Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ISG15 transferase activity	UBE2E1 UBE2E2	1.63e-04	4	105	2	GO:0042296
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	NLRP11 MOXD1	2.71e-04	5	105	2	GO:0016715
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	1.02e-05	9	104	3	GO:0160063
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	1.13e-05	9	109	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	4.81e-05	14	109	3	GO:0072379
Domain	NACHT	NLRP11 NLRP1 NLRP14 NLRC5 NLRP8	1.44e-07	23	103	5	PS50837
Domain	NACHT_NTPase	NLRP11 NLRP1 NLRP14 NLRC5 NLRP8	1.44e-07	23	103	5	IPR007111
Domain	-	NLRP11 FLII PRAMEF20 NLRP1 LRRK1 FBXL21P NLRP14 LRRCC1 NLRC5 LRRC8B DNAAF1 NLRP8	2.05e-07	321	103	12	3.80.10.10
Domain	L_dom-like	NLRP11 FLII PRAMEF20 NLRP1 LRRK1 FBXL21P NLRP14 LRRCC1 NLRC5 LRRC8B DNAAF1 NLRP8	2.58e-07	328	103	12	IPR032675
Domain	DUF2012	NOMO1 NOMO2 NOMO3	6.49e-07	4	103	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	6.49e-07	4	103	3	IPR019008
Domain	ARM-like	KPNA5 SETX NEK10 CIP2A AP3B1 NBEAL2 ANKAR ULK4 MMS19 HEATR3	2.44e-06	270	103	10	IPR011989
Domain	Leu-rich_rpt	NLRP11 FLII NLRP1 LRRK1 NLRP14 LRRCC1 NLRC5 LRRC8B DNAAF1 NLRP8	2.53e-06	271	103	10	IPR001611
Domain	DAPIN	NLRP11 NLRP1 NLRP14 NLRP8	5.91e-06	22	103	4	PS50824
Domain	PYRIN	NLRP11 NLRP1 NLRP14 NLRP8	5.91e-06	22	103	4	PF02758
Domain	DAPIN	NLRP11 NLRP1 NLRP14 NLRP8	5.91e-06	22	103	4	IPR004020
Domain	PYRIN	NLRP11 NLRP1 NLRP14 NLRP8	5.91e-06	22	103	4	SM01289
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	8.94e-06	8	103	3	IPR013784
Domain	LRR_6	NLRP11 NLRP1 NLRP14 NLRC5 NLRP8	1.29e-05	55	103	5	PF13516
Domain	ARM-type_fold	KPNA5 NEK10 CIP2A AP3B1 LYST NBEAL2 ANKAR ULK4 MMS19 HEATR3	1.80e-05	339	103	10	IPR016024
Domain	LIMR	LMBR1 LMBR1L	3.01e-05	2	103	2	IPR008075
Domain	-	KPNA5 NEK10 CIP2A AP3B1 ANKAR ULK4 MMS19 HEATR3	3.17e-05	222	103	8	1.25.10.10
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	4.48e-05	13	103	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	4.48e-05	13	103	3	2.60.40.1120
Domain	ANK	POTEB3 POTED RIPK4 LRRK1 POTEC ANKAR HACE1 TRPV5	7.54e-05	251	103	8	SM00248
Domain	ANK_REPEAT	POTEB3 POTED RIPK4 LRRK1 POTEC ANKAR HACE1 TRPV5	7.96e-05	253	103	8	PS50088
Domain	ANK_REP_REGION	POTEB3 POTED RIPK4 LRRK1 POTEC ANKAR HACE1 TRPV5	8.19e-05	254	103	8	PS50297
Domain	Ankyrin_rpt	POTEB3 POTED RIPK4 LRRK1 POTEC ANKAR HACE1 TRPV5	1.02e-04	262	103	8	IPR002110
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	1.05e-04	17	103	3	IPR008969
Domain	LRR	FLII NLRP1 LRRK1 LRRCC1 NLRC5 LRRC8B DNAAF1	1.25e-04	201	103	7	PS51450
Domain	LMBR1	LMBR1 LMBR1L	1.79e-04	4	103	2	PF04791
Domain	LMBR1-like_membr_prot	LMBR1 LMBR1L	1.79e-04	4	103	2	IPR006876
Domain	LRR_1	FLII NLRP1 LRRK1 LRRCC1 NLRC5 LRRC8B DNAAF1	2.12e-04	219	103	7	PF00560
Domain	DEATH-like_dom	NLRP11 NLRP1 MADD NLRP14 NLRP8	2.19e-04	99	103	5	IPR011029
Domain	PH_BEACH	LYST NBEAL2	4.45e-04	6	103	2	PF14844
Domain	PH-BEACH_dom	LYST NBEAL2	8.25e-04	8	103	2	IPR023362
Domain	-	LYST NBEAL2	8.25e-04	8	103	2	2.30.29.40
Domain	PH_BEACH	LYST NBEAL2	8.25e-04	8	103	2	PS51783
Domain	BEACH_dom	LYST NBEAL2	1.06e-03	9	103	2	IPR000409
Domain	BEACH	LYST NBEAL2	1.06e-03	9	103	2	PS50197
Domain	Beach	LYST NBEAL2	1.06e-03	9	103	2	PF02138
Domain	-	LYST NBEAL2	1.06e-03	9	103	2	1.10.1540.10
Domain	Beach	LYST NBEAL2	1.06e-03	9	103	2	SM01026
Domain	Ank_2	POTEB3 LRRK1 POTEC ANKAR HACE1 TRPV5	1.23e-03	215	103	6	PF12796
Domain	Leu-rich_rpt_4	FLII NLRC5	1.32e-03	10	103	2	IPR025875
Domain	LRR_4	FLII NLRC5	1.32e-03	10	103	2	PF12799
Domain	ARM_REPEAT	KPNA5 NEK10 ANKAR	1.39e-03	40	103	3	PS50176
Domain	Ank	POTED RIPK4 LRRK1 POTEC HACE1 TRPV5	1.66e-03	228	103	6	PF00023
Domain	-	NLRP11 NLRP1 NLRP14 NLRP8	1.75e-03	93	103	4	1.10.533.10
Domain	PROTEIN_KINASE_TYR	FLT1 NEK10 PRAG1 TIE1	2.04e-03	97	103	4	PS00109
Domain	Tyr_kinase_AS	FLT1 NEK10 PRAG1 TIE1	2.04e-03	97	103	4	IPR008266
Domain	-	POTEB3 LRRK1 POTEC ANKAR HACE1 TRPV5	2.52e-03	248	103	6	1.25.40.20
Domain	Myotubularin-like_Pase_dom	MTMR12 SBF2	2.62e-03	14	103	2	IPR010569
Domain	uDENN	MADD SBF2	2.62e-03	14	103	2	SM00800
Domain	PPASE_MYOTUBULARIN	MTMR12 SBF2	2.62e-03	14	103	2	PS51339
Domain	Myotubularin_fam	MTMR12 SBF2	2.62e-03	14	103	2	IPR030564
Domain	Myotub-related	MTMR12 SBF2	2.62e-03	14	103	2	PF06602
Domain	Ankyrin_rpt-contain_dom	POTEB3 LRRK1 POTEC ANKAR HACE1 TRPV5	2.84e-03	254	103	6	IPR020683
Domain	uDENN	MADD SBF2	3.02e-03	15	103	2	PF03456
Domain	UDENN	MADD SBF2	3.44e-03	16	103	2	PS50946
Domain	DDENN	MADD SBF2	3.44e-03	16	103	2	PS50947
Domain	DENN	MADD SBF2	3.44e-03	16	103	2	SM00799
Domain	dDENN	MADD SBF2	3.44e-03	16	103	2	SM00801
Domain	DENN	MADD SBF2	3.44e-03	16	103	2	PF02141
Domain	dDENN_dom	MADD SBF2	3.44e-03	16	103	2	IPR005112
Domain	uDENN_dom	MADD SBF2	3.44e-03	16	103	2	IPR005113
Domain	dDENN	MADD SBF2	3.44e-03	16	103	2	PF03455
Domain	DENN	MADD SBF2	3.44e-03	16	103	2	PS50211
Domain	DENN_dom	MADD SBF2	3.44e-03	16	103	2	IPR001194
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	3.08e-08	3	110	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	3.08e-08	3	110	3	25576386
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP11 NLRP1 NLRP14 NLRP8	9.25e-08	14	110	4	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP11 NLRP1 NLRP14 NLRP8	9.25e-08	14	110	4	12563287
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	1.23e-07	4	110	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	1.23e-07	4	110	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	1.70e-06	8	110	3	15257293
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB3 POTED POTEC	1.70e-06	8	110	3	12475935
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	2.55e-06	9	110	3	36261522
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	HSP90B2P NOMO1 NOMO2 NOMO3	2.79e-06	31	110	4	19136429
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	4.99e-06	11	110	3	32820719
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	MTMR12 MIA3 SETX CEP85 OGT ELP1 AP3B1 ZZEF1 MADD OSBPL10 HEATR3	7.15e-06	650	110	11	38777146
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	NLRP1 LRRK1 LRRC8B PAK1IP1	7.93e-06	40	110	4	25011449
Pubmed	Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl.	AP3B1 LYST	9.91e-06	2	110	2	3584547
Pubmed	Characterization of a novel human gene containing ANK repeats and ARM domains.	OSGEPL1 ANKAR	9.91e-06	2	110	2	15110750
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII PDE2A LRRK1 FHIP1B ZZEF1 PRAG1 LYST MADD TLNRD1 NBEAL2 SBF2 NLRC5 PDCD11 ULK4	1.06e-05	1105	110	14	35748872
Pubmed	Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.	LMBR1 LMBR1L	2.97e-05	3	110	2	19136951
Pubmed	Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.	ADCY5 MADD	2.97e-05	3	110	2	21887289
Pubmed	Motor dysfunction in type 5 adenylyl cyclase-null mice.	DRD1 ADCY5	2.97e-05	3	110	2	12665504
Pubmed	LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolism.	LMBR1 LMBR1L	2.97e-05	3	110	2	20446115
Pubmed	Role of Flightless-I (Drosophila) homolog in the transcription activation of type I collagen gene mediated by transforming growth factor beta.	FLII COL1A2	2.97e-05	3	110	2	25451260
Pubmed	Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.	FLT1 ELP1 TIE1	3.93e-05	21	110	3	19015235
Pubmed	Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.	FLT1 TIE1	5.92e-05	4	110	2	20164029
Pubmed	The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome.	AP3B1 LYST	5.92e-05	4	110	2	23043085
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	DRD1 ADCY5	5.92e-05	4	110	2	25049074
Pubmed	Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.	DRD1 ADCY5	5.92e-05	4	110	2	12223546
Pubmed	A molecular and genetic analysis of renalglomerular capillary development.	FLT1 TIE1	5.92e-05	4	110	2	14517396
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	TRIM11 UBE2E1 UBE2E2	8.52e-05	27	110	3	21143188
Pubmed	Sandy: a new mouse model for platelet storage pool deficiency.	AP3B1 LYST	9.85e-05	5	110	2	1936982
Pubmed	Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population.	OSGEPL1 ANKAR	9.85e-05	5	110	2	25162662
Pubmed	Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse.	AP3B1 LYST	9.85e-05	5	110	2	8830098
Pubmed	A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.	AP3B1 LPA	9.85e-05	5	110	2	17569884
Pubmed	Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.	NLRP11 NLRC5	9.85e-05	5	110	2	12615073
Pubmed	RING E3-Catalyzed E2 Self-Ubiquitination Attenuates the Activity of Ube2E Ubiquitin-Conjugating Enzymes.	UBE2E1 UBE2E2	9.85e-05	5	110	2	25960396
Pubmed	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.	UBE2E1 UBE2E2	9.85e-05	5	110	2	16428300
Pubmed	Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development.	FLT1 TIE1	9.85e-05	5	110	2	7647376
Pubmed	The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.	CEP85 NEK10 TRIM11 ASCC2	1.37e-04	82	110	4	25260751
Pubmed	Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.	UBE2E1 UBE2E2	1.47e-04	6	110	2	30349006
Pubmed	Muted, a new mutant affecting coat colour and otoliths of the mouse, and its position in linkage group XIV.	AP3B1 LYST	1.47e-04	6	110	2	5367369
Pubmed	The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.	UBE2E1 UBE2E2	1.47e-04	6	110	2	20484052
Pubmed	Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes.	UBE2E1 UBE2E2	1.47e-04	6	110	2	11274149
Pubmed	A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.	FGF17 PAK1IP1	1.47e-04	6	110	2	23935987
Pubmed	Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.	DRD1 LRRK1	1.47e-04	6	110	2	23675505
Pubmed	Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.	FLT1 TIE1	1.47e-04	6	110	2	7596436
Pubmed	N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.	UBE2E1 UBE2E2	1.47e-04	6	110	2	11322894
Pubmed	The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3.	NLRP1 TRIM11	1.47e-04	6	110	2	34512673
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO1 NOMO2 NOMO3	1.57e-04	33	110	3	30783098
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MTMR12 MADD SBF2 TARBP2 COL1A2	1.96e-04	167	110	5	25659891
Pubmed	Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.	POTEB3 POTED	2.06e-04	7	110	2	15276201
Pubmed	Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.	FLT1 TIE1	2.06e-04	7	110	2	11566878
Pubmed	Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes.	UBE2E1 UBE2E2	2.06e-04	7	110	2	18615712
Pubmed	Dicer is required for embryonic angiogenesis during mouse development.	FLT1 TIE1	2.06e-04	7	110	2	15613470
Pubmed	Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity.	UBE2E1 UBE2E2	2.06e-04	7	110	2	31028095
Pubmed	Elongator and codon bias regulate protein levels in mammalian peripheral neurons.	SETX ELP1	2.06e-04	7	110	2	29497044
Pubmed	Linkage of loci associated with two pigment mutations on mouse chromosome 13.	AP3B1 LYST	2.06e-04	7	110	2	1682216
Pubmed	Molecular markers near two mouse chromosome 13 genes, muted and pearl, which cause platelet storage pool deficiency (SPD).	DRD1 AP3B1	2.06e-04	7	110	2	7719021
Pubmed	Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice.	FLT1 TIE1	2.06e-04	7	110	2	10027415
Pubmed	The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.	OGT NOMO1 NOMO3	2.21e-04	37	110	3	8076819
Pubmed	E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.	UBE2E1 UBE2E2	2.74e-04	8	110	2	17873885
Pubmed	The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.	UBE2E1 UBE2E2	2.74e-04	8	110	2	28972136
Pubmed	Role of vascular endothelial-cadherin in vascular morphogenesis.	FLT1 TIE1	2.74e-04	8	110	2	10207135
Pubmed	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	UBE2E1 UBE2E2	2.74e-04	8	110	2	24446487
Pubmed	Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.	FLT1 HACE1	2.74e-04	8	110	2	20600704
Pubmed	Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.	FLT1 TIE1	2.74e-04	8	110	2	15644447
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ADGRG5 MIA3 GPR78 FGF17 MOXD1 EYS MANSC1 LMBR1L CD163L1 NBEAL2 LRRC8B	2.96e-04	985	110	11	12975309
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MTMR12 FHIP1B SBF2 LRRCC1	3.17e-04	102	110	4	11214970
Pubmed	In vitro selection of Jun-associated proteins using mRNA display.	MIA3 LRRCC1	3.52e-04	9	110	2	15576676
Pubmed	Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.	UBE2E1 UBE2E2	3.52e-04	9	110	2	15545318
Pubmed	Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome.	AP3B1 LYST	3.52e-04	9	110	2	10193444
Pubmed	Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.	UBE2E1 UBE2E2	3.52e-04	9	110	2	32049508
Pubmed	Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses.	FLT1 TIE1	3.52e-04	9	110	2	19881219
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	LMBR1 RIPK4 MADD PDCD11 RNF139 NOMO3	3.69e-04	296	110	6	34186245
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	NOMO1 NOMO2 SBF2 NOMO3	4.23e-04	110	110	4	27889896
Pubmed	The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF.	FLT1 TIE1	4.39e-04	10	110	2	10395786
Pubmed	E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.	UBE2E1 UBE2E2	4.39e-04	10	110	2	21518764
Pubmed	Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.	FLT1 TIE1	4.39e-04	10	110	2	7596435
Pubmed	ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression.	FLT1 TIE1	4.39e-04	10	110	2	12221099
Pubmed	Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.	ITGA8 TRPV5 COL1A2	4.51e-04	47	110	3	28527294
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MTMR12 MIA3 CEP85 CIP2A ELP1 AP3B1 MADD PHKB TRIM11 SBF2 COL1A2	5.02e-04	1049	110	11	27880917
Pubmed	RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.	UBE2E1 RNF139	5.35e-04	11	110	2	10500182
Pubmed	Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.	UBE2E1 UBE2E2	5.35e-04	11	110	2	19712108
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	NLRC5 MMS19	5.35e-04	11	110	2	37279268
Pubmed	E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.	UBE2E1 UBE2E2	6.41e-04	12	110	2	22069333
Pubmed	Requirement of the MADS-box transcription factor MEF2C for vascular development.	FLT1 TIE1	6.41e-04	12	110	2	9778514
Pubmed	Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.	ADCY5 MADD	6.41e-04	12	110	2	20419449
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP14 NLRP8	6.41e-04	12	110	2	12766759
Pubmed	Cbl interacts with multiple E2s in vitro and in cells.	UBE2E1 UBE2E2	7.56e-04	13	110	2	31120930
Pubmed	Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.	MIA3 COL1A2	7.56e-04	13	110	2	11839810
Pubmed	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	TEPSIN FHIP1B	7.56e-04	13	110	2	32073997
Pubmed	The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.	FLT1 TIE1	7.56e-04	13	110	2	10675351
Pubmed	FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.	FLT1 COL1A2	7.56e-04	13	110	2	17014841
Pubmed	Skeletal myogenic progenitors in the endothelium of lung and yolk sac.	FLT1 TIE1	7.56e-04	13	110	2	14567980
Pubmed	Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.	FLT1 TIE1	7.56e-04	13	110	2	28835631
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	KPNA5 MTMR12 CIP2A ELP1 NOMO1 PHKB TRIM11 LMBR1L TARBP2 HEATR3	7.57e-04	931	110	10	27432908
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MIA3 CIP2A ELP1 LMBR1 SLC35B2 AP3B1 LMBR1L MMS19 HEATR3 NOMO3	8.28e-04	942	110	10	31073040
Pubmed	Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling.	TIE1 COL1A2	8.80e-04	14	110	2	31319059
Pubmed	Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.	UBE2E1 UBE2E2	8.80e-04	14	110	2	36481767
Pubmed	Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.	FLT1 TIE1	8.80e-04	14	110	2	10981960
Pubmed	Mutations in mice that influence natural killer (NK) cell activity.	AP3B1 LYST	8.80e-04	14	110	2	6971254
Pubmed	Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.	UBE2E1 UBE2E2	1.01e-03	15	110	2	21628527
Interaction	POTED interactions	POTEB3 POTED POTEC	5.17e-07	4	103	3	int:POTED
GeneFamily	NLR family	NLRP11 NLRP1 NLRP14 NLRC5 NLRP8	2.79e-08	25	66	5	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP11 NLRP1 NLRP14 NLRP8	1.93e-06	25	66	4	994
GeneFamily	Ankyrin repeat domain containing	POTED RIPK4 POTEC ANKAR HACE1 TRPV5	2.51e-04	242	66	6	403
GeneFamily	WD repeat domain containing\|BEACH domain containing	LYST NBEAL2	4.65e-04	9	66	2	1230
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTED POTEC	9.97e-04	13	66	2	685
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR12 SBF2	1.34e-03	15	66	2	903
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	MADD SBF2	3.73e-03	25	66	2	504
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d10.LisOva, CD8+ CD45.1+, Spleen, avg-3	ADGRG5 PDE2A ZNF683 GSAP FHIP1B PRAG1 TMEM71 MADD NBEAL2 NLRC5	6.66e-06	369	96	10	GSM605891_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d15.LisOva, CD8+ CD45.1+, Spleen, avg-3	ADGRG5 PDE2A ZNF683 GSAP FHIP1B PRAG1 TMEM71 NBEAL2 NLRC5	5.20e-05	376	96	9	GSM605894_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d8.VSVOva, CD8+ CD45.1+, Spleen, avg-3	PDE2A OGT FHIP1B PRAG1 TMEM71 LYST MADD NBEAL2 NLRC5	6.49e-05	387	96	9	GSM538392_500
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT1 PDE2A TLNRD1 KLHL5 MOXD1 TIE1	6.96e-06	188	109	6	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	LRRK1 TSPAN33 TMEM156 KLHL5 UBE2E2 OSBPL10	7.40e-06	190	109	6	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 KLHL5 TIE1	8.33e-06	194	109	6	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 KLHL5 TIE1	8.83e-06	196	109	6	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 MOXD1 SBF2 COL1A2	8.83e-06	196	109	6	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 KLHL5 TIE1	8.83e-06	196	109	6	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 KLHL5 TIE1	9.36e-06	198	109	6	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	distal-Hematologic-EREG+_Dendritic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE2A ZZEF1 SLC40A1 CD163L1 DNAAF1 HEATR3	9.91e-06	200	109	6	7809c74a2e52768854b66a135522138281bc4449
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Nxph1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DRD1 RIPK4 MOXD1 NBEAL2 ULK4	1.26e-05	122	109	5	dba1c647172a11381efcb178a23808161908daa3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FHIP1B ADCY5 CFAP54 ULK4 NLRP8	2.71e-05	143	109	5	7a7a9829ba63468c9745904d9e993590051207ab
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG5 CIP2A LRRK1 NLRP14 MOG	3.41e-05	150	109	5	8b781ec3e6c2adf052d46d724e2aef72b0c27d13
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG5 CIP2A LRRK1 NLRP14 MOG	3.41e-05	150	109	5	17da17f01a3d41ac7df20f806e3eae30eca06982
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG5 CIP2A LRRK1 NLRP14 MOG	3.41e-05	150	109	5	8702d5bb419d5e997d388e8f7e0365ba5d1de8d5
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KCNH7 NLRP1 GSAP PTAFR DISP3	3.63e-05	152	109	5	931c10245cde9b3290224cc1da46b2bf300b9ac2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 ITGA8 NLRP1 TLNRD1 NLRC5	4.50e-05	159	109	5	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TEPSIN TSPAN33 SBF2 HACE1 TARBP2	5.06e-05	163	109	5	63b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TEPSIN TSPAN33 SBF2 HACE1 TARBP2	6.53e-05	172	109	5	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	OGT LRRK1 TMEM156 CFAP54 NLRP14	7.08e-05	175	109	5	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	Adult-Immune-B_cell\|Adult / Lineage, Cell type, age group and donor	ADGRG5 ITGA8 LRRK1 TMEM156 OSBPL10	7.28e-05	176	109	5	4aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 KLHL5 TIE1	7.88e-05	179	109	5	8f9e538c822940785130297712b75131812a4603
ToppCell	droplet-Fat-Gat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 PDE2A PRAG1 TIE1 NBEAL2	7.88e-05	179	109	5	08cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCell	Children_(3_yrs)-Immune-B_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRG5 PRAG1 TMEM156 OSBPL10 NLRC5	8.09e-05	180	109	5	40a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell	Pericytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	DRD1 ITGA8 ADCY5 CARNS1 COL1A2	8.30e-05	181	109	5	ff445a8e56522e57e27405184d123cf905caf8cc
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	ITGA8 LRRK1 CFAP54 UBE2E2 DNAAF1	9.44e-05	186	109	5	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	9.68e-05	187	109	5	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 PDE2A KLHL5 MOXD1 TIE1	9.68e-05	187	109	5	6cf7be5401b81a4eeb30840fb3733d61a24af539
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	LRRK1 TSPAN33 TMEM156 UBE2E2 OSBPL10	9.68e-05	187	109	5	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CIP2A ZNF683 CCDC88B TMEM71 SLC35G4	9.68e-05	187	109	5	73931a5ea73799095daff100b5f18853c57c74dc
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 PDE2A KLHL5 MOXD1 TIE1	9.68e-05	187	109	5	63834420db930df91b62494c9d7aaa9a25bca530
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 PDE2A TLNRD1 MANSC1 TIE1	1.02e-04	189	109	5	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	LRRK1 TSPAN33 TMEM156 PHKB OSBPL10	1.02e-04	189	109	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PTAFR SLC40A1 TSPAN33 CD163L1 MOG	1.04e-04	190	109	5	cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.07e-04	191	109	5	f663131a4810584c5854bd64ee7991a237b7707f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.10e-04	192	109	5	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM156 MOXD1 LMBR1L ANKAR	1.11e-04	101	109	4	86acaa2502f61baa714ae988b73e3e73a71e897e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 MOXD1 COL1A2	1.12e-04	193	109	5	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLT1 KCNH7 SLC40A1 MOXD1 COL1A2	1.12e-04	193	109	5	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	COPD-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	ADGRG5 GSAP TMEM71 LYST MADD	1.12e-04	193	109	5	0020249fa71afb500af73700543bb6f349be6b10
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.12e-04	193	109	5	52e918884877b6659cdca0496390e440f73694a9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.15e-04	194	109	5	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.15e-04	194	109	5	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.15e-04	194	109	5	e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.15e-04	194	109	5	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ITGA8 SLC40A1 MOXD1 SBF2 COL1A2	1.18e-04	195	109	5	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.18e-04	195	109	5	23ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCell	distal-Hematologic-Plasma-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGA8 NOMO1 TMEM156 MOXD1 CARNS1	1.21e-04	196	109	5	8201aded3c7109fae5e6ca12bac2076acc7bf070
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.21e-04	196	109	5	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.21e-04	196	109	5	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.21e-04	196	109	5	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 SBF2 COL1A2	1.24e-04	197	109	5	31a1852911bda38543916585fda34255fd62a134
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.24e-04	197	109	5	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 SBF2 COL1A2	1.24e-04	197	109	5	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DRD1 NFE4 ITGA8 ADCY5 CARNS1	1.24e-04	197	109	5	d1cb30ec4f3024541e9876c70bf63fe4d5c55bf1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.27e-04	198	109	5	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 MOXD1 COL1A2	1.27e-04	198	109	5	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.27e-04	198	109	5	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PDE2A NLRP1 KLHL5 TIE1	1.27e-04	198	109	5	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG5 ITGA8 LRRK1 TMEM156 CFAP54	1.30e-04	199	109	5	1bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCell	distal-1-Hematologic-EREG+_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE2A SLC40A1 CD163L1 DNAAF1 HEATR3	1.30e-04	199	109	5	15249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ITGA8 SLC40A1 MOXD1 COL1A2	1.30e-04	199	109	5	6bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell	COVID-19-kidney-Glomerular_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FLT1 PDE2A ITGA8 NLRP1 TIE1	1.30e-04	199	109	5	fffd2f9042b55531dac4e5b463b5cee80402e7bb
Disease	Vasodilators used in cardiac diseases use measurement	FLT1 MIA3 LPA	2.22e-04	34	102	3	EFO_0009926
Disease	aspirin use measurement	FLT1 MIA3 LPA	3.35e-04	39	102	3	EFO_0007013
Disease	Spastic Paraplegia	LYST HACE1	4.19e-04	9	102	2	C0037772
Disease	revision of total hip arthroplasty	RIPK4 OSBPL10	1.05e-03	14	102	2	EFO_0020973
Disease	triglycerides to total lipids in large HDL percentage	MADD LPA NLRC5	1.19e-03	60	102	3	EFO_0022330
Disease	platelet storage pool deficiency (implicated_via_orthology)	AP3B1 LYST	1.21e-03	15	102	2	DOID:2223 (implicated_via_orthology)
Disease	Narcolepsy-Cataplexy Syndrome	P2RY11 MOG	1.38e-03	16	102	2	C0751362
Disease	Narcolepsy	P2RY11 MOG	1.56e-03	17	102	2	C0027404
Disease	total lipids in very large HDL measurement	MADD LPA NLRC5	1.57e-03	66	102	3	EFO_0022312
Disease	phospholipids in very large HDL measurement	MADD LPA NLRC5	1.57e-03	66	102	3	EFO_0022298
Disease	cholesterol in very large HDL measurement	MADD LPA NLRC5	1.78e-03	69	102	3	EFO_0022229
Disease	cholesteryl ester measurement	MADD EYS LPA SBF2 NLRC5	2.02e-03	257	102	5	EFO_0010351
Disease	fibrinogen measurement, coronary artery disease	FLT1 MIA3 NOP58 LPA	2.04e-03	154	102	4	EFO_0001645, EFO_0004623
Disease	Parkinson's disease (implicated_via_orthology)	DRD1 LRRK1 SLC40A1 ADCY5	2.19e-03	157	102	4	DOID:14330 (implicated_via_orthology)
Disease	free cholesterol in large HDL measurement	MADD LPA NLRC5	2.62e-03	79	102	3	EFO_0022157
Disease	body fat percentage, coronary artery disease	MIA3 LPA	3.11e-03	24	102	2	EFO_0001645, EFO_0007800
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	ADCY5 MADD	3.37e-03	25	102	2	EFO_0004465, EFO_0004466, EFO_0004469

Protein segments in the cluster

Peptide	Gene	Start	Entry
TDCCILSALLFQGLL	CFAP54	2016	Q96N23
QSALCGLVLSLLICV	DISP3	1181	Q9P2K9
QLDLSACRLTTQCEL	CCDC88B	1216	A6NC98
ILNQICLLPILESSC	ASCC2	326	Q9H1I8
DCLVLTALLCQELGL	CARNS1	476	A5YM72
CSTASILNLCVISVD	DRD1	106	P21728
LSLLACSVFLQISCI	ADCY5	916	O95622
LFSAVVTCILLLNSC	CD163L1	21	Q9NR16
VTCILLLNSCFLISS	CD163L1	26	Q9NR16
LEVTDTCLNGLVCLL	AP3B1	436	O00203
TLCLQLLILCCQTQG	FGF17	11	O60258
QTQVILNCSALPCLL	KPNA5	331	O15131
LQLLLCACTSVTDLT	NFE4	56	Q86UQ8
CLDTCGDLLVTLQSL	NOMO3	511	P69849
LAAQACSLETTVCLL	ANKAR	576	Q7Z5J8
ICDISLILQLSCSDT	OR6C70	176	A6NIJ9
LVLLLSQLCVCVAQE	FHIP1B	176	Q8N612
ICNILHLCTQVIEIS	NOP58	251	Q9Y2X3
ALEILTNATQCTLLC	OSGEPL1	336	Q9H4B0
CALNVLSTIVCALAT	FAM189A1	181	O60320
SQCLTESLCALVASQ	HSP90B2P	276	Q58FF3
CLDTCGDLLVTLQSL	NOMO2	511	Q5JPE7
CNLLGSVIFITCISL	P2RY11	111	Q96G91
LCTRCIQINTDSSLL	FLII	1066	Q13045
LELLGVDACLQVLTC	MADD	301	Q8WXG6
LSSNLDVNLCLDKTC	EYS	1651	Q5T1H1
NVLLLEENASDLCCL	MTMR12	386	Q9C0I1
SLESLIANLCACLVP	SBF2	151	Q86WG5
IENCNLTQLTCESLA	NLRP8	846	Q86W28
LTQLTCESLASCLRQ	NLRP8	851	Q86W28
ISCQITELDLSANCL	LRRK1	276	Q38SD2
TLISLVLVFCCLTEN	NLRP11	776	P59045
CLQADICLHLNQTLL	KCNH7	726	Q9NS40
DCVVQLSTLSCLQPL	MMS19	926	Q96T76
SISVLLVACNILCLL	LMBR1	306	Q8WVP7
SLQAACCAALTELVL	NEK10	386	Q6ZWH5
LCGIEAQACILNTTL	ISOC2	106	Q96AB3
RCCLLLVSEDNLQLS	PDE2A	261	O00408
LQRLQLVSCGLTSDC	NLRP1	896	Q9C000
IAANCGSVECLVLLL	HACE1	71	Q8IYU2
CLDTCGDLLVTLQSL	NOMO1	511	Q15155
ICFLTLRLSASQNCL	MANSC1	16	Q9H8J5
LLLLVCHVLTQATAC	GPR152	206	Q8TDT2
DVILCSLSTQQLECV	ELP1	91	O95163
LNCEAVLQLLTCHLR	TEPSIN	276	Q96N21
ICCNSCELTNITIAI	FSHB	16	P01225
LAVALLSNALVLLCC	GPR78	16	Q96P69
ECLLSTACLLQLSQV	KLHL5	291	Q96PQ7
ILNCTNIECLQISCA	ITGA8	921	P53708
SCLCSFLLLLLLQVS	MOG	11	Q16653
LAGALQLTQSRVLCC	LRRC8B	41	Q6P9F7
LQLTELTLTQCCLGQ	NLRC5	1351	Q86WI3
LAVCCGSASIVNLLL	POTEB3	311	A0JP26
CALNALTTTVCLVAA	FAM189A2	91	Q15884
SSLLQLLQNTCLDCE	GSAP	411	A4D1B5
LLLAVTLCLATCQSL	COL1A2	11	P08123
TLCLATCQSLQEETV	COL1A2	16	P08123
TIQCRALFCLQSLVS	HEATR3	461	Q7Z4Q2
SSLCAIICFLNLVIE	CLLU1	21	Q5K131
ELASCLQDLQAVCSI	CEP85	676	Q6P2H3
CNLTQCLVTESSVLA	LPA	1126	P08519
EGVLQILICCLQSAA	LYST	406	Q99698
QCLRLLQQASLSSTC	LYST	556	Q99698
LQECLRLCVLDLSHN	DNAAF1	216	Q8NEP3
CLTINCDSIEQPLLL	ENO4	361	A6NNW6
LNDCSCLASQAILLG	PHKB	731	Q93100
IENCICANLSVSRLS	OR56A1	181	Q8NGH5
AASQLTCLGCLELIA	OGT	956	O15294
LAVCCGSASIVNLLL	POTEC	311	B2RU33
VLSLLGNTALILVCC	OR2G6	36	Q5TZ20
ICDLFQLLTLACTDT	OR4C6	176	Q8NH72
EAACDILSQLVNCSI	FBXL21P	131	Q9UKT6
LAVCCGSASIVNLLL	POTED	311	Q86YR6
LICNLIISGCDSTLT	RNF139	276	Q8WU17
QAILLAVCLIISACA	TMEM71	236	Q6P5X7
TNCITQLNLLECESE	MIA3	1406	Q5JRA6
QIIGNCVCLLVLSSA	LMBR1L	391	Q6UX01
QVTLCLLSTNCVLDP	PTAFR	276	P25105
CLNLSDLLAVVQLSL	NBEAL2	1236	Q6ZNJ1
NLLCHTIRLNNLCLE	PRAMEF20	396	Q5VT98
QSIIILESHIICCTL	SETX	2141	Q7Z333
SGLAQLSCLILCVIS	SLC40A1	376	Q9NP59
LIDLCSDVNVCSLLA	RIPK4	671	P57078
LSCLGECLNLLQQSV	OSBPL10	286	Q9BXB5
ALFLCLCLLTLQNAT	ADGRG5	6	Q8IZF4
TSNQILTSECLSCLV	CIP2A	46	Q8TCG1
RTLELSCLEVCLQSN	TMEM156	31	Q8N614
CSAILTLCLESQVLS	SLC35G4	141	P0C7Q5
DLAITSLLLLNQCLE	PDCD11	806	Q14690
SLRENICLLQTFSLC	TSPAN33	86	Q86UF1
LSTNLQEEATCAICL	TRIM11	6	Q96F44
VLLSICSLLTDCNPA	UBE2E2	156	Q96LR5
NLLVCLLLLSCTLST	MOXD1	596	Q6UVY6
ALLLSICSACGQLFI	SLC35B2	341	Q8TB61
ATCLTILAALLTLVC	TIE1	771	P35590
VSACVLLTQCLRDLA	TLNRD1	296	Q9H1K6
NAISQCLCSILPLVE	USP50	56	Q70EL3
LLCEINTNARLTCLG	PAK1IP1	286	Q9NWT1
LCLENLLLVHCTLQA	PRAG1	1146	Q86YV5
VDKSLLCLLCSNSQE	TRIM51G	106	A0A3B3IT33
LNCCDSLIAVQLIIS	XKR3	371	Q5GH77
CVSAQTLLLQLLQSC	ZZEF1	786	O43149
ICTTCLLSVLQAITI	VN1R17P	101	Q8TDU5
TLCLVCIVANALLLV	TM4SF5	16	O14894
ELSLSGLCQCLVELS	TARBP2	316	Q15633
ATCALLLALICSVQL	SCGB2B2	6	Q4G0G5
LLALICSVQLGDACL	SCGB2B2	11	Q4G0G5
SKVLLSICSLLTDCN	UBE2E1	146	P51965
NLELITLTCTCVAAT	FLT1	756	P17948
ISATCLLLCLNLFVA	TMEM202	161	A6NGA9
ALQCALALEISSVTC	SPATA6	6	Q9NWH7
CVLLCVSLSLAVSGQ	ZP4	6	Q12836
SALLACLQDLDLNLC	ZNF683	71	Q8IZ20
NDLSVLRQLLLDCTC	TRPV5	56	Q9NQA5
ICNLLTETATLCLDV	ULK4	1081	Q96C45
LTKLCTLNLSCNLIT	LRRCC1	86	Q9C099
LTNACCLDLASVILN	NLRP14	941	Q86W24