Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	3.72e-06	2	39	2	GO:0003989
GeneOntologyMolecularFunction	activin receptor activity, type I	TGFBR1 ACVR1C	3.70e-05	5	39	2	GO:0016361
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD9 CHD8 CHD6	5.11e-05	37	39	3	GO:0140658
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	5.55e-05	6	39	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	5.55e-05	6	39	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	7.76e-05	7	39	2	GO:0016885
GeneOntologyMolecularFunction	activin receptor activity	TGFBR1 ACVR1C	1.33e-04	9	39	2	GO:0017002
GeneOntologyMolecularFunction	activin binding	TGFBR1 ACVR1C	2.42e-04	12	39	2	GO:0048185
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	TGFBR1 ACVR1C	6.91e-04	20	39	2	GO:0004675
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC11 FCN2	1.08e-03	25	39	2	GO:0033691
GeneOntologyMolecularFunction	carboxylic acid binding	SIGLEC11 ACACA ACACB FCN2	1.18e-03	239	39	4	GO:0031406
GeneOntologyMolecularFunction	organic acid binding	SIGLEC11 ACACA ACACB FCN2	1.48e-03	254	39	4	GO:0043177
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD9 CHD8 CHD6	1.94e-03	127	39	3	GO:0008094
GeneOntologyMolecularFunction	helicase activity	CHD9 CHD8 CHD6	3.61e-03	158	39	3	GO:0004386
GeneOntologyMolecularFunction	proteoglycan binding	LRP1 FCN2	4.46e-03	51	39	2	GO:0043394
GeneOntologyMolecularFunction	calcium channel regulator activity	PACSIN3 GRM2	4.99e-03	54	39	2	GO:0005246
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	3.48e-06	2	39	2	GO:2001295
GeneOntologyBiologicalProcess	malonyl-CoA metabolic process	ACACA ACACB	5.20e-05	6	39	2	GO:2001293
GeneOntologyBiologicalProcess	intracellular glutamate homeostasis	ACACB GRM2	5.20e-05	6	39	2	GO:0090461
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway	LRP1 USP34 HNF1A CHD8 ITGA3 LZTS2	6.14e-05	368	39	6	GO:0030111
GeneOntologyBiologicalProcess	intracellular amino acid homeostasis	ACACB GRM2	1.55e-04	10	39	2	GO:0080144
GeneOntologyBiologicalProcess	transforming growth factor beta receptor signaling pathway	LRP1 TGFBR1 ITGA3 ACVR1C SNX1	1.64e-04	276	39	5	GO:0007179
GeneOntologyCellularComponent	activin receptor complex	TGFBR1 ACVR1C	5.06e-05	6	39	2	GO:0048179
Domain	BRK	CHD9 CHD8 CHD6	1.68e-07	6	39	3	SM00592
Domain	BRK_domain	CHD9 CHD8 CHD6	1.68e-07	6	39	3	IPR006576
Domain	BRK	CHD9 CHD8 CHD6	1.68e-07	6	39	3	PF07533
Domain	AcCoA_COase_cen	ACACA ACACB	4.25e-06	2	39	2	IPR013537
Domain	ACC_central	ACACA ACACB	4.25e-06	2	39	2	PF08326
Domain	Chromo_domain	CHD9 CHD8 CHD6	1.65e-05	24	39	3	IPR023780
Domain	Chromo	CHD9 CHD8 CHD6	2.12e-05	26	39	3	PF00385
Domain	Carboxyl_trans	ACACA ACACB	2.54e-05	4	39	2	PF01039
Domain	COA_CT_N	ACACA ACACB	2.54e-05	4	39	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	2.54e-05	4	39	2	IPR011763
Domain	COA_CT_CTER	ACACA ACACB	2.54e-05	4	39	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	2.54e-05	4	39	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	2.54e-05	4	39	2	PS50980
Domain	CHROMO_2	CHD9 CHD8 CHD6	2.66e-05	28	39	3	PS50013
Domain	CHROMO_1	CHD9 CHD8 CHD6	2.66e-05	28	39	3	PS00598
Domain	SNF2_N	CHD9 CHD8 CHD6	4.00e-05	32	39	3	PF00176
Domain	SNF2_N	CHD9 CHD8 CHD6	4.00e-05	32	39	3	IPR000330
Domain	Chromodomain-like	CHD9 CHD8 CHD6	4.00e-05	32	39	3	IPR016197
Domain	Biotin_COase_C	ACACA ACACB	4.23e-05	5	39	2	IPR005482
Domain	Biotin_BS	ACACA ACACB	4.23e-05	5	39	2	IPR001882
Domain	Biotin_carb_C	ACACA ACACB	4.23e-05	5	39	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	4.23e-05	5	39	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	4.23e-05	5	39	2	IPR011764
Domain	BIOTIN	ACACA ACACB	4.23e-05	5	39	2	PS00188
Domain	CPSASE_1	ACACA ACACB	4.23e-05	5	39	2	PS00866
Domain	BC	ACACA ACACB	4.23e-05	5	39	2	PS50979
Domain	CHROMO	CHD9 CHD8 CHD6	4.40e-05	33	39	3	SM00298
Domain	Chromo/shadow_dom	CHD9 CHD8 CHD6	4.40e-05	33	39	3	IPR000953
Domain	Rudment_hybrid_motif	ACACA ACACB	6.34e-05	6	39	2	IPR011054
Domain	CPSASE_2	ACACA ACACB	6.34e-05	6	39	2	PS00867
Domain	GS	TGFBR1 ACVR1C	8.86e-05	7	39	2	SM00467
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	8.86e-05	7	39	2	IPR005479
Domain	BC-like_N	ACACA ACACB	8.86e-05	7	39	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	8.86e-05	7	39	2	PF00289
Domain	GS_dom	TGFBR1 ACVR1C	8.86e-05	7	39	2	IPR003605
Domain	TGF_beta_GS	TGFBR1 ACVR1C	8.86e-05	7	39	2	PF08515
Domain	CPSase_L_D2	ACACA ACACB	8.86e-05	7	39	2	PF02786
Domain	GS	TGFBR1 ACVR1C	8.86e-05	7	39	2	PS51256
Domain	Biotin_lipoyl	ACACA ACACB	1.52e-04	9	39	2	PF00364
Domain	Activin_recp	TGFBR1 ACVR1C	1.89e-04	10	39	2	IPR000472
Domain	Biotin_lipoyl	ACACA ACACB	1.89e-04	10	39	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.89e-04	10	39	2	PS50968
Domain	Activin_recp	TGFBR1 ACVR1C	1.89e-04	10	39	2	PF01064
Domain	TGFB_receptor	TGFBR1 ACVR1C	2.77e-04	12	39	2	IPR000333
Domain	Single_hybrid_motif	ACACA ACACB	2.77e-04	12	39	2	IPR011053
Domain	-	ACACA ACACB	3.27e-04	13	39	2	3.40.50.20
Domain	ATP-grasp	ACACA ACACB	3.81e-04	14	39	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	3.81e-04	14	39	2	IPR016185
Domain	ATP_GRASP	ACACA ACACB	3.81e-04	14	39	2	PS50975
Domain	-	ACACA ACACB	4.39e-04	15	39	2	3.30.1490.20
Domain	-	ACACA ACACB	6.36e-04	18	39	2	3.30.470.20
Domain	ATP_grasp_subdomain_1	ACACA ACACB	6.36e-04	18	39	2	IPR013815
Domain	-	ACACA ACACB	8.70e-04	21	39	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACA ACACB	8.70e-04	21	39	2	IPR029045
Domain	Helicase_C	CHD9 CHD8 CHD6	1.44e-03	107	39	3	PF00271
Domain	HELICc	CHD9 CHD8 CHD6	1.44e-03	107	39	3	SM00490
Domain	Helicase_C	CHD9 CHD8 CHD6	1.48e-03	108	39	3	IPR001650
Domain	HELICASE_CTER	CHD9 CHD8 CHD6	1.52e-03	109	39	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD9 CHD8 CHD6	1.52e-03	109	39	3	PS51192
Domain	DEXDc	CHD9 CHD8 CHD6	1.52e-03	109	39	3	SM00487
Domain	Helicase_ATP-bd	CHD9 CHD8 CHD6	1.56e-03	110	39	3	IPR014001
Domain	ATP_grasp_subdomain_2	ACACA ACACB	1.90e-03	31	39	2	IPR013816
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD6	2.42e-03	35	39	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD8 CHD6	2.85e-03	38	39	2	PS00690
Domain	SANT	RCOR3 CHD6	4.89e-03	50	39	2	SM00717
Domain	SANT/Myb	RCOR3 CHD6	5.27e-03	52	39	2	IPR001005
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	CHD9 ACACA ACACB	7.65e-05	42	28	3	M27172
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	ACACA ACACB	1.06e-04	8	28	2	M26991
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACA ACACB	1.36e-04	9	28	2	M40064
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	CHD9 ACACA ACACB	1.72e-04	55	28	3	M27001
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	2.07e-04	11	28	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	2.07e-04	11	28	2	MM14764
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	3.41e-04	14	28	2	M27098
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	3.41e-04	14	28	2	MM14788
Pathway	WP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY	ACACA ACACB	7.07e-04	20	28	2	M39751
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA ACACB	8.57e-04	22	28	2	M39440
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA ACACB	9.38e-04	23	28	2	MM15885
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	LRP1 USP34 RCOR3 CHD8 CHD6 ACACA ACACB	3.80e-07	418	39	7	34709266
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	1.23e-06	2	39	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	1.23e-06	2	39	2	27693630
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	1.23e-06	2	39	2	29433631
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	1.23e-06	2	39	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	1.23e-06	2	39	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	1.23e-06	2	39	2	29976587
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	1.23e-06	2	39	2	24944901
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	1.23e-06	2	39	2	36076520
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	1.23e-06	2	39	2	25001074
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	1.23e-06	2	39	2	15749055
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	1.23e-06	2	39	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	1.23e-06	2	39	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	1.23e-06	2	39	2	30244972
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	1.23e-06	2	39	2	20139635
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	1.23e-06	2	39	2	28081256
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	1.23e-06	2	39	2	24338821
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	1.23e-06	2	39	2	26976583
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFBR1 USP34 TMED9 MLF2 CHD8 VPS18 TSPAN14 ITGA3 SNX1	2.06e-06	1061	39	9	33845483
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	3.67e-06	3	39	2	28877461
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	3.67e-06	3	39	2	34668531
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	3.67e-06	3	39	2	20457939
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	3.67e-06	3	39	2	30018077
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	3.67e-06	3	39	2	36417534
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	3.67e-06	3	39	2	17521700
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	3.67e-06	3	39	2	28533432
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	3.67e-06	3	39	2	18455495
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	3.67e-06	3	39	2	31990961
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	3.67e-06	3	39	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	3.67e-06	3	39	2	17210641
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	3.67e-06	3	39	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	3.67e-06	3	39	2	18031993
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	3.67e-06	3	39	2	28768177
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACA ACACB	7.34e-06	4	39	2	24185692
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA ACACB	7.34e-06	4	39	2	38447582
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACA ACACB	7.34e-06	4	39	2	20952656
Pubmed	UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes.	ACVR1C ACACA	7.34e-06	4	39	2	33499275
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA ACACB	1.22e-05	5	39	2	37163372
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACA ACACB	1.22e-05	5	39	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACA ACACB	1.22e-05	5	39	2	16794074
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP34 CHD9 MLF2 CHD8 CHD6	1.55e-05	282	39	5	23667531
Pubmed	LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.	LRP1 TGFBR1	1.83e-05	6	39	2	31023188
Pubmed	CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.	LRP1 FCN2	1.83e-05	6	39	2	21054788
Pubmed	The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.	ACACA ACACB	3.42e-05	8	39	2	36001969
Pubmed	Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.	TGFBR1 ACVR1C	3.42e-05	8	39	2	16845371
Pubmed	Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.	TGFBR1 ACVR1C	4.39e-05	9	39	2	14729481
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LRP1 TGFBR1 USP34 TMED9 DOLPP1 ITGA3 SNX1 KTN1	4.68e-05	1201	39	8	35696571
Pubmed	RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.	TGFBR1 SNX1	5.48e-05	10	39	2	15239668
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	ACACA ACACB	5.48e-05	10	39	2	19720090
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TMED9 RCOR3 CHD6 ITGA3 ACACB KTN1	7.26e-05	638	39	6	31182584
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	ACACA ACACB	8.03e-05	12	39	2	21344388
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFBR1 ACVR1C	8.03e-05	12	39	2	23342175
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA ACACB	8.03e-05	12	39	2	21436046
Pubmed	Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.	TGFBR1 SNX1	1.46e-04	16	39	2	11279102
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	MLF2 VPS18 ACACA ACACB	1.55e-04	242	39	4	34011540
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RCOR3 MLF2 CHD8 CHD6 CLASRP	1.72e-04	469	39	5	27634302
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	DUOX1 ITGA3 IL3RA	1.90e-04	99	39	3	19730683
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LRP1 USP34 CHD9 RCOR3 CHD8 ITGA3 LZTS2	2.15e-04	1116	39	7	31753913
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PACSIN3 SRP19 TMED9 CHD8 CHD6 LZTS2 ZHX1 KTN1	2.16e-04	1497	39	8	31527615
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD9 CHD8 CHD6	2.52e-04	109	39	3	33554859
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	ACACA ACACB	2.54e-04	21	39	2	19217427
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA ACACB	2.79e-04	22	39	2	20965718
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACA ACACB	3.05e-04	23	39	2	14662765
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	LRP1 SNX1	3.33e-04	24	39	2	17452356
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CHD8 LZTS2 ACACA SNX1 KTN1	3.56e-04	549	39	5	38280479
Pubmed	WWP2 is an E3 ubiquitin ligase for PTEN.	ACACA ACACB	4.88e-04	29	39	2	21532586
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CHD6 LZTS2 ACACA ZHX1 CLASRP	5.66e-04	608	39	5	16713569
Pubmed	Interaction network of human early embryonic transcription factors.	TMED9 CHD8 ACACB ZHX1	6.35e-04	351	39	4	38297188
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	MLF2 CHD8 TMEM143 ACACA ACACB	6.36e-04	624	39	5	33729478
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	ACACA ACACB	6.72e-04	34	39	2	33505018
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACA ACACB	6.72e-04	34	39	2	26378152
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	RCOR3 CHD8	6.72e-04	34	39	2	30894540
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CHD8 ACACA ACACB SNX1	6.76e-04	357	39	4	37059091
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	RCOR3 CHD6 TECPR1	6.79e-04	153	39	3	10718198
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	USP34 CHD6 ACACA KTN1	7.19e-04	363	39	4	14691545
Pubmed	Human transcription factor protein interaction networks.	TMED9 RCOR3 HNF1A CHD8 CHD6 ACACB ZHX1	9.45e-04	1429	39	7	35140242
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	ACACA ACACB	1.03e-03	42	39	2	26362536
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	USP34 ACACA ACACB	1.09e-03	180	39	3	35198878
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	DOLPP1 FUT7 FCN2	2.66e-03	325	39	3	chr9q34
Cytoband	9q34.3	FUT7 FCN2	3.70e-03	106	39	2	9q34.3
Cytoband	19q13.33	SIGLEC11 TMEM143	3.70e-03	106	39	2	19q13.33
GeneFamily	Type 1 receptor serine/threonine kinases	TGFBR1 ACVR1C	4.16e-05	7	26	2	345
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RCOR3 CHD6	2.62e-03	53	26	2	532
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PACSIN3 TGFBR1 GPR88 GRM2	7.38e-06	143	39	4	36ce6f163fb33141c86288086c354b91853fad25
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ACVR1C GPR88 GRM2 PRSS16	8.45e-06	148	39	4	223d6a640f3c34e73646a615593b9c0b4a4cbd6f
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Lrrtm2_(Cadm2_state)\|Thalamus / BrainAtlas - Mouse McCarroll V32	DUOX1 FUT7 PRSS16	8.91e-06	46	39	3	61ce3bd406d297b62de88e5fd2262cf28b966645
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PACSIN3 TGFBR1 GPR88 GRM2	1.09e-05	158	39	4	c8af8964a140acb2987e3b4906d72c546108d229
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PACSIN3 TGFBR1 GPR88 GRM2	1.46e-05	170	39	4	67415b098e8ba815b501e557192a9f2b10ee995a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENAM DUOX1 FUT7 IL3RA	1.53e-05	172	39	4	d40a8bd61114b49a5837c836136a13c37c8f7de0
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ENAM TGFBR1 FUT7 IL3RA	1.64e-05	175	39	4	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	COPD-Myeloid-pDC\|COPD / Disease state, Lineage and Cell class	ENAM TGFBR1 FUT7 IL3RA	1.71e-05	177	39	4	415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell	facs-Marrow-T-cells-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACVR1C FUT7 IL3RA TECPR1	1.75e-05	178	39	4	41745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCell	facs-Marrow-T-cells-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACVR1C FUT7 IL3RA TECPR1	1.75e-05	178	39	4	eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TGFBR1 CHD9 MMP28	2.50e-05	195	39	4	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	Biopsy_Control_(H.)-Epithelial-Transitional_AT2\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	PACSIN3 DUOX1 ITGA3 MMP28	2.71e-05	199	39	4	e04a57a55c724091db353e2b3baf84372d788728
ToppCell	Sepsis-Int-URO-Myeloid-pDC\|Int-URO / Disease, condition lineage and cell class	ENAM TMED9 FUT7 IL3RA	2.71e-05	199	39	4	a41c3c3360b1b4546c9b2c49bda595feef6a4a4a
ToppCell	Sepsis-URO-Myeloid-pDC\|URO / Disease, condition lineage and cell class	ENAM CHD9 FUT7 IL3RA	2.71e-05	199	39	4	1dc96a1cc313fa175fe50f0df606baa84ea5970b
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ACVR1C GPR88 PRSS16	4.21e-05	77	39	3	a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; HL60; HG-U133A	CHD9 TMED9 MLF2 ACACA SNX1 KTN1	8.61e-07	192	39	6	1778_DN
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD8 CHD6	6.33e-08	7	37	3	DOID:0050834 (implicated_via_orthology)
Disease	Colorectal Carcinoma	LRP1 TGFBR1 MLF2 VPS18 ZSCAN16 LZTS2 ACACA FCN2	2.07e-06	702	37	8	C0009402
Disease	phenylketonuria (implicated_via_orthology)	HNF1A DUOX1	9.17e-06	4	37	2	DOID:9281 (implicated_via_orthology)
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	1.53e-05	5	37	2	DOID:0080000 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	CHD9 CHD8 CHD6	8.98e-05	69	37	3	DOID:1682 (implicated_via_orthology)
Disease	level of Sterol ester (27:1/18:1) in blood serum	HNF1A CLASRP	1.82e-04	16	37	2	OBA_2045195
Disease	alpha fetoprotein measurement	USP34 CHD9 HNF1A	2.70e-04	100	37	3	EFO_0010583
Disease	kidney disease (biomarker_via_orthology)	TGFBR1 HNF1A	3.16e-04	21	37	2	DOID:557 (biomarker_via_orthology)
Disease	level of Sterol ester (27:1/18:2) in blood serum	HNF1A CLASRP	4.88e-04	26	37	2	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	HNF1A CLASRP	4.88e-04	26	37	2	OBA_2045191
Disease	macrophage inflammatory protein 1b measurement	ACACA GRM2 MMP28	6.63e-04	136	37	3	EFO_0008219
Disease	fatty liver disease (implicated_via_orthology)	ACACA ACACB	6.95e-04	31	37	2	DOID:9452 (implicated_via_orthology)
Disease	Squamous cell carcinoma of lung	ANKK1 ACVR1C	7.41e-04	32	37	2	C0149782
Disease	autism spectrum disorder (implicated_via_orthology)	CHD9 CHD8 CHD6	9.16e-04	152	37	3	DOID:0060041 (implicated_via_orthology)
Disease	fibrinogen measurement, coronary artery disease	CHD9 HNF1A TSPAN14	9.51e-04	154	37	3	EFO_0001645, EFO_0004623
Disease	fibrinogen measurement, tissue plasminogen activator measurement	CHD9 HNF1A	1.46e-03	45	37	2	EFO_0004623, EFO_0004791
Disease	non-high density lipoprotein cholesterol measurement	ENAM USP34 HNF1A TSPAN14 ACVR1C	1.87e-03	713	37	5	EFO_0005689
Disease	Ischemic stroke, fibrinogen measurement	CHD9 HNF1A	2.18e-03	55	37	2	EFO_0004623, HP_0002140
Disease	Alzheimer's disease (implicated_via_orthology)	LRP1 RCOR3	2.34e-03	57	37	2	DOID:10652 (implicated_via_orthology)
Disease	blood urea nitrogen measurement	CHD9 RCOR3 HNF1A TSPAN14	2.41e-03	452	37	4	EFO_0004741
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	HNF1A TSPAN14	2.85e-03	63	37	2	EFO_0001645, EFO_0004792
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACA ACACB	3.03e-03	65	37	2	DOID:0080208 (biomarker_via_orthology)
Disease	venous thromboembolism, fibrinogen measurement	CHD9 HNF1A	3.21e-03	67	37	2	EFO_0004286, EFO_0004623
Disease	tissue plasminogen activator measurement, coronary artery disease	HNF1A TSPAN14	3.60e-03	71	37	2	EFO_0001645, EFO_0004791
Disease	alcohol consumption measurement	ANKK1 RCOR3 MLF2 HNF1A ACACA ACACB	4.17e-03	1242	37	6	EFO_0007878
Disease	Schizophrenia	LRP1 ANKK1 GRM2 PRSS16 IL3RA	4.68e-03	883	37	5	C0036341
Disease	complex trait	HNF1A CHD6 ZSCAN16	4.73e-03	271	37	3	EFO_0010578

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRWTRREQTDFYRVV	CHD8	1796	Q9HCK8
VFQARHRRWRTEYAI	ANKK1	36	Q8NFD2
REFWEQRFRCSFRQR	GRM2	346	Q14416
SRDERSWFREAEIYQ	ACVR1C	226	Q8NER5
SIRRWSYEMFRNERA	ACACA	136	Q13085
YRRRFNLEEVLQEWE	RCOR3	331	Q9P2K3
RWAYEMFRNERAIRF	ACACB	281	O00763
VRLRDGDRYWFENTR	DUOX1	506	Q9NRD9
VRRTEFYFAQARWRL	KIAA0100	1906	Q14667
YTWRNEEFRRSVRSV	GPR88	336	Q9GZN0
QAYEERQRHWQRERE	LZTS2	356	Q9BRK4
WFEYTVTRAEARNRQ	DOLPP1	216	Q86YN1
DYDAREQRVYWSDVR	LRP1	1621	Q07954
DYRDFDRVRVNGWAT	ITGA3	941	P26006
NESRYQRFFAWRDRL	FUT7	291	Q11130
EVRVYNWFANRRKEE	HNF1A	261	P20823
QEAERRWEEVQSYIR	KTN1	491	Q86UP2
QRWTRREEADFYRVV	CHD9	1836	Q3L8U1
QIRARERVYEFLSAW	IL3RA	271	P26951
AQKRWTRREQADFYR	CHD6	1446	Q8TD26
QRRVDGSVDFYRDWA	FCN2	146	Q15485
RERRPYFNRNIWDQA	ENAM	776	Q9NRM1
AFDDEWRRETSRFRQ	MLF2	191	Q15773
FWEAGNYRRTVQRVE	PACSIN3	16	Q9UKS6
SIIFFRDDRYWRLDQ	MMP28	476	Q9H239
EWNRDVQYRGRVRVQ	SRP19	71	P09132
SREERSWFREAEIYQ	TGFBR1	236	P36897
EKEREEWERQYSRQS	CLASRP	631	Q8N2M8
EQNYQRWREERFRQT	TMED9	181	Q9BVK6
REPRDWAQQYRERFI	TMEM143	61	Q96AN5
WESRVTQYERDFERI	SNX1	456	Q13596
WQSRNERYQAEGYRR	STYXL2	396	Q5VZP5
RRREEAYENQRWNPM	TECPR1	66	Q7Z6L1
VFRYHVQREARDVWR	VPS18	386	Q9P253
YEQVREWFAERQRRS	ZHX1	811	Q9UKY1
SEWQQRERRRYKCDE	ZSCAN16	226	Q9H4T2
LAFLFQDWVRDRFRE	TSPAN14	111	Q8NG11
EAFRRRFAYHLRQWQ	USP34	1176	Q70CQ2
VSDRRSFLQRYWVND	PRSS16	71	Q9NQE7
EAWYFFRVERGSRVR	SIGLEC11	126	Q96RL6