Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoIncreased serum estradiol

CDKN2A ZNRF3

7.73e-05982HP:0025134
HumanPhenoElevated serum 11-deoxycortisol

CDKN2A ZNRF3

7.73e-05982HP:0025436
HumanPhenoIncreased circulating androstenedione concentration

CDKN2A ZNRF3

9.65e-051082HP:0025380
HumanPhenoAbnormal circulating androstenedione concentration

CDKN2A ZNRF3

1.18e-041182HP:0033811
HumanPhenoAdrenocorticotropic hormone deficiency

CDKN2A ZNRF3

2.24e-041582HP:0011748
HumanPhenoAbnormal circulating dehydroepiandrosterone concentration

CDKN2A ZNRF3

2.24e-041582HP:0500022
HumanPhenoIncreased urinary cortisol level

CDKN2A ZNRF3

2.56e-041682HP:0012030
HumanPhenoParadoxical increased cortisol secretion on dexamethasone suppression test

CDKN2A ZNRF3

2.56e-041682HP:0003466
HumanPhenoIncreased circulating androgen concentration

CDKN2A ZNRF3

3.26e-041882HP:0030348
HumanPhenoIncreased body weight

CDKN2A CNNM2 ZNRF3 RYR1 PROP1

3.57e-0449185HP:0004324
HumanPhenoAbnormal urine hormone level

CDKN2A ZNRF3

3.64e-041982HP:0012029
HumanPhenoAdrenal carcinoma

CDKN2A ZNRF3

3.64e-041982HP:0002889
HumanPhenoAdrenocortical carcinoma

CDKN2A ZNRF3

3.64e-041982HP:0006744
HumanPhenoLung adenocarcinoma

CDKN2A ZNRF3

4.91e-042282HP:0030078
HumanPhenoNon-small cell lung carcinoma

CDKN2A ZNRF3

5.37e-042382HP:0030358
HumanPhenoAbnormal blood potassium concentration

CDKN2A ZNRF3 RYR1

5.49e-0411383HP:0011042
HumanPhenoNeoplasm of the adrenal cortex

CDKN2A ZNRF3

7.99e-042882HP:0100641
DomainSPRY

TRIM65 TRIM4 RYR1

2.94e-0487283SM00449
DomainConA-like_dom

TRIM65 CELSR2 TRIM4 RYR1

3.02e-04219284IPR013320
DomainSPRY

TRIM65 TRIM4 RYR1

3.69e-0494283PF00622
DomainSPRY_dom

TRIM65 TRIM4 RYR1

3.69e-0494283IPR003877
DomainB30.2/SPRY

TRIM65 TRIM4 RYR1

3.81e-0495283IPR001870
DomainB302_SPRY

TRIM65 TRIM4 RYR1

3.81e-0495283PS50188
DomainZnf_C3HC4_RING-type

TRIM65 TRIM4 ZNRF3

2.12e-03172283IPR018957
Domainzf-C3HC4

TRIM65 TRIM4 ZNRF3

4.41e-03223283PF00097
DomainBBOX

TRIM65 TRIM4

4.78e-0369282SM00336
DomainButyrophylin

TRIM65 TRIM4

4.91e-0370282IPR003879
Domain-

TRIM65 TRIM4

5.05e-03712824.10.45.10
Domainzf-B_box

TRIM65 TRIM4

5.19e-0372282PF00643
DomainZF_BBOX

TRIM65 TRIM4

6.37e-0380282PS50119
DomainZnf_B-box

TRIM65 TRIM4

6.53e-0381282IPR000315
DomainZF_RING_1

TRIM65 TRIM4 ZNRF3

9.19e-03291283PS00518
DomainZF_RING_2

TRIM65 TRIM4 ZNRF3

9.81e-03298283PS50089
DomainRING

TRIM65 TRIM4 ZNRF3

1.04e-02305283SM00184
DomainZnf_RING

TRIM65 TRIM4 ZNRF3

1.25e-02326283IPR001841
Pubmed

The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation.

CDKN2A DROSHA

2.31e-06331223318441
Pubmed

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.

CDKN2A CELSR2

1.61e-05731221239051
Pubmed

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

CDKN2A CNNM2

1.61e-05731220364137
Pubmed

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

CDKN2A CELSR2

9.16e-051631219198609
Pubmed

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.

CNNM2 CELSR2

1.04e-041731221378988
Pubmed

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.

CDKN2A CELSR2

1.17e-041831220971364
Pubmed

Additive effect of multiple genetic variants on the risk of coronary artery disease.

CDKN2A CELSR2

1.30e-041931220738937
Pubmed

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.

TRIM65 PABPN1

1.45e-042031233995658
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

CELSR2 SHROOM2 DROSHA RYR1

2.02e-0432931417474147
Pubmed

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

CDKN2A DROSHA

3.29e-043031220083228
Pubmed

Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans.

CDKN2A PROP1

3.75e-043231233795686
Pubmed

Network-based prediction of protein interactions.

ZNF581 KIFC3

7.11e-044431230886144
Pubmed

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

CDKN2A CNNM2

7.43e-044531221378990
InteractionLINC01465 interactions

LINC01465 VIRMA

2.00e-062292int:LINC01465
GeneFamilyRing finger proteins

TRIM65 TRIM4 ZNRF3

3.28e-0327520358
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM65 TRIM4

4.88e-039520259
CoexpressionGSE7460_CTRL_VS_FOXP3_OVEREXPR_TCONV_1_UP

TRIM65 DNAH12 SHROOM2 PROP1

6.60e-05199294M5716
CoexpressionGSE15750_WT_VS_TRAF6KO_DAY10_EFF_CD8_TCELL_DN

CELSR2 PABPN1 PLEKHG3 BAHCC1

6.73e-05200294M3575
DiseaseAdrenocortical carcinoma

CDKN2A ZNRF3

1.13e-0418262C0206686
Diseaselarge artery stroke, coronary artery disease

CNNM2 CELSR2

2.21e-0425262EFO_0001645, EFO_0005524
Diseaseaxial length measurement

CNNM2 ZNRF3

2.10e-0377262EFO_0005318

Protein segments in the cluster

PeptideGeneStartEntry
PEAGRHRGGRRGPGP

EPM2A

91

B3EWF7
RQGGHPRGPGCHTVP

SLC4A9

611

Q96Q91
GPAPRGACEGRPKHL

BAHCC1

266

Q9P281
RARRCPGGLPGHAGG

CDKN2A

96

Q8N726
IHPVGGLRCRCPPGF

CELSR2

1266

Q9HCU4
AGPLRTPLCGGHREP

APEX2

461

Q9UBZ4
GPGPGVRRRCPGESL

PAXX

171

Q9BUH6
GPGCVRRVLPPSAHG

NKAIN3

111

Q8N8D7
IRTPLRCGVHPGPGT

METRN

236

Q9UJH8
PGGGRNPVTPRCIRH

DNAH12

2011

Q6ZR08
TPGCRGIGHIRGPRY

L3MBTL4

381

Q8NA19
GRGSGPGRRRHLVPG

PABPN1

16

Q86U42
SPGAQPQRHRPGCRG

FRMD6-AS1

136

P0C7T7
LRGGRGKHGPRPCCP

LINC02913

191

Q8NAJ2
PGGGTLRTCVLRPPG

SDR42E2

196

A6NKP2
EGPRGPHLVGPSRCL

RYR1

831

P21817
RGCPRGRGGHGARPS

DROSHA

16

Q9NRR4
AGGGRPRGPPVNRSH

PLEKHG3

1066

A1L390
HPEPRGCGAAPGRTL

TACO1

36

Q9BSH4
PFPHTGPGRLRTGRG

KIFC3

46

Q9BVG8
GGPHPPRIGGRRRFT

SHROOM2

741

Q13796
GLGCGRVRYPGPHPR

LINC01465

51

Q8N7H1
RRHSPGERGLGGPAP

CNNM2

126

Q9H8M5
VCGRGVPSGGRPPHR

TTLL11

751

Q8NHH1
PPCRRLPGAGGGRSR

PROP1

41

O75360
PGLPGHAGPCGPRAR

nan

116

Q6ZR54
GGTRGPDTPRPHRGL

ZNRF3

856

Q9ULT6
GGRPHGCPLCPRRFR

ZNF581

141

Q9P0T4
RRRLGPVPPGLCGRH

TRIM4

76

Q9C037
GPGPDPAARCPRHGR

TRIM65

86

Q6PJ69
HVVPPPRGRGRGGFG

VIRMA

1616

Q69YN4
HGRGCPGRTAPKPAV

LIPK

66

Q5VXJ0