Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TNF	TNFSF13 TNFSF15	1.00e-03	18	49	2	SM00207
Domain	TNF	TNFSF13 TNFSF15	1.12e-03	19	49	2	PF00229
Domain	TNF_dom	TNFSF13 TNFSF15	1.12e-03	19	49	2	IPR006052
Domain	TNF_2	TNFSF13 TNFSF15	1.12e-03	19	49	2	PS50049
Domain	Cys-rich_flank_reg_C	PXDNL SLIT3 LINGO4	1.70e-03	90	49	3	IPR000483
Domain	LRRCT	PXDNL SLIT3 LINGO4	1.70e-03	90	49	3	SM00082
Domain	-	TEPSIN CHERP	2.11e-03	26	49	2	1.25.40.90
Domain	LRRNT	PXDNL SLIT3 LINGO4	2.17e-03	98	49	3	IPR000372
Domain	LRRNT	PXDNL SLIT3 LINGO4	2.17e-03	98	49	3	SM00013
Domain	Calcineurin-like_PHP_ApaH	NT5E SMPD1	2.44e-03	28	49	2	IPR004843
Domain	Metallophos	NT5E SMPD1	2.44e-03	28	49	2	PF00149
Domain	ENTH_VHS	TEPSIN CHERP	2.62e-03	29	49	2	IPR008942
Domain	Metallo-depent_PP-like	NT5E SMPD1	2.80e-03	30	49	2	IPR029052
Domain	-	NT5E SMPD1	2.80e-03	30	49	2	3.60.21.10
Domain	Kinesin_motor_CS	STARD9 KIF19	5.18e-03	41	49	2	IPR019821
Domain	KINESIN_MOTOR_1	STARD9 KIF19	5.95e-03	44	49	2	PS00411
Domain	-	STARD9 KIF19	5.95e-03	44	49	2	3.40.850.10
Domain	Kinesin_motor_dom	STARD9 KIF19	5.95e-03	44	49	2	IPR001752
Domain	Kinesin	STARD9 KIF19	5.95e-03	44	49	2	PF00225
Domain	KINESIN_MOTOR_2	STARD9 KIF19	5.95e-03	44	49	2	PS50067
Domain	KISc	STARD9 KIF19	5.95e-03	44	49	2	SM00129
Domain	Znf_FYVE_PHD	MTMR4 BAZ2A BSN	6.75e-03	147	49	3	IPR011011
Domain	-	TNFSF13 TNFSF15	7.62e-03	50	49	2	2.60.120.40
Domain	WD40_repeat_CS	SCAP POC1A CDC40	9.11e-03	164	49	3	IPR019775
Domain	Tumour_necrosis_fac-like_dom	TNFSF13 TNFSF15	1.02e-02	58	49	2	IPR008983
Domain	LRR_8	PXDNL SLIT3 LINGO4	1.02e-02	171	49	3	PF13855
Pubmed	A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.	CDKN1B UHMK1	2.03e-06	2	50	2	12093740
Pubmed	KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.	CDKN1B UHMK1	6.07e-06	3	50	2	19033656
Pubmed	ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation.	CDKN1B TNK2	6.07e-06	3	50	2	35247157
Pubmed	Nonylphenol regulates TL1A through the AhR/HDAC2/HNF4α pathway in endothelial cells to promote the angiogenesis of colorectal cancer.	HNF4A TNFSF15	6.07e-06	3	50	2	34974051
Pubmed	Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.	CDKN1B NT5E RAD9A	6.96e-05	55	50	3	19536092
Pubmed	Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program.	SOX1 CDKN1B	7.25e-05	9	50	2	29530878
Pubmed	Mutation discovery in mice by whole exome sequencing.	PFAS SAMD4A	7.25e-05	9	50	2	21917142
Pubmed	Genomic analysis of mouse retinal development.	CDKN1B FZD9 MTMR4 ANKRD33 TNFSF13 BAZ2A SLIT3 BSN	8.71e-05	1006	50	8	15226823
Pubmed	Prox1 function is crucial for mouse lens-fibre elongation.	SOX1 CDKN1B	2.10e-04	15	50	2	10080188
Pubmed	Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.	NT5E HNF4A	2.40e-04	16	50	2	27125672
Pubmed	Characterization of the development of the mouse cochlear epithelium at the single cell level.	CDKN1B FZD9	2.40e-04	16	50	2	32404924
Pubmed	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	BSN HNF4A	2.72e-04	17	50	2	19915572
Pubmed	Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.	SOX1 CDKN1B	2.72e-04	17	50	2	18455718
Pubmed	Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.	CDKN1B PLXNA3	3.05e-04	18	50	2	26302206
Pubmed	Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.	TNFSF13 TNFSF15	3.05e-04	18	50	2	26646413
Pubmed	Transcription factor GATA-3 is essential for lens development.	SOX1 CDKN1B	3.05e-04	18	50	2	19623612
Pubmed	p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration.	CDKN1B GSN	3.05e-04	18	50	2	23022035
Pubmed	Compensation by tumor suppressor genes during retinal development in mice and humans.	CDKN1B BSN	3.41e-04	19	50	2	16672052
Pubmed	Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.	CDKN1B GSN	3.41e-04	19	50	2	21118511
Pubmed	Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.	SOX1 CDKN1B	3.79e-04	20	50	2	19542352
Pubmed	Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.	HNF4A GSN	4.18e-04	21	50	2	19015235
Pubmed	Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.	SOX1 CDKN1B	4.18e-04	21	50	2	12072567
Pubmed	Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.	CHERP UHMK1	4.59e-04	22	50	2	26420826
Pubmed	FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.	HGH1 SMPD1	5.03e-04	23	50	2	26124079
Pubmed	PRDM16 expression and function in mammalian cochlear development.	CDKN1B GSN	5.03e-04	23	50	2	35451126
Pubmed	Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.	SOX1 CDKN1B	5.95e-04	25	50	2	25664857
Pubmed	Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.	SOX1 CDKN1B	6.44e-04	26	50	2	28082864
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	PLXNA3 SLIT3	7.48e-04	28	50	2	18617019
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	BSN TNFSF15	7.48e-04	28	50	2	19422935
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TBRG4 CHERP ERP44 CDC40 STARD9 PFAS CPOX BSN	9.03e-04	1425	50	8	30948266
Pubmed	The synaptic vesicle cycle.	UNC13C BSN	9.17e-04	31	50	2	15217342
Pubmed	Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.	CDKN1B HNF4A	9.77e-04	32	50	2	27292642
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	SOX1 CDKN1B	9.77e-04	32	50	2	19286674
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	SOX1 CDKN1B	1.10e-03	34	50	2	18539113
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	TNFSF13 ZPLD1 PXDNL CD163L1 APC2 TNFSF15	1.14e-03	824	50	6	20237496
Pubmed	A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.	CDKN1B FZD9	1.24e-03	36	50	2	15800025
Pubmed	Axon guidance genes control hepatic artery development.	SLIT3 HNF4A	1.24e-03	36	50	2	37497580
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	STARD9 KIF19	1.31e-03	37	50	2	11416179
Pubmed	Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.	SOX1 CDKN1B	1.31e-03	37	50	2	27631609
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	TEPSIN KIF19 GALR2	4.60e-03	307	50	3	chr17q25
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	SCAP POC1A BSN	4.99e-03	316	50	3	chr3p21
Cytoband	3p21.31	SCAP BSN	5.38e-03	100	50	2	3p21.31
Cytoband	17q25.3	TEPSIN GALR2	5.48e-03	101	50	2	17q25.3
GeneFamily	CD molecules\|Endogenous ligands\|Tumor necrosis factor superfamily\|Death inducing signaling complex	TNFSF13 TNFSF15	5.46e-04	18	35	2	781
Coexpression	GSE12003_MIR223_KO_VS_WT_BM_PROGENITOR_8D_CULTURE_DN	CDKN1B POC1A HECTD3 CD163L1 SMPD1	8.67e-06	146	50	5	M392
Coexpression	GSE10240_IL17_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN	SCAP HGH1 APC2 SLIT3 HNF4A	3.85e-05	199	50	5	M312
Coexpression	NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	TEPSIN MTMR4 INTS2 TTLL6 KIF19 GALR2	4.06e-05	334	50	6	M15936
ToppCell	COVID-CD8-exh_CD4\|COVID / Condition, Cell_class and T cell subcluster	TEPSIN CHERP SMPD1 RAD9A	3.61e-05	166	50	4	4ca8c91b03d08489f244898cf9423b9d10348bc8
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	CHERP C19orf44 PFAS GALR2	3.69e-05	167	50	4	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	droplet-Lung-nan-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5E CD163L1 LINGO4 UNC13C	4.84e-05	179	50	4	8ebd0c7ac99ac8194fa1a2aac88a893739a97725
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5E CD163L1 LINGO4 UNC13C	4.94e-05	180	50	4	81c7086399256260e59424b7410feec514ce8027
ToppCell	Mesenchymal_cells-Stromal_fibro.\|Mesenchymal_cells / Lineage and Cell class	NT5E UNC13C TNFSF15 GSN	5.05e-05	181	50	4	f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5E CD163L1 LINGO4 UNC13C	5.05e-05	181	50	4	eaa3a2c268cce527004ae656d35e037b984fb4c7
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5E CD163L1 LINGO4 UNC13C	5.05e-05	181	50	4	c7ad10a696d94b9ee91cd7e62761d356d5106eda
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5E CD163L1 LINGO4 TNK2	5.27e-05	183	50	4	302bd0f1f8025f385a764f2a9adafdd7f1f67ea3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX1 LINGO4 UNC13C GPRIN2	6.48e-05	193	50	4	64a37dae3d631713b06d94691f5dcdb200dfef5e
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|Mesenchymal_cells / Lineage and Cell class	FZD9 NT5E C10orf105 GALR2	6.74e-05	195	50	4	b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FZD9 NT5E C10orf105 GSN	6.74e-05	195	50	4	d00cb2fab25f2026a9668a7f0686938a2e7155e2
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|World / Lineage and Cell class	FZD9 NT5E C10orf105 GALR2	6.88e-05	196	50	4	ddc168849e0e97005a111be004463bb72d433853
ToppCell	(2)_Fibroblasts-(23)_Fibro-4\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	NT5E C10orf105 GALR2 GSN	7.01e-05	197	50	4	a183919023a4aca90a06be0e5e89c817b38c5574
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	NT5E C10orf105 GALR2 GSN	7.15e-05	198	50	4	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FZD9 SLIT3 GSN SAMD4A	7.29e-05	199	50	4	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	FZD9 TNK2 KDM8 SAMD4A	7.44e-05	200	50	4	401d50fa394fa863fa7836344110ae5c7af3250a
Drug	Propoxycaine hydrochloride [550-83-4]; Down 200; 12uM; MCF7; HT_HG-U133A	PLXNA3 BAZ2A NT5E ANKMY1 KDM8 SAMD4A	3.76e-06	195	49	6	6803_DN
Disease	indole-3-propionate measurement	SLIT3 UNC13C	9.23e-04	27	49	2	EFO_0010501
Disease	interleukin 5 measurement	TTLL6 SAMD4A	9.93e-04	28	49	2	EFO_0008185
Disease	serum IgA measurement	TNFSF13 TNFSF15	1.22e-03	31	49	2	EFO_0004912
Disease	Inflammatory Bowel Diseases	APC2 TNFSF15	1.55e-03	35	49	2	C0021390
Disease	hepatocyte growth factor-like protein measurement	POC1A BSN	1.83e-03	38	49	2	EFO_0008154
Disease	thioredoxin domain-containing protein 12 measurement	SCAP BSN	1.92e-03	39	49	2	EFO_0008298
Disease	Mesothelioma	CDKN1B GSN	2.13e-03	41	49	2	C0025500
Disease	creatine kinase measurement	CD163L1 SAMD4A	4.35e-03	59	49	2	EFO_0004534
Disease	Ulcerative Colitis	HNF4A TNFSF15	4.95e-03	63	49	2	C0009324
Disease	hematocrit	ANKRD33 LINGO4 PFAS BSN HNF4A GSN	6.35e-03	1011	49	6	EFO_0004348

Protein segments in the cluster

Peptide	Gene	Start	Entry
EMLPEHGSCRPKARS	TNFSF15	16	O95150
ARADSPALCRHLMPD	SMPD1	601	P17405
DMCLTDHQPLPDFSR	BAZ2A	826	Q9UIF9
AHRQPRLVGADMPCS	CD163L1	791	Q9NR16
MDARQAEHPKPSACR	CDKN1B	16	P46527
ALRPCAPSLAQLAMD	TNK2	581	Q07912
LHRRRLDMSEALPCP	ANKRD33	71	Q7Z3H0
FDPASCPHMLRAPAR	RAD9A	136	Q99638
CPHMLRAPARVLGEA	RAD9A	141	Q99638
MAAPCAEDPSLERHF	POC1A	1	Q8NBT0
MAGDTHCPAEPLARE	KDM8	1	Q8N371
RHSMPRLRDACELES	BSN	2556	Q9UPA5
VPRHCPELAEMSRVS	HNF4A	251	P41235
PSMRVCAHRLAPVDN	PLXNA3	81	P51805
LRCDQRVHRCPPLMD	INTS2	861	Q9H0H0
IGAADPHMLENLRRC	MSLNL	191	Q96KJ4
MAAAPPLRDRLSFLH	TEPSIN	1	Q96N21
LQMRLDIRHCCAPPA	MTMR4	1046	Q9NYA4
AERISDHRMPVCRHP	KIF19	916	Q2TAC6
DPRGTHAPCMLFARS	PXDNL	851	A1KZ92
RLPTRNDPHALCMEA	FZD9	141	O00144
DLLHMSEAAGALRPC	GALR2	341	O43603
HMLPCPLAALASRRE	APC2	941	O95996
SPPHCELMAGHLRNR	CHERP	186	Q8IWX8
IRCHRPAPLTMEDAL	C19orf44	636	Q9H6X5
ARCPFHTLMPAERET	ANKMY1	796	Q9P2S6
MHPAVFLSLPDLRCS	ERP44	1	Q9BS26
MAPHRPAPALLCALS	GSN	1	P06396
CHALPPAALLCGMRE	GPRIN2	226	O60269
LELCDPPHRLAFSMG	SLC22A31	206	A6NKX4
MLLHPSPNCSLRAES	SCAP	256	Q12770
DELAHRCSSFMAPPV	CPOX	121	P36551
CLLREAARQAPAMAP	TBRG4	11	Q969Z0
RLRRHLDFGMSPPAC	LINGO4	371	Q6UY18
LSREPAPCAALMAAL	HGH1	131	Q9BTY7
SSRCPLPAADSLMHL	CDC40	26	O60508
PRLLEPSDHASMCLA	STARD9	2536	Q9P2P6
HSRAPCPGDLREMIS	SOX1	331	O00570
MCPRAARAPATLLLA	NT5E	1	P21589
PAALDPSRRRAHECM	C10orf105	61	Q8TEF2
IARCSSPEPMADRLL	SLIT3	881	O75094
FLSDRHRCEMPSPEL	USP27X	106	A6NNY8
CPFLMPICSHRERRD	ZPLD1	306	Q8TCW7
ECPNPEALSHLMRRF	UNC13C	1751	Q8NB66
SCDGRHLAVMPHPER	PFAS	1286	O15067
SRQCRALLEMGHPDS	SPTBN4	1681	Q9H254
LDPRPCRSHASAMRD	TTLL6	806	Q8N841
HDDPSRRIPAEMALC	UHMK1	286	Q8TAS1
MSHEDLRARGPQCLP	SAMD4A	271	Q9UPU9
ETLFRCIRSMPSHPD	TNFSF13	191	O75888
AMEHRACPSRDPACK	HECTD3	481	Q5T447