Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfour-way junction DNA binding

RAD51C RAD51D WRN BLM

4.34e-06191194GO:0000400
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

RAD51C RAD51D WRN CHD9 BTAF1 BLM SHPRH

1.11e-051271197GO:0008094
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

RAD51C RAD51D ERCC4 WRN CHD9 BTAF1 BLM MAP1S SHPRH

2.77e-052621199GO:0140097
GeneOntologyMolecularFunctionforked DNA-dependent helicase activity

WRN BLM

3.52e-0521192GO:0061749
GeneOntologyMolecularFunctionDNA secondary structure binding

RAD51C RAD51D WRN BLM

1.02e-04411194GO:0000217
GeneOntologyMolecularFunction8-hydroxy-2'-deoxyguanosine DNA binding

WRN BLM

1.05e-0431192GO:1905773
GeneOntologyMolecularFunctiontelomeric G-quadruplex DNA binding

WRN BLM

1.05e-0431192GO:0061849
GeneOntologyMolecularFunctionY-form DNA binding

WRN BLM

2.10e-0441192GO:0000403
GeneOntologyMolecularFunctiontelomeric D-loop binding

WRN BLM

2.10e-0441192GO:0061821
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

IPO7 RAPGEF4 OBSCN ADGRB3 RABGAP1 PLEKHG4B SGSM2 HPS1 TBCK GPSM2 PREX1

2.27e-0450711911GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

IPO7 RAPGEF4 OBSCN ADGRB3 RABGAP1 PLEKHG4B SGSM2 HPS1 TBCK GPSM2 PREX1

2.27e-0450711911GO:0030695
GeneOntologyMolecularFunctionD-loop DNA binding

WRN BLM

5.20e-0461192GO:0062037
GeneOntologyMolecularFunctionfour-way junction helicase activity

WRN BLM

5.20e-0461192GO:0009378
GeneOntologyMolecularFunctionbubble DNA binding

WRN BLM

9.63e-0481192GO:0000405
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD9 BTAF1 SHPRH

1.38e-03371193GO:0140658
GeneOntologyMolecularFunctionglutamate receptor binding

RAPSN PTK2B PTPN4 DNM3

1.40e-03811194GO:0035254
GeneOntologyMolecularFunctionoxidized purine DNA binding

WRN BLM

1.54e-03101192GO:0032357
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

RAD51C RAD51D ERCC4 THUMPD3 WRN CHD9 BTAF1 LCMT2 BLM MAP1S SHPRH

1.65e-0364511911GO:0140640
GeneOntologyMolecularFunctiontelomeric DNA binding

WRN SMG5 BLM

1.74e-03401193GO:0042162
GeneOntologyMolecularFunctionoxidized DNA binding

WRN BLM

1.87e-03111192GO:0032356
GeneOntologyBiologicalProcessgamma-delta T cell differentiation

STAT5A STAT5B JAG2 SCART1

4.75e-06201194GO:0042492
GeneOntologyBiologicalProcessmitotic recombination

RAD51C RAD51D ERCC4 BLM

1.67e-05271194GO:0006312
GeneOntologyBiologicalProcessgamma-delta T cell activation

STAT5A STAT5B JAG2 SCART1

3.79e-05331194GO:0046629
GeneOntologyBiologicalProcesspositive regulation of natural killer cell activation

IL12A STAT5A STAT5B HPS1

4.80e-05351194GO:0032816
GeneOntologyBiologicalProcesslymphocyte differentiation

IL12A STAT5A STAT5B BLM JAG2 PTK2B RSAD2 LMBR1L SCART1 TNFAIP3 PREX1 IL7R

6.50e-0553711912GO:0030098
GeneOntologyBiologicalProcessT cell differentiation

IL12A STAT5A STAT5B BLM JAG2 RSAD2 LMBR1L SCART1 PREX1 IL7R

7.49e-0538211910GO:0030217
GeneOntologyBiologicalProcesstelomere maintenance via recombination

RAD51C RAD51D ERCC4

8.10e-05151193GO:0000722
GeneOntologyBiologicalProcessmononuclear cell differentiation

IL12A THOC5 STAT5A STAT5B BLM JAG2 PTK2B RSAD2 LMBR1L SCART1 TNFAIP3 PREX1 IL7R

8.39e-0564011913GO:1903131
GeneOntologyBiologicalProcessdevelopment of secondary male sexual characteristics

STAT5A STAT5B

9.86e-0531192GO:0046544
GeneOntologyBiologicalProcessluteinization

STAT5A STAT5B PTPRN

9.93e-05161193GO:0001553
DomainRQC

WRN BLM

3.96e-0521182SM00956
DomainTRPV5/TRPV6

TRPV6 TRPV5

3.96e-0521182IPR008344
DomainPTPc

PTPRT PTPN4 PTPN14 PTPRN

7.63e-05361184SM00194
DomainTYR_PHOSPHATASE_PTP

PTPRT PTPN4 PTPN14 PTPRN

1.05e-04391184PS50055
DomainTPR-like_helical_dom

ADCY10 RAPSN TTC28 TTC39C SMG5 CCNF CFAP54 GPSM2

1.17e-042331188IPR011990
Domain-

WRN BLM

1.18e-04311821.10.150.80
DomainHRDC

WRN BLM

1.18e-0431182SM00341
DomainGPCR_2_brain_angio_inhib

ADGRB2 ADGRB3

1.18e-0431182IPR008077
DomainRQC_domain

WRN BLM

1.18e-0431182IPR018982
DomainHRDC

WRN BLM

1.18e-0431182PS50967
DomainRQC

WRN BLM

1.18e-0431182PF09382
DomainHRDC

WRN BLM

1.18e-0431182PF00570
DomainPTPase_domain

PTPRT PTPN4 PTPN14 PTPRN

1.28e-04411184IPR000242
DomainY_phosphatase

PTPRT PTPN4 PTPN14 PTPRN

1.28e-04411184PF00102
DomainLRRC37AB_C

LRRC37A2 LRRC37A

2.36e-0441182IPR029423
DomainHRDC_dom

WRN BLM

2.36e-0441182IPR002121
DomainRecQ_Zn_bind

WRN BLM

2.36e-0441182PF16124
DomainLRRC37AB_C

LRRC37A2 LRRC37A

2.36e-0441182PF14914
DomainRecQ_Zn-bd

WRN BLM

2.36e-0441182IPR032284
DomainLRRC37_N

LRRC37A2 LRRC37A

2.36e-0441182IPR032754
DomainLRRC37

LRRC37A2 LRRC37A

2.36e-0441182PF15779
DomainLRRC37A/B-like

LRRC37A2 LRRC37A

2.36e-0441182IPR015753
Domain-

ADCY10 RAPSN TTC28 TTC39C CCNF CFAP54 GPSM2

3.46e-0420711871.25.40.10
DomainHRDC-like

WRN BLM

3.91e-0451182IPR010997
DomainDNA_helicase_ATP-dep_RecQ

WRN BLM

3.91e-0451182IPR004589
DomainPTPc_motif

PTPRT PTPN4 PTPN14 PTPRN

5.27e-04591184SM00404
DomainTyr_Pase_cat

PTPRT PTPN4 PTPN14 PTPRN

5.27e-04591184IPR003595
DomainRad51_DMC1_RadA

RAD51C RAD51D

5.84e-0461182IPR033925
DomainDNA_recomb/repair_RecA-like

RAD51C RAD51D

5.84e-0461182IPR016467
DomainHelicase_C

WRN CHD9 BTAF1 BLM SHPRH

5.88e-041071185PF00271
DomainHELICc

WRN CHD9 BTAF1 BLM SHPRH

5.88e-041071185SM00490
DomainHelicase_C

WRN CHD9 BTAF1 BLM SHPRH

6.14e-041081185IPR001650
DomainHELICASE_CTER

WRN CHD9 BTAF1 BLM SHPRH

6.40e-041091185PS51194
DomainHELICASE_ATP_BIND_1

WRN CHD9 BTAF1 BLM SHPRH

6.40e-041091185PS51192
DomainDEXDc

WRN CHD9 BTAF1 BLM SHPRH

6.40e-041091185SM00487
DomainHelicase_ATP-bd

WRN CHD9 BTAF1 BLM SHPRH

6.67e-041101185IPR014001
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

8.14e-0471182IPR012345
DomainSTAT

STAT5A STAT5B

8.14e-0471182IPR001217
DomainDNA_recomb/repair_Rad51_C

RAD51C RAD51D

8.14e-0471182IPR013632
DomainSTAT_int

STAT5A STAT5B

8.14e-0471182SM00964
DomainRecA_ATP-bd

RAD51C RAD51D

8.14e-0471182IPR020588
DomainRECA_2

RAD51C RAD51D

8.14e-0471182PS50162
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

8.14e-0471182IPR013801
DomainSTAT_bind

STAT5A STAT5B

8.14e-0471182PF02864
DomainSTAT_int

STAT5A STAT5B

8.14e-0471182PF02865
Domain-

STAT5A STAT5B

8.14e-04711821.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

8.14e-0471182PF01017
Domain-

STAT5A STAT5B

8.14e-04711821.20.1050.20
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

8.14e-0471182IPR013799
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

8.14e-0471182IPR015988
Domain-

STAT5A STAT5B

8.14e-04711822.60.40.630
DomainRad51

RAD51C RAD51D

8.14e-0471182PF08423
DomainSNF2_N

CHD9 BTAF1 SHPRH

1.07e-03321183IPR000330
DomainSNF2_N

CHD9 BTAF1 SHPRH

1.07e-03321183PF00176
DomainSTAT_TF_alpha

STAT5A STAT5B

1.08e-0381182IPR013800
DomainTyr_Pase_AS

PTPRT PTPN4 PTPN14 PTPRN

1.18e-03731184IPR016130
DomainPH_dom-like

OBSCN RABGAP1 PLEKHG4B SPTBN5 PTK2B PTPN4 PTPN14 DNM3 PREX1

1.54e-034261189IPR011993
DomainTPR_7

TTC28 GPSM2

1.72e-03101182PF13176
DomainTRP_channel

TRPV6 TRPV5

2.10e-03111182IPR004729
DomainGAIN_dom_N

ADGRB2 ADGRB3

2.10e-03111182IPR032471
DomainGAIN

ADGRB2 ADGRB3

2.10e-03111182PF16489
DomainTYR_PHOSPHATASE_1

PTPRT PTPN4 PTPN14 PTPRN

2.16e-03861184PS00383
DomainTYR_PHOSPHATASE_dom

PTPRT PTPN4 PTPN14 PTPRN

2.25e-03871184IPR000387
DomainTYR_PHOSPHATASE_2

PTPRT PTPN4 PTPN14 PTPRN

2.25e-03871184PS50056
Domain-

RAPGEF4 WRN BLM SHPRH EIF3A PREX1

2.63e-0321811861.10.10.10
Domain-

PTPRT PTPN4 PTPN14 PTPRN

2.76e-039211843.90.190.10
DomainFERM_M

PTK2B PTPN4 PTPN14

3.06e-03461183PF00373
Domain-

OBSCN RABGAP1 PLEKHG4B SPTBN5 PTPN4 PTPN14 DNM3 PREX1

3.40e-0339111882.30.29.30
DomainProt-tyrosine_phosphatase-like

PTPRT PTPN4 PTPN14 PTPRN

3.59e-03991184IPR029021
Domain-

PTK2B PTPN4 PTPN14

3.67e-034911831.20.80.10
DomainTBC

RABGAP1 SGSM2 TBCK

3.67e-03491183SM00164
DomainFERM_central

PTK2B PTPN4 PTPN14

3.67e-03491183IPR019748
DomainFERM_domain

PTK2B PTPN4 PTPN14

3.67e-03491183IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTK2B PTPN4 PTPN14

3.88e-03501183IPR014352
DomainFERM_1

PTK2B PTPN4 PTPN14

3.88e-03501183PS00660
DomainFERM_2

PTK2B PTPN4 PTPN14

3.88e-03501183PS00661
DomainFERM_3

PTK2B PTPN4 PTPN14

3.88e-03501183PS50057
DomainBand_41_domain

PTK2B PTPN4 PTPN14

3.88e-03501183IPR019749
DomainB41

PTK2B PTPN4 PTPN14

3.88e-03501183SM00295
DomainWHTH_DNA-bd_dom

RAPGEF4 WRN BLM SHPRH EIF3A PREX1

4.39e-032421186IPR011991
DomainQuinoprotein_ADH-like_supfam

CFAP251 WDR86 EIF2AK3

4.58e-03531183IPR011047
DomainRabGAP-TBC

RABGAP1 SGSM2 TBCK

4.58e-03531183PF00566
DomainRab-GTPase-TBC_dom

RABGAP1 SGSM2 TBCK

5.08e-03551183IPR000195
DomainTBC_RABGAP

RABGAP1 SGSM2 TBCK

5.08e-03551183PS50086
DomainIon_trans_dom

HCN3 RYR2 TRPV6 TRPV5

5.93e-031141184IPR005821
DomainIon_trans

HCN3 RYR2 TRPV6 TRPV5

5.93e-031141184PF00520
DomainVWC_out

JAG2 NELL1

6.31e-03191182SM00215
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B PTK2B IL7R

2.22e-0616864M1296
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B PTK2B IL7R

2.22e-0616864MM1420
PathwayWP_IL7_SIGNALING

STAT5A STAT5B PTK2B IL7R

1.48e-0525864M39499
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

RAD51C RAD51D WRN BLM

1.74e-0526864MM15297
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA

RAD51C RAD51D WRN BLM

2.04e-0527864M27586
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B PTK2B

2.55e-0510863MM15618
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B PTK2B

4.63e-0512863M27893
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES

RAD51C RAD51D WRN BLM

5.85e-0535864MM15293
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES

RAD51C RAD51D WRN BLM

7.31e-0537864M27583
PathwayREACTOME_HOMOLOGY_DIRECTED_REPAIR

RAD51C RAD51D ERCC4 WRN BLM PIAS4

7.50e-05116866MM15294
PathwayWP_FOXP3_IN_COVID19

STAT5A STAT5B IL7R

9.46e-0515863M42573
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B IL7R

9.46e-0515863MM14536
PathwayWP_8Q1123_RB1CC1_COPY_NUMBER_VARIATION

ATG101 RB1CC1 PTK2B

1.16e-0416863M48107
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

RAD51C RAD51D WRN BLM

1.33e-0443864M27588
PathwayWP_IL7_SIGNALING_PATHWAY

STAT5A STAT5B PTK2B IL7R

1.33e-0443864MM15864
PathwayKEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY

IL12A STAT5A STAT5B IL7R

1.59e-0445864M47408
PathwayREACTOME_HOMOLOGY_DIRECTED_REPAIR

RAD51C RAD51D ERCC4 WRN BLM PIAS4

2.11e-04140866M27584
PathwayREACTOME_DISEASES_OF_DNA_REPAIR

RAD51C RAD51D WRN BLM

2.59e-0451864M29854
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

RAD51C RAD51D ERCC4 WRN BLM PIAS4

2.65e-04146866MM15292
PathwayKEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B IL7R

3.55e-0423863M47904
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.64e-045862M48987
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.64e-045862M48986
PathwayKEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

3.64e-045862M49006
PathwayREACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR

RAD51C RAD51D WRN BLM

4.55e-0459864MM15283
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

5.43e-046862MM15581
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

5.43e-046862MM15621
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

RAD51C RAD51D ERCC4 WRN BLM PIAS4

5.97e-04170866M27582
PathwayKEGG_HOMOLOGOUS_RECOMBINATION

RAD51C RAD51D BLM

6.43e-0428863M11675
PathwayREACTOME_STAT5_ACTIVATION

STAT5A STAT5B

7.57e-047862M27953
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

7.57e-047862M47581
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

7.57e-047862M47646
PathwayKEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

7.57e-047862M47430
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

STAT5A STAT5B

7.57e-047862M27907
PathwayREACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR

RAD51C RAD51D WRN BLM

8.71e-0470864M27570
PathwayKEGG_MEDICUS_REFERENCE_C9ORF72_MEDIATED_AUTOPHAGY_INITIATION

ATG101 RB1CC1

1.01e-038862M47746
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

PIAS4 CYP2R1

1.01e-038862MM14766
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

WRN BLM PIAS4 NUP210

1.25e-0377864M27226
PathwayREACTOME_INTERLEUKIN_2_FAMILY_SIGNALING

STAT5A STAT5B PTK2B

1.25e-0335863MM15144
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

1.29e-039862M27861
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

1.29e-039862MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

1.29e-039862M8066
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

ERCC4 WRN BLM

1.35e-0336863MM15281
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B IL7R

1.35e-0336863M542
PathwayWP_MEASLES_VIRUS_INFECTION

IL12A STAT5A STAT5B TNFAIP3 EIF2AK3

1.45e-03136865M42547
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

ERCC4 WRN BLM

1.47e-0337863M27568
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

1.60e-0310862M27898
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

STAT5A STAT5B

1.60e-0310862M41731
PathwayREACTOME_SIGNALING_BY_LEPTIN

STAT5A STAT5B

1.95e-0311862M27195
PathwayKEGG_MEDICUS_REFERENCE_RAD51_DSDNA_DESTABILIZATION

RAD51C RAD51D

1.95e-0311862M47894
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B

1.95e-0311862MM15578
PathwayWP_IL2_SIGNALING

STAT5A STAT5B PTK2B

2.12e-0342863M39536
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

PIAS4 CYP2R1

2.33e-0312862M27088
PathwayREACTOME_DNA_REPAIR

RAD51C RAD51D ERCC4 PARG WRN BLM PIAS4

2.40e-03301867MM15433
PathwayREACTOME_INTERLEUKIN_2_FAMILY_SIGNALING

STAT5A STAT5B PTK2B

2.42e-0344863M1012
PathwayKEGG_JAK_STAT_SIGNALING_PATHWAY

IL12A STAT5A STAT5B PIAS4 IL7R

2.57e-03155865M17411
Pubmed

Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes.

STAT5A STAT5B IL7R

1.68e-074122316273100
Pubmed

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

STAT5A STAT5B IL7R

1.68e-07412237719938
Pubmed

STAT5 activation underlies IL7 receptor-dependent B cell development.

STAT5A STAT5B IL7R

1.68e-074122315067053
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MON2 SZT2 UBE3B OBSCN ADGRB2 BTAF1 SMG5 PTCH1 TINAGL1 JAG2 PIAS4 MAP1S SGSM2 ANKRD11 AP1G2 TNFAIP3 PREX1

3.39e-0711051221735748872
Pubmed

Stat5a/b are essential for normal lymphoid development and differentiation.

STAT5A STAT5B IL7R

4.19e-075122316418296
Pubmed

Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101.

ATG101 RB1CC1 PTCH1

4.19e-075122329453315
Pubmed

Direct interaction between Kit and the interleukin-7 receptor.

STAT5A STAT5B IL7R

4.19e-075122317554063
Pubmed

Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).

RAD51C RAD51D BLM

4.19e-075122312975363
Pubmed

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

STAT5A STAT5B IL7R

1.46e-067122310490100
Pubmed

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

STAT5A STAT5B IL7R

3.48e-069122319946273
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DNAJC13 OBSCN CHD9 BTAF1 RABGAP1 ATP10A STT3A STAT5B JAG2 PLEKHG4B PIAS4 PTPN4 HOXB6 SGSM2 NUP210 TBCK SHPRH ANKRD11

4.60e-0614891221828611215
Pubmed

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

STAT5A STAT5B IL7R

4.96e-0610122320974963
Pubmed

c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.

STAT5A STAT5B IL7R

4.96e-0610122332103006
Pubmed

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

STAT5A STAT5B IL7R

4.96e-0610122317182565
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

IPPK PTCH1 ZBTB24 MFAP2 DNM3 DLEU7 EIF2AK3

6.72e-06198122720881960
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PTCH1 MFAP2 PTPN14 DNM3 DLEU7 EIF2AK3

8.92e-06136122625429064
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TTC28 RAPGEF4 ADGRB3 HLCS CHD9 OAT SMG5 STAT5B NELL1 MAP1S SGSM2 GLUL DNM3 DLEU7 GPSM2 PREX1

1.14e-0512851221635914814
Pubmed

STAT5 is required for thymopoiesis in a development stage-specific manner.

STAT5A STAT5B IL7R

1.17e-0513122315294943
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

1.22e-052122223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

1.22e-052122226999798
Pubmed

Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity.

RB1CC1 PIAS4

1.22e-052122218285457
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

1.22e-052122231443474
Pubmed

Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.

TRPV6 TRPV5

1.22e-052122220178461
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

1.22e-052122212377952
Pubmed

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.

TRPV6 TRPV5

1.22e-052122222354706
Pubmed

Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.

TRPV6 TRPV5

1.22e-052122216564089
Pubmed

Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.

TRPV6 TRPV5

1.22e-052122219295174
Pubmed

Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.

TRPV6 TRPV5

1.22e-052122223968883
Pubmed

Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.

TRPV6 TRPV5

1.22e-052122212390878
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

1.22e-052122221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

1.22e-052122216289657
Pubmed

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

WRN BLM

1.22e-052122217115688
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

1.22e-052122225552366
Pubmed

Attenuation of IL-7 receptor signaling is not required for allelic exclusion.

STAT5B IL7R

1.22e-052122216517702
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

1.22e-052122225470773
Pubmed

TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.

TRPV6 TRPV5

1.22e-052122230916584
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

1.22e-052122221431790
Pubmed

Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.

PTCH1 BLM

1.22e-052122219995795
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

1.22e-052122228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

1.22e-052122221826656
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

1.22e-05212227720707
Pubmed

Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.

RAD51C RAD51D

1.22e-052122233657816
Pubmed

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.

TRPV6 TRPV5

1.22e-052122216565876
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

1.22e-052122227264955
Pubmed

Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

RAD51C RAD51D

1.22e-052122226057125
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

1.22e-052122222159083
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

1.22e-052122220008792
Pubmed

Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.

ADGRB2 ADGRB3

1.22e-052122212218411
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

1.22e-052122233199496
Pubmed

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.

WRN BLM

1.22e-052122211919194
Pubmed

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.

TRPV6 TRPV5

1.22e-052122216705151
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

1.22e-052122216502315
Pubmed

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.

WRN BLM

1.22e-052122218028256
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

1.22e-052122212217382
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

1.22e-052122231599926
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

1.22e-052122210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

1.22e-052122221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

1.22e-052122210486277
Pubmed

Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.

TRPV6 TRPV5

1.22e-052122220405023
Pubmed

Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.

STAT5B PTPRN

1.22e-052122216622421
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

1.22e-052122216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

1.22e-052122215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

1.22e-052122230377054
Pubmed

A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.

TRPV6 TRPV5

1.22e-052122211846401
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

1.22e-052122223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

1.22e-052122232790723
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

1.22e-052122218492722
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

1.22e-052122210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

1.22e-052122210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

1.22e-052122235464049
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

1.22e-052122218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

1.22e-052122223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

1.22e-05212228631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

1.22e-052122211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

1.22e-052122224878107
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

1.22e-052122212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

1.22e-052122212835478
Pubmed

Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.

TRPV6 TRPV5

1.22e-052122224761864
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

1.22e-05212227568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

1.22e-052122224497979
Pubmed

Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.

RB1CC1 PTK2B

1.22e-052122221602932
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

1.22e-052122217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

1.22e-052122217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

1.22e-052122217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

1.22e-052122210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

1.22e-052122217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

1.22e-052122224497923
Pubmed

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

WRN BLM

1.22e-052122210871376
Pubmed

Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.

TRPV6 TRPV5

1.22e-052122212077127
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

1.22e-052122224335105
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

1.22e-052122229460051
Pubmed

A decade of RAD51C and RAD51D germline variants in cancer.

RAD51C RAD51D

1.22e-052122234923718
Pubmed

[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].

TRPV6 TRPV5

1.22e-052122224592736
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

1.22e-052122228606561
Pubmed

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.

WRN BLM

1.22e-052122226195664
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

1.22e-052122212393407
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

1.22e-052122212039059
Pubmed

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.

STAT5A STAT5B

1.22e-052122221178171
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

1.22e-052122220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

1.22e-052122216775227
GeneFamilyAdhesion G protein-coupled receptors, subfamily B

ADGRB2 ADGRB3

4.30e-053692912
GeneFamilyRecQ like helicases

WRN BLM

1.42e-0456921049
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTK2B PTPN4 PTPN14

9.17e-04506931293
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN4 PTPN14

2.11e-0318692812
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

RAD51C ERCC4

2.61e-0320692548
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRT PTPRN

2.88e-0321692813
GeneFamilyTransient receptor potential cation channels

TRPV6 TRPV5

5.09e-0328692249
GeneFamilyAutophagy related

ATG101 RB1CC1

7.02e-03336921022
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC28 TTC39C GPSM2

9.69e-03115693769
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CERK GPR65 TTC39C PTPN4 SCART1 WDR86 TNFAIP3 IL7R

3.51e-081821208f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCellCOVID-19_Severe-Lymphoid_T/NK-MAIT|COVID-19_Severe / Disease group, lineage and cell class

CERK GPR65 TTC39C PTPN4 SCART1 WDR86 TNFAIP3 IL7R

3.51e-08182120819045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CERK GPR65 TTC39C PTPN4 SCART1 WDR86 TNFAIP3 IL7R

3.51e-081821208cccac9f85825f4e310b86e37ee6320769a670501
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CERK GPR65 TTC39C PTPN4 SCART1 WDR86 TNFAIP3 IL7R

3.51e-0818212081444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CERK GPR65 TTC39C PTPN4 SCART1 WDR86 TNFAIP3 IL7R

3.51e-08182120849eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CERK GPR65 TTC39C PTCH1 PTPN4 RSAD2 TNFAIP3 IL7R

7.00e-081991208cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like|bone_marrow / Manually curated celltypes from each tissue

CERK GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

4.20e-0717112072977cffc146470733b5cfd8a1aa80d9346d4804d
ToppCellCOVID-19_Severe-MAIT|COVID-19_Severe / Disease condition and Cell class

CERK GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

5.30e-0717712078eb69041f482b58325e3539f607923f7b1fa5977
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-MAIT|bone_marrow / Manually curated celltypes from each tissue

CERK GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

5.50e-0717812077ac71e245864be2e8daecf555ff68235bd05827c
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TTC39C ATP10A MED12L SCART1 TNFAIP3 PREX1 IL7R

6.39e-0718212076bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2 IL7R

7.39e-0718612077278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILC3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GPR65 TTC39C PTPN4 SCART1 TNFAIP3 PREX1 IL7R

7.67e-071871207a037631a01d2cce088e6522dceeb1eee806522a1
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C ATP10A NUP210 SCART1 TNFAIP3 IL7R

7.67e-07187120742b20d7f0a4f9195b3d71dc0e089b5e0914ebcbb
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like|bone_marrow / Manually curated celltypes from each tissue

CERK GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

8.23e-071891207ac2995e599f3d1813218479dc515b1d612c0ef8b
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

CERK GPR65 TTC39C IFFO2 SCART1 TNFAIP3 IL7R

8.53e-0719012070c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-MAIT|bone_marrow / Manually curated celltypes from each tissue

CERK GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

8.83e-0719112077a28905ad504979497836e87df81d529e675ce78
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

CERK TTC39C RYR2 STAT5B MED12L TNFAIP3 IL7R

1.01e-0619512076687e579582d7a239bee80846de0cf827a6f6a62
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-MAIT|COVID-19_Severe / Disease, condition lineage and cell class

CERK GPR65 TTC39C PTPN4 WDR86 TNFAIP3 IL7R

1.20e-062001207b8cfccecff9900aee323c40e771c94e560b8c488
ToppCellcontrol-MAIT|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CERK GPR65 TTC39C PTCH1 PTPN4 TNFAIP3 IL7R

1.20e-062001207aeea4bda2e38cc6db571ed2b47ce022d637619bd
ToppCellsevere-MAIT|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CERK GPR65 TTC39C PTPN4 WDR86 TNFAIP3 IL7R

1.20e-0620012071daf43f1bdd49585dce5e957820554d7f3c1bd4a
ToppCellTCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9

RAPGEF4 WRN CHD9 BTAF1 LCMT2 CROT

1.80e-061351206ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|356C / Donor, Lineage, Cell class and subclass (all cells)

SPATA6L PTCH1 PTPN4 LRRC37A CYP2R1 SGSM2

4.64e-0615912062fb1d2ff52920aeb48d048cf29f0cd45f944a73d
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

CHST6 PLEKHG4B AXDND1 MFAP2 CFAP54 PTPRN

5.55e-0616412069b4a6007abae992db871d9f6f731d5af724de30d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A PLEKHG4B SPTBN5 IL7R

8.31e-06176120603d194c9814e12802cd932afade69e868814cb78
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C SCART1 TNFAIP3 PREX1 IL7R

8.31e-061761206238244294d08975df6bfa26b2b437db3654408ae
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAD51C TICRR ERCC4 ATP10A BLM GPSM2

8.58e-0617712061d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A PLEKHG4B SPTBN5 IL7R

8.86e-061781206a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A PLEKHG4B SPTBN5 IL7R

9.44e-0618012067a9aa96fb8035020640cc7d3df0c41c730516c6f
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GPR65 ATP10A NUP210 MED12L SCART1 IL7R

1.07e-0518412063e9d75af578297950e469f23fb2d28393a2feef8
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-MAIT_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C SCART1 WDR86 TNFAIP3 IL7R

1.10e-0518512068314dc608bc837df3037e89afd9db39737374ebc
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GPR65 PTPN4 SCART1 WDR86 TNFAIP3 IL7R

1.17e-051871206f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPXM2 OAT JAG2 PTPN14 GLUL TNFAIP3

1.17e-0518712069c1013720c248ef201d010806b6e7ad24205e8ee
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.17e-051871206e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.17e-05187120624cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.17e-0518712062f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MON2 BTAF1 RB1CC1 ANKRD11 TNFAIP3 EIF2AK3

1.21e-051881206ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPATA6L STK32B PTPRT CFAP54 PTPN14 DNM3

1.21e-05188120663a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

STK32B NELL1 PTPN4 PTPN14 LINGO1 DNM3

1.25e-051891206830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGRB3 PTCH1 RYR2 NELL1 GPSM2 WDR86

1.25e-0518912062a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT|lymph-node_spleen / Manually curated celltypes from each tissue

CERK GPR65 TTC39C SCART1 TNFAIP3 IL7R

1.25e-051891206afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCellSevere-MAIT|World / Disease group and Cell class

CERK GPR65 TTC39C SCART1 TNFAIP3 IL7R

1.28e-0519012067a92e0d6a021be23125495927b8571e25c83204a
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.40e-051931206be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.40e-0519312060c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB2 RYR2 PTK2B LINGO1 PTPRN SGSM2

1.40e-0519312068689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell11.5-Airway-Immune-Hematopoietic,_T_Cells|Airway / Age, Tissue, Lineage and Cell class

GPR65 CCDC88B ATP10A TNFAIP3 PREX1 IL7R

1.40e-0519312067c14bc481ed38378b9e6a85f768a1e526c5997e6
ToppCellControl-MAIT|Control / Disease condition and Cell class

CERK GPR65 TTC39C CHD9 SCART1 IL7R

1.44e-051941206ed99f8bff6766795fc396990604366f49ff58181
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CERK GPR65 TTC39C PTPN4 SCART1 IL7R

1.49e-051951206c7b54b210cc2c8ddaefebfba74381adb2ca698b8
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CERK GPR65 TTC39C PTPN4 SCART1 IL7R

1.49e-051951206e173a713d273b135db4f71bdcaada3b0e55d74f1
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN PTPRT JAG2 CROT PTPN14 MED12L

1.49e-0519512066c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CERK GPR65 TTC39C PTPN4 SCART1 IL7R

1.49e-05195120659164d115a0928cc9b79c7661c7190ad695f9d80
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CERK GPR65 TTC39C PTPN4 SCART1 IL7R

1.49e-051951206a8fd42ff6c2bd80d0e3f20fe3bbf7d113b399df1
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

RAPGEF4 JAG2 MFAP2 RSAD2 GLUL DNM3

1.58e-051971206482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_Tcm|Bac-SEP / Disease, condition lineage and cell class

CFAP251 SPATA6L TTC39C CROT LRRC37A IL7R

1.62e-05198120684a07dea22b7771b34118729607b48c2d75df870
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

CPXM2 ADGRB3 PTCH1 RYR2 NELL1 WDR86

1.62e-0519812060c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell(220)_CD8+_Cytotoxic_T_cell|World / immune cells in Peripheral Blood (logTPM normalization)

CERK GPR65 PTPN4 SCART1 TNFAIP3 IL7R

1.62e-0519812062af389b8ea5767ba56fe64d719afe5be3f9a43ec
ToppCellmild-MAIT|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CERK GPR65 TTC39C PTPN4 TNFAIP3 IL7R

1.72e-0520012061e3ef15ce48b9a19a6ac3e08ea0234a9376e6596
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BTAF1 RSAD2 ANKRD11 EIF3A TNFAIP3 HERC5

1.72e-05200120612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

TTC28 PTCH1 RYR2 NELL1 GPSM2 WDR86

1.72e-052001206a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

ADGRB3 RYR2 NELL1 PTK2B LINGO1 SEC14L5

1.72e-0520012064409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IL12A ADARB2 PTPN14 DNAH17 MED12L

2.53e-051281205076ba9de63b9a4b5a2f7e7924b9a86e8eafce91f
ToppCell3'_v3-blood-Lymphocytic_Invariant-Inducer-like-MAIT|blood / Manually curated celltypes from each tissue

GPR65 SCART1 WDR86 TNFAIP3 IL7R

4.15e-0514212051175d4390d204ffa3a2d2fe24486f85d3b639b72
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

HCN3 GCKR CCDC88B SCART1 TRPV6

4.90e-051471205baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

HCN3 HLCS AXDND1 CYP2R1 IL7R

5.22e-05149120508fb6be5599c5988890c851ce5ac6781c319948e
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

ADCY10 TTC39C RSAD2 IL7R HERC5

5.74e-051521205b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

AXDND1 IFFO2 SCART1 WDR86 IL7R

6.30e-05155120583430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell3'_v3-Lung-Lymphocytic_Invariant-Inducer-like-MAIT|Lung / Manually curated celltypes from each tissue

GPR65 SCART1 WDR86 TNFAIP3 IL7R

6.30e-05155120572c61be0a8d3ee10600a33c58fb01c35fd3f14d4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR RAPGEF4 ADGRB3 IFFO2 PREX1

6.30e-05155120559035d792c26d870a8b097939e97fa47859ba68c
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l26|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CERK GPR65 AVPR2 BLM WDR86

6.50e-051561205da5cfa8fa9595613f04ce9511f8b42bad34d995a
ToppCellVE-CD8-naive_CD4|VE / Condition, Cell_class and T cell subcluster

LCMT2 SPTBN5 IFFO2 DNM3 WDR86

7.32e-051601205255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCellURO-Lymphocyte-T_NK-CD4_CTL|URO / Disease, Lineage and Cell Type

RYR2 PTPN4 HOXB6 PTPRN IL7R

7.77e-0516212051afeeb17e263cf625a4f285203cf82f973735193
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C PTPN4 TNFAIP3 IL7R

7.99e-05163120511cc18f36604d9a5f4e7fb8626a8f0fb141da5e1
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TICRR GPR65 RYR2 LRRC37A IL7R

8.71e-05166120526f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th1|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C RYR2 TNFAIP3 IL7R

8.96e-0516712059c55ec8f70b86d4d3d5c2a6ecd9bff2dafe68c11
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN GPR65 ZNF180 ADGRB2 CCDC88B

8.96e-051671205f5bffa77061baec0ba87bd688a047595f32534db
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IPPK CCDC88B STAT5A CYP2R1 TBCK

9.22e-0516812054c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD51D TTC28 STT3A CCNF SGSM2

9.22e-051681205ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellControl-Lymphocyte-T_NK-MAIT|Control / Disease, Lineage and Cell Type

GPR65 TTC39C PTPN4 TNFAIP3 IL7R

9.48e-0516912058c2aac193a9c500f01a99a2ee530839c851b6222
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SZT2 UBE3B PEX26 PTPRN WDR20

1.00e-041711205d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCellHealthy_donor-MAIT|World / disease group, cell group and cell class (v2)

GPR65 SCART1 WDR86 TNFAIP3 IL7R

1.03e-0417212056524eb2be1c78700ad367e62624a4d7eb48b54f0
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CERK CPXM2 TNFAIP3 GRHL3 TRPV5

1.06e-0417312050f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR GPR65 NUP210 TNFAIP3 IL7R

1.09e-041741205ecee7e012ccd7876fb9df8aa939f8eb05b0c2b13
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR GPR65 NUP210 TNFAIP3 IL7R

1.09e-041741205693fc31bed0f560644e419fa70ef09f863425416
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ATP10A SCART1 TNFAIP3 PREX1 IL7R

1.09e-0417412055e6050d20a5b27640f6a200441125b8ceba123c8
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like|blood / Manually curated celltypes from each tissue

GPR65 TTC39C SCART1 TNFAIP3 IL7R

1.09e-04174120551be6f29308c01593978cbee92114151a5916c9c
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Megakaryocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GCKR LGALSL MED12L DNM3 SEC14L5

1.12e-041751205b85279b9efd72d7074c4226d50ce139a38c0e1c1
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT|lymph-node_spleen / Manually curated celltypes from each tissue

GPR65 TTC39C SCART1 WDR86 IL7R

1.15e-04176120525c197d3b39deffa4801a1d12cdb54320cbae509
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A SPTBN5 IL7R

1.15e-041761205ed7ba2a3af3b060dec98b60f09f96000a67f7e63
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRT CFAP54 PTPN14 DNAH17 DNM3

1.15e-041761205327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A SPTBN5 IL7R

1.15e-041761205e788c7e0b2bfde31fddbf9e04d07140f8b964857
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPXM2 GREB1L NELL1 CROT PTPN14

1.18e-04177120596d639407f79669f3990138793d157b94273581c
ToppCell(9)_Platelet|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RYR2 PTPRN LGALSL DNM3 SEC14L5

1.18e-0417712050830944c43de300815831a9e2b2fce40965e7d12
ToppCell(9)_Platelet|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RYR2 PTPRN LGALSL DNM3 SEC14L5

1.18e-041771205e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic-T_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51C RAPSN PTPN4 TNFAIP3 IL7R

1.18e-041771205baf78a8dad55f124f56585f88b10b58c0269680f
ToppCellCOPD-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

CPXM2 OAT ADARB2 TINAGL1 JAG2

1.21e-041781205441d1dba720141891b11f404744c59834d80e6c5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A PLEKHG4B IL7R

1.24e-041791205820289f14ecf165758529c236bb220bb1a744f02
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERCC4 STK32B ATP10A PLEKHG4B IL7R

1.24e-041791205e5f781d35449628a7f356d71e26231dd63482eec
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 STAT5A SCART1 TNFAIP3 IL7R

1.24e-041791205b8bc03f60a7ac76ea6ee90d0512f0dc1d1d2a087
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th17|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 TTC39C SCART1 TNFAIP3 IL7R

1.24e-04179120561472d75f4a3c4374eeb55ef79982ae4054dadaa
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADARB2 PLEKHG4B PTPN14 DNAH17 MED12L

1.24e-04179120555bc69f107fc710db7617c428575792adfdbbcc1
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TTC39C PTPN4 WDR86 TNFAIP3 IL7R

1.24e-041791205b0585a8e596c3d8e434af943e65207fa5877600d
ComputationalGenes in the cancer module 318.

RAD51C RAD51D WRN BLM

4.84e-0528794MODULE_318
DiseaseBasal cell carcinoma

ERCC4 PTCH1 STAT5B

1.03e-05111193C0007117
Disease1-myristoyl-2-arachidonoyl-GPC (14:0/20:4) measurement

RAPSN GCKR GREB1L

1.37e-05121193EFO_0800453
Diseaselevel of Phosphatidylcholine (16:1_18:1) in blood serum

RAPSN GCKR GREB1L

1.78e-05131193OBA_2045082
Diseaseneutrophil count

IPPK SCFD2 DNAJC13 SPATA6L RAPSN IPO7 TTC28 TTC39C CHD9 GCKR JAG2 PTPN14 LINGO1 ANKRD11 DNM3 TNFAIP3 PREX1

4.03e-05138211917EFO_0004833
DiseaseHereditary breast ovarian cancer syndrome

RAD51C RAD51D

9.63e-0541192cv:C0677776
DiseaseAcute monocytic leukemia

RAD51C ERCC4 BLM

1.55e-04261193C0023465
Diseasehereditary breast ovarian cancer syndrome (is_implicated_in)

RAD51C RAD51D

1.60e-0451192DOID:5683 (is_implicated_in)
Disease1-myristoyl-2-docosahexaenoyl-GPC (14:0/22:6) measurement

GCKR GREB1L

1.60e-0451192EFO_0800454
Disease1-myristoyl-2-linoleoyl-GPC (14:0/18:2) measurement

RAPSN GCKR

1.60e-0451192EFO_0800452
DiseaseWerner syndrome (implicated_via_orthology)

WRN BLM

1.60e-0451192DOID:5688 (implicated_via_orthology)
DiseaseMalignant tumor of breast

RAD51C RAD51D RB1CC1

1.74e-04271193cv:C0006142
DiseaseBreast neoplasm

RAD51C RAD51D RB1CC1

1.74e-04271193cv:C1458155
DiseaseFamilial cancer of breast

RAD51C RAD51D RB1CC1

1.74e-04271193cv:C0346153
DiseaseMiller Dieker syndrome

RAD51C ERCC4 BLM

2.16e-04291193C0265219
Diseasetriacylglycerol 56:7 measurement

RAPSN GCKR PTPRT

2.16e-04291193EFO_0010434
Disease2-myristoyl-GPC (14:0) measurement

GCKR GREB1L

2.39e-0461192EFO_0800242
Disease1-myristoyl-GPC (14:0) measurement

GCKR GREB1L

2.39e-0461192EFO_0800221
Diseasegondoic acid measurement

RAPSN GCKR

2.39e-0461192EFO_0007975
Diseaseplatelet measurement

CFAP251 RAPSN CHD9 GCKR MED12L DNM3 SEC14L5

2.98e-043151197EFO_0005036
Diseaseneuropilin-1 measurement

GCKR NELL1

3.34e-0471192EFO_0020603
Diseasemyeloid white cell count

IPPK SCFD2 DNAJC13 RAPSN TTC28 GCKR JAG2 PTK2B MED12L TNFAIP3 PREX1 IL7R

4.14e-0493711912EFO_0007988
DiseaseCrohn's disease

RAPSN GPR65 GCKR CCDC88B STAT5B NELL1 PTK2B LGALSL

4.32e-044411198EFO_0000384
Disease1-stearoyl-2-docosapentaenoyl-GPC (18:0/22:5n3) measurement

RAPSN GCKR

4.44e-0481192EFO_0800455
Diseasephosphatidylcholine 32:1 measurement

RAPSN GCKR NELL1

4.87e-04381193EFO_0010373
Diseasebody weight

IPPK RAPSN ADGRB3 RABGAP1 GCKR PTCH1 PTPRT NELL1 PTPN14 LINGO1 PTPRN DNM3 DLEU7 EIF2AK3

5.69e-04126111914EFO_0004338
Diseaseplatelet-to-lymphocyte ratio

CFAP251 RAPSN TTC28 PTPN4 MED12L DNM3 IL7R

6.94e-043631197EFO_0008446
Diseasetriacylglycerol 56:6 measurement

RAPSN GCKR PTPRT

7.02e-04431193EFO_0010433
Diseasecreatinine measurement

DNAJC13 RAPSN OBSCN CHD9 BTAF1 GCKR ADARB2 TINAGL1 JAG2 NELL1 PTPN14 ANKRD11

7.03e-0499511912EFO_0004518
Disease1-palmitoyl-2-oleoyl-GPE (16:0/18:1) measurement

RAPSN GCKR

7.11e-04101192EFO_0800608
Diseaseoleoyl-arachidonoyl-glycerol (18:1/20:4) [1] measurement

RAPSN GCKR

7.11e-04101192EFO_0800507
Disease1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1) measurement

RAPSN GCKR

7.11e-04101192EFO_0800464
Diseaselevel of Sterol ester (27:1/18:3) in blood serum

RAPSN GCKR

7.11e-04101192OBA_2045193
Diseaselinguistic error measurement, specific language impairment

HLCS RTL1

7.11e-04101192EFO_0007798, EFO_1001510
Diseaselevel of phosphatidylcholine

RAPSN GCKR

7.11e-04101192OBA_2040179
Diseasecoffee consumption measurement, tea consumption measurement

GCKR LINGO1 SCART1

7.51e-04441193EFO_0006781, EFO_0010091
Diseaseornithine measurement

OAT TINAGL1 NELL1

7.51e-04441193EFO_0009776
DiseaseMultiple Sclerosis

IL12A TNFAIP3 IL7R

8.02e-04451193C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

IL12A TNFAIP3 IL7R

8.02e-04451193C0751324
Disease1-stearoyl-2-oleoyl-GPE (18:0/18:1) measurement

RAPSN GCKR

8.66e-04111192EFO_0800269
DiseaseCognitive impairment

PTPRT RYR2

8.66e-04111192HP_0100543
Diseasehippocampal CA1 volume

SCFD2 RABGAP1 PTCH1

9.69e-04481193EFO_0009394
Diseasepeptide measurement

RAPGEF4 PTPRT NELL1 GLUL

1.01e-031091194EFO_0010520
Diseasephosphatidylcholine 34:4 measurement

RAPSN GCKR

1.04e-03121192EFO_0010378
Diseasetriacylglycerol 53:2 measurement

RAPSN GCKR

1.04e-03121192EFO_0021484
Diseasecholesteryl ester 24:5 measurement

RAPSN AXDND1

1.04e-03121192EFO_0021448
Diseaselevel of Phosphatidylcholine (16:0_20:2) in blood serum

RAPSN GCKR

1.04e-03121192OBA_2045074
Diseaseobsolete_red blood cell distribution width

ATG101 CFAP251 DNAJC13 RAPSN TTC28 UBE3B HCN3 LRRC37A2 SMG5 GCKR ZBTB24 CCNF WDR20 NUP210

1.08e-03134711914EFO_0005192
Diseasebody surface area

TICRR GCKR PTCH1 ZBTB24 LGALSL ANKRD11 DNM3 DLEU7 EIF2AK3

1.21e-036431199EFO_0022196
Diseasecancer

TTC28 ANKRD11 TRPV6 TNFAIP3 PREX1 TRPV5 SEC14L5

1.22e-034001197MONDO_0004992
DiseaseSjogren's Syndrome

IL12A TNFAIP3

1.22e-03131192C1527336
DiseaseSicca Syndrome

IL12A TNFAIP3

1.22e-03131192C0086981
Diseaselevel of Phosphatidylcholine (16:0_18:3) in blood serum

RAPSN GCKR

1.22e-03131192OBA_2045072
Diseaselymphocyte measurement

TTC28 STT3A NUP210 IL7R

1.31e-031171194EFO_0803546
Diseaseforced expiratory volume

PTCH1 ZBTB24 RYR2 MFAP2 HOXB6 DNM3 DLEU7 EIF2AK3 PREX1 HERC5

1.37e-0378911910EFO_0004314
DiseaseMetabolic Bone Disorder

CYP2R1 ANKRD11

1.42e-03141192C0005944
Diseaselevel of Phosphatidylethanolamine (18:2_0:0) in blood serum

RAPSN GCKR

1.42e-03141192OBA_2045143
DiseaseHereditary Breast and Ovarian Cancer Syndrome

RAD51C RAD51D

1.42e-03141192C0677776
DiseaseOsteopenia

CYP2R1 ANKRD11

1.64e-03151192C0029453
Diseaselevel of Triacylglycerol (53:3) in blood serum

RAPSN GCKR

1.64e-03151192OBA_2045165
Diseaseirritable bowel syndrome symptom measurement

SCFD2 ZBTB14 NELL1

1.68e-03581193EFO_0021536
Diseasephosphatidylcholine 32:2 measurement

RAPSN GCKR

1.87e-03161192EFO_0010374
DiseaseTinnitus

MON2 RB1CC1 ATP10A JAG2

1.93e-031301194HP_0000360
Diseasepsoriasis vulgaris

CCDC88B TNFAIP3 GRHL3

1.94e-03611193EFO_1001494
Diseaseprimary biliary cirrhosis

IL12A CCDC88B DLEU7 IL7R

2.10e-031331194EFO_1001486
Diseaselevel of Phosphatidylcholine (14:0_18:2) in blood serum

RAPSN GCKR

2.11e-03171192OBA_2045063
DiseaseMYELODYSPLASTIC SYNDROME

RAD51C ERCC4 BLM

2.54e-03671193C3463824
Diseaseexercise test

WRN RYR2

2.92e-03201192EFO_0004328
Diseasesaturated fatty acids to total fatty acids percentage

RAPSN GCKR

3.22e-03211192EFO_0022305
Diseaselevel of Phosphatidylcholine (16:1_18:2) in blood serum

RAPSN GCKR

3.22e-03211192OBA_2045083
Diseasebreast cancer (is_implicated_in)

WRN RB1CC1 PTK2B TNFAIP3

3.24e-031501194DOID:1612 (is_implicated_in)
Diseasetriacylglycerol 54:6 measurement

RAPSN GCKR

3.53e-03221192EFO_0010424
Diseasephosphatidylcholine 34:3 measurement

RAPSN GCKR

3.53e-03221192EFO_0010377
DiseaseGranulomatous Slack Skin

STAT5B TNFAIP3

3.53e-03221192C0376407
DiseaseS-6-hydroxywarfarin measurement

SPATA6L CHD9 OAT BTAF1 THOC5 LINGO1

3.85e-033681196EFO_0803326
DiseaseBMI-adjusted fasting blood glucose measurement

RAPSN GCKR

3.86e-03231192EFO_0008036
DiseaseLymphoma, T-Cell, Cutaneous

STAT5B TNFAIP3

3.86e-03231192C0079773
Diseaseinsulin sensitivity measurement

RAPSN GCKR

3.86e-03231192EFO_0004471
Diseaselevel of Phosphatidylinositol (18:0_20:4) in blood serum

RAPSN GCKR

3.86e-03231192OBA_2045158
Diseasearginine measurement

TINAGL1 HPS1

3.86e-03231192EFO_0020990

Protein segments in the cluster

PeptideGeneStartEntry
FVITAVHCFLRREVQ

ADGRB2

1196

O60241
VHCFLRREVQDVVKC

ADGRB2

1201

O60241
RCRLALVTAFVAQIH

CFAP54

2386

Q96N23
LIVSCEQEILRVHCR

ANKRD11

2526

Q6UB99
EQEILRVHCRAARTI

ANKRD11

2531

Q6UB99
ASVQCEHRELFIRHI

CCDC88B

146

A6NC98
IEERERSVCLHIFLQ

EIF2AK3

906

Q9NZJ5
VHCILRREVQDAFRC

ADGRB3

1146

O60242
EVIQKECAHIRASFR

AP1G2

26

O75843
LENEVIECHRIRFCN

ADCY10

916

Q96PN6
KEIHVGDFVRLRCNE

ATP10A

161

O60312
IREERQRVLLYVCAH

CFAP251

266

Q8TBY9
VCQEYLARNARIVHL

CPXM2

396

Q8N436
VDRVVDLATACIQHL

RAD51C

166

O43502
AEALRRIQVVHAFDI

RAD51D

161

O75771
LLSRHVVCQVDFIIR

OR4N4C

301

A0A096LPK9
LQRELRAHVVRFHEC

RAPSN

341

Q13702
LVVNDCHAEVVARRA

ADARB2

426

Q9NS39
LVVAHAQRCVVLRFL

IPPK

21

Q9H8X2
ARDRQHTEVVCNILL

PTPN4

21

P29074
VQLERCRVVAQDSHF

RB1CC1

796

Q8TDY2
ELFRIHVFRCEIQEA

RABGAP1

241

Q9Y3P9
HVFRCEIQEAVSRIL

RABGAP1

246

Q9Y3P9
VLRCDAIVDLIHDIQ

NUP210

106

Q8TEM1
FAIARRLAQDRAHVV

DHRS4L2

46

Q6PKH6
LVALAVALCVRQHAR

PTPRN

591

Q16849
VEILCEHPRFRVFVD

LGALSL

126

Q3ZCW2
AIVCCQRHLDISREL

GPSM2

121

P81274
HLVDEEFFQRVRALC

MAP1S

961

Q66K74
LIARQCFSLEDVVQH

MED12L

1091

Q86YW9
LIVICCHRRSLQEDE

LRRC37A2

1601

A6NM11
LIVICCHRRSLQEDE

LRRC37A

1601

A6NMS7
VEFRNICSHLALQIE

DLEU7

156

Q6UYE1
VRVLATAHRQLQDIC

GPBAR1

186

Q8TDU6
HVAHLELQIRVRCDE

JAG2

186

Q9Y219
VVVCEADTGRIHRFV

GMPPB

146

Q9Y5P6
LGRFHEVRSVLADCV

HLCS

176

P50747
RLCEETERIVANHIR

DNM3

451

Q9UQ16
EDRHCIRENIVEAII

IPO7

86

O95373
LLSRHVVCQVDFIIR

OR4N4

301

Q8N0Y3
RRCTEIVAIDALHFR

PARG

816

Q86W56
VVHLDFRAALETCER

PEX26

46

Q7Z412
QDRAVLCHRKRFVAV

LINGO1

51

Q96FE5
CQIHRVDDIQARDEV

IL7R

306

P16871
CILLHAFRIRAVTID

IL12A

196

P29459
IDRCVEAFVEVGRLH

GCAT

401

O75600
LRAVAVESIHRFCVQ

MON2

351

Q7Z3U7
REEIINFTCRGLVAH

HCN3

411

Q9P1Z3
HGLADRVINCREVLE

GREB1L

801

Q9C091
LLLHVDCNRIYERVI

NELL1

161

Q92832
ADIDEDIIHRIFRIC

PTPRT

1306

O14522
CLLEILRTFERAHQV

GCKR

291

Q14397
RIEIAHALCLTERQI

HOXB6

176

P17509
ELLHRLNFFVEVCRR

HERC5

596

Q9UII4
HFICIRFEALTEARQ

OBSCN

5056

Q5VST9
VHVVALATEQERQIC

ATG101

126

Q9BSB4
HDVEVLERNFQTILC

ASPHD2

186

Q6ICH7
IIHARALVRECLAET

CDK2AP2

106

O75956
RQLNEHDVEIICRAL

CHD9

1521

Q3L8U1
ERLVHRAVCQIKIFC

GRHL3

386

Q8TE85
RKLLARFVIDEAHCV

BLM

786

P54132
VLQLRVHTFAACAVV

BTAF1

851

O14981
AVVHESLRAECQLQR

CCNF

166

P41002
FEDAVAHICRINRIL

DNAH17

2776

Q9UFH2
IVDAARHCDLQVRID

EIF3A

471

Q14152
IEVRVHCQLVRLFAR

CERK

511

Q8TCT0
HCQLVRLFARGIEEN

CERK

516

Q8TCT0
TEAVLHEVLRFCNIV

CYP2R1

361

Q6VVX0
FHELIRQVSVDCADR

AXDND1

266

Q5T1B0
RVIHALSENELCVRA

DNAJC13

2071

O75165
NVRFRCFLAKVHELE

IFFO2

61

Q5TF58
ESINCVHRDIAVRNI

PTK2B

541

Q14289
ELCIEALERHVIQAV

HPS1

181

Q92902
AVHVVERSCRLRVDA

SEC14L5

51

O43304
CQVRHRIEAIVAFSD

RYR2

1916

Q92736
ICVRTVCAHEELLRA

MFAP2

136

P55001
HIVVLCRGRAFVFDV

CROT

191

Q9UKG9
RLACADIRVHQAVLY

OR10Q1

191

Q8NGQ4
ARFILHRVCEDFGVI

GLUL

221

P15104
REFHEFIVLCQLTLQ

RTL1

211

A6NKG5
EAERHVLRLQFFVVL

SZT2

3181

Q5T011
IVLREDNCHFLRVDK

RAPGEF4

436

Q8WZA2
IRECVFLHRNRFLEE

SPATA6L

131

Q8N4H0
HFRIVRGVNECDIES

TINAGL1

436

Q9GZM7
HQACIDENLEVVRFL

PPP1R12C

106

Q9BZL4
AVVEAVHRLDLILCN

SMG5

26

Q9UPR3
FERFLERHKEVSCLV

RSAD2

276

Q8WXG1
VREQLFHERIRECII

LMBR1L

11

Q6UX01
CLEAVAQRLELRETH

PTPN14

46

Q15678
LRRDAIFCQALVAAV

PREX1

1321

Q8TCU6
FHVRCERRDSKVEVI

PTCH1

1416

Q13635
KACEVVVRQREREAH

SGSM2

611

O43147
FHITIDIRNVCVFLA

STT3A

106

P46977
RQHEVCCQDVVVKLR

SHPRH

936

Q149N8
TQQILEVHLVRFCVR

SPATA31E1

831

Q6ZUB1
VRCIRHILYNEQRLV

STAT5B

106

P51692
IHHRFVRDEIQCVIA

WRN

806

Q14191
IAHERLTVLIFLEDC

WDR20

531

Q8TBZ3
VEILRDIICRSHFQY

SCFD2

86

Q8WU76
ELCTRHQVLFIADEI

OAT

251

P04181
AEVHRHQAVCVDLVR

SPTBN5

686

Q9NRC6
VRCIRHILYNEQRLV

STAT5A

106

P42229
VVREVCRSHVRIAEA

CHST6

241

Q9GZX3
IAVFLCIHIVLRFRN

VPS52

441

Q8N1B4
VVEDVKFRAHRCVLA

ZBTB14

41

O43829
VCRTKEAEFQRHVLQ

TICRR

421

Q7Z2Z1
LEEIHIFVLCNILRR

TNFAIP3

191

P21580
ELRAAEVVVCFQLRH

PLEKHG4B

966

Q96PX9
ACVNSEEIVRLLIEH

TRPV6

211

Q9H1D0
RNVNGVDRLCVLHVE

SCART1

151

Q4G0T1
RLVVVAEHCERSLED

TBCK

66

Q8TEA7
LLIRCILEHAVNFED

GPR65

246

Q8IYL9
HELVTRALQLVQFDC

PIAS4

36

Q8N2W9
HCLRSVDNLFVVVQE

THUMPD3

86

Q9BV44
LCDITLIVENVHFRA

ZBTB24

36

O43167
VAFTQRKAVIHERVC

ZNF180

176

Q9UJW8
RAAVVIQAHVRSFLC

UBE3B

31

Q7Z3V4
ALVCFEKRLVVAHEL

TTC28

936

Q96AY4
LQHCLETVREEFIIF

STK32B

351

Q9NY57
ILVYRAHRIIESCQE

ERCC4

131

Q92889
AHRIIESCQEAFILR

ERCC4

136

Q92889
RAVRHCVRAFLEQIG

LCMT2

61

O60294
ALELAVDQREIQHVC

TTC39C

341

Q8N584
AIEIEERRIQSCVHF

THOC5

81

Q13769
EQLRVFREHRGSVIC

WDR86

226

Q86TI4
IAACQVLIFREIHAS

AVPR2

221

P30518
ACVNSEEIVRLLIEH

TRPV5

171

Q9NQA5