Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-tubulin binding

PPARGC1A SETD2

6.83e-0452152GO:0043014
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

PPRC1 PPARGC1A

9.40e-0461152GO:0030374
DomainEGF

HMCN1 LRP6

4.48e-03126152PF00008
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

PPRC1 PPARGC1A

7.70e-0519102MM15973
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

PPRC1 PPARGC1A

7.70e-0519102M39544
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

TOPORS PPARGC1A

4.22e-0444102M27295
PathwayWP_ENERGY_METABOLISM

PPRC1 PPARGC1A

5.02e-0448102M39590
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

PPRC1 PPARGC1A

6.59e-0455102M27145
Pubmed

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.

PPARGC1A SETD2

1.74e-07215230406665
Pubmed

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

PPRC1 PPARGC1A

1.74e-07215216511594
Pubmed

Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells.

PPRC1 PPARGC1A

5.21e-07315211943463
Pubmed

[SIRT1/PGC-1: a neuroprotective axis?].

PPRC1 PPARGC1A

5.21e-07315217937892
Pubmed

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond.

PPRC1 PPARGC1A

5.21e-07315225495651
Pubmed

Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells.

PPRC1 PPARGC1A

5.21e-07315211340167
Pubmed

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

PPRC1 PPARGC1A

1.04e-06415214722127
Pubmed

Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.

TFPI2 PPP1R9A

6.24e-06915218480470
Pubmed

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.

TFPI2 PPP1R9A

3.28e-052015216341224
InteractionZNF816 interactions

TOPORS NKTR

6.17e-0516152int:ZNF816
InteractionZNF786 interactions

TOPORS NKTR

1.08e-0421152int:ZNF786
CytobandEnsembl 112 genes in cytogenetic band chr7q21

TFPI2 PPP1R9A

1.52e-03178152chr7q21
GeneFamilyRNA binding motif containing

PPRC1 PPARGC1A

1.15e-02213142725
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CATSPERG SULT4A1 PPARGC1A FRMD4B PPP1R9A AGAP1

2.01e-051106156M39071
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_1000

TOPORS LRP6 AGAP1

8.20e-05123153gudmap_developingGonad_e16.5_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#2_top-relative-expression-ranked_1000

TOPORS LRP6 AGAP1

1.18e-04139153gudmap_developingGonad_e18.5_epididymis_1000_k2
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

TOPORS LRP6 FRMD4B NKTR AGAP1

1.55e-04790155gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

TOPORS LRP6 FRMD4B NKTR AGAP1

1.63e-04799155gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

TOPORS LRP6 FRMD4B NKTR AGAP1

1.65e-04801155gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

TOPORS PPARGC1A FRMD4B NKTR AGAP1

1.70e-04806155gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_1000

TOPORS LRP6 AGAP1

2.70e-04184153gudmap_developingGonad_e14.5_ epididymis_1000_k2
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SULT4A1 PPARGC1A

2.02e-0516215336ddebe3bb172c992739353b7b049b2dde98b559
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A AGAP1

2.46e-051731534bc6d93716f093b460c8b047199db8cab5fea720
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 LRP6 PPARGC1A

2.46e-051731530c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

LRP6 PPP1R9A AGAP1

3.00e-0518515398b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

PPARGC1A PPP1R9A AGAP1

3.30e-051911533c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

LRP6 PPP1R9A AGAP1

3.35e-05192153efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

LRP6 NKTR PPP1R9A

3.35e-05192153916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPARGC1A PPP1R9A AGAP1

3.46e-051941537002937e8903e037332a215d00fbc7c7843b33f2
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

HMCN1 NKTR PPP1R9A

3.79e-05200153dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l32|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CATSPERG PPRC1

3.15e-047915211e92ae55dae24b6f73dd5a52e1c3c4e579ddf7b
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CATSPERG TFPI2

4.94e-049915298c40a27432929434879c9e7283a14102f405f39
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CATSPERG TFPI2

4.94e-0499152d6bd8075dc7aba2034ea78b1389868282bc80a2d
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SULT4A1

6.43e-04113152ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

HMCN1 AGAP1

7.24e-041201527f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-8|TCGA-Kidney / Sample_Type by Project: Shred V9

CATSPERG GPR6

7.60e-04123152967f20fcb27c9989de93f4183038334105910175
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CATSPERG TFPI2

9.42e-041371524dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CATSPERG TFPI2

9.42e-04137152c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP6 SETD2

1.05e-03145152cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP6 SETD2

1.05e-0314515280684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPRC1 PPP1R9A

1.11e-031491523378d0fe79de6d7879fd48717ded5027593c785f
ToppCellVE-CD8-memory_CD4|VE / Condition, Cell_class and T cell subcluster

HMCN1 AGAP1

1.16e-031521529401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TFPI2 SETD2

1.17e-0315315232cf4ca828d228f23366480305592f9813fed7ff
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TFPI2 SETD2

1.17e-03153152d5f5399ebbbff508c96ce7f01272716b61597ab5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

TOPORS TFPI2

1.20e-031551529d53caee196b5c2bbc90c4f54f693b64d4086065
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP6 PPRC1

1.22e-03156152e0aef6104be16b12304b8e30358f444c1660e92f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP6 PPRC1

1.22e-031561525b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

HMCN1 SULT4A1

1.25e-03158152ab05f6d7968ccd6d3826cd71b763dbedc83822c3
ToppCellControl-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

FRMD4B PPP1R9A

1.26e-031591526f50c381cd8a26a5a90bf0ce909713cea96910d7
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRMD4B ZNF80

1.28e-03160152c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PPARGC1A AGAP1

1.34e-03164152f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PPARGC1A AGAP1

1.34e-03164152b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

SETD2 PPP1R9A

1.38e-0316615232d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF80 PPP1R9A

1.39e-0316715242b299273a6c72a625b204d55f4f3c4eebd6d185
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNF80 PPP1R9A

1.39e-0316715294642b3dae035fedb6e8b9745f440096a4539f3c
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF80 PPP1R9A

1.39e-03167152ecf5bc634e1e01efd783617eb81d1704e903ea21
ToppCellControl|World / group, cell type (main and fine annotations)

PPP1R9A AGAP1

1.41e-03168152a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-DC1|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SULT4A1 AGAP1

1.43e-03169152319511ea57bbd72c2d95e8516d093689df67a912
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPARGC1A PPP1R9A

1.43e-03169152aec97583b23112060437b619cb429dc32f29285f
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CATSPERG FRMD4B

1.44e-031701520272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CATSPERG FRMD4B

1.44e-03170152f664c7559e383b37845c123e41a3be316d869ba0
ToppCellnormal-na-Lymphocytic_NK-natural_killer_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CATSPERG PPP1R9A

1.46e-03171152d339840626211a7bf1a9eb8f14d6c9509ab05e1c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPRC1 AGAP1

1.49e-031731525295ed31648abf8edff214cf67cd4769f20f9e6d
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

FRMD4B PPP1R9A

1.49e-03173152090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

PPARGC1A PPP1R9A

1.55e-0317615236f77d878a53b30465b0dea8333a3865dba75613
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 PPARGC1A

1.55e-03176152749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TFPI2 AGAP1

1.55e-03176152bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L6_SST_NPY_(Sst_Chodl)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMD4B GPR6

1.56e-031771520979e3a9150b3ebc64fe045792a7740a82f7bc2e
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

PPARGC1A AGAP1

1.58e-0317815235a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellControl-T/NK-NK|Control / Disease group,lineage and cell class （2021.01.30）

ZNF80 PPP1R9A

1.58e-03178152079fd19bdeed86bf985c4083af432432d66ad546
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.58e-031781524df6218b20c2f076c22346d23260964cc0d73e65
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TFPI2 PPP1R9A

1.60e-03179152f2e8fc975c30992611630197b79daaeef7c4211d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.60e-03179152666072c0e8448dbaec1683d18368ec2502453f90
ToppCellCOPD-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

SULT4A1 GPR6

1.60e-03179152988d0853c391da1e5004f73f3678047418d3f6d3
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

FRMD4B PPP1R9A

1.62e-03180152198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMCN1 PPP1R9A

1.62e-0318015225f8e82bbc1853cb7d072484e99369c72779dd1e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.63e-03181152e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

SETD2 ZNF80

1.63e-03181152b193f3606554adc55c5906219d114288bb1f978a
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TFPI2 GPR6

1.63e-03181152af031661af28f99d906d8e013b4949133b44a2e6
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

PPP1R9A AGAP1

1.63e-03181152c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SULT4A1 PPP1R9A

1.65e-03182152b8be66a867ea1bbae0820b26dbd55b68611f5ad5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.65e-031821525f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SULT4A1 PPP1R9A

1.65e-03182152cb488f9a9b200e2557335ccf22535cd247512cdc
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.67e-031831522f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A FRMD4B

1.67e-0318315204d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FRMD4B NKTR

1.67e-031831524d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPARGC1A PPP1R9A

1.67e-03183152262387ee8d43b96e5f1a77c75124459a506a6172
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.67e-031831522e831a4d99c6f983793df71c0994124c943c6da9
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPARGC1A PPP1R9A

1.67e-03183152c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 PPARGC1A

1.69e-03184152ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PPP1R9A AGAP1

1.69e-03184152102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 PPARGC1A

1.69e-031841522cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 PPARGC1A

1.69e-031841522b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A FRMD4B

1.69e-031841527f6c8912677764d438ab0555faca344d74c2f483
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.69e-03184152e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A PPP1R9A

1.70e-03185152af86e75096c1812ae27a78405355957ee8043d84
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

PPP1R9A AGAP1

1.70e-03185152673f0c688ae6984bc8027df2da335787924f4137
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

PPP1R9A AGAP1

1.70e-03185152cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PPARGC1A PPP1R9A

1.70e-03185152c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FRMD4B NKTR

1.72e-0318615240070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R9A AGAP1

1.72e-03186152b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellCOPD-Epithelial-Club|World / Disease state, Lineage and Cell class

PPP1R9A AGAP1

1.72e-031861523006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

PPP1R9A AGAP1

1.72e-031861529798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4B AGAP1

1.72e-03186152b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A FRMD4B

1.74e-03187152d413fb4b1531b297af5012a392b88128510c2de8
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

PPP1R9A AGAP1

1.74e-0318715281cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellCOPD-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

FRMD4B AGAP1

1.74e-03187152406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

HMCN1 TFPI2

1.74e-031871527375f70a970a5d5a58b7c33ada2dcf6dcef525c6
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRMD4B ZNF80

1.74e-031871524527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.76e-03188152eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRMD4B AGAP1

1.76e-03188152ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.76e-03188152bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A FRMD4B

1.76e-031881528de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

PPARGC1A PPP1R9A

1.76e-031881520758b474457efa36488e0195f7357100f4b6a090
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

PPP1R9A AGAP1

1.78e-03189152f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.78e-03189152f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.78e-03189152977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.78e-031891527eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

HMCN1 FRMD4B

1.78e-03189152c81787a8c662db5d7814c583dd64562857629e81
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 PPARGC1A

1.78e-03189152975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

PPARGC1A PPP1R9A

1.78e-031891529c1debd65c13d63fd4f3158917d621b44b714c26
Drugtert-butyl hydroperoxide

LRP6 PPRC1 PPARGC1A TFPI2 SETD2 NKTR

1.40e-05902156CID000006410
DrugAr 1

PPRC1 PPARGC1A

5.48e-0517152CID000009027
DrugDequalinium dichloride [522-51-0]; Down 200; 7.6uM; HL60; HT_HG-U133A

TOPORS FRMD4B NKTR

1.87e-041741531276_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

LRP6 SETD2 PPP1R9A

2.45e-041911534279_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

TOPORS PPRC1 NKTR

2.45e-041911531057_DN
Drug17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

LRP6 PPRC1 NKTR

2.49e-04192153993_DN
Drug1kkq

PPRC1 PPARGC1A

2.52e-0436152CID000446738
DrugS x H

PPRC1 ZNF80

2.52e-0436152CID009549209
DrugFolinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; MCF7; HT_HG-U133A

SULT4A1 FRMD4B NKTR

2.53e-041931534725_UP
DrugCP-645525-01 [287190-82-3]; Down 200; 10uM; MCF7; HT_HG-U133A

LRP6 TFPI2 PPP1R9A

2.57e-041941537515_DN
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A

TOPORS SETD2 NKTR

2.57e-041941534727_DN
DrugGalanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A

TFPI2 SETD2 NKTR

2.57e-041941534772_DN
DrugChicago sky blue 6B [2610-05-1]; Up 200; 4uM; MCF7; HT_HG-U133A

LRP6 SETD2 NKTR

2.61e-041951534971_UP
DrugCefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; PC3; HT_HG-U133A

SETD2 NKTR PPP1R9A

2.65e-041961532072_UP
DrugTranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; PC3; HT_HG-U133A

SETD2 NKTR PPP1R9A

2.65e-041961532101_UP
DrugNicergoline; Up 200; 8.2uM; PC3; HT_HG-U133A

LRP6 NKTR PPP1R9A

2.65e-041961532058_UP
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

LRP6 TFPI2 NKTR

2.69e-041971537476_DN
DrugVinpocetine [42971-09-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A

TOPORS LRP6 SETD2

2.69e-041971537213_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; PC3; HT_HG-U133A

LRP6 PPRC1 NKTR

2.69e-041971531215_DN
DrugGlycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A

SULT4A1 LRP6 SETD2

2.73e-041981535316_UP
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; HL60; HG-U133A

TOPORS FRMD4B SETD2

2.73e-041981531415_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

TFPI2 SETD2 NKTR

2.73e-041981531650_DN
DrugOmeprazole [73590-58-6]; Down 200; 11.6uM; PC3; HT_HG-U133A

LRP6 PPRC1 NKTR

2.73e-041981536606_DN
DrugPivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SULT4A1 FRMD4B SETD2

2.77e-041991533535_DN
DrugSerotonin hydrochloride [153-98-0]; Down 200; 18.8uM; HL60; HT_HG-U133A

LRP6 SETD2 NKTR

2.77e-041991532449_DN
DrugBromperidol [10457-90-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

PPRC1 TFPI2 NKTR

2.77e-041991532872_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A

LRP6 NKTR PPP1R9A

2.77e-041991534765_DN
DrugPivampicillin [33817-20-8]; Up 200; 8.6uM; MCF7; HT_HG-U133A

LRP6 TFPI2 PPP1R9A

2.81e-042001535465_UP
Diseasefatty liver disease (implicated_via_orthology)

LRP6 PPARGC1A

9.64e-0531142DOID:9452 (implicated_via_orthology)
DiseaseHuntington's disease (is_marker_for)

PPARGC1A PPP1R9A

2.84e-0453142DOID:12858 (is_marker_for)
Diseasethalamus volume

PPARGC1A AGAP1

7.30e-0485142EFO_0006935
Diseaseresting heart rate

PPARGC1A FRMD4B

2.21e-03149142EFO_0004351
DiseaseParkinson's disease (implicated_via_orthology)

PPRC1 PPARGC1A

2.45e-03157142DOID:14330 (implicated_via_orthology)
Diseasereaction time measurement

PPARGC1A SETD2 PPP1R9A

3.34e-03658143EFO_0008393
Diseasegout

PPARGC1A FRMD4B

3.79e-03196142EFO_0004274
DiseaseQRS duration

HMCN1 PPARGC1A

8.54e-03298142EFO_0005055

Protein segments in the cluster

PeptideGeneStartEntry
YYFTGTYTTLYERNR

CATSPERG

316

Q6ZRH7
YHYYSRMANYRNTSE

AGAP1

156

Q9UPQ3
RYLSLYNALTYYSRR

GPR6

166

P46095
THRSYSYRPYSYRHF

LRP6

1511

O75581
YSHLYSSYSEYRNSR

HMCN1

5391

Q96RW7
SSRSCYYYESSHYRH

PPARGC1A

596

Q9UBK2
YYYESSHYRHRTHRN

PPARGC1A

601

Q9UBK2
SSAHYGYERQRDYSR

FRMD4B

841

Q9Y2L6
RRYSSYRSHDHYQRQ

PPRC1

1516

Q5VV67
HSRSRSYTYDSYYSR

NKTR

1396

P30414
SYTYDSYYSRSRSRS

NKTR

1401

P30414
SYYQFHRSLRTMSYR

SULT4A1

141

Q9BR01
NLSYSRSERSHYYDS

SETD2

416

Q9BYW2
RSERSHYYDSDRRYH

SETD2

421

Q9BYW2
HYYDSDRRYHRSSPY

SETD2

426

Q9BYW2
FYYSYSLTRHTRSHT

ZNF80

226

P51504
HSERKYYYYERHRSR

TOPORS

756

Q9NS56
YYYYERHRSRSLSSN

TOPORS

761

Q9NS56
RYYYDRYTQSCRQFL

TFPI2

51

P48307
YMHSDYNVYRVRSRY

PPP1R9A

396

Q9ULJ8