Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rab GDP-dissociation inhibitor activity	GDI1 GDI2	5.90e-06	2	49	2	GO:0005093
GeneOntologyMolecularFunction	procollagen-proline 3-dioxygenase activity	P3H3 P3H2	1.77e-05	3	49	2	GO:0019797
GeneOntologyMolecularFunction	peptidyl-proline 3-dioxygenase activity	P3H3 P3H2	3.53e-05	4	49	2	GO:0031544
GeneOntologyMolecularFunction	procollagen-proline dioxygenase activity	P3H3 P3H2	1.64e-04	8	49	2	GO:0019798
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	2.61e-04	884	49	9	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GPR12 OR9G1 PTPRF GPR25 OR11A1 GALR3 OR1J1 OR5I1 MFSD6 OR13G1 OR9G9	3.53e-04	1353	49	11	GO:0004888
GeneOntologyMolecularFunction	peptidyl-proline dioxygenase activity	P3H3 P3H2	3.83e-04	12	49	2	GO:0031543
GeneOntologyMolecularFunction	olfactory receptor activity	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1 OR9G9	6.23e-04	431	49	6	GO:0004984
GeneOntologyMolecularFunction	GDP-dissociation inhibitor activity	GDI1 GDI2	7.84e-04	17	49	2	GO:0005092
GeneOntologyMolecularFunction	L-ascorbic acid binding	P3H3 P3H2	1.09e-03	20	49	2	GO:0031418
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SHPRH RAD54L2	3.72e-03	37	49	2	GO:0140658
GeneOntologyMolecularFunction	odorant binding	OR9G1 OR5I1 OR13G1	3.74e-03	127	49	3	GO:0005549
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SHPRH RAD54L2 ASCC3	3.74e-03	127	49	3	GO:0008094
Domain	RabGDI	GDI1 GDI2	6.74e-06	2	49	2	IPR000806
Domain	GDP_dissociation_inhibitor	GDI1 GDI2	4.03e-05	4	49	2	IPR018203
Domain	GDI	GDI1 GDI2	4.03e-05	4	49	2	PF00996
Domain	GPCR_Rhodpsn_7TM	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	5.29e-05	670	49	9	IPR017452
Domain	7tm_1	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	5.74e-05	677	49	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	6.28e-05	685	49	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	6.72e-05	691	49	9	PS50262
Domain	GPCR_Rhodpsn	GPR12 OR9G1 GPR25 OR11A1 GALR3 OR1J1 OR5I1 OR13G1 OR9G9	6.79e-05	692	49	9	IPR000276
Domain	2OG-FeII_Oxy_3	P3H3 P3H2	3.65e-04	11	49	2	PF13640
Domain	Olfact_rcpt	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1 OR9G9	5.44e-04	393	49	6	IPR000725
Domain	Pro_4_hyd_alph	P3H3 P3H2	7.90e-04	16	49	2	IPR006620
Domain	P4Hc	P3H3 P3H2	7.90e-04	16	49	2	SM00702
Domain	2OG-FeII_Oxy	P3H3 P3H2	1.12e-03	19	49	2	PF03171
Domain	FE2OG_OXY	P3H3 P3H2	1.37e-03	21	49	2	PS51471
Domain	Oxoglu/Fe-dep_dioxygenase	P3H3 P3H2	1.65e-03	23	49	2	IPR005123
Domain	Helicase_C	SHPRH RAD54L2 ASCC3	2.78e-03	107	49	3	PF00271
Domain	HELICc	SHPRH RAD54L2 ASCC3	2.78e-03	107	49	3	SM00490
Domain	Helicase_C	SHPRH RAD54L2 ASCC3	2.86e-03	108	49	3	IPR001650
Domain	HELICASE_CTER	SHPRH RAD54L2 ASCC3	2.93e-03	109	49	3	PS51194
Domain	HELICASE_ATP_BIND_1	SHPRH RAD54L2 ASCC3	2.93e-03	109	49	3	PS51192
Domain	DEXDc	SHPRH RAD54L2 ASCC3	2.93e-03	109	49	3	SM00487
Domain	Helicase_ATP-bd	SHPRH RAD54L2 ASCC3	3.01e-03	110	49	3	IPR014001
Domain	SNF2_N	SHPRH RAD54L2	3.18e-03	32	49	2	PF00176
Domain	SNF2_N	SHPRH RAD54L2	3.18e-03	32	49	2	IPR000330
Domain	ER_TARGET	P3H3 P3H2	6.76e-03	47	49	2	PS00014
Domain	TPR	TRANK1 P3H3 P3H2	9.26e-03	165	49	3	PS50005
Domain	TPR_REGION	TRANK1 P3H3 P3H2	9.26e-03	165	49	3	PS50293
Domain	-	GDI1 GDI2	9.49e-03	56	49	2	3.50.50.60
Domain	FAD/NAD-binding_dom	GDI1 GDI2	9.82e-03	57	49	2	IPR023753
Pubmed	The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.	P3H3 P3H2	2.03e-06	2	50	2	19436308
Pubmed	Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.	GDI1 GDI2	2.03e-06	2	50	2	7585614
Pubmed	LEPREL1, a novel ER and Golgi resident member of the Leprecan family.	P3H3 P3H2	2.03e-06	2	50	2	15063763
Pubmed	Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.	P3H3 P3H2	6.07e-06	3	50	2	15044469
Pubmed	Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.	GDI1 GDI2	6.07e-06	3	50	2	7513052
Pubmed	Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.	GDI1 GDI2	6.07e-06	3	50	2	7543319
Pubmed	RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.	GDI1 GDI2	6.07e-06	3	50	2	26240314
Pubmed	Expression of prolyl 3-hydroxylase genes in embryonic and adult mouse tissues.	P3H3 P3H2	6.07e-06	3	50	2	19652424
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ACACA PKP4 SEC16A RAD54L2 RBM47	6.16e-06	180	50	5	35198878
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNB ACACA SEC16A ASCC3 DOCK6	1.08e-05	202	50	5	33005030
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	GDI1 GDI2	2.02e-05	5	50	2	11929610
Pubmed	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.	GDI1 GDI2	2.02e-05	5	50	2	19570034
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	GDI1 GDI2	3.03e-05	6	50	2	11809807
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ACACA ELMO2 PKP4 SEC16A PLEKHA6 ADD1	3.08e-05	421	50	6	36976175
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ACACA PKP4 SEC16A PLEKHA6 ASCC3 SIM2 GDI1 GDI2 ADD1	6.33e-05	1247	50	9	27684187
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1	1.28e-04	340	50	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1	1.28e-04	340	50	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1	1.33e-04	343	50	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1	1.39e-04	346	50	5	14611657
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	ELMO2 PKP4 PLEKHA6	1.76e-04	75	50	3	15951569
Pubmed	Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.	P3H3 P3H2	1.82e-04	14	50	2	18798549
Pubmed	Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.	OR13G1 ADD1	2.10e-04	15	50	2	19166692
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ACACA SEC16A ASCC3 ADD1	2.35e-04	209	50	4	36779422
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	MFSD6 PLEKHA6 ADD1	2.54e-04	85	50	3	23055939
Pubmed	MOZ directs the distal-less homeobox gene expression program during craniofacial development.	DLX4 SIM2	2.72e-04	17	50	2	31340933
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNB ACACA SEC16A ASCC3 GDI1 GDI2	3.37e-04	653	50	6	22586326
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	PKP4 PLEKHA6 QKI ADD1	3.44e-04	231	50	4	16452087
Pubmed	Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.	FLNB ACACA	4.59e-04	22	50	2	18487259
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB LZTR1 PTPRF SEC16A ASCC3 CDC25C QKI	4.62e-04	974	50	7	28675297
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	LZTR1 PKP4 SEC16A CDC25C GDI1 GDI2 COG4	5.63e-04	1007	50	7	34597346
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FLNB PKP4 SEC16A ADD1	6.53e-04	274	50	4	34244482
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	SEC16A RAD54L2 DOCK6	7.32e-04	122	50	3	30773093
Pubmed	Endosomal Rab cycles regulate Parkin-mediated mitophagy.	GDI1 GDI2	7.48e-04	28	50	2	29360040
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	SEC16A WDR81 DOCK6 GDI2 COG4	7.76e-04	504	50	5	34432599
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	ACACA SEC16A COG4 ADD1	7.86e-04	288	50	4	23383273
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	FLNB PLEKHA6 ADD1	8.22e-04	127	50	3	30335684
Pubmed	The human olfactory receptor gene family.	OR9G1 OR11A1 OR1J1 OR5I1 OR13G1	1.06e-03	541	50	5	14983052
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNB ACACA SEC16A ASCC3 GDI1 GDI2 ADD1	1.22e-03	1149	50	7	35446349
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	MAGEL2 ASCC3 COG4	1.30e-03	149	50	3	25231870
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	ELMO2 ADD1	1.31e-03	37	50	2	27565344
Cytoband	11q12	NAALADL1 MS4A7	2.41e-04	21	50	2	11q12
Cytoband	3p14.3	FLNB PDE12	4.96e-04	30	50	2	3p14.3
Cytoband	11q11	OR5I1 OR9G9	1.22e-03	47	50	2	11q11
GeneFamily	Olfactory receptors, family 9	OR9G1 OR9G9	8.47e-04	23	34	2	156
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPR12 WDR81 CDC25C	4.70e-03	181	34	3	694
Disease	complement factor H measurement	CPA6 QKI RBM47	4.39e-05	41	49	3	EFO_0008097
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	PAQR9 DOCK6	4.06e-04	18	49	2	OBA_2045155
Disease	pseudotumor cerebri	OR9G1 OR9G9	8.56e-04	26	49	2	EFO_1001132

Protein segments in the cluster

Peptide	Gene	Start	Entry
ITPIYEGRTYYSPVY	PKP4	411	Q99569
ETYYGPGRLYTLIKY	COG4	291	Q9H9E3
YTYPSIYTYATLLPA	GPR12	276	P47775
PYGYVYIPALYLAAF	GPR25	36	O00155
PEDPYKGYRYLYLTP	ACACA	1741	Q13085
LYLNVAPSRYFRPYS	DNHD1	296	Q96M86
SFLYNYEYLGPRLGP	DNHD1	1646	Q96M86
PYTRPSYAQYYPASD	RAD54L2	981	Q9Y4B4
LYPYSYKYATIPNFR	CPA6	331	Q8N4T0
SYSRPYGHLLSYPYT	DLX4	46	Q92988
PESASFDLRYYPYYG	ATP1B4	286	Q9UN42
PYTLAYYGYPYNALI	RBM47	351	A0AV96
YGSILYIYALPRSSY	OR9G1	251	Q8NH87
AGLIYTPYEYPYTLA	QKI	281	Q96PU8
PPAYTYRDYSGLLYL	P3H3	601	Q8IVL6
TLLFIYSRPSYLYSP	OR5I1	256	Q13606
PGSPPRYLLYYYSDS	IGLV5-37	61	A0A075B6J1
YDRYLAICYPLHYPL	OR11A1	121	Q9GZK7
TLYYSPVIYTYIRPA	OR13G1	246	Q8NGZ3
LARYGKSPYLYPLYG	GDI2	216	P50395
PEDSLYLFAAPYYYG	LZTR1	736	Q8N653
YLEYRRIPYTEPAEY	MAGEL2	1166	Q9UJ55
YAFEYYPSTPGRYSI	FLNB	511	O75369
LSSLPYSEYYYPIYE	MS4A7	156	Q9GZW8
VLYPYCAPYALELDY	PDE12	316	Q6L8Q7
YYRTIIGLYFLPPSS	OR1J1	251	Q8NGS3
EPPAYTFRDYSALLY	P3H2	596	Q8IVL5
YGSILYIYALPRSSY	OR9G9	251	P0C7N8
AYGSLYPLLPVYYKQ	MFSD6	81	Q6ZSS7
RSLNQYPALYYPELY	CDC25C	396	P30307
AYYYYLLPGLSLLDA	PAQR9	171	Q6ZVX9
PYLSYYGTVRYGALE	GALR3	156	O60755
YAPHTSYRNLLYVYP	DOCK6	541	Q96HP0
PEYYTLRYADGPQLY	ELMO2	46	Q96JJ3
YVFVPYDALLYSLPY	GUCY2F	276	P51841
YDALLYSLPYKHTPY	GUCY2F	281	P51841
LRPYGYLYRYQPTLP	C1GALT1	326	Q9NS00
LARYGKSPYLYPLYG	GDI1	216	P31150
YRGFYNRPLSPDLSY	PTPRF	1206	P10586
LAAYYTPFPSYGHYR	PRDM14	26	Q9GZV8
LYTPSYSLPFSYHYG	SIM2	431	Q14190
LYYNPYTGCIIREYP	SHPRH	346	Q149N8
IYLYVAPAYGVYLLR	ALG8	201	Q9BVK2
NLGYRTGYPYRYPAL	ADD1	386	P35611
FYTPEIPGRYIYTLY	ASCC3	2146	Q8N3C0
YPVSRRVPEYYGPYS	PLEKHA6	341	Q9Y2H5
VYSLYEPRYRPYDGA	SEC16A	1191	O15027
VFLRYQCYYGYPPLT	SLC66A3	51	Q8N755
PTYVKGYYRAGYSLL	TRANK1	46	O15050
LPSIYPSFTYYRSGE	PSG5	241	Q15238
YGEPVLTYQYLPYIS	WDR81	1306	Q562E7
LTYQYLPYISYLVAP	WDR81	1311	Q562E7
RGSYYEYFGDPLTPY	NAALADL1	246	Q9UQQ1