Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	excitatory synapse	LRRC4 PICALM ADCY8 SLC6A9 MET PALLD	4.47e-05	107	125	6	GO:0060076
Domain	Leu-rich_rpt	CARMIL1 PIDD1 NLRP1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LRRC25 RNH1 LGI2 PKD1 PRAME TPBG GP5	8.46e-19	271	114	22	IPR001611
Domain	-	CARMIL1 PIDD1 NLRP1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LRRC25 RNH1 LGI2 PKD1 PRAME TPBG GP5	3.18e-17	321	114	22	3.80.10.10
Domain	L_dom-like	CARMIL1 PIDD1 NLRP1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LRRC25 RNH1 LGI2 PKD1 PRAME TPBG GP5	5.02e-17	328	114	22	IPR032675
Domain	LRR_1	PIDD1 NLRP1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS RNH1 LGI2 PRAME TPBG GP5	7.11e-17	219	114	19	PF00560
Domain	LRR_8	PIDD1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LGI2 PKD1 TPBG GP5	3.44e-16	171	114	17	PF13855
Domain	LRR_TYP	PIDD1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LGI2 PKD1 TPBG GP5	6.17e-16	177	114	17	SM00369
Domain	Leu-rich_rpt_typical-subtyp	PIDD1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS LGI2 PKD1 TPBG GP5	6.17e-16	177	114	17	IPR003591
Domain	LRR	PIDD1 NLRP1 LRRIQ4 NRROS LRRC58 LRRC4 LGI4 LRRC8D TLR8 CNOT6 TSKU TRIL SLIT2 IGFALS PKD1 TPBG GP5	5.24e-15	201	114	17	PS51450
Domain	Cys-rich_flank_reg_C	LRRC4 LGI4 TLR8 TRIL SLIT2 IGFALS LGI2 PKD1 TPBG GP5	1.83e-10	90	114	10	IPR000483
Domain	LRRCT	LRRC4 LGI4 TLR8 TRIL SLIT2 IGFALS LGI2 PKD1 TPBG GP5	1.83e-10	90	114	10	SM00082
Domain	DUF1220	NBPF3 NBPF11 NBPF1 NBPF9 NBPF14	3.48e-09	11	114	5	PF06758
Domain	NBPF_dom	NBPF3 NBPF11 NBPF1 NBPF9 NBPF14	3.48e-09	11	114	5	IPR010630
Domain	NBPF	NBPF3 NBPF11 NBPF1 NBPF9 NBPF14	3.48e-09	11	114	5	PS51316
Domain	LRRNT	LRRC4 TSKU TRIL SLIT2 IGFALS PKD1 TPBG GP5	1.50e-07	98	114	8	IPR000372
Domain	LRRNT	LRRC4 TSKU TRIL SLIT2 IGFALS PKD1 TPBG GP5	1.50e-07	98	114	8	SM00013
Domain	DUF1220	NBPF3 NBPF11 NBPF1 NBPF9	1.62e-07	9	114	4	SM01148
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	6.28e-07	12	114	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	6.28e-07	12	114	4	IPR027970
Domain	LRRCT	LGI4 TRIL SLIT2 TPBG GP5	1.37e-06	32	114	5	PF01463
Domain	LRRNT	LRRC4 SLIT2 IGFALS PKD1 TPBG	1.76e-05	53	114	5	PF01462
Domain	SAPS	PPP6R1 PPP6R2	1.10e-04	3	114	2	IPR007587
Domain	SAPS	PPP6R1 PPP6R2	1.10e-04	3	114	2	PF04499
Domain	LRR_6	CARMIL1 NLRP1 NRROS RNH1	3.53e-04	55	114	4	PF13516
Domain	EPTP	LGI4 LGI2	5.45e-04	6	114	2	PF03736
Domain	EPTP	LGI4 LGI2	5.45e-04	6	114	2	IPR005492
Domain	EAR	LGI4 LGI2	7.60e-04	7	114	2	IPR009039
Domain	EAR	LGI4 LGI2	7.60e-04	7	114	2	PS50912
Domain	ARM-type_fold	SMG1 CAND1 RTTN PPP6R1 HUWE1 NOM1 PPP6R2 KPNA1	1.13e-03	339	114	8	IPR016024
Domain	ZU5	PIDD1 TJP1	1.61e-03	10	114	2	PS51145
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF3 NBPF8 NBPF12 NBPF11 NBPF1 NBPF9 NBPF14	8.16e-13	21	127	7	16079250
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	3.59e-12	6	127	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	3.59e-12	6	127	5	25930072
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF8 NCOA6 NBPF12 PPM1D RTTN HUWE1 NBPF11 NBPF1 SLIT2 NBPF9 NBPF14	3.74e-11	170	127	11	23314748
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF12 NBPF1 NBPF9 NBPF14	1.49e-10	10	127	5	22973535
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATMIN HIF1A CAND1 ATXN7L1 CARMIL1 RALGAPB TTC14 HUWE1 OGDH LRRC8D SH2B1 NBPF1 RLF GPR158 TJP1 TOX3 TRMT13 ANKRD24 XYLB QSER1 CSMD1 UTRN KPNA1 RAVER1	8.47e-10	1489	127	24	28611215
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.41e-08	24	127	5	32212159
Pubmed	Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia.	SMG1 HIF1A	1.32e-05	2	127	2	19406746
Pubmed	Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.	NBPF11 NBPF1	1.32e-05	2	127	2	7700633
Pubmed	Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans.	HIF1A NR4A1	1.32e-05	2	127	2	30111591
Pubmed	Biochemical and immunomorphological evaluation of hepatocyte growth factor and c-Met pathway in patients with critical limb ischemia.	HIF1A MET	1.32e-05	2	127	2	24947080
Pubmed	Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteins.	TLR8 TJP1	1.32e-05	2	127	2	34673372
Pubmed	Three conformational states of the p300 CH1 domain define its functional properties.	HIF1A SUCO	1.32e-05	2	127	2	12924942
Pubmed	Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer.	HIF1A SLIT2	1.32e-05	2	127	2	26935705
Pubmed	Chronic hypoxia of endothelial cells boosts HIF-1α-NLRP1 circuit in Alzheimer's disease.	HIF1A NLRP1	1.32e-05	2	127	2	37245530
Pubmed	The expression of epidermal growth factor-like domain 7 regulated by oxygen tension via hypoxia inducible factor (HIF)-1α activity.	HIF1A EGFL7	1.32e-05	2	127	2	25539718
Pubmed	Hepatitis C virus infection protein network.	RNF31 NR4A1 SLIT2 KPNA1	1.70e-05	42	127	4	18985028
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SMG1 NCOA6 RALGAPB MED13L GPR158 TRIM9 PCNX1	2.00e-05	225	127	7	12168954
Pubmed	Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells.	HIF1A MET	3.96e-05	3	127	2	20154724
Pubmed	Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.	HIF1A MET	3.96e-05	3	127	2	29717265
Pubmed	WIP1 is a novel specific target for growth hormone action.	PPM1D GHR	3.96e-05	3	127	2	37876819
Pubmed	The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response.	HIF1A TLR8	3.96e-05	3	127	2	19381167
Pubmed	Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.	GHR IGFALS	3.96e-05	3	127	2	20928887
Pubmed	SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.	NLRP1 KPNA1	3.96e-05	3	127	2	19001869
Pubmed	Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature.	GHR IGFALS	3.96e-05	3	127	2	31834863
Pubmed	Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.	HIF1A NR4A1	3.96e-05	3	127	2	14729605
Pubmed	Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1.	ATMIN HIF1A	3.96e-05	3	127	2	26875667
Pubmed	The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.	LGI4 LGI2	3.96e-05	3	127	2	12023020
Pubmed	Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.	HIF1A OGDH	3.96e-05	3	127	2	27923773
Pubmed	HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse.	HIF1A TJP1	3.96e-05	3	127	2	17784876
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	MYH9 RNF31 HUWE1 OGDH KLHDC10 PALLD	5.79e-05	182	127	6	31067453
Pubmed	Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.	LGI4 KCNA1 LGI2	6.03e-05	21	127	3	25707359
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TTC14 BPIFB1 NRROS LRRC4 LGI4 SNAP47 LRRC8D TLR8 TSKU LRRC25 EGFL7 CSMD1 ITIH6	6.77e-05	985	127	13	12975309
Pubmed	Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.	HIF1A NR4A1	7.90e-05	4	127	2	15385570
Pubmed	Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α.	HIF1A MET	7.90e-05	4	127	2	30056064
Pubmed	Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells.	HIF1A MET	7.90e-05	4	127	2	36182093
Pubmed	Identification of Murr1 as a regulator of the human delta epithelial sodium channel.	COMMD1 SCNN1B	7.90e-05	4	127	2	14645214
Pubmed	The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation.	HIF1A TLR8	7.90e-05	4	127	2	19841637
Pubmed	COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.	HIF1A COMMD1	7.90e-05	4	127	2	19802386
Pubmed	Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.	PPP6R1 PPP6R2	7.90e-05	4	127	2	19621075
Pubmed	Decorin inhibits angiogenic potential of choroid-retinal endothelial cells by downregulating hypoxia-induced Met, Rac1, HIF-1α and VEGF expression in cocultured retinal pigment epithelial cells.	HIF1A MET	7.90e-05	4	127	2	24016866
Pubmed	COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.	HIF1A COMMD1	7.90e-05	4	127	2	20458141
Pubmed	SEPT9_i1 is required for the association between HIF-1α and importin-α to promote efficient nuclear translocation.	HIF1A KPNA1	7.90e-05	4	127	2	24067372
Pubmed	Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.	HIF1A KPNA1	7.90e-05	4	127	2	22367210
Pubmed	Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain.	LGI4 LGI2	7.90e-05	4	127	2	19833108
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF8 ALLC MYH9 NBPF12 NLRP1 NBPF11 NBPF1 NBPF9 NBPF14	1.17e-04	513	127	9	25798074
Pubmed	Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation.	HIF1A NR4A1	1.31e-04	5	127	2	18305400
Pubmed	Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.	HIF1A MET	1.31e-04	5	127	2	22194599
Pubmed	Morphogenesis and Compartmentalization of the Intestinal Crypt.	MYH9 TJP1	1.31e-04	5	127	2	29689194
Pubmed	Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.	NBPF11 NBPF1	1.31e-04	5	127	2	20096688
Pubmed	Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients.	MYH9 GP5	1.31e-04	5	127	2	15477207
Pubmed	Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.	FNIP2 PKD1	1.31e-04	5	127	2	36794754
Pubmed	COMMD1 downregulates the epithelial sodium channel through Nedd4-2.	COMMD1 SCNN1B	1.31e-04	5	127	2	20237237
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 RNF31 RALGAPB PPP6R1 NOM1 QSER1 CLSPN PPP6R2 PALLD RAVER1	1.43e-04	650	127	10	38777146
Pubmed	Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.	HIF1A COMMD1	1.97e-04	6	127	2	17371845
Pubmed	Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.	MET PKD1	1.97e-04	6	127	2	20852388
Pubmed	Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.	HIF1A MET	1.97e-04	6	127	2	23928995
Pubmed	Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.	ATXN7L1 PCNX1	1.97e-04	6	127	2	22881374
Pubmed	Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.	HIF1A MET	1.97e-04	6	127	2	25187556
Pubmed	A common protein interaction domain links two recently identified epilepsy genes.	LGI4 LGI2	1.97e-04	6	127	2	12095917
Pubmed	Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.	PPP6R1 PPP6R2	1.97e-04	6	127	2	20065038
Pubmed	The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.	LGI4 LGI2	1.97e-04	6	127	2	12217514
Pubmed	Secondary Placental Defects in Cxadr Mutant Mice.	HIF1A MET EGFL7	2.18e-04	32	127	3	31338035
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NR2C1 CAND1 HUWE1 MED13L IDS LRRC4 SH2B1 COMMD1 TRIM9 TJP1 PKD1 ANKRD24 UTRN KPNA1	2.62e-04	1285	127	14	35914814
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	HUWE1 RNH1 PPP6R2 KPNA1	2.73e-04	85	127	4	19596235
Pubmed	Sall1 plays pivotal roles for lens fiber cell differentiation in mouse.	SALL1 TJP1	2.75e-04	7	127	2	30929925
Pubmed	The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.	LGI4 LGI2	2.75e-04	7	127	2	16341215
Pubmed	Identification of novel cadherins expressed in human melanoma cells.	PCDHB14 PCDHB11	2.75e-04	7	127	2	9182820
Pubmed	Functional proteomics mapping of a human signaling pathway.	SMG1 NCOA6 HUWE1 RLF TSKU NOM1 PKD1 UTRN KPNA1	3.34e-04	591	127	9	15231748
Pubmed	Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway.	HIF1A KPNA1	3.65e-04	8	127	2	18187047
Pubmed	Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.	PPP6R1 PPP6R2	3.65e-04	8	127	2	16769727
Pubmed	Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice.	MYH9 SALL1	3.65e-04	8	127	2	30886905
Pubmed	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.	HIF1A HUWE1	3.65e-04	8	127	2	27934968
Pubmed	Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.	PPP6R1 PPP6R2	3.65e-04	8	127	2	18186651
Pubmed	Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.	GHR IGFALS	3.65e-04	8	127	2	17546465
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CAND1 RNF31 HUWE1 LRRC58 TJP1 PRAME	4.34e-04	264	127	6	32814769
Pubmed	Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.	HIF1A MET	4.68e-04	9	127	2	26517842
Pubmed	Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.	PPP6R1 PPP6R2	4.68e-04	9	127	2	21187329
Pubmed	Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway.	DRGX SLIT2	4.68e-04	9	127	2	22806432
Pubmed	Substrate-mediated regulation of cullin neddylation.	HIF1A CAND1	4.68e-04	9	127	2	17439941
Pubmed	Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System.	SALL1 TJP1	4.68e-04	9	127	2	29768210
Pubmed	FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.	PPP6R1 LRRC4 OR6B3	4.92e-04	42	127	3	29348145
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	CAND1 GPR85 HUWE1 LRRC58 OGDH PICALM	4.98e-04	271	127	6	25737280
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	HIF1A RNF31 CARMIL1 AMDHD2 PIDD1 NBPF11 IDS PICALM SLC6A9 TJP1 PKD1 ANKRD24 UTRN	5.19e-04	1215	127	13	15146197
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NBPF12 ATXN7L1 RALGAPB CNOT6	5.67e-04	103	127	4	10574462
Pubmed	In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.	SALL1 TJP1	5.84e-04	10	127	2	21345181
Pubmed	ZMYND10 functions in a chaperone relay during axonemal dynein assembly.	ZMYND10 DNAH17	5.84e-04	10	127	2	29916806
Pubmed	mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.	CNOT6 GHR	5.84e-04	10	127	2	27618784
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	HIF1A MED13L	5.84e-04	10	127	2	23746844
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FNIP2 MYH9 CARMIL1 RALGAPB BPIFB1 OGDH SNAP47 LRRC8D CNOT6 NOM1 DNAH17 CORO6 CSMD1	6.36e-04	1242	127	13	30973865
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NR2C1 MYH9 CAND1 CARMIL1 PPP6R1 PICALM TRIM9 TJP1 PPP6R2 UTRN PALLD	6.50e-04	934	127	11	33916271
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	HUWE1 KPNA1	7.12e-04	11	127	2	11809816
Pubmed	Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis.	MET TJP1	7.12e-04	11	127	2	26839363
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	CARMIL1 RALGAPB PANX2 LRRC4 SLC6A9 KCNA1 GPR158	7.44e-04	405	127	7	38187761
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 ATMIN RALGAPB PPP6R1 MED13L TRIL LGI2	7.66e-04	407	127	7	12693553
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	NCOA6 PICALM KPNA1	8.22e-04	50	127	3	37974198
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MYH9 CAND1 PPP6R1 HUWE1 PICALM KCNA1 GPR158 TJP1 QSER1 PPP6R2 KPNA1	8.34e-04	963	127	11	28671696
Pubmed	Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.	PPP6R1 PPP6R2	8.52e-04	12	127	2	35512830
Pubmed	A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.	TRIL FAM153B	8.52e-04	12	127	2	9776767
Pubmed	Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.	HIF1A OGDH	8.52e-04	12	127	2	25438054
Cytoband	1q21.1	NBPF8 NBPF11 NBPF9 NBPF14	2.75e-05	62	127	4	1q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	2.10e-04	8	127	2	chr9q12
GeneFamily	Neuroblastoma breakpoint family	NBPF3 NBPF8 NBPF12 NBPF26 NBPF11 NBPF1 NBPF9 NBPF14	2.78e-14	23	75	8	662
GeneFamily	Protein phosphatase 6 regulatory subunits	PPP6R1 PPP6R2	2.52e-04	6	75	2	699
Coexpression	LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES	MYH9 NR4A1 MED13L INPP4B TJP1 UTRN PALLD	9.32e-06	155	124	7	M39246
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	NR2C1 NCOA6 NBPF12 PCDHB14 PCDHB11 TTC14 PIDD1 NBPF26 NLRP1 NR4A1 MED13L NBPF11 IDS LRRC4 SH2B1 NBPF1 TOX3 PKD1 PPP6R2 SUCO NBPF14 PALLD TPBG	1.04e-05	1466	123	23	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000	SMG1 HIF1A GPR85 PCDHB11 TTC14 DRGX HUWE1 IDS GHR RLF ZBTB37 SALL1 KLHDC10 SUCO HMGCLL1 TPBG	2.05e-05	818	123	16	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#2_top-relative-expression-ranked_1000	NR2C1 PPM1D GPR85 TTPAL HUWE1 TOX3 TPBG	2.73e-05	150	123	7	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k2
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	SMG1 MYH9 RALGAPB TTC14 HUWE1 IDS LRRC8D GHR SLIT2 MET SALL1 SCNN1B TRMT13 KLHDC10 SUCO	4.21e-05	774	123	15	gudmap_developingKidney_e15.5_cortic collect duct_1000
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 HUWE1 MED13L RLF PCNX1 SUCO UTRN	1.16e-06	188	127	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	FNIP2 HIF1A NR4A1 MET TJP1 CSMD1 PALLD	1.29e-06	191	127	7	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CAND1 MAN2A1 HUWE1 LRRC58 CNOT6 PCNX1 UTRN	1.39e-06	193	127	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|356C / Donor, Lineage, Cell class and subclass (all cells)	MAN2A1 ATXN7L1 MET FAM153B LRRC25 SCNN1B	6.44e-06	159	127	6	24f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	INPP4B SLC6A9 SLIT2 LGI2 CSMD1 PALLD	1.57e-05	186	127	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BPIFB1 TSKU MET TJP1 SCNN1B TPBG	1.77e-05	190	127	6	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 MAN2A1 NLRP1 IDS INPP4B PCNX1	1.88e-05	192	127	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MYH9 PANX2 IDS LRRC4 TLR8 PCNX1	1.94e-05	193	127	6	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	BPIFB1 LRRC4 INPP4B MET SCNN1B TPBG	1.94e-05	193	127	6	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	control-Myeloid-CD16_Monocytes\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FNIP2 NR4A1 LRRC25 RNH1 MS4A14 UTRN	2.05e-05	195	127	6	f398d08a23fdfa6202f73a7aeac3ff4c997fbdfd
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A MYH9 HUWE1 LRRC58 OGDH	2.24e-05	198	127	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A MYH9 HUWE1 LRRC58 OGDH	2.24e-05	198	127	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A MYH9 HUWE1 LRRC58 OGDH	2.30e-05	199	127	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
Disease	C-reactive protein measurement	NBPF3 NCOA6 CARMIL1 TLR8 ADCY8 SLC6A9 SALL1 LRRC25 COMMD1 NYNRIN DNAH17 PKD1 NKPD1 QSER1	1.93e-04	1206	112	14	EFO_0004458
Disease	Copper-Overload Cirrhosis	MET COMMD1	7.68e-04	11	112	2	C1876165
Disease	Malignant neoplasm of breast	NCOA6 HIF1A MYH9 PPM1D PANX2 INPP4B NSUN6 TOX3 SCNN1B CLSPN KLHDC10 FASTKD3	7.94e-04	1074	112	12	C0006142
Disease	iron biomarker measurement	CARMIL1 GHR MS4A14	8.13e-04	48	112	3	EFO_0004461
Disease	Sarcomatoid Renal Cell Carcinoma	PIDD1 INPP4B MET PRAME	1.46e-03	128	112	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	PIDD1 INPP4B MET PRAME	1.46e-03	128	112	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	PIDD1 INPP4B MET PRAME	1.46e-03	128	112	4	C1266044
Disease	Papillary Renal Cell Carcinoma	PIDD1 INPP4B MET PRAME	1.46e-03	128	112	4	C1306837
Disease	Renal Cell Carcinoma	PIDD1 INPP4B MET PRAME	1.46e-03	128	112	4	C0007134
Disease	lateral occipital cortex volume measurement	RAB44 UTRN	1.87e-03	17	112	2	EFO_0010311
Disease	ovarian cancer (is_marker_for)	HIF1A MET UTRN	2.23e-03	68	112	3	DOID:2394 (is_marker_for)
Disease	primary ciliary dyskinesia (implicated_via_orthology)	SLIT2 ZMYND10	2.34e-03	19	112	2	DOID:9562 (implicated_via_orthology)
Disease	sensorineural hearing loss (implicated_via_orthology)	ZMYND10 DNAH17	2.34e-03	19	112	2	DOID:10003 (implicated_via_orthology)
Disease	visceral adipose tissue measurement	CARMIL1 ADCY8 SH2B1 SLIT2 GPR158 PKD1 HMGCLL1	2.44e-03	481	112	7	EFO_0004765
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PIDD1 INPP4B MET PRAME	2.48e-03	148	112	4	C0279702
Disease	diabetic nephropathy	ALLC MYH9 TBC1D31 GPR158	2.60e-03	150	112	4	EFO_0000401
Disease	respiratory symptom measurement, COVID-19	SALL1 CSMD1 RAVER1	2.84e-03	74	112	3	EFO_0007939, MONDO_0100096
Disease	gamma-glutamylglutamine measurement	PPM1D SLIT2	3.14e-03	22	112	2	EFO_0021138
Disease	Hepatitis, Chronic	MET COMMD1	3.14e-03	22	112	2	C0019189
Disease	Chronic active hepatitis	MET COMMD1	3.14e-03	22	112	2	C0520463
Disease	Chronic Persistent Hepatitis	MET COMMD1	3.14e-03	22	112	2	C0149519
Disease	Cryptogenic Chronic Hepatitis	MET COMMD1	3.14e-03	22	112	2	C0524611
Disease	Liver carcinoma	INPP4B GHR SLIT2 MET IGFALS GPR158 CSMD1	3.26e-03	507	112	7	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALTRNSINLLPNHLA	ADCY8	641	P40145
LVLAPLHSLASQALE	EGFL7	216	Q9UHF1
INLTHSLLAASNPSL	nan	46	Q9N2K0
LAEHLSDQNLSVPAI	APLF	191	Q8IW19
DHNATSILQQLPLLS	BPIFB1	46	Q8TDL5
NELLGLILNSTSNHL	CSMD1	1176	Q96PZ7
LSPNQSHLFDSLTLE	ALLC	326	Q8N6M5
PHLLTEAELLQLANS	SPATA5	541	Q8NB90
LLELDLTSNQLTHLP	IGFALS	436	P35858
RQLSPSAQEHLASLQ	ANKRD24	431	Q8TF21
DLSLASHNAVSSLPL	ATXN7L1	756	Q9ULK2
ASLQLLLNPLLHGSA	RAVER1	341	Q8IY67
TPDLSAQHLQLLTDN	NR2C1	86	P13056
AHSELPQQDSLLVSL	RAB44	706	Q7Z6P3
HQASLPNTQVLLDSA	QSER1	716	Q2KHR3
PCHLANLLSTLAQSN	NOBOX	241	O60393
VLPLLNLSCSNTHLN	OR8D1	181	Q8WZ84
PANLLTSLVRAHLDS	NR4A1	361	P22736
QLLHVSSPNLASDSD	KCNA1	426	Q09470
SLTQVTDLAPSLHDL	MED13L	796	Q71F56
HLLPSQLSLSVDTAD	MAN2A1	101	Q16706
LSVLDLSHNLLHSIP	LRRIQ4	236	A6NIV6
ILLQDLSSSAPHLAN	GPR158	201	Q5T848
DPFLADLHQASSLLQ	KIAA1755	726	Q5JYT7
TLLQQPDDHAATTSL	HIF1A	736	Q16665
SLPHNQSLRASNVIL	LRRC25	51	Q8N386
QPLIATHADLLLNSA	INPP4B	421	O15327
NSAAHNKPSLIRDLL	CAND1	1031	Q86VP6
SAVLANSPSLLALRH	PCNX1	1901	Q96RV3
AFPNLANLSRTQLLH	KLHDC10	416	Q6PID8
SLQLLLQPHSLESLH	NLRP1	706	Q9C000
LNLAHNNLSSLPHDL	LRRC4	271	Q9HBW1
PLNDNIATLLHQSSD	MYH9	591	P35579
ALTLRIHDSLNNSLP	PPM1D	481	O15297
LFLQNLPSALVSHVL	NSUN6	216	Q8TEA1
AADILQLSSSLPLQS	HUWE1	2586	Q7Z6Z7
SRSLNQHLQALLTPD	NBPF1	391	Q3BBV0
ASCSLNQHLQALLTP	NBPF1	661	Q3BBV0
LPQAASHLQELLAST	IRGC	36	Q6NXR0
PQLSQLHSLRSLSLH	LRRC58	206	Q96CX6
LHLPLASLVSINTDN	PCDHB11	496	Q9Y5F2
ANPSHLTLNTALVES	PALLD	1366	Q8WX93
SLNLPHSNELCSSLV	NCOA6	1546	Q14686
TDNDIALLHLAQPAT	PROC	296	P04070
ALLHLAQPATLSQTI	PROC	301	P04070
SRSLNQHLQALLTPD	NBPF3	176	Q9H094
ITLSLVANPSHLEAA	OGDH	366	Q02218
RHLPLASLVSINADN	PCDHB14	496	Q9Y5E9
NILSSNLPAQTLDHR	ATMIN	596	O43313
NLPAQTLDHRSLLSD	ATMIN	601	O43313
IPSSLDNLLLHAIET	DNAH17	181	Q9UFH2
AHIQLSNPSSLSNID	GHR	471	P10912
ESNDLPLLTAIASTH	FNIP2	1091	Q9P278
SDAPLSQQHTLETLL	CORO6	426	Q6QEF8
HSEAVLQSANLLPST	DRGX	216	A6NNA5
LSQALSAHAILPEAS	MS4A14	406	Q96JA4
LLAAASVLNHSNQEP	ITIH6	366	Q6UXX5
PLSGLLNALAQDTFH	COMMD1	11	Q8N668
LPNLSSLTLSRNHLA	GP5	241	P40197
HNLTLLTLFENPLAE	GP5	266	P40197
HAADNILQNLSPLTA	GPR85	6	P60893
ANPLTASTLVHLDLS	CARMIL1	331	Q5VZK9
LAQPNAIVHLDLSNT	CARMIL1	361	Q5VZK9
SPNIDQLASHSLLFQ	IDS	61	P22304
ILAPELSHANATRNL	SCNN1B	126	P51168
PLSTLSSHLSQQLAA	SALL1	281	Q9NSC2
LHLSDNSLSRIPSDI	CNOT6	56	Q9ULM6
LPEASNQSLLTVAHA	FAM153B	166	P0C7A2
AALLHTNTPSINQEL	PPP6R2	351	O75170
LDLSHNQLSELHLAP	NRROS	381	Q86YC3
PHAIFSLSNLQELDL	LRRC8D	651	Q7L1W4
VLHSNLLASVPADLA	PIDD1	246	Q9HB75
LDSSNPAAGLHLQLN	PKD1	2911	P98161
PNLLALQLSDSTLAD	NYNRIN	1476	Q9P2P1
QLLAALAQSNHDATP	PANX2	381	Q96RD6
PATLDSLSIHQLAAQ	RFXANK	86	O14593
ALDPAQTSLLTNLHC	HMGCLL1	31	Q8TB92
LLQNTVHIDLSALNP	MET	1046	P08581
HSANPLLDLLVLTES	RTTN	1176	Q86VV8
NEHLVSASSNPALAL	SZT2	371	Q5T011
TVNDLSSQLSPLDLH	UTRN	2751	P46939
CLNHSESLPSQDLLL	SH2B1	411	Q9NRF2
SLENVLLTALPNHSS	TRMT13	461	Q9NUP7
SLLQLPENHTAFSTL	TBC1D31	436	Q96DN5
TDDQLLALLPSLSHC	PRAME	391	P78395
SALQSLLQHLIGLSN	PRAME	421	P78395
ALHLQTSLPALSEAD	SNAP47	396	Q5SQN1
FSHLPSLQLLLLNSN	LGI2	81	Q8N0V4
LTHLSLANNHLETLP	LGI4	126	Q8N135
LNAINTLLSDSHAPF	NKPD1	251	Q17RQ9
SRSLNEHLQALLTPD	NBPF8	356	Q3BBV2
SRSLNEHLQALLTPD	NBPF9	391	P0DPF3
SRSLNEHLQALLTPD	NBPF11	391	Q86T75
SRSLNEHLQALLTPD	NBPF12	391	Q5TAG4
ASRSLNEHLQALLTP	NBPF12	661	Q5TAG4
SRSLNEHLQALLTPD	NBPF14	51	Q5TI25
SRSLNEHLQALLTPD	NBPF26	51	B4DH59
DLLSQLQSLLGPHLD	SPATA31A6	96	Q5VVP1
NCSALQSLLHLLSSP	KPNA1	336	P52294
ALQALILLHVDPQSS	FASTKD3	181	Q14CZ7
DLLSQLQSLLGPHLD	SPATA31A7	96	Q8IWB4
LNNLLHSLQLPEACS	SMG1	576	Q96Q15
PHLLSSLAAVQTLAN	CCT8L1P	31	A6NM43
PHLLSSLAAVQTLAS	CCT8L2	31	Q96SF2
LENLPATNFSNLVHL	NOM1	736	Q5C9Z4
LSSLLELHLQIHSQP	OR6B3	316	Q8NGW1
AVLQKLAALSDHNPS	CLSPN	1261	Q9HAW4
SDLNSLHTNLPRSIL	TTPAL	256	Q9BTX7
LVSLINAHSLDPATL	RNF31	1006	Q96EP0
PSSLLDALEQHLASL	PICALM	271	Q13492
DLLSQLQSLLGPHLD	SPATA31A3	96	Q5VYP0
NEAFLNLPASLTELH	TLR8	656	Q9NR97
IPDFSNSVLSHLNQL	ZBTB37	11	Q5TC79
LPFLQSLQESHDALL	RLF	151	Q13129
DLLSQLQSLLGPHLD	SPATA31A1	96	Q5TZJ5
DLLSQLQSLLGPHLD	SPATA31A5	96	Q5VU36
SLLNLHLHALQPEDS	TRBV4-1	91	A0A577
LSSLILSANNLQHLG	TRIL	231	Q7L0X0
ALTSLSPDLRLHQQL	XYLB	111	O75191
TLPTLQELHLSDNLL	RNH1	111	P13489
ALPSNLSHLLNHSLQ	SLC6A9	246	P48067
SLLSLLRSEQQDNPH	TTC14	16	Q96N46
DTLHSLSTLNLLANP	SLIT2	651	O94813
NDLSALSHLAIGANP	SLIT2	846	O94813
NLTSSLLLNTPLSQH	TOX3	351	O15405
LEPSHSQTLSQSLLL	SUCO	721	Q9UBS9
LTLELFPNHTDNLNS	RALGAPB	1301	Q86X10
AALTHELLALDVPNT	PPP6R1	371	Q9UPN7
SLDNSPLLQSIHQLD	TRIM9	416	Q9C026
ATLLNVPDLSDSIHS	TJP1	266	Q07157
QLLALTPLHQAALAE	STRCP1	1291	A6NGW2
AQLPSLRHLDLSNNS	TPBG	231	Q13641
LTDTLLDQLPNLAHL	ZMYND10	296	O75800
LDQLPNLAHLQSFLA	ZMYND10	301	O75800
QQFPDLHSELNLSSL	TRBV9	86	A0A0B4J1U6
SPLSDVNLSHNQLRE	TSKU	131	Q8WUA8
PLCLHNSSLFALQNL	TLX2	251	O43763
ESALEAASLHPAQLL	AMDHD2	351	Q9Y303