12 DIP2A BCAR3 GGA1 CANX	1.54e-03	937	40	6	EFO_0007988
Disease	smoking status measurement, carotid artery intima media thickness	DIP2C TRIP12	1.94e-03	48	40	2	EFO_0006527, EFO_0007117
Disease	pulse pressure measurement	TBC1D12 DIP2B DIP2A PIEZO2 CORO7 HYDIN KIAA1217	2.43e-03	1392	40	7	EFO_0005763
Disease	lymphocyte count	SREBF1 DIP2A CYP4F3 CORO7 TRIP12 CANX RBM17	3.22e-03	1464	40	7	EFO_0004587
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	SREBF1 EZH2	3.53e-03	65	40	2	DOID:0080208 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPPPQSSRRKNFEFE	TBC1D12	376	O60347
RPNEFESKFLPPENK	BCAR3	516	O75815
RERFTENFPETKPQK	AGGF1	686	Q8N302
FRVFTKPVDPDEVPD	ATAD2	1006	Q6PL18
DFFRPPEEKEGPLLR	CELSR1	2286	Q9NYQ6
QPKPSPKRESGEEFR	LRPAP1	41	P30533
VEPVDKDAFRQPPRS	ATP2C2	781	O75185
RERKPKTEEFPSFIP	OVOS1	961	Q6IE37
FEKIPFERPFRRPNA	FAR2	326	Q96K12
REPEEAHKEKPYRRP	NOL9	681	Q5SY16
IFNERPGKDPEKPEA	ITIH2	871	P19823
PRVRKEFFQDDVFPD	CORO7	816	P57737
ESRPPRKFPSDKIFE	EZH2	211	Q15910
RPKRPPLKEFFVDDS	DIP2B	286	Q9P265
PPRPKNVIFEDEEKS	GGA1	161	Q9UJY5
EPLGEKERREVFFPP	PMS2P1	146	A4D2B8
FPAPKENPDKEEFRT	PAPOLA	421	P51003
LFEDDSDPPPKKRAR	ORC1	71	Q13415
FAPKKRVPPFSEEVF	HYDIN	4491	Q4G0P3
RPFRKGEKDPDNEFA	DOCK5	1466	Q9H7D0
KIPNPDFFEDLEPFR	CANX	401	P27824
KRPKRPPLREFFVDD	DIP2C	266	Q9Y2E4
DPFRFDPENIKERSP	CYP4F2	441	P78329
DPFRFDPKNIKERSP	CYP4F3	441	Q08477
KRPKRPPLKEFFVDD	DIP2A	281	Q14689
SDKVDPVFPRKEEPR	GPRIN1	246	Q7Z2K8
KAFPPSRARPQEKDD	DHX37	491	Q8IY37
RTDFKEEPEPGFKRL	QARS1	616	P47897
PRQKDKFSPFPVQDR	SRRM2	1181	Q9UQ35
AADKRPPKFERKFDP	PRRC2C	1401	Q9Y520
PPKFERKFDPARERP	PRRC2C	1406	Q9Y520
PDRASPSRQAFKKEP	KIAA1217	501	Q5T5P2
SPVFEDSKAKPEQRP	SREBF1	461	P36956
PEKRFPKPEFRNESE	TRIM24	1006	O15164
AEFEKPDPTRNPSRK	ZCCHC17	171	Q9NP64
FFETRPEDLNPPKEE	SH3PXD2B	121	A1X283
KELPRDFPYEEDSRP	RBM17	186	Q96I25
LKKEDEEPPRRSAFQ	PIEZO2	1566	Q9H5I5
EDPDDKNAPFRQRPF	WDR44	586	Q5JSH3
FRQQSIEDKEDKPPP	PRRC2B	476	Q5JSZ5
RFRPEETKSGPFEEK	MRPL2	111	Q5T653
EDTFPNKRPRLEDKT	SPRTN	401	Q9H040
FSDDENKPPSPKEIR	SFMBT1	766	Q9UHJ3
RRPKYSPPRDDDKVD	TRIP12	1011	Q14669