Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	KRAB	ZNF26 ZNF527 ZNF732 ZNF268 ZNF233 ZNF749 ZNF850 ZNF583	7.04e-06	358	53	8	PS50805
Domain	KRAB	ZNF26 ZNF527 ZNF732 ZNF268 ZNF233 ZNF749 ZNF850 ZNF583	7.04e-06	358	53	8	PF01352
Domain	KRAB	ZNF26 ZNF527 ZNF732 ZNF268 ZNF233 ZNF749 ZNF850 ZNF583	8.78e-06	369	53	8	SM00349
Domain	KRAB	ZNF26 ZNF527 ZNF732 ZNF268 ZNF233 ZNF749 ZNF850 ZNF583	8.95e-06	370	53	8	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	9.04e-06	775	53	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	9.27e-06	777	53	11	PS00028
Domain	Znf_C2H2-like	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	1.16e-05	796	53	11	IPR015880
Domain	Znf_C2H2	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	1.29e-05	805	53	11	IPR007087
Domain	ZnF_C2H2	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	1.34e-05	808	53	11	SM00355
Domain	-	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZNF583	1.79e-05	679	53	10	3.30.160.60
Domain	zf-C2H2	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZNF583	2.13e-05	693	53	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZNF583	2.16e-05	694	53	10	IPR013087
Domain	ARM-type_fold	DOCK11 PIK3C2G ELMO2 EIF4G1 ZYG11B ARMC9 UNC45A	4.59e-05	339	53	7	IPR016024
Domain	-	CDC42BPG DOCK11 ELMO2 PLCB3 TNS3 FARP2	8.10e-04	391	53	6	2.30.29.30
Domain	PH_dom-like	CDC42BPG DOCK11 ELMO2 PLCB3 TNS3 FARP2	1.26e-03	426	53	6	IPR011993
Domain	zf-C2H2_6	ZNF26 ZNF527 ZNF732 ZNF749 ZNF850	1.93e-03	314	53	5	PF13912
Domain	-	ELMO2 ZYG11B ARMC9 UNC45A	3.61e-03	222	53	4	1.25.10.10
Domain	ARM-like	ELMO2 ZYG11B ARMC9 UNC45A	7.18e-03	270	53	4	IPR011989
Domain	PH	CDC42BPG DOCK11 ELMO2 FARP2	7.94e-03	278	53	4	SM00233
Domain	PH_DOMAIN	CDC42BPG DOCK11 ELMO2 FARP2	8.04e-03	279	53	4	PS50003
Domain	PH_domain	CDC42BPG DOCK11 ELMO2 FARP2	8.14e-03	280	53	4	IPR001849
Domain	C2_dom	PIK3C2G PLCB3 TNS3	1.13e-02	164	53	3	IPR000008
Pubmed	Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity.	EIF4E EIF4G1	2.55e-06	2	56	2	23901100
Pubmed	Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism.	EIF4E EIF4G1	2.55e-06	2	56	2	15897904
Pubmed	Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.	EIF4E EIF4G1	2.55e-06	2	56	2	25049413
Pubmed	p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation.	EIF4E EIF4G1	2.55e-06	2	56	2	12149653
Pubmed	Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs.	EIF4E EIF4G1	2.55e-06	2	56	2	23079111
Pubmed	LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage.	ERCC6 LEO1	2.55e-06	2	56	2	34096589
Pubmed	Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection.	EIF4E EIF4G1	2.55e-06	2	56	2	20053821
Pubmed	Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI.	EIF4E EIF4G1	2.55e-06	2	56	2	27501049
Pubmed	The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation.	EIF4E EIF4G1	2.55e-06	2	56	2	20360945
Pubmed	The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.	EIF4E EIF4G1	2.55e-06	2	56	2	27162083
Pubmed	Amino acid-induced stimulation of translation initiation in rat skeletal muscle.	EIF4E EIF4G1	2.55e-06	2	56	2	10600798
Pubmed	Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1.	EIF4E EIF4G1	2.55e-06	2	56	2	12239292
Pubmed	Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex.	EIF4E EIF4G1	2.55e-06	2	56	2	18614538
Pubmed	The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.	EIF4E EIF4G1	2.55e-06	2	56	2	27773676
Pubmed	Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.	EIF4E EIF4G1	2.55e-06	2	56	2	35163752
Pubmed	Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells.	EIF4E EIF4G1	2.55e-06	2	56	2	32421011
Pubmed	eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling.	EIF4E EIF4G1	2.55e-06	2	56	2	25717031
Pubmed	Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.	EIF4E EIF4G1	2.55e-06	2	56	2	19114555
Pubmed	Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E).	EIF4E EIF4G1	7.63e-06	3	56	2	31201269
Pubmed	Exaggerated translation causes synaptic and behavioural aberrations associated with autism.	EIF4E EIF4G1	7.63e-06	3	56	2	23263185
Pubmed	Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast.	EIF4E EIF4G1	7.63e-06	3	56	2	37449412
Pubmed	Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.	EIF4E EIF4G1	7.63e-06	3	56	2	20212144
Pubmed	Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.	EIF4E EIF4G1	7.63e-06	3	56	2	18250159
Pubmed	Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.	EIF4E EIF4G1	7.63e-06	3	56	2	26951381
Pubmed	Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: comparison with eIF4E-binding protein.	EIF4E EIF4G1	7.63e-06	3	56	2	21964297
Pubmed	Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.	EIF4E EIF4G1	7.63e-06	3	56	2	25923732
Pubmed	Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.	EIF4E EIF4G1	7.63e-06	3	56	2	20971826
Pubmed	Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.	EIF4E EIF4G1	7.63e-06	3	56	2	24990923
Pubmed	Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.	EIF4E EIF4G1	7.63e-06	3	56	2	16720573
Pubmed	The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.	EIF4E EIF4G1	7.63e-06	3	56	2	19850929
Pubmed	Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.	EIF4E EIF4G1	7.63e-06	3	56	2	12071973
Pubmed	Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.	EIF4E EIF4G1	7.63e-06	3	56	2	10880459
Pubmed	In vitro studies reveal that different modes of initiation on HIV-1 mRNA have different levels of requirement for eukaryotic initiation factor 4F.	EIF4E EIF4G1	7.63e-06	3	56	2	22759308
Pubmed	Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.	EIF4E EIF4G1	7.63e-06	3	56	2	15220445
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ERBB4 DOCK11 ELMO2 PARP8 EIF4G1 ZNF629 TANC1 UNC45A TNS3	8.95e-06	861	56	9	36931259
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG LEO1 ELMO2 ZNF629 UGGT2 PLCB3 TANC1 FARP2	9.19e-06	650	56	8	38777146
Pubmed	Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.	EIF4E EIF4G1	1.52e-05	4	56	2	15897901
Pubmed	The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.	EIF4E EIF4G1	1.52e-05	4	56	2	8449919
Pubmed	Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.	EIF4E EIF4G1	1.52e-05	4	56	2	8521827
Pubmed	Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.	EIF4E EIF4G1	1.52e-05	4	56	2	11408474
Pubmed	Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2.	EIF4E EIF4G1	1.52e-05	4	56	2	16281055
Pubmed	Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.	EIF4E EIF4G1	1.52e-05	4	56	2	17601486
Pubmed	Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.	EIF4E EIF4G1	1.52e-05	4	56	2	15961545
Pubmed	The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.	EIF4E EIF4G1	1.52e-05	4	56	2	7651417
Pubmed	The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G.	EIF4E EIF4G1	1.52e-05	4	56	2	22509910
Pubmed	c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.	EIF4E EIF4G1	1.52e-05	4	56	2	18593934
Pubmed	DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.	EIF4E EIF4G1	1.52e-05	4	56	2	22872150
Pubmed	Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.	EIF4E EIF4G1	1.52e-05	4	56	2	9372926
Pubmed	SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G.	EIF4E EIF4G1	1.52e-05	4	56	2	24971752
Pubmed	Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.	EIF4E EIF4G1	1.52e-05	4	56	2	7935836
Pubmed	Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.	EIF4E EIF4G1	1.52e-05	4	56	2	21191102
Pubmed	Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase.	EIF4E EIF4G1	2.54e-05	5	56	2	10753870
Pubmed	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	EIF4E EIF4G1	2.54e-05	5	56	2	19239892
Pubmed	Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.	EIF4E EIF4G1	2.54e-05	5	56	2	16648488
Pubmed	Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation.	EIF4E EIF4G1	2.54e-05	5	56	2	29987188
Pubmed	The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.	EIF4E EIF4G1	2.54e-05	5	56	2	12897141
Pubmed	The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.	EIF4E EIF4G1	2.54e-05	5	56	2	11154262
Pubmed	A novel functional human eukaryotic translation initiation factor 4G.	EIF4E EIF4G1	2.54e-05	5	56	2	9418880
Pubmed	Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.	EIF4E EIF4G1	2.54e-05	5	56	2	9878069
Pubmed	Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.	EIF4E EIF4G1	2.54e-05	5	56	2	27864334
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	CDCA3 APLP2 PLCB3 TANC1 SLC39A10 TNS3 FARP2	3.50e-05	569	56	7	30639242
Pubmed	Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.	EIF4E EIF4G1	3.80e-05	6	56	2	18955708
Pubmed	Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f).	EIF4E EIF4G1	3.80e-05	6	56	2	30573685
Pubmed	Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E.	EIF4E EIF4G1	3.80e-05	6	56	2	23814182
Pubmed	eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.	EIF4E EIF4G1	3.80e-05	6	56	2	18426977
Pubmed	Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.	EIF4E EIF4G1	3.80e-05	6	56	2	17556672
Pubmed	Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.	EIF4E EIF4G1	3.80e-05	6	56	2	10022874
Pubmed	Differential Requirements for eIF4E Dose in Normal Development and Cancer.	EIF4E EIF4G1	3.80e-05	6	56	2	26095252
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CDCA3 LEO1 ZFYVE16 APLP2 ZYG11B TANC1 NUDCD3 SLC39A10 TNS3	4.23e-05	1049	56	9	27880917
Pubmed	eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.	EIF4E EIF4G1	5.32e-05	7	56	2	23665581
Pubmed	Characterization of mammalian eIF4E-family members.	EIF4E EIF4G1	5.32e-05	7	56	2	15153109
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	DAP3 ELMO2 LPIN2 TANC1	5.54e-05	128	56	4	25332235
Pubmed	mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.	EIF4E EIF4G1	7.09e-05	8	56	2	16541103
Pubmed	Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.	EIF4E EIF4G1	9.10e-05	9	56	2	22586265
Pubmed	eIF4G is required for the pioneer round of translation in mammalian cells.	EIF4E EIF4G1	9.10e-05	9	56	2	15361857
Pubmed	Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.	EIF4E EIF4G1	9.10e-05	9	56	2	19262567
Pubmed	NEDDylation promotes stress granule assembly.	EIF4E EIF4G1	1.14e-04	10	56	2	27381497
Pubmed	Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.	EIF4E EIF4G1	1.14e-04	10	56	2	12388085
Pubmed	The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.	EIF4E EIF4G1	1.14e-04	10	56	2	23788676
Pubmed	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	G3BP2 EIF4G1	1.14e-04	10	56	2	31114027
Pubmed	H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.	EIF4E EIF4G1	1.66e-04	12	56	2	34704401
Pubmed	An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.	EIF4E EIF4G1	1.66e-04	12	56	2	25456498
Pubmed	G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.	G3BP2 EIF4G1	1.66e-04	12	56	2	27022092
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	G3BP2 EIF4E EIF4G1 USP29 UGGT2 ZYG11B UNC45A NUDCD3	1.97e-04	1005	56	8	19615732
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	HDHD5 G3BP2 EIF4G1 GMDS UNC45A	1.97e-04	332	56	5	29053956
Pubmed	TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.	PARD6B TEAD4	2.29e-04	14	56	2	38206180
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	CDCA3 ZFYVE16 EIF4G1 PLCB3 TANC1 UNC45A	2.92e-04	565	56	6	25468996
Pubmed	The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.	EIF4E EIF4G1	3.01e-04	16	56	2	37307456
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ERBB4 ADAMTS20	3.41e-04	17	56	2	22183742
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	DAP3 LEO1 HDHD5 G3BP2 EIF4E EIF4G1 GMDS PLCB3 UNC45A	4.02e-04	1415	56	9	28515276
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	LEO1 EIF4E EIF4G1 GMDS PLCB3 ARMC9 UNC45A NUDCD3 TNS3	4.92e-04	1455	56	9	22863883
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PARD6B ERBB4 ELMO2 SLC39A10 FARP2	5.84e-04	421	56	5	36976175
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PARD6B ERCC6 EIF4E EIF4G1 APLP2 TANC1 UNC45A ZHX1 FARP2	6.04e-04	1497	56	9	31527615
Pubmed	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	TTL FARP2	6.30e-04	23	56	2	20468071
Pubmed	Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.	TEAD4 CDH3	6.30e-04	23	56	2	18083014
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZNF26 ZNF268 TTL ADAMTS20 PLCB3 NUDCD3 CDH3 ZHX1	6.95e-04	1215	56	8	15146197
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF527 ELMO2 ARMC9	6.97e-04	107	56	3	11347906
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DAP3 G3BP2 EIF4E APLP2	7.25e-04	251	56	4	28077445
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CDCA3 ZFYVE16 TANC1 UNC45A	8.62e-04	263	56	4	34702444
Pubmed	Protein translation rate determines neocortical neuron fate.	EIF4E EIF4G1	8.71e-04	27	56	2	38849354
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF527 GPATCH1 USP29 ZNF233 ZNF749 ZNF850 ZNF583 DKKL1 KPTN	1.32e-05	1192	56	9	chr19q13
Cytoband	19q13.43	USP29 ZNF749 ZNF583	1.69e-04	87	56	3	19q13.43
Cytoband	12q24.33	ZNF26 ZNF268	1.59e-03	48	56	2	12q24.33
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF26 ZNF527 ZNF732 ZNF268 ZNF335 ZNF629 ZNF233 ZNF749 ZNF850 ZHX1 ZNF583	8.30e-07	718	44	11	28
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_UP	CDCA3 SLC9A9 ERBB4 LEO1 ZNF335 LPIN2	4.33e-06	200	56	6	M6713
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 ADAMTS20 TANC1	3.40e-06	183	56	5	d2074b13b4831ec18c81273d9a1ff673c3f6a16d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 ADAMTS20 TANC1	3.68e-06	186	56	5	948815663c212c4311329d503b5991cbbbff9808
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 ADAMTS20 TANC1	4.09e-06	190	56	5	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 ADAMTS20 TANC1	4.52e-06	194	56	5	e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PARD6B JADE3 PIK3C2G CDH3	4.01e-05	152	56	4	6f9c343669883618cd9c1c8921a90c34d153f303
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KY PIK3C2G ZNF629 ZNF583	4.33e-05	155	56	4	8b524c65fa5c901f70c7caae4ec7fd2859eaf227
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KY PIK3C2G ZNF629 ZNF583	4.33e-05	155	56	4	7fe8b8c0c8a9e3190cfd52d3934509e6780e1717
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDHD5 UGGT2 TEAD4 ZHX1	5.39e-05	164	56	4	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDHD5 UGGT2 TEAD4 ZHX1	5.39e-05	164	56	4	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEK6 ADAMTS20 APLP2 SPAG17	5.52e-05	165	56	4	b1bbf5acdfc52bd8c7c7eb356d73b812eb6b908c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEK6 ADAMTS20 APLP2 SPAG17	5.52e-05	165	56	4	28f8297ec7b781149cc7ac2f5e441771083b8ee3
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	GPD1L JADE3 UGGT2 TNS3	6.63e-05	173	56	4	67f0f0bf88eab69987b71d96b864ed2b14975adb
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	7.25e-05	177	56	4	91706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	7.74e-05	180	56	4	8f774dcacc1626e4e6492f1eb927b0ed56fbe686
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	7.90e-05	181	56	4	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 ADAMTS20	8.42e-05	184	56	4	c4c1a3d279ca733b865ce46570d7642dc137f9a4
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JADE3 DOCK11 PIK3C2G USP29	8.78e-05	186	56	4	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	NEK6 JADE3 TNS3 FARP2	8.96e-05	187	56	4	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	NEK6 JADE3 TNS3 FARP2	8.96e-05	187	56	4	af1327559f7e01bec070881cae52834917c3da65
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	9.15e-05	188	56	4	72cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	9.34e-05	189	56	4	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	9.53e-05	190	56	4	d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	NEK6 JADE3 TNS3 FARP2	9.53e-05	190	56	4	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	9.53e-05	190	56	4	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	9.53e-05	190	56	4	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	SLC9A9 DOCK11 PARP8 TNS3	9.73e-05	191	56	4	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	SLC9A9 DOCK11 PARP8 TNS3	9.92e-05	192	56	4	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	PARD6B ERBB4 TANC1 SPAG17	9.92e-05	192	56	4	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	SLC9A9 DOCK11 PARP8 TNS3	9.92e-05	192	56	4	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	1.01e-04	193	56	4	53bcd50892c379b2a571751f6eb1062436339fe7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	1.01e-04	193	56	4	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	SLC9A9 DOCK11 PARP8 TNS3	1.01e-04	193	56	4	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A9 ERBB4 DOCK11 TANC1	1.01e-04	193	56	4	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	COVID-19-Heart-Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	SLC9A9 DOCK11 PARP8 TNS3	1.03e-04	194	56	4	f09675cd472200363c458952f00d2e41990800ee
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B ERBB4 PIK3C2G CDH3	1.03e-04	194	56	4	c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCell	LA-08._Macrophage\|World / Chamber and Cluster_Paper	SLC9A9 DOCK11 PARP8 TNS3	1.03e-04	194	56	4	c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B ERBB4 PIK3C2G CDH3	1.07e-04	196	56	4	7b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B ERBB4 PIK3C2G CDH3	1.07e-04	196	56	4	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK11 EIF4E APLP2 TNS3	1.12e-04	198	56	4	93cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCell	PCW_13-14-Epithelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B ERBB4 PIK3C2G CDH3	1.12e-04	198	56	4	48eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 DOCK11 ADAMTS20 TANC1	1.16e-04	200	56	4	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 ERBB4 DOCK11 TANC1	1.16e-04	200	56	4	1276bfa911fddada4235e12e3081baa53164574b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ERBB4 GMDS APLP2 CDH3	1.16e-04	200	56	4	ae91dc047dc80560ba298d8d21a772154fa2775d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	PARD6B ZFYVE16 APLP2 SPAG17	1.16e-04	200	56	4	5fb90118d3abc28d72bc483e68317255090a04c7
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 ERBB4 DOCK11 TANC1	1.16e-04	200	56	4	c65e6336725856c4b5f6aeba1cf86a23ec815d34
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 ERBB4 DOCK11 TANC1	1.16e-04	200	56	4	117a25b3b9cdbc2e198381350a8362bee25e82e7
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 ERBB4 DOCK11 TANC1	1.16e-04	200	56	4	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 ERBB4 DOCK11 TANC1	1.16e-04	200	56	4	d459e51507bf26865e6e7e04411379ec82a3edf8
Drug	Clorsulon [60200-06-8]; Down 200; 10.6uM; HL60; HG-U133A	GPD1L ERCC6 ELMO2 GPATCH1 UGGT2 PLCB3	7.69e-06	196	55	6	1735_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A	ELMO2 ZNF629 GMDS PLCB3 UNC45A TEAD4	8.15e-06	198	55	6	6332_DN
Disease	colorectal cancer	PARD6B ERBB4 GPATCH1 USP29 TANC1 UNC45A CDH3 TNS3	8.63e-06	604	51	8	MONDO_0005575
Disease	Vitiligo	NEK6 PLCB3 FARP2	7.19e-04	101	51	3	EFO_0004208
Disease	autistic disorder (is_implicated_in)	SLC9A9 EIF4E	2.41e-03	42	51	2	DOID:12849 (is_implicated_in)
Disease	Hepatic fibrosis	ERBB4 CDH3	3.27e-03	49	51	2	HP_0001395
Disease	uric acid measurement	CDC42BPG ERBB4 GMDS TANC1 FARP2	3.99e-03	610	51	5	EFO_0004761
Disease	polyp of colon	CDH3 TNS3	4.25e-03	56	51	2	MONDO_0021400
Disease	urate measurement	CDC42BPG ERBB4 GMDS UGGT2 PLCB3 FARP2	4.31e-03	895	51	6	EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
EYVHEHKDNIGSQLL	ERBB4	806	Q15303
HYVILDEGHKIRNPN	ERCC6	641	Q03468
DGNEYEDGHNKPHLI	ADAMTS20	171	P59510
EDGHNKPHLIYRQDL	ADAMTS20	176	P59510
EQGQDHDKENQHFPL	CDCA3	251	Q99618
PNESHEKQYEHQEFL	PIK3C2G	11	O75747
LEKELENENHNYHIG	PIK3C2G	156	O75747
LHQLGYVHRDVKPDN	CDC42BPG	186	Q6DT37
EEFYGLLQHVHKIPN	PARD6B	41	Q9BYG5
HGDLLPINNDDNYHK	PARD6B	66	Q9BYG5
TPEERHLNKMQNHGY	APLP2	736	Q06481
QVNYDGELHKHPQLE	PARP8	141	Q8N3A8
VFDVYKAPLQGDHNH	LEO1	456	Q8WVC0
EHLYKNPQAHIEGNM	GMDS	66	O60547
DYHQKLQGKPQSHEL	NUDCD3	311	Q8IVD9
INNDHENVKYLPGHK	GPD1L	56	Q8N335
EGNDFHENLVEKQHP	KY	61	Q8NBH2
LGHENHEIQPYVNGA	ARMC9	511	Q7Z3E5
QEVANPEHYIKHPLQ	EIF4E	26	P06730
LPGNYHKEENQEHQL	DKKL1	81	Q9UK85
DNVHGLAYKGLDPHQ	GPATCH1	231	Q9BRR8
NDPAIHLYKENEGLH	KPTN	166	Q9Y664
HQRPDIGYVHQVAKQ	NEK6	291	Q9HC98
DHQDYAEALINPIKH	PLCB3	851	Q01970
HQNSYQPGRKHGEQE	CEFIP	206	Q711Q0
VSHHNQNPEFYDEIK	DOCK11	701	Q5JSL3
HKVLHYGDLDDNPQG	ELMO2	576	Q96JJ3
PQEAVYGQNDIHHKV	G3BP2	51	Q9UN86
GHDQSQHLTQEYLPK	DUXB	86	A0A1W2PPF3
IHNAENIQPGEQKYE	EIF4G1	581	Q04637
REHLKVNEYLPGQQH	FARP2	181	O94887
HGKYILNVEHSENQP	DYNAP	31	Q8N1N2
DQGEQYEHNRVHKPD	SLC39A10	256	Q9ULF5
QKYEAHVPENAVGHE	CDH3	331	P22223
SQNRQKLGEAEYPHH	JADE3	366	Q92613
DQHEGQHYNISPQDL	DAP3	61	P51398
YKREISQHNINPHQG	SLC9A9	106	Q8IVB4
HQYLQKATHDGAPEL	HDHD5	326	Q9BXW7
PDNKDIHSDLHAYVQ	TANC1	651	Q9C0D5
TPEKIQGSEHLYNDH	TNS3	301	Q68CZ2
HLEKNHQQIYGEHVP	SPAG17	1626	Q6Q759
EEGGLQHLYNIKDHE	ZYG11B	691	Q9C0D3
LFEHQKTHNGERPYE	ZNF749	211	O43361
LLVHQQTHAEEKPYG	ZNF268	291	Q14587
ALSEHNLKYHPGEEN	ZHX1	116	Q9UKY1
HLQEVPQHPELQKYE	USP29	681	Q9HBJ7
QQDPDTYNKHLFVHI	TEAD4	236	Q15561
NLNAHQRVHTGEKPY	ZNF26	216	P17031
NLQAHQRIHTGEKPY	ZNF233	466	A6NK53
LQDHQQVHTGENPYK	ZNF233	551	A6NK53
HQGKSEDIYQIVGHE	UGGT2	1146	Q9NYU1
DLTQHQGIHAGEKPY	ZNF732	181	B4DXR9
QHQRIHIGENPYKNA	ZNF629	586	Q9UEG4
PEHIQQLQHQGIEYD	ZNF335	1321	Q9H4Z2
QGQVHVIQKYLEHPL	TTL	176	Q8NG68
ELAKYAKQHVPEQHP	UNC45A	611	Q9H3U1
AYLDQHQRVHTGEKP	ZNF583	421	Q96ND8
LNQHQQIHTGEKPYH	ZNF850	296	A8MQ14
LIQHQQNHTDEKPYD	ZNF850	716	A8MQ14
DFLPQHEHKDNIQDA	ZFYVE16	396	Q7Z3T8
LNQHQRIHTGEKPYE	ZNF527	401	Q8NB42
LNQHQRIHTGEKPYE	ZNF527	541	Q8NB42
VHKRSQHQGPDDIYL	LPIN2	391	Q92539