Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

RANBP10 VAV3 VAV1 VAV2 SOS1 SOS2

1.24e-04231676GO:0005085
GeneOntologyMolecularFunctionPOU domain binding

POU5F1 POU5F1B

2.30e-047672GO:0070974
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RANBP10 ARAP3 TBC1D14 VAV3 VAV1 VAV2 SOS1 SOS2

2.86e-04507678GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RANBP10 ARAP3 TBC1D14 VAV3 VAV1 VAV2 SOS1 SOS2

2.86e-04507678GO:0030695
GeneOntologyMolecularFunctionepidermal growth factor receptor binding

VAV3 VAV2 SOS1

3.51e-0441673GO:0005154
GeneOntologyMolecularFunctionphosphotyrosine residue binding

MAPK3 VAV1 VAV2

6.70e-0451673GO:0001784
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

CYBB NOX3

7.16e-0412672GO:0016175
GeneOntologyMolecularFunctionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

POU5F1 POU5F1B

8.45e-0413672GO:0001162
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN4 PEX5L

8.45e-0413672GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN4 PEX5L

8.45e-0413672GO:0043855
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1E2 AKR1C4

9.83e-0414672GO:0004032
GeneOntologyMolecularFunctioncaspase binding

NLRP7 NLRC4

1.29e-0316672GO:0089720
GeneOntologyMolecularFunctionintronic transcription regulatory region sequence-specific DNA binding

POU5F1 POU5F1B

1.46e-0317672GO:0001161
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

MAPK3 VAV1 VAV2

1.61e-0369673GO:0045309
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

CYBB NOX3

2.03e-0320672GO:0050664
GeneOntologyMolecularFunctionHMG box domain binding

POU5F1 POU5F1B

2.68e-0323672GO:0071837
GeneOntologyBiologicalProcessFc-epsilon receptor signaling pathway

VAV3 VAV1 VAV2 SOS1

1.08e-0625654GO:0038095
GeneOntologyBiologicalProcesssynaptic membrane adhesion

PTPRS LRRC4B SLITRK3 SLITRK1

9.19e-0642654GO:0099560
GeneOntologyBiologicalProcesstrophectodermal cell fate commitment

POU5F1 POU5F1B

2.93e-053652GO:0001830
GeneOntologyBiologicalProcesspresynapse assembly

PTPRS LRRC4B SLITRK3 SLITRK1

3.84e-0560654GO:0099054
GeneOntologyBiologicalProcessFc receptor signaling pathway

VAV3 VAV1 VAV2 SOS1

4.37e-0562654GO:0038093
GeneOntologyBiologicalProcessimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis

VAV3 VAV1 VAV2

6.54e-0525653GO:0002433
GeneOntologyBiologicalProcessFc-gamma receptor signaling pathway involved in phagocytosis

VAV3 VAV1 VAV2

6.54e-0525653GO:0038096
GeneOntologyBiologicalProcesspresynapse organization

PTPRS LRRC4B SLITRK3 SLITRK1

8.30e-0573654GO:0099172
GeneOntologyBiologicalProcessectodermal cell fate commitment

POU5F1 POU5F1B

9.72e-055652GO:0001712
GeneOntologyBiologicalProcesspostsynaptic density assembly

PTPRS LRRC4B SLITRK3

1.67e-0434653GO:0097107
GeneOntologyBiologicalProcessFc receptor mediated stimulatory signaling pathway

VAV3 VAV1 VAV2

1.82e-0435653GO:0002431
GeneOntologyBiologicalProcessectoderm formation

POU5F1 POU5F1B

2.03e-047652GO:0001705
GeneOntologyBiologicalProcessFc-gamma receptor signaling pathway

VAV3 VAV1 VAV2

2.52e-0439653GO:0038094
GeneOntologyBiologicalProcessregulation of pro-B cell differentiation

SOS1 SOS2

2.70e-048652GO:2000973
GeneOntologyBiologicalProcessregulation of presynapse assembly

LRRC4B SLITRK3 SLITRK1

3.14e-0442653GO:1905606
GeneOntologyBiologicalProcessectodermal cell differentiation

POU5F1 POU5F1B

3.47e-049652GO:0010668
GeneOntologyBiologicalProcesspostsynaptic specialization assembly

PTPRS LRRC4B SLITRK3

3.61e-0444653GO:0098698
GeneOntologyBiologicalProcessregulation of presynapse organization

LRRC4B SLITRK3 SLITRK1

4.12e-0446653GO:0099174
GeneOntologyBiologicalProcessexcitatory synapse assembly

PTPRS LRRC4B SLITRK3

4.12e-0446653GO:1904861
GeneOntologyBiologicalProcessgerm-line stem cell population maintenance

POU5F1 POU5F1B

4.33e-0410652GO:0030718
GeneOntologyBiologicalProcessendodermal cell fate specification

POU5F1 POU5F1B

5.28e-0411652GO:0001714
GeneOntologyBiologicalProcessnegative regulation of calcium ion-dependent exocytosis

POU5F1 POU5F1B

5.28e-0411652GO:0045955
GeneOntologyBiologicalProcessregulation of lymphoid progenitor cell differentiation

SOS1 SOS2

6.32e-0412652GO:1905456
GeneOntologyBiologicalProcesspro-B cell differentiation

SOS1 SOS2

7.46e-0413652GO:0002328
GeneOntologyBiologicalProcessERBB2-ERBB3 signaling pathway

MAPK3 SOS1

7.46e-0413652GO:0038133
GeneOntologyBiologicalProcesspostsynaptic density organization

PTPRS LRRC4B SLITRK3

8.14e-0458653GO:0097106
GeneOntologyCellularComponentpostsynaptic density membrane

PTPRS LRRC4B SLITRK3 LRRC7 SLITRK1

1.60e-04157685GO:0098839
DomainVav

VAV3 VAV1 VAV2

4.41e-083673IPR028530
DomainGDS_CDC24_CS

VAV3 VAV1 VAV2 SOS1 SOS2

2.67e-0739675IPR001331
DomainCAMSAP_CH

VAV3 VAV1 VAV2

1.53e-067673PF11971
DomainCAMSAP_CH

VAV3 VAV1 VAV2

1.53e-067673IPR022613
DomainDH_1

VAV3 VAV1 VAV2 SOS1 SOS2

3.05e-0663675PS00741
DomainRhoGEF

VAV3 VAV1 VAV2 SOS1 SOS2

4.47e-0668675SM00325
DomainRhoGEF

VAV3 VAV1 VAV2 SOS1 SOS2

5.16e-0670675PF00621
DomainDH_2

VAV3 VAV1 VAV2 SOS1 SOS2

5.16e-0670675PS50010
DomainDH-domain

VAV3 VAV1 VAV2 SOS1 SOS2

5.53e-0671675IPR000219
Domain-

VAV3 VAV1 VAV2 SOS1 SOS2

5.53e-06716751.20.900.10
Domain-

NLRP7 MFHAS1 LRRC72 LRRC4B SLITRK3 LRRC7 SLITRK1 NLRC4

1.89e-053216783.80.10.10
DomainL_dom-like

NLRP7 MFHAS1 LRRC72 LRRC4B SLITRK3 LRRC7 SLITRK1 NLRC4

2.20e-05328678IPR032675
DomainPOU_dom_5

POU5F1 POU5F1B

3.79e-053672IPR015585
DomainCyt_b245_heavy_chain

CYBB NOX3

7.57e-054672IPR000778
DomainPH

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

1.70e-04229676PF00169
DomainNAD_binding_6

CYBB NOX3

2.63e-047672PF08030
DomainFAD_binding_8

CYBB NOX3

2.63e-047672PF08022
DomainFAD-bd_8

CYBB NOX3

2.63e-047672IPR013112
DomainFe_red_NAD-bd_6

CYBB NOX3

2.63e-047672IPR013121
DomainLRR_8

MFHAS1 LRRC4B SLITRK3 LRRC7 SLITRK1

3.70e-04171675PF13855
DomainLeu-rich_rpt

MFHAS1 LRRC72 LRRC4B SLITRK3 LRRC7 SLITRK1

4.20e-04271676IPR001611
DomainLeu-rich_rpt_typical-subtyp

MFHAS1 LRRC4B SLITRK3 LRRC7 SLITRK1

4.34e-04177675IPR003591
DomainLRR_TYP

MFHAS1 LRRC4B SLITRK3 LRRC7 SLITRK1

4.34e-04177675SM00369
DomainPH

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

4.81e-04278676SM00233
DomainPH_DOMAIN

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

4.90e-04279676PS50003
DomainPH_domain

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

4.99e-04280676IPR001849
DomainALDOKETO_REDUCTASE_1

AKR1E2 AKR1C4

5.60e-0410672PS00798
DomainAldo/ket_reductase_CS

AKR1E2 AKR1C4

5.60e-0410672IPR018170
DomainAldo/keto_reductase

AKR1E2 AKR1C4

5.60e-0410672IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1E2 AKR1C4

5.60e-0410672PS00062
DomainALDOKETO_REDUCTASE_3

AKR1E2 AKR1C4

5.60e-0410672PS00063
DomainENOYL_COA_HYDRATASE

HIBCH EHHADH

5.60e-0410672PS00166
DomainSM22_calponin

VAV3 VAV1

6.83e-0411672IPR003096
DomainLRR

MFHAS1 LRRC72 LRRC4B LRRC7 SLITRK1

7.72e-04201675PS51450
DomainFerric_reduct

CYBB NOX3

8.18e-0412672PF01794
DomainFe3_Rdtase_TM_dom

CYBB NOX3

8.18e-0412672IPR013130
DomainRas_G-nucl-exch_fac_CS

SOS1 SOS2

1.12e-0314672IPR019804
DomainC1_1

VAV3 VAV1 VAV2

1.12e-0357673PF00130
DomainLRR_1

MFHAS1 LRRC4B SLITRK3 LRRC7 SLITRK1

1.13e-03219675PF00560
Domain-

DNHD1 SMARCA5 NWD2 NLRP7 MFHAS1 CDC6 SRCAP NLRC4 EHD4

1.32e-037466793.40.50.300
DomainPOU

POU5F1 POU5F1B

1.47e-0316672SM00352
DomainPOU_2

POU5F1 POU5F1B

1.47e-0316672PS00465
DomainPOU_dom

POU5F1 POU5F1B

1.47e-0316672IPR000327
DomainPOU_3

POU5F1 POU5F1B

1.47e-0316672PS51179
DomainPou

POU5F1 POU5F1B

1.47e-0316672PF00157
Domain-

AKR1E2 AKR1C4

1.47e-03166723.20.20.100
DomainPOU_1

POU5F1 POU5F1B

1.47e-0316672PS00035
DomainZF_DAG_PE_1

VAV3 VAV1 VAV2

1.57e-0364673PS00479
DomainZF_DAG_PE_2

VAV3 VAV1 VAV2

1.57e-0364673PS50081
DomainC1

VAV3 VAV1 VAV2

1.64e-0365673SM00109
DomainCH

VAV3 VAV1 VAV2

1.64e-0365673SM00033
DomainNADP_OxRdtase_dom

AKR1E2 AKR1C4

1.67e-0317672IPR023210
DomainCrotonase_core_superfam

HIBCH EHHADH

1.67e-0317672IPR001753
DomainPOU

POU5F1 POU5F1B

1.67e-0317672IPR013847
DomainAldo_ket_red

AKR1E2 AKR1C4

1.67e-0317672PF00248
DomainECH_1

HIBCH EHHADH

1.67e-0317672PF00378
DomainAldo/ket_red/Kv-b

AKR1E2 AKR1C4

1.67e-0317672IPR001395
DomainPE/DAG-bd

VAV3 VAV1 VAV2

1.72e-0366673IPR002219
DomainCH

VAV3 VAV1 VAV2

2.03e-0370673PF00307
DomainFd_Rdtase_FAD-bd

CYBB NOX3

2.08e-0319672IPR017927
DomainFAD_FR

CYBB NOX3

2.08e-0319672PS51384
DomainRiboflavin_synthase-like_b-brl

CYBB NOX3

2.08e-0319672IPR017938
Domain-

VAV3 VAV1 VAV2

2.12e-03716731.10.418.10
DomainCH

VAV3 VAV1 VAV2

2.29e-0373673PS50021
DomainRasGEFN

SOS1 SOS2

2.31e-0320672SM00229
DomainCH-domain

VAV3 VAV1 VAV2

2.48e-0375673IPR001715
DomainF-box_dom

FBXW10B FBXW10 FBXO32

2.48e-0375673IPR001810
DomainRasGEF_N

SOS1 SOS2

2.55e-0321672PF00618
Domain-

HIBCH EHHADH

2.55e-03216723.90.226.10
DomainClpP/crotonase-like_dom

HIBCH EHHADH

2.55e-0321672IPR029045
Domain-

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

2.76e-033916762.30.29.30
DomainRas-like_Gua-exchang_fac_N

SOS1 SOS2

2.80e-0322672IPR000651
DomainRASGEF_NTER

SOS1 SOS2

2.80e-0322672PS50212
DomainNACHT

NLRP7 NLRC4

3.06e-0323672PS50837
DomainNACHT_NTPase

NLRP7 NLRC4

3.06e-0323672IPR007111
DomainP-loop_NTPase

DNHD1 SMARCA5 NWD2 NLRP7 MFHAS1 CDC6 SRCAP NLRC4 EHD4

3.16e-03848679IPR027417
DomainRASGEF

SOS1 SOS2

3.90e-0326672PS00720
PathwaySA_B_CELL_RECEPTOR_COMPLEXES

VAV3 MAPK3 VAV1 VAV2 SOS1

2.74e-0824545M17200
PathwayREACTOME_RAC1_GTPASE_CYCLE

CYBB ARAP3 NOX3 VAV3 VAV1 VAV2 SOS1 SOS2

3.07e-07175548MM15599
PathwayKEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

3.90e-0775546M5436
PathwayREACTOME_RAC1_GTPASE_CYCLE

CYBB ARAP3 NOX3 VAV3 VAV1 VAV2 SOS1 SOS2

4.51e-07184548M41809
PathwayKEGG_MEDICUS_PATHOGEN_YERSINIA_YOPH_TO_TCR_NFAT_SIGNALING_PATHWAY

VAV3 VAV1 VAV2

5.28e-075543M48994
PathwayKEGG_FC_EPSILON_RI_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

5.33e-0779546M11816
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PTPRS LRRC4B SLITRK3 SLITRK1

8.90e-0720544M27290
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PTPRS LRRC4B SLITRK3 SLITRK1

8.90e-0720544MM14991
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

VAV3 VAV1 VAV2 SOS1 SOS2

1.55e-0652545MM14743
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

SMPD2 VAV3 VAV1 VAV2 SOS1 SOS2

1.80e-0697546M9400
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

VAV3 VAV1 VAV2 SOS1 SOS2

2.92e-0659545M11215
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

VAV3 MAPK3 VAV1 VAV2 SOS1

3.18e-0660545MM14913
PathwayKEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

3.37e-06108546M9904
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

VAV3 VAV1 VAV2 SOS1 SOS2

6.84e-0670545MM14824
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

VAV3 VAV1 VAV2 SOS1 SOS2

1.03e-0576545M19832
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

VAV3 VAV1 VAV2 SOS1 SOS2

1.09e-0577545MM15044
PathwayPID_RAC1_REG_PATHWAY

VAV3 VAV1 VAV2 SOS1

1.29e-0538544M241
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

VAV3 VAV1 VAV2 SOS1 SOS2

1.32e-0580545M800
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

1.33e-05137546M5669
PathwayWP_PDGF_PATHWAY

MAPK3 VAV1 VAV2 SOS1

1.59e-0540544M39555
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

CYBB VAV3 VAV1 VAV2

1.59e-0540544M39695
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

SMPD2 VAV3 VAV1 VAV2 SOS1 SOS2

1.63e-05142546MM15431
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

VAV3 VAV1 VAV2 SOS1 SOS2

1.77e-0585545MM14746
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

1.88e-0514543M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

1.88e-0514543M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

1.88e-0514543M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

1.88e-0514543M47378
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

1.88e-0514543M47488
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

VAV3 MAPK3 VAV1 VAV2 SOS1

1.99e-0587545M27205
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.34e-0515543M47531
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

SMPD2 VAV3 VAV1 VAV2 SOS1 SOS2

2.58e-05154546M27697
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYBB ARAP3 NOX3 SLITRK3 VAV2

2.75e-0593545MM15609
PathwayPID_RHOA_REG_PATHWAY

ARAP3 VAV3 VAV1 VAV2

2.78e-0546544M68
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

CYBB VAV3 VAV1 VAV2

2.78e-0546544MM15837
PathwaySIG_BCR_SIGNALING_PATHWAY

MAPK3 VAV1 SOS1 SOS2

2.78e-0546544M8626
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

CYBB ARAP3 EHHADH NOX3 SLITRK3 VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

2.84e-056495411MM15690
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.87e-0516543M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.87e-0516543M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.87e-0516543M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.87e-0516543M47804
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

MAPK3 SOS1 SOS2

2.87e-0516543M39882
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

2.87e-0516543M47483
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYBB ARAP3 NOX3 SLITRK3 VAV2

2.89e-0594545M41818
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

3.48e-0517543M47376
PathwayWP_CHEMOKINE_SIGNALING

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

3.81e-05165546M39400
PathwayREACTOME_RHO_GTPASE_CYCLE

CYBB ARAP3 NOX3 SLITRK3 VAV3 VAV1 VAV2 SOS1 SOS2

3.89e-05439549MM15595
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

CYBB DCAF1 FBXW10B SEC24D FBXW10 KEAP1 FBXO32 ANAPC5

4.44e-05343548MM15712
PathwayREACTOME_RHO_GTPASE_CYCLE

CYBB ARAP3 NOX3 SLITRK3 VAV3 VAV1 VAV2 SOS1 SOS2

4.71e-05450549M27078
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

VAV3 VAV1 VAV2

4.93e-0519543M47733
PathwayWP_CHEMOKINE_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

7.00e-05184546MM15943
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

VAV3 VAV1 VAV2 SOS1

7.00e-0558544MM14914
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

CYBB DCAF1 FBXW10B SEC24D FBXW10 EHHADH KEAP1 FBXO32 ANAPC5 VAV1 SOS1

7.21e-057195411MM14540
PathwayWP_EGFR1_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

7.88e-05188546MM15828
PathwayKEGG_CHEMOKINE_SIGNALING_PATHWAY

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

7.88e-05188546M4844
PathwayKEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

CYBB NOX3 VAV3 VAV1 VAV2

7.93e-05116545M2164
PathwayREACTOME_AZATHIOPRINE_ADME

VAV3 VAV1 VAV2

8.91e-0523543M45013
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

CYBB NOX3 MAPK3

1.02e-0424543M27553
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

MAPK3 SOS1 SOS2

1.02e-0424543M11190
PathwayKEGG_FOCAL_ADHESION

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

1.08e-04199546M7253
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

CYBB NOX3 MAPK3

1.15e-0425543MM15269
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

PTPRS LRRC4B SLITRK3 SLITRK1

1.23e-0467544MM15327
PathwayREACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY

VAV3 VAV1 VAV2

1.46e-0427543M27422
PathwaySIG_IL4RECEPTOR_IN_B_LYPHOCYTES

MAPK3 SOS1 SOS2

1.46e-0427543M1718
PathwayREACTOME_AZATHIOPRINE_ADME

VAV3 VAV1 VAV2

1.46e-0427543MM15693
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

1.56e-04213546M18306
PathwayREACTOME_DAP12_SIGNALING

VAV3 VAV2 SOS1

1.81e-0429543M27171
PathwayREACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY

VAV3 VAV1 VAV2

2.00e-0430543MM15170
PathwayWP_PROLACTIN_SIGNALING

MAPK3 VAV1 VAV2 SOS1

2.01e-0476544M39601
PathwayREACTOME_DAP12_SIGNALING

VAV3 VAV2 SOS1

2.21e-0431543MM14886
PathwayBIOCARTA_BCR_PATHWAY

MAPK3 VAV1 SOS1

2.44e-0432543MM1355
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

VAV3 MAPK3 VAV1 VAV2 SOS1

2.65e-04150545MM14889
PathwayWP_MAPK_CASCADE

MAPK3 SOS1 SOS2

2.67e-0433543M39594
PathwayBIOCARTA_BCR_PATHWAY

MAPK3 VAV1 SOS1

2.67e-0433543M9494
PathwayKEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY

MAPK3 SOS1 SOS2

3.19e-0435543M47379
PathwayREACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE

VAV3 VAV1 VAV2

3.19e-0435543MM14512
PathwayREACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE

VAV3 VAV1 VAV2

3.19e-0435543M773
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

VAV3 VAV1 VAV2 SOS1

3.24e-0486544M27206
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

PTPRS LRRC4B SLITRK3 SLITRK1

3.38e-0487544M27617
PathwayREACTOME_RAC2_GTPASE_CYCLE

CYBB VAV3 VAV1 VAV2

3.38e-0487544MM15600
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

CYBB ARAP3 NOX3 SLITRK3 VAV3 MAPK3 VAV1 VAV2 SOS1 SOS2

3.52e-047205410M41838
PathwayREACTOME_RAC2_GTPASE_CYCLE

CYBB VAV3 VAV1 VAV2

3.53e-0488544M41810
PathwayWP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE

CYBB NOX3 MAPK3

3.76e-0437543M45513
PathwayWP_EGFEGFR_SIGNALING

VAV3 VAV1 VAV2 SOS1 SOS2

3.78e-04162545M39334
PathwayWP_TCELL_RECEPTOR_SIGNALING

VAV3 MAPK3 VAV1 SOS1

3.85e-0490544M39725
PathwayWP_MIRNAS_AND_TFS_IN_IPS_CELL_GENERATION

POU5F1 POU5F1B

3.97e-048542MM15855
Pubmed

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.

VAV3 VAV1 VAV2 SOS1 SOS2

1.93e-111268515728722
Pubmed

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

CYBB VAV3 VAV1 VAV2

2.00e-10668417984307
Pubmed

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

VAV3 VAV1 VAV2

7.15e-09368317054426
Pubmed

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.

VAV3 VAV1 VAV2

7.15e-09368326240279
Pubmed

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

VAV3 VAV1 VAV2

7.15e-09368323935450
Pubmed

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.

VAV3 VAV1 VAV2

7.15e-09368332963234
Pubmed

Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

VAV3 VAV1 VAV2

7.15e-09368314623913
Pubmed

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.

VAV3 VAV1 VAV2

7.15e-0936838990121
Pubmed

Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.

VAV3 VAV1 VAV2

7.15e-09368332528129
Pubmed

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

VAV3 VAV1 VAV2

7.15e-09368329136506
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

VAV3 VAV1 VAV2 SOS1 SOS2

1.17e-083868511756498
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

VAV3 VAV1 VAV2 SOS1 SOS2

2.24e-084368512376548
Pubmed

Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.

VAV3 VAV1 VAV2

2.86e-08468319139088
Pubmed

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.

VAV3 VAV1 VAV2

2.86e-08468317932569
Pubmed

The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.

VAV3 VAV1 VAV2

2.86e-08468320038798
Pubmed

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

VAV3 VAV1 VAV2

2.86e-08468322692505
Pubmed

Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene.

VAV3 VAV1 VAV2

2.86e-08468321115475
Pubmed

Vav proteins control MyD88-dependent oxidative burst.

VAV3 VAV1 VAV2

2.86e-08468317158234
Pubmed

Vav proteins regulate the plasma cell program and secretory Ig production.

VAV3 VAV1 VAV2

2.86e-08468317142761
Pubmed

The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.

VAV3 VAV1 VAV2

2.86e-08468320011522
Pubmed

Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

VAV3 VAV1 VAV2

7.13e-08568315456756
Pubmed

Vav family GEFs link activated Ephs to endocytosis and axon guidance.

VAV3 VAV1 VAV2

7.13e-08568315848800
Pubmed

Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

VAV3 VAV1 VAV2

7.13e-08568315365099
Pubmed

ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.

VAV3 VAV1 VAV2

7.13e-08568320634378
Pubmed

Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.

VAV3 VAV1 VAV2

7.13e-08568321209086
Pubmed

Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.

VAV3 VAV1 VAV2

7.13e-08568319715691
Pubmed

Vav proteins regulate peripheral B-cell survival.

VAV3 VAV1 VAV2

7.13e-08568315941910
Pubmed

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

VAV3 VAV1 VAV2

7.13e-08568322884313
Pubmed

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

VAV3 VAV1 VAV2 SOS1 SOS2

1.24e-076068512787561
Pubmed

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.

VAV3 VAV1 VAV2

1.42e-07668324091327
Pubmed

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

VAV3 VAV1 VAV2

1.42e-07668325538043
Pubmed

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.

POU5F1 POU5F1B MAPK3

1.42e-07668314502223
Pubmed

Vav family proteins couple to diverse cell surface receptors.

VAV3 VAV1 VAV2

1.42e-07668310938113
Pubmed

Interaction of Ras with p110γ is required for thymic β-selection in the mouse.

VAV3 VAV1 VAV2

1.42e-07668321930962
Pubmed

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

VAV3 VAV1 VAV2

1.42e-07668327926862
Pubmed

Rac GTPases play critical roles in early T-cell development.

VAV3 VAV1 VAV2

1.42e-07668319088377
Pubmed

Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

VAV3 VAV1 VAV2

1.42e-07668316546099
Pubmed

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

VAV1 SOS1 SOS2

1.42e-07668314764585
Pubmed

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.

VAV3 VAV1 VAV2

2.49e-07768321979919
Pubmed

Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.

MAPK3 SOS1 SOS2

2.49e-07768315173068
Pubmed

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

VAV3 VAV1 VAV2

2.49e-07768320308364
Pubmed

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.

VAV3 VAV1 VAV2

2.49e-07768321178006
Pubmed

Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively.

VAV1 SOS1 SOS2

2.49e-0776838276400
Pubmed

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases.

PTPRS SLITRK3 SLITRK1

2.49e-07768323345436
Pubmed

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.

VAV3 VAV1 VAV2

3.98e-07868324659802
Pubmed

Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

VAV3 VAV1 VAV2

5.95e-07968324155889
Pubmed

Radixin regulates cell migration and cell-cell adhesion through Rac1.

VAV3 VAV1 VAV2

5.95e-07968322467863
Pubmed

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

VAV3 VAV1 VAV2

8.49e-071068328930674
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

VAV3 VAV2 SOS1 SOS2

9.38e-073868419911011
Pubmed

Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.

VAV3 VAV1 VAV2

1.17e-061168319141316
Pubmed

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

VAV3 VAV1 VAV2

1.17e-061168322683124
Pubmed

CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.

VAV3 VAV1 VAV2

1.55e-06126839269777
Pubmed

Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.

VAV3 VAV2

3.77e-06268223931752
Pubmed

Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage.

POU5F1 POU5F1B

3.77e-06268231843009
Pubmed

Characterization of novel alternative splicing variants of Oct4 gene expressed in mouse pluripotent stem cells.

POU5F1 POU5F1B

3.77e-06268229266259
Pubmed

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.

VAV3 VAV2

3.77e-06268235534539
Pubmed

Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.

VAV1 VAV2

3.77e-06268216150693
Pubmed

Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression.

POU5F1 POU5F1B

3.77e-06268215685634
Pubmed

Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.

VAV1 VAV2

3.77e-06268216137676
Pubmed

Regulatory Elements Outside Established Pou5f1 Gene Boundaries Are Required for Multilineage Differentiation of Embryonic Stem Cells.

POU5F1 POU5F1B

3.77e-06268237895112
Pubmed

Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.

POU5F1 POU5F1B

3.77e-06268216950240
Pubmed

Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.

POU5F1 POU5F1B

3.77e-06268218837968
Pubmed

[Investigation of transcriptional regulation of Oct4 (POU5F1) gene with distal enhancer].

POU5F1 POU5F1B

3.77e-06268225509123
Pubmed

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.

VAV3 VAV2

3.77e-06268230087437
Pubmed

Cruciform Formable Sequences within Pou5f1 Enhancer Are Indispensable for Mouse ES Cell Integrity.

POU5F1 POU5F1B

3.77e-06268233810223
Pubmed

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

POU5F1 POU5F1B

3.77e-06268218063756
Pubmed

Neural stem cells express Oct-3/4.

POU5F1 POU5F1B

3.77e-06268219664601
Pubmed

Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency.

POU5F1 POU5F1B

3.77e-06268228157483
Pubmed

Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.

POU5F1 POU5F1B

3.77e-06268219784378
Pubmed

Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.

POU5F1 POU5F1B

3.77e-06268228988986
Pubmed

Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos.

POU5F1 POU5F1B

3.77e-06268218932201
Pubmed

B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.

VAV3 VAV1

3.77e-06268219586920
Pubmed

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

VAV1 VAV2

3.77e-0626828710375
Pubmed

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

POU5F1 POU5F1B

3.77e-0626821972777
Pubmed

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.

POU5F1 POU5F1B

3.77e-0626821915274
Pubmed

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling.

VAV1 VAV2

3.77e-06268211376343
Pubmed

Strongly reduced alloreactivity and long-term survival times of cardiac allografts in Vav1- and Vav1/Vav2-knockout mice.

VAV1 VAV2

3.77e-06268217326776
Pubmed

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation.

VAV1 VAV2

3.77e-06268211376342
Pubmed

Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex.

POU5F1 POU5F1B

3.77e-0626821680810
Pubmed

Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells.

POU5F1 POU5F1B

3.77e-06268220376339
Pubmed

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

POU5F1 POU5F1B

3.77e-06268230653498
Pubmed

Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects.

VAV3 VAV2

3.77e-06268223402756
Pubmed

Identification and structural basis for a novel interaction between Vav2 and Arap3.

ARAP3 VAV2

3.77e-06268222750419
Pubmed

Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.

POU5F1 POU5F1B

3.77e-06268215996113
Pubmed

Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction.

POU5F1 POU5F1B

3.77e-06268221083502
Pubmed

Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.

POU5F1 POU5F1B

3.77e-06268226804242
Pubmed

Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.

POU5F1 POU5F1B

3.77e-06268221502535
Pubmed

OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.

POU5F1 POU5F1B

3.77e-06268227499297
Pubmed

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.

POU5F1 POU5F1B

3.77e-06268211839818
Pubmed

Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.

POU5F1 POU5F1B

3.77e-06268234948221
Pubmed

Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.

VAV3 VAV2

3.77e-06268228157227
Pubmed

A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.

POU5F1 POU5F1B

3.77e-06268233221301
Pubmed

Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences.

POU5F1 POU5F1B

3.77e-06268211309664
Pubmed

Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.

POU5F1 POU5F1B

3.77e-06268212641567
Pubmed

A nontranscriptional role for Oct4 in the regulation of mitotic entry.

POU5F1 POU5F1B

3.77e-06268225324523
Pubmed

A novel subpopulation lacking Oct4 expression in the testicular side population.

POU5F1 POU5F1B

3.77e-06268216328007
Pubmed

Novel variants of Oct-3/4 gene expressed in mouse somatic cells.

POU5F1 POU5F1B

3.77e-06268218765667
Pubmed

Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.

POU5F1 POU5F1B

3.77e-06268218283123
Pubmed

Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.

POU5F1 POU5F1B

3.77e-06268222832160
Pubmed

De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4.

POU5F1 POU5F1B

3.77e-06268216932739
Cytoband10p15.1

AKR1E2 AKR1C4

7.97e-042868210p15.1
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

VAV3 VAV1 VAV2 SOS1 SOS2

6.06e-0766455722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARAP3 VAV3 VAV1 VAV2 SOS1 SOS2

1.14e-05206456682
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10B FBXW10

3.28e-0411452559
GeneFamilyAldo-keto reductases

AKR1E2 AKR1C4

6.23e-0415452399
GeneFamilyPOU class homeoboxes and pseudogenes

POU5F1 POU5F1B

1.48e-0323452523
GeneFamilyNLR family

NLRP7 NLRC4

1.75e-0325452666
GeneFamilySH2 domain containing

VAV3 VAV1 VAV2

2.03e-03101453741
CoexpressionGSE16450_CTRL_VS_IFNA_6H_STIM_MATURE_NEURON_CELL_LINE_UP

CYBB NWD2 TBC1D14 RANBP6 AKR1C4 SLITRK1

1.31e-05199686M7420
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

DCAF1 RNF214 SEC24D HIBCH PTPRS TMEM216 SLC25A10 KEAP1 MAPK3 CDC6

3.01e-057766810M1107
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

DCAF1 RNF214 SEC24D HIBCH PTPRS TMEM216 SLC25A10 KEAP1 MAPK3 CDC6

3.65e-057946810MM982
DiseaseGilles de la Tourette syndrome (is_implicated_in)

HCN4 SLITRK1

7.13e-056652DOID:11119 (is_implicated_in)
Diseaseresponse to risperidone

CNTNAP5 ATF7IP2 USP48

8.15e-0538653GO_0097336
DiseaseRAC-beta serine/threonine-protein kinase measurement

EHHADH APOC4

3.67e-0413652EFO_0021989
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

SOS1 SOS2

7.98e-0419652C3501846
DiseaseCostello syndrome (disorder)

SOS1 SOS2

7.98e-0419652C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

SOS1 SOS2

7.98e-0419652C1843181
DiseaseCardio-facio-cutaneous syndrome

SOS1 SOS2

7.98e-0419652C1275081
Diseasealpha-tocopherol measurement

RNF215 SOS1

8.85e-0420652EFO_0007898
Diseaseserum IgG glycosylation measurement

VN1R4 CNTNAP5 EHHADH TBC1D14 VAV2 SOS2

1.03e-03523656EFO_0005193
DiseaseLEOPARD Syndrome

SOS1 SOS2

1.07e-0322652C0175704
DiseaseNoonan Syndrome

SOS1 SOS2

1.28e-0324652C0028326
Diseasemultiple myeloma

POU5F1 SRCAP SOS1

1.96e-03112653EFO_0001378

Protein segments in the cluster

PeptideGeneStartEntry
SNFNCRQLEMILNKP

AKR1C4

166

P17516
RPNLLKNMTQLLCVE

ARAP3

626

Q8WWN8
ALNQMCTRNLALLFA

ARAP3

1046

Q8WWN8
FQKCLVNIQALLMDP

CATSPERD

366

Q86XM0
LMLIQKLLNENPFKC

AKAP4

631

Q5JQC9
LQMCNPKLLLTAANV

FBXW10

141

Q5XX13
VKALSQLQNLLPLFC

DNHD1

3861

Q96M86
MSLLRNRLQALPALC

APOC4

1

P55056
LCQPLDVLKTRLMNS

SLC25A10

216

Q9UBX3
NNALSKCTLPMFVNL

NWD2

601

Q9ULI1
LLEHNPNLLFMLKCR

RANBP10

321

Q6VN20
LNRPKFLNALTLNMI

HIBCH

51

Q6NVY1
CPQLANSVQIRIKLM

ANAPC5

86

Q9UJX4
LQMCNPKLLLTAANV

FBXW10B

141

O95170
QLSFKNMCKLRPLLQ

POU5F1B

191

Q06416
SKLPLFSSCQIQQLM

DCAF1

776

Q9Y4B6
RQPMLLFLCQLSAIE

OR10AC1

56

Q8NH08
QKSRCLRNLMKTPLF

NLRC4

326

Q9NPP4
PAQFSCLQRLKMLNL

MFHAS1

266

Q9Y4C4
CLQRLKMLNLSSNLF

MFHAS1

271

Q9Y4C4
LPKQLFNCQALRKLS

LRRC7

61

Q96NW7
RRLCNKPIQSLPNMD

EHHADH

196

Q08426
CLELQPNNLKALMAL

PEX5L

386

Q8IYB4
RFLCKMNPSQALKVR

INTS2

251

Q9H0H0
LNRFMCSQLPNQVLK

EHD4

136

Q9H223
CIINMKARNYLQSLP

MAPK3

271

P27361
IINFNCRKLVASMPL

HCN4

581

Q9Y3Q4
QLSFKNMCKLRPLLQ

POU5F1

191

Q01860
NLPCNKFKNRLVNIM

PTPRS

1701

Q13332
MKPNFSLRLRIFNLN

SMPD2

1

O60906
QDRILPNLSCMFALL

C1orf112

686

Q9NSG2
SFPLQQKILVCSLML

CDC6

456

Q99741
NMNNCSLILKFRELI

C3orf33

271

Q6P1S2
KTVLLFQRNCLKPNM

ATF7IP2

376

Q5U623
NFNCMLILLPVCRNL

CYBB

61

P04839
LTPNFLQMQLQKCEI

KEAP1

276

Q14145
ACLQPSQDPQMRLKL

DNAAF5

611

Q86Y56
TDLPLCLQLNIMQRL

FBXO32

226

Q969P5
QCLNPIKAFQGCMRL

CNTNAP5

501

Q8WYK1
MCNLKDIPNLTALVR

LRRC4B

216

Q9NT99
MLNLKILSLYQNPLC

LRRC72

136

A6NJI9
SLAVQAFLQMCNLPI

MTX2

41

O75431
PLLFLACQLFVINMK

TAS2R31

136

P59538
LIFQLLNKLCMAQPR

SOS2

51

Q07890
NPPCRQKSLQMTFAL

NBR1

666

Q14596
SLMPNLKLLFLNNNL

SLITRK3

501

O94933
LMLQQTCPLCKFNVL

RNF215

356

Q9Y6U7
PKHFLQMLSLENCRL

NLRP7

816

Q8WX94
INILMQLRKVCNHPN

SRCAP

891

Q6ZRS2
LILQLLNMLCQAQPR

SOS1

51

Q07889
LNFNCMLILIPVSRN

NOX3

61

Q9HBY0
QLLKNLINPSCMVRR

RANBP6

21

O60518
MNCLLKNCVLLSRPE

SEC24D

846

O94855
FCLRLMLKNPENHAL

GTF3C3

721

Q9Y5Q9
LNRNLRLAMFPITKN

AKR1E2

296

Q96JD6
MQKRPLAPSCNELQF

TECTA

1656

O75443
SNLLNKPCQMAFFRV

TBC1D14

531

Q9P2M4
KLLTRFPQCNKAQMT

RNF214

561

Q8ND24
LGNTQNFMLLCPRLK

TSR1

116

Q2NL82
TFNAMPKLRILILNN

SLITRK1

466

Q96PX8
ENNPEMKCLRNLISL

RFX8

346

Q6ZV50
NLRPQMSQFLCLKNI

VAV1

61

P15498
RLMNRPQAILNCVNK

RIMKLB

101

Q9ULI2
CKAQMLENPSIQRLL

UBQLNL

171

Q8IYU4
LFQVCMALLDNPNSL

VN1R4

251

Q7Z5H5
LARPKSLMQKLQCSF

ZBTB10

236

Q96DT7
NFRPQMSQFLCLKNI

VAV2

61

P52735
LLNILMQLRKCCNHP

SMARCA5

446

O60264
LSLPCTLNLQLMRFV

USP48

286

Q86UV5
NLCQRKMPLSISVAL

TMEM216

81

Q9P0N5
NLRPQMSQFLCLKNI

VAV3

61

Q9UKW4