Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

1.32e-1071175GO:0004711
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF717 ZNF136 ZNF671 ZNF805 IRF3 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 PER2 ZFHX4 ZNF334 ZNF41 ZNF283 RBAK NCOA1 ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

1.10e-05145911723GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF717 ZNF136 ZNF671 ZNF805 IRF3 ZNF215 ZNF677 CTCFL ZNF776 ZNF23 PER2 ZFHX4 ZNF334 ZNF41 ZNF283 RBAK ZNF264 ZNF81 ZNF426

1.09e-04124411719GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF717 ZNF136 ZNF671 ZNF805 IRF3 ZNF215 ZNF677 CTCFL ZNF776 ZNF23 PER2 ZFHX4 ZNF334 ZNF41 ZNF283 RBAK ZNF264 ZNF81 ZNF426

1.44e-04127111719GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF717 ZNF136 ZNF805 IRF3 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

1.95e-04141211720GO:0000981
DomainKRAB

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 ZNF776 ZNF23 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

6.91e-1135811517PS50805
DomainKRAB

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 ZNF776 ZNF23 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

1.11e-1036911517SM00349
DomainKRAB

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 ZNF776 ZNF23 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

1.15e-1037011517IPR001909
DomainKRAB

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 ZNF776 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

6.37e-1035811516PF01352
DomainZnf_C2H2/integrase_DNA-bd

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

8.12e-0969411520IPR013087
DomainRibosomal_S6_kinase_II

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.03e-0861154IPR016239
Domain-

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

3.21e-08679115193.30.160.60
Domainzf-C2H2

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF426

4.44e-0869311519PF00096
DomainZINC_FINGER_C2H2_2

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

5.07e-0877511520PS50157
DomainZINC_FINGER_C2H2_1

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

5.29e-0877711520PS00028
DomainZnf_C2H2-like

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

7.85e-0879611520IPR015880
DomainZnf_C2H2

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

9.42e-0880511520IPR007087
DomainZnF_C2H2

ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZFHX4 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

1.00e-0780811520SM00355
DomainPkinase_C

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

3.02e-06371155IPR017892
DomainPkinase_C

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

5.75e-06421155PF00433
DomainBTK

TEC RASA4 RASA4B

1.86e-0591153SM00107
DomainZnf_Btk_motif

TEC RASA4 RASA4B

1.86e-0591153IPR001562
DomainBTK

TEC RASA4 RASA4B

1.86e-0591153PF00779
DomainZF_BTK

TEC RASA4 RASA4B

1.86e-0591153PS51113
DomainAGC-kinase_C

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

2.41e-05561155IPR000961
DomainAGC_KINASE_CTER

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

2.41e-05561155PS51285
DomainS_TK_X

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

2.41e-05561155SM00133
Domain-

RASA4 RASA4B

1.12e-04311524.10.1130.10
DomainC2

BCR RASA4 RASA4B PLCB4 FER1L5 CCDC33

1.60e-041311156PF00168
DomainC2

BCR RASA4 RASA4B PLCB4 FER1L5 CCDC33

2.04e-041371156SM00239
DomainKinesin-like_KIF1-typ

KIF1B KIF13A

2.24e-0441152IPR022140
DomainKIF1B

KIF1B KIF13A

2.24e-0441152PF12423
DomainC2

BCR RASA4 RASA4B PLCB4 FER1L5 CCDC33

2.48e-041421156PS50004
Domain-

BCR RASA4 RASA4B PLCB4 FER1L5 CCDC33

3.10e-0414811562.60.40.150
DomainC2_dom

BCR RASA4 RASA4B PLCB4 FER1L5 CCDC33

5.35e-041641156IPR000008
DomainKinesin_assoc

KIF1B KIF13A

5.55e-0461152PF16183
DomainKinesin-like

KIF1B KIF13A

5.55e-0461152IPR022164
DomainKinesin_assoc

KIF1B KIF13A

5.55e-0461152IPR032405
DomainDUF3694

KIF1B KIF13A

5.55e-0461152PF12473
Domainzf-C2H2_6

ZNF136 ZNF671 ZNF805 ZNF677 ZNF334 ZNF283 ZNF799 ZNF426

7.28e-043141158PF13912
DomainPROTEIN_KINASE_ATP

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 TEC TEK MAP3K3 RPS6KA6 LYN

2.14e-034591159PS00107
DomainRho_GTPase_activation_prot

MYO9A BCR RASA4 RASA4B

2.14e-03881154IPR008936
DomainProtein_kinase_ATP_BS

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 TEC TEK RPS6KA6 LYN

2.40e-033791158IPR017441
DomainProt_kinase_dom

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 TEC TEK MAP3K3 RPS6KA6 LYN

3.26e-034891159IPR000719
DomainRasGAP

RASA4 RASA4B

3.26e-03141152SM00323
DomainRasGAP_CS

RASA4 RASA4B

3.26e-03141152IPR023152
DomainPROTEIN_KINASE_DOM

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 TEC TEK MAP3K3 RPS6KA6 LYN

3.44e-034931159PS50011
DomainRasGAP

RASA4 RASA4B

3.74e-03151152PF00616
DomainRAS_GTPASE_ACTIV_1

RASA4 RASA4B

3.74e-03151152PS00509
DomainRAS_GTPASE_ACTIV_2

RASA4 RASA4B

3.74e-03151152PS50018
DomainSMAD_FHA_domain

KIF1B IRF3 KIF13A

4.04e-03521153IPR008984
DomainVWF_type-D

SUSD2 OTOG

4.26e-03161152IPR001846
DomainVWFD

SUSD2 OTOG

4.26e-03161152PS51233
DomainVWD

SUSD2 OTOG

4.26e-03161152SM00216
Domain-

RASA4 RASA4B

4.26e-031611521.10.506.10
DomainVWD

SUSD2 OTOG

4.26e-03161152PF00094
DomainPH_dom-like

KIF1B ALS2 TEC BCR WDFY4 RASA4 RASA4B PLCB4

4.86e-034261158IPR011993
DomainWD40

DMXL2 CHAF1B WDR76 WDFY4 WDR35 CORO7

5.37e-032591156PF00400
DomainTerpenoid_cyclase/PrenylTrfase

TCN2 C3

5.39e-03181152IPR008930
DomainRasGAP_dom

RASA4 RASA4B

5.39e-03181152IPR001936
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 TEC BCR LYN

2.09e-0936887M1315
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

7.05e-095884MM15108
PathwayKEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.11e-086884M47936
PathwayREACTOME_RSK_ACTIVATION

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

4.89e-087884M27369
PathwayKEGG_MTOR_SIGNALING_PATHWAY

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6 CAB39L

8.05e-0752886M7561
PathwayREACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

1.84e-0615884MM15103
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA1 RPS6KA2 RPS6KA3

8.08e-067883M27096
PathwayREACTOME_CREB_PHOSPHORYLATION

RPS6KA1 RPS6KA2 RPS6KA3

8.08e-067883MM14784
PathwaySA_B_CELL_RECEPTOR_COMPLEXES

RPS6KA1 RPS6KA3 BCR LYN

1.37e-0524884M17200
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.59e-0528884M837
PathwayWP_KIT_RECEPTOR_SIGNALING

RPS6KA1 RPS6KA3 RPS6KB1 TEC LYN

3.25e-0559885M39350
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.40e-0535884MM15109
PathwayKEGG_LONG_TERM_POTENTIATION

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 PLCB4

7.43e-0570885M3115
PathwayBIOCARTA_MAPK_PATHWAY

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 MAP3K3

1.10e-0476885MM1433
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA1 RPS6KA2 RPS6KA3

1.24e-0416883MM15477
PathwayBIOCARTA_MAPK_PATHWAY

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 MAP3K3

1.49e-0481885M13863
PathwayWP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 MAP3K3 RPS6KA6

1.74e-04132886M39338
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

RPS6KA1 RPS6KA2 RPS6KA3

1.79e-0418883M657
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA1 RPS6KA2 RPS6KA3

2.12e-0419883MM14780
PathwayWP_CYTOPLASMIC_RIBOSOMAL_PROTEINS

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

2.20e-0488885M39495
PathwayREACTOME_RECYCLING_PATHWAY_OF_L1

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.42e-0449884M891
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1

2.83e-0451884M7955
PathwayREACTOME_ERK_MAPK_TARGETS

RPS6KA1 RPS6KA2 RPS6KA3

3.32e-0422883M13408
PathwayWP_IL6_SIGNALING_PATHWAY

RPS6KA2 RPS6KB1 TEC NCOA1 LYN

3.99e-04100885MM15826
PathwayWP_INSULIN_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 MAP3K3 RPS6KA6

4.90e-04160886MM15956
PathwayWP_INSULIN_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 MAP3K3 RPS6KA6

4.90e-04160886M39482
PathwayWP_THERMOGENESIS

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KA6

5.69e-04108885M39746
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

RPS6KA1 RPS6KA2 RPS6KA3

6.17e-0427883MM14779
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA1 RPS6KA2 RPS6KA3

6.88e-0428883MM15132
PathwaySIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1

8.05e-0467884M295
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

RPS6KA1 RPS6KA2 RPS6KA3

9.31e-0431883M15195
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

RPS6KA1 RPS6KA2 RPS6KA3 MAP3K3 RPS6KA6

1.14e-03126885M16763
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING

RPS6KA1 RPS6KA2 RPS6KA3

1.45e-0336883M39908
Pubmed

The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.72e-105120437068088
Pubmed

RSK2 is a modulator of craniofacial development.

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.72e-105120424416220
Pubmed

Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.72e-105120411160957
Pubmed

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.01e-096120412832467
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF136 ZCCHC8 ZNF805 ZNF57 ZNF776 ZNF41 ZNF45 ZNF264 ZNF799

1.46e-08181120937372979
Pubmed

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.

RPS6KA1 RPS6KA3 RPS6KB1

4.01e-083120315226426
Pubmed

Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning.

RPS6KA1 RPS6KA2 RPS6KA3

4.01e-083120312393804
Pubmed

The Clinical Implications of RSK1-3 in Human Breast Cancer.

RPS6KA1 RPS6KA2 RPS6KA3

4.01e-083120326977024
Pubmed

Human rsk isoforms: cloning and characterization of tissue-specific expression.

RPS6KA1 RPS6KA2 RPS6KA3

4.01e-08312038141249
Pubmed

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.

RPS6KA1 RPS6KA2 RPS6KA3

1.60e-07412039770464
Pubmed

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

RPS6KA1 RPS6KA2 RPS6KA3

3.99e-075120310480933
Pubmed

Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.

RPS6KA1 RPS6KA2 RPS6KA3

3.99e-075120316217014
Pubmed

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.

RPS6KA1 RPS6KA2 RPS6KA3

3.99e-07512039915826
Pubmed

The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.

RPS6KA1 RPS6KA2 RPS6KA3

3.99e-075120315867353
Pubmed

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.

RPS6KA1 RPS6KA2 RPS6KA3

7.95e-07612038688081
Pubmed

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.

RPS6KA1 RPS6KA3 RPS6KB1

7.95e-076120311297520
Pubmed

NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.

RPS6KA1 RPS6KA2 RPS6KA3

7.95e-076120311175347
Pubmed

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

RPS6KA1 RPS6KA2 RPS6KA3

7.95e-076120316626623
Pubmed

Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.

RPS6KA1 RPS6KA2 RPS6KA3

7.95e-07612038939914
Pubmed

CREB is a regulatory target for the protein kinase Akt/PKB.

RPS6KA1 RPS6KA2 RPS6KA3

2.22e-06812039829964
Pubmed

Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.

RPS6KA1 RPS6KA3 RPS6KB1

3.31e-069120317512525
Pubmed

Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.

RPS6KA1 RPS6KA2 RPS6KB1

3.31e-069120321035469
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 G2E3 ZNF215 RPS6KA6 LYN TRIM37

6.13e-06372120922939624
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TTC28 MYO9A ZCCHC8 RPS6KA2 KIF1B ALS2 BCR MAP3K3 ALMS1 CRYBG3 KIF13A TNPO3 OTOG

9.19e-068611201336931259
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

FLNB DMXL2 KIF1B ZNF23 KARS1 ALMS1 CDK5RAP2 PYGM ZNF426 TRAPPC2

9.27e-064971201023414517
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

1.18e-052120211448776
Pubmed

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

RPS6KA1 RPS6KA3

1.18e-052120219716794
Pubmed

The RSK family of kinases: emerging roles in cellular signalling.

RPS6KA1 RPS6KA3

1.18e-052120218813292
Pubmed

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.

RPS6KA1 RPS6KB1

1.18e-05212029560223
Pubmed

Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism.

RPS6KA1 RPS6KA3

1.18e-052120226625210
Pubmed

Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase.

TEC LYN

1.18e-05212028621063
Pubmed

Structural and functional analysis of pp70S6k.

RPS6KA1 RPS6KB1

1.18e-05212028524831
Pubmed

Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.

TRAPPC2B TRAPPC2

1.18e-052120214597397
Pubmed

Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study.

TCN2 MTRR

1.18e-052120218226574
Pubmed

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover.

RPS6KA1 RPS6KA3

1.18e-052120217494629
Pubmed

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.

RPS6KA2 RPS6KA6

1.18e-052120223635776
Pubmed

Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells.

TEC LYN

1.18e-05212029446655
Pubmed

Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors.

RPS6KA1 RPS6KA2

1.18e-052120215112576
Pubmed

Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.

RPS6KA1 RPS6KA3

1.18e-052120225889895
Pubmed

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit.

RPS6KA2 RPS6KA3

1.18e-052120211495723
Pubmed

Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.

TRAPPC2B TRAPPC2

1.18e-052120210431248
Pubmed

The non-receptor tyrosine kinase Lyn is localised in the developing murine blood-brain barrier.

TEK LYN

1.18e-05212027589891
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4 RASA4B

1.18e-052120216041389
Pubmed

Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).

TRAPPC2B TRAPPC2

1.18e-052120212939648
Pubmed

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

RPS6KA1 RPS6KA3

1.18e-05212022779569
Pubmed

Proteome-wide analysis of phospho-regulated PDZ domain interactions.

RPS6KA1 RPS6KA2 KCNJ4 HEATR5B

1.36e-0542120430126976
Pubmed

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.

RPS6KA1 RPS6KA2 RPS6KA3

1.42e-0514120315305288
Pubmed

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

RPS6KA1 RPS6KA2 RPS6KA3

1.42e-051412039687510
Pubmed

Mutation of the 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Substrate-Docking Site in the Developing Brain Causes Microcephaly with Abnormal Brain Morphogenesis Independently of Akt, Leading to Impaired Cognition and Disruptive Behaviors.

RPS6KA2 RPS6KA3 RPS6KB1

1.77e-0515120327644329
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

RPS6KA1 RPS6KA2 RPS6KA3 GTPBP1 IBTK RPS6KA6

2.05e-05160120631678930
Pubmed

An integrated workflow for charting the human interaction proteome: insights into the PP2A system.

ZNF136 MYO9A ZCCHC8 TDRD1 S100A9

3.30e-05105120519156129
Pubmed

SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.

RPS6KA1 RPS6KA3

3.53e-053120221501342
Pubmed

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.

RPS6KA1 RPS6KA3

3.53e-053120219332537
Pubmed

p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors.

RPS6KA1 RPS6KA3

3.53e-053120236612117
Pubmed

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.

RPS6KA1 RPS6KA3

3.53e-053120219036157
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4 RASA4B

3.53e-053120225637021
Pubmed

Associations Between MTR A2756G, MTRR A66G, and TCN2 C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate: A Meta-Analysis.

TCN2 MTRR

3.53e-053120230004262
Pubmed

Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.

RPS6KA2 RPS6KA3

3.53e-053120212016217
Pubmed

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

RPS6KA1 RPS6KA3

3.53e-053120226158630
Pubmed

Molecular crosstalk between p70S6k and MAPK cell signaling pathways.

RPS6KA3 RPS6KB1

3.53e-053120212054624
Pubmed

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

RPS6KA1 RPS6KB1

3.53e-053120215905173
Pubmed

Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1.

RPS6KA1 RPS6KA2

3.53e-05312028663493
Pubmed

Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.

ZNF41 ZNF81

3.53e-05312028088786
Pubmed

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice.

RPS6KB1 MSTN

3.53e-053120219141683
Pubmed

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.

RPS6KB1 NCOA1

3.53e-053120219171678
Pubmed

Ribosomal S6 kinase and AKT phosphorylation as pharmacodynamic biomarkers in patients with myelodysplastic syndrome treated with RAD001.

RPS6KA1 RPS6KB1

3.53e-053120224332215
Pubmed

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.

RPS6KA1 RPS6KA3

3.53e-053120227063456
Pubmed

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

RPS6KA1 RPS6KB1

3.53e-053120211914378
Pubmed

CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes.

BCR LYN

3.53e-053120219541367
Pubmed

Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children.

TCN2 MTRR

3.53e-053120216820193
Pubmed

The signal-dependent coactivator CBP is a nuclear target for pp90RSK.

RPS6KA1 RPS6KA2

3.53e-05312028756728
Pubmed

Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.

RPS6KA1 RPS6KA3

3.53e-053120222031759
Pubmed

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

RPS6KA1 RPS6KA3

3.53e-053120222041125
Pubmed

Initiation of HIV Reverse Transcription.

APOBEC3F KARS1

3.53e-053120221994608
Pubmed

Elucidating protein: DNA complex by oligonucleotide DNA affinity purification.

RPS6KA3 RPS6KB1

3.53e-053120222113269
Pubmed

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.

CENPC KIF1B CTCFL

3.73e-0519120314578343
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CWF19L2 TTC28 MYO9A ZCCHC8 KIF1B FNBP1L BCR ALMS1 CRYBG3 TRIM37

3.89e-055881201038580884
Pubmed

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.

LINC00518 KIF1B IRF3 G2E3 ZNF57 ITGAE LYN KIF13A

4.05e-05364120831391242
Pubmed

Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.

TEC TEK LYN

4.37e-052012037893599
Pubmed

Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.

RPS6KA1 RPS6KA2 RPS6KA3

4.37e-0520120321421818
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF136 ZNF23 ZNF283

5.09e-052112037865130
Pubmed

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

RPS6KA1 RPS6KA2 RPS6KB1

5.88e-0522120322797923
Pubmed

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.

TCN2 RPS6KB1 MTRR

5.88e-0522120326166573
Pubmed

Agrin has a pathological role in the progression of oral cancer.

NID2 FLNB ZCCHC8 S100A9 PYGM C3

6.54e-05197120629872149
Pubmed

Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate.

TCN2 MTRR

7.05e-054120216470748
Pubmed

A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.

TRAPPC2B TRAPPC2

7.05e-054120211134351
Pubmed

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.

RPS6KA2 RPS6KA3

7.05e-05412027623830
Pubmed

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

RPS6KA1 RPS6KA3

7.05e-054120211507039
Pubmed

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

RPS6KA2 RPS6KA3

7.05e-054120221527514
Pubmed

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase.

RPS6KA1 RPS6KA2

7.05e-054120210521512
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4 RASA4B

7.05e-054120216234249
Pubmed

Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.

TEK MAP3K3

7.05e-054120237658401
Pubmed

Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells.

RPS6KA1 RPS6KB1

7.05e-054120215895362
Pubmed

Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.

RPS6KA1 RPS6KA3

7.05e-054120211432835
Pubmed

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.

RPS6KA1 RPS6KA2

7.05e-054120210949026
Pubmed

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

RASA4 RASA4B

7.05e-054120221460216
Pubmed

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.

RPS6KA1 RPS6KA3

7.05e-054120225513777
Pubmed

VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.

RPS6KA1 RPS6KB1

7.05e-054120212019261
Pubmed

Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population.

TCN2 MTRR

7.05e-054120229348398
Pubmed

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.

TCN2 MTRR

7.05e-054120218386810
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF717 ZNF136 ZNF671 ZNF805 ZNF215 ZNF57 ZNF677 CTCFL ZNF776 ZNF23 ZNF334 ZNF41 ZNF45 ZNF283 RBAK ZNF264 ZNF799 ZNF81 ZNF518B ZNF426

4.48e-11718822028
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

1.27e-07118241156
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4 RASA4B

8.93e-0410822830
GeneFamilyWD repeat domain containing

DMXL2 CHAF1B WDR76 WDFY4 WDR35 CORO7

1.22e-03262826362
GeneFamilyX-linked mental retardation|Angiotensin receptors

RPS6KA3 ZNF41 ZNF81

1.79e-0353823103
GeneFamilyLipases|Arylacetamide deacetylase family

DAGLB LIPK

4.43e-0322822464
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_MEMORY_BCELL_DAY40_UP

MYO9A ABCA13 RPS6KA2 ALS2 WDFY4 CC2D2B ZNF23 RASA4

3.80e-062001198M9324
CoexpressionNAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN

CWF19L2 ZNF136 CENPC RPS6KB1 KIF1B ZNF805 G2E3 GTPBP1 BCR DENND6A NDUFAF7 NCOA1 ZNF518B

1.35e-0568011913M41089
ToppCellMild-Lymphoid-NK-innate_T|Mild / Condition, Lineage, Cell class and cell subclass

ZNF671 MRI1 ZNF57 ZNF23 ZNF283 WDR35

4.93e-061621196bd218e41b2eadc3bba4c7ac3e34a014f6ad8b1bf
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNB TTC28 RPS6KA2 TEK BCR PLCB4

8.72e-0617911961ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCN2 OAZ2 FNBP1L TEK PLCB4 TRIM37

1.34e-051931196ce5c3ab79900aa6f394c894267340167009c6149
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCN2 OAZ2 FNBP1L TEK PLCB4 TRIM37

1.34e-051931196634fdd157cd1efeebf6ecc810bc45e138331451a
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB S100A9 LYN

1.38e-051941196f09675cd472200363c458952f00d2e41990800ee
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB S100A9 LYN

1.50e-0519711963912301018d0863144dcfac8d1fa8adc081748d7
ToppCellVE-Treg-naive_CD4|VE / Condition, Cell_class and T cell subcluster

ZNF717 CENPC ZNF57 ZNF23 RASA4

6.24e-0515611956501baf73616e702946de9fb13d267e30a68888b
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

TTC28 WDFY4 ZNF334 PLCB4 HS3ST1

9.37e-05170119559cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCellfacs-Heart-RV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENOX1 ALMS1 ZFHX4 BCO2 C3

9.37e-051701195d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 ABCA13 S100A9 C3 TRAPPC2

9.63e-05171119595e87987a2332fa646849fb0de785f1e0b8a07dd
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 ABCA13 S100A9 C3 TRAPPC2

9.63e-05171119536657e277aad75c4f157c1726c48e09b5836cf37
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

CENPC ZCCHC8 WDR35 CORO7 HEATR5B

1.04e-0417411952274648b80dd74f3c948a779bba3391095964c34
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENOX1 ALMS1 ZFHX4 BCO2 C3

1.10e-041761195c0a084f7a8645262d61971f094689e02bf15b113
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENOX1 ALMS1 ZFHX4 BCO2 C3

1.10e-041761195cccf9201f6e2da7524b911a5961d3b227edab222
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3AP1 ZNF518B LYN HS3ST1 TEC

1.13e-041771195c2b8a3a149d70f77612759dea34df9e43953c566
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENOX1 TTC28 RPS6KA2 BMP5 ZNF334

1.13e-041771195e65c0568dc5852108e9802273499bc7cf88fafab
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3AP1 ZNF518B LYN HS3ST1 TEC

1.13e-041771195384f841aa7b2d05815af7885e481f5affc55d897
ToppCellfacs-Thymus-Epithelium-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3AP1 ZNF518B LYN HS3ST1 TEC

1.13e-0417711950e9e44119653abfd270e602e5e477a15e774638f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNB FNBP1L TDRD1 WDFY4 PLCB4

1.19e-041791195124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C2orf76 WDR76 ITGAE WDFY4 CDK5RAP2

1.19e-0417911959dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLNB FNBP1L TDRD1 WDFY4 PLCB4

1.19e-041791195edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ENOX1 ZFHX4 PLCB4 CRYBG3 HS3ST1

1.19e-04179119514fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ENOX1 ZFHX4 PLCB4 CRYBG3 HS3ST1

1.29e-0418211957b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellfacs-Aorta-Heart-3m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ITGAE WDFY4 CYRIB CORO7

1.29e-041821195df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCellfacs-Aorta-Heart-3m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA1 ITGAE WDFY4 CYRIB CORO7

1.32e-041831195062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

TTC28 TEK ZFHX4 ZNF518B CRYBG3

1.36e-04184119567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

FLNB FNBP1L TEK BCR PLCB4

1.39e-041851195f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 FNBP1L TEK PLCB4 TRIM37

1.43e-0418611950ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB TCN2 TEK PLCB4 HS3ST1

1.43e-04186119592092f11ecce22c14f244e42c499af0822977e6f
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PIK3AP1 KIF1B ZNF677 DENND6A CDK5RAP2

1.46e-041871195c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

TTC28 ABCA13 RPS6KA2 MTRR C3

1.50e-041881195ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB BCR RASA4 HS3ST1 TRIM37

1.54e-041891195d9c2adbbe3e40eb8d57200b6411533e6685ea0d2
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB BCR RASA4 HS3ST1 TRIM37

1.54e-041891195476226787c8ea0c9834a6f4c99ac7091cc20a455
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTC28 RPS6KA2 TEK PLCB4 CRYBG3

1.54e-0418911956463890d8dbee4bc198f91628a5f784970de786a
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB BCR RASA4 HS3ST1 TRIM37

1.54e-0418911953fe69bad6427e41b8d2dae450828cc21e9c3b3ad
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

TTC28 TCN2 S100A9 RPS6KA6 HS3ST1

1.58e-041901195e59e3ad044af7b4409d5ecbd326fe83862e5fc9a
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TCN2 RPS6KA2 TEK RASA4 RASA4B

1.58e-041901195141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.62e-04191119547a2afc4102199b4bc76bd01b2967c8016186462
ToppCell3'-Child09-12-SmallIntestine-Neuronal-Glial_mature|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MSTN LGI4 ZFHX4 LRRTM4 CAB39L

1.65e-041921195ac507fd7cf3b3e521a15ef03bb4e81eb23807985
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.65e-041921195ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.65e-04192119585d4d0df701451daf95e94a87a0096da1e86533b
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

RPS6KA2 RPS6KA3 SUSD2 C3 LYN

1.65e-041921195356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell3'-Child09-12-SmallIntestine-Neuronal|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MSTN LGI4 ZFHX4 LRRTM4 CAB39L

1.65e-04192119524f40dadec04f4f99c31000fa9f09d07148fa190
ToppCell3'-Child09-12-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MSTN LGI4 ZFHX4 LRRTM4 CAB39L

1.65e-04192119571e04e197825856c6d4278fc76c58ab17ffa2387
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.70e-0419311952218833749576ba1a0fc95bd155c781e7e1163c6
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.70e-0419311951b6317b740cad2439f08b9e9895426d861e7a161
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 ZBBX BCO2 CFAP70 CCDC33

1.70e-041931195ea345d34440b25f65358a53dc72831998d1c3620
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.70e-041931195f5861cfa4401b476229a7c61cd64abad79a4bbfc
ToppCelldroplet-Lung-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.70e-04193119595c9c63bddfed1a84393ccd3578cfe65bc0c1c05
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FLNB TEK PLCB4 CTPS1 HS3ST1

1.70e-0419311955f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 TMEM63C PLCB4 HS3ST1 CCDC33

1.74e-041941195e0228f593c3493175962a4817500d4337ddc4e88
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAGLB RPS6KA1 CYRIB S100A9 LYN

1.74e-0419411952224c7c943cfd5c1a329dfcf19d6e5ef8c49d85d
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAGLB RPS6KA1 CYRIB S100A9 LYN

1.74e-04194119550c5fc349533281a426bc7227a8ea9eca8d11985
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.74e-041941195e30a3765feae5cd10ddba16a166c31eb5717edd3
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

PIK3AP1 DMXL2 WDFY4 LYN TEC

1.74e-041941195c1805572bcc11b1cd29083329d7b5911489fb758
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 FNBP1L TEK HS3ST1 TRIM37

1.74e-041941195df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

ZNF717 SPG11 SUSD2 KIF13A TRIM37

1.74e-04194119588db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCellfacs-Brain_Myeloid-Cortex-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAGLB RPS6KA1 CYRIB S100A9 LYN

1.74e-0419411951662b110f84584e75150df0ac970e7df82f26e7e
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

ZNF717 SPG11 SUSD2 KIF13A TRIM37

1.74e-041941195a71728202493d4858342ea2756ea281cd0d99a3a
ToppCellMonocytes-HP_01|World / lung cells shred on cell class, cell subclass, sample id

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.74e-041941195fa6a2794baa6be6298f415330ff51b26a5402571
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAGLB RPS6KA1 CYRIB S100A9 LYN

1.74e-041941195b31d6361fa939a92a4a3dc63c209ecd3eb514e6a
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF136 TCN2 BCR DENND6A RASA4

1.78e-0419511956a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

PIK3AP1 DMXL2 WDFY4 CYRIB TEC

1.78e-041951195c172c5599379c29123340621a36bfb1fc90c2115
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.78e-041951195148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

PIK3AP1 DMXL2 WDFY4 LYN TEC

1.78e-0419511955e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 ZBBX BCO2 ATP6V0A4 CFAP70

1.78e-04195119579dc031258579ea328181dda33710dd897f1064a
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGI4 ZFHX4 LRRTM4 CAB39L DEPDC7

1.82e-041961195a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.82e-041961195a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

PIK3AP1 DMXL2 CYRIB MAP3K3 LYN

1.82e-041961195cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.82e-0419611951b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.82e-0419611957026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PIK3AP1 RPS6KA1 CYRIB C3 LYN

1.82e-041961195e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCellFetal_29-31_weeks-Immune-monocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.86e-04197119548a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.86e-041971195e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellBronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGI4 ZFHX4 LRRTM4 CAB39L DEPDC7

1.86e-0419711954a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCellChildren_(3_yrs)-Immune|Children_(3_yrs) / Lineage, Cell type, age group and donor

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.86e-041971195f18807124b91310fcd84238484a80ecdba684679
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.86e-0419711953896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellFetal_29-31_weeks-Immune-monocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DMXL2 CYRIB MAP3K3 S100A9 LYN

1.86e-0419711958b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Monocytes,_Macrophages|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-0419811957490b30462d03b5edee3bcacdef9483dd15821b5
ToppCellLPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_only / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-0419811952985c80e656e483866c696fa08c38af90311cd66
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-0419811954f86ff6ba8cbe987e7541fca4f3ae8d0e434677d
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Monocytes,_Macrophages|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-041981195c3949970cfe0cb928293ad6627aeed3ed2741b95
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-04198119557cfc1cc8b332a88e7cac7f6f042b3ffd498a1b9
ToppCellImmune|World / Lineage, Cell type, age group and donor

PIK3AP1 DMXL2 WDFY4 CYRIB LYN

1.91e-04198119565681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCellLPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages|LPS_only / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-0419811955d48539999d7a17f4165f612bf68be26c085e501
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-04198119539e52fcd467b8041da977cfe25764df02a87990a
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Monocytes,_Macrophages|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-041981195b32ca1b5d88b13a39f2cd4e129ea031f97475d29
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-0419811959aee419c59105d8a7ad83bc484b92d30a640666b
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.91e-041981195c4a004f211f72f28aacbb512c6e075cbd049be53
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

PIK3AP1 DMXL2 CYRIB MAP3K3 LYN

1.91e-041981195d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellLPS_IL1RA-Hematopoietic_Myeloid|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PIK3AP1 DMXL2 CYRIB S100A9 LYN

1.95e-0419911950e696f13c9bd135fbb31368d6dca29897d6a1a25
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FNBP1L S100A9 ATP6V0A4 CYP4X1 LYN

1.95e-041991195527aae1d9d37a50deefc01fc0c064a53673681bd
ToppCell(04)_Interm._basal>secr.|World / shred by cell type by condition

S100A9 CYP4X1 C3 LYN HS3ST1

1.95e-041991195ed399244433f781fc291a9bff16825b8a3ca294f
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Vein|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB TEK BCR RASA4 PLCB4

1.95e-041991195cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO9A RPS6KA2 SUSD2 TMEM245 C3

1.95e-0419911952dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNB TTC28 TEK BCR PLCB4

1.95e-0419911956a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MGAT4D ABCA13 FAT2 PER2 HS3ST1

1.95e-041991195f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PIK3AP1 TCN2 OAZ2 S100A9 LYN

1.95e-041991195df946601b295be5419c09befbfa73f4314eef116
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB TEK BCR RASA4 PLCB4

2.00e-0420011957eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB TEK BCR RASA4 PLCB4

2.00e-042001195b036f5e22c95a3b14391785b6e91aa183b9bc9a8
DrugBI D1870

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.13e-07111174ctd:C516541
DrugOvta

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.37e-07141174CID003081047
DrugAD 288

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

6.37e-07141174CID000073553
DrugR165481

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

1.15e-06161174CID005459348
DrugNorethindrone [68-22-4]; Down 200; 13.4uM; HL60; HT_HG-U133A

MYO9A RPS6KA2 KIF1B ZNF215 NCOA1 C3 PLCB4 ZNF426

8.00e-0619611782383_DN
DrugAC1MS9WM

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

1.06e-05271174CID003530978
DrugK00085

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

1.06e-05271174CID009549283
DrugA61603

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.42e-05331174CID004038180
Drug1-iodobutane

C3 TRIM37

2.62e-0521172CID000010962
DrugCymal-6

RPS6KA1 RPS6KA2 RPS6KA6

3.64e-05131173CID000447688
DiseaseCoffin-Lowry syndrome (implicated_via_orthology)

RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

2.11e-1041144DOID:3783 (implicated_via_orthology)
DiseaseX-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)

TRAPPC2B TRAPPC2

1.48e-0521142DOID:0080362 (implicated_via_orthology)
DiseaseJuvenile amyotrophic lateral sclerosis

ALS2 SPG11

4.43e-0531142cv:C3468114
DiseaseJuvenile amyotrophic lateral sclerosis

ALS2 SPG11

8.83e-0541142C3468114
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

8.83e-0541142EFO_0020830
Diseaseobesity (implicated_via_orthology)

BMP5 ALMS1 ZFHX4 NCOA1 C3 CORO7

1.93e-042151146DOID:9970 (implicated_via_orthology)
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

TRAPPC2B TRAPPC2

2.20e-0461142DOID:14789 (implicated_via_orthology)
DiseaseMental Retardation, X-Linked 1

RPS6KA3 ZNF41 ZNF81

2.57e-04321143C2931498
Diseasecholestasis (implicated_via_orthology)

ABCB11 PYGM

5.23e-0491142DOID:13580 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

KIF1B C3

1.12e-03131142DOID:332 (biomarker_via_orthology)
Diseaselymphocyte count

DAGLB PIK3AP1 FLNB TTC28 RPS6KA1 KIF1B TDRD1 BCR OR10X1 CYRIB CC2D2B ALMS1 C3 CORO7

1.55e-03146411414EFO_0004587
Diseaseisocitrate measurement

LRRTM4 HS3ST1

1.71e-03161142EFO_0010505
DiseaseAmyotrophic lateral sclerosis

ALS2 SPG11

1.94e-03171142cv:C0002736
Diseasecystathionine measurement

TEC TEC

2.42e-03191142EFO_0010474
Diseaseurinary metabolite measurement

RPS6KA2 RPS6KB1 BMP5 ALMS1 CCDC33

2.67e-032451145EFO_0005116
DiseaseArthrogryposis

MYO9A LGI4

2.96e-03211142C0003886
Diseaselateral orbital frontal cortex volume measurement

KIF1B OTOG

3.86e-03241142EFO_0010312

Protein segments in the cluster

PeptideGeneStartEntry
EILPNGHVKVHFVDY

TDRD1

786

Q9BXT4
GHVKVHFVDYGNIEE

TDRD1

791

Q9BXT4
FEAFHVFKVFVASPH

CAB39L

271

Q9H9S4
PVQAKFEFHHGDYEK

C6orf62

141

Q9GZU0
AHFRKYHDANFIPTV

CTCFL

531

Q8NI51
VFHPYHFELVKPTES

CCDC33

336

Q8N5R6
EVTPFQEHFGIYTGK

CRYBG3

1121

Q68DQ2
VIIYEKPHFHGQAKE

CRYBG3

2481

Q68DQ2
EFIPQHVGAFSVEKY

ALS2

1351

Q96Q42
FYVNVEFHHERGLVK

BCR

176

P11274
HFRFIKTPEYLHIDQ

GTPBP1

541

O00178
HSHREKPGIFYQQEF

ALMS1

716

Q8TCU4
HNKEPVYSLDFQHGT

CHAF1B

11

Q13112
EVKAAVYHHFISDGV

C3

911

P01024
QHVFEYLPEFLHTFK

ABCA13

3201

Q86UQ4
IKGEIEFHNVTFHYP

ABCB11

416

O95342
THFKFEETKTHGPYV

LINC00518

66

Q8N0U6
HVFQEDFIIGYKPHK

DMXL2

851

Q8TDJ6
YKQPIHHNGFVSKEF

DMXL2

1086

Q8TDJ6
QFYKCHPDIFIEHFG

DEPDC7

496

Q96QD5
HSQHLPAKVEFGVYE

PIK3AP1

681

Q6ZUJ8
KFIAVNGATAHPHYD

BCO2

216

Q9BYV7
FEHRNFKPVVYHGVN

C2orf76

16

Q3KRA6
VHPFVEVSFQHTVYK

CC2D2B

916

Q6DHV5
EFHGPTEHIYKTNIE

CDK5RAP2

91

Q96SN8
EYQVHLPPTFHAVAF

RASA4

56

O43374
EYQVHLPPTFHAVAF

RASA4B

56

C9J798
HRFEPVVFEEKSHYK

KCNJ4

316

P48050
LHYSVPEEAKHGNFV

PCDHA7

31

Q9UN72
VNDGKPHIVHFQYEV

OAZ2

71

O95190
KEFILVGFSVYPHVQ

OR10X1

26

Q8NGY0
IHFGFASIVYLKPEA

OR10X1

266

Q8NGY0
PGAEQEYEHVSFHKI

LRRTM4

411

Q86VH4
PAHKYILAVHSDFFQ

IBTK

576

Q9P2D0
TKPIVFEVFGHYQQH

KIF1B

1186

O60333
NHPFIVKLHYAFQTE

RPS6KA3

126

P51812
FHPGKLHFVFNIVEF

MTRR

461

Q9UBK8
IGYHVPRKAVEFHED

CORO7

341

P57737
LIIKHFHEAYPGSVV

TMEM63C

236

Q9P1W3
FLLVAAPFYHVHGEE

ITGAE

531

P38570
DKYAVRFIPHENGVH

FLNB

2341

O75369
KFVEFLAPHDVGVFH

PER2

226

O15055
YTGKVHEDVFPGHFI

FAT2

3016

Q9NYQ8
EDQHKFPHYFGKEII

CWF19L2

836

Q2TBE0
KHPFIVDLIYAFQTG

RPS6KB1

151

P23443
NHPFIVKLHYAFQTE

RPS6KA6

131

Q9UK32
QHVGIHSSFPRKEQY

MGAT4D

356

A6NG13
PVHFTDVDLHAYIVG

NID2

546

Q14112
YHVIQRVHTPFESFK

G2E3

546

Q7L622
AKIFRGQVYSQPEHH

APOBEC3F

51

Q8IUX4
ALFGVVFPHVSYKHR

HEATR5B

786

Q9P2D3
FNGEQHKHFYVVIPQ

FNBP1L

196

Q5T0N5
VRPQDTYQFFVKHGE

CENPC

841

Q03188
HVSFHDKVYELPFLV

DAGLB

346

Q8NCG7
FHVYPYLDSVVHEKT

CFAP70

361

Q5T0N1
TPGFHFNILKAYIEV

CYP4X1

141

Q8N118
YIHFFHTVLKQIAPE

DENND6A

181

Q8IWF6
HYKEFRFDLTQIPHG

BMP5

176

P22003
DFDPVHGDVIKHYKI

LYN

171

P07948
IILYDHVHPVGAFAK

CYRIB

261

Q9NUQ9
PGHEYHFRVVAKNEL

IGFN1

1106

Q86VF2
TFLHVHPFGANIEYL

ENOX1

576

Q8TC92
HKVTTVFGQPLDLHY

MAP3K3

71

Q99759
VGFFTLVHFPQEHIT

OTOG

1076

Q6ZRI0
HDPHKIYEFVNSGVG

IRF3

101

Q14653
HEYFHEPNKKFFELV

HS3ST1

286

O14792
EHGSQFFYLPIIKHS

KIF13A

1206

Q9H1H9
FLVHNFLYQPKHDPT

SUSD2

646

Q9UGT4
GHTFKPLAEIYEQHV

TRIM37

126

O94972
INTFHQYSVKLGHPD

S100A9

16

P06702
YAQPVKFQGFHVAEE

PLCB4

571

Q15147
YVAHPVEKRFVHEAE

SAXO1

211

Q8IYX7
TDFIQKYSHLQPGDH

KARS1

106

Q15046
EKHAFGSIPEIIEYH

TEC

316

P42680
KELIHFEVSIGHYGN

FER1L5

521

A0AVI2
FKGPTQIYQHHEIDL

LGI4

521

Q8N135
FYLAHEFFDVLPVHK

NDUFAF7

211

Q7L592
HQEDPITYKGFVHKV

MOV10

406

Q9HCE1
VYSILHVGDHAEFVK

NCOA1

156

Q15788
GECEFVFLQKYPHTH

MSTN

311

O14793
DHPFFVGVQYHPEFL

CTPS1

516

P17812
AIVAKHHGIPFYVAA

MRI1

266

Q9BV20
FTTLKPHVGIVHYEG

MTG2

256

Q9H4K7
PFEVDGLLFYHKQTH

SNUPN

251

O95149
VDKLLYAVEPFHQGH

TCN2

176

P20062
DFVHQVEKLYLGHFQ

SPG11

791

Q96JI7
EHVHGQFFPYAALEK

ZFHX4

1921

Q86UP3
PKYHQVFSHIVSLEG

ZCCHC8

201

Q6NZY4
YDLFKHQTVHTGERP

ZNF671

326

Q8TAW3
FQIHERTHTGEKPYE

ZNF136

351

P52737
SFVEHQRTHTGEKPY

ZNF334

586

Q9HCZ1
EFTLPVHFYGHVEHT

PYGM

196

P11217
FIIHQRAHTGEKPYE

RBAK

276

Q9NYW8
ITYPQLEGFKFHHEA

WDFY4

361

Q6ZS81
AFVYPSVFQRHEKTH

ZNF799

401

Q96GE5
YKNGSFIHSVPRHEV

TEK

156

Q02763
PHGTHVYFQDINVIF

nan

21

Q6ZUG5
YFVIVGHHDNPVFEM

TRAPPC2

6

P0DI81
IRDSAHQYFIHDKPF

ZNF677

151

Q86XU0
EHLYKTNDEVIHGIF

TNPO3

351

Q9Y5L0
FLTVHQRTHAGEKPY

ZNF717

521

Q9BY31
LIHHYVIHTGEKPFE

ZNF264

386

O43296
FGDVFVHQAIHTIEY

ATP6V0A4

716

Q9HBG4
VIHFGVVDFLEKRYH

TMEM245

391

Q9H330
GIVKFHEHYLGENTV

TTC28

1256

Q96AY4
FNTHQRIHTGEKPYE

ZNF41

496

P51814
QQPKEDGVYVFHPHS

WDR76

346

Q9H967
FRHFQYLKVSGPHEA

ZNF215

51

Q9UL58
YPQAFQRHEKTHTGE

ZNF57

291

Q68EA5
NYIVHQRIHTGEKPF

ZNF23

546

P17027
KDVNIVQFYTPFGEH

WDR35

281

Q9P2L0
YFVIVGHHDNPVFEM

TRAPPC2B

6

P0DI82
FNIHFRVHTGEKPYK

ZNF45

431

Q02386
FQIHERTHTGEKPYE

ZNF426

491

Q9BUY5
LIHHYVIHTGEKPFE

ZNF805

386

Q5CZA5
FPYENGIHQHHVFDK

ZBBX

436

A8MT70
FNKHQTIHTGEKPYV

ZNF81

541

P51508
QLTRHQVFHTGEKPY

ZNF283

501

Q8N7M2
EFQRHLVKHTGIFPY

ZNF518B

176

Q9C0D4
HEPFIFHEVGKDFLS

ZNF776

161

Q68DI1
HPFVVKLHYAFQTEG

RPS6KA1

121

Q15418
VNHPFIVKLHYAFQT

RPS6KA2

116

Q15349
FHPHTLFDQFIATKV

LIPK

231

Q5VXJ0
EHNGHIFKATQYSIP

MYO9A

1996

B2RTY4