Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	1.16e-05	5	22	2	GO:0071558
GeneOntologyMolecularFunction	histone modifying activity	MIER2 KDM6A UTY MIER3	1.05e-04	229	22	4	GO:0140993
GeneOntologyMolecularFunction	histone deacetylase activity	MIER2 MIER3	3.15e-04	24	22	2	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	MIER2 MIER3	3.42e-04	25	22	2	GO:0033558
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM6A UTY	4.30e-04	28	22	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM6A UTY	5.28e-04	31	22	2	GO:0032452
GeneOntologyMolecularFunction	histone deacetylase binding	MIER2 MIER3 DNMT1	5.43e-04	147	22	3	GO:0042826
GeneOntologyMolecularFunction	protein demethylase activity	KDM6A UTY	5.63e-04	32	22	2	GO:0140457
GeneOntologyMolecularFunction	deacetylase activity	MIER2 MIER3	8.81e-04	40	22	2	GO:0019213
GeneOntologyMolecularFunction	demethylase activity	KDM6A UTY	1.07e-03	44	22	2	GO:0032451
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM6A UTY	2.31e-03	65	22	2	GO:0016706
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	MIER2 MIER3	3.56e-03	81	22	2	GO:0016811
GeneOntologyMolecularFunction	dioxygenase activity	KDM6A UTY	5.17e-03	98	22	2	GO:0051213
GeneOntologyMolecularFunction	metalloendopeptidase activity	MMP15 MMP24	7.65e-03	120	22	2	GO:0004222
GeneOntologyBiologicalProcess	RNA splicing	SUGP2 RBM5 PRPF39 RBM10 TGS1	1.23e-04	502	21	5	GO:0008380
GeneOntologyBiologicalProcess	mRNA processing	SUGP2 RBM5 PRPF39 RBM10 TGS1	1.91e-04	551	21	5	GO:0006397
GeneOntologyBiologicalProcess	regulation of vascular associated smooth muscle cell apoptotic process	RBM10 DNMT1	2.47e-04	23	21	2	GO:1905459
GeneOntologyBiologicalProcess	vascular associated smooth muscle cell apoptotic process	RBM10 DNMT1	2.47e-04	23	21	2	GO:1905288
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBM5 PRPF39 RBM10 TGS1	4.23e-04	358	21	4	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBM5 PRPF39 RBM10 TGS1	4.23e-04	358	21	4	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBM5 PRPF39 RBM10 TGS1	4.41e-04	362	21	4	GO:0000375
GeneOntologyBiologicalProcess	regulation of smooth muscle cell apoptotic process	RBM10 DNMT1	9.95e-04	46	21	2	GO:0034391
GeneOntologyBiologicalProcess	smooth muscle cell apoptotic process	RBM10 DNMT1	1.04e-03	47	21	2	GO:0034390
GeneOntologyBiologicalProcess	collagen catabolic process	MMP15 MMP24	1.32e-03	53	21	2	GO:0030574
GeneOntologyBiologicalProcess	ribonucleoprotein complex biogenesis	RBM5 PRPF39 RBM10 TGS1	1.64e-03	515	21	4	GO:0022613
GeneOntologyBiologicalProcess	protein-RNA complex assembly	RBM5 PRPF39 TGS1	1.86e-03	244	21	3	GO:0022618
GeneOntologyBiologicalProcess	mRNA metabolic process	SUGP2 RBM5 PRPF39 RBM10 TGS1	1.93e-03	917	21	5	GO:0016071
GeneOntologyBiologicalProcess	protein-RNA complex organization	RBM5 PRPF39 TGS1	2.08e-03	254	21	3	GO:0071826
GeneOntologyCellularComponent	MLL3/4 complex	KDM6A UTY	6.93e-05	12	22	2	GO:0044666
Domain	G_patch	SUGP2 RBM5 RBM10	2.14e-06	23	21	3	SM00443
Domain	G_patch_dom	SUGP2 RBM5 RBM10	2.14e-06	23	21	3	IPR000467
Domain	G_PATCH	SUGP2 RBM5 RBM10	2.14e-06	23	21	3	PS50174
Domain	G-patch	SUGP2 RBM5 RBM10	2.14e-06	23	21	3	PF01585
Domain	DUF3377	MMP15 MMP24	7.21e-06	4	21	2	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP15 MMP24	7.21e-06	4	21	2	IPR021805
Domain	TPR_8	DNAJC7 KDM6A UTY	2.77e-05	53	21	3	PF13181
Domain	-	RBM5 RBM10	5.39e-05	10	21	2	4.10.1060.10
Domain	-	DNAJC7 PRPF39 KDM6A UTY	7.57e-05	207	21	4	1.25.40.10
Domain	ELM2	MIER2 MIER3	9.32e-05	13	21	2	PF01448
Domain	ELM2	MIER2 MIER3	9.32e-05	13	21	2	PS51156
Domain	ELM2_dom	MIER2 MIER3	9.32e-05	13	21	2	IPR000949
Domain	ELM2	MIER2 MIER3	9.32e-05	13	21	2	SM01189
Domain	TPR-like_helical_dom	DNAJC7 PRPF39 KDM6A UTY	1.20e-04	233	21	4	IPR011990
Domain	TPR_1	DNAJC7 KDM6A UTY	1.35e-04	90	21	3	PF00515
Domain	TPR_1	DNAJC7 KDM6A UTY	1.35e-04	90	21	3	IPR001440
Domain	Hemopexin_CS	MMP15 MMP24	1.62e-04	17	21	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP15 MMP24	1.82e-04	18	21	2	IPR016293
Domain	Peptidoglycan-bd-like	MMP15 MMP24	2.26e-04	20	21	2	IPR002477
Domain	PG_binding_1	MMP15 MMP24	2.26e-04	20	21	2	PF01471
Domain	zf-RanBP	RBM5 RBM10	2.74e-04	22	21	2	PF00641
Domain	HEMOPEXIN	MMP15 MMP24	3.00e-04	23	21	2	PS00024
Domain	-	MMP15 MMP24	3.00e-04	23	21	2	2.110.10.10
Domain	Hemopexin-like_dom	MMP15 MMP24	3.00e-04	23	21	2	IPR000585
Domain	HEMOPEXIN_2	MMP15 MMP24	3.00e-04	23	21	2	PS51642
Domain	ZnF_RBZ	RBM5 RBM10	3.00e-04	23	21	2	SM00547
Domain	Hemopexin-like_repeat	MMP15 MMP24	3.00e-04	23	21	2	IPR018487
Domain	Hemopexin	MMP15 MMP24	3.00e-04	23	21	2	PF00045
Domain	HX	MMP15 MMP24	3.00e-04	23	21	2	SM00120
Domain	Pept_M10A	MMP15 MMP24	3.00e-04	23	21	2	IPR021190
Domain	ZF_RANBP2_2	RBM5 RBM10	3.00e-04	23	21	2	PS50199
Domain	M10A_MMP	MMP15 MMP24	3.00e-04	23	21	2	IPR033739
Domain	ZF_RANBP2_1	RBM5 RBM10	3.27e-04	24	21	2	PS01358
Domain	JmjC	KDM6A UTY	3.27e-04	24	21	2	PF02373
Domain	Peptidase_M10	MMP15 MMP24	3.27e-04	24	21	2	PF00413
Domain	Znf_RanBP2	RBM5 RBM10	3.56e-04	25	21	2	IPR001876
Domain	SANT_dom	MIER2 MIER3	3.85e-04	26	21	2	IPR017884
Domain	TPR	DNAJC7 KDM6A UTY	3.91e-04	129	21	3	SM00028
Domain	TPR_repeat	DNAJC7 KDM6A UTY	4.27e-04	133	21	3	IPR019734
Domain	SANT	MIER2 MIER3	4.47e-04	28	21	2	PS51293
Domain	ZnMc	MMP15 MMP24	4.80e-04	29	21	2	SM00235
Domain	Peptidase_Metallo	MMP15 MMP24	4.80e-04	29	21	2	IPR006026
Domain	JMJC	KDM6A UTY	5.85e-04	32	21	2	PS51184
Domain	JmjC_dom	KDM6A UTY	5.85e-04	32	21	2	IPR003347
Domain	TPR-contain_dom	DNAJC7 KDM6A UTY	6.07e-04	150	21	3	IPR013026
Domain	JmjC	KDM6A UTY	6.23e-04	33	21	2	SM00558
Domain	TPR	DNAJC7 KDM6A UTY	8.01e-04	165	21	3	PS50005
Domain	TPR_REGION	DNAJC7 KDM6A UTY	8.01e-04	165	21	3	PS50293
Domain	CYSTEINE_SWITCH	MMP15 MMP24	9.62e-04	41	21	2	PS00546
Domain	Pept_M10_metallopeptidase	MMP15 MMP24	1.06e-03	43	21	2	IPR001818
Domain	SANT	MIER2 MIER3	1.43e-03	50	21	2	SM00717
Domain	SANT/Myb	MIER2 MIER3	1.54e-03	52	21	2	IPR001005
Domain	-	MMP15 MMP24	3.70e-03	81	21	2	3.40.390.10
Domain	MetalloPept_cat_dom	MMP15 MMP24	3.70e-03	81	21	2	IPR024079
Domain	ZINC_PROTEASE	MMP15 MMP24	5.36e-03	98	21	2	PS00142
Domain	Homeodomain-like	MIER2 ZHX1 MIER3	5.84e-03	332	21	3	IPR009057
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP15 MMP24	5.45e-04	29	17	2	MM15981
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM6A UTY	5.45e-04	29	17	2	MM14934
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP15 MMP24	5.84e-04	30	17	2	M39652
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	MMP15 MMP24	7.07e-04	33	17	2	M26976
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	MMP15 MMP24	9.38e-04	38	17	2	MM14611
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP15 MMP24	1.37e-03	46	17	2	M46450
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM6A UTY	1.62e-03	50	17	2	M27232
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	DNAJC7 LARS2 RBM5 PRPF39 RBM10 SIPA1L1	5.64e-09	232	22	6	25515538
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	3.82e-07	2	22	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	3.82e-07	2	22	2	31097364
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	3.82e-07	2	22	2	18434530
Pubmed	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	RBM5 RBM10	3.82e-07	2	22	2	28662214
Pubmed	Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.	RBM5 RBM10	3.82e-07	2	22	2	28586478
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	3.82e-07	2	22	2	27533081
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	3.82e-07	2	22	2	8944031
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SUGP2 RBM5 PRPF39 RBM10 SIPA1L1	6.91e-07	274	22	5	34244482
Pubmed	Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.	RBM5 RBM10	1.15e-06	3	22	2	26784654
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	1.15e-06	3	22	2	9499428
Pubmed	RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.	RBM5 RBM10	2.29e-06	4	22	2	24332178
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM6A UTY	2.29e-06	4	22	2	32732223
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	KDM6A UTY	2.29e-06	4	22	2	10767340
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	KDM6A UTY	2.29e-06	4	22	2	9854018
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP15 MMP24	2.29e-06	4	22	2	35062057
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP15 MMP24	3.82e-06	5	22	2	12661033
Pubmed	Differential HDAC1 and 2 Recruitment by Members of the MIER Family.	MIER2 MIER3	3.82e-06	5	22	2	28046085
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP15 MMP24	3.82e-06	5	22	2	29196321
Pubmed	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat.	KDM6A DNMT1	5.72e-06	6	22	2	34824202
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SUGP2 KDM6A ZHX1 RBM10 SIPA1L1 DNMT1	6.56e-06	774	22	6	15302935
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP15 MMP24	8.01e-06	7	22	2	25794647
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	KDM6A UTY	8.01e-06	7	22	2	29551674
Pubmed	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.	KDM6A UTY	1.07e-05	8	22	2	36412518
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	KDM6A UTY	1.37e-05	9	22	2	23028370
Pubmed	UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.	KDM6A UTY	1.37e-05	9	22	2	22949634
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DNAJC7 MIER2 SUGP2 RBM10 SIPA1L1	1.81e-05	536	22	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DNAJC7 MIER2 SUGP2 RBM10 SIPA1L1	1.84e-05	538	22	5	10512203
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	DNAJC7 SUGP2 KDM6A RBM10 DNMT1	2.03e-05	549	22	5	38280479
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM6A UTY	2.97e-05	13	22	2	14660691
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	KDM6A UTY	2.97e-05	13	22	2	22192413
Pubmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	DCAF5 DNMT1	3.99e-05	15	22	2	29691401
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP15 MMP24	4.56e-05	16	22	2	10949577
Pubmed	Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects.	LARS2 SIPA1L1	4.56e-05	16	22	2	36092713
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	KDM6A UTY	4.56e-05	16	22	2	35212626
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SUGP2 RBM5 PRPF39 KDM6A RBM10 DNMT1	4.84e-05	1103	22	6	34189442
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM6A UTY	5.81e-05	18	22	2	12023983
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KDM6A UTY	7.21e-05	20	22	2	19047629
Pubmed	Matrix metalloproteinases.	MMP15 MMP24	8.76e-05	22	22	2	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP15 MMP24	8.76e-05	22	22	2	23421805
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP15 MMP24	1.05e-04	24	22	2	15734845
Pubmed	Functional coherence of the human Y chromosome.	KDM6A UTY	1.14e-04	25	22	2	9381176
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SUGP2 DCAF5 RBM10 SIPA1L1	1.14e-04	407	22	4	12693553
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MIER2 KDM6A UTY RBM10 DNMT1	1.27e-04	808	22	5	20412781
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KDM6A RBM10	1.76e-04	31	22	2	20516061
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM6A DNMT1	1.99e-04	33	22	2	26864203
Pubmed	Human transcription factor protein interaction networks.	DNAJC7 SUGP2 KDM6A ZHX1 DCAF5 RBM10	2.01e-04	1429	22	6	35140242
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	MMP15 MMP24	2.38e-04	36	22	2	20587546
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	DNAJC7 SUGP2	2.38e-04	36	22	2	35379950
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DNAJC7 SUGP2 RBM5 RBM10 DNMT1	3.24e-04	989	22	5	36424410
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SUGP2 KDM6A RBM10	3.52e-04	220	22	3	35785414
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM6A DNMT1	3.56e-04	44	22	2	24183668
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	MIER2 MIER3	3.72e-04	45	22	2	21258344
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM6A UTY	4.41e-04	49	22	2	34368113
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KDM6A UTY	4.59e-04	50	22	2	37974198
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	RBM5 KDM6A RBM10	5.17e-04	251	22	3	31076518
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	SUGP2 ZHX1 RBM10 TGS1	5.27e-04	608	22	4	16713569
Pubmed	A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.	SUGP2 RBM5 RBM10	5.35e-04	254	22	3	28431233
Interaction	FBXW11 interactions	DNAJC7 LARS2 RBM5 PRPF39 RBM10 SIPA1L1	6.51e-06	473	21	6	int:FBXW11
Interaction	GLDC interactions	SUGP2 RBM5 PRPF39 RBM10 SIPA1L1	1.64e-05	321	21	5	int:GLDC
Cytoband	3p21.3	LARS2 RBM5	3.69e-04	59	22	2	3p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	DCAF5 SIPA1L1	4.12e-03	200	22	2	chr14q24
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MIER2 SUGP2 DNMT1	6.28e-03	797	22	3	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	LARS2 RBM5	9.96e-03	316	22	2	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	KDM6A RBM10	1.39e-02	377	22	2	chrXp11
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	SUGP2 RBM5 RBM10	1.26e-06	22	18	3	579
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	DNAJC7 KDM6A UTY	1.91e-04	115	18	3	769
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RBM5 RBM10	1.94e-04	21	18	2	89
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP15 MMP24	2.55e-04	24	18	2	891
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A UTY	2.55e-04	24	18	2	485
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIER2 MIER3	1.25e-03	53	18	2	532
GeneFamily	RNA binding motif containing	RBM5 RBM10	1.87e-02	213	18	2	725
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000	RBM5 KDM6A UTY SFI1 MIER3 TGS1	9.43e-05	801	21	6	gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	RBM5 KDM6A SFI1 MIER3	1.38e-04	275	21	4	gudmap_developingGonad_e14.5_ epididymis_1000_k3
ToppCell	E16.5-samps\|World / Age Group, Lineage, Cell class and subclass	RBM5 UTY DNMT1	5.23e-05	149	22	3	e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	KDM6A UTY SFI1	6.71e-05	162	22	3	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	KDM6A UTY SFI1	9.32e-05	181	22	3	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KDM6A UTY SFI1	1.11e-04	192	22	3	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MMP15 SSUH2 TGS1	1.23e-04	199	22	3	7271dbeca9aa838b88ad44d00059263a29c0316b
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SUGP2 UTY SFI1	1.23e-04	199	22	3	f0b0097df0026496470a80d8cc9375ffd8389b00
Drug	diacerein	MMP15 MMP24 GNS	2.59e-05	63	21	3	CID000026248
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	LARS2 MMP15 RBM10 SFI1	2.68e-05	193	21	4	3262_UP
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	SUGP2 KDM6A UTY SIPA1L1	2.79e-05	195	21	4	4106_DN
Drug	genistein; Up 200; 10uM; MCF7; HT_HG-U133A	MMP15 RBM5 RBM10 SFI1	2.84e-05	196	21	4	5232_UP
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A	MMP15 KDM6A UTY SIPA1L1	2.84e-05	196	21	4	4984_DN
Drug	deferoxamine mesylate salt; Down 200; 100uM; PC3; HG-U133A	SUGP2 RBM10 SSUH2 TGS1	2.90e-05	197	21	4	460_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	RBM5 KDM6A MMP24 SFI1	2.90e-05	197	21	4	3859_UP
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	SUGP2 MMP15 UTY GNS	2.90e-05	197	21	4	4829_DN
Drug	(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; MCF7; HT_HG-U133A	MIER2 RBM5 SFI1 TGS1	2.96e-05	198	21	4	2772_UP
Drug	Bethanechol chloride [590-63-6]; Up 200; 20.4uM; MCF7; HT_HG-U133A	RBM5 KDM6A MMP24 SIPA1L1	2.96e-05	198	21	4	3537_UP
Drug	Urapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; MCF7; HT_HG-U133A	RBM5 KDM6A RBM10 SFI1	2.96e-05	198	21	4	5295_UP
Drug	sodium 4-phenylbutyrate; Up 200; 1000uM; MCF7; HG-U133A	SUGP2 RBM5 UTY RBM10	3.02e-05	199	21	4	408_UP
Drug	arachidonic acid sodium salt; Down 200; 10uM; MCF7; HG-U133A	SUGP2 KDM6A UTY GNS	3.08e-05	200	21	4	604_DN
Drug	MMI270	MMP15 MMP24	1.23e-04	18	21	2	CID000446504
Drug	Pro-leu-gly	MMP15 MMP24	2.60e-04	26	21	2	CID000169533
Drug	DA-125	MMP15 MMP24	2.60e-04	26	21	2	CID000114758
Drug	mercuric acetate	MMP15 MMP24	3.47e-04	30	21	2	CID000015337
Drug	malolactomycin D	MMP15 MMP24	3.95e-04	32	21	2	CID006449115
Drug	1ct8	DNAJC7 RBM5 C1GALT1C1	5.18e-04	173	21	3	CID000444888
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	DNAJC7 RBM5 SIPA1L1	5.54e-04	177	21	3	6340_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	DNAJC7 RBM5 RBM10	5.73e-04	179	21	3	5822_DN
Drug	Ellipticine [519-23-3]; Down 200; 16.2uM; PC3; HT_HG-U133A	RBM5 KDM6A TGS1	5.82e-04	180	21	3	5779_DN
Drug	succinimide	GNS TGS1	5.88e-04	39	21	2	CID000011439
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A	RBM5 RBM10 SIPA1L1	6.01e-04	182	21	3	1891_DN
Drug	latanoprost acid	MMP15 MMP24	6.19e-04	40	21	2	CID006441636
Drug	lomustine; Up 200; 100uM; MCF7; HT_HG-U133A	KDM6A GNS TGS1	6.30e-04	185	21	3	7045_UP
Drug	trichostatin A; Down 200; 0.1uM; PC3; HG-U133A	RBM5 RBM10 SIPA1L1	6.50e-04	187	21	3	448_DN
Drug	Cyclosporin A [59865-13-3]; Up 200; 3.4uM; HL60; HT_HG-U133A	SIPA1L1 SFI1 TGS1	6.71e-04	189	21	3	1331_UP
Drug	Betazole hydrochloride; Up 200; 27uM; HL60; HT_HG-U133A	RBM5 UTY SIPA1L1	6.91e-04	191	21	3	1854_UP
Drug	prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	KDM6A RBM10 SIPA1L1	6.91e-04	191	21	3	6586_UP
Drug	Beclomethasone dipropionate [5534-09-8]; Up 200; 7.6uM; PC3; HT_HG-U133A	UTY SFI1 TGS1	6.91e-04	191	21	3	4580_UP
Drug	2-propylpentanoic acid; Down 200; 1000uM; PC3; HG-U133A	RBM10 SIPA1L1 SSUH2	7.02e-04	192	21	3	458_DN
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; PC3; HT_HG-U133A	SUGP2 RBM5 KDM6A	7.02e-04	192	21	3	7378_DN
Drug	rosiglitazone; Up 200; 10uM; HL60; HT_HG-U133A	MMP24 SIPA1L1 SFI1	7.02e-04	192	21	3	1174_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	MMP15 UTY SFI1	7.13e-04	193	21	3	5584_DN
Drug	AG-028671 [847803-03-6]; Up 200; 10uM; MCF7; HT_HG-U133A	RBM5 KDM6A GNS	7.13e-04	193	21	3	6587_UP
Drug	Imipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SUGP2 SIPA1L1 SFI1	7.13e-04	193	21	3	5440_DN
Drug	C768-0445; Down 200; 10uM; MCF7; HT_HG-U133A_EA	LARS2 SUGP2 TGS1	7.13e-04	193	21	3	865_DN
Drug	ICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A	SUGP2 UTY SIPA1L1	7.23e-04	194	21	3	7534_DN
Drug	Nilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A	RBM5 UTY SFI1	7.23e-04	194	21	3	5362_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	GNS SFI1 TGS1	7.23e-04	194	21	3	7044_UP
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	MMP15 SIPA1L1 TGS1	7.23e-04	194	21	3	3321_DN
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; PC3; HT_HG-U133A	DNAJC7 SUGP2 UTY	7.23e-04	194	21	3	5854_DN
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	RBM5 KDM6A UTY	7.23e-04	194	21	3	4727_DN
Drug	17-AAG; Up 200; 1uM; SKMEL5; HG-U133A	DNAJC7 RBM5 UTY	7.23e-04	194	21	3	505_UP
Drug	Nocodazole [31430-18-9]; Up 200; 13.2uM; PC3; HT_HG-U133A	SUGP2 KDM6A UTY	7.23e-04	194	21	3	2076_UP
Drug	Lynestrenol [52-76-6]; Up 200; 14uM; MCF7; HT_HG-U133A	UTY SIPA1L1 SFI1	7.23e-04	194	21	3	5355_UP
Drug	radicicol; Down 200; 0.1uM; PC3; HT_HG-U133A	UTY SFI1 TGS1	7.23e-04	194	21	3	5952_DN
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	RBM5 PRPF39 UTY	7.34e-04	195	21	3	3721_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	SIPA1L1 SFI1 TGS1	7.34e-04	195	21	3	3173_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	RBM5 GNS SFI1	7.34e-04	195	21	3	3862_UP
Drug	Chlorthalidone [77-36-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	KDM6A UTY RBM10	7.34e-04	195	21	3	7152_DN
Drug	sodium 4-phenylbutyrate; Down 200; 1000uM; PC3; HG-U133A	SUGP2 RBM10 SIPA1L1	7.34e-04	195	21	3	434_DN
Drug	Tiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A	MMP15 KDM6A UTY	7.34e-04	195	21	3	4686_DN
Drug	Lobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SUGP2 MMP15 SFI1	7.34e-04	195	21	3	2897_UP
Drug	Salsolinol hydrobromide [38221-21-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	MMP15 UTY GNS	7.34e-04	195	21	3	2791_DN
Drug	Panthenol (D) [81-13-0]; Up 200; 19.4uM; HL60; HT_HG-U133A	SUGP2 GNS SFI1	7.34e-04	195	21	3	1844_UP
Drug	Cefmetazole sodium salt [56796-39-5]; Down 200; 8.2uM; PC3; HT_HG-U133A	SUGP2 RBM5 RBM10	7.45e-04	196	21	3	5868_DN
Drug	Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A	SUGP2 MMP15 KDM6A	7.45e-04	196	21	3	6260_UP
Drug	monastrol; Down 200; 100uM; MCF7; HG-U133A	RBM5 RBM10 SFI1	7.45e-04	196	21	3	610_DN
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; HL60; HG-U133A	SUGP2 GNS SFI1	7.45e-04	196	21	3	1987_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	RBM5 KDM6A SFI1	7.45e-04	196	21	3	5830_DN
Drug	GSK-3beta Inhibitor VIII; Up 200; 10uM; MCF7; HT_HG-U133A	MIER2 SUGP2 MMP15	7.45e-04	196	21	3	7092_UP
Drug	Mifepristone [84371-65-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MMP15 SFI1 TGS1	7.45e-04	196	21	3	7183_DN
Drug	Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; HL60; HT_HG-U133A	SUGP2 GNS TGS1	7.45e-04	196	21	3	1276_UP
Drug	Liothyronine [6893-02-3]; Down 200; 6.2uM; MCF7; HT_HG-U133A	SUGP2 KDM6A SIPA1L1	7.45e-04	196	21	3	3324_DN
Drug	Hymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A	MMP15 SIPA1L1 SFI1	7.45e-04	196	21	3	3383_DN
Drug	Mebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; PC3; HT_HG-U133A	UTY GNS TGS1	7.45e-04	196	21	3	7147_DN
Drug	Praziquantel [55268-74-1]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MMP15 KDM6A TGS1	7.45e-04	196	21	3	7228_DN
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; HL60; HT_HG-U133A	SIPA1L1 SFI1 TGS1	7.56e-04	197	21	3	1296_UP
Drug	Clemastine fumarate [14976-57-9]; Down 200; 8.6uM; HL60; HT_HG-U133A	UTY SIPA1L1 TGS1	7.56e-04	197	21	3	2412_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SUGP2 SIPA1L1 SFI1	7.56e-04	197	21	3	6222_DN
Drug	Oleandomycin phosphate [7060-74-4]; Down 200; 5uM; MCF7; HT_HG-U133A	SUGP2 SIPA1L1 SFI1	7.56e-04	197	21	3	1518_DN
Drug	Glibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A	SUGP2 MMP15 KDM6A	7.56e-04	197	21	3	7202_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SUGP2 GNS SFI1	7.56e-04	197	21	3	7185_DN
Drug	Triflusal [322-79-2]; Down 200; 16.2uM; HL60; HG-U133A	SUGP2 GNS SFI1	7.56e-04	197	21	3	1717_DN
Drug	Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	UTY SIPA1L1 SFI1	7.56e-04	197	21	3	2233_DN
Drug	Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A	RBM5 SIPA1L1 SFI1	7.56e-04	197	21	3	2879_UP
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A	SUGP2 KDM6A UTY	7.56e-04	197	21	3	6611_DN
Drug	Aminocaproic acid [60-32-2]; Down 200; 30.4uM; HL60; HT_HG-U133A	RBM5 SIPA1L1 SFI1	7.56e-04	197	21	3	3122_DN
Drug	Ioxaglic acid [59017-64-0]; Down 200; 3.2uM; MCF7; HT_HG-U133A	UTY SFI1 TGS1	7.56e-04	197	21	3	3528_DN
Drug	PNU-0293363 [326823-19-2]; Down 200; 10uM; MCF7; HT_HG-U133A	RBM5 RBM10 SFI1	7.56e-04	197	21	3	6573_DN
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	RBM5 SIPA1L1 SFI1	7.56e-04	197	21	3	2869_UP
Drug	Oxybutynin chloride [1508-65-2]; Down 200; 10.2uM; HL60; HG-U133A	DNAJC7 SUGP2 C1GALT1C1	7.56e-04	197	21	3	1551_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	DNAJC7 MMP15 UTY	7.56e-04	197	21	3	5939_UP
Drug	Butirosin disulfate salt [51022-98-1]; Down 200; 5.4uM; HL60; HT_HG-U133A	SUGP2 GNS SIPA1L1	7.56e-04	197	21	3	2518_DN
Drug	CGX 0596987; Down 200; 20uM; PC3; HT_HG-U133A	MMP15 UTY MMP24	7.56e-04	197	21	3	6369_DN
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MMP15 UTY SFI1	7.68e-04	198	21	3	2771_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Down 200; 12.4uM; MCF7; HT_HG-U133A	SUGP2 GNS TGS1	7.68e-04	198	21	3	5537_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; HL60; HG-U133A	LARS2 PRPF39 RBM10	7.68e-04	198	21	3	1404_DN
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; MCF7; HT_HG-U133A	MMP15 RBM10 SFI1	7.68e-04	198	21	3	6587_DN
Drug	Sulpiride [15676-16-1]; Down 200; 11.8uM; PC3; HG-U133A	DNAJC7 RBM10 SIPA1L1	7.68e-04	198	21	3	1887_DN
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	MMP15 SIPA1L1 TGS1	7.68e-04	198	21	3	6083_DN
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; MCF7; HT_HG-U133A	SUGP2 KDM6A UTY	7.68e-04	198	21	3	5347_UP
Drug	Nitrendipine [39562-70-4]; Down 200; 11uM; PC3; HT_HG-U133A	RBM5 RBM10 TGS1	7.68e-04	198	21	3	6304_DN
Drug	Maprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A	RBM5 GNS SFI1	7.68e-04	198	21	3	3236_DN
Drug	Propantheline bromide [50-34-0]; Down 200; 9uM; HL60; HT_HG-U133A	KDM6A SIPA1L1 SFI1	7.68e-04	198	21	3	3013_DN
Drug	alpha-estradiol; Down 200; 0.01uM; PC3; HG-U133A	LARS2 RBM5 GNS	7.68e-04	198	21	3	702_DN
Drug	5211181; Down 200; 12uM; MCF7; HT_HG-U133A_EA	SUGP2 SIPA1L1 TGS1	7.68e-04	198	21	3	950_DN
Drug	arachidonic acid sodium salt; Up 200; 10uM; MCF7; HG-U133A	RBM5 UTY SFI1	7.68e-04	198	21	3	443_UP
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	1.31e-06	3	20	2	DOID:0060473 (implicated_via_orthology)
Disease	prostate cancer (is_marker_for)	MMP15 KDM6A DNMT1	1.55e-04	156	20	3	DOID:10283 (is_marker_for)
Disease	Medulloblastoma	KDM6A DNMT1	5.24e-04	50	20	2	C0025149
Disease	feeling "fed-up" measurement	LARS2 DCAF5	1.21e-03	76	20	2	EFO_0009588
Disease	otosclerosis	SIPA1L1 DNMT1	1.37e-03	81	20	2	EFO_0004213
Disease	Adenoid Cystic Carcinoma	MIER2 KDM6A	2.08e-03	100	20	2	C0010606
Disease	QRS-T angle	MMP15 SIPA1L1	2.33e-03	106	20	2	EFO_0020097
Disease	congestive heart failure (biomarker_via_orthology)	RBM10 DNMT1	2.37e-03	107	20	2	DOID:6000 (biomarker_via_orthology)
Disease	serum alanine aminotransferase measurement	MMP15 MMP24 DCAF5 DNMT1	2.48e-03	869	20	4	EFO_0004735
Disease	age at first birth measurement	LARS2 SIPA1L1	2.97e-03	120	20	2	EFO_0009101
Disease	colorectal cancer (is_implicated_in)	KDM6A RBM10	3.02e-03	121	20	2	DOID:9256 (is_implicated_in)
Disease	lung non-small cell carcinoma (is_implicated_in)	KDM6A DNMT1	3.96e-03	139	20	2	DOID:3908 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	KDM6A UTY	7.63e-03	195	20	2	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTYFYQLWYDQDYAR	DNMT1	861	P26358
YKYAFDKYRDQYNWF	C1GALT1C1	126	Q96EU7
YYYNAQSQQYLYWDG	RBM10	596	P98175
KEGYYTYFYKGRDYW	MMP24	531	Q9Y5R2
NDAAYTYFYKGTKYW	MMP15	521	P51511
YQRYYSLQSDYWKNA	KDM6A	116	O15550
YKAYKWLRYSYISYS	DCAF5	661	Q96JK2
YYMWKKSERYDYFAQ	MIER3	321	Q7Z3K6
YYYNSLTQQYLYWDG	RBM5	486	P52756
QAVYNYSAWYQYNYQ	PRPF39	641	Q86UA1
YWYALEKNSKYYNYT	GNS	171	P15586
NAYYAKKDYNEAYNY	DNAJC7	36	Q99615
YYLWKKSERYDYFAQ	MIER2	341	Q8N344
YYLYNLMFQTWKTYV	SFI1	151	A8K8P3
SAYQRYYSLQADYWK	UTY	111	O14607
YYKWTQYLFIKLYEA	LARS2	181	Q15031
YYRKFFYQKEHWNYF	SIPA1L1	491	O43166
YWYQGKTYVYYIYGT	SSUH2	341	Q9Y2M2
YWFLSDENSLEYKYY	SUGP2	616	Q8IX01
KWYYYYQSANSSSMN	ZHX1	721	Q9UKY1
YTNSMFDYFLWYKKY	TRAV29DV5	51	P04437
YSQLYWYYLEQFQYW	TGS1	241	Q96RS0