Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein kinase activity	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC TWF1 STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2 TAF1	4.99e-07	600	104	15	GO:0004672
GeneOntologyMolecularFunction	kinase activity	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC TRRAP TWF1 STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2 TAF1	2.06e-06	764	104	16	GO:0016301
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC TWF1 STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2 TAF1	3.94e-06	709	104	15	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB2 TNIK CAMK1D HIPK4 POLB MKNK2 CAMK1 TEC TRRAP TWF1 STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2 TAF1	6.66e-06	938	104	17	GO:0016772
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	CAMK1D MKNK2 CAMK1 CAMKV	1.11e-05	27	104	4	GO:0004683
GeneOntologyMolecularFunction	protein serine kinase activity	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 PRKAA2 SRPK3 DCLK2 TAF1	2.00e-05	363	104	10	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 CAMKV PRKAA2 SRPK3 DCLK2 TAF1	2.11e-05	446	104	11	GO:0004674
GeneOntologyMolecularFunction	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	GCNT2 GCNT4	8.03e-05	3	104	2	GO:0008109
GeneOntologyMolecularFunction	chromo shadow domain binding	ATRX CHAF1A	3.98e-04	6	104	2	GO:0070087
GeneOntologyMolecularFunction	chromatin binding	ATRX CHAF1A ADNP GRHL2 PPARGC1A GRHL1 NFKB1 PRKAA2 TAF1 STAG3 TOP2B HELLS	4.63e-04	739	104	12	GO:0003682
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB2 HIPK4 TEC TWF1 FRK	9.74e-04	145	104	5	GO:0004713
GeneOntologyMolecularFunction	calmodulin binding	STRN3 CAMK1D MKNK2 CAMK1 PPP3CC CAMKV	1.30e-03	230	104	6	GO:0005516
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	CAMK1D HIPK4 MKNK2 CAMK1 STK4 CAMKV SRPK3 DCLK2 TAF1	2.54e-05	307	104	9	GO:0018105
GeneOntologyBiologicalProcess	peptidyl-serine modification	CAMK1D HIPK4 MKNK2 CAMK1 STK4 CAMKV SRPK3 DCLK2 TAF1	3.43e-05	319	104	9	GO:0018209
Domain	Protein_kinase_ATP_BS	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC STK4 FRK PRKAA2 SRPK3 DCLK2	1.07e-06	379	102	12	IPR017441
Domain	Kinase-like_dom	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC TRRAP STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2	1.45e-06	542	102	14	IPR011009
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK1D MKNK2 CAMK1 CAMKV PRKAA2 DCLK2	2.08e-06	69	102	6	IPR020636
Domain	Prot_kinase_dom	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2	2.59e-06	489	102	13	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC STK4 FRK CAMKV PRKAA2 SRPK3 DCLK2	2.84e-06	493	102	13	PS50011
Domain	PROTEIN_KINASE_ATP	EPHB2 TNIK CAMK1D HIPK4 MKNK2 CAMK1 TEC STK4 FRK PRKAA2 SRPK3 DCLK2	7.68e-06	459	102	12	PS00107
Domain	Glyco_trans_14	GCNT2 GCNT4 XYLT2	8.68e-06	8	102	3	IPR003406
Domain	Branch	GCNT2 GCNT4 XYLT2	8.68e-06	8	102	3	PF02485
Domain	S_TKc	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 CAMKV PRKAA2 SRPK3 DCLK2	2.70e-05	359	102	10	SM00220
Domain	Pkinase	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 CAMKV PRKAA2 SRPK3 DCLK2	4.46e-05	381	102	10	PF00069
Domain	Rhs_assc_core	TENM2 TENM3	8.83e-05	3	102	2	IPR022385
Domain	Ser/Thr_kinase_AS	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 PRKAA2 SRPK3 DCLK2	1.48e-04	357	102	9	IPR008271
Domain	PROTEIN_KINASE_ST	TNIK CAMK1D HIPK4 MKNK2 CAMK1 STK4 PRKAA2 SRPK3 DCLK2	1.64e-04	362	102	9	PS00108
Domain	Tox-GHH_dom	TENM2 TENM3	1.76e-04	4	102	2	IPR028916
Domain	Tox-GHH	TENM2 TENM3	1.76e-04	4	102	2	PF15636
Domain	Ten_N	TENM2 TENM3	1.76e-04	4	102	2	IPR009471
Domain	Ten_N	TENM2 TENM3	1.76e-04	4	102	2	PF06484
Domain	TENEURIN_N	TENM2 TENM3	1.76e-04	4	102	2	PS51361
Domain	SH3_1	SORBS1 TEC NEB FRK SNX9 SKAP2	2.81e-04	164	102	6	PF00018
Domain	YD	TENM2 TENM3	2.92e-04	5	102	2	IPR006530
Domain	CP2	GRHL2 GRHL1	4.37e-04	6	102	2	PF04516
Domain	CP2	GRHL2 GRHL1	4.37e-04	6	102	2	IPR007604
Domain	DUF1220	NBPF4 NBPF6	1.04e-03	9	102	2	SM01148
Domain	SH3	SORBS1 TEC NEB FRK SNX9 SKAP2	1.20e-03	216	102	6	SM00326
Domain	SH3	SORBS1 TEC NEB FRK SNX9 SKAP2	1.20e-03	216	102	6	PS50002
Domain	Na_channel_asu	SCN4A SCN8A	1.29e-03	10	102	2	IPR001696
Domain	Na_trans_assoc	SCN4A SCN8A	1.29e-03	10	102	2	IPR010526
Domain	Na_trans_assoc	SCN4A SCN8A	1.29e-03	10	102	2	PF06512
Domain	SH3_domain	SORBS1 TEC NEB FRK SNX9 SKAP2	1.31e-03	220	102	6	IPR001452
Domain	DUF1220	NBPF4 NBPF6	1.57e-03	11	102	2	PF06758
Domain	NBPF_dom	NBPF4 NBPF6	1.57e-03	11	102	2	IPR010630
Domain	NBPF	NBPF4 NBPF6	1.57e-03	11	102	2	PS51316
Domain	NHL	TENM2 TENM3	2.22e-03	13	102	2	PS51125
Domain	CarboxyPept-like_regulatory	TENM2 TENM3	3.81e-03	17	102	2	IPR008969
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	FLII ATRX POLB CHAF1A ADNP INTS3 TRRAP BRD9 TAF1 SNX9 TOP2B HELLS	1.09e-07	533	108	12	30554943
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK PEG3 SORBS1 TENM2 STRIP1 TENM3 SUGP2 SIPA1L1 MTCL1 USP15	6.03e-07	407	108	10	12693553
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	INTS3 TRRAP SERPINB12 SNX9 KIAA2012 STAG3 TOP2B HELLS	2.26e-06	272	108	8	31010829
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII NDST1 KDM5B ITCH ATRX CORO2A PEG3 SORBS1 CAMK1 CFAP298 OTOF FEZ1 SIPA1L1 DCLK2 TAF1 REPS2	2.29e-06	1285	108	16	35914814
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KDM5B ITCH HIPK4 SORBS1 TWF1 STK4 SIPA1L1 ARFGAP1 PRKAA2 ASS1 SRPK3 DCLK2 MTCL1	2.83e-06	861	108	13	36931259
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FLII STRN3 ATRX CHAF1A YTHDC2 INTS3 TRRAP STRIP1 SUGP2 SIPA1L1 ARFGAP1 TOP2B	5.37e-06	774	108	12	15302935
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	ITCH SNX9 USP15	8.14e-06	13	108	3	23146885
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK FLII STRN3 ITCH GRIA1 SORBS1 ADNP TENM2 STRIP1 TWF1 CAMKV SIPA1L1 MTCL1	9.44e-06	963	108	13	28671696
Pubmed	High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii.	PPARGC1A PRKAA2	9.55e-06	2	108	2	28973039
Pubmed	NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia.	PPARGC1A NFKB1	9.55e-06	2	108	2	35883637
Pubmed	AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells.	PPARGC1A PRKAA2	9.55e-06	2	108	2	18974883
Pubmed	Inhibiting PDGF-D alleviates the symptoms of HELLP by suppressing NF-κB activation.	NFKB1 PDGFD	9.55e-06	2	108	2	33640869
Pubmed	Disparity between microRNA levels and promoter strength is associated with initiation rate and Pol II pausing.	NFKB1 TAF1	9.55e-06	2	108	2	23831825
Pubmed	Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.	GRHL2 GRHL1	9.55e-06	2	108	2	29309642
Pubmed	NF-kappaB regulates the transcription of protein tyrosine kinase Tec.	TEC NFKB1	9.55e-06	2	108	2	19843184
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	RBBP5 POLB ADNP TRRAP GRHL2 HELLS	1.43e-05	167	108	6	20362541
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KDM5B ATRX NOP16 CHAF1A INTS3 TRRAP NFKB1 TOP2B HELLS	1.64e-05	469	108	9	27634302
Pubmed	Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.	STRN3 STRIP1 USP15	1.92e-05	17	108	3	29299163
Pubmed	Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.	GCNT2 GGTA1 ORM2 ASS1	2.29e-05	53	108	4	7774911
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	SORBS1 FRK SNX9 SKAP2	2.85e-05	56	108	4	22745667
Pubmed	The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.	POLB CHAF1A	2.86e-05	3	108	2	17173071
Pubmed	Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.	GRHL2 GRHL1	2.86e-05	3	108	2	24375798
Pubmed	A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.	GRHL2 GRHL1	2.86e-05	3	108	2	12175488
Pubmed	Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.	GRHL2 GRHL1	2.86e-05	3	108	2	12393799
Pubmed	A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.	BRD9 TAF1	2.86e-05	3	108	2	26365797
Pubmed	The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.	GRHL2 GRHL1	2.86e-05	3	108	2	12549979
Pubmed	Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.	KDM5B USP15	2.86e-05	3	108	2	28344757
Pubmed	Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling.	PPARGC1A NFKB1	2.86e-05	3	108	2	23563317
Pubmed	Roles of Grainyhead-like transcription factors in cancer.	GRHL2 GRHL1	2.86e-05	3	108	2	28714958
Pubmed	Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer.	GRHL2 GRHL1	2.86e-05	3	108	2	26069269
Pubmed	The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.	ATRX BRD9	2.86e-05	3	108	2	32457312
Pubmed	Downregulation of m6A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway.	YTHDC2 NFKB1	2.86e-05	3	108	2	34326699
Pubmed	The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.	PPARGC1A NFKB1	2.86e-05	3	108	2	23223635
Pubmed	Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development.	GRHL2 GRHL1	2.86e-05	3	108	2	16831572
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TNIK STRN3 ATRX YTHDC2 ADNP TWF1 STK4 SUGP2 ARFGAP1 SNX9 TOP2B HELLS	3.45e-05	934	108	12	33916271
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF4 NBPF6 NBPF5P	3.72e-05	21	108	3	16079250
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	EPHB2 BRINP1 GSTM3 PPP3CC CAMKV SLC20A1 ASS1 DCUN1D3	4.03e-05	405	108	8	38187761
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	EPHB2 KDM5B POLB GRIA1 CAMK1 GCNT4 GRHL2 SUGP2 PRKAA2 SARDH	5.70e-05	686	108	10	29987050
Pubmed	Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140.	ORM2 NFKB1	5.71e-05	4	108	2	8754826
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM2 TENM3	5.71e-05	4	108	2	10225957
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.	PPARGC1A NFKB1	5.71e-05	4	108	2	20404331
Pubmed	Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.	SIPA1L1 NFKB1	5.71e-05	4	108	2	24133254
Pubmed	Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.	GRHL2 GRHL1	5.71e-05	4	108	2	35013237
Pubmed	The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis.	KLHL15 DCLK2	5.71e-05	4	108	2	33199366
Pubmed	Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth.	CAMK1D CAMK1	5.71e-05	4	108	2	17056143
Pubmed	Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.	CAMK1D CAMK1	5.71e-05	4	108	2	12935886
Pubmed	Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.	ITCH NFKB1	5.71e-05	4	108	2	22507528
Pubmed	MST1 modulates Th17 activation in psoriasis via regulating TLR4-NF-κB pathway.	STK4 NFKB1	5.71e-05	4	108	2	32930944
Pubmed	A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.	PPARGC1A PRKAA2	5.71e-05	4	108	2	32243780
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM2 TENM3	5.71e-05	4	108	2	12000766
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	TNIK FLII EPPK1 CORO2A GRIA1 SORBS1 SIPA1L1 REPS2	6.13e-05	430	108	8	32581705
Pubmed	The protein interaction landscape of the human CMGC kinase group.	HIPK4 NOP16 POLB MKNK2 CAMK1 NEB SUGP2 SIPA1L1 SRPK3 NSMCE4A	6.35e-05	695	108	10	23602568
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ATRX ADNP TRRAP GRHL2 SUGP2 TOP2B	6.69e-05	220	108	6	35785414
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ATRX RBBP5 YTHDC2 ADNP TRRAP SNX9 USP15 TOP2B	7.19e-05	440	108	8	34244565
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TNIK STRN3 PKD1L1 HAUS3 SORBS1 PHAF1 SIPA1L1 NFKB1 ARFGAP1 SNX9 USP15	7.20e-05	853	108	11	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ALLC RBBP5 CHAF1A ADNP INTS3 TRRAP SUGP2 NFKB1 SNX9 TOP2B HELLS	7.51e-05	857	108	11	25609649
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FLII YTHDC2 HAUS3 PHAF1 SUGP2 BRD9 SNX9 TOP2B NSMCE4A HELLS	8.90e-05	724	108	10	36232890
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	FLII ATRX INTS3	9.02e-05	28	108	3	24462114
Pubmed	Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.	STRN3 STK4	9.50e-05	5	108	2	32589942
Pubmed	Cryo-EM structure of the Hippo signaling integrator human STRIPAK.	STRN3 STRIP1	9.50e-05	5	108	2	33633399
Pubmed	Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.	STRN3 STRIP1	9.50e-05	5	108	2	30622739
Pubmed	AMPK and PPARdelta agonists are exercise mimetics.	PPARGC1A PRKAA2	9.50e-05	5	108	2	18674809
Pubmed	LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-κB pathway by sponging miR-576-5p.	PPP3CC NFKB1	9.50e-05	5	108	2	37660994
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN4A SCN8A	9.50e-05	5	108	2	17724025
Pubmed	Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP.	PPARGC1A NFKB1	9.50e-05	5	108	2	17785586
Pubmed	PEG3 controls lipogenesis through ACLY.	PEG3 HMGCR	9.50e-05	5	108	2	34048454
Pubmed	CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.	STRN3 STRIP1	9.50e-05	5	108	2	25743393
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ATRX RBBP5 CHAF1A ADNP TRRAP BRD9 TAF1 TOP2B HELLS	1.21e-04	608	108	9	36089195
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	EPHB2 TEC FRK	1.35e-04	32	108	3	7542761
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ATRX NOP16 RBBP5 XYLT2 SUGP2 TOP2B	1.38e-04	251	108	6	28077445
Pubmed	The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.	ITCH SNX9	1.42e-04	6	108	2	20491914
Pubmed	Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.	ORM2 PRKAA2	1.42e-04	6	108	2	36050503
Pubmed	Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons.	PPARGC1A PRKAA2	1.42e-04	6	108	2	26926143
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	STRN3 STRIP1	1.42e-04	6	108	2	25531779
Pubmed	Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.	CAMK1 DCLK2	1.42e-04	6	108	2	16684769
Pubmed	Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells.	HMGCR PRKAA2	1.42e-04	6	108	2	31167140
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	ATRX PEG3 ADNP TOP2B	1.54e-04	86	108	4	37253089
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	HIPK4 FRK CAMKV KLHL15 PRKAA2 SRPK3 DCLK2	1.67e-04	372	108	7	22939624
Pubmed	Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice.	GRHL2 GRHL1	1.99e-04	7	108	2	27907249
Pubmed	SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division.	SYCP2 STAG3	1.99e-04	7	108	2	15870106
Pubmed	The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.	TENM2 TENM3	1.99e-04	7	108	2	10625539
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM2 TENM3	1.99e-04	7	108	2	12915301
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TNIK FLII STRN3 GRIA1 SORBS1 TENM2 SUGP2 CAMKV SIPA1L1 ARFGAP1 DCLK2 USP15	2.23e-04	1139	108	12	36417873
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	ITCH ATRX HELLS	2.27e-04	38	108	3	11555636
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ATRX YTHDC2 ADNP SUGP2 TAF1 TOP2B	2.63e-04	283	108	6	30585729
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM2 TENM3	2.64e-04	8	108	2	10331952
Pubmed	High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.	HAUS3 OTOF	2.64e-04	8	108	2	21118569
Pubmed	Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.	HMGCR PPARGC1A	2.64e-04	8	108	2	24371122
Pubmed	Ca(2+)/CaM-dependent kinases: from activation to function.	CAMK1D CAMK1	2.64e-04	8	108	2	11264466
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	BNC2 SORBS1 STK4 TENM3 SUGP2 FARS2 SIPA1L1 NFKB1	2.76e-04	536	108	8	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	BNC2 SORBS1 STK4 TENM3 SUGP2 FARS2 SIPA1L1 NFKB1	2.83e-04	538	108	8	10512203
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	KDM5B STRN3 ITCH YTHDC2 TRRAP STRIP1 FARS2 SIPA1L1 KLHL15 MTCL1 USP15	2.99e-04	1005	108	11	19615732
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	STRN3 CHAF1A TWF1 XYLT2 FAT1 NFKB1 BRD9 MTCL1 USP15	3.06e-04	689	108	9	36543142
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ATRX RBBP5 CHAF1A ADNP TRRAP SUGP2 ASS1 BRD9 TAF1 TOP2B HELLS	3.22e-04	1014	108	11	32416067
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	STRN3 STRIP1 NFKB1 MTCL1	3.30e-04	105	108	4	19156129
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN8A	3.39e-04	9	108	2	16382098
Pubmed	The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.	CORO2A RBBP5	3.39e-04	9	108	2	24930734
Pubmed	TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.	TRRAP TAF1	3.39e-04	9	108	2	15899866
Pubmed	Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.	HAUS3 OTOF	3.39e-04	9	108	2	16024820
Pubmed	BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.	SYCP2 STAG3	3.39e-04	9	108	2	19531582
Interaction	STK3 interactions	STRN3 ITCH NOP16 NEB CFAP298 STRIP1 STK4 ORM2	4.81e-06	181	105	8	int:STK3
Interaction	SMARCC2 interactions	TNIK FLII KDM5B ITCH RBBP5 CHAF1A ADNP BRD9 USP15 TOP2B	1.58e-05	353	105	10	int:SMARCC2
Cytoband	1p13.3	NBPF4 NBPF6 NBPF5P STRIP1 GSTM3	6.85e-07	69	109	5	1p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p13	NBPF4 NBPF6 NBPF5P STRIP1 GSTM3	1.55e-04	211	109	5	chr1p13
GeneFamily	Glucosaminyl (N-acetyl) transferases/xylosyltransferases	GCNT2 GCNT4 XYLT2	2.57e-06	8	66	3	441
GeneFamily	Neuroblastoma breakpoint family	NBPF4 NBPF6 NBPF5P	7.81e-05	23	66	3	662
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN8A	4.65e-04	9	66	2	1203
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRN3 STRIP1	2.39e-03	20	66	2	1371
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_MESENCHYMAL_3_CELL	EPHB2 CAMK1D PEG3 TENM3 IQCA1 PDGFD ASS1	6.63e-06	174	105	7	M45676
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	EPHB2 KDM5B STRN3 ITCH ATRX ADNP TRRAP FAT1 FARS2 SIPA1L1 NFKB1 MTCL1 USP15 SKAP2	8.25e-06	856	105	14	M4500
Coexpression	GSE20198_IL12_VS_IFNA_TREATED_ACT_CD4_TCELL_DN	TNIK KDM5B ATRX RASGEF1A ADNP STRIP1 GRHL1	1.59e-05	199	105	7	M7374
Coexpression	GSE34515_CD16_POS_MONOCYTE_VS_DC_DN	CAMK1D CAMK1 FBXL4 GSTM3 XYLT2 PHAF1 REPS2	1.64e-05	200	105	7	M8763
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	ATRX PEG3 GRIA1 SLC6A15 SORBS1 NEB TENM2 STRIP1 ZNF248 PPARGC1A SUGP2 PRKAA2 SCN8A DCLK2 SARDH	3.46e-05	1106	105	15	M39071
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 SORBS1 BSND PPARGC1A TENM3 PDGFD DCLK2 TEC	2.40e-08	191	109	8	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST1 HAUS3 GGTA1 ZNF248 FRK TRMT44 SARDH	1.64e-07	164	109	7	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST1 HAUS3 GGTA1 ZNF248 FRK TRMT44 SARDH	1.64e-07	164	109	7	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EPHB2 TNIK BNC2 TENM2 FRK TENM3 SRPK3	3.99e-07	187	109	7	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	Basal_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	EPPK1 GRIA1 SLC6A15 TENM2 PPARGC1A PRKAA2	3.07e-06	163	109	6	679e25e5548d157d49a73057a3b5617dccda260f
ToppCell	NS-critical-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 BSND PPARGC1A TENM3 SRPK3 DCLK2	5.97e-06	183	109	6	ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LIAS CHAF1A PEG3 SORBS1 TENM3 IQCA1	5.97e-06	183	109	6	1464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EPHB2 BNC2 TENM2 FRK TENM3 SRPK3	6.35e-06	185	109	6	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	TNIK BNC2 SORBS1 GCNT4 NFKB1 MTCL1	6.55e-06	186	109	6	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNC2 HIPK4 RASGEF1A GRIA1 TENM2 CAMKV	6.75e-06	187	109	6	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNC2 HIPK4 RASGEF1A GRIA1 TENM2 CAMKV	6.75e-06	187	109	6	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNC2 HIPK4 RASGEF1A GRIA1 TENM2 CAMKV	6.75e-06	187	109	6	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	TNIK SORBS1 GCNT2 TENM2 PPARGC1A PRKAA2	7.40e-06	190	109	6	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	droplet-Skin-nan-21m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNIK KDM5B EPPK1 GRHL1 SERPINB12 SIPA1L1	7.62e-06	191	109	6	c5ef34d138cd797029dfefaf4c52d16ba6a76c38
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK SORBS1 GCNT2 TENM2 PPARGC1A PRKAA2	8.58e-06	195	109	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	KDM5B MKNK2 PPP3CC SUGP2 NFKB1 MTCL1	8.58e-06	195	109	6	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	mild-Treg\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK HAUS3 GCNT4 STK4 USP15 HELLS	9.09e-06	197	109	6	39800e6e83f2d333b753d121c7aeb2912b91faa2
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNIK BNC2 FEZ1 DRAXIN NFKB1 PDGFD	9.36e-06	198	109	6	326e97bdc27cc3440f5488c2519446580cdc9d51
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNIK BNC2 FEZ1 DRAXIN NFKB1 PDGFD	9.36e-06	198	109	6	2fdb92b198ba24e326e90479fd024400d956fb32
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	GRIA1 TENM2 TENM3 FEZ1 DCLK2 REPS2	9.91e-06	200	109	6	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A GCNT2 PPARGC1A SLC20A1 REPS2	5.84e-05	168	109	5	03896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SORBS1 BSND PPARGC1A TENM3 DCLK2	6.18e-05	170	109	5	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	facs-Trachea-nan-24m-Myeloid-lymphocyte_of_B_lineage\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIPA1L1 SCN4A ASS1 SRPK3 TEC	6.71e-05	173	109	5	71c90c57225e452c73bf7bea46b454c472bf5f76
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	EPHB2 FAT1 TENM3 OTOF MTCL1	6.89e-05	174	109	5	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PEG3 ADNP TENM3 DRAXIN SCN8A	7.08e-05	175	109	5	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PEG3 ADNP TENM3 DRAXIN SCN8A	7.08e-05	175	109	5	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A CRELD2 HAUS3 GGTA1 CAMKV	7.28e-05	176	109	5	35610e7ac9902687e222641202409bab279c3998
ToppCell	Hippocampus\|World / BrainAtlas - Mouse McCarroll V32	GRIA1 NEB GRHL1 CAMKV BRD9	7.28e-05	176	109	5	f120a703f6d2f2d5f55eae1aea2e6382a485828f
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 SORBS1 BSND PPARGC1A DCLK2	7.47e-05	177	109	5	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK4 RASGEF1A GRIA1 CAMKV OTOF	7.68e-05	178	109	5	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK4 RASGEF1A GRIA1 CAMKV OTOF	7.68e-05	178	109	5	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 BSND PPARGC1A SRPK3 DCLK2	8.09e-05	180	109	5	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	TNIK SORBS1 GCNT4 NFKB1 MTCL1	8.52e-05	182	109	5	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	critical-Epithelial-Ionocyte\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 BSND PPARGC1A SRPK3 DCLK2	8.97e-05	184	109	5	58d36577eff814d46d72f031f3533d71549e3d6e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EPHB2 TNIK BNC2 GRIA1 TENM3	9.44e-05	186	109	5	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGEF1A GRIA1 CAMKV OTOF SCN8A	9.44e-05	186	109	5	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	EPPK1 GRHL2 TENM2 GRHL1 SERPINB12	9.68e-05	187	109	5	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	TNIK GCNT2 TENM2 PPARGC1A PRKAA2	9.93e-05	188	109	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	COVID-19-Epithelial-Ionocytes\|COVID-19 / Condition, Lineage and Cell class	BSND PPARGC1A FAT1 PDGFD PRKAA2	9.93e-05	188	109	5	a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	TNIK GCNT2 TENM2 PPARGC1A PRKAA2	1.02e-04	189	109	5	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 GRIA1 TENM3 FEZ1 PDGFD	1.02e-04	189	109	5	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK BNC2 FAT1 IQCA1 MTCL1	1.02e-04	189	109	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Control-Lymphoid-NK\|World / Disease state, Lineage and Cell class	BNC2 STK4 PPP3CC FEZ1 PDGFD	1.02e-04	189	109	5	89ef0d0e66dc96cacaae6be7aacdaa884e8e66a8
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	TNIK BNC2 FAT1 MTCL1 ABCC2	1.02e-04	189	109	5	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHB2 GRHL1 OTOF SNX9 DCUN1D3	1.04e-04	190	109	5	e59e3ad044af7b4409d5ecbd326fe83862e5fc9a
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	BNC2 SORBS1 FAT1 DCLK2 MTCL1	1.04e-04	190	109	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK TENM2 GRHL1 PRKAA2 REPS2	1.04e-04	190	109	5	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	TNIK BNC2 SORBS1 GCNT4 MTCL1	1.04e-04	190	109	5	379dbac19110b76079a7a53209569e060a852acb
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	CAMK1D CHAF1A MEIKIN SIPA1L1 NFKB1	1.04e-04	190	109	5	4e481e42353d47af7991744000403af2873f6a41
ToppCell	Control-Lymphoid-NK\|Control / Disease state, Lineage and Cell class	BNC2 STK4 PPP3CC FEZ1 PDGFD	1.04e-04	190	109	5	f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	CHAF1A MEIKIN SIPA1L1 NFKB1 SNX9	1.07e-04	191	109	5	11dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	SORBS1 GCNT2 TENM2 PPARGC1A PRKAA2	1.07e-04	191	109	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	TNIK GCNT2 TENM2 PPARGC1A PRKAA2	1.10e-04	192	109	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NDST1 SORBS1 PPARGC1A ASS1 SARDH	1.10e-04	192	109	5	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 GRIA1 TENM3 FEZ1 PDGFD	1.10e-04	192	109	5	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	EPHB2 BRINP1 TENM3 PDGFD ASS1	1.10e-04	192	109	5	d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGEF1A GRIA1 CAMKV OTOF SCN8A	1.12e-04	193	109	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK SORBS1 TENM2 PPARGC1A PRKAA2	1.12e-04	193	109	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	CAMK1D CHAF1A MEIKIN STK4 NFKB1	1.12e-04	193	109	5	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ATRX RASGEF1A SLC6A15 CAMKV SCN8A	1.12e-04	193	109	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGEF1A GRIA1 CAMKV OTOF SCN8A	1.12e-04	193	109	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGEF1A GRIA1 CAMKV OTOF SCN8A	1.12e-04	193	109	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK PPARGC1A FRK FAT1 PRKAA2	1.15e-04	194	109	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GRHL2 PPARGC1A FRK FAT1 PRKAA2	1.15e-04	194	109	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	IPF-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	CAMK1D MEIKIN STK4 SIPA1L1 NFKB1	1.15e-04	194	109	5	accf4b7b09e2048f2e47a52201e0158684dda8fe
ToppCell	droplet-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B EPPK1 CAMK1D POLB GRHL1	1.15e-04	194	109	5	592e8c4b73ba424a52305ac411ea9c0a2dc44467
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NEB BSND SCN8A SRPK3 STAG3	1.24e-04	197	109	5	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 GRHL2 FAT1 PRKAA2 REPS2	1.24e-04	197	109	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	CD8+_Memory_T_cell-CV-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	TNIK FEZ1 NFKB1 SARDH SNX9	1.24e-04	197	109	5	9fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SORBS1 BSND TENM3 SRPK3 DCLK2	1.24e-04	197	109	5	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CAMK1D MEIKIN SIPA1L1 NFKB1 SNX9	1.24e-04	197	109	5	a902aa05e5f711bcfdd9e19749ab636b597eb116
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHAF1A GRHL1 SYCP2 PRKAA2 SCN8A	1.27e-04	198	109	5	28ada093cec552262731194a04a4b9ff93186c3b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PEG3 BRINP1 SORBS1 TENM2 SCN8A	1.27e-04	198	109	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 HIPK4 HAUS3 SORBS1 DCLK2	1.27e-04	198	109	5	d1827e3707b929e3a3562989a0c11537d344e164
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK BNC2 ATRX SUGP2 USP15	1.30e-04	199	109	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MEIKIN SORBS1 TENM2 IQCA1 DCLK2	1.33e-04	200	109	5	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EPHB2 BNC2 SORBS1 DCUN1D3 TEC	1.33e-04	200	109	5	36de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNIK MEIKIN SORBS1 GSTM3 IQCA1	1.33e-04	200	109	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CAMK1D INTS3 TRRAP KLHL15 TEC	1.33e-04	200	109	5	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CAMK1D INTS3 TRRAP KLHL15 TEC	1.33e-04	200	109	5	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	Endothelial-Endothelial-A\|Endothelial / shred on cell class and cell subclass (v4)	NOP16 PEG3 SORBS1 HELLS	2.30e-04	122	109	4	65849d1296934d5765afd006cbb6739383b9f49f
ToppCell	COVID-19_Mild-immature_Neutrophil\|COVID-19_Mild / Disease condition and Cell class	PKD1L1 BRINP1 ASS1 HELLS	2.37e-04	123	109	4	a6670825fd8d9f9a0111a7b68598c764c99abb0d
ToppCell	COVID-19_Mild-immature_Neutrophil-\|COVID-19_Mild / Disease condition and Cell class	PKD1L1 BRINP1 ASS1 HELLS	2.37e-04	123	109	4	5f19b0e32509bedeb9ac6c74ac7a20750798da5e
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	TNIK STRN3 CORO2A YTHDC2 FBXL4 STK4 TAF1 USP15	3.20e-06	195	104	8	3710_DN
Drug	Oleandomycin phosphate [7060-74-4]; Down 200; 5uM; MCF7; HT_HG-U133A	STRN3 ATRX YTHDC2 CAMK1 STK4 SUGP2 SIPA1L1 TAF1	3.45e-06	197	104	8	1518_DN
Drug	Nem-S-G	NFKB1 ABCC2 TOP2B	5.10e-06	8	104	3	CID000126950
Disease	autosomal dominant nonsyndromic deafness (implicated_via_orthology)	TRRAP GRHL2	1.30e-05	2	107	2	DOID:0050564 (implicated_via_orthology)
Disease	high grade glioma (is_implicated_in)	KDM5B ATRX CHAF1A GSTM3	1.65e-05	42	107	4	DOID:3070 (is_implicated_in)
Disease	social interaction measurement	BRINP1 TENM2 FBXL4 STK4 SIPA1L1	2.42e-05	94	107	5	EFO_0009592
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	7.78e-05	4	107	2	EFO_0020830
Disease	Borderline personality disorder	CAMK1D XYLT2 SNX9	2.79e-04	35	107	3	HP_0012076
Disease	Myopathies, Nemaline	NEB SRPK3	3.60e-04	8	107	2	C0206157
Disease	cortical surface area measurement	TNIK BNC2 STRN3 ITCH RBBP5 CHAF1A RASGEF1A SLC6A15 HMGCR TENM2 STRIP1 NFKB1 PDGFD MTCL1	3.62e-04	1345	107	14	EFO_0010736
Disease	myositis	SLC6A15 TEC TEC	3.85e-04	39	107	3	EFO_0000783
Disease	pyoderma gangrenosum	SERPINB12 USP15	4.61e-04	9	107	2	EFO_0006835
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN8A	5.75e-04	10	107	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN8A	5.75e-04	10	107	2	DOID:0080422 (implicated_via_orthology)
Disease	cholate measurement	CAMK1D ERICH6	5.75e-04	10	107	2	EFO_0021509
Disease	glycerophosphorylcholine measurement	SLC6A15 DCLK2	7.01e-04	11	107	2	EFO_0020018
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN8A	8.40e-04	12	107	2	DOID:0060170 (implicated_via_orthology)
Disease	Congenital myopathy (disorder)	NEB SCN4A	8.40e-04	12	107	2	C0270960
Disease	nervous system disorder	ARFGAP1 SCN8A ABCC2	9.52e-04	53	107	3	C0027765
Disease	age at first birth measurement	BNC2 SLC6A15 CAMKV SIPA1L1	9.72e-04	120	107	4	EFO_0009101
Disease	obesity (implicated_via_orthology)	FLII GSTM3 STK4 PPARGC1A PRKAA2	1.14e-03	215	107	5	DOID:9970 (implicated_via_orthology)
Disease	Intellectual Disability	NDST1 GRIA1 TRRAP KLHL15 ASS1 SCN8A TAF1	1.24e-03	447	107	7	C3714756
Disease	respiratory symptom change measurement, response to placebo	PPARGC1A FARS2	1.71e-03	17	107	2	EFO_0008344, EFO_0010068
Disease	non-alcoholic fatty liver disease (is_implicated_in)	PPARGC1A ABCC2	1.92e-03	18	107	2	DOID:0080208 (is_implicated_in)
Disease	Hereditary hearing loss and deafness	GRHL2 FBXL4 OTOF SCN4A	2.00e-03	146	107	4	cv:C0236038
Disease	cystathionine measurement	TEC TEC	2.14e-03	19	107	2	EFO_0010474
Disease	end stage renal disease (implicated_via_orthology)	HMGCR ABCC2	2.37e-03	20	107	2	DOID:783 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	NDST1 KDM5B ATRX	2.59e-03	75	107	3	DOID:1059 (implicated_via_orthology)
Disease	skin hydration measurement	MKNK2 PKD1L1	2.62e-03	21	107	2	EFO_0009586
Disease	Ovarian Serous Adenocarcinoma	TRRAP CAMKV	3.14e-03	23	107	2	C1335177
Disease	type 2 diabetes mellitus (is_implicated_in)	HMGCR SORBS1 PPARGC1A PRKAA2	3.54e-03	171	107	4	DOID:9352 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FEPNDFYLKNTTWED	ADNP	41	Q9H2P0
ELEAPETFSEEYLWK	ERICH6	66	Q7L0X2
SWAEAYKDLENSDEF	BRINP1	296	O60477
TAAAPVWEEAKIFYD	NT5C1A	21	Q9BXI3
EWRSSYEDYADKPLE	BRD9	11	Q9H8M2
FEAIAELKSDDWSYL	ALLC	121	Q8N6M5
KSEDRLSEQDWPAYF	BNC2	16	Q6ZN30
EWFKQDLPSYLFPED	PRKAA2	266	P54646
LFDFTPKWRATYEDQ	FAM47DP	246	A6NHR8
PDIDLDSENILWEYF	GVINP1	1911	Q7Z2Y8
DEKNWGLSFYADKPE	ORM2	136	P19652
DKAFEDWLNDDLGSY	ARFGAP1	161	Q8N6T3
PWAQDTKLLDYEVDS	CHAF1A	586	Q13111
DLSNYSEDEAWPSLF	DCUN1D3	256	Q8IWE4
ESWNFSQDYDPELIK	IQCA1	411	Q86XH1
EFIWPAIQSSALYED	ASS1	71	P00966
DYSNPKWDETSLGFL	NBPF4	311	Q96M43
LFYDWLFFSPDKDSI	INTS3	396	Q68E01
SPDDLKYIEEFNKSW	MTCL1	1421	Q9Y4B5
PSWDFDYDTKVVDLD	FAT1	4326	Q14517
LPDVFDDLKSFESWF	HELLS	401	Q9NRZ9
KPADRAAEWYNIDFS	FLII	381	Q13045
DAANPWQLKSSADYL	HIPK4	256	Q8NE63
LLSWSKDTYSPDEHF	GCNT2	286	Q8N0V5
KDTYSPDEHFWVTLN	GCNT2	291	Q8N0V5
WNYECPKFEEDVLSS	HMGCR	46	P04035
EFPAPYWDNITDSAK	DCLK2	611	Q8N568
YEADFDSATKTFPNW	EPHB2	116	P29323
EDLLKYFNPESWQED	PDGFD	221	Q9GZP0
SIQEGKYEFPDKDWA	MKNK2	321	Q9HBH9
DAGDDLLLSYVKEFW	NDST1	371	P52848
SDSFVEDPWLSPKYD	KIAA2012	921	Q0VF49
DASEPYNTAKAIAEW	LIAS	156	O43766
ELFRKSDYLDWECPN	MEIKIN	151	A0A087WXM9
EAPDYDRSQWLDVKF	GSTM3	41	P21266
DPFNNYSDEEIWKAL	ABCC2	1396	Q92887
WDALTDNYIPSLSED	FEZ1	106	Q99689
KLSPEEEEYLDSGWN	KDM5B	446	Q9UGL1
SEAEDWETPKPFYQL	MEIOSIN	611	C9JSJ3
WAPNLYELDSDLTKE	PEG3	16	Q9GZU2
VENWSAFAPDFKELD	RBBP5	326	Q15291
EFDSPYWDDISDSAK	CAMK1	236	Q14012
FDDSEDESDKLSYPW	PPARGC1A	511	Q9UBK2
DLESIDPEFYNSLIW	ITCH	676	Q96J02
PFDLSYKTVDQWEID	FRK	216	P42685
LEENDDDAYLNSPWA	CFAP298	256	P57076
SPAPDWYKDFVTDAD	ATRX	1996	P46100
PTLDMALFDWTDYED	DRAXIN	226	Q8NBI3
ALFDWTDYEDLKPDG	DRAXIN	231	Q8NBI3
SEDEAWKSYLENPLT	GRHL2	31	Q6ISB3
YTSEDEAWKSFLENP	GRHL1	26	Q9NZI5
YSDSILTFDPDENKW	KLHL15	556	Q96M94
LWEEAAYDQSLPDFS	BSND	101	Q8WZ55
EFDSPYWDDISQAAK	CAMKV	246	Q8NCB2
VQDFFAWSKDTYSPD	GCNT4	321	Q9P109
QPYWAKLDDTSLEFL	FBXL4	326	Q9UKA2
LDVKWNPFDDFEIAS	CORO2A	86	Q92828
YPKADNLNGEDFDWL	HAUS3	16	Q68CZ6
YWNEDDKFVPAATDA	GRIA1	381	P42261
LQLKSEYPDLFEWFC	CRELD2	106	Q6UXH1
EEWYDQDKPEVSLLF	SLC20A1	501	Q8WUM9
LPVDSEKDIFDYIQW	POLB	311	P06746
TPSDFLVKQIYFWDE	PKD1L1	1626	Q8TDX9
YPKELESEFDNFEDW	OTOF	1411	Q9HC10
TWPSEIASEDYDLLF	POTEA	421	Q6S8J7
DEDWDGPKSSSYFKD	SNX9	166	Q9Y5X1
SYDLPANKDAFRKTW	STRN3	456	Q13033
AWIEDKASEEFLSYP	SLC6A15	601	Q9H2J7
DFPAADLDSLWEDFS	TRMT44	136	Q8IYL2
YETWEKFDPDATQFI	SCN4A	1621	P35499
QELSFYSIPEFDEWK	TOP2B	606	Q02880
AGFSYEKWEINPSEL	TEC	356	P42680
SFLWIYHSKNPEVDD	GGTA1	31	Q4G0N0
DYSNPKWDETSLGFL	NBPF5P	311	Q86XG9
DYSNPKWDETSLGFL	NBPF6	311	Q5VWK0
IYQFTAASPKDAEEW	SKAP2	196	O75563
DKPWYSIFPIDNEDL	TAF1	461	P21675
ATRNSDFPVWDDYKS	NPY5R	21	Q15761
DFPVWDDYKSSVDDL	NPY5R	26	Q15761
FWDLLSSPYFTEDRK	EPPK1	1796	P58107
PDLEFEYADTDKWAA	STRIP1	66	Q5VSL9
DLDWSNLVDAAKAYE	SIPA1L1	1676	O43166
ASPNLAYTFIWDKTD	TENM2	1116	Q9NT68
DSPDFEFIVYDSWKI	NSMCE4A	186	Q9NXX6
FSFQLDSWTEAPKYE	PHAF1	136	Q9BSU1
KRFYPAEWQDFLDSL	NOP16	156	Q9Y3C1
DSPYWDDISDSAKDF	CAMK1D	241	Q8IU85
KWETYFDHENTVDAP	SERPINB12	196	Q96P63
YEANPIFWEEVSDKF	SARDH	331	Q9UL12
EKYEWPLEQATQFSA	SRPK3	526	Q9UPE1
LLWSDPSEDYGNEKT	PPP3CC	226	P48454
PDATYDFKSDLWSLG	TNIK	206	Q9UKE5
LKEWTEAFPYDFQDE	RASGEF1A	121	Q8N9B8
PKWDCQLFDSYSESL	REPS2	376	Q8NFH8
DEWLDSYKQDQDAGF	STAG3	116	Q9UJ98
YELQIPSDEKLEEFW	SYCP2	291	Q9BX26
DLKNEPWYKFFSELE	SORBS1	561	Q9BX66
KEDPAYWFLSDENSL	SUGP2	611	Q8IX01
LDWDPDLKKRYFDEN	USP15	751	Q9Y4E8
ETFYEIWEKFDPDAT	SCN8A	1786	Q9UQD0
IWEKFDPDATQFIEY	SCN8A	1791	Q9UQD0
ASPNLAYTFIWDKTD	TENM3	1051	Q9P273
DFLDNPEKWNTNYTL	UBE2U	91	Q5VVX9
LTEWYSAQENSFKPE	YTHDC2	411	Q9H6S0
NSSDWKIPQDGDYEF	STK4	421	Q13043
DISFWLPSENYAEND	FARS2	366	O95363
LKEWALHTFPNATDY	TRRAP	3651	Q9Y4A5
PALKAYWENTYDAAD	XYLT2	531	Q9H1B5
DFTQEEWYLLDPAQK	ZNF248	16	Q8NDW4
SDSWDKDYDSFVLPL	TWF1	46	Q12792
LYTEDWEADKSLFYP	NEB	206	P20929
LVENFEPLYDLDDSW	NFKB1	746	P19838