Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	cochlear ganglion hypoplasia	PCDH15 MYO15A HR	2.88e-05	11	80	3	MP:0003637
Domain	DUF4599	SPATA31C2 SPATA31A6 SPATA31C1	2.98e-05	12	98	3	PF15371
Domain	DUF4599	SPATA31C2 SPATA31A6 SPATA31C1	2.98e-05	12	98	3	IPR027970
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.25e-18	12	108	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	8.43e-18	13	108	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.82e-17	8	108	7	17588759
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX1 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.58e-16	17	108	8	11245978
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	2.72e-16	10	108	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.86e-15	13	108	7	7739628
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	1.16e-07	4	108	3	38509386
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	1.16e-07	4	108	3	17911620
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	2.90e-07	5	108	3	20063414
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	CUL4B HECW1 CUL9 UBE2R2 UBA1 CDC34	3.93e-07	90	108	6	35671810
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	1.01e-06	7	108	3	30765463
Pubmed	L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.	CUL4B DTL CDC34	3.44e-06	10	108	3	16861890
Pubmed	Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.	UBA1 NFKBIA CDC34	4.72e-06	11	108	3	24912152
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	LRRIQ3 SREBF1 KDM3B SNX19 CHRNB4 GRAMD1B ESRP2 MYO15A	5.01e-06	303	108	8	25056061
Pubmed	Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8.	DOCK8 IGHM	9.55e-06	2	108	2	38159726
Pubmed	The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme.	UBA1 CDC34	9.55e-06	2	108	2	2842867
Pubmed	The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.	PCDH15 MYO15A	9.55e-06	2	108	2	24940003
Pubmed	Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes.	IGHM HSPA5	9.55e-06	2	108	2	3122216
Pubmed	IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation.	IGHM IL4I1	9.55e-06	2	108	2	29288206
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	9.55e-06	2	108	2	24145033
Pubmed	A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31.	KDM3B HR	9.55e-06	2	108	2	11687974
Pubmed	Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.	IGHM HSPA5	9.55e-06	2	108	2	19808260
Pubmed	Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model.	ATP7B HR	9.55e-06	2	108	2	22308360
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	1.29e-05	15	108	3	35727972
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	1.29e-05	15	108	3	30071041
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	CUL4B HECW1 DTL PARP14 CDC5L HSPA5 UTP14C	1.37e-05	250	108	7	33536335
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LARGE2 VMP1 ATRN ITGA11 SREBF1 KIAA2013 GRAMD1B UBA1 MICAL2 PAM ATP2A3 AGRN HSPA5 MSLN	2.16e-05	1201	108	14	35696571
Pubmed	Plakins: a family of versatile cytolinker proteins.	EPPK1 PPL	2.86e-05	3	108	2	11854008
Pubmed	Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.	PCDH15 MYO15A	2.86e-05	3	108	2	29692870
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPPK1 POLE SREBF1 KDM3B CUL9 AHDC1 KIAA2013 TBC1D16 ESRP2 ARHGEF40 ATP2A3 AGRN HR	3.96e-05	1105	108	13	35748872
Pubmed	IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin.	CCL19 MSLN	5.71e-05	4	108	2	34325726
Pubmed	Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis.	OTUD3 HSPA5	5.71e-05	4	108	2	37107185
Pubmed	Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.	IGHM HSPA5	5.71e-05	4	108	2	14607830
Pubmed	A context-dependent and disordered ubiquitin-binding motif.	UBE2R2 CDC34	5.71e-05	4	108	2	35974206
Pubmed	CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.	CUL4B DTL	5.71e-05	4	108	2	24962565
Pubmed	Control of stereocilia length during development of hair bundles.	PCDH15 MYO15A	5.71e-05	4	108	2	37011103
Pubmed	Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.	DUX1 DUX4L6	5.71e-05	4	108	2	9736770
Pubmed	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.	PCDH15 MYO15A	5.71e-05	4	108	2	30275467
Pubmed	Intracellular trafficking and dynamics of double homeodomain proteins.	DUX4 DUX1	5.71e-05	4	108	2	15709750
Pubmed	MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob Gene and Additional Loci.	HLA-DOA IGHM	5.71e-05	4	108	2	34135064
Pubmed	DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.	DUX4L9 DUX4	5.71e-05	4	108	2	19829708
Pubmed	Synaptic transmission is impaired at neuronal autonomic synapses in agrin-null mice.	CHRNB4 AGRN	5.71e-05	4	108	2	17443806
Pubmed	Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB.	NFKBIA CDC34	5.71e-05	4	108	2	21617130
Pubmed	Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains.	NFKBIA CDC34	5.71e-05	4	108	2	17698585
Pubmed	Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.	UBE2R2 UBA1 CDC34	6.37e-05	25	108	3	17597759
Pubmed	Structural and functional consequences of NEDD8 phosphorylation.	CUL4B UBE2R2 UBA1 CDC34	6.89e-05	70	108	4	34642328
Pubmed	Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.	UBE2R2 UBA1 CDC34	8.07e-05	27	108	3	30097011
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	LARGE2 CUL9 SPTBN5 UBE2R2 SDK1	8.41e-05	142	108	5	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	LARGE2 CUL9 SPTBN5 UBE2R2 SDK1	8.69e-05	143	108	5	20198315
Pubmed	Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.	UBE2R2 CDC34	9.50e-05	5	108	2	27044868
Pubmed	Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.	OTUD3 HSPA5	9.50e-05	5	108	2	32483383
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	9.50e-05	5	108	2	19359275
Pubmed	An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation.	NFKBIA CNTN2	9.50e-05	5	108	2	16611882
Pubmed	Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.	SREBF1 CDC34	9.50e-05	5	108	2	16825193
Pubmed	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.	NFKBIA CDC34	9.50e-05	5	108	2	10329681
Pubmed	Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.	CUL4B CDC34	9.50e-05	5	108	2	16322693
Pubmed	Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.	AGRN HSPA5	9.50e-05	5	108	2	15899857
Pubmed	Periplakin interactions with lens intermediate and beaded filaments.	PPL CNTN2	9.50e-05	5	108	2	19029034
Pubmed	Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain.	IGHM HSPA5	9.50e-05	5	108	2	18584871
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	CUL4B HECW1 UBE2R2 UBA1	1.10e-04	79	108	4	27325702
Pubmed	Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide.	NFKBIA CDC34	1.42e-04	6	108	2	19933270
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A6 SPATA31C1	1.42e-04	6	108	2	20850414
Pubmed	RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.	UBA1 NFKBIA	1.42e-04	6	108	2	17956732
Pubmed	Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.	CUL4B CDC34	1.42e-04	6	108	2	14578910
Pubmed	Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration.	CYP2C19 PYGM	1.42e-04	6	108	2	7749225
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A6 SPATA31C1	1.42e-04	6	108	2	25930072
Pubmed	CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.	CUL4B DTL	1.42e-04	6	108	2	20932471
Pubmed	Characterization of COMMD protein-protein interactions in NF-kappaB signalling.	ATP7B NFKBIA	1.42e-04	6	108	2	16573520
Pubmed	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	UBE2R2 UBA1 CDC34 HSPA5	1.68e-04	88	108	4	27182664
Pubmed	Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse.	PCDH15 MYO15A	1.99e-04	7	108	2	16962269
Pubmed	The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination.	NFKBIA CDC34	1.99e-04	7	108	2	20353940
Pubmed	Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.	IGHM HSPA5	1.99e-04	7	108	2	30819965
Pubmed	Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.	CUL4B DTL	1.99e-04	7	108	2	23555860
Pubmed	Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.	NFKBIA CDC34	1.99e-04	7	108	2	20347421
Pubmed	Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.	PCDH15 MYO15A	1.99e-04	7	108	2	21436032
Pubmed	Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.	VIL1 SMARCD1	1.99e-04	7	108	2	19371634
Pubmed	Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.	PCDH15 MYO15A	2.64e-04	8	108	2	35044843
Pubmed	mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.	CUL4B DTL	2.64e-04	8	108	2	18235224
Pubmed	Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail.	NFKBIA CDC34	2.64e-04	8	108	2	18723677
Pubmed	Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.	DTL CDC34	2.64e-04	8	108	2	23478441
Pubmed	CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.	UBE2R2 CDC34	2.64e-04	8	108	2	12037680
Pubmed	Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.	NFKBIA CDC34	2.64e-04	8	108	2	20638939
Pubmed	Mapping the mouse dactylaplasia mutation, Dac, and a gene that controls its expression, mdac.	CYP2C19 PYGM	2.64e-04	8	108	2	8666395
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN PPL PHLPP1 AQR	3.30e-04	105	108	4	9628581
Pubmed	PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.	CUL4B DTL	3.39e-04	9	108	2	18794347
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	PCDH15 MYO15A	3.39e-04	9	108	2	23144817
Pubmed	LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.	RBCK1 NFKBIA	3.39e-04	9	108	2	21811235
Pubmed	Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.	NFKBIA CDC34	3.39e-04	9	108	2	10713156
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	PCDH15 MYO15A	3.39e-04	9	108	2	19339464
Pubmed	Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins.	CYP2C19 SREBF1	4.23e-04	10	108	2	20235787
Pubmed	Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.	IGHM CCL19	4.23e-04	10	108	2	29186687
Pubmed	Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.	UBA1 NFKBIA	4.23e-04	10	108	2	32246052
Pubmed	Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.	UBE2R2 CDC34	4.23e-04	10	108	2	31868589
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EXOSC10 EPPK1 DOCK8 POLE ERAL1 CDC5L HSPA5 AQR	4.77e-04	582	108	8	20467437
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	VIL1 ATRN TBC1D2 SH2D2A AMER3 PARP14 CHRNB4 ESRP2 HSPA5	4.92e-04	736	108	9	29676528
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	DUX4L9 DUX4L2 DUX4L4	5.13e-04	50	108	3	31806660
Pubmed	Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.	CUL4B CUL9	5.16e-04	11	108	2	31570706
Pubmed	Suramin inhibits cullin-RING E3 ubiquitin ligases.	NFKBIA CDC34	5.16e-04	11	108	2	27001857
Pubmed	Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.	CUL4B CDC34	5.16e-04	11	108	2	22334663
Pubmed	EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.	RBCK1 NFKBIA	5.16e-04	11	108	2	23732909
Interaction	UBE2G1 interactions	CUL9 RBCK1 UBE2R2 UBA1 CDC34	1.77e-06	41	100	5	int:UBE2G1
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.96e-11	27	107	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.69e-10	117	107	8	chr4q35
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	9.56e-08	92	74	7	521
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 PPL	4.55e-04	8	74	2	939
GeneFamily	Cullins	CUL4B CUL9	4.55e-04	8	74	2	1032
ToppCell	droplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD15 ZWILCH LRRIQ3 HLA-DOA POLE DTL PIF1	1.40e-07	173	101	7	2eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN HECW1 HMCN1 PCDH15 MYO15A SDK1 CNTN2	2.12e-07	184	101	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN HECW1 HMCN1 PCDH15 MYO15A SDK1 CNTN2	2.12e-07	184	101	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN HECW1 HMCN1 PCDH15 MYO15A SDK1 CNTN2	2.12e-07	184	101	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZWILCH HLA-DOA GRAMD1B ARHGEF40 IL4I1 CNTN2	2.34e-06	168	101	6	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABHD15 ZWILCH LRRIQ3 POLE DTL PIF1	2.97e-06	175	101	6	73f25bd54309aed1480ddc44bdab518b17e71f92
ToppCell	wk_20-22-Epithelial-Distal_epithelial-type_I_pneumocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TBC1D2 FREM3 PPL ESRP2 AGRN MSLN	5.69e-06	196	101	6	e24a7aaf41793abba66c1189d933ca05b14c1af9
ToppCell	wk_15-18-Epithelial-Distal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	VIL1 LARGE2 PPL ESRP2 AGRN MSLN	5.86e-06	197	101	6	b7aff83c27606d87565382a768119a863fe1c294
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib-Inhibitory_Neuron.Gad1Gad2.Nfib-Satb1_(Supramammillary_Nucleus_(SuM))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RBP3 SH2D2A PPL SPTBN5	1.55e-05	66	101	4	f7d1d272ae723d8100b8c252b3d894dae5297fe4
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RBP3 SH2D2A PPL SPTBN5	1.55e-05	66	101	4	2180e189dad1347ad77733ea95a934d70be97ee4
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib-Inhibitory_Neuron.Gad1Gad2.Nfib-Satb1_(Supramammillary_Nucleus_(SuM))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RBP3 SH2D2A PPL SPTBN5	1.55e-05	66	101	4	412c95c708344fd1726351389bb8a3d376f54fe4
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZWILCH ITGA11 HECW1 GNB1L DTL	3.12e-05	159	101	5	7ed659163f45e0c4df4782997c0786900c8186c8
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LARGE2 PKD1L1 DTL PGK2	3.32e-05	80	101	4	0d02b242164d27f38f70ed77b106612fc7a3abca
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LARGE2 PKD1L1 DTL PGK2	3.32e-05	80	101	4	313344cf7309bc17ca131b92a91b24489df577e2
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Tmem2_(Tmem2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LARGE2 PKD1L1 DTL PGK2	3.32e-05	80	101	4	b95e4456adb7f7d42825351f010376c10bb35380
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Lgr5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL36A PGK2 SLC5A1	3.45e-05	28	101	3	065da9144b7d8c79a583122288f1e7b5db86a794
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMER3 CFAP65 PAM ATP2A3 UNC13A	4.06e-05	168	101	5	38ba7737ae0afffcbd3aa499403e83c24a922127
ToppCell	FLU-Healthy-3\|FLU / Virus stimulation, Condition and Cluster	LRRIQ3 POLE DTL C1orf53 IL4I1	4.66e-05	173	101	5	32b8e5b400885dbeba57a7cb2c18d882664dc285
ToppCell	FLU-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	LRRIQ3 POLE DTL C1orf53 IL4I1	4.66e-05	173	101	5	26e89ac86922f1cd0100cf4d1cce37e74dd31c88
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	LARGE2 LRRIQ3 DTL CFAP65 OTUD3	4.92e-05	175	101	5	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	LARGE2 LRRIQ3 DTL CFAP65 OTUD3	4.92e-05	175	101	5	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD15 DOCK8 GRAMD1B NFKBIA IL4I1	5.06e-05	176	101	5	238244294d08975df6bfa26b2b437db3654408ae
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HLA-DOA GRAMD1B ARHGEF40 IL4I1 CNTN2	5.20e-05	177	101	5	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD15 DOCK8 GRAMD1B NFKBIA IL4I1	5.48e-05	179	101	5	dd3cf8fd10dc257d933a7f45860dc2e244c158b7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 HECW1 SLC5A1 GRAMD1B CDH9	5.93e-05	182	101	5	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 CUL9 AMER3 ATP2A3 SDK1	6.41e-05	185	101	5	d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FREM3 SLC5A1 MICAL2 AGRN MSLN	6.74e-05	187	101	5	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD56bright_CD16-\|lymph-node_spleen / Manually curated celltypes from each tissue	ABHD15 SH2D2A MICAL2 NFKBIA HSPA5	6.74e-05	187	101	5	9000241566f48e435db9409b7255db68b68f6059
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	AMER3 PPL CFAP65 ATP2A3 UNC13A	6.74e-05	187	101	5	98477ba04a42a8da80a72f41a182429f46283595
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CES5A FREM3 SLC5A1 SLC14A1 ATP2A3	6.91e-05	188	101	5	02b3aae071ff1f469d52a4d513a4eb46ae70bba3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	AMER3 PPL CFAP65 ATP2A3 UNC13A	7.27e-05	190	101	5	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	AMER3 PPL ATP2A3 KCNT1 UNC13A	7.27e-05	190	101	5	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17\|lymph-node_spleen / Manually curated celltypes from each tissue	SH2D2A GRAMD1B NFKBIA IL4I1 HSPA5	8.21e-05	195	101	5	c60982804a74dbe6607c021799ca74af2204aba8
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBC1D2 FREM3 PPL AGRN MSLN	8.21e-05	195	101	5	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	wk_20-22-Epithelial-Distal_epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TBC1D2 PPL ESRP2 AGRN MSLN	8.41e-05	196	101	5	cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells\|LPS_only / Treatment groups by lineage, cell group, cell type	HLA-DOA DOCK8 GRAMD1B IL4I1 CNTN2	8.62e-05	197	101	5	59ddd8ff7dddf3747b988374e1a4d80959db803e
ToppCell	15-Distal-Epithelial-Bud_tip_adjacent\|Distal / Age, Tissue, Lineage and Cell class	EPPK1 TBC1D2 PPL ESRP2 MSLN	8.83e-05	198	101	5	f4d9d5995a42f71bf412f0ad299fc963bad3a898
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBC1D2 PPL ESRP2 AGRN MSLN	8.83e-05	198	101	5	1851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 DOCK8 TBC1D2 CFAP65 ATP2A3	8.83e-05	198	101	5	f95f38cc747fb3549a791288bf8d0518c049ac96
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells-mDC\|LPS_only / Treatment groups by lineage, cell group, cell type	HLA-DOA DOCK8 CCL19 IL4I1 CNTN2	8.83e-05	198	101	5	53c22e81e530d6fc272d4a45c8d1bf125feb254d
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBC1D2 PPL ESRP2 AGRN MSLN	8.83e-05	198	101	5	c477405b093f4e5374e57bcacf1fb204a0f7eb3b
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-goblet\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 DOCK8 TBC1D2 CFAP65 ATP2A3	8.83e-05	198	101	5	9c5d7852f03468394e726c444cac92a043fc6d0e
ToppCell	Biopsy_Control_(H.)-Epithelial-KRT5-/KRT17+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	EPPK1 CAPN6 SPTBN5 AGRN MSLN	9.04e-05	199	101	5	3b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
Disease	amygdala volume change measurement	PKD1L1 SPATA31C2 SPATA31C1	1.93e-05	16	98	3	EFO_0021490
Disease	alcohol use disorder (implicated_via_orthology)	SREBF1 KDM3B SMARCD1 CDC5L UNC13A HR	4.90e-05	195	98	6	DOID:1574 (implicated_via_orthology)
Disease	renal overload-type gout	SPATA31C2 SPATA31C1	1.62e-04	6	98	2	EFO_0021525
Disease	eosinophil cationic protein measurement	SPATA31C2 SPATA31C1	3.02e-04	8	98	2	EFO_0010913
Disease	longitudinal alcohol consumption measurement	SPATA31C2 SPATA31C1	3.87e-04	9	98	2	EFO_0007645
Disease	age at menarche, spine bone mineral density	RUNDC3B PCDH15	4.83e-04	10	98	2	EFO_0004703, EFO_0007701
Disease	prostate adenocarcinoma (is_marker_for)	NFKBIA PAM	4.83e-04	10	98	2	DOID:2526 (is_marker_for)
Disease	egg allergy measurement, parental genotype effect measurement	SPATA31C2 SPATA31C1	8.32e-04	13	98	2	EFO_0005939, EFO_0007018
Disease	glycerate measurement	HMCN1 AGRN	1.11e-03	15	98	2	EFO_0021029
Disease	response to platinum based chemotherapy, magnesium measurement	TBC1D16 PCDH15	1.11e-03	15	98	2	EFO_0004647, EFO_0004845
Disease	diffuse idiopathic skeletal hyperostosis	UQCC1 CDC5L	1.11e-03	15	98	2	EFO_0007236
Disease	PR interval	RUNDC3B CUL9 ARHGEF40 MICAL2 NFKBIA PAM CDC5L	1.33e-03	495	98	7	EFO_0004462
Disease	resting heart rate	EPPK1 SREBF1 ARHGEF40 MICAL2	1.56e-03	149	98	4	EFO_0004351
Disease	alcoholic hepatitis (biomarker_via_orthology)	SREBF1 NFKBIA	1.61e-03	18	98	2	DOID:12351 (biomarker_via_orthology)
Disease	lung cancer (is_implicated_in)	POLE CHRNB4 NFKBIA	1.94e-03	74	98	3	DOID:1324 (is_implicated_in)
Disease	neoplasm of mature B-cells	GRAMD1B PHLPP1	2.00e-03	20	98	2	EFO_0000096
Disease	bipolar disorder, schizophrenia, response to lithium ion	GRAMD1B MAIP1	2.00e-03	20	98	2	GO_0010226, MONDO_0004985, MONDO_0005090
Disease	Cleft palate, cleft lip	GNB1L SPATA31C2 SPATA31C1 KIAA2013 SDK1	2.42e-03	279	98	5	EFO_0003959, HP_0000175
Disease	lung squamous cell carcinoma (is_implicated_in)	POLE CHRNB4	2.87e-03	24	98	2	DOID:3907 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTVWIPLRTIRQSNE	UNC13A	76	Q9UPW8
TNLIVRSNGSVLWLP	CHRNB4	131	P30926
SVRQQQRALLGPWLS	AMER3	316	Q8N944
QWRTIAPIIGRTAAQ	CDC5L	81	Q99459
LRRLQQVLQWLSGPG	ARHGEF40	786	Q8TER5
SVTPVQLARDWQRGI	ANKRD23	276	Q86SG2
PQTFSVLIGNREWLR	ATP7B	1141	P35670
TGLPESRIQIWFQNR	DUX4L4	131	P0CJ87
STVPVNTNRWLRVVA	AGRN	1966	O00468
RNGQWTLIGRQSPQL	PAM	251	P19021
WPTRVRADVTINLNV	AQR	531	O60306
VLRQPQLGVLRNGWS	DTL	6	Q9NZJ0
TGLPESRIQIWFQNR	DUX4L6	131	P0CJ89
WDNGRVNLRPVVQLI	AHDC1	111	Q5TGY3
IFQVTPLSGRQWVVV	ATP2A3	956	Q93084
PLSGRQWVVVLQISL	ATP2A3	961	Q93084
AWQGLRLQERLPQSQ	GRAMD1B	661	Q3KR37
LVIPNAWGRLTRNVL	ABHD15	161	Q6UXT9
QVVAQARLIVWNGPL	PGK2	326	P07205
GLVQRLPCVWNVQLS	LARGE2	306	Q8N3Y3
VTWLQTLPQGRQLLS	GNB1L	71	Q9BYB4
IVLGFSNPINWVRTR	MAIP1	111	Q8WWC4
TGLPESRIQIWFQNR	DUX4	131	Q9UBX2
WLITRVNALVSPRQD	MYO15A	1566	Q9UKN7
RRSKIIGNTVNPIWQ	HECW1	251	Q76N89
PVLQQWVIGQRLARD	RBCK1	96	Q9BYM8
QPWVERIIQRLQRTS	CCL19	76	Q99731
RGLIQPNERLTLTWT	CFAP65	931	Q6ZU64
SREWLPLNRSVNNVV	ATRN	376	O75882
QVRRVLQIPLWSQRV	KCNT1	396	Q5JUK3
TGLPESRIQIWFQNR	DUX4L3	131	P0CJ86
WRQGQPVLVSGIQRT	HR	866	O43593
WTLRNQGPQESVVRK	PPL	921	O60437
PQRNTRLGWIQGKQV	CES5A	31	Q6NT32
LVQSVLRVWQVGPHV	ERAL1	11	O75616
LLQGIRVSIAQWPAL	KDM3B	106	Q7LBC6
LTWGRPSTRIQQQLG	NFKBIA	256	P25963
RSIPQGIVAAWRQRS	MSLN	261	Q13421
IWSRPESTQVQNILR	GGPS1	221	O95749
RTARSILDLPWQIVQ	POLE	1321	Q07864
ALGNAVILWSRPVVQ	ITGA11	626	Q9UKX5
VILWSRPVVQINASL	ITGA11	631	Q9UKX5
PTLRQLWSRGQQVIV	PLCXD1	186	Q9NUJ7
IPETLLSWQRVRVAN	PLBD1	316	Q6P4A8
PVITWLRNGERLQAT	HMCN1	3651	Q96RW7
VIHQLNAPLWQIRGT	OTUD3	151	Q5T2D3
TLVNEGRPRIKTWQA	PARP14	371	Q460N5
RPEIIDLQQWQGTRQ	PCDH15	1591	Q96QU1
GQPVQLQVVWQRSRD	EXOSC10	461	Q01780
RVWVLQDQTLIAVPR	IL36A	21	Q9UHA7
LNENIRIVSTPWIQI	CYP2C19	201	P33261
PVINITWLRNGQTVT	HLA-DOA	141	P06340
IREWLIVNRKNQGSP	DOCK8	126	Q8NF50
PRQIQVSWLREGKQV	IGHM	141	P01871
TGLPESRIQIWFQNR	DUX4L9	131	Q6RFH8
PLWVRAGFRQQLSLT	C1orf53	26	Q5VUE5
TVQGRIIVQAQPEWL	CNTN2	316	Q02246
TGLPESRIQIWFQNR	DUX4L7	131	P0CJ90
TGLPESRIQIWFQNR	DUX1	131	O43812
TIVTTPRRQGWVFRQ	CUL9	351	Q8IWT3
WPIIQIRIKRCQQGG	CUL9	1271	Q8IWT3
TGLPESRIQIWFQNR	DUX4L5	131	P0CJ88
KRLIGRTWNDPSVQQ	HSPA5	96	P11021
RRTTDIPIIVQVWNS	CAPN6	571	Q9Y6Q1
PQAEVTARSLRLQWV	SDK1	1486	Q7Z5N4
TIFQIRRTVPLWENI	CDH9	696	Q9ULB4
KVQIWRSQPVRLGVT	PKD1L1	686	Q8TDX9
IGIIVVIWRQPQSST	SLC7A3	521	Q8WY07
SRVRGGVQVLLQQWI	CUL4B	481	Q13620
PRAQALSGVLWRLQQ	MICAL2	831	O94851
WGLNRTLKPQRVIVV	IL4I1	51	Q96RQ9
QFNPGQTTATWRVRI	FREM3	1831	P0C091
RWLAHLQIPLQGQVT	RUNDC3B	86	Q96NL0
PGVRQGWLNCQRLVI	PIF1	291	Q9H611
RAVLQLPGLTQVRWS	MRPS7	21	Q9Y2R9
QTNEGLIPVSVRRSW	SPATA31C2	586	B4DYI2
LIPVSVRRSWLAVNQ	SPATA31C2	591	B4DYI2
SRQVLQDRGQAWLPL	SH2D2A	371	Q9NP31
GIHTQTRPVIIQALW	SMARCD1	306	Q96GM5
LIPVRVRRSWLAVNQ	SPATA31A6	741	Q5VVP1
VRRSWLAVNQALPVS	SPATA31A6	746	Q5VVP1
VARLLQPSVIWIGNA	IQCA1L	616	A6NCM1
TVPQLLASVQRWVQE	EPPK1	1171	P58107
VGVLRIWNVSRTTPI	WDR17	291	Q8IZU2
QLVPNWTSRGRQLRQ	SLF2	1001	Q8IX21
VWQVVEPRSRQVGTL	ESRP2	56	Q9H6T0
GLIPVSVRRSWLAVN	SPATA31C1	596	P0DKV0
VTVRWQRLLQHLQGQ	SPTBN5	511	Q9NRC6
LLLVVRTSLWRQQQP	SREBF1	976	P36956
SLNITTPGLQIWRIE	VIL1	11	P09327
TLIIQSLQRGDIQPW	ZWILCH	371	Q9H900
RTIQTPIGSTWNTQR	UTP14C	696	Q5TAP6
SERWNPTQNVRTILL	CDC34	111	P49427
GPQLVRLVWQQLVDT	RBP3	761	P10745
QNKTNGITPRRWLVL	PYGM	481	P11217
TLILAWVPNSRIQRQ	TBC1D16	76	Q8TBP0
LTWLQSLRGVPHVIQ	TEX10	696	Q9NXF1
WVRRLSTPAGVQVIL	MRPL34	66	Q9BQ48
RVLRNQTSISQWVPV	UQCC1	6	Q9NVA1
WILRGISQVVFVNNP	SLC14A1	61	Q13336
VQRWLEVQVANLTSP	SNX19	856	Q92543
VQRSLVLQRPQTWAD	UBA1	691	P22314
QLPVNRWTRRQVILC	PHLPP1	551	O60346
SERWNPTQNVRTILL	UBE2R2	111	Q712K3
WRTVLNVNGIILVTV	SLC5A1	641	P13866
LQRSVQRLPAGWTRV	WDR81	91	Q562E7
RRVLLAFSWQNPTIG	TBC1D2	696	Q9BYX2
VQRWQVNPTVGKSRQ	ZKSCAN5	306	Q9Y2L8
VALPVWLAQGRVTIR	ZAN	1626	Q9Y493
RQNIVLWRQPLITLQ	VMP1	41	Q96GC9
TGLPESRIQIWFQNR	DUX4L2	131	P0CJ85
NLWPGRLSSVQQILQ	KIAA2013	411	Q8IYS2
NSPVLIVQRWIRGFL	LRRIQ3	216	A6PVS8