Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	1.56e-06	24	72	4	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	2.56e-06	27	72	4	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	7.48e-06	35	72	4	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	2.91e-05	49	72	4	GO:0016712
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	3.84e-05	3	72	2	GO:0018858
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7	3.84e-05	3	72	2	GO:0008389
GeneOntologyMolecularFunction	C-acyltransferase activity	ACAT2 ACSM2A ACSM2B	5.71e-05	21	72	3	GO:0016408
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	7.66e-05	4	72	2	GO:0102391
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	3.54e-04	8	72	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	6.91e-04	11	72	2	GO:0031956
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	7.94e-04	115	72	4	GO:0004497
GeneOntologyMolecularFunction	ATPase regulator activity	DNAJC10 DNAJA2 HSPH1	9.77e-04	54	72	3	GO:0060590
GeneOntologyMolecularFunction	glucosidase activity	MGAM PGGHG	1.31e-03	15	72	2	GO:0015926
GeneOntologyMolecularFunction	Hsp70 protein binding	CDKN1B DNAJC10 DNAJA2	1.53e-03	63	72	3	GO:0030544
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	9.52e-07	22	72	4	GO:0019373
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7	8.03e-05	4	69	2	IPR008067
Domain	DOCK_N	DOCK1 DOCK5	1.34e-04	5	69	2	PF16172
Domain	DOCK_N	DOCK1 DOCK5	1.34e-04	5	69	2	IPR032376
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2J2	6.13e-04	45	69	3	IPR002401
Domain	DOCK_C	DOCK1 DOCK5	7.24e-04	11	69	2	IPR010703
Domain	DHR-1_domain	DOCK1 DOCK5	7.24e-04	11	69	2	IPR027007
Domain	DHR_2	DOCK1 DOCK5	7.24e-04	11	69	2	PS51651
Domain	DHR_1	DOCK1 DOCK5	7.24e-04	11	69	2	PS51650
Domain	DOCK-C2	DOCK1 DOCK5	7.24e-04	11	69	2	PF14429
Domain	DHR-2	DOCK1 DOCK5	7.24e-04	11	69	2	IPR027357
Domain	DHR-2	DOCK1 DOCK5	7.24e-04	11	69	2	PF06920
Domain	DOCK	DOCK1 DOCK5	7.24e-04	11	69	2	IPR026791
Domain	DnaJ	DNAJC10 DNAJA2 DNAJC5	7.41e-04	48	69	3	PF00226
Domain	DNAJ_1	DNAJC10 DNAJA2 DNAJC5	7.87e-04	49	69	3	PS00636
Domain	DNAJ_2	DNAJC10 DNAJA2 DNAJC5	7.87e-04	49	69	3	PS50076
Domain	DnaJ	DNAJC10 DNAJA2 DNAJC5	7.87e-04	49	69	3	SM00271
Domain	-	DNAJC10 DNAJA2 DNAJC5	7.87e-04	49	69	3	1.10.287.110
Domain	DnaJ_domain	DNAJC10 DNAJA2 DNAJC5	8.85e-04	51	69	3	IPR001623
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2J2	9.90e-04	53	69	3	IPR017972
Domain	TUDOR	STK31 TDRD1	1.19e-03	14	69	2	PF00567
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2J2	1.22e-03	57	69	3	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2J2	1.29e-03	58	69	3	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2J2	1.29e-03	58	69	3	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2J2	1.42e-03	60	69	3	IPR001128
Domain	AMP-bd_C	ACSM2A ACSM2B	1.76e-03	17	69	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	1.76e-03	17	69	2	PF13193
Domain	TUDOR	STK31 TDRD1	3.24e-03	23	69	2	PS50304
Domain	AMP-binding_CS	ACSM2A ACSM2B	4.13e-03	26	69	2	IPR020845
Domain	TUDOR	STK31 TDRD1	4.45e-03	27	69	2	SM00333
Domain	DnaJ_domain_CS	DNAJA2 DNAJC5	4.45e-03	27	69	2	IPR018253
Domain	AMP_BINDING	ACSM2A ACSM2B	4.78e-03	28	69	2	PS00455
Domain	AMP-binding	ACSM2A ACSM2B	5.47e-03	30	69	2	PF00501
Domain	Tudor	STK31 TDRD1	5.47e-03	30	69	2	IPR002999
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	5.47e-03	30	69	2	IPR000873
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2J2	4.40e-05	18	55	3	MM14841
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2J2	9.42e-05	23	55	3	M5372
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	9.78e-05	62	55	4	M39653
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2J2	1.22e-04	25	55	3	MM14846
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	2.22e-04	6	55	2	MM14693
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	3.10e-04	7	55	2	MM14598
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYP2A6 RANBP2 TLK1 ELOA2 DNAJC10 PCDHGB2 MRPS25 HSPH1 SMARCC1 BEND3 DNAJC5 EIF2AK4 STK31 HNRNPU BBOF1	2.14e-07	1442	72	15	35575683
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2G1P	2.96e-07	7	72	3	14630516
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	BLM RANBP2 HSPH1 SMARCC1 BEND3 DCLRE1A HNRNPU HDLBP	7.70e-07	357	72	8	37059091
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	2.15e-06	44	72	4	12745259
Pubmed	Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.	SHPRH RBM7 SMARCC1 BEND3	3.07e-06	48	72	4	22242598
Pubmed	Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.	CDKN1B RBL2 SMARCC1	3.80e-06	15	72	3	9891079
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	4.23e-06	2	72	2	16521160
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	4.23e-06	2	72	2	12325023
Pubmed	Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation.	DOCK1 ANKRD28	4.23e-06	2	72	2	19118547
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	4.23e-06	2	72	2	16636685
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	4.23e-06	2	72	2	2322567
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	4.23e-06	2	72	2	7864805
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	4.23e-06	2	72	2	19634011
Pubmed	Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939.	CDKN1B RANBP2	4.23e-06	2	72	2	28882106
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	4.23e-06	2	72	2	29948332
Pubmed	Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.	TRPC6 PDE5A	4.23e-06	2	72	2	20177073
Pubmed	p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.	CDKN1B RBL2	4.23e-06	2	72	2	16880527
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	1.27e-05	3	72	2	31645370
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	1.27e-05	3	72	2	11960914
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7	1.27e-05	3	72	2	3346244
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7	1.27e-05	3	72	2	2733794
Pubmed	Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus.	ACAT2 TNXB	1.27e-05	3	72	2	2475872
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	1.27e-05	3	72	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	1.27e-05	3	72	2	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7	1.27e-05	3	72	2	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	1.27e-05	3	72	2	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	1.27e-05	3	72	2	2703500
Pubmed	DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation.	CDKN1B DNAJC5	1.27e-05	3	72	2	33662413
Pubmed	Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.	CDKN1B RBL2	1.27e-05	3	72	2	17502351
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7	1.27e-05	3	72	2	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7	1.27e-05	3	72	2	24045421
Pubmed	pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance.	CDKN1B RBL2	1.27e-05	3	72	2	15161709
Pubmed	p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.	CDKN1B RBL2	1.27e-05	3	72	2	15867156
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7	1.27e-05	3	72	2	32987105
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	1.27e-05	3	72	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7	1.27e-05	3	72	2	2765478
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2G1P	1.27e-05	3	72	2	21252290
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7	1.27e-05	3	72	2	2415518
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	1.27e-05	3	72	2	22890016
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	1.27e-05	3	72	2	25710939
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	1.40e-05	70	72	4	15128046
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	BLM RANBP2 KALRN	1.67e-05	24	72	3	16620772
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	DNAJA2 HSPH1 ANKRD28 HNRNPU HDLBP	1.87e-05	156	72	5	32850835
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	DNAJC10 DNAJA2 HSPH1	1.89e-05	25	72	3	27483141
Pubmed	Inducible pRb2/p130 expression and growth-suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop.	CDKN1B RBL2	2.53e-05	4	72	2	10825149
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7	2.53e-05	4	72	2	9408084
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7	2.53e-05	4	72	2	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7	2.53e-05	4	72	2	1970547
Pubmed	DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.	DOCK1 DOCK5	2.53e-05	4	72	2	19004829
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7	2.53e-05	4	72	2	7565685
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	DOCK1 DOCK5	2.53e-05	4	72	2	23362269
Pubmed	The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.	DOCK1 DOCK5	2.53e-05	4	72	2	18820033
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	2.53e-05	4	72	2	32830538
Pubmed	Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.	TRPC6 PDE5A	2.53e-05	4	72	2	19961855
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	RANBP2 TLK1 HSPH1 SMARCC1 BEND3	3.52e-05	178	72	5	27637333
Pubmed	The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.	DOCK1 DOCK5	4.21e-05	5	72	2	24365888
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7	6.31e-05	6	72	2	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7	6.31e-05	6	72	2	8587134
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	RANBP2 PTPN23 VIRMA HNRNPU HDLBP	6.42e-05	202	72	5	24639526
Pubmed	A human MAP kinase interactome.	DOCK1 RANBP2 TLK1 DIAPH2 PTPN23 PRKCE HDLBP	6.71e-05	486	72	7	20936779
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BLM DNAJC10 HSPH1 SHPRH DIAPH2 ANKRD28 EIF2AK4	7.71e-05	497	72	7	36774506
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7	8.82e-05	7	72	2	9630227
Pubmed	Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.	CDKN1B RBL2	8.82e-05	7	72	2	10022926
Pubmed	Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.	CDKN1B RBL2	8.82e-05	7	72	2	9472014
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BLM RANBP2 ACAT2 DNAJA2 HSPH1 RBM7 SMARCC1 PTPN23 ANKRD28 HNRNPU HDLBP	1.01e-04	1353	72	11	29467282
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	DNAJA2 SMARCC1 BEND3 HNRNPU	1.01e-04	116	72	4	21549307
Pubmed	In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice.	CDKN1B RBL2	1.17e-04	8	72	2	28402854
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7	1.51e-04	9	72	2	37838304
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	RANBP2 DNAJA2 HSPH1 SHPRH HNRNPU	1.56e-04	244	72	5	30349055
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP2 KALRN DNAJA2 DIAPH2 SMARCC1 ANKRD28 PRKCE VIRMA HNRNPU	1.65e-04	963	72	9	28671696
Pubmed	G1 arrest and differentiation can occur independently of Rb family function.	CDKN1B RBL2	1.88e-04	10	72	2	21059851
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BLM CDKN1B RANBP2 TLK1 RBM7 SMARCC1 VIRMA HDLBP	1.98e-04	774	72	8	15302935
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	BLM DOCK1 DOCK5 RANBP2 RBM7 HNRNPU HDLBP	2.04e-04	582	72	7	20467437
Pubmed	Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.	DNAJA2 HSPH1	2.30e-04	11	72	2	24318877
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	CYP2A6 CYP2A7 DNAJC5	2.30e-04	57	72	3	17208939
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RANBP2 HSPH1 SMARCC1 ANKRD28	2.94e-04	153	72	4	26365490
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DIAPH2 SMARCC1 VIRMA HNRNPU	3.01e-04	154	72	4	16055720
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	BLM DOCK1 EVI5 EFCAB6 PGGHG ACAT2 TNMD TNXB ZNF345 HDLBP	3.21e-04	1293	72	10	15342556
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK1 DOCK5	3.25e-04	13	72	2	21930703
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	BLM CDKN1B SMARCC1	3.39e-04	65	72	3	27453043
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP2A6 CYP2J2	3.78e-04	14	72	2	19290787
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK1 DOCK5	3.78e-04	14	72	2	12432077
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	BLM RANBP2 DNAJC10 THYN1 KALRN RBM7 SMARCC1 TNXB HNRNPU	3.88e-04	1082	72	9	38697112
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK5 DNAJC10 DIAPH2 SMARCC1 ANKRD28 EIF2AK4 HNRNPU	3.97e-04	650	72	7	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BLM RANBP2 SMARCC1 BEND3 ANKRD28 VIRMA HDLBP	4.08e-04	653	72	7	22586326
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7	4.36e-04	15	72	2	29968852
Pubmed	JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.	RANBP2 ANKRD28	4.98e-04	16	72	2	26291670
Pubmed	Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?	SMARCC1 TDRD1	4.98e-04	16	72	2	16787967
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RANBP2 RBL2 HSPH1 HDLBP	5.31e-04	179	72	4	36261009
Pubmed	LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.	CDKN1B LGR6	5.63e-04	17	72	2	27559308
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7	5.63e-04	17	72	2	27197076
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	BLM DNAJC10 DNAJA2 HSPH1 SMARCC1 HNRNPU	5.64e-04	494	72	6	26831064
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	BLM DOCK1 RANBP2 KALRN HSPH1 RBM7	6.19e-04	503	72	6	16964243
Pubmed	The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.	CDKN1B RBL2	6.33e-04	18	72	2	15843406
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	MRPS25 DNAJA2 HSPH1 SMARCC1 HNRNPU	6.46e-04	333	72	5	36779763
Pubmed	Compensation by tumor suppressor genes during retinal development in mice and humans.	CDKN1B RBL2	7.06e-04	19	72	2	16672052
Pubmed	De novo variants in MPP5 cause global developmental delay and behavioral changes.	CDKN1B CRB1	7.06e-04	19	72	2	33073849
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	DNAJA2 HSPH1 RASGEF1C VIRMA	7.60e-04	197	72	4	20811636
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF229 ZNF222	7.84e-04	20	72	2	12743021
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7	7.84e-04	20	72	2	9890157
Interaction	TARS1 interactions	DNAJC10 DNAJA2 DNAJC5 EIF2AK4 DOT1L VIRMA HNRNPU	4.63e-06	195	69	7	int:TARS1
Cytoband	19q13.2	CYP2A6 CYP2A7 CYP2G1P ZNF222	1.34e-04	164	72	4	19q13.2
Cytoband	16p12.3	ACSM2A ACSM2B	1.32e-03	34	72	2	16p12.3
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2J2 CYP2G1P	2.15e-06	35	48	4	1001
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC10 DNAJA2 DNAJC5	2.97e-04	49	48	3	584
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	2.15e-03	26	48	2	40
GeneFamily	Tudor domain containing	STK31 TDRD1	4.33e-03	37	48	2	780
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500	DOCK1 SERPINB5 KALRN SHPRH PRKCE PDE5A CHSY3 HDLBP	5.37e-05	416	68	8	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	DOCK1 KALRN SHPRH PRKCE PDE5A HDLBP	5.57e-05	209	68	6	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN ACSM2A TNXB ACSM2B	1.32e-05	190	71	5	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 CYP2J2 MRPS25 CHSY3	1.36e-05	191	71	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN ACSM2A TNXB ACSM2B	1.39e-05	192	71	5	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Lpl_(Layer_2/3)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SERPINB5 TRPC6 RASGEF1C FGF17	1.43e-05	92	71	4	dfe63bb979f0382163955b32909ffab1de37685a
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-3\|TCGA-Thymus / Sample_Type by Project: Shred V9	CYP2A7 DNAJC10 PCDHGB2 CYP2G1P	2.24e-05	103	71	4	91fe062dcadd12fdb04fa4593a794c57f3f0411d
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DOCK1 KALRN PDE5A TDRD1	8.28e-05	144	71	4	1c001a5a3bbe4ecbce8305f8b260e933033550dd
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM GLOD5 ACSM2A ACSM2B	1.07e-04	154	71	4	89a60a79d07466d7ad05888d10a72d3b1ab384af
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM GLOD5 ACSM2A ACSM2B	1.07e-04	154	71	4	f1fea1a87e977221fa125b62287368be9af4987d
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM GLOD5 ACSM2A ACSM2B	1.07e-04	154	71	4	b5604c0b0b9b283352a3f612f40883b9123475d1
ToppCell	TCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal-1\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MGAM GLOD5 ACSM2A ACSM2B	1.07e-04	154	71	4	160b170a3ade8b246843c9854af332475c047ba0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.37e-04	164	71	4	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.37e-04	164	71	4	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.37e-04	164	71	4	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	KALRN ACSM2A TNXB ACSM2B	1.43e-04	166	71	4	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.57e-04	170	71	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	Ciliated_cells-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 SERPINB5 BBOF1	1.57e-04	170	71	4	3d3a03979014df3a05c49be18010c6b94d786707
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.57e-04	170	71	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.57e-04	170	71	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CHSY3 TDRD1 FGF17	1.60e-04	66	71	3	6cf03dd1db7607684cdcca7df08933f8cdc3adef
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nts_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CHSY3 TDRD1 FGF17	1.60e-04	66	71	3	85e0027bf0d4ebdcb6cac358aedd1d74aa83c612
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCDHGB2 ANKRD28 EIF2AK4 HDLBP	1.68e-04	173	71	4	09cd878c33534bd476d6a4880f5582076189da8c
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCDHGB2 ANKRD28 EIF2AK4 HDLBP	1.68e-04	173	71	4	62abaaaf48cabd1423f17fb27c33b75ea88867f4
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CHSY3 LGR6 TNXB TPCN1	1.68e-04	173	71	4	7e2149205e119cec4f5099c83c85d1e13470137a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.75e-04	175	71	4	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CYP2A6 CYP2A7 ACSM2A ACSM2B	1.75e-04	175	71	4	7f74961436f88c0e380819095e6104489914d765
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.75e-04	175	71	4	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	1.75e-04	175	71	4	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CYP2A6 CYP2A7 ACSM2A ACSM2B	1.75e-04	175	71	4	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM CDHR5 ACSM2A ACSM2B	1.79e-04	176	71	4	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN TRPC6 TNXB	1.83e-04	177	71	4	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN TRPC6 TNXB	1.83e-04	177	71	4	66ffa279147961080c104242a08b176e301d80e3
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN TRPC6 TNXB	1.83e-04	177	71	4	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 MRPS25 CHSY3	1.87e-04	178	71	4	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM ACSM2A ACSM2B TPCN1	1.91e-04	179	71	4	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN TNXB ACSM2B	1.91e-04	179	71	4	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-early_MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GLOD5 KALRN TRPC6 PDE5A	1.91e-04	179	71	4	d5b9c610c1519804b1753fed1b505293ea590867
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 ACSM2A ACSM2B TPCN1	1.95e-04	180	71	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.04e-04	182	71	4	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.04e-04	182	71	4	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	COPD-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	EVI5 ANKRD28 EIF2AK4 HDLBP	2.04e-04	182	71	4	19db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.04e-04	182	71	4	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 ACSM2A ACSM2B TPCN1	2.08e-04	183	71	4	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 ACSM2A ACSM2B TPCN1	2.08e-04	183	71	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM CDHR5 ACSM2A ACSM2B	2.08e-04	183	71	4	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 ACSM2A ACSM2B TPCN1	2.08e-04	183	71	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KALRN TRPC6 PDE5A DCLRE1A	2.08e-04	183	71	4	6cbc88c27dc957d182526e84824f70c8e860bf74
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM CDHR5 ACSM2A ACSM2B	2.12e-04	184	71	4	9434731f651820b05335085582960f08fbf895de
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DOCK5 KALRN TNXB ACSM2B	2.17e-04	185	71	4	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cck_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLOD5 STK31 FGF17	2.25e-04	74	71	3	7c77b7d84fd8d9d823bbfc586f2b95865e75ab0b
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cck_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLOD5 STK31 FGF17	2.25e-04	74	71	3	e008982158a3fbade8af9434eb32f20e00f92ba8
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLOD5 STK31 FGF17	2.25e-04	74	71	3	b4b961beb98ccf7551bb51773555615586da597d
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLOD5 STK31 FGF17	2.25e-04	74	71	3	ce00c59e0663093e33317227d31058a08db2d071
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM ACSM2A ACSM2B TPCN1	2.26e-04	187	71	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.26e-04	187	71	4	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.26e-04	187	71	4	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.26e-04	187	71	4	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM ACSM2A ACSM2B TPCN1	2.26e-04	187	71	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.40e-04	190	71	4	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDE5A CHSY3 LGR6	2.40e-04	190	71	4	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.40e-04	190	71	4	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 KALRN CHSY3 TNXB	2.40e-04	190	71	4	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PRKCE CDHR5 ACSM2A ACSM2B	2.40e-04	190	71	4	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINB5 ABCC8 TRPC6 PDE5A	2.45e-04	191	71	4	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	PBMC-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	CDKN1B RANBP2 ANKRD28 EIF2AK4	2.50e-04	192	71	4	41a7201febb7d88a39e4ee64df04cce18c691df8
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A6 CYP2A7 CYP2J2 MRPS25	2.55e-04	193	71	4	525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A6 CYP2A7 CYP2J2 MRPS25	2.55e-04	193	71	4	2d18f39615043dfbff120a00f6540ffa93082c83
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 CYP2J2 MRPS25	2.55e-04	193	71	4	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Megakaryocyte\|World / Lineage, cell class and subclass	KALRN TRPC6 PDE5A DCLRE1A	2.55e-04	193	71	4	352cd442b6e62f09b6d22a139774067873644594
ToppCell	10x3'2.3-week_12-13-Hematopoietic-MK-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KALRN TRPC6 PDE5A DCLRE1A	2.55e-04	193	71	4	3d4411b3c1cb160dec5db29f0c126d8827dfe185
ToppCell	Goblet\|World / shred by cell class for turbinate	CYP2A6 DNAJC10 B4GAT1 CYP2J2	2.60e-04	194	71	4	03b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 MRPS25 CHSY3	2.65e-04	195	71	4	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDE5A CHSY3 TNXB	2.70e-04	196	71	4	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM CDHR5 ACSM2A ACSM2B	2.70e-04	196	71	4	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDE5A CHSY3 TNXB	2.70e-04	196	71	4	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	COVID-19-kidney-PCT-S3-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CDHR5 ACSM2A ACSM2B BBOF1	2.81e-04	198	71	4	36a60397f49f5381ae377155b73e1891448846b7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2A6 CYP2J2 MRPS25 CHSY3	2.81e-04	198	71	4	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	normal_Lung-Epithelial_cells-Club\|Epithelial_cells / Location, Cell class and cell subclass	CYP2A6 CYP2A7 CYP2J2 MRPS25	2.81e-04	198	71	4	a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MGAM ABCC8 MGARP	2.84e-04	80	71	3	3413ac5e1c1e59eab6a83b889b870a8db4efccb9
ToppCell	T_cells-CCR7+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CDKN1B RANBP2 HSPH1 HNRNPU	2.86e-04	199	71	4	467820d6abe3024d9d655b9672c2f9cdc1303db3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM CDHR5 ACSM2A ACSM2B	2.92e-04	200	71	4	825aad08431dd6b54aa636ace6efc821dfaf8014
ToppCell	PBMC-Severe-cDC_1\|Severe / Compartment, Disease Groups and Clusters	BEND3 TPCN1 BBOF1	2.94e-04	81	71	3	6d1e524f000b71c935359afc801a1d31f218fec8
Drug	AC1NUTWC	MGAM ACSM2A ACSM2B	1.21e-07	4	72	3	CID005460914
Drug	etioporphyrin	BLM MGAM	9.86e-06	2	72	2	CID000079013
Drug	AC1L1BEQ	CDKN1B CYP2A6 CYP2A7 CYP2J2 TRPC6	1.15e-05	93	72	5	CID000001407
Drug	hygromycin A	BLM MGAM RANBP2 ACAT2 PRKCE	1.64e-05	100	72	5	CID006433481
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7 CYP2G1P	2.77e-06	12	70	3	EFO_0007794
Disease	X-21319 measurement	ACSM2A ACSM2B	5.55e-06	2	70	2	EFO_0800807
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7 CYP2G1P	1.21e-05	19	70	3	EFO_0007872
Disease	X-11478 measurement	ACSM2A ACSM2B	1.66e-05	3	70	2	EFO_0021242
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	5.52e-05	5	70	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	8.27e-05	6	70	2	EFO_0800106
Disease	Colorectal Carcinoma	CYP2A6 SERPINB5 ELOA2 KALRN ABCC8 PRKCE LGR6 ZNF572	2.54e-04	702	70	8	C0009402
Disease	pre-eclampsia (implicated_via_orthology)	CYP2J2 PDE5A	4.25e-04	13	70	2	DOID:10591 (implicated_via_orthology)
Disease	Colorectal Neoplasms	CYP2A6 SERPINB5 ABCC8 PRKCE LGR6	5.17e-04	277	70	5	C0009404
Disease	nephrotic syndrome	KALRN TNXB ZNF345	6.51e-04	71	70	3	EFO_0004255
Disease	urinary albumin to creatinine ratio	MGAM CYP2A6 CYP2A7 CYP2G1P	8.79e-04	179	70	4	EFO_0007778
Disease	alpha-tocopherol measurement	PRKCE RNF215	1.03e-03	20	70	2	EFO_0007898
Disease	urinary uromodulin measurement	ACSM2A FGF17 ACSM2B	1.56e-03	96	70	3	EFO_0005663

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNFEKNENKLPPHES	TDRD1	26	Q9BXT4
FNPQHFLNEKGQFKK	CYP2A6	411	P11509
KFPEDFDDGEHAKQK	EIF2AK4	961	Q9P2K8
KEENGQPFDPHFKIN	CYP2J2	171	P51589
FNPDHFLENGQFKKR	CYP2J2	421	P51589
FKEALKFHPQKEAEN	B4GAT1	376	O43505
GHQEVPAKFNFASDV	ACSM2A	36	Q08AH3
NQKNEKGFTPLHFAA	ANKRD28	266	O15084
NNFAFGPEVDHQLKE	DOT1L	241	Q8TEK3
NFDFQNHKPLEGKYE	CDKN1B	61	P46527
QGFDNQAFLPDHKAN	CDHR5	711	Q9HBB8
KKFPQAENQHDKFVE	DIAPH2	931	O60879
NELEGQFHQKAKEIG	BBOF1	126	Q8ND07
GQLPFPNHAEKQKQF	FGF17	181	O60258
PNHAEKQKQFEFVGS	FGF17	186	O60258
EQGFKFGHVDQENSP	RANBP2	1856	P49792
EAGDFHFQPAVKKFV	PTPN23	16	Q9H3S7
NPNFKGLSEDFHAKD	RBL2	251	Q08999
EQVDPGHFLDNKDQE	BEND3	361	Q5T5X7
RNHCFQDFKEEKPQE	ELOA2	586	Q8IYF1
ELGFHNNNIKAIPEK	LGR6	261	Q9HBX8
GDQKFNLHEVGKEFE	GLOD5	76	A6NK44
QNGEDAIKQHPFFKE	PRKCE	656	Q02156
KGFPEFVNELHNNGQ	MGAM	431	O43451
HGRAFNDPFIQKEKE	HSPH1	71	Q92598
EQVKHFFNLNEKTGE	PCDHGB2	286	Q9Y5G2
KNQFNLEDPHQKELF	PDE5A	741	O76074
PEHNFFKEKDSLGQE	EVI5	211	O60447
HNCAVEFNFGQKEKP	HNRNPU	451	Q00839
EYHQPGDKFEASKQN	KALRN	2301	O60229
ADKIKVPFDVEQNFH	PGGHG	471	Q32M88
PGLEEDQKKNKHEDF	PRDM12	216	Q9H4Q4
PEAADKFKEINNAHA	DNAJC5	51	Q9H3Z4
HPDKNPNAGDKFKEI	DNAJA2	36	O60884
VKDFFKNAPAGQETQ	BLM	86	P54132
IINPQFKEEGNKHEN	CASD1	106	Q96PB1
FKEEGNKHENIPFED	CASD1	111	Q96PB1
INGKVDDEDKQHFIP	DOCK1	336	Q14185
KVDDEEKQHFIPFQQ	DOCK5	336	Q9H7D0
FSKEPNGKINVHDFK	EFCAB6	646	Q5THR3
FNPQHFLDDKGQFKK	CYP2A7	411	P20853
GHQEENKNDFIPDLA	CENPJ	116	Q9HC77
KAEIHPFQGEKENVA	MGARP	86	Q8TDB4
DEPEFHSAQSNKQKQ	DCLRE1A	431	Q6PJP8
FHFGKNENSNDPELK	DNAJC10	371	Q8IXB1
ENVHGFINKPQEEQF	CRB1	1111	P82279
KPCFGKKNDGENQEH	SLC13A4	431	Q9UKG4
PGQSLQHKENFFVFK	OR1E3	301	Q8WZA6
EEEEKKQLSHPANFG	MRPS25	116	P82663
DGKPKQFAFVNFKHE	RBM7	46	Q9Y580
VGKEQAAQFHQENKG	RNF215	116	Q9Y6U7
VKKDGFLQPHFLAEQ	SHPRH	751	Q149N8
QVLHFENVKDVPFGF	SERPINB5	56	P36952
FPEEEFDGHQFQKAQ	IFNA4	61	P05014
QFQEDAFGKHVTNPA	SMARCC1	86	Q92922
HLGKENDVFQPKTQF	ABCC8	326	Q09428
GHQEVPAKFNFASDV	ACSM2B	36	Q68CK6
QHFLDEQGRFKKNEA	CYP2G1P	66	Q6ZSU1
KEDQQLGVIPSFNHF	CHSY3	441	Q70JA7
GNFIAKEEEKPNHQE	ZNF572	96	Q7Z3I7
NKDGIPKVDQFHLDD	STK31	931	Q9BXU1
LHFPANEKKGIEQNE	TNMD	206	Q9H2S6
KRINNEDNSQFKDHP	TLK1	436	Q9UKI8
NAQKAGHFDKEIVPV	ACAT2	191	Q9BWD1
PNGHVNFEKFLELAK	RASGEF1C	386	Q8N431
VPEGQFDHFLVQFKN	TNXB	2216	P22105
LQGKDFQFSEDAAPH	ZNF229	126	Q9UJW7
GENNDKFFTHPKDAK	TPCN1	81	Q9ULQ1
KEAYPDHTQFEKNNP	THYN1	131	Q9P016
HPKDFSGKDNEEVKQ	TRAPPC8	781	Q9Y2L5
GKHYPEDQKQQQDPF	ZNF875	151	P10072
EHDVNIQFPDKDDGN	HDLBP	1081	Q00341
KNQFERKQGSQEGHF	ZNF345	21	Q14585
ELFQGHKKGFQEDAE	TRPC6	786	Q9Y210
KRNPKHADGEKEDQF	VIRMA	156	Q69YN4
HTREKPFQGENCKQF	ZNF222	111	Q9UK12