Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA poly(A) tail shortening	TNRC6A TNRC6B TNKS1BP1 TNRC6C	6.77e-06	33	77	4	GO:0000289
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	TNRC6A TNRC6B TNRC6C	1.77e-05	14	77	3	GO:0060213
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA poly(A) tail shortening	TNRC6A TNRC6B TNRC6C	2.71e-05	16	77	3	GO:0060211
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	TNRC6A TNRC6B NCL TNRC6C NXF1 YTHDF3	4.74e-04	269	77	6	GO:0036464
GeneOntologyCellularComponent	P-body	TNRC6A TNRC6B TNRC6C YTHDF3	5.50e-04	102	77	4	GO:0000932
GeneOntologyCellularComponent	ribonucleoprotein granule	TNRC6A TNRC6B NCL TNRC6C NXF1 YTHDF3	6.66e-04	287	77	6	GO:0035770
GeneOntologyCellularComponent	neuromuscular junction	PCLO PPP1R9A DOCK7 DLG4	7.82e-04	112	77	4	GO:0031594
GeneOntologyCellularComponent	synaptic vesicle	DMXL2 PSEN2 SNAP91 WDR7 DLG4 STX6	8.39e-04	300	77	6	GO:0008021
Domain	Ago_hook	TNRC6A TNRC6B TNRC6C	6.22e-08	3	75	3	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6B TNRC6C	6.22e-08	3	75	3	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6B TNRC6C	6.22e-08	3	75	3	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6B TNRC6C	6.22e-08	3	75	3	PF16608
Domain	FOXO_KIX-bd	FOXO1 FOXO3	1.59e-05	2	75	2	IPR032068
Domain	M_domain	TNRC6A TNRC6C	1.59e-05	2	75	2	PF12938
Domain	GW182_M_dom	TNRC6A TNRC6C	1.59e-05	2	75	2	IPR026805
Domain	FOXO_KIX_bdg	FOXO1 FOXO3	1.59e-05	2	75	2	PF16675
Domain	PDZ	SIPA1L1 PCLO PPP1R9A DLG4 ARHGAP21 TIAM2	3.22e-05	151	75	6	PS50106
Domain	PDZ	SIPA1L1 PCLO PPP1R9A DLG4 ARHGAP21 TIAM2	3.34e-05	152	75	6	IPR001478
Domain	FOXO-TAD	FOXO1 FOXO3	4.76e-05	3	75	2	IPR032067
Domain	FOXO-TAD	FOXO1 FOXO3	4.76e-05	3	75	2	PF16676
Domain	UBA-like	TNRC6A TNRC6B TNRC6C NXF1	1.27e-04	64	75	4	IPR009060
Domain	Ribosomal_S6_kinase_II	RPS6KA1 RPS6KA6	2.36e-04	6	75	2	IPR016239
Domain	PDZ	SIPA1L1 PPP1R9A DLG4 ARHGAP21 TIAM2	2.58e-04	141	75	5	PF00595
Domain	PDZ	SIPA1L1 PPP1R9A DLG4 ARHGAP21 TIAM2	3.23e-04	148	75	5	SM00228
Domain	-	SIPA1L1 PPP1R9A DLG4 ARHGAP21 TIAM2	3.43e-04	150	75	5	2.30.42.10
Domain	RRM	TNRC6A TNRC6B NCL TNRC6C NXF1	2.32e-03	230	75	5	PS50102
Domain	AAA+_ATPase	ABCC3 ATAD5 TAP1 FIGNL1	2.70e-03	144	75	4	IPR003593
Domain	AAA	ABCC3 ATAD5 TAP1 FIGNL1	2.70e-03	144	75	4	SM00382
Domain	-	TNRC6A TNRC6B NCL TNRC6C NXF1	3.00e-03	244	75	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	TNRC6A TNRC6B NCL TNRC6C NXF1	3.80e-03	258	75	5	IPR012677
Domain	ABC_membrane	ABCC3 TAP1	4.15e-03	24	75	2	PF00664
Domain	ABC_TM1F	ABCC3 TAP1	5.62e-03	28	75	2	PS50929
Domain	ABC1_TM_dom	ABCC3 TAP1	5.62e-03	28	75	2	IPR011527
Domain	ZF_PHD_2	PHF2 JADE3 ASXL2	6.61e-03	95	75	3	PS50016
Domain	ZF_PHD_1	PHF2 JADE3 ASXL2	6.80e-03	96	75	3	PS01359
Pathway	REACTOME_SIGNALING_BY_TGFBR3	SP1 PSEN2 TNRC6A TNRC6B TNRC6C	1.79e-06	49	59	5	M48250
Pathway	REACTOME_MAPK6_MAPK4_SIGNALING	FOXO1 FOXO3 TNRC6A TNRC6B TNRC6C CDC42EP3	2.38e-06	93	59	6	M27572
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B TNRC6C	2.41e-06	7	59	3	M46421
Pathway	REACTOME_TGFBR3_EXPRESSION	SP1 TNRC6A TNRC6B TNRC6C	5.26e-06	28	59	4	M48253
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6A TNRC6B TNRC6C	5.75e-06	9	59	3	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6A TNRC6B TNRC6C	5.75e-06	9	59	3	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6A TNRC6B TNRC6C	8.18e-06	10	59	3	M48013
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	SP1 TNRC6A TNRC6B TNRC6C	9.12e-06	32	59	4	M48012
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	SP1 TNRC6A TNRC6B TNRC6C	1.32e-05	35	59	4	M27190
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6A TNRC6B TNRC6C	1.93e-05	13	59	3	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	TNRC6A TNRC6B TNRC6C	4.54e-05	17	59	3	M27788
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	TNRC6A TNRC6B TNRC6C	6.43e-05	19	59	3	M48238
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	SP1 TNRC6A TNRC6B TNRC6C	9.92e-05	58	59	4	M11980
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA1 RPS6KA6	1.71e-04	5	59	2	MM15108
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA1 RPS6KA6 DLG4	2.12e-04	28	59	3	M837
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	2.56e-04	6	59	2	MM15083
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO1 FOXO3	2.56e-04	6	59	2	MM15660
Pathway	KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING	RPS6KA1 RPS6KA6	2.56e-04	6	59	2	M47936
Pathway	WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY	FOXO1 ABCC3 SP1	2.88e-04	31	59	3	M39476
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	TNRC6A TNRC6B TNRC6C	3.17e-04	32	59	3	M27900
Pathway	BIOCARTA_TERT_PATHWAY	SP1 WT1	3.57e-04	7	59	2	MM1541
Pathway	REACTOME_RSK_ACTIVATION	RPS6KA1 RPS6KA6	3.57e-04	7	59	2	M27369
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO1 FOXO3	3.57e-04	7	59	2	MM15661
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	TNRC6A TNRC6B TNRC6C	3.80e-04	34	59	3	M46422
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FOXO1 FOXO3 TNRC6A TNRC6B DLG4 TNRC6C CDC42EP3	4.11e-04	327	59	7	M27565
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA1 RPS6KA6 DLG4	4.14e-04	35	59	3	MM15109
Pathway	BIOCARTA_TERT_PATHWAY	SP1 WT1	4.74e-04	8	59	2	M22015
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	TNRC6A TNRC6B TNRC6C	4.89e-04	37	59	3	M29790
Pathway	WP_INSULIN_SIGNALING	FOXO1 FOXO3 RPS6KA1 RPS6KA6 SH2B2	5.40e-04	160	59	5	MM15956
Pathway	WP_INSULIN_SIGNALING	FOXO1 FOXO3 RPS6KA1 RPS6KA6 SH2B2	5.40e-04	160	59	5	M39482
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	SP1 TNRC6A TNRC6B TNRC6C	5.41e-04	90	59	4	M820
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	SP1 PSEN2 TNRC6A TNRC6B TNRC6C	5.56e-04	161	59	5	M27871
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	TNRC6A TNRC6B TNRC6C	6.63e-04	41	59	3	M29748
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO3	7.58e-04	10	59	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO3	7.58e-04	10	59	2	MM14778
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO1 FOXO3	7.58e-04	10	59	2	M27945
Pathway	WP_NAD_METABOLISM_SIRTUINS_AND_AGING	FOXO1 FOXO3	9.24e-04	11	59	2	M39439
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	TNRC6A TNRC6B TNRC6C	9.91e-04	47	59	3	M29777
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO3	1.11e-03	12	59	2	MM15657
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO3	1.11e-03	12	59	2	M27939
Pathway	REACTOME_CELLULAR_SENESCENCE	SP1 RPS6KA1 TNRC6A TNRC6B TNRC6C	1.38e-03	197	59	5	M27188
Pathway	WP_COPPER_HOMEOSTASIS	FOXO1 FOXO3 SP1	1.41e-03	53	59	3	M39349
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	SP1 TNRC6A TNRC6B TNRC6C	1.44e-03	117	59	4	M19248
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	SIPA1L1 DLG4 GRM1	1.65e-03	56	59	3	M27616
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	RPS6KA1 RPS6KA6	1.75e-03	15	59	2	MM15103
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	FOXO3 RPS6KA1 RPS6KA6 SH2B2	1.89e-03	126	59	4	M16763
Pathway	WP_KIT_RECEPTOR_SIGNALING	FOXO3 RPS6KA1 SH2B2	1.92e-03	59	59	3	M39350
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	FOXO1 FOXO3	1.99e-03	16	59	2	M27940
Pathway	REACTOME_CA2_PATHWAY	TNRC6A TNRC6B TNRC6C	2.21e-03	62	59	3	M27321
Pathway	REACTOME_ESR_MEDIATED_SIGNALING	FOXO3 SP1 TNRC6A TNRC6B TNRC6C	2.23e-03	220	59	5	M27794
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	FOXO1 FOXO3 RPS6KA1 RPS6KA6	2.24e-03	132	59	4	M39338
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO1 FOXO3	2.25e-03	17	59	2	M27946
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2	TNRC6A TNRC6B TNRC6C	2.31e-03	63	59	3	M27862
Pathway	BIOCARTA_PDZS_PATHWAY	PCLO DLG4	2.52e-03	18	59	2	M22001
Pathway	REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT	RPS6KA1 TNRC6A TNRC6B TNRC6C	2.57e-03	137	59	4	M48232
Pathway	PID_TELOMERASE_PATHWAY	SP1 WT1 NCL	2.76e-03	67	59	3	M105
Pathway	WP_IL5_SIGNALING_PATHWAY	FOXO3 RPS6KA1 SH2B2	2.88e-03	68	59	3	MM15930
Pathway	WP_ENDODERM_DIFFERENTIATION	FOXO1 TNRC6C RFX7 ONECUT1	3.00e-03	143	59	4	M39591
Pathway	KEGG_LONG_TERM_POTENTIATION	RPS6KA1 RPS6KA6 GRM1	3.12e-03	70	59	3	M3115
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MEGF8 WDR7 SIPA1L1 PPP1R9A DOCK7 TNRC6B ASXL2 ARRDC3 TNRC6C VIRMA ARHGAP21 ZMYM3	1.42e-10	407	79	12	12693553
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6B TNRC6C	1.13e-08	3	79	3	31670606
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6B TNRC6C	1.13e-08	3	79	3	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6B TNRC6C	1.13e-08	3	79	3	16880270
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6B TNRC6C	4.50e-08	4	79	3	21063388
Pubmed	FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c.	FOXO1 FOXO3 SP1	1.12e-07	5	79	3	22511764
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 SNAP91 WDR7 SIPA1L1 PCLO PPP1R9A DOCK7 DLG4 TNKS1BP1 NCL GRM1 PLEKHG5 VIRMA PRPF40A ARHGAP21 LRCH3	1.16e-07	1431	79	16	37142655
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 SNAP91 WDR7 SIPA1L1 PPP1R9A DOCK7 TNRC6B DLG4 NCL ARMCX4 GRM1 VIRMA ARHGAP21	2.53e-07	963	79	13	28671696
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6B TNRC6C	3.92e-07	7	79	3	19383768
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6B TNRC6C	3.92e-07	7	79	3	19470757
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PHF2 ATXN7L3 SCAF1 GTF2H4 ATAD5 SIPA1L1 PPP1R9A TNRC6A TNRC6B VIRMA NXF1 ZMYM3 STX6 DNAJC2 LRCH3	1.21e-06	1497	79	15	31527615
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 WDR7 SIPA1L1 PCLO PPP1R9A DLG4 GRM1	3.68e-06	281	79	7	28706196
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6A TNRC6B TNRC6C	4.03e-06	14	79	3	19716330
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6A TNRC6B TNRC6C	5.03e-06	15	79	3	21981923
Pubmed	GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.	FOXO1 FOXO3	5.09e-06	2	79	2	24895270
Pubmed	FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway.	FOXO1 FOXO3	5.09e-06	2	79	2	24448243
Pubmed	Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.	FOXO1 FOXO3	5.09e-06	2	79	2	25010393
Pubmed	Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis.	FOXO1 FOXO3	5.09e-06	2	79	2	24269635
Pubmed	Role of GW182 protein in the cell.	TNRC6A TNRC6B	5.09e-06	2	79	2	29791863
Pubmed	Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.	FOXO1 FOXO3	5.09e-06	2	79	2	16952979
Pubmed	Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.	FOXO1 FOXO3	5.09e-06	2	79	2	16709600
Pubmed	Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis.	FOXO1 FOXO3	5.09e-06	2	79	2	31756626
Pubmed	Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.	FOXO1 FOXO3	5.09e-06	2	79	2	15069012
Pubmed	Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling.	FOXO1 FOXO3	5.09e-06	2	79	2	27936162
Pubmed	Lower FOXO3 mRNA expression in granulosa cells is involved in unexplained infertility.	FOXO1 FOXO3	5.09e-06	2	79	2	28621049
Pubmed	Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.	FOXO1 FOXO3	5.09e-06	2	79	2	28430387
Pubmed	m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance.	VIRMA YTHDF3	5.09e-06	2	79	2	30866959
Pubmed	[Analysis of FOXO1A and FOXO3A Gene Allele Association with Human Longevity].	FOXO1 FOXO3	5.09e-06	2	79	2	27529982
Pubmed	Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells.	FOXO1 FOXO3	5.09e-06	2	79	2	25952685
Pubmed	The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis.	FOXO1 FOXO3	5.09e-06	2	79	2	32332845
Pubmed	Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth.	FOXO1 FOXO3	5.09e-06	2	79	2	30511639
Pubmed	FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.	FOXO1 FOXO3	5.09e-06	2	79	2	20142102
Pubmed	Foxo transcription factors control regulatory T cell development and function.	FOXO1 FOXO3	5.09e-06	2	79	2	21167754
Pubmed	Transcription factor SP1 mediates hyperglycemia-induced upregulation of roundabout4 in retinal microvascular endothelial cells.	ROBO4 SP1	5.09e-06	2	79	2	28341181
Pubmed	Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.	FOXO1 FOXO3	5.09e-06	2	79	2	19793722
Pubmed	P. gingivalis modulates keratinocytes through FOXO transcription factors.	FOXO1 FOXO3	5.09e-06	2	79	2	24265696
Pubmed	Forkhead box class O transcription factors in liver function and disease.	FOXO1 FOXO3	5.09e-06	2	79	2	23855308
Pubmed	Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.	FOXO1 FOXO3	5.09e-06	2	79	2	21565617
Pubmed	Association study to evaluate Foxo1 and Foxo3 gene polymorphisms in polycystic ovary syndrome: a preliminary case-control study and in silico analysis.	FOXO1 FOXO3	5.09e-06	2	79	2	36790598
Pubmed	FoxO transcription factors support oxidative stress resistance in human chondrocytes.	FOXO1 FOXO3	5.09e-06	2	79	2	25186470
Pubmed	FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.	FOXO1 FOXO3	5.09e-06	2	79	2	21159781
Pubmed	Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.	SP1 TIAM2	5.09e-06	2	79	2	26763486
Pubmed	FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.	FOXO1 FOXO3	5.09e-06	2	79	2	17254970
Pubmed	A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation.	FOXO1 FOXO3	5.09e-06	2	79	2	22552808
Pubmed	Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure.	FOXO1 FOXO3	5.09e-06	2	79	2	16979636
Pubmed	FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development.	FOXO1 FOXO3	5.09e-06	2	79	2	35757763
Pubmed	Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.	FOXO1 FOXO3	5.09e-06	2	79	2	16100571
Pubmed	Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP.	SIPA1L1 DLG4	5.09e-06	2	79	2	11502259
Pubmed	Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells.	FOXO1 FOXO3	5.09e-06	2	79	2	22515357
Pubmed	VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.	E2F7 VIRMA	5.09e-06	2	79	2	37028765
Pubmed	Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.	FOXO1 FOXO3	5.09e-06	2	79	2	22932683
Pubmed	SP1 upregulated FoxO3a promotes tumor progression in colorectal cancer.	FOXO3 SP1	5.09e-06	2	79	2	29565456
Pubmed	Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese.	FOXO1 FOXO3	5.09e-06	2	79	2	24489705
Pubmed	FOXOs in the impaired heart: New therapeutic targets for cardiac diseases.	FOXO1 FOXO3	5.09e-06	2	79	2	27890702
Pubmed	Effects of FOXO genotypes on longevity: a biodemographic analysis.	FOXO1 FOXO3	5.09e-06	2	79	2	20884733
Pubmed	FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway.	FOXO1 FOXO3	5.09e-06	2	79	2	22931788
Pubmed	Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.	FOXO1 FOXO3	5.09e-06	2	79	2	18823877
Pubmed	Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology.	FOXO1 FOXO3	5.09e-06	2	79	2	19747349
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXO1 FOXO3 SP1 DACH2 WT1 E2F7 RFX7 PRDM7 ONECUT1 TCFL5 DNAJC2	6.48e-06	908	79	11	19274049
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PHF2 ATXN7L3 SCAF1 IL12RB2 ATAD5 SIPA1L1 TNRC6A TNRC6B DLG4 KPNA6 PRPF40A ZMYM3	7.94e-06	1116	79	12	31753913
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	SIPA1L1 TNRC6A DOCK7 TNRC6B TNKS1BP1 ARHGAP21	8.46e-06	209	79	6	36779422
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF1 SP1 JADE3 SIPA1L1 TNKS1BP1 NCL RFX7 VIRMA PRPF40A ZMYM3	1.02e-05	774	79	10	15302935
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	SIPA1L1 PCLO TNRC6A TNRC6B DLG4 TNRC6C	1.07e-05	218	79	6	33378226
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHF2 DMXL2 SIPA1L1 TNRC6B TNKS1BP1 TNRC6C	1.29e-05	225	79	6	12168954
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DMXL2 SNAP91 WDR7 SIPA1L1 PCLO DLG4 TNKS1BP1	1.45e-05	347	79	7	17114649
Pubmed	A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.	FOXO1 FOXO3	1.53e-05	3	79	2	25576059
Pubmed	Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.	DOCK7 GPNMB	1.53e-05	3	79	2	28899684
Pubmed	Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.	SP1 NCL	1.53e-05	3	79	2	32851058
Pubmed	Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet.	FOXO1 FOXO3	1.53e-05	3	79	2	27235148
Pubmed	STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.	FOXO1 FOXO3	1.53e-05	3	79	2	21730069
Pubmed	FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.	FOXO1 FOXO3	1.53e-05	3	79	2	12857750
Pubmed	Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells.	FOXO1 FOXO3	1.53e-05	3	79	2	16133873
Pubmed	FoxO transcription factors 1 regulate mouse preimplantation embryo development.	FOXO1 FOXO3	1.53e-05	3	79	2	31396850
Pubmed	FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development.	FOXO1 FOXO3	1.53e-05	3	79	2	25929834
Pubmed	Functional regulation of FoxO1 in neural stem cell differentiation.	FOXO1 FOXO3	1.53e-05	3	79	2	26470727
Pubmed	Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes.	FOXO1 FOXO3	1.53e-05	3	79	2	27491024
Pubmed	Loss of E2F7 expression is an early event in squamous differentiation and causes derepression of the key differentiation activator Sp1.	SP1 E2F7	1.53e-05	3	79	2	21248772
Pubmed	FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump.	FOXO1 FOXO3	1.53e-05	3	79	2	18272820
Pubmed	Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity.	FOXO1 FOXO3	1.53e-05	3	79	2	31767172
Pubmed	Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.	FOXO1 FOXO3	1.53e-05	3	79	2	22102632
Pubmed	Forkhead BoxO transcription factors restrain exercise-induced angiogenesis.	FOXO1 FOXO3	1.53e-05	3	79	2	25063823
Pubmed	FOXOs attenuate bone formation by suppressing Wnt signaling.	FOXO1 FOXO3	1.53e-05	3	79	2	23867625
Pubmed	The FoxO transcription factors and metabolic regulation.	FOXO1 FOXO3	1.53e-05	3	79	2	18022395
Pubmed	Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.	FOXO1 FOXO3	1.53e-05	3	79	2	26232637
Pubmed	Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.	FOXO1 FOXO3	1.53e-05	3	79	2	26917725
Pubmed	Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.	FOXO1 FOXO3	1.53e-05	3	79	2	24123662
Pubmed	SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.	FOXO1 FOXO3	1.53e-05	3	79	2	24003218
Pubmed	FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.	FOXO1 FOXO3	1.53e-05	3	79	2	20142101
Pubmed	Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.	FOXO1 FOXO3	1.53e-05	3	79	2	24015318
Pubmed	FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.	FOXO1 FOXO3	1.53e-05	3	79	2	33634126
Pubmed	STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.	FOXO1 FOXO3	1.53e-05	3	79	2	22761423
Pubmed	The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer.	FOXO1 FOXO3	1.53e-05	3	79	2	22159921
Pubmed	Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective.	FOXO1 FOXO3	1.53e-05	3	79	2	32847377
Pubmed	FoxO family members in cancer.	FOXO1 FOXO3	1.53e-05	3	79	2	21613825
Pubmed	FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage.	FOXO1 FOXO3	1.53e-05	3	79	2	19671690
Pubmed	FoxO regulates expression of ABCA6, an intracellular ATP-binding-cassette transporter responsive to cholesterol.	FOXO1 FOXO3	1.53e-05	3	79	2	24028821
Pubmed	Lipid availability determines fate of skeletal progenitor cells via SOX9.	FOXO1 FOXO3	1.53e-05	3	79	2	32103177
Pubmed	Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells.	FOXO1 FOXO3	1.53e-05	3	79	2	26929388
Pubmed	FOXO transcription factors protect against the diet-induced fatty liver disease.	FOXO1 FOXO3	1.53e-05	3	79	2	28300161
Pubmed	Inhibition of FOXO1/3 promotes vascular calcification.	FOXO1 FOXO3	1.53e-05	3	79	2	25378413
Interaction	FOXO3B interactions	FOXO1 FOXO3 VIRMA	1.11e-06	6	78	3	int:FOXO3B
Interaction	CNOT6L interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C VIRMA YTHDF3	1.61e-06	93	78	6	int:CNOT6L
Interaction	ODF2 interactions	FOXO1 SP1 SIPA1L1 TNRC6A TNRC6B TNRC6C ARHGAP21	2.64e-06	158	78	7	int:ODF2
Interaction	MYO6 interactions	SP1 SIPA1L1 PPP1R9A DOCK7 PLEKHG5 VIRMA NXF1 STX6 DNAJC2 LRCH3	3.07e-06	398	78	10	int:MYO6
Interaction	CAPZA2 interactions	TGM3 PPP1R9A DOCK7 DLG4 TNKS1BP1 ASXL2 GPNMB VIRMA ARHGAP21 LRCH3	6.07e-06	430	78	10	int:CAPZA2
Interaction	AGO1 interactions	TNRC6A TNRC6B NCL TNRC6C VIRMA NXF1 YTHDF3	6.96e-06	183	78	7	int:AGO1
Interaction	MIF interactions	SIPA1L1 TNRC6A DOCK7 TNRC6B TNRC6C VIRMA FIGNL1 LRCH3	8.28e-06	264	78	8	int:MIF
Interaction	TNIK interactions	SNAP91 SIPA1L1 DOCK7 DLG4 ARRDC3 VIRMA ARHGAP21 TIAM2 DNAJC2	1.62e-05	381	78	9	int:TNIK
Interaction	CNOT7 interactions	FOXO3 TNRC6A TNRC6B TNKS1BP1 TNRC6C YTHDF3	1.72e-05	140	78	6	int:CNOT7
Interaction	VASP interactions	SIPA1L1 TNRC6A TNRC6B TNKS1BP1 VIRMA PRPF40A ARHGAP21 NXF1	1.81e-05	294	78	8	int:VASP
Interaction	ABR interactions	DLG4 ARRDC3 VIRMA NXF1	1.89e-05	41	78	4	int:ABR
Interaction	GPBP1L1 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C NXF1	2.08e-05	86	78	5	int:GPBP1L1
Interaction	ANKRD52 interactions	SNAP91 TNRC6B NXF1 DNAJC2 LRCH3	2.20e-05	87	78	5	int:ANKRD52
Interaction	GARRE1 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C VIRMA YTHDF3	4.64e-05	167	78	6	int:GARRE1
Interaction	CEP85 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C NXF1 YTHDF3	4.96e-05	169	78	6	int:CEP85
Interaction	TAMALIN interactions	RPS6KA1 DLG4 GRM1	5.17e-05	19	78	3	int:TAMALIN
Interaction	DYRK1A interactions	FOXO1 SIPA1L1 DOCK7 TNKS1BP1 KPNA6 ARRDC3 RFX7 VIRMA NXF1 LRCH3	5.18e-05	552	78	10	int:DYRK1A
Interaction	ARHGEF2 interactions	FOXO3 PPP1R9A DOCK7 ARRDC3 VIRMA ARHGAP21 NXF1	6.03e-05	256	78	7	int:ARHGEF2
Interaction	CNOT6 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C	6.55e-05	56	78	4	int:CNOT6
Interaction	KCTD13 interactions	DMXL2 SNAP91 WDR7 SIPA1L1 PCLO PPP1R9A DOCK7 DLG4 TNKS1BP1 NCL GRM1 PLEKHG5 VIRMA PRPF40A ARHGAP21 LRCH3	7.24e-05	1394	78	16	int:KCTD13
Interaction	ZFP36 interactions	TNRC6A TNRC6B TNKS1BP1 NCL TNRC6C YTHDF3	7.26e-05	181	78	6	int:ZFP36
Interaction	CNOT11 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C YTHDF3	7.41e-05	112	78	5	int:CNOT11
Interaction	SYNM interactions	FOXO1 TNRC6A TNRC6C VIRMA	7.52e-05	58	78	4	int:SYNM
Interaction	YWHAG interactions	FOXO1 FOXO3 RPS6KA1 SIPA1L1 DOCK7 DLG4 RFX7 PLEKHG5 PGD VIRMA PRPF40A ARHGAP21 PDCD4 ZMYM3 LRCH3	7.56e-05	1248	78	15	int:YWHAG
Interaction	FIRRE interactions	VIRMA NXF1	8.83e-05	4	78	2	int:FIRRE
Interaction	MIF4GD-DT interactions	VIRMA NXF1	8.83e-05	4	78	2	int:MIF4GD-DT
Interaction	ZCCHC2 interactions	ARRDC3 VIRMA YTHDF3	9.34e-05	23	78	3	int:ZCCHC2
Interaction	DMXL1 interactions	DMXL2 WDR7 VIRMA STX6	9.77e-05	62	78	4	int:DMXL1
Interaction	CEP192 interactions	TNRC6A TNRC6B TNRC6C VIRMA NXF1 DNAJC2	1.01e-04	192	78	6	int:CEP192
Interaction	TNRC6B interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C VIRMA NXF1 YTHDF3	1.10e-04	282	78	7	int:TNRC6B
Interaction	WASHC2A interactions	FOXO1 DOCK7 VIRMA STX6 DNAJC2	1.11e-04	122	78	5	int:WASHC2A
Interaction	SAMD4B interactions	FOXO1 SIPA1L1 TNRC6B VIRMA YTHDF3	1.11e-04	122	78	5	int:SAMD4B
Interaction	CNOT4 interactions	TNRC6A TNRC6B TNKS1BP1 YTHDF3	1.18e-04	65	78	4	int:CNOT4
Interaction	PAN3 interactions	TNRC6A TNRC6B TNRC6C YTHDF3	1.18e-04	65	78	4	int:PAN3
Interaction	ANK3 interactions	DOCK7 DLG4 TNKS1BP1 ARHGAP21 STX6 LRCH3	1.29e-04	201	78	6	int:ANK3
Interaction	FHL2 interactions	FOXO1 SP1 PSEN2 WT1 E2F7 TNKS1BP1 ASXL2 REV1	1.46e-04	396	78	8	int:FHL2
Interaction	PSG5 interactions	TIE1 PRPF40A	1.47e-04	5	78	2	int:PSG5
Interaction	KIZ interactions	TNRC6A TNRC6B TNRC6C	1.53e-04	27	78	3	int:KIZ
Interaction	UBAP2L interactions	FOXO1 TNRC6A TNRC6B TNRC6C VIRMA NXF1 YTHDF3	1.55e-04	298	78	7	int:UBAP2L
Interaction	FAM193A interactions	TNRC6A TNRC6B VIRMA YTHDF3	1.66e-04	71	78	4	int:FAM193A
Interaction	UNK interactions	TNRC6A TNRC6B TNKS1BP1 KPNA6 NCL TNRC6C PDCD4 YTHDF3	1.79e-04	408	78	8	int:UNK
Interaction	BTRC interactions	FOXO3 SP1 TGM3 TNRC6A TNRC6B TNKS1BP1 NCL PLEKHG5 PDCD4 NXF1 YTHDF3	1.88e-04	775	78	11	int:BTRC
Interaction	CNOT8 interactions	TNRC6A TNRC6B TNRC6C YTHDF3	1.95e-04	74	78	4	int:CNOT8
Interaction	TNRC6C interactions	TNRC6A TNRC6B TNRC6C VIRMA YTHDF3	1.98e-04	138	78	5	int:TNRC6C
Interaction	GPBP1 interactions	TNRC6A TNRC6B TNRC6C NXF1	2.05e-04	75	78	4	int:GPBP1
Interaction	CNOT10 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C YTHDF3	2.19e-04	141	78	5	int:CNOT10
Interaction	EVC interactions	VIRMA NXF1	2.20e-04	6	78	2	int:EVC
Interaction	CPEB3 interactions	VIRMA NXF1	2.20e-04	6	78	2	int:CPEB3
Interaction	MEX3B interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C VIRMA YTHDF3	2.22e-04	222	78	6	int:MEX3B
Interaction	ANKRD17 interactions	TNRC6A TNRC6B TNKS1BP1 TNRC6C VIRMA YTHDF3	2.44e-04	226	78	6	int:ANKRD17
Interaction	RPS6KA1 interactions	RPS6KA1 PPP1R9A DLG4 PGD TAP1 PDCD4	2.56e-04	228	78	6	int:RPS6KA1
Interaction	ITSN2 interactions	TNRC6A TNRC6B GPNMB TNRC6C VIRMA	2.65e-04	147	78	5	int:ITSN2
Interaction	HTT interactions	PHF2 SP1 SNAP91 RPS6KA1 SIPA1L1 PCLO DLG4 NCL GRM1 VIRMA PRPF40A STX6	2.73e-04	949	78	12	int:HTT
Interaction	BRCA1 interactions	FOXO3 SP1 GTF2H4 SNAP91 TNRC6A TNRC6B KPNA6 NCL TNRC6C PGD ARHGAP21 ZMYM3 YTHDF3 REV1	2.80e-04	1249	78	14	int:BRCA1
Interaction	ZYX interactions	FOXO1 SIPA1L1 TNRC6A TNRC6B TNKS1BP1 ARHGAP21 YTHDF3	2.84e-04	329	78	7	int:ZYX
Interaction	KRT8 interactions	SIPA1L1 TNRC6A DOCK7 TNRC6B TNRC6C VIRMA ARHGAP21 YTHDF3	3.03e-04	441	78	8	int:KRT8
Interaction	EEF1D interactions	FOXO1 RPS6KA1 TNRC6B TNKS1BP1 ASXL2 VIRMA ARHGAP21	3.05e-04	333	78	7	int:EEF1D
Interaction	SMG5 interactions	TNRC6A TNRC6B NXF1 YTHDF3	3.17e-04	84	78	4	int:SMG5
Interaction	AGO3 interactions	TNRC6A TNRC6B TNRC6C VIRMA YTHDF3	3.19e-04	153	78	5	int:AGO3
Interaction	YWHAQ interactions	FOXO1 FOXO3 RPS6KA1 SIPA1L1 DOCK7 NCL ARRDC3 RFX7 PLEKHG5 PGD VIRMA ARHGAP21 PDCD4	3.35e-04	1118	78	13	int:YWHAQ
Interaction	LRP8 interactions	PPP1R9A DLG4 VIRMA NXF1	3.47e-04	86	78	4	int:LRP8
Interaction	CPEB4 interactions	TNRC6A TNRC6B TNRC6C VIRMA YTHDF3	3.49e-04	156	78	5	int:CPEB4
Interaction	SPATA2 interactions	TNRC6A TNRC6B TNRC6C VIRMA	3.62e-04	87	78	4	int:SPATA2
Interaction	CALM3 interactions	ABHD10 PPP1R9A DOCK7 ARHGAP21 PDCD4 NXF1 LRCH3	3.65e-04	343	78	7	int:CALM3
Interaction	YTHDF3 interactions	FOXO1 TNRC6A TNRC6B TNRC6C VIRMA YTHDF3	3.84e-04	246	78	6	int:YTHDF3
Interaction	ATP10D interactions	VIRMA NXF1	4.08e-04	8	78	2	int:ATP10D
Interaction	IFI16 interactions	SP1 PPP1R9A DOCK7 E2F7 TNKS1BP1 NCL VIRMA PRPF40A NXF1 LRCH3	4.19e-04	714	78	10	int:IFI16
Interaction	GSK3A interactions	SIPA1L1 TNRC6A DOCK7 TNRC6B TNKS1BP1 RFX7 PRPF40A ARHGAP21	4.25e-04	464	78	8	int:GSK3A
Interaction	WDR7 interactions	DMXL2 WDR7 VIRMA STX6	4.67e-04	93	78	4	int:WDR7
Interaction	HELZ interactions	TNRC6A TNRC6B TNRC6C VIRMA NXF1 YTHDF3	4.84e-04	257	78	6	int:HELZ
Interaction	MPHOSPH9 interactions	TNRC6A TNRC6B TNRC6C VIRMA	5.06e-04	95	78	4	int:MPHOSPH9
Interaction	ANKRD33B interactions	VIRMA NXF1	5.23e-04	9	78	2	int:ANKRD33B
Interaction	KALRN interactions	SIPA1L1 PPP1R9A DLG4 VIRMA	5.27e-04	96	78	4	int:KALRN
Interaction	TSC1 interactions	FOXO3 DACH2 RPS6KA1 DOCK7 DLG4 NXF1 STX6	5.38e-04	366	78	7	int:TSC1
Cytoband	7q22	MUC3B SH2B2 DNAJC2	3.96e-05	38	79	3	7q22
Cytoband	1p35.1	BSDC1 KPNA6	1.40e-03	32	79	2	1p35.1
Cytoband	15q21.3	RFX7 ONECUT1	1.68e-03	35	79	2	15q21.3
GeneFamily	PDZ domain containing	SIPA1L1 PCLO PPP1R9A DLG4 ARHGAP21 TIAM2	8.15e-06	152	57	6	1220
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6A TNRC6B TNRC6C	6.50e-05	25	57	3	775
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA1 RPS6KA6	5.27e-04	11	57	2	1156
Coexpression	IKEDA_MIR1_TARGETS_UP	NCL ARRDC3 ARHGAP21 PDCD4	2.05e-05	54	78	4	MM927
Coexpression	IKEDA_MIR1_TARGETS_UP	NCL ARRDC3 ARHGAP21 PDCD4	2.05e-05	54	78	4	M2372
Coexpression	GSE22601_IMMATURE_CD4_SINGLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP	IL12RB2 DACH2 RPS6KA1 SIPA1L1 CDC42EP3 NXF1	2.98e-05	200	78	6	M6248
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_DN	DACH2 GPNMB ARMCX4	3.75e-05	22	78	3	M2039
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_DN	DACH2 GPNMB ARMCX4	4.30e-05	23	78	3	MM484
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; HL60; HT_HG-U133A	SEMG2 ROBO4 ABCC3 SIPA1L1 PCLO DLG4 ONECUT1	5.97e-06	199	79	7	3013_UP
Drug	glycylsarcosine	TGM3 DSPP DLG4 TAP1	6.48e-06	35	79	4	CID000093131
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA1 RPS6KA6	3.81e-05	4	75	2	DOID:3783 (implicated_via_orthology)
Disease	Uterine leiomyoma	FOXO1 WT1 TNRC6B REV1	8.70e-05	91	75	4	HP_0000131
Disease	electrodermal activity measurement, skin conductance response amplitude	COL4A6 PSEN2	1.33e-04	7	75	2	EFO_0006866, EFO_0006868
Disease	white matter microstructure measurement	SCAF1 TIE1 ASXL2 PRDM7 ARHGAP21 STX6	4.79e-04	390	75	6	EFO_0005674
Disease	cortical thickness	FOXO3 SP1 SNAP91 NUP210L TNRC6A DOCK7 TNRC6B CDC42EP3 ARHGAP21 STX6	5.02e-04	1113	75	10	EFO_0004840
Disease	neuroticism measurement, cognitive function measurement	FOXO3 SCAF1 PSEN2 NUP210L SIPA1L1 PCLO TNRC6A	5.92e-04	566	75	7	EFO_0007660, EFO_0008354
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DLG4 RFX7	8.46e-04	17	75	2	DOID:0060307 (is_implicated_in)
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	ATAD5 TNRC6B	9.50e-04	18	75	2	EFO_1000649, HP_0000131
Disease	hematocrit	FOXO1 ATXN7L3 TIE1 WT1 TNRC6B DLG4 ASXL2 PGD ARHGAP21	1.04e-03	1011	75	9	EFO_0004348
Disease	waist-hip ratio	FOXO3 DMXL2 MEGF8 TNRC6A WT1 TNRC6B RFX7 ONECUT1 CDC42EP3 ARHGAP21	1.05e-03	1226	75	10	EFO_0004343
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PCLO CDC42EP3	1.06e-03	19	75	2	EFO_0007044, EFO_0020106
Disease	body weight	FOXO1 FOXO3 DACH2 ATAD5 DSPP TNRC6A BSDC1 E2F7 TNRC6B VIRMA	1.30e-03	1261	75	10	EFO_0004338
Disease	thalamus volume	FOXO3 RFX7 STX6	1.34e-03	85	75	3	EFO_0006935
Disease	body composition measurement	ATAD5 WT1 TNRC6B ARHGAP21	1.50e-03	193	75	4	EFO_0005106
Disease	uterine fibroid	FOXO1 WT1 TNRC6B REV1	1.68e-03	199	75	4	EFO_0000731
Disease	Neurodevelopmental Disorders	PHF2 TNRC6B DLG4	1.74e-03	93	75	3	C1535926
Disease	social interaction measurement	PHF2 SIPA1L1 TNRC6B	1.79e-03	94	75	3	EFO_0009592
Disease	glycerol measurement	TGM3 PCLO	1.99e-03	26	75	2	EFO_0010115
Disease	ganglion cell inner plexiform layer thickness measurement	FOXO3 SNAP91	2.31e-03	28	75	2	EFO_0600005

Protein segments in the cluster

Peptide	Gene	Start	Entry
SNDGWTSQSSGELKA	ATAD5	1696	Q96QE3
WLKGDKGSQGSAGSN	COL4A6	966	Q14031
NNGKKGSSTDISEDW	BSDC1	381	Q9NW68
TAWSEDSDGENGTGQ	GPNMB	136	Q14956
DSAGQKGTGKWTAIS	PGD	256	P52209
NGSKWAEVGGKSFST	DSPP	81	Q9NZW4
SGTTTKKGDLQWNAG	SNAP91	771	O60641
LSDGNGSSGIEWSNV	DMXL2	1941	Q8TDJ6
SWGSSGSASQSSQGR	CDC42EP3	171	Q9UKI2
DDLNSNTGGSESSWD	DACH2	251	Q96NX9
EKSTGGGGNGSKNWS	DNAJC2	441	Q99543
QTSEGTWAGDKASGG	ARMCX4	1196	Q5H9R4
KASGGAWTGAENQAS	ARMCX4	1206	Q5H9R4
QSSGGAWAGTLDQSG	ARMCX4	1371	Q5H9R4
SSGRSWANSGDQISG	ARMCX4	1421	Q5H9R4
RGESLSSGKTETWNG	ARRDC3	251	Q96B67
GSSKTSENQGWGLGT	ATXN7L3	286	Q14CW9
SENQGWGLGTNSSES	ATXN7L3	291	Q14CW9
ATWEGKQSDGQTGSP	ASXL2	211	Q76L83
GSGDSSGDSWTKQVT	MKRN4P	81	Q13434
SWNEGTLSGQSSESG	RFTN2	196	Q52LD8
GSGELGSKFWDSNLS	ABCC3	6	O15438
MTGQGQSASGSSAWS	SLC25A32	1	Q9H2D1
GSQQTDSDKWQSGLS	FIGNL1	91	Q6PIW4
KEAAWAITNATSGGT	KPNA6	396	O60684
SGFNSVDSGDKRWSG	LRCH3	311	Q96II8
GNWAVAVSAANSKGS	IL12RB2	391	Q99665
NGWTDSTVSQGITDG	PCLO	2881	Q9Y6V0
KDSVWGSGGGQQSVN	PDCD4	311	Q53EL6
GGAGTSQDGTSKNWF	NXF1	106	Q9UBU9
LDKWQDEGSSNSGNS	ONECUT1	441	Q9UBC0
NGSSSWGFNASVGSA	MEGF8	1391	Q7Z7M0
KFSLSGGNWDNISDG	RPS6KA6	641	Q9UK32
TGWGLVSKQGETSDE	PRSS38	186	A1L453
QDYRGGKNSTWSGES	NCL	471	P19338
DSGNWDTSGSELSEG	PRPF40A	926	O75400
QEGAGDSPGSQFSKW	FOXO1	281	Q12778
SGKATANSLVSSEWG	E2F7	666	Q96AV8
SKGLDRSNSWVNTGG	DOCK7	921	Q96N67
SLDWSTGKTGRAGDQ	DPH7	146	Q9BTV6
RLKAKDWGSSSGSQG	DLG4	501	P78352
AGAGNANSNGKSVSW	GRM1	881	Q13255
ANSNGKSVSWSEPGG	GRM1	886	Q13255
SKFAKSNGLEGSWSG	JADE3	661	Q92613
SNGLEGSWSGNVTQK	JADE3	666	Q92613
GSWSGNVTQKDSSSE	JADE3	671	Q92613
GGSGNFTWTSSNETV	NUP210L	491	Q5VU65
TTTAGTCDNGGTWEQ	MUC3B	866	Q9H195
DKGDSNSSAGWKNSI	FOXO3	196	O43524
SRNGSLKTWNGGESL	TRMT44	631	Q8IYL2
SAVQKEGSGGNAWDS	TNRC6C	286	Q9HCJ0
SNSDINGKGSTGWES	TNRC6C	351	Q9HCJ0
SGSGWNDTTRSGNSG	TNRC6C	626	Q9HCJ0
SGNSGWGNSTNTKAN	TNRC6C	636	Q9HCJ0
VSNWGGAASVKQTGT	TNRC6C	676	Q9HCJ0
LQTTWGAGQAKGSSL	PHF2	811	O75151
ASSGAASGRKSSWQG	PRDM7	396	Q9NQW5
QSDIGGSGKSTPSWQ	SIPA1L1	1191	O43166
QALLGDSGSQNWSTG	STX6	121	O43752
GSKSENAGAQGWLAA	TAP1	81	Q03518
DQWSGQNAKGKSGQS	SEMG2	516	Q02383
SQGANGWQIISSSSG	SP1	101	P08047
GSLANGWGSASEDNA	ROBO4	871	Q8WZ75
SGGWSAVLQASNGNT	TGM3	81	Q08188
GSSDGNSEESTLGKW	ABHD10	116	Q9NUJ1
WGLTSSGAGQDSSAQ	LINC01561	51	Q8N1V8
ALLGGGKAWSDDTSQ	GTF2H4	121	Q92759
GSSGSTNTGDSWKNR	PLEKHG5	231	O94827
ADFSTWGTSGSQGQS	YTHDF3	131	Q7Z739
QGSSQASAFLWSGGS	TIAM2	421	Q8IVF5
SSSNEWTGETGKGTL	TIAM2	1501	Q8IVF5
SPDTNKAESSGKWNG	REV1	901	Q9UBZ9
SQAAGTKGAEETSWS	SCAF1	951	Q9H7N4
GDWSNTVEESTLGNG	TIE1	726	P35590
EKSSGSEGSSPNWLQ	TNKS1BP1	1706	Q9C0C2
AKGWSQGVGEVTSTS	FAM170A	41	A1A519
AAGSSSSVKWTEGQS	WT1	251	P19544
KAAATGSGDWNTTLA	PSEN2	376	P49810
DDAAAGSGGSAQWQK	SH2B2	206	O14492
DSDSKSVGSFNPNGW	RFX7	671	Q2KHR2
ATSDSTKSKGSWGSG	ARHGAP21	1386	Q5T5U3
GEGATATQGAWQSSE	TCFL5	366	Q9UL49
WCRGSSKSNVGTSGD	POTEG	71	Q6S5H5
SWASANSGSGGSRGK	VIRMA	1781	Q69YN4
NGQTWTGGDFVSSDK	WDR7	256	Q9Y4E6
GAQGTASWGSGTKDL	ZMYND15	226	Q9H091
GGVWESGAANSQSTS	TNRC6A	571	Q8NDV7
NGNGKTFTNGWKSTE	TNRC6A	631	Q8NDV7
DGQKSSQGWSVSASD	TNRC6A	841	Q8NDV7
WGEANKKSSSGGSDS	TNRC6A	866	Q8NDV7
ASAISNKEASSGSGW	TNRC6A	1046	Q8NDV7
WNTKDSVVAQTGSGG	ZMYM3	361	Q14202
SQSTGDRKTGSVGSW	TNRC6B	411	Q9UPQ9
EGWESAATQTKNSGG	TNRC6B	651	Q9UPQ9
AATQTKNSGGWGDAP	TNRC6B	656	Q9UPQ9
SSHNSASWGQGGKKQ	TNRC6B	1031	Q9UPQ9
SGKFTLSGGNWNTVS	RPS6KA1	631	Q15418
LSGGNWNTVSETAKD	RPS6KA1	636	Q15418
PQDEWGGSKSNRGST	PPP1R9A	171	Q9ULJ8