Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNA1E CACNA1S	1.22e-05	14	66	3	GO:0008331
GeneOntologyMolecularFunction	gated channel activity	CACNA1B GABRG3 CACNA1E CACNA1S ABCC8 PIEZO1 KCNN2 RYR3	1.39e-05	334	66	8	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1B CACNA1E CACNA1S ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	1.69e-05	343	66	8	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1B GABRG3 CACNA1E CACNA1S ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	1.92e-05	459	66	9	GO:0005216
GeneOntologyMolecularFunction	channel activity	CACNA1B GABRG3 CACNA1E CACNA1S ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	5.47e-05	525	66	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1B GABRG3 CACNA1E CACNA1S ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	5.56e-05	526	66	9	GO:0022803
GeneOntologyMolecularFunction	calcium channel activity	CACNA1B CACNA1E CACNA1S ORAI2 RYR3	6.79e-05	129	66	5	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1B CACNA1E CACNA1S ORAI2 RYR3	1.43e-04	151	66	5	GO:0015085
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B CACNA1E CACNA1S SLC39A12 ABCC8 KCNN2 ORAI2 RYR3	1.43e-04	465	66	8	GO:0046873
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1B CACNA1E CACNA1S ABCC8 KCNN2	1.47e-04	152	66	5	GO:0022843
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1B GABRG3 CACNA1E CACNA1S SLC39A12 ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	2.59e-04	793	66	10	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1B CACNA1E CACNA1S SLC39A12 ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	3.21e-04	664	66	9	GO:0008324
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1B CACNA1E CACNA1S ABCC8 KCNN2	3.39e-04	182	66	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1B CACNA1E CACNA1S ABCC8 KCNN2	3.57e-04	184	66	5	GO:0022832
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1B CACNA1E	3.82e-04	9	66	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1B CACNA1E	3.82e-04	9	66	2	GO:0099626
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1B GABRG3 CACNA1E CACNA1S SLC39A12 ABCA3 ABCA5 ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	4.34e-04	1180	66	12	GO:0022857
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1B CACNA1E CACNA1S	4.73e-04	46	66	3	GO:0005245
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA3 ABCA5 ABCC8	5.70e-04	49	66	3	GO:0140359
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1B GABRG3 CACNA1E CACNA1S SLC39A12 ABCC8 KCNN2 ORAI2 RYR3	8.32e-04	758	66	9	GO:0015318
GeneOntologyMolecularFunction	transporter activity	CACNA1B GABRG3 CACNA1E CACNA1S SLC39A12 ABCA3 ABCA5 ABCC8 PIEZO1 KCNN2 ORAI2 RYR3	9.50e-04	1289	66	12	GO:0005215
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B CACNA1E CACNA1S SLC39A12 ABCC8 KCNN2 ORAI2 RYR3	1.04e-03	627	66	8	GO:0022890
GeneOntologyMolecularFunction	microtubule minus-end binding	TUBGCP3 TUBGCP5	1.10e-03	15	66	2	GO:0051011
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF27	2.54e-03	82	66	3	GO:1990756
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRG3 ABCC8 KCNN2 RYR3	3.82e-03	193	66	4	GO:0015276
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF27	3.84e-03	95	66	3	GO:0140767
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	ABCC8 KCNN2	3.85e-03	28	66	2	GO:0005242
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRG3 ABCC8 KCNN2 RYR3	4.11e-03	197	66	4	GO:0022834
GeneOntologyCellularComponent	calcium channel complex	CACNA1B CACNA1E CACNA1S RYR3	7.89e-05	73	65	4	GO:0034704
GeneOntologyCellularComponent	equatorial microtubule organizing center	TUBGCP3 TUBGCP5	9.46e-05	5	65	2	GO:0000923
GeneOntologyCellularComponent	cell division site	PLEKHG6 TUBGCP3 TUBGCP5 MEN1	1.13e-04	80	65	4	GO:0032153
GeneOntologyCellularComponent	sarcolemma	CACNA1S DST ABCC8 KCNN2 RYR3	3.12e-04	190	65	5	GO:0042383
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1B CACNA1E CACNA1S	3.96e-04	46	65	3	GO:0005891
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 PRAMEF27	4.22e-04	47	65	3	GO:0031462
GeneOntologyCellularComponent	cation channel complex	CACNA1B CACNA1E CACNA1S ABCC8 RYR3	8.21e-04	235	65	5	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1B GABRG3 CACNA1E CACNA1S ABCC8 RYR3	1.13e-03	378	65	6	GO:0034702
GeneOntologyCellularComponent	I band	CACNA1S DST KCNN2 RYR3	1.78e-03	166	65	4	GO:0031674
GeneOntologyCellularComponent	gamma-tubulin complex	TUBGCP3 TUBGCP5	1.92e-03	21	65	2	GO:0000930
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGB DST SGMS1 OTOF MARCHF5 PIEZO1 SPTLC1 SREBF2 NOX4 RYR3 PHTF1	1.99e-03	1293	65	11	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGB DST SGMS1 OTOF MARCHF5 PIEZO1 SPTLC1 SREBF2 NOX4 RYR3 PHTF1	2.06e-03	1299	65	11	GO:0098827
Domain	VDCC_a1su_IQ	CACNA1B CACNA1E CACNA1S	1.27e-06	7	63	3	IPR014873
Domain	GPHH	CACNA1B CACNA1E CACNA1S	1.27e-06	7	63	3	PF16905
Domain	GPHH_dom	CACNA1B CACNA1E CACNA1S	1.27e-06	7	63	3	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1E CACNA1S	1.27e-06	7	63	3	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1E CACNA1S	1.27e-06	7	63	3	PF08763
Domain	VDCCAlpha1	CACNA1B CACNA1E CACNA1S	4.32e-06	10	63	3	IPR002077
Domain	Pecanex_C	PCNX3 PCNX1	6.69e-05	4	63	2	PF05041
Domain	Pecanex	PCNX3 PCNX1	6.69e-05	4	63	2	IPR007735
Domain	GCP	TUBGCP3 TUBGCP5	1.11e-04	5	63	2	IPR007259
Domain	Spc97_Spc98	TUBGCP3 TUBGCP5	1.11e-04	5	63	2	PF04130
Domain	ABC_transporter_CS	ABCA3 ABCA5 ABCC8	3.82e-04	42	63	3	IPR017871
Domain	EF-hand-dom_pair	CACNA1B CACNA1S DST USP32 STAT3 RYR3	4.07e-04	287	63	6	IPR011992
Domain	ABC_tran	ABCA3 ABCA5 ABCC8	5.68e-04	48	63	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA3 ABCA5 ABCC8	5.68e-04	48	63	3	PS50893
Domain	Ion_trans_dom	CACNA1B CACNA1E CACNA1S RYR3	5.94e-04	114	63	4	IPR005821
Domain	Ion_trans	CACNA1B CACNA1E CACNA1S RYR3	5.94e-04	114	63	4	PF00520
Domain	ABC_TRANSPORTER_1	ABCA3 ABCA5 ABCC8	6.03e-04	49	63	3	PS00211
Domain	ABC_transporter-like	ABCA3 ABCA5 ABCC8	6.40e-04	50	63	3	IPR003439
Domain	ABC_A	ABCA3 ABCA5	7.23e-04	12	63	2	IPR026082
Domain	Channel_four-helix_dom	CACNA1B CACNA1E CACNA1S	9.40e-04	57	63	3	IPR027359
Domain	-	CACNA1B CACNA1E CACNA1S	9.40e-04	57	63	3	1.20.120.350
Domain	ARM-type_fold	NEK10 ZNFX1 HEATR5A RALGAPA2 TARBP1 RYR3	9.74e-04	339	63	6	IPR016024
Domain	EF_HAND_2	CACNA1B CACNA1E DST USP32 RYR3	1.09e-03	231	63	5	PS50222
Domain	EF_hand_dom	CACNA1B CACNA1E DST USP32 RYR3	1.11e-03	232	63	5	IPR002048
Domain	PRAME_family	PRAMEF15 PRAMEF27	1.85e-03	19	63	2	IPR026271
Domain	BHLH	SREBF2 NEUROD6 PHTF1	7.24e-03	117	63	3	PS50888
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1B CACNA1E CACNA1S RYR3	2.21e-08	11	42	4	M47958
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1B CACNA1E CACNA1S	4.18e-05	23	42	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1B CACNA1E CACNA1S	5.40e-05	25	42	3	M47948
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1B CACNA1E CACNA1S ADCY2 RYR3	7.18e-05	147	42	5	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1B CACNA1E CACNA1S ADCY2 RYR3	8.15e-05	151	42	5	M39329
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1B CACNA1S	1.29e-04	6	42	2	M47762
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1B CACNA1E CACNA1S ADCY2 RYR3	1.77e-04	178	42	5	M2890
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1E ACACA ABCC8 ADCY2	2.91e-04	108	42	4	M17034
Pathway	KEGG_ABC_TRANSPORTERS	ABCA3 ABCA5 ABCC8	2.99e-04	44	42	3	M11911
Pathway	WP_15Q112_COPY_NUMBER_VARIATION_SYNDROME	TUBGCP3 TUBGCP5	3.08e-04	9	42	2	M39879
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	CACNA1B CACNA1E ABCC8	3.64e-04	47	42	3	M19708
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNA1E	4.69e-04	11	42	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNA1E	4.69e-04	11	42	2	M26913
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1E CACNA1S	3.63e-07	8	66	3	28330839
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1E CACNA1S	5.44e-07	9	66	3	16382099
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNA1E CACNA1S	2.92e-06	15	66	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1B CACNA1E CACNA1S	2.92e-06	15	66	3	24453333
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	3.55e-06	2	66	2	15610184
Pubmed	Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity.	OTOF KCNN2	3.55e-06	2	66	2	23650376
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	3.55e-06	2	66	2	12074836
Pubmed	Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression.	COPS5 STAT3	3.55e-06	2	66	2	27524414
Pubmed	JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells.	COPS5 STAT3	3.55e-06	2	66	2	23911788
Pubmed	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.	ACACA SREBF2 STAT3	3.59e-06	16	66	3	8833906
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1B CACNA1E CACNA1S ABCC8 KCNN2	6.97e-06	139	66	5	16985003
Pubmed	The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.	COPS5 STAT3	1.06e-05	3	66	2	27693579
Pubmed	Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.	COPS5 STAT3	1.06e-05	3	66	2	21689417
Pubmed	Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway.	SGMS1 STAT3	1.06e-05	3	66	2	35230716
Pubmed	Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.	STAT3 MEN1	1.06e-05	3	66	2	25136117
Pubmed	Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.	CACNA1E ABCC8	1.06e-05	3	66	2	16924481
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1B CACNA1E	1.06e-05	3	66	2	38996073
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1B CACNA1E	1.06e-05	3	66	2	24523520
Pubmed	NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.	NOX4 STAT3	1.06e-05	3	66	2	23049784
Pubmed	Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination.	ACACA SREBF2	1.06e-05	3	66	2	12668174
Pubmed	Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation.	NOX4 STAT3	1.06e-05	3	66	2	29459227
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1B CACNA1E	2.12e-05	4	66	2	32616470
Pubmed	Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells.	NOX4 STAT3	2.12e-05	4	66	2	25504436
Pubmed	Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.	CACNA1S ABCC8	2.12e-05	4	66	2	14660679
Pubmed	R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.	CACNA1E ABCC8	2.12e-05	4	66	2	17369816
Pubmed	Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.	ABCA3 SREBF2	2.12e-05	4	66	2	17890326
Pubmed	Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways.	COPS5 STAT3	2.12e-05	4	66	2	33707115
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1B CACNA1E	2.12e-05	4	66	2	37141091
Pubmed	DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.	SFR1 STAT3	2.12e-05	4	66	2	23874500
Pubmed	Characterization of the mouse JAB1 cDNA and protein.	DST COPS5	2.12e-05	4	66	2	10721695
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1B CACNA1E	3.53e-05	5	66	2	8825650
Pubmed	GCP5 and GCP6: two new members of the human gamma-tubulin complex.	TUBGCP3 TUBGCP5	3.53e-05	5	66	2	11694571
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1E	3.53e-05	5	66	2	15451373
Pubmed	Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells.	NOX4 STAT3	3.53e-05	5	66	2	19834108
Pubmed	ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer.	ABCA3 ABCC8	3.53e-05	5	66	2	28468577
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1E	3.53e-05	5	66	2	11296258
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RADX TUBGCP3 SPTLC1 TARBP1	4.72e-05	104	66	4	31240132
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1B CACNA1E RYR3	5.25e-05	38	66	3	30786075
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1B CACNA1E	5.29e-05	6	66	2	35324301
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	CACNA1S RYR3	5.29e-05	6	66	2	10444070
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1B CACNA1E	5.29e-05	6	66	2	12827191
Pubmed	Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway.	COPS5 STAT3	5.29e-05	6	66	2	31802034
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1B CACNA1E	5.29e-05	6	66	2	9238069
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1E CACNA1S	7.40e-05	7	66	2	12900400
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B CACNA1E	7.40e-05	7	66	2	35176221
Pubmed	Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.	OAS3 STAT3	9.86e-05	8	66	2	19667218
Pubmed	Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.	ABCA3 SPTLC1	9.86e-05	8	66	2	24293640
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	ORAI2 RYR3	9.86e-05	8	66	2	30563862
Pubmed	Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.	TUBGCP3 TUBGCP5	1.27e-04	9	66	2	11956313
Pubmed	Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.	TUBGCP3 TUBGCP5	1.27e-04	9	66	2	8838651
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	CACNA1S RYR3	1.27e-04	9	66	2	21858002
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DST OTOF USP32 ZNFX1 TUBGCP5 NEUROD6 COPS5 TARBP1 STAT3 RYR3	1.47e-04	1285	66	10	35914814
Pubmed	CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex.	TUBGCP3 TUBGCP5	1.58e-04	10	66	2	21135143
Pubmed	A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.	PCNX3 COPS5 MEN1	1.60e-04	55	66	3	34237211
Pubmed	Nucleotide sequence of mouse spermidine synthase cDNA.	ACACA SREBF2	2.73e-04	13	66	2	7803821
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DST ABCA5 PIEZO1 VPS50 PCNX1 ARHGAP20	5.05e-04	529	66	6	14621295
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	ACACA SREBF2	5.94e-04	19	66	2	26685326
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	ACACA STAT3	6.59e-04	20	66	2	18227155
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF15 PRAMEF27	6.59e-04	20	66	2	26694250
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF15 STAT3	6.59e-04	20	66	2	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF27	7.99e-04	22	66	2	31729367
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA SREBF2	7.99e-04	22	66	2	20965718
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA3 ABCC8	8.75e-04	23	66	2	10708515
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	ACACA SREBF2	8.75e-04	23	66	2	26508642
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACA SREBF2	8.75e-04	23	66	2	14662765
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	NEPRO SGMS1 PTAR1 SPTLC1	9.58e-04	229	66	4	26472760
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	NEPRO ACACA MINK1 SPTLC1 STAT3	9.76e-04	399	66	5	37536630
Pubmed	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.	ABCA3 SREBF2	1.03e-03	25	66	2	30604742
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF15 PRAMEF27	1.03e-03	25	66	2	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF15 STAT3	1.12e-03	26	66	2	18500982
Pubmed	Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.	ADGRE3 CD101 SERPING1	1.16e-03	108	66	3	23383108
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	SLC39A12 SGMS1 HPS1 SFR1 TMEM26	1.16e-03	415	66	5	16385451
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	SGMS1 SPTLC1	1.21e-03	27	66	2	23096701
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	CACNA1S NEUROD6	1.21e-03	27	66	2	37995181
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	SGMS1 SPTLC1	1.21e-03	27	66	2	25269881
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	DST ACACA MINK1 SPTLC1 RALGAPA2	1.24e-03	421	66	5	36976175
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF15 PRAMEF27	1.30e-03	28	66	2	25089626
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	SERPING1 CR1	1.59e-03	31	66	2	19344414
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	CACNA1E PCNX1	1.59e-03	31	66	2	27321927
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	CACNA1B CACNA1E	1.70e-03	32	66	2	19320717
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	SERPING1 CR1	1.70e-03	32	66	2	18842294
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	DST ACACA SPTLC1 SFR1 COPS5	1.71e-03	453	66	5	27113764
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	ACACA STAT3	1.80e-03	33	66	2	26296893
Pubmed	The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.	CACNA1B CACNA1S	1.80e-03	33	66	2	22357600
Cytoband	1p13	CD101 PHTF1	2.73e-04	17	66	2	1p13
GeneFamily	PRAME family	PRAMEF9 PRAMEF15 PRAMEF27	2.28e-05	24	42	3	686
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNA1E CACNA1S	2.92e-05	26	42	3	253
GeneFamily	EF-hand domain containing	CACNA1B CACNA1E DST USP32 RYR3	1.47e-04	219	42	5	863
GeneFamily	UPF1 like RNA helicases	ZNFX1 MOV10	2.86e-04	11	42	2	1169
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA5	4.71e-04	14	42	2	805
Coexpression	GSE6269_HEALTHY_VS_FLU_INF_PBMC_DN	ACACA MINK1 HPS1 SREBF2 SERPING1 OAS3 ADCY2	1.63e-07	163	65	7	M5640
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	CACNA1B CACNA1E ABCA5 ABCC8 TARBP1 RYR3	3.57e-06	166	65	6	M39026
Coexpression	ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_3DY_UP	CD101 SERPING1 OAS3 ZNFX1 MOV10	1.88e-05	131	65	5	M40875
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	OTOF SERPING1 OAS3 ZNFX1 MOV10	9.97e-06	193	66	5	22455801194bd8c73c5c397f5eac4f723429c383
ToppCell	control-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OTOF SERPING1 OAS3 ZNFX1 MOV10	1.02e-05	194	66	5	267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 ABCA5 TARBP1 PHTF1	1.13e-05	198	66	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DST PLEKHG6 PIEZO1 SERPING1	8.07e-05	154	66	4	6c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCell	PBMC-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	OTOF NEK10 SERPING1 OAS3	8.48e-05	156	66	4	9b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DST OTOF CD101 OAS3	8.69e-05	157	66	4	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DST OTOF CD101 OAS3	8.91e-05	158	66	4	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CACNA1E OTOF ORAI2 RYR3	9.35e-05	160	66	4	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CACNA1E OTOF ORAI2 RYR3	9.58e-05	161	66	4	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1B GABRG3 CACNA1E NOX4	1.10e-04	167	66	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA5 KCNN2 SERPING1 SFR1	1.10e-04	167	66	4	b0eb7a40491dd2432f5282f578ce569df86d21a7
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEK10 ORAI2 NEUROD6 RYR3	1.13e-04	168	66	4	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1S DST CR1 RYR3	1.13e-04	168	66	4	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1S DST CR1 RYR3	1.13e-04	168	66	4	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1B CACNA1E ABCC8 ADCY2	1.15e-04	169	66	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	DST ABCA5 USP32 SPTLC1	1.29e-04	174	66	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1E OTOF TMEM26 TARBP1	1.29e-04	174	66	4	c529f3674b784f872f4387ffdeb46aecb619976b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S OAS3 ORAI2	1.41e-04	178	66	4	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S OAS3 ORAI2	1.41e-04	178	66	4	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S OAS3 ORAI2	1.41e-04	178	66	4	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	GPR155 OAS3 ZNFX1 MOV10	1.44e-04	179	66	4	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	COVID-19_Mild-CD4+_T_activated\|COVID-19_Mild / Disease condition and Cell class	NEPRO DST OAS3 PCNX1	1.54e-04	182	66	4	877b6e611626628e709568747512f2827ebb2795
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG3 CACNA1E ARHGAP20 RYR3	1.54e-04	182	66	4	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG3 CACNA1E ARHGAP20 RYR3	1.54e-04	182	66	4	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCC8 SPTLC1 OAS3 RPSA	1.54e-04	182	66	4	3fddadb2ff75013ec6eeb415872667a6bae1da2d
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B CACNA1E ABCA3 ABCC8	1.74e-04	188	66	4	bd091503f580dedab40e0996273101285d24b586
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GPR155 OAS3 ZNFX1 MOV10	1.74e-04	188	66	4	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CACNA1E ADGRE3 SERPING1 CR1	1.74e-04	188	66	4	aa46073e2940dc1d2020b2e259bf0fc06cb990ee
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CACNA1E ADGRE3 SERPING1 CR1	1.74e-04	188	66	4	04814b78da936a51a497e23060d19ca0d619e250
ToppCell	ILEUM-non-inflamed-(2)_Memory_B_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PLEKHG7 RPSA CR1 ORAI2	1.77e-04	189	66	4	8d9b8a952db78646f137526f3175ba502f1d3692
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LVRN SERPING1 ARHGAP20 ADCY2	1.77e-04	189	66	4	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LVRN SERPING1 ARHGAP20 ADCY2	1.77e-04	189	66	4	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LVRN SERPING1 ARHGAP20 ADCY2	1.77e-04	189	66	4	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	ILEUM-inflamed-(2)_B_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PLEKHG7 RPSA CR1 ORAI2	1.85e-04	191	66	4	0aa913678456b7d525bd177588f2463f6ed76cd7
ToppCell	ILEUM-non-inflamed-(2)_B_cell\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PLEKHG7 RPSA CR1 ORAI2	1.85e-04	191	66	4	d4496994dd973eb6d0d8b9101a390af237e12fb2
ToppCell	BAL-Mild\|BAL / Compartment, Disease Groups and Clusters	SERPING1 OAS3 ZNFX1 MOV10	1.88e-04	192	66	4	1a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCell	ILEUM-inflamed-(2)_Memory_B_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PLEKHG7 RPSA CR1 ORAI2	1.88e-04	192	66	4	4f82913e9ae8ab6dd3e8885a0a7f4dca92e318e1
ToppCell	COVID-19-Myeloid-TRAM1\|COVID-19 / Condition, Lineage and Cell class	DST ADGRE3 CD101 SERPING1	1.88e-04	192	66	4	52b8578699325b0d35a2d3ba36772096130ccc0c
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	PTAR1 USP32 PCNX1 HEATR5A	1.92e-04	193	66	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Mild_COVID-19\|World / Disease group,lineage and cell class （2021.01.30）	GPR155 MINK1 OAS3 ZNFX1	1.92e-04	193	66	4	325b0768827bf8701bfb7f686bb11fd8b1a41a5c
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	OTOF OAS3 ZNFX1 STAT3	1.96e-04	194	66	4	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GABRG3 DST ARHGAP20 ADCY2	1.96e-04	194	66	4	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PLEKHG7 OAS3 ZNFX1 MOV10	2.00e-04	195	66	4	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LVRN DST SERPING1 NOX4	2.00e-04	195	66	4	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 ABCA5 TARBP1	2.04e-04	196	66	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	GPR155 OAS3 ZNFX1 TARBP1	2.04e-04	196	66	4	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	COPD-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	NEK10 PCNX1 STAT3 PHTF1	2.04e-04	196	66	4	c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCell	COVID-19_Moderate-Classical_Monocyte\|World / disease group, cell group and cell class	OTOF SERPING1 OAS3 CR1	2.08e-04	197	66	4	16cf3939e700aef1e16159f0652ba2dfad287e7a
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	GPR155 OTOF OAS3 ZNFX1	2.12e-04	198	66	4	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	COVID-19_Moderate-Non-classical_Monocyte\|World / disease group, cell group and cell class	OTOF CD101 SERPING1 OAS3	2.12e-04	198	66	4	8449934e20bb2a34079fb642cae0d4647b9efe51
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 ABCA5 ADCY2	2.12e-04	198	66	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 ABCA5 TARBP1	2.12e-04	198	66	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	BAL-Severe\|BAL / Compartment, Disease Groups and Clusters	OTOF SERPING1 OAS3 ZNFX1	2.12e-04	198	66	4	f63cfcc57f46094ea0673bbc70ea443ebaca6176
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B GABRG3 ABCA5 TARBP1	2.12e-04	198	66	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	mLN-(6)_Macrophage-(60)_Macrophage\|mLN / shred on region, Cell_type, and subtype	PLEKHG6 ABCC8 SERPING1 TMEM26	2.16e-04	199	66	4	1ea28b832c6173b1b58da432aaf21e6cd291561e
ToppCell	mLN-Macrophage-Macrophage\|mLN / Region, Cell class and subclass	PLEKHG6 ABCC8 SERPING1 TMEM26	2.16e-04	199	66	4	6bbec8450afb30347b07da28401a698fc51a3c53
ToppCell	Sepsis-Int-URO-Lymphocyte-B-B_memory\|Int-URO / Disease, condition lineage and cell class	NEK10 PLEKHG7 RPSA ORAI2	2.16e-04	199	66	4	7cddf15aeb65df17f737bb3144d6579ec5a1ea27
ToppCell	Caecum-B_cell-B_cell_memory\|Caecum / Region, Cell class and subclass	PLEKHG7 RPSA CR1 ORAI2	2.20e-04	200	66	4	5a954d366762c6838cc6ec3ae05ed908e5f120b5
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	OTOF NEK10 PLEKHG7 ADCY2	2.20e-04	200	66	4	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1B GABRG3 ABCA5 TARBP1	2.20e-04	200	66	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Caecum-(2)_B_cell-(22)_B_cell_memory\|Caecum / shred on region, Cell_type, and subtype	PLEKHG7 RPSA CR1 ORAI2	2.20e-04	200	66	4	8e71f3518cde586fe0b8dfa3f6ee57e85e10ad4e
ToppCell	(22)_B_cell_memory\|World / shred on Cell_type and subtype	PLEKHG7 RPSA CR1 ORAI2	2.33e-04	203	66	4	94ac418c9bfef1ce2e000a9c4117485651dfe85a
Drug	AC1L2AC7	CACNA1B CACNA1E CACNA1S HPS1 RYR3	1.35e-06	69	63	5	CID000068733
Drug	CAS 298-57-7	CACNA1B CACNA1E CACNA1S SERPING1 RYR3	1.79e-06	73	63	5	CID000002761
Drug	CNS 1145	CACNA1B CACNA1E CACNA1S RYR3	2.05e-06	33	63	4	CID000190902
Drug	IHC-64	CACNA1B CACNA1E CACNA1S RYR3	2.05e-06	33	63	4	CID000162753
Drug	norcepharadione B	CACNA1B CACNA1E	7.54e-06	2	63	2	CID000189168
Drug	aristolactam AII	CACNA1B CACNA1E	7.54e-06	2	63	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	7.54e-06	2	63	2	CID005488638
Drug	piperolactam A	CACNA1B CACNA1E	7.54e-06	2	63	2	CID003081016
Drug	papaverine	CACNA1B CACNA1E CACNA1S DST ABCC8 RYR3	9.24e-06	176	63	6	CID000004680
Drug	baclofen	CACNA1B GABRG3 CACNA1E CACNA1S ADCY2 RYR3	1.47e-05	191	63	6	CID000002284
Drug	Cinildipine	CACNA1B CACNA1E CACNA1S RYR3	1.75e-05	56	63	4	CID000002752
Drug	AC1NBU2S	CACNA1B CACNA1E CACNA1S HPS1 RYR3	1.82e-05	117	63	5	CID004473765
Drug	N6-Me-dAdo	CACNA1B CACNA1E STAT3	1.90e-05	19	63	3	CID000168948
Drug	stearoyl-coenzyme A	ACACA HPS1 SPTLC1 SREBF2 STAT3	2.23e-05	122	63	5	CID000001106
Drug	nilvadipine	CACNA1B CACNA1E CACNA1S RYR3	2.31e-05	60	63	4	CID000004494
Drug	IAA-94	CACNA1B CACNA1E CACNA1S RYR3	2.47e-05	61	63	4	CID000003667
Drug	pimozide	CACNA1B CACNA1E CACNA1S ABCC8 RYR3	2.71e-05	127	63	5	CID000016362
Drug	lercanidipine	CACNA1B CACNA1E CACNA1S RYR3	2.80e-05	63	63	4	CID000065866
Drug	gallopamil	CACNA1B CACNA1E CACNA1S RYR3	3.58e-05	67	63	4	CID000001234
Drug	lanthanum	CACNA1B CACNA1E CACNA1S ADCY2 RYR3	3.76e-05	136	63	5	CID000023926
Drug	AC 110	CACNA1B CACNA1E	4.51e-05	4	63	2	CID000022860
Drug	nimodipine	CACNA1B GABRG3 CACNA1E CACNA1S RYR3	5.11e-05	145	63	5	CID000004497
Drug	ethosuximide	CACNA1B CACNA1E CACNA1S RYR3	5.30e-05	74	63	4	CID000003291
Drug	verapamil	CACNA1B CACNA1E CACNA1S ABCA3 ABCA5 KCNN2 ADCY2 RYR3	5.96e-05	490	63	8	CID000002520
Drug	Bay K 8644	CACNA1B CACNA1E CACNA1S HPS1 RYR3	6.00e-05	150	63	5	CID000002303
Drug	nisoldipine	CACNA1B CACNA1E CACNA1S RYR3	6.51e-05	78	63	4	CID000004499
Drug	procaine	CACNA1B GABRG3 CACNA1E CACNA1S RYR3	6.59e-05	153	63	5	CID000004914
Drug	lindane	CACNA1B GABRG3 CACNA1E CACNA1S RYR3	6.80e-05	154	63	5	CID000000727
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1B CACNA1E CACNA1S RYR3	6.84e-05	79	63	4	CID005287890
Drug	almagel	CACNA1B CACNA1E	7.50e-05	5	63	2	CID003080942
Drug	XeC compound	CACNA1B CACNA1E CACNA1S RYR3	8.70e-05	84	63	4	CID000005701
Drug	3-aminopropylphosphinic acid	CACNA1B GABRG3 CACNA1E	9.46e-05	32	63	3	CID006335948
Drug	gabapentin	CACNA1B GABRG3 CACNA1E CACNA1S RYR3	1.05e-04	169	63	5	CID000003446
Drug	chloro-m-cresol	CACNA1S RYR3	1.12e-04	6	63	2	CID000012008
Drug	3,4-dihydroquinazoline	CACNA1B CACNA1E	1.12e-04	6	63	2	CID000583065
Drug	NSC114784	CACNA1S RYR3	1.12e-04	6	63	2	CID000419425
Drug	alpha-sialylcholesterol	CACNA1B CACNA1E	1.12e-04	6	63	2	CID000133976
Drug	AC1Q6L57	CACNA1B CACNA1E SERPING1	1.14e-04	34	63	3	CID000090740
Drug	riluzole	CACNA1B GABRG3 CACNA1E CACNA1S RYR3	1.21e-04	174	63	5	CID000005070
Drug	manidipine	CACNA1B CACNA1E CACNA1S RYR3	1.40e-04	95	63	4	CID000004008
Drug	isotetrandrine	CACNA1B CACNA1E CACNA1S RYR3	1.52e-04	97	63	4	CID000005422
Drug	Amlodipine	CACNA1B CACNA1S	1.57e-04	7	63	2	DB00381
Drug	APMPA	CACNA1B CACNA1E	1.57e-04	7	63	2	CID000512300
Drug	nitrendipine	CACNA1B CACNA1E CACNA1S RYR3	1.58e-04	98	63	4	CID000004507
Drug	isradipine	CACNA1B CACNA1E CACNA1S RYR3	1.71e-04	100	63	4	CID000003784
Drug	epps	CACNA1B CACNA1E RYR3	1.85e-04	40	63	3	CID000085255
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; MCF7; HT_HG-U133A	MINK1 HPS1 VPS50 PCNX1 CR1	1.87e-04	191	63	5	2824_UP
Drug	NSC759576	CACNA1B CACNA1E CACNA1S ADCY2 RYR3	1.87e-04	191	63	5	CID000003075
Drug	dihydropyridine	CACNA1B CACNA1E CACNA1S HPS1 RYR3	1.96e-04	193	63	5	CID000104822
Drug	Carbarsone [121-59-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A	MINK1 HPS1 VPS50 KCNN2 PCNX1	1.96e-04	193	63	5	3250_UP
Drug	AC1L1I54	CACNA1B CACNA1E ADCY2	2.00e-04	41	63	3	CID000004426
Drug	Dacarbazine [4342-03-4]; Down 200; 22uM; HL60; HG-U133A	ACACA SPTLC1 PCNX1 CR1 STAT3	2.06e-04	195	63	5	1762_DN
Drug	Etomidate [33125-97-2]; Down 200; 16.4uM; MCF7; HT_HG-U133A	MINK1 HPS1 SREBF2 PCNX1 STAT3	2.06e-04	195	63	5	3519_DN
Drug	loperamide	CACNA1B CACNA1E CACNA1S RYR3	2.06e-04	105	63	4	CID000003954
Drug	AC1L1EOW	CACNA1E STAT3	2.09e-04	8	63	2	CID000002885
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; MCF7; HT_HG-U133A	PLEKHG6 MINK1 TUBGCP3 SREBF2 KCNN2	2.26e-04	199	63	5	5014_DN
Drug	halothane	CACNA1B GABRG3 CACNA1E CACNA1S ADCY2 RYR3	2.30e-04	314	63	6	CID000003562
Drug	CGP 28392	CACNA1S HPS1	2.68e-04	9	63	2	CID000123861
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1B CACNA1E	1.34e-05	3	63	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1B CACNA1E	2.68e-05	4	63	2	DOID:6364 (implicated_via_orthology)
Disease	hereditary sensory neuropathy (implicated_via_orthology)	DST SPTLC1	4.47e-05	5	63	2	DOID:0050548 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1B CACNA1E	9.36e-05	7	63	2	DOID:0050951 (implicated_via_orthology)
Disease	DIABETES MELLITUS, PERMANENT NEONATAL	ABCC8 STAT3	9.36e-05	7	63	2	C1833104
Disease	Pulmonary Fibrosis	ABCA3 HPS1 STAT3	8.09e-04	85	63	3	C0034069
Disease	Idiopathic Pulmonary Fibrosis	ABCA3 STAT3	9.18e-04	21	63	2	C1800706
Disease	response to paliperidone, schizophrenia symptom severity measurement	CACNA1B CACNA1S ADGRE3 CR1	1.19e-03	216	63	4	EFO_0007925, EFO_0007927
Disease	Neonatal diabetes mellitus	ABCC8 STAT3	1.30e-03	25	63	2	C0158981
Disease	respiratory failure, COVID-19	DST OAS3	1.76e-03	29	63	2	EFO_0009686, MONDO_0100096
Disease	diastolic blood pressure, alcohol drinking	SLC39A12 NEK10 MOV10	2.08e-03	118	63	3	EFO_0004329, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
WRQTRTLLLKNYLIK	ABCA5	11	Q8WWZ7
SSLDRKLLELLWNKY	COPS5	231	Q92905
LLRIFKITKYWASLR	CACNA1E	576	Q15878
QLALLLWKNYTLQKR	ABCA3	6	Q99758
YWRLRRLLLEDLVKK	ACACA	2216	Q13085
SLLKRYLLKRLNLIW	LVRN	746	Q6Q4G3
IKLLRQGYTIRILLW	CACNA1B	1576	Q00975
QALSWRKLYLSRAKL	ORAI2	46	Q96SN7
LLQLQQKLLWLLYDL	MEN1	261	O00255
WYKSLRVGLVLLLQD	RADX	286	Q6NSI4
WSLAILLLSKKYKQL	GPR155	396	Q7Z3F1
VLRETWLIYKNTKLV	KCNN2	426	Q9H2S1
KLLEIWIEFGRIKLL	DST	336	Q03001
SILFNKLWELLYKLQ	PCNX1	1441	Q96RV3
LCSKLWDLLYKLRFV	PCNX3	1231	Q9H6A9
LWKIFIQLCLALRYL	NEK10	631	Q6ZWH5
LTYLLLWVKQRKDLL	PRAMEF15	166	P0DUQ1
LRLWRKYSNKLQILN	MARCHF5	166	Q9NX47
VLKNKWSILYLLLSL	TUBGCP3	86	Q96CW5
LLLLQIKWAKYSLDV	TUBGCP5	826	Q96RT8
LWYKLAKIRDNLAIS	RALGAPA2	961	Q2PPJ7
CRKLGLLLKYILDSW	IRGC	441	Q6NXR0
ILNTLLDDWKPYKLR	NOX4	441	Q9NPH5
LWELLTTELIYVRKL	PLEKHG6	166	Q3KR16
VFKKLLRLFSLVIWI	ADCY2	101	Q08462
LLLLLLISLLCLYWK	CD101	966	Q93033
LISLLCLYWKARKLS	CD101	971	Q93033
IFEWLRYLEKLLLAT	HEATR5A	26	Q86XA9
LLIIFLSWIILKHRK	CR1	1986	P17927
LRIWNDGKILYTLRL	GABRG3	151	Q99928
RLLRIFKITKYWTSL	CACNA1S	531	Q13698
RLVLLNAIYLSAKWK	SERPING1	286	P05155
KVWSLIQLARRYLQK	HPS1	581	Q92902
WLSLLLLAIYEQNIK	SLC39A12	676	Q504Y0
TYRWLLLKLLLLLLL	OTOF	1961	Q9HC10
VKLKNLILLVKHWYR	OAS3	596	Q9Y6K5
KLRVYYLSWLRNKIL	MINK1	1081	Q8N4C8
WLSLLQRYINLEKEK	ARHGAP20	176	Q9P2F6
KRYRILLVTVLWTLL	PIGB	336	Q92521
IYIINLKRTWEKLLL	RPSA	46	P08865
YLKWRVKKVVLVLLL	TAS2R14	121	Q9NYV8
KLRQASLSVLLWLRY	TAS2R14	286	Q9NYV8
KKEPRYWLLALLNLL	TMEM26	31	Q6ZUK4
KLLLYRTRKQWLNRD	PTAR1	71	Q7Z6K3
LKWRNYEVKLRLLLH	MOV10	331	Q9HCE1
EWLLRKSSLLKKYLL	RIMOC1	151	A6NDU8
SRLWVLYKGVLKRLI	NEPRO	181	Q6NW34
LTYLLLWVKQRKDLL	PRAMEF27	166	A3QJZ7
LWYVLLKERNMLLTL	MRPL47	101	Q9HD33
LIKKWRSCSQLLLYE	SFR1	191	Q86XK3
LILWIIRLLFSKTYK	SPTLC1	31	O15269
IKLLKLYAWENIFRT	ABCC8	506	Q09428
VLFILVFWILKRKLS	ADGRE3	521	Q9BY15
RIWQDVQLKVKTYLL	VPS50	386	Q96JG6
KVENIKIWLSLRSYL	PHTF1	586	Q9UMS5
MAWKEILNLLYKLLA	RYR3	511	Q15413
DNIIDLVKKYILALW	STAT3	566	P40763
LTYLLLWVKQRKDLL	PRAMEF9	166	P0DUQ2
YSLQKLRLVRWLLKK	SREBF2	626	Q12772
QWLLLKYKSIISRRF	SGMS1	201	Q86VZ5
LWLQLYQADTRRKIL	ZNFX1	936	Q9P2E3
ISLLWALILYHNKLK	TMEM225	111	Q6GV28
LTRYPLLLKNIWKRS	PLEKHG7	441	Q6ZR37
FWLLLRQFVKEKLLK	PIEZO1	526	Q92508
VRLYALVALKKLWTV	TARBP1	1286	Q13395
LFLLLLLSNWLVKYE	TEX46	31	H3BTG2
IIDLEKRYWLLKAQS	USP32	196	Q8NFA0
LRLAKNYIWALSEIL	NEUROD6	136	Q96NK8