Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 FZD3 TAS2R36 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 TAS2R45 CALCRL TAS2R30 TAS2R46 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2 OR51F1 OR10D4P	3.15e-23	884	52	27	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 FZD3 TAS2R36 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 TAS2R45 CALCRL TAS2R30 TAS2R46 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CHRNE CXCR1 CXCR2 OR51F1 OR10D4P	1.24e-19	1353	52	28	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	5.45e-11	431	52	13	GO:0004984
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	7.60e-09	27	52	5	GO:0033038
GeneOntologyMolecularFunction	taste receptor activity	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	2.21e-08	33	52	5	GO:0008527
GeneOntologyMolecularFunction	interleukin-8 receptor activity	CXCR1 CXCR2	6.65e-06	2	52	2	GO:0004918
GeneOntologyMolecularFunction	odorant binding	OR6B3 OR5H14 OR5H1 OR6B2 OR14A16	1.97e-05	127	52	5	GO:0005549
GeneOntologyMolecularFunction	interleukin-8 binding	CXCR1 CXCR2	1.99e-05	3	52	2	GO:0019959
GeneOntologyMolecularFunction	C-X-C chemokine binding	CXCR1 CXCR2	1.39e-04	7	52	2	GO:0019958
GeneOntologyMolecularFunction	C-X-C chemokine receptor activity	CXCR1 CXCR2	1.84e-04	8	52	2	GO:0016494
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CXCR1 CXCR2	1.62e-03	23	52	2	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CXCR1 CXCR2	1.77e-03	24	52	2	GO:0019957
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CXCR1 CXCR2	2.08e-03	26	52	2	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CXCR1 CXCR2	2.08e-03	26	52	2	GO:0004950
GeneOntologyMolecularFunction	chemokine binding	CXCR1 CXCR2	3.34e-03	33	52	2	GO:0019956
GeneOntologyMolecularFunction	Wnt-protein binding	FZD3 APCDD1L	3.54e-03	34	52	2	GO:0017147
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	GPR84 CALCRL SSTR5	5.03e-03	133	52	3	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	GPR84 CALCRL SSTR5	5.80e-03	140	52	3	GO:0001653
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 FZD3 TAS2R36 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 TAS2R45 CALCRL TAS2R30 TAS2R46 SSTR5 OR5H1 OR6B2 SLC1A1 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2 OR51F1 OR10D4P	1.19e-19	1395	52	28	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	7.21e-17	485	52	18	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	2.79e-16	524	52	18	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	5.91e-16	547	52	18	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	1.74e-15	582	52	18	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	7.07e-14	722	52	18	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	3.77e-11	432	52	13	GO:0050911
GeneOntologyBiologicalProcess	sensory perception	OR52R1 TAS2R8 OR2A12 OR6B3 TAS2R36 OR52N4 OR1C1 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	5.28e-11	1072	52	18	GO:0007600
GeneOntologyBiologicalProcess	sensory perception of smell	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	9.38e-11	465	52	13	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of bitter taste	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	8.43e-08	44	52	5	GO:0001580
GeneOntologyBiologicalProcess	sensory perception of bitter taste	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	1.32e-07	48	52	5	GO:0050913
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	1.63e-07	50	52	5	GO:0050912
GeneOntologyBiologicalProcess	sensory perception of taste	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	8.94e-07	70	52	5	GO:0050909
GeneOntologyBiologicalProcess	interleukin-8-mediated signaling pathway	CXCR1 CXCR2	6.23e-06	2	52	2	GO:0038112
GeneOntologyBiologicalProcess	cellular response to interleukin-8	CXCR1 CXCR2	1.87e-05	3	52	2	GO:0098759
GeneOntologyBiologicalProcess	response to interleukin-8	CXCR1 CXCR2	1.87e-05	3	52	2	GO:0098758
GeneOntologyBiologicalProcess	response to mercury ion	SLC34A1 SLC1A1	5.56e-04	14	52	2	GO:0046689
Domain	GPCR_Rhodpsn_7TM	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2	7.35e-16	670	47	19	IPR017452
Domain	G_PROTEIN_RECEP_F1_2	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2	1.29e-15	691	47	19	PS50262
Domain	GPCR_Rhodpsn	GPR4 OR52R1 TAS2R8 OR2A12 OR6B3 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2	1.33e-15	692	47	19	IPR000276
Domain	7tm_1	GPR4 OR52R1 OR2A12 OR6B3 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2	1.60e-14	677	47	18	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR4 OR52R1 OR2A12 OR6B3 OR52N4 GPR78 GPR152 GPR84 OR1C1 OR5H14 SSTR5 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 CXCR1 CXCR2	1.95e-14	685	47	18	PS00237
Domain	Olfact_rcpt	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6	2.75e-09	393	47	11	IPR000725
Domain	TAS2R	TAS2R8 TAS2R45 TAS2R30 TAS2R46	5.05e-07	26	47	4	PF05296
Domain	T2R	TAS2R8 TAS2R45 TAS2R30 TAS2R46	5.05e-07	26	47	4	IPR007960
Domain	Chemokine_CXCR_1/2	CXCR1 CXCR2	6.20e-06	2	47	2	IPR000174
Domain	CXCR4/ACKR2	CXCR1 CXCR2	1.29e-04	7	47	2	IPR001277
Domain	PI3/4_kinase_CS	ATR PIK3CA	6.37e-04	15	47	2	IPR018936
Domain	PI3Kc	ATR PIK3CA	7.27e-04	16	47	2	SM00146
Domain	-	ATR PIK3CA	7.27e-04	16	47	2	1.10.1070.11
Domain	PI3_4_KINASE_1	ATR PIK3CA	9.24e-04	18	47	2	PS00915
Domain	PI3_4_KINASE_2	ATR PIK3CA	9.24e-04	18	47	2	PS00916
Domain	PI3/4_kinase_cat_dom	ATR PIK3CA	9.24e-04	18	47	2	IPR000403
Domain	PI3_PI4_kinase	ATR PIK3CA	9.24e-04	18	47	2	PF00454
Domain	PI3_4_KINASE_3	ATR PIK3CA	9.24e-04	18	47	2	PS50290
Domain	GPCR_2-like	FZD3 CALCRL	1.00e-02	60	47	2	IPR017981
Domain	GPCR_2_secretin-like	FZD3 CALCRL	1.00e-02	60	47	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	FZD3 CALCRL	1.03e-02	61	47	2	PS50261
Pathway	REACTOME_SENSORY_PERCEPTION	OR52R1 TAS2R8 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 TAS2R30 TAS2R46 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1	5.09e-11	636	39	15	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR5H1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1	7.28e-10	417	39	12	M4072
Pathway	WP_GPCRS_ODORANT	GPR4 GPR152 GPR84 OR5H14 TAS2R45 TAS2R30 TAS2R46 OR5H1	9.08e-09	157	39	8	MM15872
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1	7.10e-08	389	39	10	M14091
Pathway	REACTOME_SIGNALING_BY_GPCR	GPR4 TAS2R8 FZD3 PIK3CA GPR84 CALCRL TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	2.01e-06	702	39	11	M746
Pathway	REACTOME_GPCR_LIGAND_BINDING	GPR4 TAS2R8 FZD3 CALCRL TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	3.63e-06	463	39	9	M507
Pathway	REACTOME_SIGNALING_BY_GPCR	GPR4 PIK3CA GPR84 TAS2R45 CALCRL TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	7.24e-06	646	39	10	MM14962
Pathway	REACTOME_GPCR_LIGAND_BINDING	GPR4 TAS2R45 CALCRL TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	1.88e-05	430	39	8	MM15160
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R45 TAS2R30 TAS2R46	8.34e-05	31	39	3	MM15691
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	TAS2R45 TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	1.30e-04	289	39	6	MM15057
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R45 TAS2R30 TAS2R46	1.43e-04	37	39	3	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R8 TAS2R30 TAS2R46	1.67e-04	39	39	3	M793
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	TAS2R8 TAS2R30 TAS2R46 SSTR5 CXCR1 CXCR2	2.04e-04	314	39	6	M600
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R8 TAS2R30 TAS2R46	2.92e-04	47	39	3	M42524
Pathway	KEGG_TASTE_TRANSDUCTION	TAS2R8 TAS2R45 TAS2R46	3.94e-04	52	39	3	M5785
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR4 OR1C1 SSTR5 CXCR1 CXCR2	7.08e-04	260	39	5	M39397
Pathway	WP_GPCRS_NONODORANT	FZD3 CALCRL SSTR5 CXCR1 CXCR2	7.85e-04	266	39	5	MM15843
Pubmed	The human olfactory receptor gene family.	OR52R1 OR2A12 OR6B3 OR52N4 OR1C1 OR5H14 OR6B2 OR1J4 OR14A16 OR52B6 OR51F1 OR10D4P	2.66e-11	541	53	12	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52R1 OR2A12 OR6B3 OR52N4 OR5H14 OR5H1 OR6B2 OR1J4 OR51F1 OR10D4P	9.39e-11	340	53	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52R1 OR2A12 OR6B3 OR52N4 OR5H14 OR5H1 OR6B2 OR1J4 OR51F1 OR10D4P	9.39e-11	340	53	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52R1 OR2A12 OR6B3 OR52N4 OR5H14 OR5H1 OR6B2 OR1J4 OR51F1 OR10D4P	1.02e-10	343	53	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52R1 OR2A12 OR6B3 OR52N4 OR5H14 OR5H1 OR6B2 OR1J4 OR51F1 OR10D4P	1.11e-10	346	53	10	14611657
Pubmed	A novel family of mammalian taste receptors.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	2.82e-08	21	53	4	10761934
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	4.16e-08	23	53	4	20022913
Pubmed	Receptors for bitter and sweet taste.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	5.94e-08	25	53	4	12139982
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	7.01e-08	26	53	4	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	8.22e-08	27	53	4	12581520
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R8 TAS2R45 TAS2R30 TAS2R46	9.57e-08	28	53	4	15744053
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R45 TAS2R30 TAS2R46	7.28e-07	12	53	3	12379855
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR1C1 OR5H14 OR5H1 OR14A16	7.48e-07	46	53	4	32126975
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R45 TAS2R30 TAS2R46	9.45e-07	13	53	3	15938754
Pubmed	Effects of CXCR1 and CXCR2 inhibition on expansion and differentiation of umbilical cord blood CD133(+) cells into megakaryocyte progenitor cells.	CXCR1 CXCR2	2.28e-06	2	53	2	21555225
Pubmed	CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.	CXCR1 CXCR2	2.28e-06	2	53	2	19401689
Pubmed	Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.	CXCR1 CXCR2	2.28e-06	2	53	2	19585580
Pubmed	CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.	CXCR1 CXCR2	2.28e-06	2	53	2	21254176
Pubmed	Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.	CXCR1 CXCR2	2.28e-06	2	53	2	15772681
Pubmed	Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.	CXCR1 CXCR2	2.28e-06	2	53	2	30218547
Pubmed	A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.	CXCR1 CXCR2	2.28e-06	2	53	2	17360650
Pubmed	Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India.	CXCR1 CXCR2	2.28e-06	2	53	2	22171941
Pubmed	Low expression of CXCR1/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure.	CXCR1 CXCR2	2.28e-06	2	53	2	27974825
Pubmed	Association between interleukin 8-receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects.	CXCR1 CXCR2	2.28e-06	2	53	2	29577511
Pubmed	Collagen-Derived N-Acetylated Proline-Glycine-Proline in Intervertebral Discs Modulates CXCR1/2 Expression and Activation in Cartilage Endplate Stem Cells to Induce Migration and Differentiation Toward a Pro-Inflammatory Phenotype.	CXCR1 CXCR2	2.28e-06	2	53	2	26302999
Pubmed	Elevated expression of the interleukin-8 receptors CXCR1 and CXCR2 in peripheral blood cells in obstructive coronary artery disease.	CXCR1 CXCR2	2.28e-06	2	53	2	21915051
Pubmed	Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.	CXCR1 CXCR2	2.28e-06	2	53	2	8384312
Pubmed	The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.	CXCR1 CXCR2	2.28e-06	2	53	2	18668539
Pubmed	Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro.	CXCR1 CXCR2	2.28e-06	2	53	2	25022956
Pubmed	Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?	CXCR1 CXCR2	2.28e-06	2	53	2	16987681
Pubmed	Bronchoepithelial expression of CXCR1 and CXCR2 does not facilitate transepithelial migration of neutrophils.	CXCR1 CXCR2	2.28e-06	2	53	2	22076427
Pubmed	Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.	CXCR1 CXCR2	2.28e-06	2	53	2	7829970
Pubmed	Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases.	CXCR1 CXCR2	2.28e-06	2	53	2	12442335
Pubmed	Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses.	ATR SLC34A1	2.28e-06	2	53	2	31589169
Pubmed	CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.	CXCR1 CXCR2	2.28e-06	2	53	2	26087179
Pubmed	Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.	CXCR1 CXCR2	2.28e-06	2	53	2	22152684
Pubmed	[Diagnostic efficiency of determining CXCR1, CXCR2 and hyaluronic acid blood level in non-small cell lung cancer patients].	CXCR1 CXCR2	2.28e-06	2	53	2	34730557
Pubmed	Roles of mechanical force and CXCR1/CXCR2 in shear-stress-induced endothelial cell migration.	CXCR1 CXCR2	2.28e-06	2	53	2	21989491
Pubmed	Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2.	CXCR1 CXCR2	2.28e-06	2	53	2	12239185
Pubmed	Regulation of CXCR/IL-8 in human airway epithelial cells.	CXCR1 CXCR2	2.28e-06	2	53	2	20016196
Pubmed	Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis.	CXCR1 CXCR2	2.28e-06	2	53	2	15793866
Pubmed	Human T lymphocytes and mast cells differentially express and regulate extra- and intracellular CXCR1 and CXCR2.	CXCR1 CXCR2	2.28e-06	2	53	2	15265017
Pubmed	CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease.	CXCR1 CXCR2	2.28e-06	2	53	2	22088968
Pubmed	Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil.	CXCR1 CXCR2	2.28e-06	2	53	2	26847910
Pubmed	Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.	CXCR1 CXCR2	2.28e-06	2	53	2	30341468
Pubmed	Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.	CXCR1 CXCR2	2.28e-06	2	53	2	7929358
Pubmed	CXCR1 and CXCR2 are novel mechano-sensors mediating laminar shear stress-induced endothelial cell migration.	CXCR1 CXCR2	2.28e-06	2	53	2	21036625
Pubmed	[Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice].	CXCR1 CXCR2	2.28e-06	2	53	2	20082763
Pubmed	The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.	CXCR1 CXCR2	2.28e-06	2	53	2	20044480
Pubmed	CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.	CXCR1 CXCR2	2.28e-06	2	53	2	26791948
Pubmed	Interleukin-8 in the human fallopian tube.	CXCR1 CXCR2	2.28e-06	2	53	2	11397869
Pubmed	Expression of interleukin-8 receptors in endometriosis.	CXCR1 CXCR2	2.28e-06	2	53	2	15618253
Pubmed	Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype.	CXCR1 CXCR2	2.28e-06	2	53	2	14713106
Pubmed	Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.	CXCR1 CXCR2	2.28e-06	2	53	2	27551720
Pubmed	[The role of CXCR1/2 in shear stress-induced endothelial cell migration].	CXCR1 CXCR2	2.28e-06	2	53	2	19634663
Pubmed	Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites.	CXCR1 CXCR2	2.28e-06	2	53	2	17996233
Pubmed	On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.	CXCR1 CXCR2	2.28e-06	2	53	2	15028716
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R45 TAS2R30 TAS2R46	5.04e-06	22	53	3	12734386
Pubmed	Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library.	CXCR1 CXCR2	6.83e-06	3	53	2	19118103
Pubmed	Interleukin-8 is related to poor chemotherapeutic response and tumourigenicity in hepatocellular carcinoma.	CXCR1 CXCR2	6.83e-06	3	53	2	24161763
Pubmed	Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2.	CXCR1 CXCR2	6.83e-06	3	53	2	17295203
Pubmed	Inhibition of interleukin 8/C‑X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells.	CXCR1 CXCR2	6.83e-06	3	53	2	29749433
Pubmed	CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.	CXCR1 CXCR2	6.83e-06	3	53	2	22996693
Pubmed	A Preliminary Report of the Relationship Between Gene Polymorphism of IL-8 and Its Receptors and Systemic Inflammatory Response Syndrome Caused by Wasp Stings.	CXCR1 CXCR2	6.83e-06	3	53	2	31613654
Pubmed	Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma.	CXCR1 CXCR2	6.83e-06	3	53	2	15598788
Pubmed	Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos, independent of Ras and Raf-1 in Chinese hamster ovary cells.	CXCR1 CXCR2	6.83e-06	3	53	2	9843397
Pubmed	Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny.	CXCR1 CXCR2	6.83e-06	3	53	2	11007922
Pubmed	The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma.	CXCR1 CXCR2	6.83e-06	3	53	2	26267317
Pubmed	CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.	CXCR1 CXCR2	6.83e-06	3	53	2	21749879
Pubmed	Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.	CXCR1 CXCR2	6.83e-06	3	53	2	11196695
Pubmed	[Influence of IFN on expression of chemokine receptor CXCR1, CXCR2 and their ligand IL-8 in the patients with chronic hepatitis B].	CXCR1 CXCR2	6.83e-06	3	53	2	22482416
Pubmed	Structure and functional expression of a human interleukin-8 receptor.	CXCR1 CXCR2	6.83e-06	3	53	2	1840701
Pubmed	Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.	CXCR1 CXCR2	6.83e-06	3	53	2	31666007
Pubmed	CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.	CXCR1 CXCR2	6.83e-06	3	53	2	20089160
Pubmed	Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics.	CXCR1 CXCR2	6.83e-06	3	53	2	22242662
Pubmed	CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.	CXCR1 CXCR2	6.83e-06	3	53	2	17204468
Pubmed	Molecular evolution of the human interleukin-8 receptor gene cluster.	CXCR1 CXCR2	6.83e-06	3	53	2	1303245
Pubmed	Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey.	CXCR1 CXCR2	6.83e-06	3	53	2	34050991
Pubmed	Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.	CXCR1 CXCR2	6.83e-06	3	53	2	19151925
Pubmed	Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors.	CXCR1 CXCR2	6.83e-06	3	53	2	20630874
Pubmed	The CXCL8-CXCR1/2 pathways in cancer.	CXCR1 CXCR2	6.83e-06	3	53	2	27578214
Pubmed	Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program.	CXCR1 CXCR2	6.83e-06	3	53	2	24462138
Pubmed	Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers.	CXCR1 CXCR2	6.83e-06	3	53	2	19890050
Pubmed	Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.	CXCR1 CXCR2	6.83e-06	3	53	2	22325052
Pubmed	Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial.	CXCR1 CXCR2	6.83e-06	3	53	2	16679868
Pubmed	The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities.	CXCR1 CXCR2	6.83e-06	3	53	2	15946947
Pubmed	The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma.	CXCR1 CXCR2	6.83e-06	3	53	2	22626766
Pubmed	IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma.	CXCR1 CXCR2	6.83e-06	3	53	2	30086759
Pubmed	Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.	CXCR1 CXCR2	6.83e-06	3	53	2	8195702
Pubmed	The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.	CXCR1 CXCR2	6.83e-06	3	53	2	31573846
Pubmed	Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2.	CXCR1 CXCR2	6.83e-06	3	53	2	23912333
Pubmed	CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.	CXCR1 CXCR2	6.83e-06	3	53	2	15545821
Pubmed	Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts.	CXCR1 CXCR2	6.83e-06	3	53	2	16897191
Pubmed	Characterization of two high affinity human interleukin-8 receptors.	CXCR1 CXCR2	6.83e-06	3	53	2	1379593
Pubmed	Chemokine regulation of neutrophil function in surgical inflammation.	CXCR1 CXCR2	6.83e-06	3	53	2	10593335
Pubmed	IL-8 and its CXCR1 and CXCR2 receptors participate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis.	CXCR1 CXCR2	6.83e-06	3	53	2	15454487
Pubmed	Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.	CXCR1 CXCR2	6.83e-06	3	53	2	36086981
Pubmed	IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.	CXCR1 CXCR2	6.83e-06	3	53	2	24946112
Pubmed	IL-8, IL-8RA (CXCR1) and IL-8RB (CXCR2) expression in pilomatricoma.	CXCR1 CXCR2	6.83e-06	3	53	2	27151689
Pubmed	Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes.	CXCR1 CXCR2	6.83e-06	3	53	2	9260277
Interaction	CXCL5 interactions	VWC2L CXCR1 CXCR2	1.90e-05	27	39	3	int:CXCL5
Cytoband	11p15.4	OR52R1 OR52N4 OR52B6 OR51F1	7.44e-05	200	51	4	11p15.4
Cytoband	12p13.2	TAS2R30 TAS2R46	1.16e-03	45	51	2	12p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5H14 OR5H1	1.67e-03	54	51	2	chr3q11
Cytoband	Ensembl 112 genes in cytogenetic band chr13q33	ABHD13 CCDC168	1.73e-03	55	51	2	chr13q33
Cytoband	2q37.3	OR6B3 OR6B2	3.36e-03	77	51	2	2q37.3
Cytoband	2q35	CXCR1 CXCR2	3.53e-03	79	51	2	2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52R1 OR52N4 OR52B6 OR51F1	3.57e-03	564	51	4	chr11p15
Cytoband	1q44	OR1C1 OR14A16	6.72e-03	110	51	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	TAS2R8 TAS2R30 TAS2R46	7.15e-03	353	51	3	chr12p13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR1C1 OR14A16	8.99e-03	128	51	2	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	CXCR1 CXCR2	9.13e-03	129	51	2	chr2q35
GeneFamily	Taste 2 receptors	TAS2R8 TAS2R36 TAS2R45 TAS2R30 TAS2R46	2.87e-08	39	42	5	1162
GeneFamily	G protein-coupled receptors, Class A orphans	GPR4 GPR78 GPR152 GPR84	3.17e-05	78	42	4	262
GeneFamily	CD molecules\|C-X-C motif chemokine receptors	CXCR1 CXCR2	7.86e-05	6	42	2	1094
GeneFamily	Olfactory receptors, family 52	OR52R1 OR52N4 OR52B6	1.99e-04	49	42	3	165
GeneFamily	Olfactory receptors, family 1	OR1C1 OR1J4	3.89e-03	40	42	2	147
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	CXCR1 CXCR2	4.28e-03	42	42	2	602
GeneFamily	Olfactory receptors, family 6	OR6B3 OR6B2	6.25e-03	51	42	2	153
Drug	diaminocyclobut-3-ene-1,2-dione	CXCR1 CXCR2	1.47e-05	3	51	2	CID002781329
Drug	Ionophores	CXCR1 CXCR2	1.47e-05	3	51	2	ctd:D007476
Drug	5-methoxysalicylaldehyde	CXCR1 CXCR2	1.47e-05	3	51	2	CID000095695
Drug	DTTA	CXCR1 CXCR2	1.47e-05	3	51	2	CID000166909
Drug	dimethylcyclohexane	CXCR1 CXCR2	1.47e-05	3	51	2	CID000011549
Drug	nitroethylene	CXCR1 CXCR2	2.94e-05	4	51	2	CID000077197
Drug	deltorphin II, Ala(2)-	CXCR1 CXCR2	2.94e-05	4	51	2	ctd:C060209
Drug	titanium oxide (TiO	SLC34A1 CXCR1 CXCR2	2.98e-05	27	51	3	CID000061685
Drug	oleandrin	CXCR1 CXCR2	7.34e-05	6	51	2	ctd:C021065
Drug	M 129	CXCR1 CXCR2	7.34e-05	6	51	2	CID000192788
Drug	2-methoxy-6-methylaminopyridine	CXCR1 CXCR2	7.34e-05	6	51	2	CID007019167
Drug	antileukinate	CXCR1 CXCR2	7.34e-05	6	51	2	ctd:C118980
Drug	2-(4-isobutylphenyl)propionylmethanesulfonamide	CXCR1 CXCR2	1.03e-04	7	51	2	ctd:C490707
Disease	blood pressure, response to thiazide, response to beta blocker	OR5H14 OR5H1	5.65e-06	3	41	2	EFO_0004325, EFO_0007766, EFO_0007981
Disease	Malformations of Cortical Development	PIK3CA SLC1A1	1.70e-04	14	41	2	C1955869
Disease	Cortical Dysplasia	PIK3CA SLC1A1	1.70e-04	14	41	2	C0431380
Disease	Benign neoplasm of stomach	ATR PIK3CA	2.53e-04	17	41	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR PIK3CA	2.53e-04	17	41	2	C0496905
Disease	Carcinoma in situ of stomach	ATR PIK3CA	2.53e-04	17	41	2	C0154060
Disease	Stomach Carcinoma	ATR PIK3CA	3.89e-04	21	41	2	C0699791
Disease	breast cancer (implicated_via_orthology)	ATR PIK3CA	5.54e-04	25	41	2	DOID:1612 (implicated_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of ovary	ATR PIK3CA	7.47e-04	29	41	2	C0496920
Disease	Ovarian Carcinoma	ATR PIK3CA	7.99e-04	30	41	2	C0029925

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLVSLTRLCHVLGPF	URB2	1056	Q14146
CRISLLPLIVTFHLY	ABHD13	26	Q7L211
PKVYTTLPICILHIV	ADGB	1021	Q8N7X0
LPYACVLVLLGAHTA	APCDD1L	6	Q8NCL9
CVLISGLVLLAYFLP	CHRNE	251	Q04844
CIRLLILSYVGGLLH	OR5H14	141	A6NHG9
LVGPLCLVLVSYLHI	OR2A12	206	Q8NGT7
AHLTAILCAYGPVIV	OR10D4P	241	Q8NGN7
IPPSCHIIVANIYLL	OR52N4	271	Q8NGI2
PISHLYILVTCLGLS	MAGEA2	171	P43356
LLIIHGSYALIQLPT	DUOX2	1231	Q9NRD8
GCAVPSTVLLLLAYL	KCNK17	16	Q96T54
PCIVLSYILIIHSVL	OR51F1	221	A6NGY5
GSHICVILLFYVPAL	OR52B6	261	Q8NGF0
ILHLYKQGIPLCALI	PDCL3	116	Q9H2J4
ILGILHSCLNPLIYA	CXCR2	301	P25025
VLLLSLCVPYVIASG	MARCHF6	816	O60337
GFLPFLLLLVCHVLT	GPR152	201	Q8TDT2
LHAVGFVLPLAVLCL	GPR78	176	Q96P69
AIVLVCFAPYHVLLL	GPR4	231	P46093
LCLIALGRYLLIAHP	GPR84	111	Q9NQS5
HYCVTIPEILPKLLL	PIK3CA	556	P42336
VITLPLICILISYGH	OR1J4	206	Q8NGS1
CIRLLILSYVGGILH	OR5H1	141	A6NKK0
VLVLLPLEAATGYLH	SLC34A1	231	Q06495
SHICVILALYIPALF	OR52R1	246	Q8NGF1
IYLLPHILVYVLLGC	ATR	1526	Q13535
FALLEIVHCLIGIVP	HACD1	121	B0YJ81
EILGFLHSCLNPIIY	CXCR1	291	P25024
LAPLCLYVVVGVSLL	FZD3	376	Q9NPG1
ILESVLPCILHQLYI	CCDC168	3191	Q8NDH2
LTPLVILLGEYHAAL	SLC22A13	466	Q9Y226
LYIIHGPICAALLVN	CALCRL	291	Q16602
TGLAIHSIVILPLIY	SLC1A1	291	P43005
RYHVLVTPGLCLQLV	OR6B2	131	Q6IFH4
LALTPLVCILVSYGL	OR1C1	206	Q15619
HVLILLLSAVPISYL	PANX2	231	Q96RD6
YSICLPHLLVVLFLS	OR14A16	236	Q8NHC5
LYLFSVCHILLLVHP	SMG8	201	Q8ND04
VILLGPLLFLVCHLF	TAS2R30	131	P59541
VIVLGPLVFLVCHLV	TAS2R36	131	P0DTE0
VVLLGPLLFLACHLF	TAS2R45	131	P59539
VILLGPLLFLVCHLF	TAS2R46	131	P59540
ALPIPVICVTYEHLI	EPRS1	616	P07814
TGLLLIYPTSILHIL	TEX47	86	Q8TBZ9
GLLTCIIYALVIIHP	TDRD15	896	B5MCY1
RYHVLVTPGLCLQLV	OR6B3	131	Q8NGW1
VLVPVLYLLVCAAGL	SSTR5	41	P35346
LAICKLIHITIEPLY	THOC2	381	Q8NI27
HEACILLLVIPGLVT	VWC2L	6	B2RUY7
EIAAILYPLGHSLIL	TAS2R8	271	Q9NYW2
YLLLSVACFLHPVLV	TMEM72	96	A0PK05
HTIYLLPTVVICNLL	VPS13D	3176	Q5THJ4