Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	testosterone 16-alpha-hydroxylase activity	CYP3A4 CYP3A43	9.46e-05	4	80	2	GO:0008390
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC5A10 CATSPER1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	1.00e-04	465	80	9	GO:0046873
GeneOntologyMolecularFunction	vitamin D 23-hydroxylase activity	CYP3A4 CYP3A43	1.57e-04	5	80	2	GO:0062179
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A4 CYP3A43	1.57e-04	5	80	2	GO:0050649
GeneOntologyMolecularFunction	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	CYP3A4 CYP3A43	1.57e-04	5	80	2	GO:0062181
GeneOntologyMolecularFunction	vitamin D 24-hydroxylase activity	CYP3A4 CYP3A43	2.35e-04	6	80	2	GO:0070576
GeneOntologyMolecularFunction	vitamin D3 25-hydroxylase activity	CYP3A4 CYP3A43	2.35e-04	6	80	2	GO:0030343
GeneOntologyMolecularFunction	vitamin D 25-hydroxylase activity	CYP3A4 CYP3A43	3.29e-04	7	80	2	GO:0070643
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP3A4 CYP3A43 CYP2U1	3.39e-04	34	80	3	GO:0008395
GeneOntologyMolecularFunction	gated channel activity	CATSPER1 CLCN1 ASIC1 KCNS1 KCNG3 RYR3 ITPR1	3.84e-04	334	80	7	GO:0022836
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor	CYP3A4 CYP3A43	4.37e-04	8	80	2	GO:0033695
GeneOntologyMolecularFunction	caffeine oxidase activity	CYP3A4 CYP3A43	4.37e-04	8	80	2	GO:0034875
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A4 CYP3A43	4.37e-04	8	80	2	GO:0101021
GeneOntologyMolecularFunction	monoatomic cation channel activity	CATSPER1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	4.50e-04	343	80	7	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	CATSPER1 CLCN1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	5.00e-04	459	80	8	GO:0005216
GeneOntologyMolecularFunction	estrogen 16-alpha-hydroxylase activity	CYP3A4 CYP3A43	8.52e-04	11	80	2	GO:0101020
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC5A10 CATSPER1 CLCN1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	8.74e-04	758	80	10	GO:0015318
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC5A10 CATSPER1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	8.92e-04	627	80	9	GO:0022890
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP3A4 CYP3A43 CYP2U1	9.99e-04	49	80	3	GO:0016712
GeneOntologyMolecularFunction	channel activity	CATSPER1 CLCN1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	1.19e-03	525	80	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CATSPER1 CLCN1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	1.21e-03	526	80	8	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC5A10 CATSPER1 CLCN1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	1.23e-03	793	80	10	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC5A10 CATSPER1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1	1.33e-03	664	80	9	GO:0008324
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP3A4 CYP3A43	1.40e-03	14	80	2	GO:0008401
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH or CH2 groups	CYP3A4 CYP3A43	1.61e-03	15	80	2	GO:0016725
GeneOntologyMolecularFunction	odorant binding	OR8U1 OR5K3 OR8U9 OR8U8	1.70e-03	127	80	4	GO:0005549
GeneOntologyMolecularFunction	calcium channel activity	CATSPER1 ORAI3 RYR3 ITPR1	1.80e-03	129	80	4	GO:0005262
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR3 ITPR1	2.33e-03	18	80	2	GO:0015278
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	CATSPER1 ASIC1 RYR3 ITPR1	2.42e-03	140	80	4	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CATSPER1 ORAI3 RYR3 ITPR1	3.18e-03	151	80	4	GO:0015085
GeneOntologyMolecularFunction	telomerase RNA binding	EXOSC10 SMG6	4.48e-03	25	80	2	GO:0070034
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNS1 KCNG3	5.60e-03	28	80	2	GO:0005251
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CATSPER1 CLCN1 KCNS1 KCNG3	6.16e-03	182	80	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CATSPER1 CLCN1 KCNS1 KCNG3	6.40e-03	184	80	4	GO:0022832
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	CATSPER1 ASIC1	6.84e-03	31	80	2	GO:0022839
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR3 ITPR1	6.84e-03	31	80	2	GO:0099604
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC5A10 CATSPER1 CLCN1 SLC34A1 ASIC1 ORAI3 KCNS1 KCNG3 RYR3 ITPR1 SLC52A3	7.23e-03	1180	80	11	GO:0022857
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CATSPER1 ASIC1 RYR3 ITPR1	7.56e-03	193	80	4	GO:0015276
GeneOntologyMolecularFunction	olfactory receptor activity	OR8U1 OR52D1 OR5K3 OR1L3 OR8U9 OR8U8	7.66e-03	431	80	6	GO:0004984
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR3 ITPR1	7.72e-03	33	80	2	GO:0005217
GeneOntologyMolecularFunction	ligand-gated channel activity	CATSPER1 ASIC1 RYR3 ITPR1	8.11e-03	197	80	4	GO:0022834
Domain	RFX1_trans_act	RFX2 RFX3	5.15e-05	3	78	2	IPR007668
Domain	RFX1_trans_act	RFX2 RFX3	5.15e-05	3	78	2	PF04589
Domain	Ion_trans_dom	CATSPER1 KCNS1 KCNG3 RYR3 ITPR1	1.15e-04	114	78	5	IPR005821
Domain	Ion_trans	CATSPER1 KCNS1 KCNG3 RYR3 ITPR1	1.15e-04	114	78	5	PF00520
Domain	Cyt_P450_E_grp-II	CYP3A4 CYP3A43	1.71e-04	5	78	2	IPR002402
Domain	Cyt_P450_E_CYP3A	CYP3A4 CYP3A43	2.55e-04	6	78	2	IPR008072
Domain	RIH_assoc	RYR3 ITPR1	2.55e-04	6	78	2	PF08454
Domain	RIH_assoc-dom	RYR3 ITPR1	2.55e-04	6	78	2	IPR013662
Domain	RIH_dom	RYR3 ITPR1	2.55e-04	6	78	2	IPR000699
Domain	Ins145_P3_rcpt	RYR3 ITPR1	2.55e-04	6	78	2	IPR014821
Domain	Ryanodine_recept-rel	RYR3 ITPR1	2.55e-04	6	78	2	IPR015925
Domain	-	RYR3 ITPR1	2.55e-04	6	78	2	1.25.10.30
Domain	RYDR_ITPR	RYR3 ITPR1	2.55e-04	6	78	2	PF01365
Domain	Ins145_P3_rec	RYR3 ITPR1	2.55e-04	6	78	2	PF08709
Domain	K_chnl_volt-dep_Kv9	KCNS1 KCNG3	3.57e-04	7	78	2	IPR003971
Domain	RFX_DNA_binding	RFX2 RFX3	6.08e-04	9	78	2	PF02257
Domain	DNA-bd_RFX	RFX2 RFX3	6.08e-04	9	78	2	IPR003150
Domain	RFX_DBD	RFX2 RFX3	6.08e-04	9	78	2	PS51526
Domain	CYSTEINE_SWITCH	MMP27 ADAMTS18 MMP7	6.66e-04	41	78	3	PS00546
Domain	MIR	RYR3 ITPR1	7.58e-04	10	78	2	PS50919
Domain	MIR	RYR3 ITPR1	7.58e-04	10	78	2	PF02815
Domain	MIR	RYR3 ITPR1	7.58e-04	10	78	2	SM00472
Domain	MIR_motif	RYR3 ITPR1	7.58e-04	10	78	2	IPR016093
Domain	Pept_M10_metallopeptidase	MMP27 ADAMTS18 MMP7	7.67e-04	43	78	3	IPR001818
Domain	Cyt_P450_CS	CYP3A4 CYP3A43 CYP2U1	1.41e-03	53	78	3	IPR017972
Domain	CYTOCHROME_P450	CYP3A4 CYP3A43 CYP2U1	1.74e-03	57	78	3	PS00086
Domain	Channel_four-helix_dom	CATSPER1 KCNS1 KCNG3	1.74e-03	57	78	3	IPR027359
Domain	-	CATSPER1 KCNS1 KCNG3	1.74e-03	57	78	3	1.20.120.350
Domain	Pept_M10A_Zn_BS	MMP27 MMP7	1.75e-03	15	78	2	IPR021158
Domain	-	CYP3A4 CYP3A43 CYP2U1	1.83e-03	58	78	3	1.10.630.10
Domain	p450	CYP3A4 CYP3A43 CYP2U1	1.83e-03	58	78	3	PF00067
Domain	Cyt_P450	CYP3A4 CYP3A43 CYP2U1	2.02e-03	60	78	3	IPR001128
Domain	ARM-type_fold	URB1 RSPH14 USP9X NOC4L RYR3 ITPR1	2.93e-03	339	78	6	IPR016024
Domain	PG_binding_1	MMP27 MMP7	3.12e-03	20	78	2	PF01471
Domain	Peptidoglycan-bd-like	MMP27 MMP7	3.12e-03	20	78	2	IPR002477
Domain	M10A_MMP	MMP27 MMP7	4.12e-03	23	78	2	IPR033739
Domain	Pept_M10A	MMP27 MMP7	4.12e-03	23	78	2	IPR021190
Domain	Peptidase_M10	MMP27 MMP7	4.48e-03	24	78	2	PF00413
Domain	MetalloPept_cat_dom	MMP27 ADAMTS18 MMP7	4.73e-03	81	78	3	IPR024079
Domain	-	MMP27 ADAMTS18 MMP7	4.73e-03	81	78	3	3.40.390.10
Domain	K_chnl_volt-dep_Kv	KCNS1 KCNG3	5.65e-03	27	78	2	IPR003968
Domain	Olfact_rcpt	OR8U1 OR52D1 OR5K3 OR1L3 OR8U9 OR8U8	6.01e-03	393	78	6	IPR000725
Domain	ZnMc	MMP27 MMP7	6.50e-03	29	78	2	SM00235
Domain	Peptidase_Metallo	MMP27 MMP7	6.50e-03	29	78	2	IPR006026
Domain	LRRNT	LRIT2 AMIGO3 LRRTM2	8.02e-03	98	78	3	IPR000372
Domain	ZINC_PROTEASE	MMP27 ADAMTS18 MMP7	8.02e-03	98	78	3	PS00142
Domain	LRRNT	LRIT2 AMIGO3 LRRTM2	8.02e-03	98	78	3	SM00013
Domain	VG_K_chnl	KCNS1 KCNG3	8.36e-03	33	78	2	IPR028325
Domain	-	SH3TC2 MAU2 ANAPC5 SMG6	1.10e-02	207	78	4	1.25.40.10
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP3A4 CYP3A43 CYP2U1	6.01e-05	18	61	3	MM14843
Pubmed	The frameshift polymorphism CYP3A43_74_delA is associated with poor differentiation of breast tumors.	CYP3A4 CYP3A43	5.36e-06	2	81	2	20715157
Pubmed	Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.	CYP3A4 CYP3A43	5.36e-06	2	81	2	32301865
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP3A4 CYP3A43 CYP2U1	5.43e-06	15	81	3	29968852
Pubmed	Intergenic mRNA molecules resulting from trans-splicing.	CYP3A4 CYP3A43	1.60e-05	3	81	2	11726664
Pubmed	CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism.	CYP3A4 CYP3A43	1.60e-05	3	81	2	21148252
Pubmed	Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme.	CYP3A4 CYP3A43	1.60e-05	3	81	2	23370405
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX2 RFX3	1.60e-05	3	81	2	15024578
Pubmed	Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study.	CYP3A4 CYP3A43	1.60e-05	3	81	2	37258238
Pubmed	Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants.	CYP3A4 CYP3A43	1.60e-05	3	81	2	28567424
Pubmed	Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.	CYP3A4 CYP3A43	1.60e-05	3	81	2	23846873
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	1.60e-05	3	81	2	12403718
Pubmed	Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol.	CYP3A4 CYP3A43	1.60e-05	3	81	2	2402224
Pubmed	A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.	CYP3A4 CYP3A43	1.60e-05	3	81	2	25005602
Pubmed	Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.	CYP3A4 CYP3A43	1.60e-05	3	81	2	11284050
Pubmed	Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones.	CYP3A4 CYP3A43	1.60e-05	3	81	2	14733933
Pubmed	Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.	CYP3A4 CYP3A43	1.60e-05	3	81	2	12147261
Pubmed	High fat diet induced obesity is mitigated in Cyp3a-null female mice.	CYP3A4 CYP3A43	1.60e-05	3	81	2	29738703
Pubmed	A novel female-specific member of the CYP3A gene subfamily in the mouse liver.	CYP3A4 CYP3A43	1.60e-05	3	81	2	10775455
Pubmed	Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.	CYP3A4 CYP3A43	1.60e-05	3	81	2	21081028
Pubmed	Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.	CYP3A4 CYP3A43	1.60e-05	3	81	2	1339292
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX2 RFX3	1.60e-05	3	81	2	8289803
Pubmed	Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain.	CYP3A4 CYP3A43	1.60e-05	3	81	2	12617959
Pubmed	Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment.	CYP3A4 CYP3A43	1.60e-05	3	81	2	19226368
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	1.60e-05	3	81	2	10330134
Pubmed	Genetic analysis of sensitization and tolerance to cocaine.	CYP3A4 CYP3A43	1.60e-05	3	81	2	7932176
Pubmed	Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.	CYP3A4 CYP3A43	1.60e-05	3	81	2	9143324
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	1.60e-05	3	81	2	22415835
Pubmed	Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.	CYP3A4 CYP3A43	1.60e-05	3	81	2	19188337
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	1.60e-05	3	81	2	32725242
Pubmed	Screening for SH3TC2, PMP2, and BSCL2 Variants in a Cohort of Chinese Patients with Charcot-Marie-Tooth.	SH3TC2 BSCL2	1.60e-05	3	81	2	29336362
Pubmed	Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.	CYP3A4 CYP3A43	1.60e-05	3	81	2	22291988
Pubmed	Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.	CYP3A4 CYP3A43	1.60e-05	3	81	2	26212543
Pubmed	CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.	CYP3A4 CYP3A43	1.60e-05	3	81	2	15548719
Pubmed	Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver.	CYP3A4 CYP3A43	3.20e-05	4	81	2	21088200
Pubmed	Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.	CYP3A4 CYP3A43	3.20e-05	4	81	2	12958193
Pubmed	Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.	CYP3A4 CYP3A43	3.20e-05	4	81	2	23709690
Pubmed	Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.	CYP3A4 CYP3A43	3.20e-05	4	81	2	26903378
Pubmed	iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis.	CYP3A4 CYP3A43	3.20e-05	4	81	2	32130917
Pubmed	Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.	CYP3A4 CYP3A43	3.20e-05	4	81	2	36050438
Pubmed	Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.	CYP3A4 CYP3A43	3.20e-05	4	81	2	25319358
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX2 RFX3	3.20e-05	4	81	2	11682486
Pubmed	A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.	CYP3A4 CYP3A43	3.20e-05	4	81	2	7813478
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR3 ITPR1	3.20e-05	4	81	2	9607712
Pubmed	CYP3A4 and pregnane X receptor humanized mice.	CYP3A4 CYP3A43	3.20e-05	4	81	2	17936928
Pubmed	The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice.	CYP3A4 CYP3A43	3.20e-05	4	81	2	30796914
Pubmed	Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer.	CYP3A4 CYP3A43	3.20e-05	4	81	2	23656416
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX2 RFX3	3.20e-05	4	81	2	19596083
Pubmed	Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.	CYP3A4 CYP3A43	3.20e-05	4	81	2	17975676
Pubmed	Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).	CYP3A4 CYP3A43	3.20e-05	4	81	2	7803471
Pubmed	Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice.	CYP3A4 CYP3A43	3.20e-05	4	81	2	31633069
Pubmed	A map of the mouse Cyp3a locus.	CYP3A4 CYP3A43	3.20e-05	4	81	2	14509827
Pubmed	Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.	CYP3A4 CYP3A43	3.20e-05	4	81	2	27638959
Pubmed	Humanized xenobiotic response in mice expressing nuclear receptor SXR.	CYP3A4 CYP3A43	3.20e-05	4	81	2	10935643
Pubmed	Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes.	CYP3A4 CYP3A43	3.20e-05	4	81	2	10230766
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR3 ITPR1	3.20e-05	4	81	2	23413940
Pubmed	Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.	CYP3A4 CYP3A43	3.20e-05	4	81	2	23125282
Pubmed	Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.	CYP3A4 CYP3A43 LPCAT3	3.42e-05	27	81	3	28167773
Pubmed	Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.	CYP3A4 CYP3A43	5.33e-05	5	81	2	29191818
Pubmed	OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.	CYP3A4 CYP3A43	5.33e-05	5	81	2	32087611
Pubmed	Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.	CYP3A4 CYP3A43	5.33e-05	5	81	2	11266076
Pubmed	Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.	CYP3A4 CYP3A43	5.33e-05	5	81	2	19920203
Pubmed	Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.	CYP3A4 CYP3A43	5.33e-05	5	81	2	29125184
Pubmed	P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.	CYP3A4 CYP3A43	5.33e-05	5	81	2	23090875
Pubmed	Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.	CYP3A4 CYP3A43	5.33e-05	5	81	2	18156313
Pubmed	Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes.	CYP3A4 CYP3A43	5.33e-05	5	81	2	29725048
Pubmed	Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone.	CYP3A4 CYP3A43	5.33e-05	5	81	2	8006463
Pubmed	Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.	CYP3A4 CYP3A43	7.99e-05	6	81	2	21351274
Pubmed	Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice.	CYP3A4 CYP3A43	7.99e-05	6	81	2	21193583
Pubmed	Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver.	CYP3A4 CYP3A43	7.99e-05	6	81	2	20926756
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR3 ITPR1	7.99e-05	6	81	2	23463619
Pubmed	Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.	CYP3A4 CYP3A43	7.99e-05	6	81	2	22503787
Pubmed	Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol.	CYP3A4 CYP3A43	7.99e-05	6	81	2	8043019
Pubmed	Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice.	CYP3A4 CYP3A43	7.99e-05	6	81	2	14642533
Pubmed	Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.	CYP3A4 CYP3A43	7.99e-05	6	81	2	26265742
Pubmed	LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.	CYP3A4 CYP3A43	7.99e-05	6	81	2	15930522
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR3 ITPR1	7.99e-05	6	81	2	16844763
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR3 ITPR1	7.99e-05	6	81	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR3 ITPR1	7.99e-05	6	81	2	25966694
Pubmed	The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.	CYP3A4 CYP3A43	1.12e-04	7	81	2	11137287
Pubmed	CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.	CYP3A4 SYVN1	1.12e-04	7	81	2	19103148
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	1.12e-04	7	81	2	22233545
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR3 ITPR1	1.12e-04	7	81	2	11860456
Pubmed	Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.	CYP3A4 CYP3A43	1.12e-04	7	81	2	27514509
Pubmed	Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.	CYP3A4 CYP3A43	1.12e-04	7	81	2	27137100
Pubmed	Joint effects of inflammation and androgen metabolism on prostate cancer severity.	CYP3A4 CYP3A43	1.12e-04	7	81	2	18566991
Pubmed	A novel transmembrane MSP-containing protein that plays a role in right ventricle development.	CYP3A4 CYP3A43	1.12e-04	7	81	2	15533722
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP3A4 CYP3A43	1.12e-04	7	81	2	30944282
Pubmed	Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.	CYP3A4 CYP3A43	1.49e-04	8	81	2	18794335
Pubmed	An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.	CYP3A4 CYP3A43	1.49e-04	8	81	2	30910785
Pubmed	Identification and characterization of human FNBP3 gene in silico.	CYP3A4 CYP3A43	1.49e-04	8	81	2	12964049
Pubmed	Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.	CYP3A4 CYP3A43	1.49e-04	8	81	2	18488193
Pubmed	The diploid genome sequence of an individual human.	OR8U1 OR8U9	1.49e-04	8	81	2	17803354
Pubmed	SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.	SYVN1 ITPR1	1.91e-04	9	81	2	17502376
Pubmed	The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.	CYP3A4 CYP3A43	1.91e-04	9	81	2	7678494
Pubmed	Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.	CYP3A4 CYP3A43	1.91e-04	9	81	2	3917435
Pubmed	Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.	CYP3A4 CYP3A43	2.38e-04	10	81	2	26165599
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	RFX2 RFX3	2.91e-04	11	81	2	18218630
Pubmed	Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.	CYP3A4 CYP3A43	2.91e-04	11	81	2	27904043
Pubmed	Sequence diversity and haplotype structure at the human CYP3A cluster.	CYP3A4 CYP3A43	4.11e-04	13	81	2	16314882
Pubmed	Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.	USP9X ANAPC5	4.79e-04	14	81	2	29183995
Cytoband	7q21.1	CYP3A4 CYP3A43	8.55e-05	8	81	2	7q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	ORC5 CYP3A4 CYP3A43 GPC2	6.29e-04	219	81	4	chr7q22
GeneFamily	Cytochrome P450 family 3	CYP3A4 CYP3A43	3.09e-04	8	61	2	1002
GeneFamily	Regulatory factor X family	RFX2 RFX3	3.09e-04	8	61	2	1153
GeneFamily	Olfactory receptors, family 8	OR8U1 OR8U9 OR8U8	6.03e-04	49	61	3	155
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP27 MMP7	2.95e-03	24	61	2	891
Coexpression	GSE19374_UNINF_VS_LISTERIA_INFECTED_MACROPHAGE_DN	SH3TC2 SZT2 CYP3A43 LRRTM2 NOC4L IRGC SMG6	2.52e-06	198	80	7	M7265
Coexpression	GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_DN	SH3TC2 SZT2 SLC34A1 LRRTM2 IRGC TEX14	2.99e-05	195	80	6	M7263
Coexpression	GSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_DN	SZT2 RPS6KA1 ORAI3 ZNF571 ZNF229 ANAPC5	3.44e-05	200	80	6	M9859
Drug	isradipine	CATSPER1 CYP3A4 ASIC1 ORAI3 RYR3 ITPR1	1.23e-06	100	78	6	CID000003784
Drug	felodipine	CATSPER1 CYP3A4 CYP3A43 ORAI3 CYP2U1 RYR3 ITPR1	1.86e-06	169	78	7	CID000003333
Drug	nilvadipine	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	1.95e-06	60	78	5	CID000004494
Drug	lercanidipine	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	2.49e-06	63	78	5	CID000065866
Drug	lamotrigine	CATSPER1 CYP3A4 ASIC1 ORAI3 RYR3 ITPR1	2.93e-06	116	78	6	CID000003878
Drug	bepridil	CATSPER1 CYP3A4 ASIC1 ORAI3 RYR3 ITPR1	4.73e-06	126	78	6	CID000002351
Drug	ethosuximide	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	5.55e-06	74	78	5	CID000003291
Drug	nisoldipine	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	7.20e-06	78	78	5	CID000004499
Drug	phenytoin	CATSPER1 CYP3A4 ASIC1 ORAI3 DMWD RYR3 ITPR1	1.02e-05	219	78	7	CID000001775
Drug	halothane	CATSPER1 MGST1 CYP3A4 CYP3A43 ORAI3 CYP2U1 RYR3 ITPR1	1.21e-05	314	78	8	CID000003562
Drug	manidipine	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	1.89e-05	95	78	5	CID000004008
Drug	nitrendipine	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	2.19e-05	98	78	5	CID000004507
Drug	gabapentin	CATSPER1 CYP3A4 ASIC1 ORAI3 RYR3 ITPR1	2.53e-05	169	78	6	CID000003446
Drug	loperamide	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	3.06e-05	105	78	5	CID000003954
Drug	2-aminopyrimidine	MGST1 CYP3A4	3.47e-05	3	78	2	ctd:C012180
Drug	Cinildipine	CATSPER1 ORAI3 RYR3 ITPR1	4.09e-05	56	78	4	CID000002752
Drug	5248896; Up 200; 11uM; MCF7; HT_HG-U133A_EA	URB1 RSPH14 SZT2 CYP3A4 LPCAT3 ZNF571	5.47e-05	194	78	6	955_UP
Drug	Dehydrocholic acid [81-23-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	URB1 SZT2 ASIC1 RFX2 ITPR1 SMG6	6.12e-05	198	78	6	1523_UP
Drug	mibefradil	CATSPER1 CYP3A4 ORAI3 RYR3	6.93e-05	64	78	4	CID000060662
Drug	pimozide	CATSPER1 CYP3A4 ORAI3 RYR3 ITPR1	7.60e-05	127	78	5	CID000016362
Drug	gallopamil	CATSPER1 ORAI3 RYR3 ITPR1	8.29e-05	67	78	4	CID000001234
Drug	T0702	SOCS6 RYR3 ITPR1	8.43e-05	25	78	3	CID000005908
Drug	AC1L2AC7	CATSPER1 ORAI3 RYR3 ITPR1	9.30e-05	69	78	4	CID000068733
Disease	non-alcoholic fatty liver disease	SLC34A1 PIP5K1B MAU2 EYA2 SMG6	1.24e-04	182	78	5	EFO_0003095
Disease	DNA repair protein RAD51 homolog 4 measurement	CYP3A4 TEX14	3.74e-04	11	78	2	EFO_0801531
Disease	methionine sulfone measurement	CYP3A4 CYP3A43	4.48e-04	12	78	2	EFO_0800072
Disease	metabolonic lactone sulfate measurement	CYP3A4 CYP3A43	1.15e-03	19	78	2	EFO_0800659
Disease	epiandrosterone sulfate measurement	CYP3A4 CYP3A43	1.99e-03	25	78	2	EFO_0021120
Disease	hemoglobin A1 measurement	TSHZ3 SRGAP3 LPCAT3 RPS6KA1 EYA2 SMG6	2.56e-03	520	78	6	EFO_0007629

Protein segments in the cluster

Peptide	Gene	Start	Entry
RFILSFLHAHGKLFT	SMG6	891	Q86US8
HILTGLGSYLHILFS	ACER3	221	Q9NUN7
RDYRGHFNTTHLLAL	C8orf74	96	Q6P047
THSFAIYHQSLFRIL	CATSPER1	531	Q8NEC5
LFLTRLFTFHGHSRS	APCDD1L	296	Q8NCL9
RGLAAHRHLFLSTYF	CFAP161	226	Q6P656
GSFLVHHFLSFYLKA	ELP6	31	Q0PNE2
HAFHGLRALSHLYLG	AMIGO3	151	Q86WK7
AYHYARLGSHLVLTA	HSD11B1L	46	Q7Z5J1
ESLFLASHASGHLYL	DMWD	226	Q09019
VYLSLFIHGLATHSS	DMXL1	2326	Q9Y485
SLHYRFSAFGQELHL	ADAMTS18	96	Q8TE60
LRHSNLSLVFHYVFL	IQCH	906	Q86VS3
AFALHFYRSLVAHKT	ORAI3	261	Q9BRQ5
HSEAFGFILLYVRGH	KCNG3	66	Q8TAE7
LHHSLFTAFSQFGLL	RDM1	31	Q8NG50
THSLLHYFDRLILTG	ANAPC5	271	Q9UJX4
ALFHTILTFRLSYCH	OR8U8	156	P0C7N1
YHKSLSLFIFGIVHL	MMP27	491	Q9H306
LIAISYGFILHAVFH	OR52D1	216	Q9H346
INFLYAATHELGHSL	MMP7	206	P09237
NFAHFLRLSSLHTLF	LRRTM2	221	O43300
YSAFHLGHLREVRLF	MAGEC3	51	Q8TD91
SLFRFKHLATGHYLA	ITPR1	301	Q14643
HYFLLVLVFLDTHAA	LRIT2	6	A6NDA9
FSHSYGRLYAQHALI	GPC2	126	Q8N158
HFRLFVGARIYHTIA	MGST1	106	P10620
AVSLVLLYLYGTHSH	CYP3A4	16	P08684
SGSGHHLVRFYFLTR	PCED1A	101	Q9H1Q7
DYSLLLGIHFLDHSL	PIP5K1B	266	O14986
ETYLIHLFHTFTGLS	LPCAT3	66	Q6P1A2
FLSLLHFYRTGHLHV	KCNS1	111	Q96KK3
HSLIAEFILTGFTYH	OR5K3	6	A6NET4
ALFHTILTFRLSYCH	OR8U9	156	P0C7N5
FLIRVSHSHVGYTLS	HSH2D	56	Q96JZ2
DALLIHSLRGYHRSF	IRGC	291	Q6NXR0
TGYLHHITRLVVASF	SLC34A1	241	Q06495
LLAHLARVYGSIFSF	CYP2U1	106	Q7Z449
FIGHYLVVVLSDFHS	CYP2U1	121	Q7Z449
AVDLEHHSYRSFLGL	EXOSC10	311	Q01780
ATSLVLLYIYGTHSH	CYP3A43	16	Q9HB55
SGNALFHASTLHRLY	EIF3A	286	Q14152
IHYSGFLHLELLSSY	EPM2AIP1	276	Q7L775
FILSSGSRLGRVYHH	CDC20B	326	Q86Y33
FYRGHSDDIISLALH	EML5	56	Q05BV3
IHAHFTGLRYLLYNF	BSCL2	216	Q96G97
YLALLGFAEHFRTSS	MAU2	26	Q9Y6X3
RFFHLADLFLSSSHL	NOC4L	346	Q9BVI4
FSYFHSLLHVLLVNR	OR1L3	151	Q8NH93
FHLYSTHAALAALRG	OIP5	146	O43482
IFHSLLTGTFASRYG	EYA2	281	O00167
ALFHTILTFRLSYCH	OR8U1	156	Q8NH10
LDFLFVSHAYHSILT	SYVN1	151	Q86TM6
RHGYHLTTFLRHFLA	SZT2	3066	Q5T011
HSGDYFTLLRHLLNY	USP9X	1371	Q93008
DGHHSIAFLVLTFFL	SLC52A3	101	Q9NQ40
SDALRYLHFQGFIHR	TEX14	361	Q8IWB6
GFIHRSLSSYAVHII	TEX14	371	Q8IWB6
VSDHSGFHYRQFLLK	PTAR1	231	Q7Z6K3
SAASFGSFHLIRLLY	RFX2	631	P48378
SAASFGSFHLIRLLY	RFX3	616	P48380
SILQSLFGERHHFSF	ORC5	16	O43913
LVAFHRLATVYYSLH	SH3TC2	1166	Q8TF17
ARRGIFHIILSFFHS	URB1	1806	O60287
TLHGLAHIFSYERLS	ASIC1	26	P78348
RLTGHLSLASAAHLY	CHPF	211	Q8IZ52
KTHTLFSLLGLHLAY	CLCN1	836	P35523
GSLIRHLQVSHTLFY	RNF125	186	Q96EQ8
LGFHASLARTFRTYL	SRGAP3	271	O43295
AVLGSIHYLHFAVAL	SLC5A10	506	A0PJK1
IHYLHFAVALFALSG	SLC5A10	511	A0PJK1
LHITASHSVGRYAFL	RSPH14	91	Q9UHP6
RTLLYGHAVLLRHSF	RYR3	101	Q15413
LLAHYHALASFVFGS	SESN3	196	P58005
TFSGRYFHILSALLH	SLF1	461	Q9BQI6
YISHLESHLGFRLRD	TSHZ3	991	Q63HK5
GFSYSSGLLIHQRVH	ZNF229	636	Q9UJW7
SHLDFVHLTALGYTL	STRCP1	1581	A6NGW2
LLFHIFTFAYTHRLK	VN1R17P	31	Q8TDU5
TKVHSHLYIRLLGSF	TSPEAR	501	Q8WU66
TFFRGSQLTYHLRVH	ZNF571	371	Q7Z3V5
YLLSLSFRSHGKTLH	SOCS6	416	O14544
VFVSFSSLFAHLRTH	ZNF560	496	Q96MR9
FYLAELALGLDHLHS	RPS6KA1	166	Q15418