Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 TEP1 ERVK-8

4.84e-0714964GO:0003964
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25

8.92e-0737965GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25

1.02e-0638965GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-8

1.73e-0511963GO:0004523
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 TEP1 ERVK-8

3.27e-0538964GO:0034061
GeneOntologyMolecularFunctionO-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

LFNG MFNG

6.84e-053962GO:0033829
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8

1.35e-0421963GO:0035613
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE3 SYNE2

2.27e-045962GO:0140444
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERN2 ERVK-8

5.72e-0479964GO:0004521
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-8

7.43e-0437963GO:0016891
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ERVK-7 TEP1 ERVK-8 GMPPB

8.38e-04152965GO:0016779
GeneOntologyMolecularFunctionchondroitin sulfate binding

RTN4R AGRN

1.22e-0311962GO:0035374
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-8

1.41e-0346963GO:0016893
GeneOntologyMolecularFunctiondystroglycan binding

PLEC AGRN

1.46e-0312962GO:0002162
Domain-

FBXO3 POLDIP2

2.19e-0528822.60.40.1470
DomainAPAG

FBXO3 POLDIP2

2.19e-052882PS51087
DomainApaG_domain

FBXO3 POLDIP2

2.19e-052882IPR007474
DomainDUF525

FBXO3 POLDIP2

2.19e-052882PF04379
DomainFringe

LFNG MFNG

6.56e-053882IPR017374
DomainWD40_repeat_CS

FBXW9 TEP1 CFAP52 WDR97 WDR12 HERC1

1.25e-04164886IPR019775
DomainKASH

SYNE3 SYNE2

1.31e-044882PF10541
DomainKASH

SYNE3 SYNE2

1.31e-044882IPR012315
DomainKASH

SYNE3 SYNE2

1.31e-044882PS51049
DomainKASH

SYNE3 SYNE2

1.31e-044882SM01249
Domain-

SEMA6C FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

1.75e-043338882.130.10.10
DomainWD40/YVTN_repeat-like_dom

SEMA6C FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

1.82e-04335888IPR015943
DomainFringe-like

LFNG MFNG

2.17e-045882IPR003378
DomainFringe

LFNG MFNG

2.17e-045882PF02434
DomainWD40

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

2.73e-04268887SM00320
DomainWD40_repeat

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

2.99e-04272887IPR001680
DomainSpectrin_repeat

SYNE3 SYNE2 PLEC

3.38e-0429883IPR002017
DomainWD_REPEATS_1

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

3.41e-04278887PS00678
DomainWD_REPEATS_2

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

3.48e-04279887PS50082
DomainWD_REPEATS_REGION

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

3.48e-04279887PS50294
DomainSpectrin/alpha-actinin

SYNE3 SYNE2 PLEC

4.54e-0432883IPR018159
DomainSPEC

SYNE3 SYNE2 PLEC

4.54e-0432883SM00150
DomainWD40_repeat_dom

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

5.07e-04297887IPR017986
DomainLaminin_G_1

EYS AGRN

1.17e-0311882PF00054
DomainWD40

FBXW9 TEP1 CFAP52 WDR97 WDR12 HERC1

1.41e-03259886PF00400
DomainHEAT

MROH1 PRKDC HTT

1.50e-0348883PF02985
DomainHEAT

MROH1 PRKDC HTT

2.59e-0358883IPR000357
DomainHEAT_REPEAT

MROH1 PRKDC HTT

4.41e-0370883PS50077
Domain-

GLB1L2 BTBD9 EPHB1

4.96e-03738832.60.120.260
DomainActinin_actin-bd_CS

SYNE2 PLEC

5.21e-0323882IPR001589
DomainPentatricopeptide_repeat

PRKDC HTT

5.21e-0323882IPR002885
DomainSpectrin

SYNE3 SYNE2

5.21e-0323882PF00435
DomainACTININ_2

SYNE2 PLEC

5.21e-0323882PS00020
DomainACTININ_1

SYNE2 PLEC

5.21e-0323882PS00019
DomainHECT

HUWE1 HERC1

7.14e-0327882PF00632
DomainHECTc

HUWE1 HERC1

7.14e-0327882SM00119
DomainHECT_dom

HUWE1 HERC1

7.14e-0327882IPR000569
DomainHECT

HUWE1 HERC1

7.14e-0327882PS50237
Domainfn3

SDK2 SPEG PTPRB EPHB1

7.23e-03162884PF00041
DomainCys-rich_flank_reg_C

RTN4R CHADL AMIGO2

8.84e-0390883IPR000483
DomainLRRCT

RTN4R CHADL AMIGO2

8.84e-0390883SM00082
DomainARM-like

HUWE1 MROH1 RIC8A PRKDC HTT

9.00e-03270885IPR011989
DomainLeu-rich_rpt

CARMIL3 RTN4R CHADL LRRC71 AMIGO2

9.13e-03271885IPR001611
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA6C NDST1 SPEG PIEZO1 TRMT1 CFAP43 HUWE1 HES2 TEP1 DUS1L SYNE3 MROH1 RIC8A PRKDC PLEC HERC1 DHX34 AGRN HTT

2.88e-101105991935748872
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

2.23e-07599312629516
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE3 SYNE2 PLEC

4.45e-07699318827015
Pubmed

p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.

SYNE3 SYNE2 PLEC

4.83e-061299328595999
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

4.83e-061299314557543
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25

7.58e-069499521542922
Pubmed

Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment.

OPN4 HTT

8.02e-06299230587542
Pubmed

Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis.

SYNE3 PLEC

8.02e-06299223761073
Pubmed

Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.

DNHD1 PLK1

8.02e-06299221507953
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

8.02e-0629929060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

8.02e-0629929460924
Pubmed

Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12.

LFNG MFNG

8.02e-0629929878264
Pubmed

Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans.

RTN4R NUS1

8.02e-06299212378589
Pubmed

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.

SPEG RYR2

8.02e-06299232683896
Pubmed

DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.

PRKDC PLK1

8.02e-06299224166892
Pubmed

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

PRKDC PLK1

8.02e-06299224844881
Pubmed

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.

PRKDC PLK1

8.02e-06299225925375
Pubmed

Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington's disease.

RYR2 HTT

8.02e-06299232897880
Pubmed

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.

CD28 PRKDC

2.40e-05399217055754
Pubmed

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

LFNG MFNG

2.40e-05399225808869
Pubmed

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

LFNG MFNG

2.40e-05399226608918
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

2.40e-05399210516026
Pubmed

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.

LFNG MFNG

2.40e-05399216221665
Pubmed

Fringe is a glycosyltransferase that modifies Notch.

LFNG MFNG

2.40e-05399210935626
Pubmed

Differential expression pattern of the three Fringe genes is associated with epidermal differentiation.

LFNG MFNG

2.40e-0539929804358
Pubmed

Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.

LFNG MFNG

2.40e-05399212486116
Pubmed

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.

HUWE1 PRKDC

2.40e-05399232457294
Pubmed

Cloning of mammalian Ire1 reveals diversity in the ER stress responses.

ERN2 PLK1

2.40e-0539929755171
Pubmed

Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.

STIM1 PTPRB

2.40e-05399228385807
Pubmed

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.

SYNE3 SYNE2

2.40e-05399223336069
Pubmed

Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.

LFNG MFNG

2.40e-05399222081605
Pubmed

STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes.

RYR2 STIM1

2.40e-05399226261328
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

EFCAB5 CARMIL3 PIEZO1 DACT2 GLB1L2 PSTPIP1 ESYT3 ERVK-25 DHX34

2.92e-0555299910737800
Pubmed

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

PIEZO1 CD28 RIC8A CCR7 NCKAP1L

3.92e-0513299526439863
Pubmed

Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.

LFNG MFNG

4.79e-05499219026002
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7

4.79e-05499210469592
Pubmed

Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.

LFNG MFNG

4.79e-05499229629872
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

4.79e-0549927983737
Pubmed

Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.

GMPPB AMIGO2

4.79e-05499212843293
Pubmed

Congenital Myasthenic Syndromes Overview

PLEC GMPPB AGRN

5.55e-052699320301347
Pubmed

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.

LFNG MFNG

7.98e-05599211346656
Pubmed

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.

LFNG MFNG

7.98e-0559929207795
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

7.98e-05599211401426
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE3 SYNE2

7.98e-05599218396275
Pubmed

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

PRKDC PLK1

7.98e-05599215664519
Pubmed

CD45RA-Foxp3(high) activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28+central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis.

CD28 CCR7

7.98e-05599223747721
Pubmed

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.

CD28 PRKDC

1.19e-04699216081804
Pubmed

Demarcation of early mammalian cortical development by differential expression of fringe genes.

LFNG MFNG

1.19e-04699210675782
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

1.19e-04699215063128
Pubmed

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.

LFNG MFNG

1.19e-04699219217325
Pubmed

Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.

LFNG MFNG

1.19e-04699228089369
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE3 SYNE2

1.19e-04699233058875
Pubmed

Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.

OPN4 PIEZO1

1.67e-04799238733989
Pubmed

Mapping a chromosomal locus for valproic acid-induced exencephaly in mice.

ERN2 PLK1

1.67e-04799215170225
Pubmed

Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.

LFNG MFNG

1.67e-04799219479951
Pubmed

Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.

CD28 CCR7

2.22e-04899228550204
Pubmed

Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes.

LFNG MFNG

2.22e-04899210341080
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SEMA6C MROH1 WDR97 GMPPB

2.55e-0410799411347906
Pubmed

Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium.

LFNG MFNG

2.85e-04999217605079
Pubmed

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.

LFNG MFNG

2.85e-04999215574878
Pubmed

Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the  receptor protein of CRL2Prame complex.

FBXW9 BTBD9 FBXO3

3.53e-044899333504946
Pubmed

Real-time resolution of point mutations that cause phenovariance in mice.

KBTBD2 PRKDC

3.56e-041099225605905
Pubmed

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

BBS5 PLK1

3.56e-041099227979967
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

3.56e-041099212970426
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

LFNG MFNG

4.34e-041199210878608
Pubmed

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

SYNE3 SYNE2

4.34e-041199222826121
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

LFNG MFNG

4.34e-04119929187150
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

HUWE1 PRKDC PLEC GMPPB HTT NCKAP1L

4.64e-0434499630333137
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DNHD1 EFCAB5 SDK2 PLEC HERC1

5.65e-0423499536243803
Pubmed

Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.

HUWE1 PRKDC

6.13e-041399229285303
Pubmed

USP7 controls NGN3 stability and pancreatic endocrine lineage development.

SPEG HUWE1 PLEC

6.16e-045899337117185
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

HUWE1 PRKDC PLEC HERC1

6.67e-0413899423438482
Pubmed

Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.

STIM1 ESYT3

7.14e-041499227399837
Pubmed

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

LFNG MFNG

7.14e-041499223806616
Pubmed

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.

NDST1 RALGAPB USHBP1 RIC8A

7.42e-0414299430232004
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

EFCAB5 PCDHGB2 DACT2 VPS36 RYR2 AAR2 MFNG SLC22A14 SYNE2 PRKDC PLEC AMIGO2

8.16e-041442991235575683
Pubmed

BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

LFNG MFNG

8.22e-041599216324690
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

LFNG MFNG

8.22e-041599212971992
Pubmed

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.

LFNG MFNG

8.22e-041599227966429
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

LFNG MFNG

8.22e-041599212167404
Pubmed

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

PRKDC PLK1

9.38e-041699226291670
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

LFNG MFNG

9.38e-041699212617809
Pubmed

Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.

WDR12 PRKDC

9.38e-041699218258596
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

RTEL1 PLEC AGRN HTT

9.57e-0415299434299191
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

RTEL1 HUWE1 HERC1 PLK1

1.08e-0315799430686591
Pubmed

Lunatic fringe null female mice are infertile due to defects in meiotic maturation.

LFNG MFNG

1.19e-031899215659488
Pubmed

Lunatic fringe potentiates Notch signaling in the developing brain.

LFNG MFNG

1.33e-031999220510365
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

HUWE1 PRKDC PLEC

1.35e-037699327542412
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

RTN4R BBS5 NCOA4 AAR2 FBXO3 SYNE2 RIC8A PLEKHH2

1.38e-0375099811230166
Pubmed

Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.

LFNG MFNG

1.47e-032099237369584
Pubmed

Sequential Notch activation regulates ventricular chamber development.

LFNG MFNG

1.79e-032299226641715
Pubmed

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

PRKDC PLEC AGRN

1.80e-038499325670202
Pubmed

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

HUWE1 SYNE2 PLK1

1.87e-038599319596235
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXW9 HUWE1 FBXO3

1.87e-038599319028597
Pubmed

Notch signalling regulates epibranchial placode patterning and segregation.

LFNG MFNG

1.95e-032399231988190
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

FBXW9 HUWE1 FBXO3

2.20e-039099335671810
Pubmed

Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.

TEP1 STIM1

2.31e-032599211698278
Pubmed

The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.

LFNG MFNG

2.49e-032699224391519
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HUWE1 HERC1

2.49e-032699226949039
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

BCORL1 SH2D3A HUWE1 PLK1 GMPPB

2.61e-0333199519490893
InteractionNEUROG3 interactions

RTEL1 SPEG NOL9 HUWE1 TEP1 PLEC HERC1

5.43e-06149927int:NEUROG3
InteractionTOP3B interactions

SEMA6C NDST1 RTEL1 SPEG PIEZO1 TRMT1 CFAP43 HUWE1 HES2 TEP1 DUS1L SYNE3 MROH1 RIC8A PRKDC PLEC HERC1 DHX34 AGRN HTT

8.30e-0614709220int:TOP3B
GeneFamilyWD repeat domain containing

FBXW9 CFAP43 TEP1 CFAP52 WDR97 WDR12 HERC1

1.57e-05262567362
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE3 SYNE2

5.63e-0545621252
GeneFamilyBeta 3-glycosyltransferases

LFNG MFNG

2.49e-0324562426
ToppCell15-Airway-Epithelial-Multiciliated_precursor|Airway / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 CFAP52 CCDC157 LRRC71

2.02e-06178936d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP73 CFAP43 BBS5 GLB1L2 LRRC71 FAM149A

2.15e-0618093692fb01b91261b3103454924cde56add337b41844
ToppCell18-Distal-Epithelial-Multiciliated_precursor|Distal / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 CFAP52 CCDC157 LRRC71

2.60e-0618693658ab1360a1730655a5939295ba05997ac4a2d14e
ToppCellICU-SEP-Lymphocyte-T_NK-CD8_Naive|ICU-SEP / Disease, Lineage and Cell Type

RTEL1 CD28 CCR7 PLEKHH2 PLK1

1.53e-05149935a66f3ebf6214b269b137ddd5f4d8d7fb3ef2d962
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EFCAB5 CFAP73 CADM2 CCR7 USP54

1.69e-05152935ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 GLB1L2 CFAP52 LRRC71

1.85e-051559355f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 GLB1L2 CFAP52 LRRC71

1.85e-051559350944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EFCAB5 CFAP73 CADM2 CCR7 USP54

2.16e-0516093519105debef96ea0c267d6a1d332303ec668ae47e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CD28 CCR7 SYTL1 NCKAP1L

2.22e-0516193554eda81a570e422b35fcea799e640c7654122969
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 LFNG CD28 CCR7 SYTL1

2.29e-0516293558fe827198c172eeaa26273b0fad7991a718b0bf
ToppCellCiliated_cells-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CHADL CFAP43 ERN2 LRRC71

2.57e-051669354b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHADL PSTPIP1 SYNE3 SYTL1 PLK1

2.73e-05168935a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCell15-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 CFAP52 LRRC71

2.80e-05169935425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATG9B PSTPIP1 MFNG CD28 SYTL1

3.05e-05172935425970e9ce8943f7e2ba6ca958e7a3a29baa798c
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATG9B PSTPIP1 MFNG CD28 SYTL1

3.05e-05172935ca0cc0e92b6cdce5016f18fcb2ec1508cb222502
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCORL1 PTPRB USHBP1 SYNE2 PLK1

3.22e-051749359d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCORL1 PTPRB USHBP1 SYNE2 PLK1

3.22e-0517493553cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ATG9B CFAP73 GLB1L2 CFAP52 LRRC71

3.22e-05174935b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ATG9B CFAP73 GLB1L2 CFAP52 LRRC71

3.22e-0517493500cf27bc23af1472a507be31fba6245a8fdd901b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATG9B CFAP73 CFAP43 WDR97 LRRC71

3.59e-051789353b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIEZO1 MFNG PTPRB USHBP1 EPHB1

3.69e-05179935abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIEZO1 MFNG PTPRB USHBP1 EPHB1

3.69e-051799350b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP73 CFAP43 CFAP52 CCDC157 LRRC71

3.89e-05181935dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCelldroplet-Fat-Scat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 MFNG PTPRB USHBP1 EPHB1

3.99e-05182935fea094fe0e7796c084e60b5310c1559658633f7a
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 CFAP52 LRRC71

4.32e-051859350998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCell15-Distal-Immune-Hematopoietic,_T_Cells|Distal / Age, Tissue, Lineage and Cell class

MFNG EYS CD28 CCR7 NCKAP1L

4.32e-05185935481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATG9B CFAP73 CFAP43 CFAP52 LRRC71

4.43e-05186935903af26a63ec4b1755ab5cb81dfeb8dbd14bc5db
ToppCell18-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 CFAP52 LRRC71

4.54e-051879358d7fa6b2950898e7f283401808378ba2a41b9651
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPATA6 CFAP73 BBS5 CFAP52 LRRC71

5.15e-0519293503acd4a26b986e34eee608747347791122f1aa52
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPATA6 CFAP73 BBS5 CFAP52 LRRC71

5.15e-0519293531c6046589e2fbb0486fd044c5b128099d37872f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DACT2 CD28 SYNE2 CCR7 SYTL1

5.28e-051939357deb439943d35a4e825674b2b7dcddb45d366ad1
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

CFAP73 CFAP43 CFAP52 SYNE2 USP54

5.54e-05195935fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

CFAP73 CFAP43 CFAP52 SYNE2 USP54

5.54e-05195935eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IFNK CFAP73 CFAP43 CFAP52 LRRC71

5.96e-05198935f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

PTPRB CD28 SYNE2 CCR7 PLK1

5.96e-05198935ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-CD8+_T_naive|ICU-SEP / Disease, condition lineage and cell class

RTEL1 CD28 CCR7 PLEKHH2 PLK1

6.10e-05199935ae5936ff37a333d66840dd1dfc59c4ce750625cd
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Npw|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RTN4R DACT2 OTOP3 PSTPIP1

9.27e-05113934165de4316059222f33d1e51aeff4554037c0b937
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OPN4 PCDHGB2 SYTL1

1.30e-04479330346616865ba7e1bf6f900c28da366578b9c0c73
ToppCellTCGA-Endometrium|World / Sample_Type by Project: Shred V9

CFAP73 DACT2 CCDC157 LRRC71

1.59e-04130934101d9bf4bdf10c4f5e852067297a3bc6e735d794
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

2.62e-04148934d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

2.62e-04148934c8e93b87212f55774223caa385859c566fa1981f
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

2.82e-0415193481cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

2.82e-041519349cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Cholinergic_cortical__interneurons)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CFAP73 OTOP3 GLB1L2

2.96e-0462933d63e8417192ebe5d44f0868c5991d28c83bfd75d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Cholinergic_cortical__interneurons)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CFAP73 OTOP3 GLB1L2

2.96e-0462933faf2f54e6ddb34f342ce18470fb44b3a5b1d4139
ToppCellCiliated_cells-A-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CFAP43 CFAP52 LRRC71

3.04e-041549343b938e23324f7edb56797b4a76fb96ff588142cf
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

3.04e-041549344e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

3.04e-041549349ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

3.04e-041549347556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

3.04e-0415493458072ce422d09f2de602580325eaac6c4ec6c136
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK|Thalamus / BrainAtlas - Mouse McCarroll V32

PIEZO1 MFNG PTPRB USHBP1

3.12e-04155934fe6c4aba0e98cda84bf178aeac2e9fa834477f22
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

CFAP73 CFAP43 ESYT3 SYNE2

3.19e-0415693410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellsevere-CD4+_T_naive|World / disease stage, cell group and cell class

HES2 EYS SYNE3 CCR7

3.27e-04157934ccf9abe0b59e9ea728cec4bba1872ffe14c7385c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNHD1 RYR2 PLEKHH2 DHX34

3.35e-041589347f5426585d0d299d2b48e5fcb349950feffdef33
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB5 OPN4 ERN2 PLEKHH2

3.35e-04158934f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB5 OPN4 ERN2 PLEKHH2

3.35e-041589348c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSTPIP1 SEC22C WDR12 DHX34

3.43e-04159934f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCellCiliated_cells-B-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CFAP43 CFAP52 LRRC71

3.69e-041629345319603f7ba3f48126dcf2ba9ae604be11bf2577
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

ERN2 CADM2 RYR2 EYS

3.77e-0416393419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellCiliated_cells-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CFAP43 CFAP52 LRRC71

3.77e-0416393443194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell10x5'-Lung-Lymphocytic_T_CD8-Tnaive/CM_CD8|Lung / Manually curated celltypes from each tissue

ATG9B FBXO3 CCR7 LRRC71

3.77e-04163934c8e4440d1a857e4da83002303940dd42b273c92e
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP73 CFAP43 CFAP52 LRRC71

3.86e-04164934e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CFAP43 CFAP52 LRRC71

3.86e-041649340e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTEL1 SPEG SEC22C PRKDC

3.95e-04165934475905d608fac628960188ae4a18010b8097417e
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

PIEZO1 MFNG PTPRB USHBP1

3.95e-041659347d319a112b9062efee428bef6f4534d2ce782e04
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CD28 SYTL1 NCKAP1L

4.04e-04166934d80c2522cf314d56730d60f160b1247933443378
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CCR7 SYTL1 NCKAP1L

4.04e-04166934b7027802cac6ebf3c4a19ef11c9164d92694a4eb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CD28 SYTL1 NCKAP1L

4.04e-04166934f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CCR7 SYTL1 NCKAP1L

4.04e-04166934dbb73742db00982539b1800aef8af2801b3a0598
ToppCellIonocyte-iono-3|World / Class top

DNHD1 RTEL1 RTN4R PLK1

4.04e-041669349c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CD28 CCR7 NCKAP1L

4.04e-0416693400c53ee34ff4b988a9accd296bc0a2e14d9e7c49
ToppCell15-Distal-Epithelial-Multiciliated_precursor|Distal / Age, Tissue, Lineage and Cell class

ATG9B CFAP73 CFAP43 LRRC71

4.13e-04167934442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCellCiliated_cells-A-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

CFAP73 CFAP43 CFAP52 CCDC157

4.13e-04167934edb722ee9b6ccd00fb038f702be8664020932659
ToppCelldroplet-Bladder-nan-24m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 CD28 CCR7 NCKAP1L

4.23e-04168934c6e0daa790dd5db20dd1ab8c1e7142484976d743
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

MTRF1 DPPA4 CCDC157 EPHB1

4.23e-041689345a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNHD1 MFNG SEC22C LRRC71

4.32e-041699348a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-7|TCGA-Lung / Sample_Type by Project: Shred V9

GLB1L2 BTBD9 ESYT3 FAM149A

4.32e-041699345f522a10b6ec24a353f53bec2f779a81cd5f9581
ToppCellFrontal_cortex-Neuronal-Inhibitory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SEMA6C ATG9B CARMIL3 ASIC4

4.32e-0416993478eb70dd916724e476eabccf18fb7fcec4210308
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHADL LFNG CD28 CCR7

4.42e-0417093490f7640f04672c800cb28aea50004b1bb0565e8a
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTEL1 SEC22C CD28 CCR7

4.42e-041709343ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA6C CFAP73 GLB1L2 LRRC71

4.52e-041719341854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP73 CFAP43 CFAP52 LRRC71

4.52e-041719344f2a83d8091f1fd29542d2e5add57fd482e921b5
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CARMIL3 EYS ASIC4 AMIGO2

4.52e-04171934dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell390C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MTRF1 DPPA4 CCDC157 EPHB1

4.62e-041729343f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Deuterosomal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFAP73 HES2 CFAP52 LRRC71

4.62e-0417293408ad76412c9cc3504141797b44b88478ced87476
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

SPATA6 CHADL ERN2 LFNG

4.72e-04173934d4cbeae262abfa30d8c5452285d3261a96875610
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PTPRB USHBP1 AGRN EPHB1

4.83e-04174934b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell10x5'-Liver-Lymphocytic_T_CD8-Tnaive/CM_CD8|Liver / Manually curated celltypes from each tissue

ATG9B SPEG EYS CCR7

4.83e-0417493403918ca51ae3b4c9c1a74769b08ea23f518286ba
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE3 GNRH2 LRRC71 NCKAP1L

4.93e-04175934e991ffa4d1d278a011592b9915cd35fe76db20cc
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFNG PTPRB USHBP1 PLEC

5.04e-0417693477516048aefbe1f48e825052756df0c310c1c486
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE3 CCR7 SYTL1 NCKAP1L

5.04e-04176934274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell390C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

MTRF1 DPPA4 CCDC157 EPHB1

5.04e-04176934aab9603b7943b7f7243eb6190ebba998566196f3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB WDR97 ZNF74 PLEC

5.04e-041769341df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE3 CCR7 SYTL1 NCKAP1L

5.04e-04176934d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFNG PTPRB USHBP1 PLEC

5.04e-0417693496779273b94345250cf53ba671203345b43d9e00
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD28 SYNE2 CCR7 SYTL1

5.15e-0417793428f2ea29a52de90301e6ba770f407ee4034936d5
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

CFAP73 TRMT1 CHADL CCR7

5.15e-04177934eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_Exhausted|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD28 SYNE2 CCR7 SYTL1

5.15e-04177934f87bbc9403e909bb534eb705bcd2bca83d072cc7
ToppCell3'-Adult-LargeIntestine-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFNG CD28 CCR7 NCKAP1L

5.26e-04178934307b6e21bc69a0310c550f1fafa8600285e99ccd
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFNG PTPRB USHBP1 EPHB1

5.26e-041789346bef4ef48f649c6e38ae732bc08e6d7814db588b
DiseaseMyasthenic Syndromes, Congenital

PLEC GMPPB AGRN

5.48e-0524913C0751882
Diseaseretinitis pigmentosa (implicated_via_orthology)

OPN4 DACT2 EYS

7.87e-0527913DOID:10584 (implicated_via_orthology)
Diseasepalmitoyl dihydrosphingomyelin (d18:0/16:0) measurement

SYNE2 GLTPD2

1.96e-047912EFO_0800400
Diseaselevel of Sphingomyelin (d34:0) in blood serum

SYNE2 GLTPD2

5.08e-0411912OBA_2045176
DiseaseAutosomal Recessive Centronuclear Myopathy

SPEG STIM1

9.62e-0415912C3645536
Diseaselevel of Sphingomyelin (d40:2) in blood serum

SYNE2 GLTPD2

2.28e-0323912OBA_2045181
Diseasevitronectin measurement

EFCAB5 POLDIP2

2.28e-0323912EFO_0021843
Diseaseosteoarthritis, hip

PIEZO1 CHADL PLEC

2.92e-0392913EFO_1000786

Protein segments in the cluster

PeptideGeneStartEntry
LAERNAWLRLALSSR

USHBP1

176

Q8N6Y0
NDTTSGRLHLRLEWL

ESYT3

411

A0FGR9
RILWHSLALSRVNVS

BBS5

56

Q8N3I7
HWLLIQDASTRLRAL

CFAP43

1106

Q8NDM7
STFNWQHRILLVRAR

ERVK-19

416

O71037
STFNWQHRILLVRAR

ERVK-8

416

Q902F8
IFWVRSKRSRLLHSD

CD28

176

P10747
LHQRGLTVLRWSTLR

AAR2

81

Q9Y312
RLELSRHWRRGTLSV

AGRN

1456

O00468
SLLSQGRRHLWRARE

BCORL1

1286

Q5H9F3
SDRARWIVALTHSER

ARHGEF16

606

Q5VV41
QLRQWSSCRHIRRSS

CCR7

351

P32248
ALLASWARISARART

DPPA4

201

Q7L190
DQSELAWRLLSRRHG

DUS1L

26

Q6P1R4
RLWSDSRHSRQVLLL

AMIGO2

261

Q86SJ2
RNVSTVHRDFRLWLI

DNHD1

4196

Q96M86
ALRLWTQLQELRREH

CFAP73

116

A6NFT4
RRFWDSLLRLGTLHQ

CCDC157

121

Q569K6
VVQLRERHWRIFSLS

POLDIP2

276

Q9Y2S7
WLLTTFINRRGAHRI

EPHB1

71

P54762
FDRLTILRNALWVHS

PSTPIP1

221

O43586
RNLLKSHLNLDDRRW

NOL9

196

Q5SY16
KSWLVRHFSLLLRRD

OTOP3

66

Q7RTS5
RDLVSDHVTWRLRAL

FBXW9

111

Q5XUX1
LRITENSTRHLSFRW

PTPRB

1091

P23467
HRARLDLLLETWISR

LFNG

126

Q8NES3
SLISRREHWRLLSPS

EYS

1476

Q5T1H1
RTLLLLHRALRWSQL

GLTPD2

181

A6NH11
EWTRRSLHLRVLGRQ

FAM149A

311

A5PLN7
VSARLLEHLWRRAAS

HES2

111

Q9Y543
LTLARDTLHFLALRW

ERN2

246

Q76MJ5
VLRDARIRSHSWLES

GMPPB

291

Q9Y5P6
TIQLIRILHRTDRWT

HERC1

2216

Q15751
EDRVLALTSWRLHLF

CARMIL3

41

Q8ND23
IRVWHTSSNRELLRI

CFAP52

356

Q8N1V2
RRLSQLSSHDPLWRR

FBXO3

41

Q9UK99
ISLRLRLSSRSDAWD

PCDHGB2

711

Q9Y5G2
LCLHRTLTSWLRVRF

NUS1

16

Q96E22
LELDRWSLRQHISER

KBTBD2

556

Q8IY47
SHLEARLNRAIVWLA

NCKAP1L

711

P55160
LVRFLHSWTNLRLQT

NDST1

546

P52848
LRLNRSLLWLSLAHN

LRRC71

276

Q8N4P6
RRTLWALALLTSLAA

ASIC4

66

Q96FT7
LARLVHLVESWDLRS

MROH1

1431

Q8NDA8
AQTRHWVIRSLLSIL

HUWE1

3216

Q7Z6Z7
STFNWQHRILLVRAR

ERVK-7

1176

P63135
WLLRLHLKRNADSRT

PLEKHH2

1061

Q8IVE3
ISRHLECLRSREVWL

NCOA4

56

Q13772
HTSNLSWISIRRRQE

OPN4

396

Q9UHM6
ESLRNSARRKWLHQI

EFCAB5

971

A4FU69
TSQEVRIHIRRLLSW

CEMP1

71

Q6PRD7
RSLRAALWRFAELAH

HTT

181

P42858
SLLTSVARRKHRRWQ

DACT2

596

Q5SW24
STFNWQHRILLVRAR

ERVK-25

416

P61570
STFNWQHRILLVRAR

ERVK-6

416

Q69384
HLRRVTWQNLRHLSS

IFNK

36

Q9P0W0
ALRDNRIELVRASWH

CADM2

71

Q8N3J6
HLTITRRRTWSRDEV

CEP170P1

106

Q96L14
WSRLARLQLRHFNEL

ATG9B

481

Q674R7
LLRLLTWELRLAAHS

IFNL4

161

K9M1U5
TLISDRWLLTAAHCR

KLK9

51

Q9UKQ9
DWSTLVPLRLRHRQL

GLB1L2

31

Q8IW92
STFNWQHRILLVRAR

HERVK_113

416

Q902F9
WSLHRKRHLARTLLT

GNRH2

91

O43555
LLRVRWLRLSHNALS

CHADL

181

Q6NUI6
IINHIRILLWDRDSR

BTBD9

331

Q96Q07
LRARWESALDRQLAH

DHX34

946

Q14147
HTQDFLEWRRRLKSL

SEC22C

26

Q9BRL7
SWSLEMLLRRLRAVH

SLC22A14

31

Q9Y267
IWTLLALHQIRAARA

SDK2

6

Q58EX2
AVSVHARSLWRLETL

RYR2

266

Q92736
RLETLRVAWSGSHIR

RYR2

276

Q92736
SSTLRRCRLEAWLQH

DPY19L2P2

361

Q6ZN68
FHRLRLELLLDTWVS

MFNG

66

O00587
TLAWREHLRDGISAR

RTEL1

56

Q9NZ71
RHLSWSDAILRTRFL

RTL9

1261

Q8NET4
RNLTILWLHSNVLAR

RTN4R

81

Q9BZR6
RVLSLSVWHRESLGR

SYTL1

346

Q8IYJ3
LWLSLTFRSARVLSR

TRMT1

6

Q9NXH9
LRLQDDHRNLRKWLT

SYNE2

1946

Q8WXH0
RLLEESLLSLIRNWH

SYNE3

741

Q6ZMZ3
LSEVTAALRERLHRW

STIM1

416

Q13586
SHRVIWLQSVRILSR

RIC8A

61

Q9NPQ8
RNCILHLLSKNWSRR

MTRF1

46

O75570
DAGTLLLSTHRLIWR

VPS36

36

Q86VN1
ASLLSRRWHLQHTLR

TEP1

1641

Q99973
DHLKLFLSRRRWQRS

SPEG

1866

Q15772
SRLEHTWRQLRRSHT

SH2D3A

426

Q9BRG2
TWRQLRRSHTEAALA

SH2D3A

431

Q9BRG2
ARRLWLLLRTSLHEV

WDR97

66

A6NE52
RRLENRRWSSSLLAA

FAM90A2P

396

Q658T7
RALDRHWTSFLKLRL

SEMA6C

271

Q9H3T2
LRRDVQLIRSWSLAT

PLEC

1036

Q15149
RSIHLVTQRLNSQWR

RALGAPB

761

Q86X10
RQSFVDRSLLTLLWH

PRKDC

1816

P78527
SSLTLHRRWHSREKA

ZNF74

261

Q16587
WLVAILTRRHRQAIA

PIEZO1

1021

Q92508
TALLQRDTRARLVLW

PIEZO1

1201

Q92508
RLASGSTDRHIRLWD

WDR12

311

Q9GZL7
TRIEWRHLDAAQRAL

ZNF485

21

Q8NCK3
VLNRASLRERFHSDW

SPATA6

356

Q9NWH7
SALQVLWHLDIFRRS

USP54

46

Q70EL1
LWHLDIFRRSFRQLT

USP54

51

Q70EL1
LRTWFRTRSAIILHL

PLK1

511

P53350