Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

9.85e-1011415011GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.43e-0912415011GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

6.99e-0913715011GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 CTSD USP17L8 USP17L13

2.40e-0819215012GO:0008234
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN9A

2.89e-06141504GO:0031402
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH10 DNAH2 DNAH1 FRRS1L DNAH6

8.03e-06371505GO:0045505
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH10 DNAH2 DNAH1 DNAH6

8.62e-06181504GO:0008569
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN9A

4.02e-05261504GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN9A

4.02e-05261504GO:0031420
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH10 DNAH2 DNAH1 DNAH6

5.44e-05281504GO:0051959
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH10 MYO9A MYO9B DNAH2 DNAH1 DNAH6

2.68e-041181506GO:0003774
GeneOntologyMolecularFunctionpeptidase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 ACE USP17L17 AFG3L2 USP17L6P USP17L3 USP17L22 CTSD USP17L8 USP17L13

4.24e-0465415014GO:0008233
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN9A

6.26e-04521504GO:0005272
GeneOntologyMolecularFunctionATP-dependent activity

DNAH10 RTEL1 MYO9A MYO9B CECR2 ANXA5 RHOBTB3 DNAH2 ABCC5 DNAH1 ABCG4 AFG3L2 DNAH6

7.55e-0461415013GO:0140657
GeneOntologyMolecularFunctionprotein kinase A binding

EZR RDX GSK3B PRKACG

9.47e-04581504GO:0051018
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.77e-0912514911GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

7.92e-0914414911GO:0070646
GeneOntologyBiologicalProcesspositive regulation of early endosome to late endosome transport

EZR RDX MSN

3.01e-0591493GO:2000643
GeneOntologyBiologicalProcessregulation of protein localization to early endosome

EZR RDX MSN

4.27e-05101493GO:1902965
GeneOntologyBiologicalProcesspositive regulation of protein localization to early endosome

EZR RDX MSN

4.27e-05101493GO:1902966
GeneOntologyBiologicalProcessestablishment of cell polarity

DOCK2 EZR MYO9A MYO9B GSK3B MSN PLEKHG3 CDH5

4.47e-051771498GO:0030010
GeneOntologyBiologicalProcesspolarized epithelial cell differentiation

EZR AHI1 MYO9A MSN

6.19e-05301494GO:0030859
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

EZR DPYSL3 AHI1 USP17L2 PDGFRB SYNE1 DNAH2 RDX ARHGAP35 ITGB4 GSK3B DNAH1 ANLN TTLL1 SPAG17

1.06e-0467014915GO:0120031
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

DOCK2 EZR MYO9A MYO9B ARHGAP35 GSK3B MSN PLEKHG3 CDH5

1.08e-042571499GO:0007163
GeneOntologyBiologicalProcesspositive regulation of protein localization to endosome

EZR RDX MSN

1.27e-04141493GO:1905668
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN9A

1.29e-04361494GO:0086010
GeneOntologyBiologicalProcesscell projection assembly

EZR DPYSL3 AHI1 USP17L2 PDGFRB SYNE1 DNAH2 RDX ARHGAP35 ITGB4 GSK3B DNAH1 ANLN TTLL1 SPAG17

1.35e-0468514915GO:0030031
GeneOntologyBiologicalProcessregulation of protein localization to endosome

EZR RDX MSN

1.58e-04151493GO:1905666
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

DOCK2 PDGFRB MYO9A MYO9B ARHGAP26 RDX ARHGAP35 BNIP2 PLEKHG3 DEF6

1.58e-0433314910GO:0051056
GeneOntologyBiologicalProcessprotein localization to early endosome

EZR RDX MSN

1.93e-04161493GO:1902946
GeneOntologyCellularComponentinner dynein arm

DNAH10 DNAH2 DNAH1 DNAH6

4.90e-07101484GO:0036156
GeneOntologyCellularComponentT-tubule

EZR RDX DYSF STAC MSN SCN1A SCN2A

1.46e-06791487GO:0030315
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN9A

5.34e-06171484GO:0001518
GeneOntologyCellularComponentcilium

EZR ANO2 AHI1 DNAH10 STARD10 DNAH2 AMBRA1 PRAMEF17 ARHGAP35 PTCH1 ACE DNAH1 EFHC1 SAG PRKACG TTLL1 SPAG17 CATSPERG USH2A DNAH6

5.57e-0689814820GO:0005929
GeneOntologyCellularComponentsarcolemma

EZR ANXA5 RDX DYSF STAC SLC2A5 MSN SCN1A SCN2A

8.66e-061901489GO:0042383
GeneOntologyCellularComponentaxonemal dynein complex

DNAH10 DNAH2 DNAH1 DNAH6

2.72e-05251484GO:0005858
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN9A

4.99e-05291484GO:0034706
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

USP17L7 RPL27 USP17L4 FMO1 USP17L2 MBOAT1 USP17L1 SYNE1 USP17L10 PIGA USP17L17 FRRS1L USP17L6P USP17L3 ELOVL3 SEL1L2 USP17L22 KDSR RNF145 LMBRD1 USP17L8 USP17L13 OR2W6P

5.93e-05132714823GO:0042175
GeneOntologyCellularComponentendoplasmic reticulum membrane

USP17L7 RPL27 USP17L4 FMO1 USP17L2 MBOAT1 USP17L1 USP17L10 PIGA USP17L17 FRRS1L USP17L6P USP17L3 ELOVL3 SEL1L2 USP17L22 KDSR RNF145 LMBRD1 USP17L8 USP17L13 OR2W6P

1.14e-04129314822GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

USP17L7 RPL27 USP17L4 FMO1 USP17L2 MBOAT1 USP17L1 USP17L10 PIGA USP17L17 FRRS1L USP17L6P USP17L3 ELOVL3 SEL1L2 USP17L22 KDSR RNF145 LMBRD1 USP17L8 USP17L13 OR2W6P

1.22e-04129914822GO:0098827
GeneOntologyCellularComponentanchoring junction

EZR RPL27 AHI1 PDGFRB ANXA5 ARHGAP26 STARD10 AMBRA1 RDX TNS2 PTPRU LCP2 ITGB4 MSN SCN1A SCN2A DEF6 CDH5

1.91e-0497614818GO:0070161
GeneOntologyCellularComponentcell tip

EZR RDX MSN

2.20e-04171483GO:0051286
GeneOntologyCellularComponentmotile cilium

DNAH10 STARD10 DNAH2 PRAMEF17 ACE DNAH1 TTLL1 SPAG17 CATSPERG DNAH6

2.25e-0435514810GO:0031514
GeneOntologyCellularComponentcell pole

EZR RDX MSN

3.63e-04201483GO:0060187
GeneOntologyCellularComponentdynein complex

DNAH10 DNAH2 DNAH1 DNAH6

5.80e-04541484GO:0030286
GeneOntologyCellularComponentaxoneme

DNAH10 DNAH2 AMBRA1 DNAH1 EFHC1 SPAG17 DNAH6

6.95e-042071487GO:0005930
GeneOntologyCellularComponentciliary plasm

DNAH10 DNAH2 AMBRA1 DNAH1 EFHC1 SPAG17 DNAH6

7.15e-042081487GO:0097014
GeneOntologyCellularComponentactin-based cell projection

EZR MYO9B STARD10 RDX PKHD1L1 MSN DEF6 USH2A

8.38e-042781488GO:0098858
GeneOntologyCellularComponentfocal adhesion

EZR RPL27 PDGFRB ANXA5 ARHGAP26 AMBRA1 RDX TNS2 ITGB4 MSN

1.02e-0343114810GO:0005925
GeneOntologyCellularComponentcell-cell junction

EZR AHI1 ANXA5 STARD10 RDX PTPRU LCP2 MSN SCN1A SCN2A DEF6 CDH5

1.04e-0359114812GO:0005911
GeneOntologyCellularComponentcell-substrate junction

EZR RPL27 PDGFRB ANXA5 ARHGAP26 AMBRA1 RDX TNS2 ITGB4 MSN

1.25e-0344314810GO:0030055
GeneOntologyCellularComponentcation channel complex

KCNV2 SLC5A3 SCN1A SCN2A SCN3A SCN9A CATSPERG

1.45e-032351487GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

ANO2 KCNV2 SLC5A3 SCN1A SCN2A SCN3A LRRTM4 SCN9A CATSPERG

1.52e-033781489GO:0034702
GeneOntologyCellularComponenteukaryotic translation initiation factor 3 complex, eIF3m

EIF3CL EIF3C

1.73e-0391482GO:0071541
GeneOntologyCellularComponentfilopodium

EZR MYO9B RDX MSN DEF6

1.84e-031231485GO:0030175
HumanPhenoFocal hemiclonic seizure

PIGA SCN1A FRRS1L SCN2A SCN9A

9.22e-0625615HP:0006813
HumanPhenoPhotosensitive tonic-clonic seizure

EFHC1 SCN1A SCN2A SCN9A

2.30e-0515614HP:0007207
HumanPhenoCogwheel rigidity

CP SCN1A FRRS1L SCN2A SCN9A

3.28e-0532615HP:0002396
HumanPhenoVisually-induced seizure

EFHC1 SCN1A SCN2A SCN9A

5.02e-0518614HP:0020216
HumanPhenoLimitation of knee mobility

HGD DYSF SCN1A SCN2A SCN9A

5.14e-0535615HP:0010501
HumanPhenoEEG with generalized polyspikes

EFHC1 PIGA FRRS1L

5.53e-057613HP:0012001
HumanPhenoAbnormal knee physiology

HGD PDGFRB SYNE1 DYSF SCN1A SCN2A SCN9A

6.87e-0587617HP:0034670
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

8.77e-058613HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

8.77e-058613HP:0200048
HumanPhenoTalipes valgus

SCN1A SCN2A SCN9A DNMT3A

9.57e-0521614HP:0004684
HumanPhenoReflex seizure

EFHC1 SCN1A SCN2A SCN9A

1.16e-0422614HP:0020207
HumanPhenoFocal clonic seizure

PIGA SCN1A FRRS1L SCN2A SCN9A

1.26e-0442615HP:0002266
HumanPhenoRigidity

PDGFRB CP PIGA SCN1A FRRS1L SCN2A SCN3A AFG3L2 SCN9A CTSD

1.91e-042146110HP:0002063
DomainUCH

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.92e-107114610PF00443
DomainUSP_2

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.92e-107114610PS00973
DomainUSP_3

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

2.21e-107214610PS50235
DomainUSP_dom

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

2.21e-107214610IPR028889
DomainPeptidase_C19_UCH

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

2.21e-107214610IPR001394
DomainHABP4_PAI-RBP1

USP17L7 USP17L2 USP17L17 USP17L3 USP17L22 USP17L13

1.55e-09161466PF04774
DomainHABP4_PAIRBP1-bd

USP17L7 USP17L2 USP17L17 USP17L3 USP17L22 USP17L13

1.55e-09161466IPR006861
DomainUSP_CS

USP17L7 USP17L2 USP17L1 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

2.15e-09661469IPR018200
DomainUSP_1

USP17L7 USP17L4 USP17L2 USP17L10 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

3.69e-09701469PS00972
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

5.31e-0861464PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

5.31e-0861464IPR024583
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN9A

7.26e-07101464IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN9A

7.26e-07101464IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN9A

7.26e-07101464PF06512
DomainERM_C_dom

EZR RDX MSN

1.86e-0641463IPR011259
DomainERM

EZR RDX MSN

1.86e-0641463PF00769
DomainERM

EZR RDX MSN

1.86e-0641463IPR011174
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464IPR013602
DomainDHC_N2

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464PF08393
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464IPR011704
DomainMT

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464PF12777
DomainAAA_8

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464PF12780
DomainAAA_5

DNAH10 DNAH2 DNAH1 DNAH6

3.38e-06141464PF07728
DomainDHC_fam

DNAH10 DNAH2 DNAH1 DNAH6

4.57e-06151464IPR026983
DomainDynein_heavy

DNAH10 DNAH2 DNAH1 DNAH6

4.57e-06151464PF03028
DomainDynein_heavy_dom

DNAH10 DNAH2 DNAH1 DNAH6

4.57e-06151464IPR004273
DomainMoesin_tail

EZR RDX MSN

1.60e-0571463IPR008954
DomainIQ

MYO9A MYO9B SCN1A SCN2A SCN3A SCN9A

4.12e-05811466SM00015
DomainTransmembrane_161A/B

TMEM161B TMEM161A

6.07e-0521462IPR019395
DomainTmemb_161AB

TMEM161B TMEM161A

6.07e-0521462PF10268
DomainDUF3512

BRD7 BRD9

6.07e-0521462IPR021900
DomainEIF3C_N_dom

EIF3CL EIF3C

6.07e-0521462IPR008905
DomaineIF-3c_N

EIF3CL EIF3C

6.07e-0521462PF05470
DomainDUF3512

BRD7 BRD9

6.07e-0521462PF12024
DomainEIF3C

EIF3CL EIF3C

6.07e-0521462IPR027516
DomainIQ_motif_EF-hand-BS

MYO9A MYO9B SCN1A SCN2A SCN3A SCN9A

7.47e-05901466IPR000048
DomainChannel_four-helix_dom

KCNV2 SCN1A SCN2A SCN3A SCN9A

8.23e-05571465IPR027359
Domain-

KCNV2 SCN1A SCN2A SCN3A SCN9A

8.23e-055714651.20.120.350
DomainIQ

MYO9A MYO9B SCN1A SCN2A SCN3A SCN9A

8.97e-05931466PS50096
DomainBROMODOMAIN_1

CECR2 PBRM1 BRD7 BRD9

1.94e-04371464PS00633
DomainBromodomain

CECR2 PBRM1 BRD7 BRD9

2.15e-04381464PF00439
DomainIQ

MYO9A MYO9B SCN1A SCN3A SCN9A

2.34e-04711465PF00612
DomainBROMODOMAIN_2

CECR2 PBRM1 BRD7 BRD9

2.90e-04411464PS50014
DomainBromodomain

CECR2 PBRM1 BRD7 BRD9

3.18e-04421464IPR001487
DomainBROMO

CECR2 PBRM1 BRD7 BRD9

3.18e-04421464SM00297
Domain-

CECR2 PBRM1 BRD7 BRD9

3.18e-044214641.20.920.10
DomainEz/rad/moesin-like

EZR RDX MSN

5.61e-04211463IPR000798
DomainFERM_CS

EZR RDX MSN

8.40e-04241463IPR019747
DomainAAA

DNAH10 DNAH2 ABCC5 ABCG4 AFG3L2 DNAH6

9.48e-041441466SM00382
DomainAAA+_ATPase

DNAH10 DNAH2 ABCC5 ABCG4 AFG3L2 DNAH6

9.48e-041441466IPR003593
DomainFERM_C

EZR RDX MSN

1.07e-03261463PF09380
DomainFERM_PH-like_C

EZR RDX MSN

1.19e-03271463IPR018980
DomainFERM_C

EZR RDX MSN

1.19e-03271463SM01196
DomainRhoGAP

MYO9A MYO9B ARHGAP26 ARHGAP35

1.41e-03621464SM00324
DomainRhoGAP

MYO9A MYO9B ARHGAP26 ARHGAP35

1.49e-03631464PF00620
DomainRhoGAP_dom

MYO9A MYO9B ARHGAP26 ARHGAP35

1.58e-03641464IPR000198
DomainZF_DAG_PE_1

MYO9A MYO9B TNS2 STAC

1.58e-03641464PS00479
DomainZF_DAG_PE_2

MYO9A MYO9B TNS2 STAC

1.58e-03641464PS50081
DomainRHOGAP

MYO9A MYO9B ARHGAP26 ARHGAP35

1.58e-03641464PS50238
Domain-

MYO9A MYO9B ARHGAP26 ARHGAP35

1.58e-036414641.10.555.10
DomainDHC_N1

DNAH10 DNAH2

1.65e-0381462PF08385
DomainDynein_heavy_dom-1

DNAH10 DNAH2

1.65e-0381462IPR013594
DomainC1

MYO9A MYO9B TNS2 STAC

1.68e-03651464SM00109
DomainPE/DAG-bd

MYO9A MYO9B TNS2 STAC

1.77e-03661464IPR002219
DomainIon_trans_dom

KCNV2 SCN1A SCN2A SCN3A SCN9A

2.02e-031141465IPR005821
DomainIon_trans

KCNV2 SCN1A SCN2A SCN3A SCN9A

2.02e-031141465PF00520
DomainFERM_N

EZR RDX MSN

2.15e-03331463IPR018979
DomainFERM_N

EZR RDX MSN

2.15e-03331463PF09379
Domain-

LRP1B TENM3 ROS1

3.48e-033914632.120.10.30
DomainRho_GTPase_activation_prot

MYO9A MYO9B ARHGAP26 ARHGAP35

5.03e-03881464IPR008936
DomainAcyl_CoA_acyltransferase

ATE1 GLYATL1 NAA20

5.22e-03451463IPR016181
DomainFERM_M

EZR RDX MSN

5.56e-03461463PF00373
Domain6-blade_b-propeller_TolB-like

LRP1B TENM3 ROS1

5.56e-03461463IPR011042
DomainLY

LRP1B ROS1

5.96e-03151462SM00135
DomainLDLR_classB_rpt

LRP1B ROS1

5.96e-03151462IPR000033
DomainPH_dom-like

EZR NBEAL1 ARHGAP26 RDX TNS2 MSN ANLN PLEKHG3 DEF6

6.38e-034261469IPR011993
Domain-

EZR RDX MSN

6.63e-034914631.20.80.10
DomainFERM_central

EZR RDX MSN

6.63e-03491463IPR019748
DomainFERM_domain

EZR RDX MSN

6.63e-03491463IPR000299
DomainP-loop_NTPase

DRG2 DNAH10 RTEL1 MYO9A MYO9B RHOBTB3 DNAH2 ABCC5 PFKFB2 ARHGAP35 DNAH1 ABCG4 AFG3L2 DNAH6

6.69e-0384814614IPR027417
DomainPINT

EIF3CL EIF3C

6.78e-03161462SM00088
DomainFERM/acyl-CoA-bd_prot_3-hlx

EZR RDX MSN

7.01e-03501463IPR014352
DomainFERM_1

EZR RDX MSN

7.01e-03501463PS00660
DomainFERM_2

EZR RDX MSN

7.01e-03501463PS00661
DomainFERM_3

EZR RDX MSN

7.01e-03501463PS50057
DomainBand_41_domain

EZR RDX MSN

7.01e-03501463IPR019749
DomainB41

EZR RDX MSN

7.01e-03501463SM00295
DomainPCI_dom

EIF3CL EIF3C

7.64e-03171462IPR000717
DomainPCI

EIF3CL EIF3C

7.64e-03171462PF01399
PathwayREACTOME_RAS_PROCESSING

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.02e-134512211MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L7 USP17L4 USP17L2 USP17L1 PSMD8 USP17L10 USP17L17 USP17L6P USP17L3 TNKS USP17L22 USP17L8 USP17L13

1.04e-0819112213MM15289
PathwayREACTOME_DEUBIQUITINATION

USP17L7 USP17L4 USP17L2 USP17L1 PSMD8 USP17L10 USP17L17 USP17L6P USP17L3 TNKS USP17L22 USP17L8 USP17L13

4.25e-0726212213MM15286
PathwayWP_PTDINS45P2_IN_CYTOKINESIS_PATHWAY

EZR RDX MSN ANLN

2.51e-06121224M45558
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L4 USP17L2 USP17L1 PSMD8 USP17L10 USP17L17 USP17L3 TNKS USP17L22 USP17L8 USP17L13

3.35e-0622112211M27578
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L7 USP17L4 USP17L2 USP17L1 PDGFRB PSMD8 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

3.71e-0631812213MM15278
PathwayREACTOME_RHOA_GTPASE_CYCLE

DOCK2 MYO9A MYO9B ARHGAP26 ARHGAP35 ANLN PLEKHG3 DEF6

3.19e-051421228MM15576
PathwayREACTOME_RHOA_GTPASE_CYCLE

DOCK2 MYO9A MYO9B ARHGAP26 ARHGAP35 ANLN PLEKHG3 DEF6

4.50e-051491228M41805
PathwayREACTOME_DEUBIQUITINATION

USP17L4 USP17L2 USP17L1 PSMD8 USP17L10 USP17L17 USP17L3 TNKS USP17L22 USP17L8 USP17L13

5.65e-0529912211M27574
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH10 DNAH2 DNAH1 DNAH6

8.03e-05271224M47755
PathwayREACTOME_L1CAM_INTERACTIONS

EZR RDX MSN SCN1A SCN2A SCN3A SCN9A

8.55e-051211227M872
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN9A

1.40e-04311224M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN9A

1.59e-04321224M27455
PathwayREACTOME_RHOB_GTPASE_CYCLE

MYO9A MYO9B ARHGAP26 ARHGAP35 ANLN

3.23e-04691225MM15596
PathwayBIOCARTA_SHH_PATHWAY

PTCH1 GSK3B PRKACG

3.26e-04161223M11792
PathwayREACTOME_RHOB_GTPASE_CYCLE

MYO9A MYO9B ARHGAP26 ARHGAP35 ANLN

3.45e-04701225M41806
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

MBOAT1 GSK3B TNKS

3.94e-04171223M39525
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EZR RPL27 DPYSL3 MYO9B RDX PSMD8 ARHGAP35 GSK3B MSN SCN1A SCN2A SCN3A SCN9A PRKACG

4.46e-0457512214M29853
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH10 DNAH2 DNAH1 DNAH6

5.08e-04431224M47669
PathwayBIOCARTA_LIS1_PATHWAY

DNAH2 DNAH1 DNAH6

5.54e-04191223M22005
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH10 DNAH2 DNAH1 DNAH6

6.05e-04451224M47670
PathwayWP_CONVERSION_OF_ANGIOTENSINOGEN_TO_ANGIOTENSIN_II

ACE CTSD

7.30e-0451222M45547
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-2121151118622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-21211511114583620
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-21211511111468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-2121151118756639
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-21211511112447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.42e-21211511118980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

4.83e-2122151119154835
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.70e-2024151118995226
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

3.02e-20251511121115691
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

5.21e-20261511135816173
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.31e-19291511132527007
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.27e-18331511120228807
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511120403174
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511114699124
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511115780755
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511119188362
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511111941478
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511117109758
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511120388806
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511120715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-1834151119806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511120368735
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511110936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

1.87e-18341511121448158
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.72e-18351511116611142
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.72e-18351511121239494
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 PRAMEF17 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

3.03e-18501511231806660
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

3.90e-18361511120147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

5.54e-18371511120228808
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8

3.00e-1510151724207026
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8

1.97e-1412151724695638
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8

8.45e-1414151711793228
Pubmed

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8

1.22e-1219151728067227
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

1.70e-09515148812438
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN9A

5.09e-096151423652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN9A

4.23e-089151416382098
Pubmed

Finding the Unicorn, a New Mouse Model of Midfacial Clefting.

EZR RDX PTCH1 MSN

4.23e-089151431940751
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 NDN PRAMEF17 USP17L17 SCN2A SCN3A USP17L6P USP17L3 USP17L22 CATSPERG USP17L8 USP17L13

4.52e-086741511637196079
Pubmed

A neurogenomics approach to gene expression analysis in the developing brain.

PSMD8 TRIP12 EIF3CL SLITRK2 CST5 CD68 ZFHX3 EIF3C CTSD

6.27e-08170151915582152
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8

6.72e-0881151712838346
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

8.02e-083151319284629
Pubmed

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

EZR RDX MSN

8.02e-08315138479753
Pubmed

Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.

EZR RDX MSN

8.02e-083151318261459
Pubmed

Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.

EZR RDX MSN

8.02e-083151321659656
Pubmed

Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.

EZR RDX MSN

8.02e-083151319064715
Pubmed

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

EZR RDX MSN

8.02e-083151321864676
Pubmed

Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.

EZR RDX MSN

8.02e-083151314613898
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

8.02e-083151333895391
Pubmed

Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.

EZR RDX MSN

8.02e-083151326555866
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

8.02e-083151323859570
Pubmed

Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.

EZR RDX MSN

8.02e-083151323703860
Pubmed

Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.

EZR RDX MSN

8.02e-083151316889625
Pubmed

Effect of knockdown of ezrin, radixin, and moesin on P-glycoprotein function in HepG2 cells.

EZR RDX MSN

8.02e-083151321837648
Pubmed

Ezrin and moesin function together to promote T cell activation.

EZR RDX MSN

8.02e-083151319124745
Pubmed

Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

EZR RDX MSN

8.02e-083151322132106
Pubmed

Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.

EZR RDX MSN

8.02e-083151319321616
Pubmed

Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.

EZR RDX MSN

8.02e-083151329906485
Pubmed

Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.

EZR RDX MSN

8.02e-083151331843195
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

8.02e-083151312610651
Pubmed

Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.

EZR RDX MSN

8.02e-083151321278069
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

8.02e-083151318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

8.02e-083151317544618
Pubmed

Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import.

EZR RDX MSN

8.02e-083151315149851
Pubmed

ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.

EZR RDX MSN

8.02e-083151321352885
Pubmed

A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.

EZR RDX MSN

8.02e-08315131429901
Pubmed

ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.

EZR RDX MSN

8.02e-083151332098334
Pubmed

Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection.

EZR RDX MSN

8.02e-083151318295815
Pubmed

Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.

EZR RDX MSN

8.02e-083151312360288
Pubmed

Dynamics and function of ERM proteins during cytokinesis in human cells.

EZR RDX MSN

8.02e-083151328889652
Pubmed

Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.

EZR RDX MSN

8.02e-083151323116763
Pubmed

Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.

EZR RDX MSN

8.02e-083151321451358
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

8.02e-083151314973256
Pubmed

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

EZR RDX MSN

8.02e-083151320679347
Pubmed

Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells.

EZR RDX MSN

8.02e-083151312385025
Pubmed

Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?

EZR RDX MSN

8.02e-083151325286001
Pubmed

Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.

EZR RDX MSN

8.02e-083151317977945
Pubmed

Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS.

EZR RDX MSN

8.02e-083151315252013
Pubmed

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.

EZR RDX MSN

8.02e-083151332160548
Pubmed

The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.

EZR RDX MSN

8.02e-083151312734202
Pubmed

Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath.

EZR RDX ITGB4 MSN

1.64e-0712151418579745
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN9A

2.37e-0713151415123669
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

3.20e-074151317537961
Pubmed

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.

EZR RDX MSN

3.20e-074151327793041
Pubmed

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

EZR RDX MSN

3.20e-074151315096511
Pubmed

Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.

EZR RDX MSN

3.20e-074151317237445
Pubmed

Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering.

EZR RDX MSN

3.20e-074151315178693
Pubmed

Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.

EZR RDX MSN

3.20e-074151320660156
Pubmed

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.

EZR RDX MSN

3.20e-074151319129194
Pubmed

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.

EZR RDX MSN

3.20e-074151331018575
Pubmed

Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion.

EZR RDX MSN

3.20e-074151324760896
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

3.20e-074151335801810
Pubmed

Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.

EZR RDX MSN

3.20e-074151320855527
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

3.20e-074151335031483
Pubmed

Functional binding interaction identified between the axonal CAM L1 and members of the ERM family.

EZR RDX MSN

3.20e-074151312070130
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

3.20e-074151329578003
Pubmed

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

EZR RDX MSN

3.20e-074151319890007
Pubmed

The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.

EZR RDX MSN

3.20e-074151328302370
Pubmed

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.

EZR RDX MSN

3.20e-074151322685202
Pubmed

CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.

EZR RDX MSN

3.20e-074151321289089
Pubmed

The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes.

EZR RDX MSN

3.20e-074151321148287
Cytoband8p23.1

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 TNKS USP17L8

8.58e-0715415178p23.1
Cytoband4p16.1

USP17L10 USP17L17 USP17L6P USP17L22 USP17L13

6.67e-067915154p16.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 TNKS USP17L8

1.35e-052341517chr8p23
Cytoband2q24

SCN3A SCN9A

5.80e-041115122q24
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN9A

8.49e-041271514chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L10 USP17L17 USP17L6P USP17L22 USP17L13

8.73e-042221515chr4p16
Cytoband2q24.3

SCN1A SCN2A

1.25e-031615122q24.3
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN9A

8.83e-0899541203
GeneFamilyDyneins, axonemal

DNAH10 DNAH2 DNAH1 DNAH6

1.62e-0617954536
GeneFamilyMyosins, class IX

MYO9A MYO9B

2.73e-0529521103
CoexpressionMADAN_DPPA4_TARGETS

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

2.71e-128615111MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

5.12e-1111215111MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 CD68 USP17L22 USP17L8 USP17L13

1.59e-1016015112MM1155
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

USP17L7 USP17L4 USP17L2 USP17L1 STARD10 USP17L10 ITGB4 USP17L17 CTR9 USP17L6P USP17L3 CD68 TTLL1 USP17L22 USP17L8 USP17L13

1.11e-0664715116MM981
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L7 USP17L4 USP17L2 USP17L1 KDM5C USP17L10 LCP2 BNIP2 PBRM1 CNOT6L USP17L17 USP17L6P USP17L3 TOMM34 ACOT2 USP17L22 CTSD USP17L8 USP17L13

1.37e-05107215119MM1031
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 LRP1B PKHD1L1 DNAH1 SLITRK2 SCN2A SCN9A ROS1 SPAG17 USH2A

3.60e-11184150112cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 LRP1B PKHD1L1 DNAH1 SLITRK2 SCN2A SCN9A ROS1 SPAG17 USH2A

3.60e-11184150112b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 LRP1B PKHD1L1 DNAH1 SLITRK2 SCN2A SCN9A ROS1 SPAG17 USH2A

3.60e-1118415011ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 LRP1B PKHD1L1 DNAH1 SCN3A SCN9A PLD5 USH2A DNAH6

6.33e-09169150912bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

SGIP1 CECR2 RHOBTB3 ABCC5 LRP1B STAC SCN2A SCN3A PCCA

1.60e-081881509df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 KCNV2 CECR2 LRP1B PKHD1L1 LRRTM4 PLD5 USH2A

7.35e-081601508c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 KCNV2 CECR2 LRP1B PKHD1L1 LRRTM4 PLD5 USH2A

7.35e-08160150825c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 PTCH1 ACKR4 PKHD1L1 SCN3A TTLL1 PLD5 DNAH6

2.07e-071831508919c9861073d12fd12aecd7469b1478b13838c43
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

DNAH10 MYO9B SYNE1 ARHGAP26 GNPTAB ENPP4 PTCH1 MSN

2.15e-071841508791f1bcb954aadc63d4117c400537d036f68734d
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOC2A DNAH10 SYNE1 PFKFB2 SCN1A ROS1 SPAG17 DNAH6

3.10e-071931508bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

PDGFRB SYNE1 GNPTAB PTCH1 EIF3CL MSN PLEKHG3 EIF3C

4.06e-0720015082281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 LRP1B PKHD1L1 FRRS1L SCN9A ROS1 USH2A

1.32e-061621507bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SGIP1 MYO9A RHOBTB3 SLC5A3 VPS13D DNAH6 DNMT3A

1.37e-061631507cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 CP ACKR4 PKHD1L1 SCN3A PLD5 DNAH6

2.20e-061751507f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK2 ENPP4 ACE STAC CD68 CTBS CTSD

2.37e-061771507929cd8f530ce001623735da53b7278d02522e2b5
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPYSL3 SGIP1 PKHD1L1 TENM3 SCN3A SCN9A CDH5

2.85e-06182150753c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

TRERF1 MBOAT1 DNAH10 NBEAL1 ANLN LRRTM4 EIF3C

3.07e-061841507ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 ACKR4 PKHD1L1 SCN3A TTLL1 HERC3 PLD5

3.18e-061851507bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellThalamus-Endothelial|Thalamus / BrainAtlas - Mouse McCarroll V32

TNS2 CP DYSF MSN BNIP2 DEF6 CDH5

3.29e-061861507dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DOC2A DNAH10 DNAH2 CP EFHC1 SPAG17 DNAH6

3.41e-0618715072b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SGIP1 CECR2 ABCC5 LRP1B STAC SCN2A SCN3A

3.66e-061891507975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 SGIP1 PDGFRB TNS2 PTCH1 GXYLT2

3.66e-061891507c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 SGIP1 PDGFRB TNS2 PTCH1 GXYLT2

3.92e-061911507806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellCiliated-cil-3|World / Class top

DNAH10 SYNE1 DNAH2 DNAH1 EFHC1 SPAG17 DNAH6

4.06e-0619215074989ebb8812b8af1870599acd932849122c05a29
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EZR DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

4.81e-06197150791637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EZR DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

4.81e-06197150722c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EZR DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

4.81e-0619715073bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EZR DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

4.81e-06197150787db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellCOVID-19-Myeloid|COVID-19 / group, cell type (main and fine annotations)

DOCK2 MYO9B ARHGAP26 LCP2 STAC CD68 CTSD

4.97e-06198150733f0a919188a67d2a876b52c61a1cec2c9747969
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 CP DNAH1 EFHC1 SPAG17 DNAH6

4.97e-061981507e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 CP DNAH1 EFHC1 SPAG17 DNAH6

4.97e-061981507e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NBEAL1 RHOBTB3 GNPTAB STARD10 CP ZNHIT6 RNF145

5.14e-061991507262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 CP DNAH1 EFHC1 SPAG17 DNAH6

5.31e-06200150772c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH10 DNAH2 CP DNAH1 EFHC1 SPAG17 DNAH6

5.31e-062001507da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellCOVID-19-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

ABCC5 NDUFA3 ACE CD68 ZFHX3 RNF145 CTSD

5.31e-062001507a60346c5ea7a3dae1ad3c5dc6c6eca65b64c6888
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B SCN1A FRRS1L SCN9A ROS1 USH2A

9.86e-06145150696712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB ABCG4 TENM3 PLD5

1.67e-051591506e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB ABCG4 TENM3 PLD5

1.67e-0515915062607b562903228274fbd96168ba826782fab0b53
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

IL34 ITGB4 SLITRK2 TENM3 LRRTM4 SCN9A

2.27e-0516815062fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FMO1 IMPDH1 SYNE1 ACE MSN CDH5

2.35e-05169150641ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOC2A DNAH10 DNAH1 EFHC1 SPAG17 DNAH6

2.35e-051691506fba841664939c771881ba97f14ef1df6635c04ff
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 DNAH2 ACKR4 EFHC1 SPAG17 DNAH6

2.35e-05169150614aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FMO1 IMPDH1 SYNE1 ACE MSN CDH5

2.35e-05169150642782c61592742190ab0cba8a94f8bdf9c278f90
ToppCellEndothelial-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

DPYSL3 SGIP1 DYSF PKHD1L1 SCN3A CDH5

2.59e-0517215068a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

2.68e-051731506c3762655caa79ac4879876f470d32578a3c93b01
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOC2A TRERF1 ANLN CD68 CTBS CATSPERG

2.68e-05173150626bba58f9fb215d1d155504906cd77e8774f6936
ToppCelldroplet-Lung-LUNG-1m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOC2A TRERF1 ANLN CD68 CTBS CATSPERG

2.68e-05173150669b404e92aad3e6dff67e75466f073f20a71f13f
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

ITGB4 SLITRK2 TENM3 LRRTM4 SCN9A CST5

2.68e-0517315066fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TRERF1 DNAH10 KDM5C PFKFB2 ACKR4 PIGA

2.77e-0517415062274648b80dd74f3c948a779bba3391095964c34
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 MBOAT1 PDGFRB MYO9B SYNE1 SLITRK2

2.86e-05175150612f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRERF1 SYNE1 ENPP4 SLC5A3 PLEKHG3 TGDS

2.95e-0517615065914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

DPYSL3 SGIP1 DYSF PKHD1L1 SCN3A CDH5

2.95e-051761506c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

DPYSL3 SGIP1 DYSF PKHD1L1 SCN3A CDH5

2.95e-05176150698c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellfacs-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZR HGD FMO1 CP NDUFA3 HACL1

3.05e-051771506d4cd54c07f1e51b5485270348fb7195d53465027
ToppCellCiliated_cells-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DOC2A DNAH10 DNAH2 CP SPAG17 DNAH6

3.25e-0517915060e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 SGIP1 ITGB4 HPS3 SLITRK2 ANLN

3.35e-051801506da723df348d7b8449bb1124f23fe6fa706412adb
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 SGIP1 ITGB4 HPS3 SLITRK2 ANLN

3.35e-05180150650758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCellP15-Endothelial-capillary_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FMO1 IMPDH1 RDX ACE MSN CDH5

3.35e-05180150663e7ec20a93452a02bf904acebdbe3d0d9ae8894
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOC2A DNAH10 DNAH2 DNAH1 EFHC1 SPAG17

3.35e-05180150692fb01b91261b3103454924cde56add337b41844
ToppCelldroplet-Heart-nan-3m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 SGIP1 ITGB4 HPS3 SLITRK2 ANLN

3.35e-0518015065b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CP ACKR4 PKHD1L1 ITGB4 SCN3A CDH5

3.56e-051821506d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SGIP1 PKHD1L1 TENM3 SCN3A SCN9A CDH5

3.67e-0518315064d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

3.90e-051851506f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNV2 ANXA5 LCP2 P3H4 DEF6 CTSD

3.90e-051851506aa2c36e2cce0f0a536cd1dfc3788b6fee6f21b6b
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SGIP1 PKHD1L1 TENM3 SCN3A SCN9A CDH5

4.02e-05186150640070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1B SCN2A ZFHX3 SPAG17 CTSD USH2A

4.02e-05186150623b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

SMG1 NBEAL1 GNPTAB MED14 VPS13D PBRM1

4.02e-05186150603db813598b67b1e08f759758a1c2023396921fa
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HGD TNS2 ACE PKHD1L1 ITGB4 CDH5

4.14e-05187150612129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HGD TNS2 ACE PKHD1L1 ITGB4 CDH5

4.14e-05187150683930ef55191eff9006113feaeabb3c2fa21fd05
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EZR CECR2 LRP1B SCN2A SCN3A PCCA

4.14e-05187150677886f99c229610abd28c4c370d2c7d1536c9782
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EZR ABCC5 LRP1B SCN2A SCN3A PCCA

4.14e-051871506f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYSL3 SGIP1 DYSF PKHD1L1 SCN3A CDH5

4.27e-0518815062db80767903703e7e0a1a37c598f7877a909ee94
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB PTCH1 TENM3 PLD5

4.40e-05189150671397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EZR ABCC5 LRP1B SCN2A SCN3A PCCA

4.40e-051891506e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB PTCH1 TENM3 PLD5

4.40e-0518915064eea4759520c312bd17a681034d8074e47093d2b
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL34 DPYSL3 TMEM63C CP GXYLT2 TENM3

4.40e-051891506319e42f6e2322208de78bc666fb2c074707eb4da
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

EFHC1 FRRS1L SCN2A SCN3A SCN9A ZFHX3

4.53e-0519015066e92c78799f34b31d098854503c796edb0dc7f80
ToppCellCiliated_cells-B|World / lung cells shred on cell class, cell subclass, sample id

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

4.53e-0519015067031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

4.53e-051901506426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANO2 PDGFRB ARHGAP26 SCN3A ZFHX3 CDH5

4.53e-051901506a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCelldroplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO1 IMPDH1 SYNE1 ENPP4 ACE CDH5

4.53e-051901506e64b191f928935484e2c993d7f8af0572a617a3a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 SGIP1 PDGFRB PTCH1 GXYLT2

4.66e-051911506c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL34 PDGFRB NDN ACKR4 ACE SCN3A

4.66e-051911506b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 SGIP1 PDGFRB PTCH1 GXYLT2

4.66e-051911506cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL3 SGIP1 PDGFRB NBEAL1 SCN3A ZFHX3

4.66e-05191150604c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell(12)_SLC16A7+|World / shred by cell type by condition

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

4.66e-051911506e427eeddd2e87c14376a37db0b43f120c90436bc
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO1 IMPDH1 SYNE1 ACKR4 ACE CDH5

4.80e-051921506ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO1 IMPDH1 SYNE1 ACKR4 ACE CDH5

4.80e-05192150685d4d0df701451daf95e94a87a0096da1e86533b
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 ARHGAP26 PTPRU MSN BNIP2 ZFHX3

4.80e-0519215061ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO1 IMPDH1 SYNE1 ACKR4 ACE CDH5

4.94e-0519315062218833749576ba1a0fc95bd155c781e7e1163c6
ToppCell15-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DOC2A DNAH10 DNAH2 EFHC1 SPAG17 DNAH6

4.94e-051931506aa3acc7571405169efb656d214f3a8cbf988362e
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

4.94e-051931506ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO1 IMPDH1 SYNE1 ACKR4 ACE CDH5

5.08e-051941506df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

5.08e-0519415064a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB PTCH1 TENM3 PLD5

5.08e-051941506cf0244a29934e515446ac917d3c30672b460fb04
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB PTCH1 TENM3 PLD5

5.08e-051941506e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 IL34 PDGFRB PTCH1 TENM3 PLD5

5.08e-051941506ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NBEAL1 PFKFB2 PIGA SCN1A ROS1 RNF145

5.23e-051951506d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCellMesenchymal_cells|World / Lineage and Cell class

DPYSL3 PDGFRB ANXA5 CP NDN P3H4

5.23e-051951506380eb436baa371f7aa2dc0c4a594afb173b5a25b
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH10 SYNE1 DNAH2 EFHC1 SPAG17 DNAH6

5.23e-0519515063486eae5fdb062a75a907b896c9d7b396d2aa195
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

4.62e-164615011DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 USP17L4 USP17L2 USP17L1 USP17L10 USP17L17 USP17L6P USP17L3 USP17L22 USP17L8 USP17L13

5.72e-146915011DOID:1682 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

1.32e-07101504DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

1.32e-07101504DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

3.08e-07121504DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

4.37e-06221504DOID:2030 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A

1.06e-0591503C3502809
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

2.57e-0521502C4551549
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

3.55e-05131503C0751122
DiseaseSarcomatoid Renal Cell Carcinoma

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

5.08e-051281506C1266043
DiseaseChromophobe Renal Cell Carcinoma

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

5.08e-051281506C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

5.08e-051281506C1266044
DiseasePapillary Renal Cell Carcinoma

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

5.08e-051281506C1306837
DiseaseRenal Cell Carcinoma

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

5.08e-051281506C0007134
DiseasePre-Eclampsia

ANXA5 CP ACE

6.87e-05161503C0032914
DiseaseWilson disease (biomarker_via_orthology)

ANXA5 CP

7.68e-0531502DOID:893 (biomarker_via_orthology)
Diseasemiddle cerebral artery infarction (implicated_via_orthology)

PDGFRB ACE GSK3B DNMT3A

8.13e-05451504DOID:3525 (implicated_via_orthology)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

KDM5C ASB15 LRP1B SLC5A3 PBRM1 CTSD

1.14e-041481506C0279702
DiseaseLeukemia, Myelomonocytic, Chronic

PDGFRB DNMT3A

3.80e-0461502C0023480
DiseaseManic Disorder

ME2 GSK3B SLC5A3 SCN2A

4.78e-04711504C0024713
Diseasestomach cancer (is_implicated_in)

PTCH1 ACE LRP1B DNMT3A

5.05e-04721504DOID:10534 (is_implicated_in)
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

5.30e-0471502C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

5.30e-0471502C0751057
DiseaseManic

ME2 GSK3B SLC5A3 SCN2A

6.83e-04781504C0338831
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

7.04e-0481502C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

7.04e-0481502C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

7.04e-0481502C0338479
Diseasepneumococcal meningitis

ME2 ROS1

7.04e-0481502EFO_1001114
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

7.04e-0481502C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

7.04e-0481502C0438414
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

7.04e-0481502C0393703
DiseaseDisorder of eye

AHI1 IMPDH1 KCNV2 SAG CTSD USH2A

7.77e-042121506C0015397
Diseasefacial height measurement

ANO2 LARP1 GSK3B TENM3 PLD5

8.14e-041421505EFO_0007856
DiseaseFebrile Convulsions

SCN1A SCN2A

9.03e-0491502C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

9.03e-0491502C0014550
DiseaseAutism Spectrum Disorders

TRIP12 SCN1A USH2A DNMT3A

9.44e-04851504C1510586
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

1.12e-03101502C0917800
Diseaseretinitis pigmentosa (is_implicated_in)

IMPDH1 SAG USH2A

1.19e-03411503DOID:10584 (is_implicated_in)
Diseasecocaine use

SCN1A DNMT3A

1.37e-03111502C3496069
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

1.37e-03111502C0393702
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement

DNAH10 CPT1A TGDS TNKS

1.43e-03951504EFO_0004529, EFO_0008317, EFO_0008596
Diseaseepilepsy (implicated_via_orthology)

LRP1B SCN1A SCN2A SCN3A SCN9A

1.50e-031631505DOID:1826 (implicated_via_orthology)
Diseasetriacylglycerol 58:12 measurement

MBOAT1 TRIP12

1.64e-03121502EFO_0010439
DiseaseWeight Gain

ANXA5 ACE VPS13D CTSD

1.85e-031021504C0043094
DiseaseAmyotrophic Lateral Sclerosis, Familial

FMO1 CD68 CTSD

1.88e-03481503C4551993
DiseaseAmyotrophic Lateral Sclerosis, Sporadic

FMO1 CD68 CTSD

1.88e-03481503C1862941
DiseaseKidney Failure, Chronic

CPT1A ACE CD68

1.88e-03481503C0022661
DiseaseRetinitis Pigmentosa

AHI1 IMPDH1 SAG USH2A

1.99e-031041504C0035334
Diseaselung adenocarcinoma (is_implicated_in)

PTCH1 LRP1B ZFHX3

2.00e-03491503DOID:3910 (is_implicated_in)
DiseaseIntellectual Disability

AHI1 PDGFRB SYNE1 KDM5C FARSB SCN1A SCN3A DNMT3A

2.11e-034471508C3714756
DiseaseAMYOTROPHIC LATERAL SCLEROSIS 1

FMO1 CD68 CTSD

2.12e-03501503C1862939
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

DNAH10 CPT1A TGDS TNKS

2.13e-031061504EFO_0008317, EFO_0008596
DiseaseKuhnt-Junius degeneration (is_marker_for)

PDGFRB ANXA5

2.24e-03141502DOID:10873 (is_marker_for)
DiseaseEpilepsy

KDM5C SCN1A SCN2A SCN9A

2.36e-031091504C0014544
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

DNAH10 CPT1A TGDS TNKS

2.44e-031101504EFO_0008317, EFO_0008591, EFO_0008596
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

DNAH10 CPT1A TGDS TNKS

2.44e-031101504EFO_0004574, EFO_0008317, EFO_0008596
Diseaseinterleukin 12 measurement

KCNV2 NDN RNF145

2.50e-03531503EFO_0004753
DiseaseMMR-related febrile seizures

SCN1A SCN2A

2.58e-03151502EFO_0006519
Diseaseschizophrenia (biomarker_via_orthology)

KDM5C GSK3B

2.58e-03151502DOID:5419 (biomarker_via_orthology)
Diseasecathepsin D measurement

GNPTAB CTSD

2.58e-03151502EFO_0010611
Diseasebehavior

MBOAT1 PTCH1 ZFHX3

2.78e-03551503GO_0007610
Diseaseinterferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement

PDGFRB KCNV2

2.94e-03161502EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
DiseaseAlpha ketoglutarate measurement

KCNV2 TENM3

2.94e-03161502EFO_0010457
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

2.94e-03161502C0393706
Diseasealcohol use disorder (implicated_via_orthology)

KDM5C PBRM1 BRD7 BRD9 PRKACG

3.27e-031951505DOID:1574 (implicated_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 DYSF

3.32e-03171502DOID:9884 (is_implicated_in)
DiseaseBMI-adjusted waist circumference, physical activity measurement

DNAH10 PTCH1 PBRM1 DNMT3A

3.65e-031231504EFO_0007789, EFO_0008002
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

3.72e-03181502HP_0002373
Diseasechronic obstructive pulmonary disease (is_implicated_in)

RTEL1 ACE LRP1B

4.09e-03631503DOID:3083 (is_implicated_in)
DiseaseJuvenile Myelomonocytic Leukemia

ARHGAP26 DNMT3A

4.15e-03191502C0349639
Diseasehepatocellular carcinoma (is_marker_for)

KDM5C PTCH1 LRP1B CD68 ZFHX3 DNMT3A

4.50e-033011506DOID:684 (is_marker_for)
Diseaseheart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer

DNAH2 ZFHX3

4.59e-03201502EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Diseasealpha-tocopherol measurement

SCN3A USH2A

4.59e-03201502EFO_0007898
DiseaseRetinal Degeneration

AHI1 CP

5.06e-03211502C0035304
Diseasesocial deprivation, COVID-19

CECR2 NAA20

5.06e-03211502EFO_0009696, MONDO_0100096
DiseaseInfiltrating duct carcinoma of female breast

SMG1 PDGFRB

5.06e-03211502C3165106

Protein segments in the cluster

PeptideGeneStartEntry
FYEDSKLYQLVYLMN

CATSPERG

581

Q6ZRH7
QDYIQSKIVYYLMNI

PFKFB2

231

O60825
AYYLAKTMADVPFQV

ABCG4

466

Q9H172
QATYNKQPMYRKAIY

DNMT3A

356

Q9Y6K1
RIYDYDPLYKEALQM

APOBEC3B

311

Q9UH17
EMGHIQYYLQYKDLP

ACE

391

P12821
NAMIYNKPETIYYKA

BRD7

206

Q9NPI1
NAMTYNRPDTVYYKL

BRD9

211

Q9H8M2
AQYLPKEQYLYTKEQ

AFG3L2

606

Q9Y4W6
YYEKENVDYILPIMT

AHI1

391

Q8N157
VYMAYKDLYQVSNTE

DPYSL3

166

Q14195
IPELQEYVKYKYAMD

ASB15

56

Q8WXK1
NSNYYAMDLLYILPT

CPT1A

251

P50416
AVMALAYYNYEDLPK

ACOT2

246

P49753
AYYNYEDLPKTMETL

ACOT2

251

P49753
GYVKYSIFQLVMQYL

BTBD11

966

A6QL63
VVLYSSDYYVKPVAM

SAG

251

P10523
SIPAYLAETLYYAMK

ANXA5

246

P08758
NLSYPFSREKMYLYN

ANO2

251

Q9NQ90
LSPAAYYAQRMIQYL

AMBRA1

721

Q9C0C7
PYNQTLTGYNDYIKM

CTBS

226

Q01459
PMKPLDYEYIQQYSF

CDH5

321

P33151
SYAPNYYQIIKAPMD

CECR2

466

Q9BXF3
LQSIVPLFIYMNKFY

CACUL1

221

Q86Y37
IEKYIVPYMKQYEAH

NBEAL1

1686

Q6ZS30
PQYMIDLYNRYTSDK

GDF2

86

Q9UK05
KSLPMNYYTVFYHVQ

HACL1

371

Q9UJ83
QYLPFSNKEYEISML

NUP205

1096

Q92621
YLKIAQDLEMYGVNY

RDX

191

P35241
LAGNSMVVAIYAYYK

ACKR4

56

Q9NPB9
DDKVYPGEQYTYMLL

CP

146

P00450
LQQKVVYLSYMAVEY

CD68

231

P34810
TPKYMNNITYYFDNV

LARP1

376

Q6PKG0
KYPDYYQQIKMPISL

PBRM1

416

Q86U86
LYYPQMLYIRKISNI

PRAMEF17

266

Q5VTA0
NYSNPVYAKLYMDGQ

LRP1B

4556

Q9NZR2
QMNSPLQEYYVDYKP

LRRTM4

476

Q86VH4
SYFYYLMSAVQPLNI

GNPTAB

996

Q3T906
KELLNPIYGMFTYYQ

HERC3

756

Q15034
LAPQYVMYGSQNYLI

LMBRD1

431

Q9NUN5
TVQKPDAANYYYLII

ANLN

821

Q9NQW6
RYNMYYSFAPTKLNE

TMEM63C

636

Q9P1W3
NMYKQLGYSVYRTVI

NAA20

121

P61599
IIYMYLQPANTYSQD

OR2W6P

261

Q8NHA6
MNVYLKEDIPNRFYY

ENPP4

291

Q9Y6X5
YMKYLRQKNIPFYIS

GLYATL1

251

Q969I3
DMLYPLYQKYKNAIT

GXYLT2

296

A0PJZ3
FQSMYYPLQLKFLET

GXYLT2

391

A0PJZ3
YLKIAQDLEMYGVNY

MSN

191

P26038
ISIYYDPMISKLITY

PCCA

441

P05165
VELTNLYPYCDYEMK

ITGB4

1181

P16144
VYQIAMVHYIKQKYP

IMPDH1

281

P20839
PTQLSYKYYFMSVNA

MED14

561

O60244
YYPKPVNMTKATVNY

PTPRU

781

Q92729
IYNYMLPSSYQTPEK

OR2T10

256

Q8NGZ9
KDNPHMQYYASIYAL

ABCC5

906

O15440
YILNMLFNLPETYLY

NT5DC4

121

Q86YG4
SLYDYNPNLATYMKP

EIF3C

381

Q99613
GMYEAVNYYVLNPKS

DNAH1

1891

Q9P2D7
ASLYDYNPNLATYMK

EIF3CL

381

B5ME19
IDPMYQYSLKYFKQL

DNAH6

3311

Q9C0G6
LQYMKHYFPINYKIS

IL34

51

Q6ZMJ4
FKDNSYLYLVMEYVP

PRKACG

111

P22612
MDVNGYSDPYVKTYL

DOC2A

281

Q14183
KPMNEYRSVVYYQVK

DOCK2

471

Q92608
MYTYYTLKAANVKPP

ELOVL3

181

Q9HB03
IYKYEDIFMPSAAYQ

FRRS1L

256

Q9P0K9
PIPEVLKNYMDAQYY

CTSD

66

P07339
YVPNSQFLEYLKMYA

FMO1

81

Q01740
DVKQVMPDQRVIYYY

CENPJ

1196

Q9HC77
MPDQRVIYYYAAAQT

CENPJ

1201

Q9HC77
QTLPVIYVKLYMYQL

GSK3B

151

P49841
KIEYMQQNLVRYYEL

ZNHIT6

406

Q9NWK9
YPNNYETMKILGSLY

CTR9

371

Q6PD62
KDEYYSRPLQVMAAY

CST5

61

P28325
PNYRYLMDNLFKYVI

BNIP2

181

Q12982
QGYMPYLNKYILDKV

DEF6

66

Q9H4E7
VEPTISLYKSMYFYL

MBOAT1

446

Q6ZNC8
TEYLYANKMAFRYPE

ME2

531

P23368
ATLLESYQVYKRYQM

ATE1

286

O95260
YVLKYMESNAAQYSP

EFHC1

511

Q5JVL4
YLKIAQDLEMYGINY

EZR

191

P15311
VTLVKYFPQAYMNFY

CTNS

276

O60931
NLNSLFEKYVPYLMD

DNAH10

2276

Q8IVF4
YKIMVPTVDTVRYNY

DNAH2

2386

Q9P225
FVKVYNYNHLMPTRY

RPL27

71

P61353
AIFIYAFPNYAAMKL

DYSF

2061

O75923
QMEVKPYNVYITVAY

KDSR

201

Q06136
VKYADIESSNYMAPY

PDGFRB

761

P09619
PSNMYLKQLAEYRKY

RHOBTB3

586

O94955
NYTPYKYNLKNFMVI

HGD

271

Q93099
KQQADIIFMPYNYLL

RTEL1

216

Q9NZ71
VNTYSYTDVNLKPYM

USH2A

3456

O75445
ADYIIMNYSVKHPKY

STARD10

141

Q9Y365
AKQYVYIAVMDYLPI

PLD5

336

Q8N7P1
YEVTYQILKQTAEMY

SYNE1

556

Q8NF91
EAYYYMLGPAKETNI

TMEM161A

121

Q9NX61
VVYLVTEVYYNFMKP

TMEM161B

116

Q8NDZ6
PVQLYKEMVDYSNTY

HPS3

496

Q969F9
KEAILEMDSYYPNRY

PLEKHG3

406

A1L390
GQPLAIYYLAKMYAT

SEL1L2

441

Q5TEA6
SPALLMQQFYNETYY

SLC2A5

41

P22732
GMPISILYNKFSDYY

KCNV2

486

Q8TDN2
QELYRKYEMQYAPQP

SMG1

2681

Q96Q15
KTISPYTMEGYLYVQ

ARHGAP26

261

Q9UNA1
YNMYIVTQKADYPNI

PTCH1

801

Q13635
VDKQPKYEYSLYMYI

SCN9A

1421

Q15858
YMQKEGDPVAYYRNL

SLITRK2

701

Q9H156
QMYLYIQEVADYLTP

SLC5A3

436

P53794
DVKLQPVYEENLYMY

SCN3A

1431

Q9NY46
RVYMPCLYVYNKIDQ

DRG2

236

P55039
SRKMQASPEYQDYVY

ARHGAP35

296

Q9NRY4
AYGYNNIQMTLPKTY

FARSB

371

Q9NSD9
TTEVDMRYYNYLLNP

SPAG17

421

Q6Q759
NVELQPKYEESLYMY

SCN1A

1446

P35498
LGIYMTYSPKVYSVN

CLEC20A

251

Q6ZU45
KDYTQVDYLINGMYA

C11orf24

431

Q96F05
LKSAYENNLMPYTNY

CNOT6L

466

Q96LI5
GLKVYYLPLKVMYNQ

PIGA

86

P37287
YPNYMIINLDKLDYC

TGDS

41

O95455
MQLSFTQLTIDYYPY

UHRF1BP1L

351

A0JNW5
YMSQQNTGPLVYVLY

USP17L3

306

A6NCW0
YPMAYVDYKTVLQID

TOMM34

101

Q15785
YMSQQNTGPLVYVLY

USP17L4

306

A6NCW7
ATYYNVDMLKYQVSA

SGIP1

666

Q9BQI5
ELTAKYLNYYQGMLD

P3H4

176

Q92791
YPEYLITYQIMKPEA

TNKS

1301

O95271
QMNTYVALYKFVPQE

STAC

286

Q99469
NVELQPKYEDNLYMY

SCN2A

1436

Q99250
LEMYSISRKYDYQQP

SMIM19

81

Q96E16
YMSQQNTGPLVYVLY

USP17L13

306

C9JLJ4
NLVIYLQRYMDPSTY

SLC35A4

101

Q96G79
LMLKQIQYTAYGEIY

TENM3

2311

Q9P273
YMIQIAVKNYYSDPL

ROS1

1526

P08922
YMSQQNTGPLVYVLY

USP17L1

306

Q7RTZ2
NYFDGTYQMLYLLVK

PKHD1L1

3911

Q86WI1
YSVMINKATPYNYPV

NDUFA3

41

O95167
YMSQQNTGPLVYVLY

USP17L7

306

P0C7H9
YMSQQNTGPLVYVLY

USP17L8

306

P0C7I0
IPSFERYMAQLKCYY

PSMD8

161

P48556
YMSQQNTGPLVYVLY

USP17L6P

306

Q6QN14
YMSQQNTGPLVYVLY

USP17L22

306

D6RA61
YYLYDNAMCKEIIPT

TRIP12

1486

Q14669
NPLFQYKYLALNMHY

RNF145

46

Q96MT1
YMSQQNTGPLVYVLY

USP17L17

306

D6RBQ6
FQPFLKIYQSMQLVY

TNS2

321

Q63HR2
KIYQSMQLVYTSGVY

TNS2

326

Q63HR2
YMSQQNTGPLVYVLY

USP17L2

306

Q6R6M4
NGKYLYLDFVPVTYM

TTLL1

101

O95922
YMSQQNTGPLVYVLY

USP17L10

306

C9JJH3
PAEAELYQYYLAQNM

ZFHX3

856

Q15911
VQLIPLGSMSQYYYQ

TRERF1

366

Q96PN7
INYAKSLYYEQQLML

VPS13D

4361

Q5THJ4
VYPYEMYQSGANLVQ

KDM5C

161

P41229
TNPYVLMVLYKDKVY

LCP2

456

Q13094
FLPIYNPKYVKMYDN

MYO9A

191

B2RTY4
FLPIYNPKYVKMYEN

MYO9B

191

Q13459
QMNYLKYQRVPYVEP

NDN

241

Q99608