Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C PDPK2P GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	3.66e-25	446	192	38	GO:0004674
GeneOntologyMolecularFunction	protein serine kinase activity	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	5.33e-25	363	192	35	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 BAZ1B CAMK1 STK32C PDPK2P GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	1.54e-21	600	192	39	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 BAZ1B CAMK1 STK32C PDPK2P PIP5K1C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	7.25e-20	709	192	40	GO:0016773
GeneOntologyMolecularFunction	kinase activity	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 BAZ1B CAMK1 STK32C PDPK2P PIP5K1C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	1.02e-18	764	192	40	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 GNPTAB AAK1 BAZ1B CAMK1 STK32C PDPK2P PIP5K1C GRK1 MAPK14 RPAP1 MAP4K1 MASTL SRPK3 PKN1 ATM SELENOI MAPK3 MAPK6 NLK	5.81e-18	938	192	43	GO:0016772
GeneOntologyMolecularFunction	histone kinase activity	RPS6KA5 BUB1 RPS6KA4 BAZ1B PKN1 ATM	2.31e-07	28	192	6	GO:0035173
GeneOntologyMolecularFunction	ribosomal protein S6 kinase activity	RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4	2.84e-07	7	192	4	GO:0004711
GeneOntologyMolecularFunction	MAP kinase activity	MAPK12 MAPK14 MAPK3 MAPK6 NLK	3.13e-07	16	192	5	GO:0004707
GeneOntologyMolecularFunction	magnesium ion binding	RPS6KA5 RPS6KA2 RPS6KA3 LRRK2 MAPK12 MAST4 GCLC RPS6KA6 ATP11C RPS6KA4 NLK	2.84e-05	247	192	11	GO:0000287
GeneOntologyMolecularFunction	3-phosphoinositide-dependent protein kinase activity	PDPK1 PDPK2P	9.20e-05	2	192	2	GO:0004676
GeneOntologyMolecularFunction	histone H3 kinase activity	RPS6KA5 RPS6KA4 PKN1	1.81e-04	12	192	3	GO:0140996
GeneOntologyMolecularFunction	histone H2A kinase activity	RPS6KA5 BUB1	2.74e-04	3	192	2	GO:0140995
GeneOntologyMolecularFunction	histone H3S28 kinase activity	RPS6KA5 RPS6KA4	2.74e-04	3	192	2	GO:0044022
GeneOntologyMolecularFunction	protein phosphatase activator activity	PPP4R3C PPP4R3A PPP4R3B	5.39e-04	17	192	3	GO:0072542
GeneOntologyMolecularFunction	histone H3S10 kinase activity	RPS6KA5 RPS6KA4	5.45e-04	4	192	2	GO:0035175
GeneOntologyMolecularFunction	phosphatase activator activity	PPP4R3C PPP4R3A PPP4R3B	8.84e-04	20	192	3	GO:0019211
GeneOntologyMolecularFunction	histone H2AX kinase activity	BAZ1B ATM	9.02e-04	5	192	2	GO:0141003
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K4 MAP4K1	1.35e-03	6	192	2	GO:0008349
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	PLK2 RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 LRRK2 CHUK TLK1 MAPK12 MAST4 CSNK1G1 RPS6KA6 EPM2A RPS6KA4 CAMK1 STK32C PDPK2P MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM NLK	1.21e-15	307	191	24	GO:0018105
GeneOntologyBiologicalProcess	peptidyl-serine modification	PLK2 RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 LRRK2 CHUK TLK1 MAPK12 MAST4 CSNK1G1 RPS6KA6 EPM2A RPS6KA4 CAMK1 STK32C PDPK2P MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM NLK	2.86e-15	319	191	24	GO:0018209
GeneOntologyBiologicalProcess	peptidyl-amino acid modification	PLK2 RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 LRRK2 CHUK TLK1 MAPK12 MAST4 CSNK1G1 RPS6KA6 EPM2A RPS6KA4 CAMK1 STK32C PDPK2P VIPAS39 MAPK14 MAP4K1 DPY19L4 MASTL SRPK3 PKN1 ATM CTNNB1 MAPK3 ZDHHC11 NLK	2.74e-08	976	191	29	GO:0018193
GeneOntologyBiologicalProcess	positive regulation of autophagy	PLK2 LRRK2 ATG2A TPCN1 PLK3 EPM2A CERS1 MAPK3 SMCR8 GPSM1	5.04e-06	173	191	10	GO:0010508
GeneOntologyBiologicalProcess	phospholipid homeostasis	ABCA1 CETP LYST GPAM	1.97e-05	18	191	4	GO:0055091
GeneOntologyCellularComponent	protein phosphatase 4 complex	PPP4R3C PPP4R3A PPP4R3B	1.49e-05	6	192	3	GO:0030289
Domain	Ser/Thr_kinase_AS	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	2.81e-22	357	190	33	IPR008271
Domain	S_TKc	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	3.36e-22	359	190	33	SM00220
Domain	PROTEIN_KINASE_ST	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	4.36e-22	362	190	33	PS00108
Domain	Pkinase	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	2.18e-21	381	190	33	PF00069
Domain	Kinase-like_dom	TRPM6 PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 PIK3CG CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 ATM MAPK3 MAPK6 NLK	1.93e-19	542	190	36	IPR011009
Domain	PROTEIN_KINASE_ATP	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	6.79e-19	459	190	33	PS00107
Domain	Prot_kinase_dom	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	4.60e-18	489	190	33	IPR000719
Domain	PROTEIN_KINASE_DOM	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 MAST4 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 ANKK1 RPS6KA4 CAMKK1 AAK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 MASTL SRPK3 PKN1 MAPK3 MAPK6 NLK	5.87e-18	493	190	33	PS50011
Domain	Protein_kinase_ATP_BS	PLK2 RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 LRRK2 DAPK3 CHUK NEK4 TLK1 MAPK12 CSNK1G1 BUB1 RPS6KA6 MAP4K4 PLK3 RPS6KA4 CAMKK1 CAMK1 STK32C GRK1 MAPK14 MAP4K1 SRPK3 PKN1 MAPK3 MAPK6 NLK	2.09e-17	379	190	29	IPR017441
Domain	Ribosomal_S6_kinase_II	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4	6.15e-10	6	190	5	IPR016239
Domain	AGC-kinase_C	RPS6KA5 RPS6KA2 RPS6KA3 MAST4 RPS6KA6 RPS6KA4 GRK1 MASTL PKN1	4.84e-09	56	190	9	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA5 RPS6KA2 RPS6KA3 MAST4 RPS6KA6 RPS6KA4 GRK1 MASTL PKN1	4.84e-09	56	190	9	PS51285
Domain	S_TK_X	RPS6KA5 RPS6KA2 RPS6KA3 MAST4 RPS6KA6 RPS6KA4 GRK1 MASTL PKN1	4.84e-09	56	190	9	SM00133
Domain	ARM-type_fold	IFT172 LRRK2 LYST PIK3CG NBEAL2 MMS19 DNAJC13 COPG1 COPG2 ARMCX5 MEI1 PPP4R3A PPP4R3B ELMO2 MROH2B ATM CTNNB1 TNPO3	1.22e-08	339	190	18	IPR016024
Domain	ARM-like	LRRK2 NBEAL2 MMS19 DNAJC13 COPG1 COPG2 ARMCX5 MEI1 PPP4R3A PPP4R3B ELMO2 MROH2B CTNNB1 TNPO3	7.23e-07	270	190	14	IPR011989
Domain	Pkinase_C	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 PKN1	1.83e-06	37	190	6	IPR017892
Domain	Pkinase_C	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 PKN1	3.96e-06	42	190	6	PF00433
Domain	MAPK	MAPK12 MAPK14 MAPK3 NLK	4.82e-06	12	190	4	PS01351
Domain	MAP_kinase_CS	MAPK12 MAPK14 MAPK3 NLK	4.82e-06	12	190	4	IPR003527
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B FNTB ELMO2	2.84e-05	18	190	4	IPR008930
Domain	TPR_REGION	IFT172 GTF3C3 TOMM70 TTC13 ZMYND12 INTS8 FEM1B TTC17 GPSM1	4.94e-05	165	190	9	PS50293
Domain	TPR	IFT172 GTF3C3 TOMM70 TTC13 ZMYND12 INTS8 FEM1B TTC17 GPSM1	4.94e-05	165	190	9	PS50005
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	PLK2 PSKH1 DAPK3 PLK3 CAMKK1 CAMK1	7.21e-05	69	190	6	IPR020636
Domain	-	LRRK2 MMS19 DNAJC13 COPG1 COPG2 ARMCX5 ELMO2 MROH2B CTNNB1 TNPO3	9.50e-05	222	190	10	1.25.10.10
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.03e-04	2	190	2	IPR032154
Domain	SMK-1	PPP4R3A PPP4R3B	1.03e-04	2	190	2	PF04802
Domain	-	COPG1 COPG2	1.03e-04	2	190	2	2.60.40.1480
Domain	COP-gamma_platf	COPG1 COPG2	1.03e-04	2	190	2	PF08752
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.03e-04	2	190	2	PF16381
Domain	Coatomer_gsu_app_Ig-like-sub	COPG1 COPG2	1.03e-04	2	190	2	IPR013040
Domain	Coatomer_gsu	COPG1 COPG2	1.03e-04	2	190	2	IPR017106
Domain	DUF625	PPP4R3A PPP4R3B	1.03e-04	2	190	2	IPR006887
Domain	TPR_2	GTF3C3 TOMM70 TTC13 TTC17 GPSM1	1.51e-04	50	190	5	PF07719
Domain	TPR_2	GTF3C3 TOMM70 TTC13 TTC17 GPSM1	1.51e-04	50	190	5	IPR013105
Domain	POLO_box_2	PLK2 PLK3	3.07e-04	3	190	2	IPR033695
Domain	TRAM1	TRAM1L1 TRAM1	3.07e-04	3	190	2	PF08390
Domain	Translocation_assoc_membrane	TRAM1L1 TRAM1	3.07e-04	3	190	2	IPR016447
Domain	TRAM1	TRAM1L1 TRAM1	3.07e-04	3	190	2	IPR013599
Domain	PH_dom-like	MYO10 PDPK1 LYST AFAP1L2 NBEAL2 ARAP2 RASGRF2 FRMPD2 PPP4R3A PPP4R3B GTF2H1 ELMO2 AKAP13	4.36e-04	426	190	13	IPR011993
Domain	TLC	TRAM1L1 TRAM1 CERS1	5.26e-04	16	190	3	SM00724
Domain	TLC	TRAM1L1 TRAM1 CERS1	5.26e-04	16	190	3	PS50922
Domain	TRAM_LAG1_CLN8	TRAM1L1 TRAM1 CERS1	5.26e-04	16	190	3	PF03798
Domain	TLC-dom	TRAM1L1 TRAM1 CERS1	5.26e-04	16	190	3	IPR006634
Domain	CTF_NFI	NFIA NFIX	6.09e-04	4	190	2	PF00859
Domain	CTF_NFI_1	NFIA NFIX	6.09e-04	4	190	2	PS00349
Domain	-	PLK2 PLK3	6.09e-04	4	190	2	3.30.1120.30
Domain	CTF_NFI_2	NFIA NFIX	6.09e-04	4	190	2	PS51080
Domain	POLO_box	PLK2 PLK3	6.09e-04	4	190	2	PF00659
Domain	POLO_box_1	PLK2 PLK3	6.09e-04	4	190	2	IPR033701
Domain	CTF/NFI_DNA-bd-dom	NFIA NFIX	6.09e-04	4	190	2	IPR020604
Domain	Clathrin_a/coatomer_app_sub_C	COPG1 COPG2	6.09e-04	4	190	2	IPR015873
Domain	NfI_DNAbd_pre-N	NFIA NFIX	6.09e-04	4	190	2	PF10524
Domain	CTF/NFI	NFIA NFIX	6.09e-04	4	190	2	IPR000647
Domain	MAPK_p38	MAPK12 MAPK14	6.09e-04	4	190	2	IPR008352
Domain	POLO_BOX	PLK2 PLK3	6.09e-04	4	190	2	PS50078
Domain	CTF/NFI_DNA-bd_N	NFIA NFIX	6.09e-04	4	190	2	IPR019548
Domain	CTF/NFI_DNA-bd_CS	NFIA NFIX	6.09e-04	4	190	2	IPR019739
Domain	-	COPG1 COPG2	6.09e-04	4	190	2	3.30.310.30
Domain	TPR-like_helical_dom	IFT172 GTF3C3 TOMM70 TTC13 ZMYND12 INTS8 VPS41 TTC17 GPSM1	6.53e-04	233	190	9	IPR011990
Domain	Anaphylatoxin_comp_syst	C4A C4B	1.01e-03	5	190	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	1.01e-03	5	190	2	IPR001840
Domain	POLO_box_dom	PLK2 PLK3	1.01e-03	5	190	2	IPR000959
Domain	-	GTF3C3 TOMM70 TTC13 ZMYND12 INTS8 VPS41 TTC17 GPSM1	1.29e-03	207	190	8	1.25.40.10
Domain	PH_BEACH	LYST NBEAL2	1.50e-03	6	190	2	PF14844
Domain	TPR_8	GTF3C3 TOMM70 TTC13 TTC17	2.06e-03	53	190	4	PF13181
Domain	ANATO	C4A C4B	2.09e-03	7	190	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	2.09e-03	7	190	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	2.09e-03	7	190	2	PS01177
Domain	ANATO	C4A C4B	2.09e-03	7	190	2	PF01821
Domain	Ski_Sno	DACH1 DACH2	2.09e-03	7	190	2	PF02437
Domain	-	DACH1 DACH2	2.09e-03	7	190	2	3.10.260.20
Domain	Transform_Ski	DACH1 DACH2	2.09e-03	7	190	2	IPR003380
Domain	Anaphylatoxin/fibulin	C4A C4B	2.09e-03	7	190	2	IPR000020
Domain	TPR_1	GTF3C3 TOMM70 TTC13 TTC17 GPSM1	2.26e-03	90	190	5	IPR001440
Domain	TPR_1	GTF3C3 TOMM70 TTC13 TTC17 GPSM1	2.26e-03	90	190	5	PF00515
Domain	-	MYO10 PDPK1 AFAP1L2 ARAP2 RASGRF2 FRMPD2 PPP4R3A PPP4R3B GTF2H1 ELMO2 AKAP13	2.27e-03	391	190	11	2.30.29.30
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	2.77e-03	8	190	2	IPR019565
Domain	PH-BEACH_dom	LYST NBEAL2	2.77e-03	8	190	2	IPR023362
Domain	Coatomer/calthrin_app_sub_C	COPG1 COPG2	2.77e-03	8	190	2	IPR009028
Domain	-	LYST NBEAL2	2.77e-03	8	190	2	2.30.29.40
Domain	Thiol-ester_cl	C4A C4B	2.77e-03	8	190	2	PF10569
Domain	PH_BEACH	LYST NBEAL2	2.77e-03	8	190	2	PS51783
Domain	MacrogloblnA2_CS	C4A C4B	2.77e-03	8	190	2	IPR019742
Domain	BEACH	LYST NBEAL2	3.54e-03	9	190	2	PS50197
Domain	Beach	LYST NBEAL2	3.54e-03	9	190	2	PF02138
Domain	-	LYST NBEAL2	3.54e-03	9	190	2	1.10.1540.10
Domain	Beach	LYST NBEAL2	3.54e-03	9	190	2	SM01026
Domain	BEACH_dom	LYST NBEAL2	3.54e-03	9	190	2	IPR000409
Domain	TPR-contain_dom	GTF3C3 TOMM70 TTC13 ZMYND12 TTC17 GPSM1	4.37e-03	150	190	6	IPR013026
Domain	An_peroxidase	DUOX1 PXDNL	4.39e-03	10	190	2	PF03098
Domain	A2M	C4A C4B	4.39e-03	10	190	2	PF00207
Domain	A2M_N_2	C4A C4B	4.39e-03	10	190	2	IPR011625
Domain	A2M_comp	C4A C4B	4.39e-03	10	190	2	IPR011626
Domain	Haem_peroxidase_animal	DUOX1 PXDNL	4.39e-03	10	190	2	IPR019791
Domain	A2M_recep	C4A C4B	4.39e-03	10	190	2	PF07677
Domain	A2M_comp	C4A C4B	4.39e-03	10	190	2	PF07678
Domain	A2M_N	C4A C4B	4.39e-03	10	190	2	PF01835
Domain	A2M_N	C4A C4B	4.39e-03	10	190	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	4.39e-03	10	190	2	IPR009048
Domain	Haem_peroxidase	DUOX1 PXDNL	4.39e-03	10	190	2	IPR010255
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK12 MAP4K4 RPS6KA4 MAPK14 MAP4K1 MAPK3 MAPK6	3.01e-10	76	145	11	MM1433
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK12 MAP4K4 RPS6KA4 MAPK14 MAP4K1 MAPK3 MAPK6	6.09e-10	81	145	11	M13863
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 MAPK12 PIK3CG RPS6KA6 MAP4K4 RPS6KA4 MAPK14 MAP4K1 MAPK3 MAPK6	9.48e-10	132	145	13	M39338
Pathway	WP_INSULIN_SIGNALING	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 MAPK12 PIK3CG RPS6KA6 MAP4K4 RPS6KA4 PDPK2P MAPK14 MAP4K1 MAPK3 MAPK6	1.00e-09	160	145	14	MM15956
Pathway	REACTOME_RSK_ACTIVATION	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 MAPK3	2.22e-09	7	145	5	M27369
Pathway	WP_INSULIN_SIGNALING	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 MAPK12 PIK3CG RPS6KA6 MAP4K4 RPS6KA4 MAPK14 MAP4K1 MAPK3 MAPK6	1.01e-08	160	145	13	M39482
Pathway	KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING	RPS6KA2 RPS6KA3 RPS6KA6 MAPK3	1.59e-07	6	145	4	M47936
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	RPS6KA2 RPS6KA3 RPS6KA6 CAMKK1 CAMK1	2.97e-07	15	145	5	MM15103
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 RASGRF2 MAPK3	3.34e-07	28	145	6	M837
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 MAPK12 PIK3CG RPS6KA6 RPS6KA4 MAPK14 MAPK3	6.76e-07	126	145	10	M16763
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	1.11e-06	19	145	5	MM14780
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	2.46e-06	22	145	5	M13408
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	RPS6KA2 RPS6KA3 MAPK12 PIK3CG BUB1 RPS6KA6 MAPK14 MAPK3	2.55e-06	85	145	8	M3578
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK12 RPS6KA6 MAP4K4 RPS6KA4 RASGRF2 MAPK14 MAP4K1 MAPK3 NLK	3.77e-06	267	145	13	M10792
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 CAMKK1 RASGRF2 CAMK1 MAPK3	5.45e-06	94	145	8	M2843
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	RPS6KA5 RPS6KA2 PIK3CG RPS6KA4 MAPK14 MAPK3	7.13e-06	46	145	6	M39805
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	7.23e-06	27	145	5	MM14779
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	8.73e-06	28	145	5	MM15132
Pathway	WP_MAPK_SIGNALING	RPS6KA5 RPS6KA3 LRRK2 CHUK MAPK12 MAP4K4 RPS6KA4 RASGRF2 MAPK14 MAP4K1 MAPK3 NLK	8.87e-06	246	145	12	M39597
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA2 RPS6KA3 RPS6KA6	1.05e-05	5	145	3	MM15108
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	1.47e-05	31	145	5	M15195
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	PDPK1 RPS6KA2 RPS6KA3 PIK3CG RPS6KA6 MAPK3	1.47e-05	52	145	6	M7561
Pathway	WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING	ACACA RPS6KA5 PDPK1 RPS6KA3 RPS6KA4 MAPK14 CTNNB1 MAPK3	1.53e-05	108	145	8	M48078
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK12 MAPK14 MAPK3	2.08e-05	6	145	3	M47766
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA2 RPS6KA3 RPS6KA6 CAMKK1 CAMK1	2.72e-05	35	145	5	MM15109
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 MAPK3	3.07e-05	59	145	6	MM15128
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	RPS6KA2 RPS6KA3 MAPK12 MAPK14 MAPK3	3.13e-05	36	145	5	M39908
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA5 RPS6KA2 RPS6KA3	3.62e-05	7	145	3	M27096
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA5 RPS6KA2 RPS6KA3	3.62e-05	7	145	3	MM14784
Pathway	WP_MAPK_SIGNALING_PATHWAY	RPS6KA3 MAPK12 MAP4K4 RASGRF2 MAPK14 MAP4K1 MAPK3 MAPK6 NLK	4.06e-05	160	145	9	MM15990
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	RPS6KA5 RPS6KA2 RPS6KA3 TLR6 CHUK MAPK14 SLC15A4 TLR3 MAPK3	6.51e-05	170	145	9	M7494
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	PDPK1 CHUK PIK3CG PDPK2P MAPK14 CTNNB1 MAPK3	7.12e-05	99	145	7	MM15905
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 SLC15A4 MAPK3	7.12e-05	99	145	7	MM14660
Pathway	BIOCARTA_EIF4_PATHWAY	PDPK1 PDPK2P MAPK14 MAPK3	8.17e-05	23	145	4	MM1470
Pathway	KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	TLR6 CHUK MAPK12 PIK3CG MAPK14 TLR3 MAPK3	8.61e-05	102	145	7	M3261
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 MAPK3	8.82e-05	71	145	6	M27382
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	TLR6 CHUK MAPK12 PIK3CG MAPK14 TLR3 MAPK3	9.16e-05	103	145	7	M39434
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	RPS6KA5 PDPK1 RPS6KA3 CHUK CAMK1 MAPK14 CTNNB1 MAPK3	1.20e-04	144	145	8	M39691
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 SLC15A4 MAPK3	1.31e-04	109	145	7	M27012
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4	1.42e-04	49	145	5	M891
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE	RPS6KA5 RPS6KA2 RPS6KA3 TLR6 CHUK MAPK14 MAPK3	1.83e-04	115	145	7	M27013
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	RPS6KA5 RPS6KA2 RPS6KA3 TLR6 CHUK MAPK14 SLC15A4 MAPK3	1.99e-04	155	145	8	MM14665
Pathway	REACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 MAPK3	2.40e-04	85	145	6	MM14645
Pathway	WP_CARDIAC_HYPERTROPHIC_RESPONSE	PDPK1 CHUK MAPK14 MAP4K1 MAPK3	2.47e-04	55	145	5	M39685
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	CHUK PIK3CG MAPK14 MAPK3	3.48e-04	33	145	4	M39745
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	4.02e-04	61	145	5	M152
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	4.68e-04	63	145	5	MM14714
Pathway	PID_BCR_5PATHWAY	PDPK1 CHUK MAPK14 MAP4K1 MAPK3	4.68e-04	63	145	5	M10
Pathway	WP_B_CELL_RECEPTOR_SIGNALING	PDPK1 CHUK PIK3CG PIP5K1C MAPK14 MAP4K1	4.89e-04	97	145	6	M39323
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA2 RPS6KA3 MAPK3	5.41e-04	16	145	3	MM15477
Pathway	WP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY	RPS6KA5 PDPK1 MAPK14 MAPK3	5.45e-04	37	145	4	M42558
Pathway	BIOCARTA_HCMV_PATHWAY	PIK3CG MAPK14 MAPK3	6.52e-04	17	145	3	M8353
Pathway	BIOCARTA_HCMV_PATHWAY	PIK3CG MAPK14 MAPK3	6.52e-04	17	145	3	MM1408
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	CHUK MAPK12 MAPK14 CTNNB1 MAPK3	6.66e-04	68	145	5	M39456
Pathway	REACTOME_SIGNALING_BY_VEGF	PDPK1 MAPK12 PDPK2P MAPK14 ELMO2 CTNNB1	6.73e-04	103	145	6	MM14752
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	PDPK1 CHUK PIK3CG MAPK14 CTNNB1 MAPK3	7.08e-04	104	145	6	M39625
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	ABCA1 CHUK MAPK14 CTNNB1 MAPK3	7.12e-04	69	145	5	M48052
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA2 RPS6KA3 MAPK3	7.77e-04	18	145	3	M657
Pathway	BIOCARTA_PTEN_PATHWAY	PDPK1 PDPK2P MAPK3	7.77e-04	18	145	3	MM1461
Pathway	KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	PDPK1 CHUK MAPK12 PIK3CG MAPK14 MAPK3	8.64e-04	108	145	6	M9904
Pathway	WP_TNFRELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING	CHUK MAPK14 CTNNB1 MAPK3	8.87e-04	42	145	4	M39452
Pathway	REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 MAPK3	9.07e-04	109	145	6	M29565
Pathway	REACTOME_SIGNALING_BY_NTRKS	RPS6KA5 RPS6KA2 RPS6KA3 MAPK14 MAPK3	1.04e-03	75	145	5	MM14652
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	PDPK1 PIK3CG PDPK2P	1.07e-03	20	145	3	MM15867
Pathway	BIOCARTA_CREB_PATHWAY	RPS6KA5 MAPK14 MAPK3	1.07e-03	20	145	3	MM1520
Pathway	KEGG_OOCYTE_MEIOSIS	RPS6KA2 RPS6KA3 MAPK12 BUB1 RPS6KA6 MAPK3	1.09e-03	113	145	6	M16817
Pathway	REACTOME_NEURONAL_SYSTEM	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 KCNN3 KCNS3 CAMKK1 RASGRF2 CAMK1 SLC6A4 LRRTM2 MAPK3	1.10e-03	411	145	12	M735
Pathway	BIOCARTA_RAS_PATHWAY	CHUK PIK3CG MAPK3	1.24e-03	21	145	3	MM1464
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 CAMKK1 RASGRF2 CAMK1 MAPK3	1.27e-03	205	145	8	M752
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	PDPK1 MAPK12 PIK3CG MAPK14 MAPK3	1.31e-03	79	145	5	M11816
Pathway	WP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE	MAPK12 BUB1 MAPK14 ATM	1.36e-03	47	145	4	M39518
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	MAPK12 PIK3CG MAPK14 CTNNB1 MAPK3 MAPK6	1.37e-03	118	145	6	M39852
Pathway	BIOCARTA_CREB_PATHWAY	RPS6KA5 MAPK14 MAPK3	1.42e-03	22	145	3	M9070
Pathway	BIOCARTA_AKT_PATHWAY	PDPK1 CHUK PIK3CG	1.42e-03	22	145	3	M15258
Pathway	BIOCARTA_GSK3_PATHWAY	PDPK1 PDPK2P CTNNB1	1.42e-03	22	145	3	MM1421
Pathway	BIOCARTA_RAS_PATHWAY	CHUK PIK3CG MAPK3	1.42e-03	22	145	3	M17294
Pathway	REACTOME_CELLULAR_SENESCENCE	RPS6KA2 RPS6KA3 MAP4K4 MAPK14 ATM MAPK3	1.43e-03	119	145	6	MM14901
Pathway	REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ	PDPK1 PDPK2P	1.53e-03	6	145	2	MM15665
Pathway	REACTOME_ACTIVATION_OF_RAC1_DOWNSTREAM_OF_NMDARS	CAMKK1 CAMK1	1.53e-03	6	145	2	MM15662
Pathway	REACTOME_SLC15A4_TASL_DEPENDENT_IRF5_ACTIVATION	CHUK SLC15A4	1.53e-03	6	145	2	M48272
Pathway	REACTOME_SLC15A4_TASL_DEPENDENT_IRF5_ACTIVATION	CHUK SLC15A4	1.53e-03	6	145	2	MM17244
Pathway	REACTOME_L1CAM_INTERACTIONS	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 MAPK3	1.56e-03	121	145	6	M872
Pathway	WP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY	RPS6KA5 CHUK MAPK14 MAPK3	1.59e-03	49	145	4	M39543
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING	MAPK12 GCLC MAPK14	1.62e-03	23	145	3	M39709
Pathway	WP_SIGNAL_TRANSDUCTION_OF_S1P_RECEPTOR	MAPK12 MAPK3 MAPK6	1.62e-03	23	145	3	MM15952
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PKNS	PDPK1 PDPK2P PKN1	1.62e-03	23	145	3	MM15216
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK14 MAPK3	1.62e-03	122	145	6	MM14640
Pathway	PID_TOLL_ENDOGENOUS_PATHWAY	TLR6 CHUK TLR3	1.84e-03	24	145	3	M264
Pathway	REACTOME_MYOGENESIS	MAPK12 MAPK14 CTNNB1	1.84e-03	24	145	3	MM15174
Pathway	KEGG_MEDICUS_REFERENCE_TNF_P38_SIGNALING_PATHWAY	RPS6KA5 RPS6KA4 MAPK14	1.84e-03	24	145	3	M47568
Pathway	BIOCARTA_EIF4_PATHWAY	PDPK1 MAPK14 MAPK3	1.84e-03	24	145	3	M4791
Pathway	BIOCARTA_TFF_PATHWAY	PIK3CG CTNNB1 MAPK3	1.84e-03	24	145	3	M15926
Pathway	BIOCARTA_NFAT_PATHWAY	PIK3CG CAMK1 MAPK14 MAPK3	1.84e-03	51	145	4	M2288
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	PDPK1 RPS6KA2 RPS6KA3 MAPK3	1.84e-03	51	145	4	M7955
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	PDPK1 RPS6KA2 RPS6KA3 RPS6KA6 CAMKK1 RASGRF2 CAMK1 SLC6A4 MAPK3	1.91e-03	270	145	9	M15514
Pathway	KEGG_ENDOMETRIAL_CANCER	PDPK1 PIK3CG CTNNB1 MAPK3	1.98e-03	52	145	4	M19877
Pathway	BIOCARTA_HDAC_PATHWAY	PIK3CG CAMK1 MAPK14	2.08e-03	25	145	3	M1547
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	MAPK12 MAPK3 MAPK6	2.08e-03	25	145	3	M39384
Pathway	BIOCARTA_TOLL_PATHWAY	CHUK MAPK14 TLR3	2.08e-03	25	145	3	M984
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE	ZNF420 ATM	2.13e-03	7	145	2	MM15333
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PALD1 MAN2A2 ACACA UBE4B MYO10 RPS6KA2 ATG2A STK11IP LYST TPCN1 TBC1D16 TLK1 MDN1 NBEAL2 SLC35A2 TIGD3 DOCK6 PLK3 MPP3 FNTB STK32C PIP5K1C ZNF865 ANO8 RPAP1 AKAP13 PKN1 TNPO3	3.29e-11	1105	196	28	35748872
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	GAPVD1 IFT172 RPS6KA3 TOMM70 DUSP23 TTC13 ASCC3 QSOX2 MPP3 EXOSC10 EPM2A COPG1 FNTB QTRT2 PREPL DICER1 ERLIN1 PPP4R3A SLC6A4 PTPDC1 MAPK14 RPAP1 TTC17 MAPK3 GPSM1 TNPO3	5.79e-11	974	196	26	28675297
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA4 MAPK14 MAPK3	8.58e-11	14	196	6	9687510
Pubmed	Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.	RPS6KA5 PDPK1 RPS6KA4 PDPK2P MAPK14	6.68e-10	9	196	5	23979601
Pubmed	Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.	PDPK1 RPS6KA3 RPS6KA6 PDPK2P	9.78e-10	4	196	4	12711546
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	GAPVD1 RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 DAPK3 LYST CHUK BUB1 MAP4K4 RPS6KA4 CAMKK1 AAK1 DICER1 GTF2H1 MAPK14 MAP4K1 PKN1 ANKRD36 CTNNB1 MAPK3 MAPK6	1.16e-08	910	196	22	36736316
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA2 RPS6KA3 RPS6KA6 MAPK3	1.45e-08	6	196	4	12832467
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	RPS6KA2 RPS6KA3 MAP4K4 RPS6KA4 MAPK14 MAP4K1 PKN1 MAPK3	1.48e-08	78	196	8	17192257
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PLK2 GAPVD1 ACACA RPS6KA2 DAPK3 LYST NEK4 MDN1 MAST4 DOCK6 MAP4K4 ARAP2 CAMKK1 AAK1 STK32C ELMO2 MAP4K1 AKAP13 SRPK3 TRAPPC14 TNPO3	2.19e-08	861	196	21	36931259
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RPS6KA5 PSKH1 RPS6KA2 RPS6KA3 DAPK3 RPS6KA6 KCNS3 MAP4K4 CAMKK1 STK32C MAP4K1 VPS41 SRPK3 PKN1	3.06e-08	372	196	14	22939624
Pubmed	Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1.	PDPK1 PDPK2P CTNNB1	1.76e-07	3	196	3	14500370
Pubmed	PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.	PDPK1 RPS6KA3 PDPK2P	1.76e-07	3	196	3	28314444
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MAN2A2 GTF3C3 TPCN1 HSPA13 NEK4 CSGALNACT2 SLC35A2 SEMA3B C4A TTC13 QSOX2 NPR3 GNPTAB ERLIN1 SLC30A7 TRAM1 DPY19L4 UGGT2 TTC17 ATM SELENOI CTNNB1 CERS1	3.50e-07	1201	196	23	35696571
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GAPVD1 ACACA RPS6KA5 UBE4B PDPK1 TLK1 MDN1 NFIA MAP4K4 DNAJC13 AAK1 BAZ1B PPP4R3A RPAP1 MAP4K1 PKN1 ATM MAPK3	4.68e-07	774	196	18	15302935
Pubmed	The protein interaction landscape of the human CMGC kinase group.	PDPK1 RPS6KA2 RPS6KA3 CHUK MAPK12 MPP3 RPS6KA4 FNTB CAMK1 GTF2H1 MAPK14 SRPK3 CTNNB1 MAPK3 MAPK6 TNPO3 NLK	4.94e-07	695	196	17	23602568
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PALD1 UBE4B MYO10 IFT172 URB2 TOMM70 ARAP2 PIP5K1C FHIP2A FEM1B RPAP1 LRRTM2 SELENOI	6.23e-07	407	196	13	12693553
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	COG3 STK11IP HSPA13 TOMM70 MDN1 GCLC SLC35A2 ATP11C DOCK6 QSOX2 COPG2 INTS8 DICER1 ELMO2 SLC15A4 NR5A2 VPS41 DPY19L4 UGGT2 PKN1 ATM	6.94e-07	1061	196	21	33845483
Pubmed	The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.	RPS6KA5 CHUK RPS6KA4	7.02e-07	4	196	3	24519526
Pubmed	Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.	RPS6KA5 RPS6KA4 MAPK14	7.02e-07	4	196	3	25233930
Pubmed	gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.	MAPK12 MAPK14 MAPK3 MAPK6	9.37e-07	14	196	4	12239168
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TRPM6 PLK2 RPS6KA5 RPS6KA2 RPS6KA3 TLK1 MAPK12 SEMA3B RPS6KA6 PLK3 RPS6KA4 PIP5K1C GRK1 MAPK14 MAP4K1 MAPK3 MAPK6	9.69e-07	730	196	17	34857952
Pubmed	Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.	PDPK1 RPS6KA2 RPS6KA3 PDPK2P	1.27e-06	15	196	4	27644329
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	GALE PSKH1 RPS6KA3 ZNF813 PXDNL NBEAL2 SLC35A2 RPS6KA6 ASCC3 PLK3 QSOX2 RDH12 PIP5K1C DACH2 CCDC82 MAP4K1 MASTL TRAPPC14	1.31e-06	832	196	18	36724073
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 CHUK MAPK12 PIK3CG BUB1 MAPK14 CTNNB1 MAPK3 NLK	1.49e-06	371	196	12	25241761
Pubmed	RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.	PDPK1 PDPK2P MAPK14 MAPK3	1.69e-06	16	196	4	16217033
Pubmed	Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.	PDPK1 PDPK2P CTNNB1	1.75e-06	5	196	3	21705713
Pubmed	The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.	RPS6KA2 RPS6KA3 RPS6KA6	1.75e-06	5	196	3	37068088
Pubmed	The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.	PDPK1 RPS6KA3 PDPK2P	1.75e-06	5	196	3	26401001
Pubmed	Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.	PDPK1 PDPK2P PKN1	1.75e-06	5	196	3	12783890
Pubmed	Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.	RPS6KA2 RPS6KA3 RPS6KA6	1.75e-06	5	196	3	11160957
Pubmed	90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.	PDPK1 RPS6KA2 RPS6KA3	1.75e-06	5	196	3	10480933
Pubmed	RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).	RPS6KA4 MAPK14 MAPK3	1.75e-06	5	196	3	9792677
Pubmed	Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.	PSKH1 RPS6KA2 RPS6KA3	1.75e-06	5	196	3	15526037
Pubmed	RSK2 is a modulator of craniofacial development.	RPS6KA2 RPS6KA3 RPS6KA6	1.75e-06	5	196	3	24416220
Pubmed	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.	RPS6KA2 RPS6KA3 MAPK3	1.75e-06	5	196	3	9915826
Pubmed	The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.	RPS6KA5 RPS6KA3 RPS6KA4	1.75e-06	5	196	3	17906627
Pubmed	Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling.	MAPK14 PDE5A MAPK3	1.75e-06	5	196	3	18641057
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	GAPVD1 UBE4B URB2 GTF3C3 TOMM70 MMS19 TTC13 ASCC3 QSOX2 NUP107 COPG1 COPG2 INTS8 ERLIN1 RPAP1 UGGT2 CTNNB1 CERS1 TNPO3	1.84e-06	942	196	19	31073040
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ACACA MMS19 ASCC3 DOCK6 DNAJC13 NUP107 DICER1 AKAP13 TTC17	2.41e-06	202	196	9	33005030
Pubmed	Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells.	RPS6KA5 MAPK14 MAPK3	3.48e-06	6	196	3	15192015
Pubmed	IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.	CHUK PIK3CG MAPK3	3.48e-06	6	196	3	20671123
Pubmed	Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.	RPS6KA2 RPS6KA3 RPS6KA4	3.48e-06	6	196	3	8688081
Pubmed	ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.	RPS6KA2 CHUK ATM	3.48e-06	6	196	3	14966265
Pubmed	NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.	RPS6KA2 RPS6KA3 RPS6KA4	3.48e-06	6	196	3	11175347
Pubmed	Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.	RPS6KA2 RPS6KA3 MAPK3	3.48e-06	6	196	3	8939914
Pubmed	The MAP kinase ERK5 binds to and phosphorylates p90 RSK.	RPS6KA2 RPS6KA3 MAPK3	3.48e-06	6	196	3	16626623
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	GAPVD1 ACACA IFT172 GTF3C3 MDN1 ASCC3 RAD21 EXOSC10 DNAJC13 NUP107 COPG1 COPG2 PPP4R3A CTNNB1 TNPO3	3.84e-06	638	196	15	33239621
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CADM3 PLK2 GAPVD1 UBE4B ZNF813 URB2 GTF3C3 QSOX2 DNAJC13 NUP107 BAZ1B INTS8 ERLIN1 SLC30A7 RLF PPP4R3B ZNF525 ZNF420 CTNNB1 TNPO3 NLK	4.96e-06	1203	196	21	29180619
Pubmed	The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.	PLK2 PLK3 MAPK14	6.07e-06	7	196	3	10557092
Pubmed	Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.	RPS6KA3 MAPK14 ATM	6.07e-06	7	196	3	12562765
Pubmed	Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.	RPS6KA5 RPS6KA3 MAPK14	6.07e-06	7	196	3	11157753
Pubmed	In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon.	CHUK MAPK14 MAPK3	6.07e-06	7	196	3	17182689
Pubmed	Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.	RPS6KA5 RPS6KA4 MAPK3	6.07e-06	7	196	3	20018936
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	MAPK12 MAP4K4 MAPK14 CTNNB1	6.61e-06	22	196	4	16751104
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	BCKDK URB2 STK11IP TOMM70 MDN1 ASCC3 DOCK6 QSOX2 COPG1 COPG2 DICER1 SLC30A7 UGGT2 SELENOI MAPK3 TNPO3	6.62e-06	754	196	16	33060197
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PLK2 GAPVD1 MYO10 PDPK1 ATG2A GTF3C3 CHUK NEK4 NFIA DOCK6 MAP4K4 COPG1 AAK1 COPG2 FHIP2A PTPDC1 RPAP1 CTNNB1 GPSM1	7.40e-06	1038	196	19	26673895
Pubmed	MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.	RPS6KA5 RPS6KA3 RPS6KA4	9.67e-06	8	196	3	12773393
Pubmed	Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.	MAPK12 MAPK14 PKN1	9.67e-06	8	196	3	12761180
Pubmed	Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function.	RPS6KA5 RPS6KA4 MAPK14	9.67e-06	8	196	3	10922375
Pubmed	HIV-1 Tat protein induces IL-10 production in monocytes by classical and alternative NF-kappaB pathways.	CHUK MAPK14 MAPK3	9.67e-06	8	196	3	18760861
Pubmed	CREB is a regulatory target for the protein kinase Akt/PKB.	RPS6KA2 RPS6KA3 RPS6KA4	9.67e-06	8	196	3	9829964
Pubmed	Bioinformatics and cellular signaling.	CHUK TOMM70 MAPK12 PIK3CG RPS6KA4 MAPK14 AKAP13 CTNNB1	9.76e-06	182	196	8	15102471
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BCKDK GTF3C3 LACTB HSPA13 MDN1 TTC13 ASCC3 MAP4K4 RAD21 EXOSC10 DNAJC13 NUP107 BAZ1B PREPL DICER1 RPAP1 TRAM1 UGGT2 AKAP13 TTC17 ATM CTNNB1 SMCR8	1.23e-05	1487	196	23	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ACACA UBE4B RPS6KA2 COG3 TLK1 NFIA NFIX SEMA3B DOCK6 DNAJC13 FRMPD2 AAK1 STK32C INTS8 ANO8 RLF PTPDC1 VPS41 AKAP13 PKN1 TTC17 MAPK6 NLK	1.25e-05	1489	196	23	28611215
Pubmed	DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.	MAPK14 PKN1 CTNNB1 MAPK3	1.33e-05	26	196	4	26526197
Pubmed	The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival.	PDPK1 PDPK2P MAPK14 MAPK3	1.33e-05	26	196	4	20685850
Pubmed	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	ABCA1 CETP IFT172 DOCK6 BAZ1B	1.37e-05	54	196	5	23505323
Pubmed	RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.	RPS6KA5 RPS6KA4 MAPK14	1.44e-05	9	196	3	19224920
Pubmed	Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.	RPS6KA5 RPS6KA4 MAPK14	1.44e-05	9	196	3	20362473
Pubmed	P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.	RPS6KA2 RPS6KA3 MAPK3	1.44e-05	9	196	3	19555761
Pubmed	Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis.	GCLC MAPK14 CTNNB1 MAPK3	1.55e-05	27	196	4	26199344
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	ACACA BCKDK LACTB TOMM70 GPAM	1.78e-05	57	196	5	17208939
Pubmed	A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.	PDPK1 RPS6KA2 PDPK2P	2.05e-05	10	196	3	32979304
Pubmed	MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.	MAPK12 MAPK14 MAPK3	2.05e-05	10	196	3	12223406
Pubmed	Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.	RPS6KA5 RPS6KA3 RPS6KA4	2.05e-05	10	196	3	29229781
Pubmed	Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.	MAPK14 MAPK3 MAPK6	2.05e-05	10	196	3	8444355
Pubmed	Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes.	PDPK1 PDPK2P MAPK3	2.05e-05	10	196	3	33567274
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	EPC2 ZSWIM3 ACACA UBE4B MYO10 TLK1 GCLC SLC35A2 MAP4K4 QSOX2 GNPTAB PREPL DICER1 RLF DACH2 ELMO2 NR5A2 VPS41 SELENOI MAPK6 PTGDR2	2.15e-05	1327	196	21	32694731
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TOMM70 BUB1 C4A C4B MAP4K4 QSOX2 GPAM FHIP2A DICER1 RPAP1 ELMO2 TRAM1 UGGT2 AKAP13	2.15e-05	650	196	14	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GAPVD1 ACACA URB2 GTF3C3 MDN1 ASCC3 RAD21 EXOSC10 NUP107 COPG1 BAZ1B COPG2 DICER1 ATM	2.27e-05	653	196	14	22586326
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PALD1 RPS6KA3 BCKDK COG3 CHUK TOMM70 MDN1 MMS19 ASCC3 EXOSC10 COPG1 QTRT2 COPG2 FHIP2A DICER1 ERLIN1 SLC30A7 TRAM1 ATM CTNNB1 TRAPPC14 TNPO3	2.32e-05	1440	196	22	30833792
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	PLK3 MAPK14 ATM	2.81e-05	11	196	3	11551930
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	GAPVD1 ACACA MDN1 NBEAL2 C4A C4B ASCC3 MAP4K4 RASGRF2 RAPGEF4 MEI1 ATM	2.82e-05	497	196	12	36774506
Pubmed	Discovery and refinement of loci associated with lipid levels.	ABCA1 CETP PSKH1 LACTB DOCK6 MPP3 DNAJC13 GPAM	2.83e-05	211	196	8	24097068
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	UBE4B MDN1 COPG1 COPG2 AKAP13 ATM	2.85e-05	104	196	6	31240132
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	RPS6KA2 BCKDK DAPK3 MAPK12 PIK3CG RPS6KA4 MAP4K1 ATM MAPK3	2.94e-05	276	196	9	28319085
Pubmed	Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.	PDPK1 PDPK2P	3.16e-05	2	196	2	19716369
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	3.16e-05	2	196	2	19062096
Pubmed	Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.	PDPK1 PDPK2P	3.16e-05	2	196	2	17077298
Pubmed	3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.	PDPK1 PDPK2P	3.16e-05	2	196	2	17077284
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	3.16e-05	2	196	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	3.16e-05	2	196	2	12207352
Pubmed	The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.	RPS6KA5 RPS6KA4	3.16e-05	2	196	2	21166721
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	3.16e-05	2	196	2	27758680
Pubmed	Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.	PDPK1 PDPK2P	3.16e-05	2	196	2	21063107
Pubmed	Conditional knockout of the PDK-1 gene in osteoblasts affects osteoblast differentiation and bone formation.	PDPK1 PDPK2P	3.16e-05	2	196	2	33377210
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	3.16e-05	2	196	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	3.16e-05	2	196	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	3.16e-05	2	196	2	4216347
Pubmed	Essential role of PDK1 in regulating endothelial cell migration.	PDPK1 PDPK2P	3.16e-05	2	196	2	17371830
Interaction	EEF1AKMT3 interactions	GAPVD1 RPS6KA5 RPS6KA2 RPS6KA3 CHUK MDN1 NBEAL2 ASCC3 DOCK6 RPS6KA4 CAMK1 ARMCX5 RNF123 MAPK14 RPAP1 VPS41 GPSM1	6.90e-08	364	190	17	int:EEF1AKMT3
Interaction	STIP1 interactions	GAPVD1 ACACA IFT172 RPS6KA3 BCKDK LRRK2 GTF3C3 MDN1 ASCC3 RAD21 ANKK1 EXOSC10 EPM2A DNAJC13 NUP107 COPG1 COPG2 STK32C PPP4R3A LRRC9 SLC6A4 RNF123 MAP4K1 CTNNB1 MAPK6 TNPO3	2.97e-06	1006	190	26	int:STIP1
Interaction	CREB1 interactions	RPS6KA5 RPS6KA2 RPS6KA3 DACH1 CSGALNACT2 NFIA NFIX RPS6KA4 MAPK14 NR5A2 ATM CTNNB1	5.54e-06	254	190	12	int:CREB1
Interaction	FKBP5 interactions	PSKH1 BCKDK URB2 CHUK NEK4 TOMM70 MAPK12 BUB1 ANKK1 EPM2A RPS6KA4 ARMCX5 DICER1 MAP4K1 MAPK3	9.53e-06	414	190	15	int:FKBP5
Interaction	RPS6KA1 interactions	ACACA RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 RAD21 RPS6KA4 COPG1 MASTL ATM MAPK3	1.13e-05	228	190	11	int:RPS6KA1
Interaction	MAPK3 interactions	GALE RPS6KA5 UBE4B RPS6KA2 RPS6KA3 LRRK2 TLK1 BUB1 RPS6KA6 RPS6KA4 SLC6A4 PTPDC1 MAPK14 MAPK3 ZDHHC11	1.16e-05	421	190	15	int:MAPK3
Interaction	HSP90AA1 interactions	GALE RPS6KA5 PSKH1 PDPK1 RPS6KA2 RPS6KA3 BCKDK LRRK2 DAPK3 CHUK NEK4 TOMM70 RPS6KA6 KCNS3 C4A MAP4K4 RAD21 ANKK1 RPS6KA4 CAMKK1 STK32C MAPK14 MAP4K1 VPS41 SRPK3 PKN1 CTNNB1 MAPK3	2.12e-05	1263	190	28	int:HSP90AA1
Interaction	MBP interactions	RPS6KA5 LRRK2 TLK1 MAPK12 RPS6KA6 MAPK14 PKN1 MAPK3	2.62e-05	126	190	8	int:MBP
Interaction	RBKS interactions	PDPK1 RPS6KA3 NEK4 MAPK12	4.04e-05	21	190	4	int:RBKS
Interaction	ILVBL interactions	URB2 COG3 MDN1 MMS19 RPGRIP1L COPG2 STK32C MAPK6 TNPO3	6.18e-05	183	190	9	int:ILVBL
Cytoband	10q24-q25	CHUK MMS19	1.08e-04	4	196	2	10q24-q25
Cytoband	19q13.12	ZNF571 ZNF585B ZNF573 ZNF420	2.64e-04	72	196	4	19q13.12
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4	7.34e-09	11	128	5	1156
GeneFamily	Mitogen-activated protein kinases	MAPK12 MAPK14 MAPK3 MAPK6	1.63e-06	13	128	4	651
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K4 MAP4K1	4.90e-04	5	128	2	655
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	GTF3C3 TOMM70 TTC13 TTC17 GPSM1	1.36e-03	115	128	5	769
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.73e-03	9	128	2	1234
GeneFamily	WD repeat domain containing\|BEACH domain containing	LYST NBEAL2	1.73e-03	9	128	2	1230
GeneFamily	CD molecules\|Toll like receptors	TLR6 TLR3	2.16e-03	10	128	2	948
GeneFamily	TLC domain containing	TRAM1L1 TRAM1	2.16e-03	10	128	2	1374
GeneFamily	X-linked mental retardation\|RNA helicases	ASCC3 DICER1	2.62e-03	11	128	2	1168
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	UBE4B MYO10 PIK3CG MAP4K4 ARAP2 RAD21 RPGRIP1L BAZ1B ATM	8.67e-06	180	195	9	M8239
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_CD8_TCELL_90MIN_UP	TRPM6 LYST MAST4 RPS6KA6 ARAP2 MPP3 ANO8 MROH2B PTGDR2	1.18e-05	187	195	9	M9225
Coexpression	NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_UP	UBE4B TLR6 LYST CHUK MMS19 EXOSC10 EPM2A GNPTAB PREPL DICER1 UGGT2 AKAP13 TTC17 ATM	1.48e-05	477	195	14	M40930
Coexpression	GSE8685_IL2_STARVED_VS_IL2_ACT_IL2_STARVED_CD4_TCELL_UP	ABCA1 GALE DAPK3 RASGRF2 AAK1 RNF123 CCDC82 MAP4K1 AKAP13	1.93e-05	199	195	9	M324
Coexpression	GSE2770_UNTREATED_VS_ACT_CD4_TCELL_6H_DN	ABCA1 PSKH1 HACD4 MAPK12 MAST4 DOCK6 EXOSC10 CCDC82 SRPK3	2.01e-05	200	195	9	M6018
Coexpression	GSE360_L_DONOVANI_VS_L_MAJOR_DC_UP	CETP DAPK3 GNMT TOMM70 NFIA PIK3CG NPR3 DICER1 TLR3	2.01e-05	200	195	9	M5192
Coexpression	FIRESTEIN_PROLIFERATION	PIK3CG RPS6KA6 EXOSC10 RPS6KA4 AAK1 STK32C MASTL PKN1	3.60e-05	166	195	8	M5354
Coexpression	GSE21360_SECONDARY_VS_TERTIARY_MEMORY_CD8_TCELL_DN	PALD1 HACD4 TPCN1 NBEAL2 PIP5K1C MAPK14 RPAP1 MAP4K1	3.75e-05	167	195	8	M7621
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLK2 DACH1 URB2 MAPK12 MAST4 NPR3 RASGRF2 RAPGEF4 LRRTM2 NR5A2	6.36e-09	177	195	10	16197068260fc062bf8b730a51a199887ea580b9
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	URB2 DUSP23 MDN1 ATP11C ARAP2 RASGRF2 RAPGEF4 NR5A2 NLK	2.00e-07	194	195	9	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	TRPM6 MDN1 MAST4 ATP11C RASGRF2 RAPGEF4 NR5A2 AKAP13 NLK	2.38e-07	198	195	9	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	PLK2 DACH1 AFAP1L2 MAPK12 DOCK6 RASGRF2 RAPGEF4 NR5A2	8.29e-07	169	195	8	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 RPS6KA3 DACH1 LYST ASCC3 ARAP2 BAZ1B CCDC82	1.23e-06	178	195	8	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 RPS6KA2 HSPA13 TRPM5 MAST4 EPM2A PREPL PDE5A	1.23e-06	178	195	8	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 RPS6KA2 HSPA13 TRPM5 KCNN3 PREPL PDE5A UNC80	2.16e-06	192	195	8	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLK2 DACH1 MAST4 DOCK6 NPR3 RAPGEF4 DACH2 NR5A2	2.24e-06	193	195	8	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PALD1 PLK2 RPS6KA2 DACH1 DOCK6 NPR3 RAPGEF4 NR5A2	2.52e-06	196	195	8	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PLK2 RPS6KA2 DACH1 MAST4 DOCK6 NPR3 RAPGEF4 NR5A2	2.92e-06	200	195	8	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Control-Endothelial_cells-Inflamed_endothelial_cells\|Control / group, cell type (main and fine annotations)	PALD1 PLK2 DACH1 RASGRF2 RAPGEF4 SLC6A4 NR5A2	6.87e-06	160	195	7	958256e3d3836160763b82bb48f794087918d935
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	CADM3 DACH1 DOCK6 NPR3 RASGRF2 RAPGEF4 NR5A2	1.96e-05	188	195	7	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 RPS6KA2 RAPGEF4 PDE5A AKAP13 GPSM1 UNC80	1.96e-05	188	195	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PALD1 PLK2 DACH1 DOCK6 NPR3 RAPGEF4 NR5A2	2.03e-05	189	195	7	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	DACH1 DOCK6 NPR3 RASGRF2 RAPGEF4 SLC6A4 NR5A2	2.10e-05	190	195	7	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CADM3 DACH1 LYST DOCK6 NPR3 RAPGEF4 NR5A2	2.10e-05	190	195	7	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 ABCA1 CSGALNACT2 MAPK14 ELMO2 TRAM1 CTNNB1	2.10e-05	190	195	7	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	DACH1 DOCK6 NPR3 RASGRF2 RAPGEF4 SLC6A4 NR5A2	2.10e-05	190	195	7	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GALE INTS8 ZNF677 RNF123 SLC15A4 TLR3 VPS41	2.17e-05	191	195	7	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 LYST CSGALNACT2 PLIN5 NBEAL2 MAP4K4 MAPK3	2.32e-05	193	195	7	e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLK2 DACH1 DOCK6 NPR3 RAPGEF4 DACH2 NR5A2	2.32e-05	193	195	7	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)\|Adult / Lineage, Cell type, age group and donor	PALD1 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.32e-05	193	195	7	39c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 MAST4 DOCK6 NPR3 RAPGEF4 DACH2 NR5A2	2.40e-05	194	195	7	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT1 RPS6KA2 TBC1D16 TRPM5 PDE5A GPSM1 UNC80	2.48e-05	195	195	7	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PALD1 KCNN3 DOCK6 RASGRF2 RAPGEF4 NR5A2 CTNNB1	2.56e-05	196	195	7	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	Endothelial-capillary_endothelial_cell_(Cap1)\|World / Lineage, Cell type, age group and donor	PLK2 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.56e-05	196	195	7	0ce3ed27d2b9276390952652c17a8d6de13add36
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDHR5 TIGD3 RPS6KA4 LINC00158 NUDT17 SLC15A4 MAP4K1	2.64e-05	197	195	7	3a5908deb5c5a2bf06019a102fb1652233cf2a2a
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHTF8 MAP4K4 ARAP2 PPP4R3A PPP4R3B VPS41 CTNNB1	2.73e-05	198	195	7	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHTF8 MAP4K4 ARAP2 PPP4R3A PPP4R3B VPS41 CTNNB1	2.73e-05	198	195	7	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	COVID-19-lung-Capillary_2\|lung / Disease (COVID-19 only), tissue and cell type	DACH1 DOCK6 NPR3 RASGRF2 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell	343B-Endothelial_cells-Endothelial-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	PLK2 CETP DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	bff61a784ef8bc040f5c7baabccaf7a7cddd5a31
ToppCell	Bronchial-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PALD1 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	36a230b80096455df26c2e2c8c05fd6b231508c5
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PALD1 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PALD1 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	d58edc5f74970bb26d844746184e4bae7c494d6b
ToppCell	343B-Endothelial_cells-Endothelial-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	PLK2 CETP DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.82e-05	199	195	7	3cb1d9d9de64ed0a56c4f8d5e2fa02a13a73d8ac
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PLK2 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.91e-05	200	195	7	2d962c9d63e9e5f1a06870e383609672e7b1738c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PALD1 TLR6 DOCK6 MEI1 TLR3 SMCR8 NLK	2.91e-05	200	195	7	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	PLK2 RPS6KA2 DACH1 MAST4 DOCK6 RAPGEF4 NR5A2	2.91e-05	200	195	7	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PLK2 RPS6KA2 DACH1 DOCK6 NPR3 RAPGEF4 NR5A2	2.91e-05	200	195	7	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PALD1 TLR6 DOCK6 MEI1 TLR3 SMCR8 NLK	2.91e-05	200	195	7	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	PLK2 RPS6KA2 DACH1 MAST4 DOCK6 RAPGEF4 NR5A2	2.91e-05	200	195	7	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR5 PLIN5 SEMA3B SLC6A4 NR5A2 TM4SF20	4.67e-05	147	195	6	a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCell	COVID-19-APC-like-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	TLR6 PLK3 CAMK1 IDO2 RPAP1 SELENOI	6.98e-05	158	195	6	a0d94bd067424783863a48db20976d4c2043600c
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO10 NEK4 C4B GNPTAB CAMK1 UGGT2	8.01e-05	162	195	6	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RPS6KA2 CSNK1G1 GPAM ARMCX5 ZNF865 GPSM1	8.01e-05	162	195	6	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	Control-MAIT\|World / Disease group and Cell class	ABCA1 TBC1D16 DUOX1 NFIA CAMKK1 GPSM1	8.29e-05	163	195	6	0ca4b835936b4f82217cbe57210c1dd90986c1d0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFIA ATP11C KCNS3 CALN1 RASGRF2 MAPK3	8.29e-05	163	195	6	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFIX KCNN3 ATP11C KCNS3 RASGRF2 MAPK3	8.57e-05	164	195	6	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHUK TRPM5 PIK3CG NBEAL2 TTC13 CAMKK1	8.86e-05	165	195	6	34fd00be2b28716c871ad9fb356de84a299a0c01
ToppCell	367C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	ATG2A ARAP2 ANKRD36 ATM	9.82e-05	55	195	4	7916216b3a24f9c6b966aa5392fc2bc43b3d2c4c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DACH1 AFAP1L2 MAPK12 DOCK6 NPR3 RASGRF2	1.08e-04	171	195	6	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	MAP4K4 QSOX2 EXOSC10 NUP107 GTF2H1 TRAPPC14	1.11e-04	172	195	6	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	moderate-Myeloid-Mast_cell\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RPS6KA5 DACH1 NXPE2 MAST4 GNPTAB PTGDR2	1.22e-04	175	195	6	bbd2971bc6d69e507f90a637834d0936c205c590
ToppCell	NS-moderate-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PLK2 RASGRF2 RAPGEF4 SLC6A4 ELMO2 SRPK3	1.22e-04	175	195	6	a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 ABCA1 RPS6KA2 LRRK2 DACH1 CSGALNACT2	1.22e-04	175	195	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	390C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MAN2A2 STK11IP GCLC ZNF677 ZNF420 SELENOI	1.38e-04	179	195	6	3edcd1356e49b1f5514c585861999e079ca5e579
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADM3 ABCA1 HACD4 DUOX1 SEMA3B C4B	1.43e-04	180	195	6	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	RPS6KA5 LYST LACTB GNPTAB SLC15A4 CTNNB1	1.47e-04	181	195	6	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CADM3 CALN1 CAMKK1 RDH12 DACH2 UNC80	1.61e-04	184	195	6	9e5f98f9113e5e38bdadba6d9d2c346177fb35fe
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	DACH1 MAST4 DOCK6 NPR3 RASGRF2 RAPGEF4	1.61e-04	184	195	6	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PALD1 RPS6KA2 CDHR5 RPS6KA4 NUDT17 SLC15A4	1.61e-04	184	195	6	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPA13 PIK3CG KCNN3 MEI1 TRAM1 ANKRD36	1.66e-04	185	195	6	ff598af88c7f9d7224cc4ed96b1c3463ef76b550
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	1.66e-04	185	195	6	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPA13 PIK3CG KCNN3 MEI1 TRAM1 ANKRD36	1.70e-04	186	195	6	b9fb7210f615faff0633a1c82dd3be38cb72a00b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 PLIN5 NPR3 AGXT2 IDO2 SUGCT	1.70e-04	186	195	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPM6 DACH1 NPR3 RAPGEF4 SLC6A4 NR5A2	1.76e-04	187	195	6	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	CETP DACH1 DOCK6 RAPGEF4 SLC6A4 NR5A2	1.76e-04	187	195	6	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCA1 LYST NFIA RASGRF2 GPAM SUGCT	1.76e-04	187	195	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	DACH1 MAST4 DOCK6 NPR3 RASGRF2 RAPGEF4	1.81e-04	188	195	6	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	droplet-Fat-Scat-21m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 MYO10 DACH1 DOCK6 NPR3 RASGRF2	1.81e-04	188	195	6	8671fdbc4138e6f9559920779c98628ed80f0da3
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ATG2A ARAP2 AAK1 MAP4K1 ANKRD36 ATM	1.86e-04	189	195	6	f1129eb122bbc051457c5545f1a267beb988b0f2
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ATG2A ARAP2 AAK1 MAP4K1 ANKRD36 ATM	1.86e-04	189	195	6	0b012ee301419fa9ccc387c3ff66c2344b349a97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 KCNN3 RASGRF2 RAPGEF4 NR5A2 CTNNB1	1.86e-04	189	195	6	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	droplet-Fat-Scat-21m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 MYO10 DACH1 DOCK6 NPR3 RASGRF2	1.91e-04	190	195	6	d3e46cf800a07ca9b01c78192962d223b9785d05
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	MYO10 DACH1 MAST4 NPR3 RAPGEF4 SLC6A4	1.91e-04	190	195	6	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	droplet-Fat-Scat-21m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 MYO10 DACH1 DOCK6 NPR3 RASGRF2	1.91e-04	190	195	6	dd89ef1ecea20b2f6fbdc6cea4ca41b28b3ed822
ToppCell	Control-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	1.97e-04	191	195	6	c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LRRK2 CSGALNACT2 NBEAL2 MAP4K4 MAPK3 UNC80	1.97e-04	191	195	6	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	GAPVD1 LYST HSPA13 GNPTAB TTC17 SELENOI	1.97e-04	191	195	6	9454f642c3621370fa23640b631301346b300950
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 TRPM5 PDE5A AKAP13 GPSM1 UNC80	1.97e-04	191	195	6	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 HSPA13 TRPM5 PREPL PDE5A UNC80	1.97e-04	191	195	6	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	1.97e-04	191	195	6	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PALD1 KCNN3 DOCK6 RASGRF2 RAPGEF4 NR5A2	1.97e-04	191	195	6	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLK2 DOCK6 NPR3 RAPGEF4 DACH2 NR5A2	2.02e-04	192	195	6	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PALD1 RPS6KA2 MAST4 KCNN3 ATP11C DOCK6	2.02e-04	192	195	6	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLK2 MYO10 CETP RPS6KA2 PIK3CG DOCK6	2.02e-04	192	195	6	1f35efb0765e05f7f9c881849953bef3965be25a
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	ACACA RPS6KA2 LRRK2 DUOX1 MAST4 PLIN5	2.02e-04	192	195	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CADM3 AFAP1L2 NPR3 RAPGEF4 DACH2 NR5A2	2.02e-04	192	195	6	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 DOCK6 NPR3 RAPGEF4 DACH2 NR5A2	2.08e-04	193	195	6	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLK2 DACH1 NPR3 RAPGEF4 DACH2 NR5A2	2.08e-04	193	195	6	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS6KA5 ARAP2 AAK1 ANKRD36 ATM ZDHHC11	2.08e-04	193	195	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PLK2 DACH1 NPR3 RAPGEF4 SLC6A4 NR5A2	2.08e-04	193	195	6	ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PALD1 DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4	2.08e-04	193	195	6	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DACH1 DOCK6 NPR3 RAPGEF4 SLC6A4 NR5A2	2.14e-04	194	195	6	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 MAST4 DOCK6 RAPGEF4 DACH2 NR5A2	2.14e-04	194	195	6	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DACH1 MAST4 DOCK6 RAPGEF4 DACH2 NR5A2	2.14e-04	194	195	6	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	Adult-Endothelial\|Adult / Lineage, Cell type, age group and donor	PALD1 DACH1 DOCK6 RAPGEF4 SLC6A4 NR5A2	2.14e-04	194	195	6	963b3fbee0575af8379baa397ace65949eaf34f7
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MFSD6 DACH1 NPR3 RAPGEF4 SLC6A4 NR5A2	2.14e-04	194	195	6	40842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 CETP DOCK6 RASGRF2 RAPGEF4 NR5A2	2.14e-04	194	195	6	e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COG3 ZNF865 PPP4R3A PTPDC1 RPAP1 ANKRD36	2.20e-04	195	195	6	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
Computational	Genes in the cancer module 303.	CHUK BUB1 MAPK14 PKN1 MAPK6	7.29e-06	28	107	5	MODULE_303
Drug	AD 288	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 ATM MAPK3	9.55e-12	14	194	7	CID000073553
Drug	Ovta	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 MAPK3	1.00e-09	14	194	6	CID003081047
Drug	R165481	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 PKN1	2.64e-09	16	194	6	CID005459348
Drug	DEAC	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 MAPK14 MAPK3 MAPK6	2.08e-08	55	194	8	CID000007277
Drug	AC1L1GZB	RPS6KA5 RPS6KA2 RPS6KA3 MAPK12 RPS6KA6 C4A RPS6KA4 MAPK14 CTNNB1 MAPK3 MAPK6 NLK	2.16e-08	167	194	12	CID000003908
Drug	K00085	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 MAPK3	9.03e-08	27	194	6	CID009549283
Drug	A61603	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4 GRK1	3.24e-07	33	194	6	CID004038180
Drug	ruboxistaurin	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 DAPK3 CAMKK1 AAK1 PDE5A MAPK3	3.43e-07	107	194	9	CID000153999
Drug	NSC611747	RPS6KA5 MYO10 PDPK1 RPS6KA2 RPS6KA3 MAPK12 RPS6KA6 KCNN3 RPS6KA4 SLC6A4 MAPK14 AKAP13 PKN1 CTNNB1 MAPK3	3.83e-07	352	194	15	CID000002534
Drug	UV-C	RPS6KA5 LYST TLK1 MAPK12 MAPK14 MAP4K1 ATM MAPK3 MAPK6 NLK	1.42e-06	163	194	10	CID005289542
Drug	BI D1870	RPS6KA2 RPS6KA3 RPS6KA6 MAPK3	1.61e-06	11	194	4	ctd:C516541
Drug	sunitinib	RPS6KA5 RPS6KA2 RPS6KA3 DAPK3 TPCN1 EPM2A CAMKK1 AAK1 CAMK1	1.78e-06	130	194	9	CID005329102
Drug	In-G	RPS6KA5 RPS6KA2 RPS6KA3 CHUK RPS6KA6 PLK3 RPS6KA4 DICER1 MAPK14 MAPK3	2.09e-06	170	194	10	CID000446054
Drug	celiprolol	DUOX1 MAPK12 MAPK14 MAPK3 MAPK6 NLK	2.84e-06	47	194	6	CID000002663
Drug	AC1MS9WM	RPS6KA5 RPS6KA2 RPS6KA3 RPS6KA6 RPS6KA4	2.96e-06	27	194	5	CID003530978
Drug	AC1L1D59	RPS6KA5 RPS6KA2 RPS6KA3 MAPK12 RPS6KA6 RPS6KA4 SLC6A4 MAPK14 MAP4K1 MAPK3 MAPK6 NLK	3.22e-06	266	194	12	CID000002199
Drug	SB202474	MAPK12 MAPK14 MAPK3 MAPK6	4.78e-06	14	194	4	CID000005162
Drug	KT5720	RPS6KA5 MAPK12 NPR3 RAPGEF4 MAPK14 PDE5A AKAP13 PKN1 MAPK3 PTGDR2	5.38e-06	189	194	10	CID000003844
Drug	inhibitor of p38 kinase	RPS6KA5 MAPK12 RPS6KA6 RPS6KA4 MAPK14 MAPK3	5.83e-06	53	194	6	CID000027933
Drug	BiM4	RPS6KA5 RPS6KA2 MAPK12 PIK3CG RPS6KA6 NPR3 RAPGEF4 SLC6A4 MAPK14 PKN1 MAPK3 MAPK6	6.07e-06	283	194	12	CID000002399
Drug	Tinidazole [19387-91-8]; Down 200; 16.2uM; HL60; HT_HG-U133A	UBE4B ZNF813 LYST HSPA13 SLC35A2 BUB1 ERLIN1 PPP4R3A MAPK14 MAP4K1	7.09e-06	195	194	10	2568_DN
Drug	Tosylphenylalanyl Chloromethyl Ketone	ABCA1 CETP PDPK1 GCLC PDE5A CTNNB1	7.26e-06	55	194	6	ctd:D014108
Drug	cadmium selenide	TLR6 CHUK MAPK14 TLR3 MAPK3	9.71e-06	34	194	5	ctd:C058667
Drug	AC1L1CFC	MAPK12 MAPK14 TLR3 MAPK3 MAPK6 NLK	9.92e-06	58	194	6	CID000001874
Drug	alpha-ketoisovalerate	BCKDK MAPK12 CAMK1 MAPK14 MAPK3 MAPK6 NLK	1.12e-05	89	194	7	CID000000049
Drug	Kemptide	RPS6KA5 RPS6KA2 RPS6KA3 CSNK1G1 RPS6KA6 RPS6KA4 AKAP13 PKN1	1.14e-05	124	194	8	CID000100074
Drug	vanadyl	RPS6KA5 MAPK12 SLC35A2 RPS6KA6 DNAH9 RPS6KA4 MAPK14 MAP4K1 PDE5A PKN1 MAPK3 MAPK6	1.38e-05	307	194	12	CID000061671
Drug	SP600125	RPS6KA5 RPS6KA2 DAPK3 MAPK12 CSNK1G1 MAP4K4 AAK1 CAMK1 MAPK14 TLR3 MAPK3 MAPK6 NLK	1.48e-05	362	194	13	CID000008515
Drug	trans-3,4,5-trihydroxystilbene	RPS6KA5 UBE4B LYST MAPK12 GCLC PIK3CG NFIX SLC35A2 BUB1 NPR3 MAPK14 PDE5A CTNNB1 CERS1 MAPK3 MAPK6 NLK	1.92e-05	608	194	17	CID000005056
Drug	wartmannin	RPS6KA5 MYO10 PDPK1 RPS6KA2 RPS6KA3 CHUK TLK1 MAPK12 PIK3CG RPS6KA6 PLK3 DNAJC13 RPS6KA4 MAPK14 PKN1 ATM CTNNB1 MAPK3 MAPK6 NLK	2.14e-05	811	194	20	CID000005691
Drug	procymidone	MAPK12 MAPK14 MAPK3 MAPK6 NLK	2.20e-05	40	194	5	CID000036242
Drug	carbachol	RPS6KA5 RPS6KA2 RPS6KA3 CHUK TPCN1 MAPK12 PIK3CG RPS6KA6 KCNN3 KCNS3 NPR3 RPS6KA4 PIP5K1C MAPK14 MAPK3 MAPK6 PTGDR2 NLK	2.62e-05	688	194	18	CID000002551
Drug	piribedil	MAPK12 MAPK14 MAPK3 MAPK6 NLK	2.81e-05	42	194	5	CID000004850
Drug	Fullerenes	TLR6 CHUK MAPK14 TLR3 MAPK3	2.81e-05	42	194	5	ctd:D037741
Drug	SR144528	MAPK12 MAPK14 PKN1 MAPK3 MAPK6 NLK	2.95e-05	70	194	6	CID003081355
Drug	salinomycin	MYO10 GTF3C3 DNAJC13 FHIP2A INTS8 PREPL MAPK14 CTNNB1 MAPK3	3.11e-05	185	194	9	ctd:C010327
Drug	AC1L1H7K	CHUK MAPK12 PIK3CG FNTB MAPK14 ATM MAPK3 MAPK6	3.37e-05	144	194	8	CID000004010
Drug	3-hydroxyflavone	RPS6KA5 LYST SLC35A2 RPS6KA6 RPS6KA4	3.54e-05	44	194	5	CID000011349
Drug	AC1L1JGQ	RPS6KA5 MAPK12 RPS6KA6 RPS6KA4 MAPK14 MAPK3	3.75e-05	73	194	6	CID000005034
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Down 200; 21uM; MCF7; HT_HG-U133A	DACH1 DAPK3 SLC35A2 BUB1 ZNF480 DICER1 ERLIN1 MAPK14 ELMO2	4.16e-05	192	194	9	2766_DN
Drug	Pipenzolate bromide [125-51-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A	RPS6KA2 TLK1 SEMA3B MPP3 CAMK1 PIP5K1C PPP4R3B RPAP1 TRAPPC14	4.69e-05	195	194	9	6821_DN
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; PC3; HT_HG-U133A	ZNF268 RPS6KA2 NFIX PLK3 AAK1 BAZ1B PIP5K1C ATM TRAPPC14	4.69e-05	195	194	9	6635_DN
Drug	Morantel tartrate [26155-31-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CADM3 PSKH1 RPS6KA2 URB2 MAST4 SEMA3B PLK3 ZNF573 TRAPPC14	4.88e-05	196	194	9	7010_UP
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; MCF7; HT_HG-U133A	TLK1 ZNF480 MPP3 EPM2A RPS6KA4 CAMK1 FEM1B MAPK14 TRAPPC14	5.08e-05	197	194	9	2788_DN
Drug	Ganciclovir [82410-32-0]; Down 200; 15.6uM; PC3; HT_HG-U133A	PSKH1 RPS6KA2 TPCN1 MAPK12 SLC35A2 BAZ1B FEM1B AKAP13 ATM	5.08e-05	197	194	9	6289_DN
Drug	Nitrarine dihydrochloride [20069-05-0]; Down 200; 10.6uM; HL60; HT_HG-U133A	TLK1 SLC35A2 BUB1 DOCK6 ARAP2 MPP3 MAPK14 AKAP13 MAPK3	5.28e-05	198	194	9	2188_DN
Drug	DENSPM	MAPK12 MAPK14 MAPK3 MAPK6 NLK	5.42e-05	48	194	5	CID000004282
Drug	AC1L1IHP	ACACA RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 DAPK3 CHUK MAPK12 CSNK1G1 RPS6KA6 RPS6KA4 PIP5K1C SLC6A4 MAPK14 PKN1 MAPK3 MAPK6 NLK	5.45e-05	728	194	18	CID000004584
Drug	Letrozole [112809-51-5]; Down 200; 14uM; MCF7; HT_HG-U133A	MAPK12 MAST4 NBEAL2 BAZ1B PPP4R3A PPP4R3B RPAP1 AKAP13 NLK	5.71e-05	200	194	9	7336_DN
Drug	AC1NOLIT	MAPK12 MAPK14 MAPK3	6.99e-05	10	194	3	CID005090286
Drug	6-fluorocholesterol	LYST ATM	7.22e-05	2	194	2	CID000135206
Drug	25-fluorocholesterol	LYST ATM	7.22e-05	2	194	2	CID006454807
Drug	zinc sulfide	TLR6 CHUK MAPK14 TLR3 MAPK3	7.29e-05	51	194	5	ctd:C031238
Drug	LY294002	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 CHUK MAPK12 PIK3CG RPS6KA6 RPS6KA4 MAPK14 TLR3 PKN1 ATM CTNNB1 MAPK3 MAPK6 PTGDR2 NLK	7.70e-05	748	194	18	CID000003973
Drug	serotonin	RPS6KA5 PDPK1 RPS6KA2 RPS6KA3 MAPK12 RPS6KA6 MPP3 NPR3 RPS6KA4 SLC6A4 MAPK14 ATM MAPK3 MAPK6 NLK	8.61e-05	554	194	15	CID000005202
Drug	lapatinib	MAPK12 EPM2A MAPK14 MAPK3 MAPK6 NLK	9.46e-05	86	194	6	CID000208908
Drug	cariporide	RPS6KA5 MAPK12 RPS6KA6 RPS6KA4 MAPK14 MAPK3	9.46e-05	86	194	6	CID000151172
Drug	nemorosone	MAPK12 MAPK14 MAPK3	9.56e-05	11	194	3	CID000637105
Drug	oridonin	MAPK12 MAPK14 MAPK3 MAPK6 GPR148	9.61e-05	54	194	5	CID000034378
Drug	2,6-dioxo-6-phenylhex-3-enoic acid	MAPK12 MAP4K4 MAP4K1 PKN1	1.03e-04	29	194	4	CID000000512
Drug	poly(methyl methacrylate) (PMMA	C4A PREPL GRK1 MAPK3 MAPK6	1.15e-04	56	194	5	CID003032549
Drug	trapidil	MAPK12 MAPK14 MAPK3 MAPK6 NLK	1.25e-04	57	194	5	CID000005531
Drug	AC1MBZ1C	RPS6KA5 MAPK12 NPR3 RPS6KA4 RAPGEF4 CAMK1 MAPK14 PDE5A AKAP13 PKN1 MAPK3 MAPK6	1.29e-04	387	194	12	CID000003541
Drug	NSC407322	CETP MAPK12 PPP4R3B MAPK14 MAPK3 MAPK6 NLK	1.34e-04	131	194	7	CID000003977
Drug	CEP-1347	DAPK3 MAPK12 MAPK14 MAPK3 MAPK6	1.47e-04	59	194	5	CID000133005
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	MYO10 ZNF268 RPS6KA2 GTF3C3 HSPA13 CSNK1G1 SEMA3B PPP4R3B	1.49e-04	178	194	8	916_UP
Drug	5'-GMP Na2	DACH1 MAPK12 PIK3CG MAP4K4 NPR3 GTF2H1 MAPK14 PDE5A MAPK3 MAPK6 NLK	1.50e-04	335	194	11	CID000000761
Drug	STO-609	ACACA CAMK1 MAPK3 MAPK6	1.52e-04	32	194	4	CID003467590
Drug	SB202190	RPS6KA5 MAPK12 GRK1 MAPK14 MAPK3 MAPK6 PTGDR2	1.54e-04	134	194	7	CID005353940
Drug	methyl ethyl ketone	RPS6KA5 RPS6KA2 RPS6KA3 CHUK MAPK12 PIK3CG RPS6KA6 RPS6KA4 GPAM GRK1 MAPK14 CTNNB1 MAPK3 MAPK6 NLK	1.62e-04	587	194	15	CID000006569
Drug	5-androstene-3,17-dione	GCLC SLC35A2 STK32C	1.64e-04	13	194	3	CID000160531
Drug	Cymal-6	RPS6KA2 RPS6KA6 EXOSC10	1.64e-04	13	194	3	CID000447688
Drug	everolimus	RPS6KA5 RPS6KA2 RPS6KA3 PIK3CG RPS6KA6 RPS6KA4 ATM	1.69e-04	136	194	7	CID006442177
Drug	Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT_HG-U133A	MAN2A2 DAPK3 LYST SEMA3B FEM1B TRAM1 ATM TRAPPC14	1.74e-04	182	194	8	5292_UP
Drug	GF109203X	RPS6KA5 PDPK1 DAPK3 MAPK12 RPS6KA6 RPS6KA4 CAMK1 MAPK14 PKN1 MAPK3 MAPK6	1.75e-04	341	194	11	CID000002396
Drug	Adamantamine fumarate [80789-67-9]; Down 200; 9.6uM; HL60; HT_HG-U133A	LYST HSPA13 RAD21 DICER1 ERLIN1 MAPK14 ELMO2 TRAM1	1.87e-04	184	194	8	1344_DN
Drug	geranylgeranyl pyrophosphate	ABCA1 MAPK12 FNTB PPP4R3B MAPK14 MAPK3 MAPK6	1.94e-04	139	194	7	CID000000735
Drug	CdCl2	MAPK12 GCLC MAPK14 MAPK3 MAPK6 NLK	1.95e-04	98	194	6	CID000024947
Drug	SB-242235	MAPK12 MAPK14 PKN1	2.07e-04	14	194	3	CID009863367
Drug	malvidin	MAPK14 PDE5A MAPK3	2.07e-04	14	194	3	ctd:C065861
Drug	2-aminothiophenol	C4A C4B	2.15e-04	3	194	2	ctd:C005464
Drug	Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; HL60; HT_HG-U133A	ABCA1 LYST PIK3CG BUB1 PPP4R3A ELMO2 TRAM1 MAPK3	2.17e-04	188	194	8	1299_UP
Drug	Apigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MYO10 RPS6KA3 KCNS3 ZNF573 ARMCX5 PIP5K1C PPP4R3B TTC17	2.17e-04	188	194	8	3257_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A	MYO10 LYST NFIX NPR3 BAZ1B DICER1 AKAP13 ATM	2.41e-04	191	194	8	4283_DN
Drug	AEBSF	DAPK3 DUOX1 MAPK12 PIK3CG MAPK14 MAPK3 MAPK6 NLK	2.41e-04	191	194	8	CID000001701
Drug	1kkq	MAPK12 MAPK14 TRAM1 MAPK3	2.43e-04	36	194	4	CID000446738
Drug	Pindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT_HG-U133A	RPS6KA2 MFSD6 DAPK3 SEMA3B RPS6KA6 EPM2A ERLIN1 MAPK14	2.50e-04	192	194	8	4496_DN
Drug	MMP-2 Inhibitor I	MAPK12 MAPK14 MAPK3	2.57e-04	15	194	3	CID000004220
Drug	phthalazine	LYST MAPK14 PDE5A	2.57e-04	15	194	3	CID000009207
Drug	Carbenoxolone disodium salt [7421-40-1]; Down 200; 6.6uM; MCF7; HT_HG-U133A	MYO10 LYST CSNK1G1 NPR3 EPM2A PPP4R3A MAPK14 AKAP13	2.59e-04	193	194	8	4173_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A	ABCA1 DAPK3 SLC35A2 EPM2A ZNF573 AAK1 ERLIN1 AKAP13	2.59e-04	193	194	8	3773_DN
Drug	1-EBIO	RPS6KA2 RPS6KA3 RPS6KA6 KCNN3	2.71e-04	37	194	4	CID000082320
Drug	Antimycin A [1397-94-0]; Down 200; 7.2uM; PC3; HT_HG-U133A	PLK2 RPS6KA2 MAST4 SLC35A2 EPM2A BAZ1B PPP4R3B VPS41	2.78e-04	195	194	8	5053_DN
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; HL60; HT_HG-U133A	UBE4B ZNF268 ATG2A PIK3CG BUB1 ERLIN1 MAPK14 MAPK3	2.78e-04	195	194	8	1836_DN
Drug	Folic acid [59-30-3]; Up 200; 9uM; MCF7; HT_HG-U133A	RPS6KA5 SLC35A2 SEMA3B ZNF573 AAK1 CAMK1 PPP4R3B MAPK14	2.78e-04	195	194	8	7201_UP
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A	MAN2A2 RPS6KA2 NBEAL2 SEMA3B SERHL2 PKN1 ATM TRAPPC14	2.87e-04	196	194	8	5350_UP
Drug	Carbenoxolone disodium salt [7421-40-1]; Down 200; 6.6uM; MCF7; HT_HG-U133A	RPS6KA2 DACH1 MAST4 PLK3 SERHL2 AAK1 DICER1 TRAPPC14	2.87e-04	196	194	8	3353_DN
Drug	Adamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ABCA1 RPS6KA5 DAPK3 BUB1 ZNF573 GNPTAB CAMK1 TM4SF20	2.87e-04	196	194	8	4806_UP
Drug	Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A	MAN2A2 RPS6KA2 DACH1 DAPK3 URB2 MAST4 ZNF573 TNPO3	2.87e-04	196	194	8	5338_UP
Drug	0316684-0000 [391209-55-5]; Up 200; 10uM; MCF7; HT_HG-U133A	TPCN1 MAST4 SEMA3B MPP3 SERHL2 ZNF573 PIP5K1C TRAPPC14	2.98e-04	197	194	8	7052_UP
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA2 RPS6KA3 RPS6KA6	1.05e-06	4	190	3	DOID:3783 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	RPS6KA2 DAPK3 NEK4 RAD21 PKN1 ATM CTNNB1	3.02e-06	96	190	7	C1319315
Disease	blood pressure, response to thiazide, response to beta blocker	OR5H1 OR5H14	1.23e-04	3	190	2	EFO_0004325, EFO_0007766, EFO_0007981
Disease	erectile dysfunction	ACACA PDPK1 HACD4 NFIA	1.54e-04	42	190	4	EFO_0004234
Disease	autistic disorder (is_implicated_in)	PIK3CG C4B RAPGEF4 SLC6A4	1.54e-04	42	190	4	DOID:12849 (is_implicated_in)
Disease	Gastric Adenocarcinoma	RPS6KA3 MAPK14 ATM CTNNB1	2.02e-04	45	190	4	C0278701
Disease	Infiltrating duct carcinoma of female breast	ANKK1 RPS6KA4 PKN1	3.21e-04	21	190	3	C3165106
Disease	Metastatic melanoma	RPS6KA2 CAMK1 MAP4K1 PKN1	4.10e-04	54	190	4	C0278883
Disease	phospholipids in medium HDL measurement	ABCA1 CETP DOCK6 GPAM	4.40e-04	55	190	4	EFO_0022295
Disease	free cholesterol to total lipids in very large HDL percentage	ABCA1 CETP DOCK6 GPAM	4.40e-04	55	190	4	EFO_0022288
Disease	HDL cholesterol change measurement	ABCA1 CETP DOCK6	4.81e-04	24	190	3	EFO_0007805
Disease	Malignant neoplasm of pancreas	BUB1 SUGCT NR5A2 ATM CTNNB1	5.28e-04	102	190	5	C0346647
Disease	total lipids in medium HDL measurement	ABCA1 CETP DOCK6 GPAM	5.39e-04	58	190	4	EFO_0022310
Disease	free cholesterol in medium HDL measurement	ABCA1 CETP DOCK6 GPAM	5.39e-04	58	190	4	EFO_0022267
Disease	cholesterol in medium HDL measurement	ABCA1 CETP DOCK6 GPAM	5.75e-04	59	190	4	EFO_0021903
Disease	free cholesterol in HDL measurement	ABCA1 CETP DOCK6 GPAM	6.53e-04	61	190	4	EFO_0022264
Disease	phospholipids in HDL measurement	ABCA1 CETP DOCK6 GPAM	6.53e-04	61	190	4	EFO_0022293
Disease	total lipids in HDL measurement	ABCA1 CETP DOCK6 GPAM	7.37e-04	63	190	4	EFO_0022307
Disease	Dysphoric mood	SLC6A4 MAPK14	8.48e-04	7	190	2	C0233477
Disease	Large cell carcinoma of lung	TRPM6 RPS6KA6 ANKK1	1.14e-03	32	190	3	C0345958
Disease	phospholipids in large HDL measurement	ABCA1 CETP DOCK6 GPAM	1.28e-03	73	190	4	EFO_0022190
Disease	total lipids in large HDL	ABCA1 CETP DOCK6 GPAM	1.35e-03	74	190	4	EFO_0022189
Disease	Cocaine Abuse	RPS6KA5 ANKK1 SLC6A4 MAPK3 GPSM1	1.42e-03	127	190	5	C0009171
Disease	Nephronophthisis	IFT172 RPGRIP1L	1.44e-03	9	190	2	cv:C0687120
Disease	free cholesterol in small HDL measurement	ABCA1 CETP DOCK6	1.48e-03	35	190	3	EFO_0022270
Disease	free cholesterol in large HDL measurement	ABCA1 CETP DOCK6 GPAM	1.72e-03	79	190	4	EFO_0022157
Disease	anti-topoisomerase-I-antibody-positive systemic scleroderma	CAMKK1 TNPO3	1.79e-03	10	190	2	EFO_0008537
Disease	cholesterol in large HDL measurement	ABCA1 CETP DOCK6 GPAM	1.80e-03	80	190	4	EFO_0021900
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	PLK2 ABCA1 CETP DOCK6 CALN1 GPAM ERLIN1	2.07e-03	274	190	7	EFO_0004530, EFO_0004612
Disease	Cocaine Dependence	RPS6KA5 ANKK1 SLC6A4 MAPK3 GPSM1	2.11e-03	139	190	5	C0600427
Disease	uric acid measurement	ABCA1 DACH1 KCNS3 QSOX2 DNAJC13 RPS6KA4 AAK1 BAZ1B PTPDC1 NR5A2 AKAP13	2.11e-03	610	190	11	EFO_0004761
Disease	fatty acid measurement	ABCA1 MYO10 CETP NEK4 DOCK6 CALN1 MPP3 BAZ1B GPAM	2.17e-03	436	190	9	EFO_0005110
Disease	Adenocarcinoma of lung (disorder)	TRPM6 PLK2 RPS6KA6 MAPK14 ATM CTNNB1	2.24e-03	206	190	6	C0152013
Disease	lipoprotein measurement, phospholipid measurement	ABCA1 CETP DOCK6 GPAM	2.25e-03	85	190	4	EFO_0004639, EFO_0004732
Disease	stomach cancer (is_marker_for)	DOCK6 MAP4K4 DICER1 ATM CTNNB1	2.31e-03	142	190	5	DOID:10534 (is_marker_for)
Disease	Drug-induced depressive state	SLC6A4 MAPK14	2.61e-03	12	190	2	C0338715
Disease	Oligospermia	TPCN1 DICER1	2.61e-03	12	190	2	C0028960
Disease	alcohol consumption measurement	ACACA RPS6KA5 IFT172 MFSD6 LACTB MAST4 NFIA ARAP2 ANKK1 MPP3 RASGRF2 ERLIN1 SLC6A4 ZNF420 ANKRD36 CERS1 MAPK6	2.89e-03	1242	190	17	EFO_0007878
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	CETP LACTB CALN1 GPAM SLC6A4	2.93e-03	150	190	5	EFO_0004611, EFO_0020947
Disease	eye disease	ABCA1 FRMPD2 STK32C	3.06e-03	45	190	3	EFO_0003966
Disease	liver cirrhosis (implicated_via_orthology)	GCLC PIK3CG	3.07e-03	13	190	2	DOID:5082 (implicated_via_orthology)
Disease	Hyperlipoproteinemia Type IIb	ABCA1 CETP	3.07e-03	13	190	2	C1704417
Disease	colorectal cancer (is_marker_for)	GCLC MAP4K4 DICER1 ATM CTNNB1	3.56e-03	157	190	5	DOID:9256 (is_marker_for)
Disease	benign prostatic hyperplasia	GCLC NUP107	3.57e-03	14	190	2	EFO_0000284
Disease	total lipids in lipoprotein particles measurement	ABCA1 CETP DOCK6	3.67e-03	48	190	3	EFO_0022309
Disease	phosphoglycerides measurement	ABCA1 CETP GPAM	3.67e-03	48	190	3	EFO_0022291
Disease	RS-10-hydroxywarfarin measurement	TRPM6 NXPE2 PIK3CG DOCK6	3.76e-03	98	190	4	EFO_0803330
Disease	triglyceride measurement, alcohol drinking	ABCA1 CETP MPP3 GPAM	3.90e-03	99	190	4	EFO_0004329, EFO_0004530
Disease	Pancreatic Neoplasm	SUGCT NR5A2 ATM CTNNB1	4.04e-03	100	190	4	C0030297
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	ABCA1 CETP LACTB MPP3 GPAM	4.06e-03	162	190	5	EFO_0004612, EFO_0007878
Disease	Medulloblastoma	PIK3CG ATM CTNNB1	4.12e-03	50	190	3	C0025149
Disease	Fibrosis	PIK3CG ATM CTNNB1	4.12e-03	50	190	3	C0016059
Disease	Cirrhosis	PIK3CG ATM CTNNB1	4.12e-03	50	190	3	C1623038
Disease	triglyceride measurement, alcohol consumption measurement	ABCA1 CETP MPP3 GPAM	4.18e-03	101	190	4	EFO_0004530, EFO_0007878
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	ABCA1 CETP CALN1 MPP3 GPAM SLC6A4	4.65e-03	239	190	6	EFO_0008317, EFO_0020945
Disease	Hyperlipoproteinemia Type IIa	ABCA1 CETP	4.66e-03	16	190	2	C0745103
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	ATM CTNNB1	4.66e-03	16	190	2	C0334634
Disease	primary autosomal recessive microcephaly (is_implicated_in)	BUB1 TRAPPC14	4.66e-03	16	190	2	DOID:0070296 (is_implicated_in)
Disease	cystatin C measurement	DACH1 LACTB NFIA KCNS3 BAZ1B RNF123 RPAP1 PDE5A	4.70e-03	402	190	8	EFO_0004617
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	ABCA1 CETP LACTB MPP3 GPAM	4.74e-03	168	190	5	EFO_0004329, EFO_0004612
Disease	lipoprotein measurement	ABCA1 CETP DOCK6 GPAM	4.80e-03	105	190	4	EFO_0004732
Disease	total phospholipids in lipoprotein particles measurement	ABCA1 CETP GPAM	4.86e-03	53	190	3	EFO_0022315
Disease	Schizophrenia	ABCA1 GCLC KCNN3 ZNF480 KCNS3 ANKK1 DICER1 SLC6A4 MAPK14 TLR3 ATM CTNNB1 MAPK3	4.91e-03	883	190	13	C0036341
Disease	Parkinson disease	BCKDK LRRK2 LACTB KCNN3 KCNS3 MAP4K4 CCDC82	4.94e-03	321	190	7	MONDO_0005180
Disease	trauma exposure measurement	ZNF571 NXPE2 KCNS3 RAPGEF4 STK32C	5.23e-03	172	190	5	EFO_0010703
Disease	Multiple congenital anomalies	CHUK CTNNB1	5.26e-03	17	190	2	C0000772
Disease	cyclic adenosine monophosphate measurement	MAST4 ARAP2	5.26e-03	17	190	2	EFO_0010473
Disease	Familial Progressive Myoclonic Epilepsy	EPM2A CERS1	5.26e-03	17	190	2	C0751777
Disease	Atypical Inclusion-Body Disease	EPM2A CERS1	5.26e-03	17	190	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	EPM2A CERS1	5.26e-03	17	190	2	C0751778
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR6 TLR3	5.26e-03	17	190	2	DOID:8677 (biomarker_via_orthology)
Disease	Biotin-Responsive Encephalopathy	EPM2A CERS1	5.26e-03	17	190	2	C0751780
Disease	May-White Syndrome	EPM2A CERS1	5.26e-03	17	190	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	EPM2A CERS1	5.26e-03	17	190	2	C0751781
Disease	creatinine measurement	GAPVD1 USP45 DACH1 DAPK3 LACTB DUOX1 NFIA KCNS3 ASCC3 QSOX2 DNAJC13 INTS8 RNF123 UNC80	5.28e-03	995	190	14	EFO_0004518
Disease	peptide measurement	TLK1 MAPK12 ZNF573 RAPGEF4	5.48e-03	109	190	4	EFO_0010520
Disease	Malignant neoplasm of endometrium	RAD21 CTNNB1	5.90e-03	18	190	2	C0007103
Disease	Action Myoclonus-Renal Failure Syndrome	EPM2A CERS1	5.90e-03	18	190	2	C0751779
Disease	Carcinoma in situ of endometrium	RAD21 CTNNB1	5.90e-03	18	190	2	C0346191
Disease	Hypercholesterolemia, Familial	ABCA1 CETP	5.90e-03	18	190	2	C0020445
Disease	Colorectal Carcinoma	ABCA1 ACACA BUB1 OR1E2 ZNF480 ATP11C RASGRF2 FRMPD2 STK32C RPAP1 CTNNB1	6.03e-03	702	190	11	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGQHTTHILKEVLRY	SUGCT	411	Q9HAC7
VAQLFEVIHLALGHY	URB2	166	Q14146
EVIHLALGHYLLILQ	URB2	171	Q14146
LKILGQLTTDFVHHY	BHLHB9	426	Q6PI77
LGYNRVLEIHKEHLS	AGXT2	61	Q9BYV1
IENRYLHLLHALSLV	LINC00158	6	P58513
LLHLTLEVVEKRYHL	EPC2	261	Q52LR7
YLSFHKLLLHLQGER	CETP	161	P11597
QLGSKLVYVHHLLGE	BUB1	781	O43683
VLIVGHHILYGKIIH	CHTF8	51	P0CG13
AYALLHLLLHEGKAE	C4B	1266	P0C0L5
DLKVENILLHDRGHY	AAK1	176	Q2M2I8
LYRLGKTFSIRHHLA	ADGRG4	101	Q8IZF6
LEKRYQDIIHSIHLA	BAZ1B	1021	Q9UIG0
AYKGHLEIIHLLAES	ANKK1	601	Q8NFD2
LYASIHKIEEGHLAV	ERLIN1	21	O75477
ALALDYLHRHGIIHR	MASTL	141	Q96GX5
DVILHKVFLQGYQLH	ABCA1	176	O95477
LHTRLLHLEDVYVGL	B3GALT1	256	Q9Y5Z6
LALERGYHKLHQLLT	AKAP13	206	Q12802
HLYSFRILHKGEELA	AFAP1L2	411	Q8N4X5
GEKLHRVFHYVLDNL	ACACA	846	Q13085
LLLVEKGRTLYIHGH	ARAP2	1081	Q8WZ64
YHLKRIHRAVLHGNL	ANKRD36	31	A6QL64
IMLIFLGHYLIRHKG	CADM3	346	Q8N126
LALLGLAVLVHKHYG	CDHR5	681	Q9HBB8
ITRLHQYIFSHILRL	DICER1	846	Q9UPY3
TILHVHELYIRAFQK	BCKDK	121	O14874
QRITLEELKHILYHA	CALN1	171	Q9BXU9
DLFLKHLVGGLHTVY	DACH1	216	Q9UI36
DLFLKHLVGGLHTVY	DACH2	96	Q96NX9
LLGHLSIKFEDHYVI	ARMCX5	416	Q6P1M9
AFLHKLLQLAGVRLH	ATG2A	221	Q2TAZ0
HFALLLKYLIHVAIP	ANO8	851	Q9HCE9
FHDAILLYVLALHEV	NPR3	361	P17342
HHIGVSVKELDLYLA	NFIA	166	Q12857
SGHLLLGVVRIYHRK	RAD21	56	O60216
LHYLLRVELAAHKSL	QSOX2	331	Q6ZRP7
QGTVFILYEHLKRHK	IQCH	936	Q86VS3
TILEYLTYLHHKRGE	INTS8	936	Q75QN2
HYHIVQKFLILGDID	NUP107	511	P57740
IEGLHHLYEIIKGIF	PPP4R3A	186	Q6IN85
ILSYIAGILHALIHE	OR5H15	146	A6NDH6
IHDELLKAHYTLGRL	PALD1	71	Q9ULE6
HELFRHGILLITKVF	LRRC9	541	Q6ZRR7
HLYILLYVLLIIHGS	DUOX1	1226	Q9NRD9
VNHLGHFLLTYLLLE	RDH12	146	Q96NR8
ILSYVGGLLHALIHE	OR5H14	146	A6NHG9
VLFYAITTLHNLLLH	CTNNB1	251	P35222
AYISREILRGLAHLH	MAP4K4	131	O95819
LLHALLEKGHIVYVH	EPM2A	251	O95278
FAGLIKLRELHLEHN	LRRTM2	201	O43300
TIQYLAHITGHRLRV	MDN1	686	Q9NU22
HHIGVTIKELDLYLA	NFIX	166	Q14938
YVHLLDIRAARIHKL	RPGRIP1L	551	Q68CZ1
HIHRIEGLSQKFIYL	GNPTAB	391	Q3T906
LPKYHHIVLYLLVIS	NUDT17	176	P0C025
ELLHIYVGIESNHLL	HACD4	71	Q5VWC8
LEYHKHDLLLARTIG	GPSM1	86	Q86YR5
YHLRHLLIAQELADR	GPSM1	311	Q86YR5
RGLKYIHSADIIHRD	MAPK14	136	Q16539
LILFYENRLKDHHLV	MMS19	91	Q96T76
GIRYLHENKIIHRDL	CHUK	131	O15111
LGLEYLHCQKIVHRD	CAMKK1	261	Q8N5S9
LDHLHSLGIIYRDLK	RPS6KA3	181	P51812
HVIHIIDFGLAKEYI	CSNK1G1	181	Q9HCP0
LTLVLNRLYKHGYIH	KIAA1109	56	Q2LD37
RLLISHLSGIRHYEK	LACTB	211	P83111
IHTLAHHLKQERLYV	GAPVD1	6	Q14C86
VRYLHALGITHRDLK	PSKH1	206	P11801
NGHAKVVRLLLEHYR	FEM1B	56	Q9UK73
FLKGHREQRLAHLVL	IDO2	86	Q6ZQW0
LGLIIAYHTREVQLF	KCNN3	331	Q9UGI6
LLRGLKYIHSANVLH	MAPK6	136	Q16659
YLIILHFLRSHNLEG	OR4X1	216	Q8NH49
KIFLHIHGLISADRY	PDE5A	171	O76074
FKLHRKYRDTLILHG	NEK4	736	P51957
GILQFLHIYHAVKDR	GCLC	26	P48506
KQILDGVHYLHSKRI	DAPK3	121	O43293
HIFYALLAGLEHEER	MYO10	261	Q9HD67
QHRIALHVADGLRYL	LRRK2	1971	Q5S007
TLRHSYHEVGLLLLF	KCNS3	316	Q9BQ31
LRGLKYIHSANVLHR	MAPK3	151	P27361
YGGEIVLALEHLHKL	RPS6KA4	141	O75676
VLALEHLHKLGIIYR	RPS6KA4	146	O75676
IYVGEIVLALEHLHK	RPS6KA5	156	O75582
IVLALEHLHKLGIIY	RPS6KA5	161	O75582
LDHLHQLGIVYRDLK	RPS6KA6	186	Q9UK32
LEYLHGKGIIHRDLK	PDPK2P	166	Q6A1A2
LEKYHIIDQFLSHGI	PTPDC1	101	A2A3K4
RHLLHGYEARLLKHV	PTPDC1	271	A2A3K4
GLLVIDHRNYDHILS	GNMT	171	Q14749
GLKYLHSAGILHRDI	NLK	251	Q9UBE8
LHHLYEIIRGILFLN	PPP4R3B	191	Q5MIZ7
AYFFSHKLIELIGHI	MFSD6	496	Q6ZSS7
HKLIELIGHIRVLYI	MFSD6	501	Q6ZSS7
TSIRYIDHAAVLLHG	PTGDR2	26	Q9Y5Y4
ILHKYVALYATHLIR	IFT172	1441	Q9UG01
DLQLVYTHHPLLLRF	MEI1	771	Q5TIA1
ILSYVGGILHALIHE	OR5H1	146	A6NKK0
LHHLYEIIKGILFLN	PPP4R3C	191	Q6ZMV5
LDAVKYLHDLGIVHR	CAMK1	126	Q14012
QTFKGLISLEHLYIH	PXDNL	116	A1KZ92
RAYIHHLLVTNELLA	QTRT2	361	Q9H974
YIHVVDLAKGHIAAL	GALE	241	Q14376
LNLGRHSLDHLLKLY	EXOSC10	396	Q01780
HRILKIYHLFVSLLL	ATM	1436	Q13315
HYTHFERVVKALLIN	CCDC82	336	Q8N4S0
HLYRKYLHGDLIVIR	CSGALNACT2	461	Q8N6G5
LVAEYLALLEDHRHL	DOCK6	1626	Q96HP0
RLALNHKVLHYGDLD	ELMO2	571	Q96JJ3
LYDVFRPLIIHVIHL	COG3	406	Q96JB2
LRIKFFVSHYGLLQH	FRMPD2	426	Q68DX3
AIVLHTYLAVIHPLR	GPR148	141	Q8TDV2
IIYHVIHTILLGSLA	DPY19L4	466	Q7Z388
FRYHNVGILVLFLHD	CERS1	196	P27544
HILTKILYLLNQGEH	COPG2	46	Q9UBF2
IGHFKLIFSLLRVHG	DNAJC13	1771	O75165
QHGAKLVLYLSELIH	LYST	2786	Q99698
KQVIIHAAHYLVLGD	MAN2A2	596	P49641
IRDYVNKELALHIHT	MAN2A2	876	P49641
LEYLHNYGIVHRDLK	MAST4	681	O15021
LVLQREKHFHYLKRG	FNTB	71	P49356
LAHIHYGVRVVKQLS	SELENOI	356	Q9C0D9
YGLHKADVFHVLVID	HSPA13	211	P48723
HILTKILYLINQGEH	COPG1	46	Q9Y678
RKEVLGQFLLYGHIL	DNAH9	1021	Q9NYC9
YLLHHKILETLYTLG	FHIP2A	81	Q5W0V3
IICGLEHLHQRRIVY	GRK1	301	Q15835
LQAHVLLIKAVHGYF	SERHL2	236	Q9H4I8
TLLLFLIISVKYDHH	SLC15A4	546	Q8N697
AYALLHLLLHEGKAE	C4A	1266	P0C0L4
IVLIRLDSHLHTPVY	OR1E2	46	P47887
IDRHYGHLVDAVLVK	MPP3	541	Q13368
HLYSHSILGLLERKE	MAP4K1	561	Q92918
LILDHIYRQVVHGKE	NR5A2	386	O00482
LRHLDLAYNLLEGHR	STK11IP	256	Q8N1F8
IIYEELLHIKALSHL	RAPGEF4	346	Q8WZA2
ILLEVRDHLGHRKQY	NXPE2	131	Q96DL1
FLHEIFHQGLKARIA	RASGRF2	301	O14827
SALEYLHGKGIIHRD	PDPK1	191	O15530
LLHIGIIDILQSYRF	PIP5K1C	391	O60331
GELHELSTRLLLHYS	NBEAL2	836	Q6ZNJ1
FLPVHRSHIDYLLLT	GPAM	226	Q9HCL2
GRKDVLYRALLHGHI	GPAM	286	Q9HCL2
LYRALLHGHIVELLR	GPAM	291	Q9HCL2
EYLLTEKTLHHLALI	SHOC1	966	Q5VXU9
EKTLHHLALIYAALV	SHOC1	971	Q5VXU9
LGLQFLHEHKIVYRD	PKN1	726	Q16512
GLFYIKGIHLEVERL	MROH2B	956	Q7Z745
RGNVKHLVLFLHEAV	SLC35A2	91	P78381
VHHLTLYDLEARGFV	SMCR8	136	Q8TEV9
ALALDYLRGQHIIHR	STK32C	201	Q86UX6
IVRQVLHGLDYLHTK	SRPK3	191	Q9UPE1
ENKHRLIHFSVFLGL	TM4SF20	181	Q53R12
LIHLAIHYYQKALEL	GTF3C3	826	Q9Y5Q9
ELIALKRVGYIRNHH	ASCC3	2126	Q8N3C0
LLLAHGHLYYVRIAH	ATP11C	861	Q8NB49
YSSLLRKHQIIHLGE	ZNF525	226	Q8N782
AYLALRHHTNLLIIL	PIK3CG	1016	P48736
SGLKYLHQRGILHRD	PLK3	171	Q9H4B4
AHYRHRLLGKLAAIQ	TIGD3	306	Q6B0B8
YHEQEEIFKLRLGHL	TLK1	396	Q9UKI8
LKHLYVAVGELLRHF	GTF2H1	461	P32780
LHFIKDRILVYHGAN	TTC13	621	Q8NBP0
NHLGLLLLVLHYFVE	TRAM1L1	216	Q8N609
GLVTHKYVHLVRRTL	ZNF865	806	P0CJ78
YFLKGLSHLHILNLE	TLR3	556	O15455
GYQLILHHRFHVIER	ZNF573	146	Q86YE8
VLILHLKRFHQAGLS	USP45	681	Q70EL2
GAKLHFIRENLHLLE	UNC80	2456	Q8N2C7
AFGLKSQLIIHERIH	ZNF268	396	Q14587
VKLLIEYGVNLHRFL	TRPM6	456	Q9BX84
TLRLIHIFAIHKQLG	TRPM5	846	Q9NZQ8
NVLIVITIIYDHRLH	OR4E1	46	P0C645
FTNLKGLIRHYRTVH	RLF	1321	Q13129
NHLYLGETVRFLLVL	TRAPPC14	36	Q8WVR3
FVKLLHAYNRTHLLA	SEMA3B	116	Q13214
QIHYLRLTIAILRHE	RNF123	401	Q5XPI4
HYLELGRQELFKILH	UBE4B	631	O95155
ELLRLTHVRFYQHLV	TBC1D16	581	Q8TBP0
GLAFIRKAHLITHQI	ZNF585B	416	Q52M93
ADVYHHRGQLKILLD	TOMM70	401	O94826
LIQKRIHGVLYYVEH	PREPL	291	Q4J6C6
QVALRHLIHFLKEIG	VIPAS39	221	Q9H9C1
LADEGLRQHLLHYKL	RPAP1	1341	Q9BWH6
IHYGLHLDATKLLLQ	TTC17	666	Q96AE7
RLYGDLEAILYHVHL	nan	321	Q6ZUG5
RHKILDIGLAYINHL	VPS41	391	P49754
YSSLLRKHQIIHLGE	ZNF813	226	Q6ZN06
IAHLHLSYILLDLRN	TLR6	166	Q9Y2C9
VHHERLLLVSILGFV	SLC30A7	136	Q8NEW0
LGLVHLGQLLIFHIY	ZDHHC11	246	Q9H8X9
HSLLHRNLGLLYIAK	ZMYND12	171	Q9H0C1
ELYHLVILERKESHG	ZNF677	76	Q86XU0
IHGIFKAYIQRLLHA	TNPO3	361	Q9Y5L0
AFYRIALLVRHQKIH	ZNF480	351	Q8WV37
LHKRTAIQHAYRLLI	TPCN1	336	Q9ULQ1
NHLGLVLLVLHYFVE	TRAM1	216	Q15629
LLLHRVENTQGHILY	ZSWIM3	221	Q96MP5
LTLHQRLHTGEKLYE	ZNF420	266	Q8TAQ5
ARIRHLAYEHSVGKL	PLIN5	206	Q00G26
SGLKYLHEQEILHRD	PLK2	191	Q9NYY3
HLLRRKYHISALYVV	UGGT2	1381	Q9NYU1
FYTRHVLQIHRSKGL	SLC6A4	231	P31645
FIRVAYLTQHEKIHG	ZNF571	456	Q7Z3V5
AHYQFLLDLGVRHLV	DUSP23	26	Q9BVJ7
LRYIHAAGIIHRDLK	MAPK12	141	P53778
ALDHLHSLGIIYRDL	RPS6KA2	171	Q15349