Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpantothenate kinase activity

PANK3 PANK1 PANK2

8.86e-0741223GO:0004594
GeneOntologyMolecularFunctionATP-dependent activity

MYH7 KIF6 WAPL MYO1D MYO1E MYO5A MYO5B MCM3 MCM4 MCM5 CHD2 CHD5 CHD6 DNAH6 FIGNL1 PIF1

1.06e-0661412216GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

CPLANE2 NUGGC MYH7 KIF6 RAB17 MYO1E MYO5B MCM3 MCM4 MCM5 CHD2 RHOU CHD5 CHD6 DNAH6 FIGNL1 PIF1 ADSS1

1.11e-0677512218GO:0017111
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

WAPL MCM3 MCM4 MCM5 CHD2 CHD5 CHD6 PIF1

1.13e-061271228GO:0008094
GeneOntologyMolecularFunctionATP hydrolysis activity

MYH7 KIF6 MYO1E MYO5B MCM3 MCM4 MCM5 CHD2 CHD5 CHD6 DNAH6 FIGNL1 PIF1

3.09e-0644112213GO:0016887
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH7 MYO1D MYO1E MYO5A MYO5B

3.35e-06381225GO:0000146
GeneOntologyMolecularFunctionpyrophosphatase activity

CPLANE2 NUGGC MYH7 KIF6 RAB17 MYO1E MYO5B MCM3 MCM4 MCM5 CHD2 RHOU CHD5 CHD6 DNAH6 FIGNL1 PIF1 ADSS1

3.41e-0683912218GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

CPLANE2 NUGGC MYH7 KIF6 RAB17 MYO1E MYO5B MCM3 MCM4 MCM5 CHD2 RHOU CHD5 CHD6 DNAH6 FIGNL1 PIF1 ADSS1

3.46e-0684012218GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

CPLANE2 NUGGC MYH7 KIF6 RAB17 MYO1E MYO5B MCM3 MCM4 MCM5 CHD2 RHOU CHD5 CHD6 DNAH6 FIGNL1 PIF1 ADSS1

3.46e-0684012218GO:0016818
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH7 KIF6 MYO1D MYO1E MYO5A MYO5B DNAH6

8.04e-061181227GO:0003774
GeneOntologyMolecularFunctionsingle-stranded DNA helicase activity

MCM3 MCM4 MCM5 PIF1

1.07e-05231224GO:0017116
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

MTMR1 MTMR14 SYNJ1

3.54e-05111223GO:0052629
GeneOntologyMolecularFunctionhelicase activity

MCM3 MCM4 MCM5 CHD2 CHD5 CHD6 PIF1

5.32e-051581227GO:0004386
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate phosphatase activity

MTMR1 MTMR14 SYNJ1

7.71e-05141223GO:0004438
GeneOntologyMolecularFunctionphosphatidylinositol monophosphate phosphatase activity

MTMR1 MTMR14 SYNJ1

9.60e-05151223GO:0052744
GeneOntologyMolecularFunctionTFIIH-class transcription factor complex binding

HNRNPU GTF2E2

1.11e-0431222GO:0001097
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR1 MTMR14 SYNJ1

1.18e-04161223GO:0106018
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

WAPL MCM3 MCM4 MCM5 CHD2 CHD5 CHD6 PIF1

2.10e-042621228GO:0140097
GeneOntologyMolecularFunctionacetyl-CoA binding

PANK3 PANK1

2.20e-0441222GO:1905502
GeneOntologyMolecularFunctionDNA helicase activity

MCM3 MCM4 MCM5 PIF1

5.63e-04621224GO:0003678
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

MTMR1 MTMR14 SYNJ1

5.85e-04271223GO:0034593
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

MTMR1 MTMR14 SYNJ1

8.01e-04301223GO:0052866
GeneOntologyMolecularFunctionglutamate-gated calcium ion channel activity

GRIN2C GRIN2D

1.01e-0381222GO:0022849
GeneOntologyMolecularFunctionNMDA glutamate receptor activity

GRIN2C GRIN2D

1.01e-0381222GO:0004972
GeneOntologyMolecularFunctioncytoskeletal protein binding

DLG5 MYH7 KIF6 MYO1D MYO1E MYO5A MYO5B STRBP CAPN1 SYNPO2L HNRNPU NEFM IFT88 SSH2 USH2A ADSS1

1.07e-03109912216GO:0008092
GeneOntologyMolecularFunctiondouble-stranded RNA binding

STRBP HNRNPU NLRP6 DGCR8

1.34e-03781224GO:0003725
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD2 CHD5 CHD6

1.49e-03371223GO:0140658
GeneOntologyMolecularFunctionactin binding

MYH7 MYO1D MYO1E MYO5A MYO5B SYNPO2L HNRNPU SSH2 ADSS1

2.72e-034791229GO:0003779
GeneOntologyMolecularFunctionactin filament binding

MYH7 MYO1D MYO1E MYO5A MYO5B ADSS1

2.73e-032271226GO:0051015
GeneOntologyBiologicalProcesspremeiotic DNA replication

MCM3 MCM4 MCM5

3.89e-0661213GO:0006279
GeneOntologyBiologicalProcessnuclear DNA replication

NUGGC DONSON MCM3 MCM4 MCM5

7.23e-06461215GO:0033260
GeneOntologyBiologicalProcesscell cycle DNA replication

NUGGC DONSON MCM3 MCM4 MCM5

1.21e-05511215GO:0044786
GeneOntologyBiologicalProcesscoenzyme A biosynthetic process

PANK3 PANK1 PANK2

4.17e-05121213GO:0015937
GeneOntologyBiologicalProcessdouble-strand break repair via break-induced replication

MCM3 MCM4 MCM5

4.17e-05121213GO:0000727
GeneOntologyBiologicalProcessregulation of DNA-templated DNA replication initiation

MCM3 MCM4 MCM5

8.51e-05151213GO:0030174
GeneOntologyCellularComponentmyosin complex

MYH7 MYO1D MYO1E MYO5A MYO5B

2.43e-05591225GO:0016459
GeneOntologyCellularComponentMCM complex

MCM3 MCM4 MCM5

3.09e-05111223GO:0042555
GeneOntologyCellularComponentCMG complex

MCM3 MCM4 MCM5

3.09e-05111223GO:0071162
GeneOntologyCellularComponentDNA replication preinitiation complex

MCM3 MCM4 MCM5

5.31e-05131223GO:0031261
GeneOntologyCellularComponentpostsynaptic cytoskeleton

MYO5A MYO5B NEFM

4.57e-04261223GO:0099571
DomainP-loop_NTPase

CPLANE2 NUGGC DLG5 MYH7 KIF6 RAB17 MYO1D MYO1E MYO5A MYO5B MCM3 MCM4 MCM5 CHD2 RHOU HNRNPU NLRP6 CHD5 CHD6 DNAH6 FIGNL1 PIF1 ADSS1

4.67e-0984812123IPR027417
DomainType_II_PanK

PANK3 PANK1 PANK2

1.06e-0641213IPR004567
DomainFumble

PANK3 PANK1 PANK2

1.06e-0641213PF03630
DomainMyosin_head_motor_dom

MYH7 MYO1D MYO1E MYO5A MYO5B

4.44e-06381215IPR001609
DomainMYOSIN_MOTOR

MYH7 MYO1D MYO1E MYO5A MYO5B

4.44e-06381215PS51456
DomainMyosin_head

MYH7 MYO1D MYO1E MYO5A MYO5B

4.44e-06381215PF00063
DomainMYSc

MYH7 MYO1D MYO1E MYO5A MYO5B

4.44e-06381215SM00242
DomainMCM_N

MCM3 MCM4 MCM5

5.23e-0661213PF14551
DomainMCM_CS

MCM3 MCM4 MCM5

5.23e-0661213IPR018525
DomainMCM_N

MCM3 MCM4 MCM5

5.23e-0661213IPR027925
DomainMCM_OB

MCM3 MCM4 MCM5

1.45e-0581213PF17207
DomainMCM_OB

MCM3 MCM4 MCM5

1.45e-0581213IPR033762
DomainMCM_2

MCM3 MCM4 MCM5

1.45e-0581213PS50051
DomainMCM_1

MCM3 MCM4 MCM5

1.45e-0581213PS00847
DomainMCM

MCM3 MCM4 MCM5

2.17e-0591213SM00350
DomainMCM_dom

MCM3 MCM4 MCM5

2.17e-0591213IPR001208
DomainMCM

MCM3 MCM4 MCM5

2.17e-0591213IPR031327
DomainMCM

MCM3 MCM4 MCM5

2.17e-0591213PF00493
Domain-

CPLANE2 NUGGC DLG5 RAB17 MYO1E MCM3 MCM4 MCM5 CHD2 RHOU HNRNPU CHD5 CHD6 DNAH6 FIGNL1 PIF1

2.56e-05746121163.40.50.300
DomainIQ_motif_EF-hand-BS

MYH7 MYO1D MYO1E MYO5A MYO5B

2.98e-04901215IPR000048
DomainIQ

MYH7 MYO1D MYO1E MYO5A MYO5B

3.46e-04931215PS50096
DomainGRAM

WBP2 OXR1 MTMR1

3.73e-04221213PF02893
DomainAA-permease/SLC12A_dom

SLC7A7 SLC7A11 SLC12A3

3.73e-04221213IPR004841
DomainAA_permease

SLC7A7 SLC7A11 SLC12A3

3.73e-04221213PF00324
DomainGRAM

WBP2 OXR1 MTMR1

3.73e-04221213IPR004182
DomainMyosin_S1_N

MYO5A MYO5B

4.11e-0451212IPR008989
DomainPAN_AP

HGF PLG

4.11e-0451212SM00473
DomainChromo_domain

CHD2 CHD5 CHD6

4.86e-04241213IPR023780
DomainDilute_dom

MYO5A MYO5B

6.14e-0461212IPR002710
DomainRBD

RAF1 BRAF

6.14e-0461212PF02196
DomainDIL

MYO5A MYO5B

6.14e-0461212PF01843
DomainDILUTE

MYO5A MYO5B

6.14e-0461212PS51126
DomainDIL

MYO5A MYO5B

6.14e-0461212SM01132
DomainChromo

CHD2 CHD5 CHD6

6.18e-04261213PF00385
DomainCHROMO_1

CHD2 CHD5 CHD6

7.72e-04281213PS00598
DomainCHROMO_2

CHD2 CHD5 CHD6

7.72e-04281213PS50013
DomainPan_app

HGF PLG

8.56e-0471212IPR003609
DomainPAN

HGF PLG

8.56e-0471212PS50948
DomainRBD

RAF1 BRAF

8.56e-0471212SM00455
DomainMyosin_TH1

MYO1D MYO1E

8.56e-0471212PF06017
DomainMyosin_TH1

MYO1D MYO1E

8.56e-0471212IPR010926
DomainPAN_1

HGF PLG

8.56e-0471212PF00024
DomainRBD_dom

RAF1 BRAF

8.56e-0471212IPR003116
DomainRBD

RAF1 BRAF

8.56e-0471212PS50898
DomainTH1

MYO1D MYO1E

8.56e-0471212PS51757
DomainSNF2_N

CHD2 CHD5 CHD6

1.15e-03321213IPR000330
DomainSNF2_N

CHD2 CHD5 CHD6

1.15e-03321213PF00176
DomainChromodomain-like

CHD2 CHD5 CHD6

1.15e-03321213IPR016197
DomainIQ

MYO1D MYO1E MYO5A MYO5B

1.17e-03711214PF00612
DomainChromo/shadow_dom

CHD2 CHD5 CHD6

1.26e-03331213IPR000953
DomainCHROMO

CHD2 CHD5 CHD6

1.26e-03331213SM00298
DomainTyr_Pase_AS

MTMR1 PTPRB MTMR14 SSH2

1.29e-03731214IPR016130
DomainDNA/RNA_helicase_DEAH_CS

CHD2 CHD5 CHD6

1.49e-03351213IPR002464
DomainDEAH_ATP_HELICASE

CHD2 CHD5 CHD6

1.90e-03381213PS00690
DomainIQ

MYH7 MYO1D MYO5A MYO5B

1.90e-03811214SM00015
DomainFYVE_2

SYTL4 SYTL5

2.20e-03111212PF02318
DomainRABBD

SYTL4 SYTL5

2.63e-03121212PS50916
DomainRab_BD

SYTL4 SYTL5

2.63e-03121212IPR010911
Domain-

MTMR1 PTPRB MTMR14 SSH2

3.02e-039212143.90.190.10
DomainAA_permease_2

SLC7A7 SLC7A11

3.10e-03131212PF13520
DomainAA/rel_permease1

SLC7A7 SLC7A11

3.10e-03131212IPR002293
DomainProt-tyrosine_phosphatase-like

MTMR1 PTPRB MTMR14 SSH2

3.93e-03991214IPR029021
DomainKringle_CS

HGF PLG

5.31e-03171212IPR018056
DomainKRINGLE_1

HGF PLG

5.31e-03171212PS00021
DomainKR

HGF PLG

5.31e-03171212SM00130
DomainKringle

HGF PLG

5.31e-03171212IPR000001
DomainKRINGLE_2

HGF PLG

5.31e-03171212PS50070
DomainKringle

HGF PLG

5.31e-03171212PF00051
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

5.95e-03181212PF10613
DomainGlu/Gly-bd

GRIN2C GRIN2D

5.95e-03181212IPR019594
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

5.95e-03181212SM00918
DomainIontro_rcpt

GRIN2C GRIN2D

5.95e-03181212IPR001320
DomainIono_rcpt_met

GRIN2C GRIN2D

5.95e-03181212IPR001508
DomainLig_chan

GRIN2C GRIN2D

5.95e-03181212PF00060
DomainPBPe

GRIN2C GRIN2D

5.95e-03181212SM00079
PathwayKEGG_MEDICUS_REFERENCE_BREAK_INDUCED_REPLICATION

MCM3 MCM4 MCM5 PIF1

1.07e-078904M47840
PathwayKEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS

DPYD PANK3 PANK1 PANK2

2.67e-0616904M7528
PathwayKEGG_MEDICUS_REFERENCE_DNA_REPLICATION_TERMINATION

MCM3 MCM4 MCM5 PIF1

8.56e-0621904M47861
PathwayREACTOME_COENZYME_A_BIOSYNTHESIS

PANK3 PANK1 PANK2

8.65e-067903M27087
PathwayREACTOME_COENZYME_A_BIOSYNTHESIS

PANK3 PANK1 PANK2

8.65e-067903MM14765
PathwayREACTOME_UNWINDING_OF_DNA

MCM3 MCM4 MCM5

5.31e-0512903M3656
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

RAF1 HGF BRAF

1.08e-0415903M47473
PathwayREACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM

PANK3 PANK1 PANK2

1.08e-0415903MM14782
PathwayKEGG_MEDICUS_REFERENCE_TRAIP_DEPENDENT_REPLISOME_DISASSEMBLY

MCM3 MCM4 MCM5

1.33e-0416903M47862
PathwayBIOCARTA_MCM_PATHWAY

MCM3 MCM4 MCM5

1.92e-0418903M6682
PathwayREACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM

PANK3 PANK1 PANK2

2.65e-0420903M538
PathwayKEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

3.98e-045902M47667
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2C GRIN2D

3.98e-045902MM15655
PathwayREACTOME_BASIGIN_INTERACTIONS

ITGA6 SLC7A7 SLC7A11

4.62e-0424903MM17215
PathwayKEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING

MCM3 MCM4 MCM5

4.62e-0424903M47857
PathwayREACTOME_BASIGIN_INTERACTIONS

ITGA6 SLC7A7 SLC7A11

5.23e-0425903M4974
PathwayWP_PILOCYTIC_ASTROCYTOMA

RAF1 BRAF

5.95e-046902M39584
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

RAF1 BRAF

5.95e-046902M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

RAF1 BRAF

5.95e-046902MM15273
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

5.95e-046902M47668
PathwayKEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION

MCM3 MCM4 MCM5

6.59e-0427903M47858
Pubmed

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

PANK3 PANK1 PANK2

4.64e-083126317379144
Pubmed

Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins.

MCM3 MCM4 MCM5

4.64e-08312637610039
Pubmed

Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.

PANK3 PANK1 PANK2

4.64e-083126317631502
Pubmed

Compartmentalization of mammalian pantothenate kinases.

PANK3 PANK1 PANK2

4.64e-083126323152917
Pubmed

Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

PANK3 PANK1 PANK2

1.85e-074126322815849
Pubmed

Coenzyme A metabolism.

PANK3 PANK1 PANK2

1.85e-07412632981478
Pubmed

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.

PANK3 PANK1 PANK2

1.85e-074126311479594
Pubmed

The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

MCM3 MCM4 MCM5

1.85e-07412638265339
Pubmed

Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.

RAF1 STK3 BRAF

4.62e-075126320212043
Pubmed

Human Mcm proteins at a replication origin during the G1 to S phase transition.

MCM3 MCM4 MCM5

9.21e-076126312364596
Pubmed

Pairwise interactions of the six human MCM protein subunits.

MCM3 MCM4 MCM5

9.21e-076126315236977
Pubmed

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.

MCM3 MCM4 MCM5

9.21e-076126321220507
Pubmed

The eukaryotic Mcm2-7 replicative helicase.

MCM3 MCM4 MCM5

9.21e-076126322918583
Pubmed

In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.

MCM3 MCM4 MCM5

9.21e-07612639099751
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYH7 MYO1D MYO5A MYO5B DSP STRBP CNTRL MCM5 CHD2 KRT79 HNRNPU TASOR2 NEFM STS IFT88 CHD5 CHD6 METTL25 DNAH6

1.13e-0614421261935575683
Pubmed

O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions.

MCM3 MCM4 MCM5

1.61e-067126330069701
Pubmed

Identification and characterization of a novel component of the human minichromosome maintenance complex.

MCM3 MCM4 MCM5

1.61e-067126317296731
Pubmed

Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.

MCM3 MCM4 MCM5

1.61e-067126311248027
Pubmed

Interaction of chromatin-associated Plk1 and Mcm7.

MCM3 MCM4 MCM5

1.61e-067126315654075
Pubmed

Binding of human minichromosome maintenance proteins with histone H3.

MCM3 MCM4 MCM5

1.61e-06712638798650
Pubmed

Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma.

RAF1 STK3 BRAF

1.61e-067126336038253
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

WAPL DSP STRBP MCM3 MCM4 HNRNPU TASOR2 LENG8 NCOR2 GTF2E2 SLF2 FIP1L1 DGCR8 UTP3 KNL1

2.04e-069541261536373674
Pubmed

FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.

MCM3 MCM4 MCM5

2.57e-068126323993743
Pubmed

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

MCM3 MCM4 MCM5

2.57e-068126316899510
Pubmed

Female-biased embryonic death from inflammation induced by genomic instability.

MCM3 MCM4 MCM5

2.57e-068126330787433
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

USP53 RAF1 DLG5 PANK3 DSP DENND4C TAB3 STK3 PANK2 BRAF SYNJ1 SLF2 FIP1L1 SSH2

3.11e-068611261436931259
Pubmed

Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.

MCM3 MCM4 MCM5

3.84e-069126310846177
Pubmed

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.

CAPN1 GRIN2C GRIN2D

3.84e-069126317526495
Pubmed

The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.

MCM3 MCM4 MCM5

3.84e-069126325049228
Pubmed

L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.

MCM3 MCM4 MCM5

3.84e-069126321149733
Pubmed

Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa.

MCM3 MCM4 MCM5

3.84e-069126330108253
Pubmed

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

MCM3 MCM4 MCM5

5.47e-0610126321055985
Pubmed

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.

RAF1 TG BRAF

5.47e-0610126318952847
Pubmed

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.

MCM3 MCM4 MCM5

5.47e-0610126316902406
Pubmed

Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.

MCM3 MCM4 MCM5

7.50e-0611126330100344
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

USP53 RAF1 MYO1E UNC5B JPH2 ITGA6 MTMR1 SLC7A11 BRAF SYTL4 SLC35A2

7.61e-065691261130639242
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

MYO1D MYO5A DSP RFX6 HNRNPU NEFM

8.66e-06131126628634551
Pubmed

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

MCM3 MCM4 MCM5

9.97e-0612126322474384
Pubmed

Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.

MCM3 MCM4 MCM5

9.97e-0612126324299456
Pubmed

Protein interaction and cellular localization of human CDC45.

MCM3 MCM4 MCM5

1.29e-0513126323364835
Pubmed

Interactions of the human MCM-BP protein with MCM complex components and Dbf4.

MCM3 MCM4 MCM5

1.29e-0513126322540012
Pubmed

Targets of Raf in tumorigenesis.

RAF1 BRAF

1.30e-052126220047953
Pubmed

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

RAF1 BRAF

1.30e-052126225096573
Pubmed

Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

RAF1 BRAF

1.30e-052126222826437
Pubmed

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.

RAF1 BRAF

1.30e-052126217018604
Pubmed

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

RAF1 BRAF

1.30e-052126215035987
Pubmed

Interactions of human nuclear proteins P1Mcm3 and P1Cdc46.

MCM3 MCM5

1.30e-05212627705359
Pubmed

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.

RAF1 BRAF

1.30e-052126215710605
Pubmed

BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.

RAF1 BRAF

1.30e-052126223517740
Pubmed

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

RAF1 BRAF

1.30e-052126225473895
Pubmed

Raf kinases in cancer-roles and therapeutic opportunities.

RAF1 BRAF

1.30e-052126221577205
Pubmed

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.

RAF1 BRAF

1.30e-052126222733131
Pubmed

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

GRIN2C GRIN2D

1.30e-052126229317596
Pubmed

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.

CAPN1 JPH2

1.30e-052126226063807
Pubmed

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.

RAF1 BRAF

1.30e-052126218794803
Pubmed

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.

GRIN2C GRIN2D

1.30e-052126233766086
Pubmed

The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation.

RAF1 HERC1

1.30e-052126230140388
Pubmed

Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.

DSP ITGA6

1.30e-052126233502623
Pubmed

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

GRIN2C GRIN2D

1.30e-052126229651654
Pubmed

MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma.

RAF1 STK3

1.30e-052126228677804
Pubmed

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.

GRIN2C GRIN2D

1.30e-052126231110197
Pubmed

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.

RAF1 BRAF

1.30e-052126223022482
Pubmed

Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer.

RAF1 BRAF

1.30e-052126222833462
Pubmed

Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.

RAF1 BRAF

1.30e-052126218205709
Pubmed

Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

GRIN2C GRIN2D

1.30e-052126235057644
Pubmed

[Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].

GRIN2D BRAF

1.30e-052126221915661
Pubmed

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

GRIN2C GRIN2D

1.30e-052126231786200
Pubmed

Epidermal RAF prevents allergic skin disease.

RAF1 BRAF

1.30e-052126227431613
Pubmed

RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.

RAF1 BRAF

1.30e-052126223680146
Pubmed

ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.

RAF1 BRAF

1.30e-052126216172610
Pubmed

MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.

MCM3 MCM4

1.30e-052126222354170
Pubmed

Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.

PANK3 PANK1

1.30e-052126216040613
Pubmed

BRAF inactivation drives aneuploidy by deregulating CRAF.

RAF1 BRAF

1.30e-052126220978199
Pubmed

Active Ras induces heterodimerization of cRaf and BRaf.

RAF1 BRAF

1.30e-052126211325826
Pubmed

A therapeutic approach to pantothenate kinase associated neurodegeneration.

PANK1 PANK2

1.30e-052126230352999
Pubmed

RAF inhibitors that evade paradoxical MAPK pathway activation.

RAF1 BRAF

1.30e-052126226466569
Pubmed

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

RAF1 BRAF

1.30e-052126226646323
Pubmed

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

RAF1 BRAF

1.30e-052126216364920
Pubmed

Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.

OLIG3 FIP1L1

1.30e-052126230157244
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

USP53 DLG5 MYO1D DSP CNTRL MCM3 MCM5 CEP164 TAB3 LENG8 MTMR14 SYNJ1 USP47

1.42e-058531261328718761
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO1E MYO5A MYO5B

1.64e-051412638022818
Pubmed

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

MCM3 MCM4 MCM5

2.05e-0515126310436018
Pubmed

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.

MCM3 MCM4 MCM5

2.05e-0515126319696745
Pubmed

The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

MCM3 MCM4 MCM5

2.51e-0516126311095689
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYO1D MYO5A DSP STRBP CAPN1 MCM4 MCM5 CHD2 TASOR2 NEFM USP47

2.72e-056531261122586326
Pubmed

Mapping of unconventional myosins in mouse and human.

MYO1D MYO1E MYO5A MYO5B

2.82e-054812648884266
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MYO1D MYO5A MYO5B DSP ITGA6 MTMR1 TAB3 NCOR2 PTPRB MTMR14 SSH2 UTP3 HERC1 KNL1

2.84e-0510491261427880917
Pubmed

Identification of proteins that may directly interact with human RPA.

MCM3 MCM4 MCM5

3.04e-0517126320679368
Pubmed

DNA replication in eukaryotic cells.

MCM3 MCM4 MCM5

3.64e-0518126312045100
Pubmed

Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib.

RAF1 BRAF

3.90e-053126224486585
Pubmed

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

RAF1 BRAF

3.90e-053126220130576
Pubmed

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.

GRIN2C GRIN2D

3.90e-05312629718984
Pubmed

Cytoskeletal heart-enriched actin-associated protein (CHAP) is expressed in striated and smooth muscle cells in chick and mouse during embryonic and adult stages.

MYH7 SYNPO2L

3.90e-053126221948713
Pubmed

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

RAF1 BRAF

3.90e-053126210454553
Pubmed

Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.

RAF1 BRAF

3.90e-053126214688025
Pubmed

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

RAF1 BRAF

3.90e-053126222510884
Pubmed

Human Rab small GTPase- and class V myosin-mediated membrane tethering in a chemically defined reconstitution system.

MYO5A MYO5B

3.90e-053126228939769
Pubmed

Expression of raf family proto-oncogenes in normal mouse tissues.

RAF1 BRAF

3.90e-05312621690378
Pubmed

Endothelial apoptosis in Braf-deficient mice.

RAF1 BRAF

3.90e-05312629207797
Pubmed

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.

MCM3 MCM5

3.90e-053126234449552
GeneFamilyMCM family

MCM3 MCM4 MCM5

8.25e-0698531085
GeneFamilyMyosins, class V

MYO5A MYO5B

6.53e-0538521100
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 BRAF

2.16e-0458521157
GeneFamilyPhosphoinositide phosphatases

MTMR1 MTMR14 SYNJ1

4.51e-04328531079
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2C GRIN2D

4.52e-0478521201
GeneFamilyMyosins, class I

MYO1D MYO1E

6.00e-0488521097
GeneFamilySynaptotagmin like tandem C2 proteins

SYTL4 SYTL5

9.59e-0410852822
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR1 MTMR14

2.20e-0315852903
GeneFamilyUbiquitin specific peptidases

USP53 USP9Y USP47

2.32e-0356853366
GeneFamilyDNA helicases

CHD2 PIF1

2.84e-03178521167
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 BRAF

5.64e-0324852654
GeneFamilyFibronectin type III domain containing

PTPRB EGFLAM IGSF9B USH2A

6.86e-03160854555
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#4

DLG5 MYO1D MYO5B DSP LMCD1 UNC5B SLC7A11 LPCAT2 TTLL10 SEMA3E

1.46e-0531612210Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K4
ToppCelldroplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DONSON MCM3 MCM4 MCM5 FIGNL1 PIF1 KNL1

1.10e-0618812670ec2a1b0505501ba18f10a5fce68c306a6292419
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAPOR2 RFX6 DENND4C SYTL4 IGSF9B HERC1

1.03e-051741266f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA6 MCM3 MCM4 MCM5 PTPRB FIGNL1

1.10e-051761266269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1D MYO5B DSP SPNS2 HEATR5A SEMA3E

1.29e-051811266b45b11428d13950369347e051d4d517efb2bd4fd
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 MCM3 MCM4 MCM5 KRT79 FIGNL1

1.37e-05183126642dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 LMCD1 JPH2 SYTL5 IGSF9B FRMPD3

1.60e-05188126661f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 LMCD1 JPH2 SYTL5 IGSF9B FRMPD3

1.60e-0518812667553ef7de3575af4cf34704b405b551c1af8eb83
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

DONSON ITGA6 MCM3 MCM4 MCM5 KNL1

1.70e-05190126684ee185939bdefb10705b621a70da27701eadcee
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

USP53 ADH1C FBXL7 LPCAT2 SYTL4 SSH2

1.70e-05190126612992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYD TG BRAF CD163L1 SSH2 EPB42

1.85e-051931266779276e775cb2492e8dd36436295a536084a6415
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM4 MCM5 KRT79 FIGNL1 PIF1

1.96e-051951266c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

KIF6 RAB17 C2orf15 TTLL10 DNAH6 SEMA3E

2.14e-0519812666d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MYO1D MYO5B DSP HEATR5A SYTL5 SEMA3E

2.20e-0519912661c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells|GW19 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM4 MCM5 STK3 PIF1 KNL1

2.26e-05200126631dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MYO1D MYO5B DSP HEATR5A SYTL5 SEMA3E

2.26e-052001266ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM4 MCM5 STK3 PIF1 KNL1

2.26e-05200126654174a485a82480726fa06efa6e050ddea77cb3c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DPYD DLG5 TG NLRP6 FBXL7

3.57e-05131126581efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCell(03)_Secretory-(1)_24hpi|(03)_Secretory / shred by cell type and Timepoint

UNC5B MCM3 MCM4 MCM5 FIGNL1

4.12e-0513512656e473296dfe1ff7a63d701e56920c0a1b043ddc6
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM4 MCM5 PTPRB FIGNL1

5.98e-0514612652d907e50206c4762a8baa741363bc7f0a04bd84e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF6 CFAP276 TTLL10 USH2A DNAH6

7.70e-0515412659ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF6 CFAP276 TTLL10 USH2A DNAH6

7.70e-05154126558072ce422d09f2de602580325eaac6c4ec6c136
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPLANE2 MCM3 MCM4 MCM5 CD163L1

8.96e-0515912658d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 MYO1D MYO1E UNC5B RFX6

8.96e-0515912655ca96db4281abb5f646150ccf36adc66ab201c78
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD9 MCM3 MCM4 MCM5 FIGNL1

1.04e-0416412655621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SPNS2 AMDHD2 MCM3 SYTL4 DNAH6

1.10e-041661265a697460dfe72e08fbf7d8e734a16b7dd2c6d86f9
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RAF1 FAM234A ITGA6 SLC7A11 TG

1.13e-0416712657e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM4 MCM5 CD163L1 FIGNL1

1.13e-04167126553e32d6687a07f486141df9f4ab998af4c03a507
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPLANE2 NUGGC MYO5A TG TTLL10

1.16e-041681265ce9fae8b295c668b0959d5007a8bcd401d80e258
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAPN1 MCM4 KRT79 SLC7A11 CHD5

1.16e-041681265a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP53 WIPI1 MYO5B STK3 IFT88

1.26e-041711265d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPLANE2 NUGGC MYO5A TG TTLL10

1.26e-041711265584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

SPNS2 ITGA6 FBXL7 PTPRB OR13A1

1.30e-041721265ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCelldroplet-Marrow-nan-24m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DONSON MYO1E MCM3 MCM4 FIGNL1

1.33e-04173126535dc897e06f905419d44093a92170d2cec35dd51
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KIF6 CFAP276 RAB17 OLIG3 DNAH6

1.33e-041731265a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCell(00)_Basal-(1)_24hpi|(00)_Basal / shred by cell type and Timepoint

MCM3 MCM4 MCM5 TG FIGNL1

1.33e-041731265a8e62e7d8baf6af691acd5c50deedbadc119ceba
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-CD45____plasma_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC WIPI1 MYO5A TG ADSS1

1.33e-04173126560e427f6c7d953cef5f692043670ff0b49cdce72
ToppCelldroplet-Marrow-nan-24m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DONSON MYO1E MCM3 MCM4 FIGNL1

1.33e-04173126537825d0dda028cf677ff6ff16ea58bff75cb25a7
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM4 MCM5 PTPRB FIGNL1

1.37e-041741265c988471207ba06195bc3e41056435e8c31c20bbe
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 JPH2 GRIN2D SYTL4 ADSS1

1.37e-041741265a9f34d1237f335d27c5560ff514368f4709f9144
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-plasma_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC WIPI1 MYO5A TG ADSS1

1.37e-041741265c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.37e-04174126566555c610251ea04f968c258e312d720c18e7cde
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

WIPI1 MYO1D MYO1E LMCD1 SLC7A11

1.40e-04175126589bf89466191da14896ed8928027f5b911436c22
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 JPH2 GRIN2D SYTL4 ADSS1

1.44e-041761265d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STRBP UNC5B SPNS2 MCM5 FIGNL1

1.44e-041761265a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MTMR1 MCM3 MCM4 MCM5 FIGNL1

1.48e-041771265f10f77130dbb2c0ad1b436ceb4fb1deac2b0267c
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB17 MCM3 MCM4 MCM5 PTPRB

1.48e-0417712650e74980a7686c31fcf1476b8f19a3392541df240
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.52e-04178126579823d13652177de852c2acce9159049241f1d86
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAPOR2 RFX6 DENND4C SYTL4 HERC1

1.52e-041781265fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_LGI2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC7A11 LPCAT2 SYTL5 EGFLAM FRMPD3

1.56e-0417912658dd10e3a9ab39d9a770cecac6e2ed3676b79e906
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC5B GRIN2C GRIN2D SYTL5 ADAMTS15

1.56e-0417912653b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellCiliated_cells-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

DLG5 CFAP276 ADH1C DNAH6 NEK11

1.56e-0417912651c41314b6fcfcac8d62034e7037570120d58f20f
ToppCelldroplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM5 FIGNL1 PIF1 KNL1

1.56e-04179126554621d2b3a66e62aa76b7e444118878ed97c1e02
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO5B DSP HEATR5A SYTL5 SEMA3E

1.56e-04179126504ce3673e46606f63d9c87bcba3a64c96817d812
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM4 MCM5 FIGNL1 PIF1 KNL1

1.69e-0418212650370b395ceb9d4d66f80cf60dd8c28ac60af5c7b
ToppCellPBMC-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

DONSON IGHV1-2 MCM3 MCM4 MCM5

1.69e-0418212654774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

KIF6 CFAP276 PLG TTLL10 DNAH6

1.69e-0418212657ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ELAPOR2 UNC5B FBXL7 PTPRB ADAMTS15

1.69e-04182126541b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ELAPOR2 UNC5B FBXL7 PTPRB ADAMTS15

1.69e-0418212655e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ELAPOR2 UNC5B FBXL7 PTPRB ADAMTS15

1.69e-041821265b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.73e-041831265769a022fe8568ec49e66f792cc5777e713a7571c
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.73e-041831265aac0695fafa59cabd920ee18b1139d3e00d898e8
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.77e-0418412651edefa2a049d7e22d0bdb1ea3d7ef1c8d6ae0fe3
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC5B GRIN2D FBXL7 SYTL5 PSKH2

1.77e-041841265e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.77e-0418412658578c50eaa8ce1cefc0228185c66c8e25f4bfc32
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

SPNS2 ITGA6 SLC7A11 STS SYTL5

1.77e-041841265d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM5 KRT79 FIGNL1 KNL1

1.82e-04185126557c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

MYO1E SPNS2 ITGA6 FBXL7 PTPRB

1.82e-041851265f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYO1E MYO5B LPCAT2 SYTL5 ADAMTS15

1.82e-041851265e87e6e097dc29ece8aea671935bde281b99b93ea
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1D MYO5B DSP SPNS2 SEMA3E

1.86e-0418612653aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

WAPL PANK3 OXR1 HEATR5A ZNF770

1.86e-04186126503db813598b67b1e08f759758a1c2023396921fa
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 SPNS2 SLC7A7 PTPRB DNAH6

1.91e-0418712653548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAB17 JPH2 SYTL5 IGSF9B FRMPD3

1.91e-041871265218c9b4f28499389c43005d9626af2ac01066027
ToppCelldroplet-Thymus-nan-18m-Myeloid-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB17 MYO1D DSP RHOU TTLL10

1.91e-041871265ed69e7cbd6fb59363b0e26f24887fc49405397ce
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 SPNS2 SLC7A7 PTPRB DNAH6

1.91e-041871265f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELAPOR2 MYO1D MYO5B DSP SPNS2

1.91e-04187126558d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 SPNS2 SLC7A7 PTPRB DNAH6

1.91e-04187126581754e965848b718be20ee97ce072ce426938a69
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAB17 JPH2 SYTL5 IGSF9B FRMPD3

1.91e-041871265c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH7 MYO5B DSP JPH2 FRMPD3

1.96e-0418812654db566f3f708e66730aa9e16f4d73d91dc534177
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

UNC5B SPNS2 ITGA6 FBXL7 PTPRB

1.96e-04188126502a62888e9db29d20133eeca1686d302545a39c9
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM4 MCM5 FIGNL1 KNL1

1.96e-04188126561ae7405ab56570409bf35382dc0a038e4137c15
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH7 MYO5B DSP JPH2 FRMPD3

1.96e-0418812656704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MYO5B DSP ITGA6 RFX6 UBXN2B

2.01e-0418912655d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WAPL DONSON MCM3 MCM5 FIGNL1

2.01e-04189126516dfc37d8d390ed7f927bc844c47c9c5a89a0928
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1E LMCD1 UNC5B ITGA6 PTPRB

2.01e-041891265c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WAPL DONSON MCM3 MCM5 FIGNL1

2.01e-0418912653ade3fa9369e85304b20d7233b581f18ad5ecc89
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD LMCD1 ADGRB2 JPH2 FBXL7

2.01e-0418912654dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYD LMCD1 ADGRB2 JPH2 FBXL7

2.01e-0418912650d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCelldroplet-Marrow-nan-24m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DONSON MCM3 MCM4 MCM5 FIGNL1

2.01e-04189126598ace332c3c046694c6ade47de8c8bf57ec51271
ToppCellfacs-GAT-Fat-24m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 UNC5B SPNS2 ITGA6 PTPRB

2.06e-041901265da2fcd4a2cc6e45c8174109d892f1424e39919a1
ToppCellfacs-GAT-Fat-24m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 UNC5B SPNS2 ITGA6 PTPRB

2.06e-0419012653395b2ff6ffadf84cdb1b5a37a5b6be05b56c30f
ToppCellfacs-Lung-nan-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF6 CFAP276 DNAH6 NEK11 SEMA3E

2.06e-041901265e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RAB17 MYO5B ITGA6 RFX6 UBXN2B

2.06e-041901265625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM4 MCM5 FIGNL1 KNL1

2.06e-041901265f5a8b44d9948a16e2d5284c78d8f7ed422ac623a
ToppCellfacs-GAT-Fat-24m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMCD1 UNC5B SPNS2 ITGA6 PTPRB

2.06e-041901265e584eaccbc22aa7f7a4340ed8a2a8b45ddca93f4
ToppCellfacs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF6 CFAP276 DNAH6 NEK11 SEMA3E

2.06e-041901265fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HGF MYO5B GRIN2D SYTL5 ADAMTS15

2.06e-0419012650acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM4 MCM5 FIGNL1 KNL1

2.06e-04190126508420f0ecd2c62e102371d16dcb8eda0d510e92a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HGF MYO5B GRIN2D SYTL5 ADAMTS15

2.06e-041901265e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCellCOVID-19-Heart-Mito_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH7 SYNPO2L FBXL7 PTPRB ADSS1

2.06e-041901265ea74e0e38bcaba125b48c88331e9ba09228d3178
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM5 FIGNL1 PIF1 KNL1

2.11e-04191126515dbc5a03bfab8931c0fd385b0f25874736ae874
DrugD-pantothenoyl-L-cysteine

PANK3 PANK1 PANK2

6.44e-0741253CID000440217
Diseasepantothenate kinase-associated neurodegeneration (implicated_via_orthology)

PANK3 PANK1 PANK2

2.82e-0741233DOID:3981 (implicated_via_orthology)
DiseaseCardiomyopathies

RAF1 HGF MYH7 DSP JPH2 BRAF FKTN

1.27e-061301237C0878544
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD2 CHD6 SEMA3E

2.44e-0671233DOID:0050834 (implicated_via_orthology)
DiseaseCardiomyopathy

MYH7 DSP JPH2 FKTN

4.46e-05471234cv:C0878544
DiseaseNoonan syndrome with multiple lentigines

RAF1 BRAF

5.16e-0531232cv:C0175704
Diseasecardiomyopathy (implicated_via_orthology)

RAF1 MYH7 JPH2 BRAF

2.25e-04711234DOID:0050700 (implicated_via_orthology)
DiseaseVACTERL association (implicated_via_orthology)

CPLANE2 TBC1D32

2.56e-0461232DOID:14679 (implicated_via_orthology)
Diseaseglucagon measurement, glucose tolerance test

UTP3 HERC1

2.56e-0461232EFO_0004307, EFO_0008463
DiseaseLeopard Syndrome 1

RAF1 BRAF

2.56e-0461232C4551484
DiseaseMalignant neoplasm of liver

RAF1 HGF MYO5B BRAF IFT88

3.30e-041421235C0345904
DiseaseLiver neoplasms

RAF1 HGF MYO5B BRAF IFT88

3.30e-041421235C0023903
DiseasePilomyxoid astrocytoma

RAF1 BRAF

3.57e-0471232C1519086
Diseaseprogressive familial intrahepatic cholestasis (is_implicated_in)

USP53 MYO5B

3.57e-0471232DOID:0070221 (is_implicated_in)
Diseasesarcoma (is_implicated_in)

PTPRB KNL1

4.75e-0481232DOID:1115 (is_implicated_in)
Disease1-ribosyl-imidazoleacetate measurement

WIPI1 DHTKD1

6.09e-0491232EFO_0800034
Disease2-hydroxyglutaric acid measurement

SLC46A2 ADAMTS15

6.09e-0491232EFO_0010446
DiseaseNoonan syndrome

RAF1 BRAF

6.09e-0491232cv:C0028326
DiseaseKidney Neoplasm

RAF1 BRAF FIGNL1

6.24e-04401233C0022665
DiseaseFamilial dilated cardiomyopathy

RAF1 MYH7 FKTN

8.26e-04441233C0340427
DiseaseMalignant neoplasm of kidney

RAF1 BRAF FIGNL1

8.83e-04451233C0740457
DiseaseNoonan Syndrome 1

RAF1 BRAF

9.25e-04111232C4551602
DiseaseTurner Syndrome, Male

RAF1 BRAF

9.25e-04111232C0041409
DiseaseFemale Pseudo-Turner Syndrome

RAF1 BRAF

9.25e-04111232C1527404
DiseaseNeuroblastoma

HGF CHD5 CHD6

1.00e-03471233C0027819
Diseasetryptophan betaine measurement

DPYD IFT88

1.11e-03121232EFO_0021017
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2C GRIN2D NCOR2

1.13e-03491233DOID:0060037 (implicated_via_orthology)
DiseaseAutosomal Dominant Myotubular Myopathy

MYH7 MTMR14

1.30e-03131232C3661489
DiseaseCentronuclear myopathy

MYH7 MTMR14

1.30e-03131232C0175709
DiseaseX-linked centronuclear myopathy

MYH7 MTMR14

1.30e-03131232C0410203
DiseaseMyopathy, Centronuclear, 1

MYH7 MTMR14

1.30e-03131232C4551952
DiseaseCongenital Structural Myopathy

MYH7 MTMR14

1.30e-03131232C0752282
DiseaseMyopathy, Centronuclear, Autosomal Dominant

MYH7 MTMR14

1.52e-03141232C1834558
DiseaseTubular Aggregate Myopathy

MYH7 MTMR14

1.52e-03141232C0410207
Diseasecongenital hypothyroidism (implicated_via_orthology)

TG NEFM

1.52e-03141232DOID:0050328 (implicated_via_orthology)
DiseaseRASopathy

RAF1 BRAF

1.75e-03151232cv:C5555857
DiseaseAutosomal Recessive Centronuclear Myopathy

MYH7 MTMR14

1.75e-03151232C3645536
DiseaseHypertrophic Cardiomyopathy

RAF1 MYH7 DSP

1.76e-03571233C0007194
DiseaseVascular Diseases

HGF SLC12A3

2.25e-03171232C0042373
DiseaseCongenital Fiber Type Disproportion

MYH7 MTMR14

2.52e-03181232C0546264
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RAF1 BRAF

2.81e-03191232C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

RAF1 BRAF

2.81e-03191232C1843181
DiseaseCardio-facio-cutaneous syndrome

RAF1 BRAF

2.81e-03191232C1275081
DiseaseCostello syndrome (disorder)

RAF1 BRAF

2.81e-03191232C0587248
Diseaseprostate adenocarcinoma (is_implicated_in)

RAF1 BRAF

3.12e-03201232DOID:2526 (is_implicated_in)
Diseaseseborrheic dermatitis

ELAPOR2 UNC5B

3.12e-03201232EFO_1000764
Diseasealpha-tocopherol measurement

HGF USH2A

3.12e-03201232EFO_0007898
DiseaseLEOPARD Syndrome

RAF1 BRAF

3.77e-03221232C0175704
DiseasePrimary familial hypertrophic cardiomyopathy

MYH7 JPH2

3.77e-03221232cv:C0949658
Diseasemelanoma

RAF1 CAPN1 RFX6 BRAF CD163L1

3.90e-032481235C0025202

Protein segments in the cluster

PeptideGeneStartEntry
AVSVGFTRTKGYGTS

ADGRB2

1051

O60241
GSLSGKALGSVVYVK

C2orf15

66

Q8WU43
GCSVKGLYEKVTGSG

FAM234A

286

Q9H0X4
TKYVGNNISTKGVGS

EPB42

411

P16452
QRIGSGSFGTVYKGK

BRAF

461

P15056
ATKDSGVGLKYSAST

CNTRL

1161

Q7Z7A1
SGKITVDDYGARTGK

EGFLAM

936

Q63HQ2
NGSYDGSSLVKSSGK

CHD5

1011

Q8TDI0
ASTAAGGIALKKSGF

TBC1D32

736

Q96NH3
QVSAKAAEKGYSVGG

AKAP4

806

Q5JQC9
GFSTGYGSAVKVAKV

ADH1C

176

P00326
GLSALGKKGDAISYA

CACFD1

136

Q9UGQ2
IAKRTTYGGVSGTAI

DPYD

756

Q12882
LSCGTALSTTGGKYI

CD163L1

941

Q9NR16
AKVNGSYEALSGGST

CAPN1

196

P07384
VTYGSGTASSKKLAK

DGCR8

551

Q8WYQ5
ATKFSTVKRYGGEGA

DHTKD1

181

Q96HY7
VVKGSLLRYSGTGTA

ADAMTS15

751

Q8TE58
TAATNGGYSRKKDGG

CFAP276

151

Q5T5A4
SVADTNKTKGGGYES

MTMR1

346

Q13613
LSTRIGSGSFGTVYK

RAF1

351

P04049
GSGSVGKSSLALRYV

RAB17

26

Q9H0T7
KDSDTGRSKGYGFIT

RBM23

296

Q86U06
SVYSGKGLTRFSGSK

RFX6

206

Q8HWS3
GGKVTAETEYGKTVT

MYH7

56

P12883
QYTSGKGSSAVGLTA

MCM4

531

P33991
PLKYDTGASTTGSKK

NCOR2

1456

Q9Y618
ASGSSYGGVKKSLGA

FIGNL1

316

Q6PIW4
GSKYNIAITAVSGGK

PTPRB

176

P23467
ASSKLGIKATSVYNG

KCTD9

31

Q7L273
KGRYGIRQSSSSGAK

JPH2

91

Q9BR39
LITDFGLAYSGKKSG

PSKH2

201

Q96QS6
KCSPIGVYTSGKGSS

MCM5

396

P33992
IGNTSGSKGSYSAKA

FSCB

31

Q5H9T9
YRAKDGSGTGGSKVE

MTMR14

41

Q8NCE2
SVDSGVSKGAYAGIT

GPBP1L1

76

Q9HC44
KISGTASKIGRTTAY

LIPT1

161

Q9Y234
LGSGKGYLSSFLSLK

METTL25

181

Q8N6Q8
ATKGGFSTNVGYSTV

KRT79

496

Q5XKE5
LASISKSGAAGGSAK

LENG8

46

Q96PV6
YGKLGLGNSTAKSSP

HERC1

4216

Q15751
GIVYDTGGLSIKGKT

NPEPL1

261

Q8NDH3
NIKTGGRVYGTTGTK

FIP1L1

121

Q6UN15
GRVYGTTGTKVKGVD

FIP1L1

126

Q6UN15
AGGRASYGVSKGKVC

HNRNPU

321

Q00839
SGEKGGIYVSKVTVG

DLG5

1366

Q8TDM6
GSGSFGTVYLVSDKK

NEK11

36

Q8NG66
SGKTFTITGGAERYS

KIF6

101

Q6ZMV9
TTGYGTKASGNKTVF

KNL1

376

Q8NG31
GKGRSYKGTVSITKS

HGF

131

P14210
YLGFSLDSGKGIVSK

ITGA6

296

P23229
SVKVSCKASGYTFTG

IGHV1-2

36

P23083
SKCGEGTYSLGSGIK

ELAPOR2

121

A8MWY0
SKYSTLTARVKGGDG

LMCD1

76

Q9NZU5
LSRAGAKAAGESSKY

OLIG3

56

Q7RTU3
SKDNYKRVTGTSLGG

PANK3

201

Q9H999
EYASIASSSKGGRIG

LPCAT2

366

Q7L5N7
SKDNYKRVTGTSLGG

PANK2

401

Q9BZ23
GKKGGYTSGTFRTVL

MCM3

246

P25205
GTGKHGTSLKTLYRT

OXR1

741

Q8N573
IDTASYKIFVSGKSG

CPLANE2

51

Q9BU20
LYKTGARAGTLSTTG

DNAH6

4111

Q9C0G6
ATGYGSKTSLASSIG

IFT88

66

Q13099
SSVSSFLKYVAGSKG

HEATR5A

826

Q86XA9
LGKKGATGASTTVYA

CHD2

271

O14647
NYKALAKGTRGSTSG

CHD2

736

O14647
GKGSTFAKASFVASG

CHD6

996

Q8TD26
GKQYGSEGKGSSSIS

FBXL7

6

Q9UJT9
GHLGKKESSYVGSVG

FRMPD3

526

Q5JV73
GSIAGASASPKEKYS

DSP

2016

P15924
SVYSASKGGLVGFSR

CBR4

146

Q8N4T8
STFVLTGSSAKKVYG

DENND4C

256

Q5VZ89
YLSTKNGAGLSKSKG

FKTN

31

O75072
KKETASGTSLGYGEE

DONSON

336

Q9NYP3
SGDKKGSSSSVYRLG

ETV3L

191

Q6ZN32
YSGELSGIRAGVKKS

UTP3

461

Q9NQZ2
GLGSGTLLSVSEYKK

NLRP6

106

P59044
VSGYSAGKSKLAGLL

OR13A1

281

Q8NGR1
SKDNYKRVTGTSLGG

PANK1

426

Q8TE04
FTGSAGTGKSYLLKR

PIF1

226

Q9H611
ALSGSSGYKFGVLAK

GTF2E2

66

P29084
KKYTLVSFGAAAGTG

SYNPO2L

306

Q9H987
AKAGGTSDSFVKGYL

SYTL4

541

Q96C24
AVKSGGTSDSFVKGY

SYTL5

601

Q8TDW5
TYKLEVKTGGGSSAS

USH2A

3746

O75445
VKTGGGSSASDDYIV

USH2A

3751

O75445
IYIALFGSTGAGKSS

NUGGC

101

Q68CJ6
GTTKKGIGPTYSSKA

ADSS1

161

Q8N142
GYSSASKIIFGSGTR

TRAJ3

1

A0A075B6Y3
GSGGEKGSHKYQRSS

TAB3

491

Q8N5C8
VNGDSISKIYAGTGA

SYNJ1

431

O43426
SYARSGGFSITGKIK

LMBRD2

131

Q68DH5
SSKGEIHGGSNGIYK

STS

351

P08842
GTTYEASGPSKKTAK

STRBP

426

Q96SI9
GSGLGYITGSSVKQA

SPNS2

241

Q8IVW8
KSNIKYGGSRLSITG

SLF2

71

Q8IX21
GKGYRGKRATTVTGT

PLG

486

P00747
AGVYFEKILKGSSGS

SLC35A2

216

P78381
SQGLKTSAYTKGLLG

CEP164

186

Q9UPV0
ITGKVKSDNGTGYDT

USP53

546

Q70EK8
GDGAVGKTSLVVSYT

RHOU

56

Q7L0Q8
SYAELGTTIKKSGGH

SLC7A11

96

Q9UPY5
GSYGSVFKAIHKESG

STK3

36

Q13188
KSKSFTGGGYRLGSS

UBXN2B

111

Q14CS0
SKGKGKYSGSEAGSL

SSH2

931

Q76I76
GASGKYQVSDGSLTV

IGSF9B

181

Q9UPX0
AELGTTIKKSGASYA

SLC7A7

91

Q9UM01
DIKKTHGGSSGSRGY

USP47

531

Q96K76
GKTYSRKGGNGSSKF

WAPL

6

Q7Z5K2
AISTNGKVKSGGTYF

SLC12A3

191

P55017
GKVKSGGTYFLISRS

SLC12A3

196

P55017
TILGSTAREKGKYSG

USP9Y

1361

O00507
KVKVYSSSTTGSGPG

UNC5B

481

Q8IZJ1
VGSLGKHGTYKTIGN

ZNF770

386

Q6IQ21
LLVVKASYGTGGSSN

SLC46A2

41

Q9BY10
SCASKVNGGRYGTTK

SEMA3E

381

O15041
AGQKGTKYLCASSVG

TASOR2

1116

Q5VWN6
TGTKAGYKLFSLSSV

WIPI1

31

Q5MNZ9
LAVRYASKKSGGSSK

MRPL27

26

Q9P0M9
YISSLKTSADGAKGG

TG

2721

P01266
IGGSNGATIISSYCK

TTLL10

161

Q6ZVT0
GSASYKLTFTAGGAI

WBP2

106

Q969T9
SGESGAGKTEASKYI

MYO1D

101

O94832
SGESGAGKTVAAKYI

MYO1E

111

Q12965
VSGESGAGKTVSAKY

MYO5A

161

Q9Y4I1
VSGESGAGKTVSAKY

MYO5B

161

Q9ULV0
DGLTAYVAGTKTLSG

AMDHD2

316

Q9Y303
VTIGSGKVFATTGYG

GRIN2C

746

Q14957
VTIGSGKVFATTGYG

GRIN2D

776

O15399
ITSEGGDGATKYITK

NEFM

861

P07197