Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstem cell factor receptor binding

SPRED1 SPRED2

8.56e-065192GO:0005173
GeneOntologyMolecularFunctionprotein serine/threonine kinase inhibitor activity

SPRED1 SPRED2

6.88e-0441192GO:0030291
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

KIT PDGFRB

1.72e-0365192GO:0004714
GeneOntologyMolecularFunctionkinase binding

PER1 PDGFRB JAKMIP2 SPRED1 SPRED2

1.75e-03969195GO:0019900
GeneOntologyMolecularFunctionprotein kinase inhibitor activity

SPRED1 SPRED2

2.66e-0381192GO:0004860
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

KIT PDGFRB

2.92e-0385192GO:0019199
GeneOntologyMolecularFunctionkinase inhibitor activity

SPRED1 SPRED2

2.99e-0386192GO:0019210
GeneOntologyMolecularFunctionphosphatase regulator activity

PPP1R2 ZEB2

5.10e-03113192GO:0019208
GeneOntologyBiologicalProcessregulation of lens fiber cell differentiation

SPRED1 ZEB2 SPRED2

6.67e-0810183GO:1902746
GeneOntologyBiologicalProcesssensory organ development

PHOX2B KIT PDGFRB SPRED1 ZEB2 CASZ1 SPRED2

1.53e-06730187GO:0007423
GeneOntologyBiologicalProcessmelanocyte migration

KIT ZEB2

2.16e-063182GO:0097324
GeneOntologyBiologicalProcesssensory system development

PHOX2B PDGFRB SPRED1 ZEB2 CASZ1 SPRED2

2.57e-06491186GO:0048880
GeneOntologyBiologicalProcesslens fiber cell differentiation

SPRED1 ZEB2 SPRED2

7.23e-0644183GO:0070306
GeneOntologyBiologicalProcessnegative regulation of lens fiber cell differentiation

SPRED1 SPRED2

1.08e-056182GO:1902747
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

SPRED1 ZEB2 FBN1 SPRED2

2.01e-05192184GO:0017015
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

SPRED1 ZEB2 FBN1 SPRED2

2.14e-05195184GO:1903844
GeneOntologyBiologicalProcesscamera-type eye development

PDGFRB SPRED1 ZEB2 CASZ1 SPRED2

2.52e-05426185GO:0043010
GeneOntologyBiologicalProcesseye development

PDGFRB SPRED1 ZEB2 CASZ1 SPRED2

4.46e-05480185GO:0001654
GeneOntologyBiologicalProcessvisual system development

PDGFRB SPRED1 ZEB2 CASZ1 SPRED2

4.59e-05483185GO:0150063
GeneOntologyBiologicalProcessregulation of MAPK cascade

PER1 KIT PDGFRB SPRED1 ZEB2 SPRED2

4.61e-05815186GO:0043408
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

5.83e-05850186GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

7.21e-05883186GO:0070848
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

SPRED1 ZEB2 FBN1 SPRED2

8.28e-05276184GO:0007179
GeneOntologyBiologicalProcesslens development in camera-type eye

SPRED1 ZEB2 SPRED2

9.34e-05103183GO:0002088
GeneOntologyBiologicalProcessMAPK cascade

PER1 KIT PDGFRB SPRED1 ZEB2 SPRED2

9.62e-05930186GO:0000165
GeneOntologyBiologicalProcesspositive regulation of DNA damage response, signal transduction by p53 class mediator

SPRED1 SPRED2

9.71e-0517182GO:0043517
GeneOntologyBiologicalProcessmesenchymal cell differentiation

PHOX2B SPRED1 ZEB2 SPRED2

1.09e-04296184GO:0048762
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

PPP1R2 KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

1.17e-041421187GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

PPP1R2 KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

1.19e-041423187GO:0051174
GeneOntologyBiologicalProcessregulation of protein kinase activity

KIT PDGFRB SPRED1 ZEB2 FBN1

1.40e-04611185GO:0045859
GeneOntologyBiologicalProcessregulation of protein modification process

PPP1R2 KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

1.57e-041488187GO:0031399
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

SPRED1 ZEB2 FBN1 SPRED2

1.77e-04336184GO:0071560
GeneOntologyBiologicalProcesspositive regulation of MAP kinase activity

KIT PDGFRB ZEB2

1.82e-04129183GO:0043406
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

SPRED1 ZEB2 FBN1 SPRED2

1.91e-04343184GO:0071559
GeneOntologyBiologicalProcessfibroblast activation

PDGFRB ZEB2

1.96e-0424182GO:0072537
GeneOntologyBiologicalProcessnegative regulation of peptidyl-threonine phosphorylation

SPRED1 SPRED2

1.96e-0424182GO:0010801
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

SPRED1 ZEB2 FBN1 SPRED2

2.00e-04347184GO:0090092
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

KIT PDGFRB ZEB2 FBN1

2.07e-04350184GO:0045860
GeneOntologyBiologicalProcessnegative regulation of transforming growth factor beta receptor signaling pathway

SPRED1 FBN1 SPRED2

2.22e-04138183GO:0030512
GeneOntologyBiologicalProcessregulation of kinase activity

KIT PDGFRB SPRED1 ZEB2 FBN1

2.40e-04686185GO:0043549
GeneOntologyBiologicalProcessmesenchyme development

PHOX2B SPRED1 ZEB2 SPRED2

2.61e-04372184GO:0060485
GeneOntologyBiologicalProcessregulation of protein phosphorylation

KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

2.84e-041133186GO:0001932
GeneOntologyBiologicalProcessmelanocyte differentiation

KIT ZEB2

2.88e-0429182GO:0030318
GeneOntologyBiologicalProcesspositive regulation of kinase activity

KIT PDGFRB ZEB2 FBN1

3.60e-04405184GO:0033674
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

3.64e-041186186GO:0007167
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

SPRED1 ZEB2 FBN1 SPRED2

3.84e-04412184GO:0090287
GeneOntologyBiologicalProcessregulation of protein deacetylation

SPRED1 SPRED2

3.97e-0434182GO:0090311
GeneOntologyBiologicalProcesscoronary vasculature morphogenesis

PDGFRB SPRED1

3.97e-0434182GO:0060977
GeneOntologyBiologicalProcesspositive regulation of signal transduction by p53 class mediator

SPRED1 SPRED2

3.97e-0434182GO:1901798
GeneOntologyBiologicalProcessnegative regulation of developmental process

PHOX2B KIT SPRED1 CASZ1 FBN1 SPRED2

4.24e-041220186GO:0051093
GeneOntologyBiologicalProcessregulation of phosphorylation

KIT PDGFRB SPRED1 ZEB2 FBN1 SPRED2

4.35e-041226186GO:0042325
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

SPRED1 ZEB2 FBN1 SPRED2

5.14e-04445184GO:0141091
GeneOntologyBiologicalProcessregulation of transferase activity

KIT PDGFRB SPRED1 ZEB2 FBN1

5.16e-04810185GO:0051338
GeneOntologyBiologicalProcesspigment cell differentiation

KIT ZEB2

5.50e-0440182GO:0050931
GeneOntologyBiologicalProcessregulation of DNA damage response, signal transduction by p53 class mediator

SPRED1 SPRED2

5.50e-0440182GO:0043516
GeneOntologyBiologicalProcesspositive regulation of Rho protein signal transduction

PDGFRB ARHGEF3

5.78e-0441182GO:0035025
GeneOntologyBiologicalProcesspositive regulation of intracellular signal transduction

KIT PDGFRB SPRED1 ZEB2 ARHGEF3 SPRED2

5.93e-041299186GO:1902533
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

KIT PDGFRB ZEB2

5.93e-04193183GO:0071902
GeneOntologyBiologicalProcessregulation of MAP kinase activity

KIT PDGFRB ZEB2

6.02e-04194183GO:0043405
GeneOntologyBiologicalProcessnegative regulation of smoothened signaling pathway

GPR161 SALL3

6.07e-0442182GO:0045879
GeneOntologyBiologicalProcesscentral nervous system neuron axonogenesis

PHOX2B ZEB2

6.36e-0443182GO:0021955
GeneOntologyBiologicalProcessnegative regulation of MAPK cascade

PER1 SPRED1 SPRED2

6.68e-04201183GO:0043409
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

SPRED1 ZEB2 FBN1 SPRED2

6.95e-04482184GO:0007178
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

PHOX2B SPRED1 CASZ1 FBN1 SPRED2

7.33e-04875185GO:0045596
GeneOntologyBiologicalProcesspositive regulation of transferase activity

KIT PDGFRB ZEB2 FBN1

7.39e-04490184GO:0051347
GeneOntologyBiologicalProcessprotein deacetylation

SPRED1 SPRED2

7.60e-0447182GO:0006476
GeneOntologyBiologicalProcessregulation of epithelial cell differentiation

SPRED1 ZEB2 SPRED2

8.34e-04217183GO:0030856
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

SPRED1 FBN1 SPRED2

8.45e-04218183GO:0090101
GeneOntologyBiologicalProcesstube development

KIT PDGFRB GPR161 SPRED1 ZEB2 FBN1

8.89e-041402186GO:0035295
GeneOntologyBiologicalProcessregulation of peptidyl-threonine phosphorylation

SPRED1 SPRED2

9.29e-0452182GO:0010799
GeneOntologyBiologicalProcessvascular associated smooth muscle cell differentiation

KIT PDGFRB

1.04e-0355182GO:0035886
GeneOntologyBiologicalProcessnegative regulation of epithelial to mesenchymal transition

SPRED1 SPRED2

1.08e-0356182GO:0010719
GeneOntologyBiologicalProcessdevelopmental pigmentation

KIT ZEB2

1.16e-0358182GO:0048066
GeneOntologyBiologicalProcessprotein deacylation

SPRED1 SPRED2

1.16e-0358182GO:0035601
GeneOntologyBiologicalProcessneural crest cell migration

PHOX2B ZEB2

1.32e-0362182GO:0001755
GeneOntologyBiologicalProcessameboidal-type cell migration

PHOX2B KIT SPRED1 ZEB2

1.36e-03577184GO:0001667
GeneOntologyBiologicalProcessmacromolecule deacylation

SPRED1 SPRED2

1.36e-0363182GO:0098732
GeneOntologyBiologicalProcessmesenchymal cell migration

PHOX2B ZEB2

1.40e-0364182GO:0090497
GeneOntologyBiologicalProcessnegative regulation of epithelial cell differentiation

SPRED1 SPRED2

1.63e-0369182GO:0030857
HumanPhenoSkin nodule

PHOX2B KIT PDGFRB SPRED1 ZEB2 FBN1

2.13e-0813296HP:0200036
HumanPhenoNeoplasm of the nervous system

PHOX2B KIT PDGFRB GPR161 SPRED1 CASZ1

2.23e-0719596HP:0004375
HumanPhenoPapule

PHOX2B KIT PDGFRB SPRED1 ZEB2 FBN1

3.37e-0720996HP:0200034
HumanPhenoNeoplasm of the central nervous system

PHOX2B PDGFRB GPR161 SPRED1 CASZ1

5.54e-0617895HP:0100006
HumanPhenoAbnormality of skin pigmentation

KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

5.60e-0656197HP:0001000
HumanPhenoLocalized skin lesion

PHOX2B KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

6.85e-0689798HP:0011355
HumanPhenoNeoplasm by anatomical site

PHOX2B KIT PDGFRB GPR161 SPRED1 ZEB2 CASZ1 SPRED2

1.16e-0595998HP:0011793
HumanPhenoAbnormality of pigmentation

KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

1.17e-0562597HP:0200045
HumanPhenoNeoplasm by histology

PHOX2B KIT PDGFRB SPRED1 ZEB2 CASZ1

1.20e-0538396HP:0011792
HumanPhenoSubcutaneous nodule

PHOX2B PDGFRB ZEB2 FBN1

1.33e-059594HP:0001482
HumanPhenoNeoplasm

PHOX2B KIT PDGFRB GPR161 SPRED1 ZEB2 CASZ1 SPRED2

1.45e-0598798HP:0002664
HumanPhenoMalignant neoplasm of the central nervous system

PHOX2B GPR161 SPRED1 CASZ1

1.57e-059994HP:0100836
HumanPhenoAbnormality iris morphology

PHOX2B KIT SPRED1 ZEB2 CASZ1 FBN1 SPRED2

2.07e-0568097HP:0000525
HumanPhenoPosteriorly rotated ears

PHOX2B SPRED1 ZEB2 CASZ1 FBN1 SPRED2

3.94e-0547096HP:0000358
HumanPhenoDownslanted palpebral fissures

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

5.44e-0549796HP:0000494
HumanPhenoPulmonic stenosis

SPRED1 ZEB2 FBN1 SPRED2

5.85e-0513894HP:0001642
HumanPhenoPointed chin

PDGFRB ZEB2 CASZ1 SPRED2

5.85e-0513894HP:0000307
HumanPhenoAbnormal bleeding

PHOX2B KIT PDGFRB ZEB2 FBN1 SPRED2

8.49e-0553796HP:0001892
HumanPhenoAbnormal pulmonary valve physiology

SPRED1 ZEB2 FBN1 SPRED2

1.12e-0416394HP:0031654
HumanPhenoMelanocytic nevus

ZEB2 FBN1 SPRED2

1.80e-046893HP:0000995
HumanPhenoLeukemia

KIT PDGFRB SPRED1 SPRED2

1.92e-0418794HP:0001909
HumanPhenoNeoplasm of the peripheral nervous system

PHOX2B KIT SPRED1

1.97e-047093HP:0100007
HumanPhenoSoft tissue neoplasm

PDGFRB SPRED1

2.14e-041392HP:0031459
HumanPhenoAbnormal uvea morphology

PHOX2B KIT SPRED1 ZEB2 CASZ1 FBN1 SPRED2

2.16e-0496597HP:0000553
HumanPhenoAbnormal eyelid morphology

PHOX2B KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

2.28e-04140898HP:0000492
HumanPhenoAbnormal pulmonary valve morphology

SPRED1 ZEB2 FBN1 SPRED2

2.39e-0419894HP:0001641
HumanPhenoAbnormality of coagulation

PHOX2B KIT PDGFRB ZEB2 FBN1 SPRED2

2.45e-0464796HP:0001928
HumanPhenoAbnormal anterior eye segment morphology

PHOX2B KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

2.86e-04145098HP:0004328
HumanPhenoAbnormality of the chin

PDGFRB ZEB2 CASZ1 FBN1 SPRED2

3.13e-0440995HP:0000306
HumanPhenoMyeloproliferative disorder

KIT PDGFRB

3.29e-041692HP:0005547
HumanPhenoNeuroepithelial neoplasm

PHOX2B SPRED1 CASZ1

4.43e-049293HP:0030063
HumanPhenoAbnormal hand morphology

KIT PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

4.60e-04108297HP:0005922
HumanPhenoNeurofibroma

KIT SPRED1

4.67e-041992HP:0001067
HumanPhenoAbnormality of the philtrum

KIT PDGFRB ZEB2 CASZ1 FBN1 SPRED2

4.70e-0472696HP:0000288
HumanPhenoNeuroectodermal neoplasm

PHOX2B SPRED1 CASZ1

4.72e-049493HP:0030061
HumanPhenoNervous tissue neoplasm

PHOX2B SPRED1 CASZ1

4.72e-049493HP:0030060
HumanPhenoAbnormality of the inner ear

PHOX2B PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

5.19e-04110297HP:0000359
HumanPhenoSlanting of the palpebral fissure

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

5.19e-0473996HP:0200006
HumanPhenoPtosis

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

5.81e-0475496HP:0000508
HumanPhenoAbnormality of globe location

PHOX2B PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

5.83e-04112297HP:0100886
HumanPhenoChiari malformation

SPRED1 ZEB2 FBN1

6.90e-0410793HP:0002308
HumanPhenoAbnormal nasal dorsum morphology

PDGFRB ZEB2 CASZ1 FBN1

7.02e-0426294HP:0011119
HumanPhenoEctopia pupillae

ZEB2 FBN1

7.51e-042492HP:0009918
HumanPhenoAbnormality of blood circulation

KIT PDGFRB ZEB2 FBN1 SPRED2

7.90e-0449895HP:0011028
HumanPhenoWide nasal bridge

KIT PDGFRB ZEB2 CASZ1 FBN1

8.67e-0450895HP:0000431
HumanPhenoXanthelasma

PDGFRB SPRED1

8.82e-042692HP:0001114
HumanPhenoAnterior bulging of the globe

PHOX2B PDGFRB FBN1 SPRED2

9.41e-0428394HP:0000644
HumanPhenoProptosis

PHOX2B PDGFRB FBN1 SPRED2

9.41e-0428394HP:0000520
HumanPhenoCyst of the eyelid

PDGFRB SPRED1

9.52e-042792HP:0010604
HumanPhenoNarrow nose

PDGFRB FBN1

1.02e-032892HP:0000460
HumanPhenoMitral valve prolapse

SPRED1 FBN1 SPRED2

1.04e-0312393HP:0001634
HumanPhenoMidface retrusion

PDGFRB CASZ1 FBN1 SPRED2

1.05e-0329194HP:0011800
HumanPhenoFibroma

KIT PDGFRB SPRED1

1.06e-0312493HP:0010614
HumanPhenoNodular changes affecting the eyelids

PDGFRB SPRED1

1.10e-032992HP:0010732
HumanPhenoFibrous tissue neoplasm

KIT PDGFRB SPRED1

1.11e-0312693HP:0012316
HumanPhenoAbnormality of globe location or size

PHOX2B PDGFRB SPRED1 ZEB2 CASZ1 FBN1 SPRED2

1.15e-03124697HP:0000489
HumanPhenoMyeloid leukemia

KIT SPRED2

1.26e-033192HP:0012324
HumanPhenoAbnormal pulmonary artery morphology

ZEB2 FBN1 SPRED2

1.30e-0313393HP:0030966
HumanPhenoAbnormality of the palpebral fissures

PHOX2B PDGFRB SPRED1 ZEB2 FBN1 SPRED2

1.37e-0388096HP:0008050
HumanPhenoAbnormal pupil morphology

PHOX2B ZEB2 FBN1

1.39e-0313693HP:0000615
HumanPhenoThick lower lip vermilion

ZEB2 FBN1 SPRED2

1.39e-0313693HP:0000179
HumanPhenoPectus excavatum

SPRED1 ZEB2 FBN1 SPRED2

1.55e-0332394HP:0000767
HumanPhenoReduced bone mineral density

KIT PDGFRB ZEB2 FBN1 SPRED2

1.58e-0357895HP:0004349
HumanPhenoAplasia/Hypoplasia of the abdominal wall musculature

FBN1 SPRED2

1.69e-033692HP:0010318
HumanPhenoShallow orbits

PDGFRB FBN1

1.69e-033692HP:0000586
HumanPhenoAbnormal heart valve morphology

SPRED1 ZEB2 CASZ1 FBN1 SPRED2

1.71e-0358895HP:0001654
HumanPhenoAbnormal mitral valve morphology

SPRED1 FBN1 SPRED2

1.71e-0314693HP:0031477
HumanPhenoVascular skin abnormality

KIT PDGFRB CASZ1 FBN1 SPRED2

1.77e-0359395HP:0011276
HumanPhenoAbnormal enteric ganglion morphology

PHOX2B KIT ZEB2

1.85e-0315093HP:0004362
HumanPhenoAganglionic megacolon

PHOX2B KIT ZEB2

1.85e-0315093HP:0002251
HumanPhenoMegacolon

PHOX2B KIT ZEB2

1.85e-0315093HP:6000852
HumanPhenoAbnormal autonomic nervous system morphology

PHOX2B KIT ZEB2

1.88e-0315193HP:0012331
HumanPhenoAbnormal enteric nervous system morphology

PHOX2B KIT ZEB2

1.88e-0315193HP:0025028
HumanPhenoAbnormal diaphysis morphology

PDGFRB SPRED1 ZEB2 FBN1

1.94e-0334394HP:0000940
HumanPhenoShort foot

PDGFRB CASZ1 FBN1

1.95e-0315393HP:0001773
HumanPhenoShort feet

PDGFRB CASZ1 FBN1

1.95e-0315393HP:0001766
HumanPhenoSmall feet

PDGFRB CASZ1 FBN1

1.95e-0315393HP:0001764
HumanPhenoCardiovascular calcification

PDGFRB FBN1

1.99e-033992HP:0011915
HumanPhenoAbnormal morphology of bony orbit of skull

PDGFRB FBN1

1.99e-033992HP:3000030
HumanPhenoXanthomatosis

PDGFRB SPRED1

1.99e-033992HP:0000991
HumanPhenoAbnormal location of ears

PHOX2B SPRED1 ZEB2 CASZ1 FBN1 SPRED2

2.02e-0394596HP:0000357
HumanPhenoAbdominal distention

PHOX2B ZEB2 FBN1

2.03e-0315593HP:0003270
HumanPhenoProminent lips

ZEB2 FBN1 SPRED2

2.07e-0315693HP:0000184
MousePhenoincreased mast cell number

KIT SPRED1 FBN1

3.92e-0712183MP:0000324
MousePhenoabnormal mast cell number

KIT SPRED1 FBN1

5.14e-0627183MP:0020203
MousePhenoabnormal neural crest cell morphology

PHOX2B KIT ZEB2

7.12e-0630183MP:0009845
MousePhenoabnormal multipotent stem cell morphology

PHOX2B KIT ZEB2

7.88e-0631183MP:0002400
MousePhenoabnormal neural crest morphology

PHOX2B KIT ZEB2

8.69e-0632183MP:0009846
MousePhenoabnormal neural crest cell migration

PHOX2B KIT ZEB2

1.05e-0534183MP:0002950
MousePhenoembryonic lethality during organogenesis, complete penetrance

PPP1R2 PHOX2B KIT GPR161 NCOA6 ZEB2 FBN1

1.50e-05700187MP:0011098
MousePhenoabnormal mast cell morphology

KIT SPRED1 FBN1

1.99e-0542183MP:0000359
MousePhenoabnormal pluripotent precursor cell morphology

PHOX2B KIT ZEB2

1.99e-0542183MP:0002399
MousePhenoabnormal neural crest cell physiology

PHOX2B KIT ZEB2

2.14e-0543183MP:0012745
MousePhenoembryonic lethality during organogenesis

PPP1R2 PHOX2B KIT GPR161 NCOA6 ZEB2 FBN1

6.40e-05876187MP:0006207
MousePhenodecreased neural crest cell number

PHOX2B ZEB2

1.21e-0413182MP:0009843
MousePhenoincreased mast cell degranulation

KIT SPRED1

1.41e-0414182MP:0008764
MousePhenocraniofacial phenotype

KIT PDGFRB GPR161 SPRED1 NCOA6 ZEB2 FBN1 SALL3

1.50e-041372188MP:0005382
MousePhenoabnormal craniofacial morphology

KIT PDGFRB GPR161 SPRED1 NCOA6 ZEB2 FBN1 SALL3

1.50e-041372188MP:0000428
MousePhenolethality throughout fetal growth and development

PHOX2B KIT PDGFRB NCOA6 CASZ1

1.75e-04435185MP:0006208
MousePhenoabnormal blood coagulation

KIT PDGFRB FBN1 ARHGEF3

2.15e-04240184MP:0002551
MousePhenoabnormal hemostasis

KIT PDGFRB FBN1 ARHGEF3

2.21e-04242184MP:0009676
MousePhenoabnormal skin morphology

KIT PDGFRB SPRED1 NCOA6 CASZ1 FBN1 SALL3 SPRED2

2.27e-041455188MP:0002060
MousePhenodecreased fetal cardiomyocyte proliferation

NCOA6 CASZ1

2.37e-0418182MP:0011395
MousePhenolethality throughout fetal growth and development, complete penetrance

PHOX2B KIT NCOA6 CASZ1

3.04e-04263184MP:0011099
MousePhenoembryonic lethality during organogenesis, incomplete penetrance

PHOX2B KIT NCOA6 FBN1

3.27e-04268184MP:0011108
MousePhenolimbs/digits/tail phenotype

KIT PDGFRB GPR161 SPRED1 NCOA6 FBN1 SPRED2

6.15e-041258187MP:0005371
MousePhenoabnormal enteric nervous system morphology

PHOX2B KIT

7.12e-0431182MP:0001044
MousePhenoabnormal mast cell degranulation

KIT SPRED1

8.57e-0434182MP:0008763
MousePhenoaneurysm

PDGFRB FBN1

9.09e-0435182MP:0003279
MousePhenoabnormal fetal cardiomyocyte morphology

NCOA6 CASZ1

9.09e-0435182MP:0008788
MousePhenodisorganized myocardium

PDGFRB NCOA6

1.19e-0340182MP:0002190
MousePhenodecreased litter size

PER1 KIT NCOA6 SPRED2

1.22e-03380184MP:0001935
MousePhenobelly spot

KIT GPR161

1.25e-0341182MP:0000373
MousePhenoimpaired wound healing

PDGFRB NCOA6

1.31e-0342182MP:0001792
MousePhenoabnormal respiratory function

PHOX2B KIT SPRED1 FBN1

1.46e-03399184MP:0002327
MousePhenoabnormal litter size

PER1 KIT NCOA6 SPRED2

1.46e-03399184MP:0001933
MousePhenoincreased megakaryocyte cell number

KIT SPRED2

1.50e-0345182MP:0008254
MousePhenodilated heart right ventricle

PDGFRB FBN1

1.57e-0346182MP:0002754
MousePhenoprenatal lethality prior to heart atrial septation, incomplete penetrance

PHOX2B KIT NCOA6 FBN1

1.61e-03410184MP:0031660
MousePhenoembryonic lethality, incomplete penetrance

PHOX2B KIT NCOA6 FBN1

1.61e-03410184MP:0011102
MousePhenoincreased mean platelet volume

KIT FBN1 ARHGEF3

1.63e-03186183MP:0002599
MousePhenoabnormal exocytosis

KIT SPRED1

1.71e-0348182MP:0020848
MousePhenoincreased tumor growth/size

KIT LAYN

1.71e-0348182MP:0003721
MousePhenoabnormal fetal cardiomyocyte proliferation

NCOA6 CASZ1

1.71e-0348182MP:0003567
MousePhenodilated heart atrium

PDGFRB FBN1

1.78e-0349182MP:0003140
MousePhenowhite spotting

KIT GPR161

1.85e-0350182MP:0002938
MousePhenoabnormal airway responsiveness

KIT SPRED1

1.92e-0351182MP:0002334
MousePhenoabnormal bronchial provocation

KIT SPRED1

2.00e-0352182MP:0002330
MousePhenoabnormal lung volume

PHOX2B FBN1

2.23e-0355182MP:0001942
MousePhenoabnormal fetal cardiomyocyte physiology

NCOA6 CASZ1

2.23e-0355182MP:0011390
MousePhenoabnormal neuron number

PHOX2B KIT PDGFRB NCOA6

2.38e-03456184MP:0008946
MousePhenoabnormal embryonic hematopoiesis

PDGFRB NCOA6

2.48e-0358182MP:0003396
MousePhenoabnormal skin appearance

KIT PDGFRB NCOA6 FBN1

2.71e-03473184MP:0009931
MousePhenoabnormal heart size

PDGFRB SPRED1 NCOA6 CASZ1 FBN1 SALL3

2.73e-031180186MP:0005406
MousePhenoabnormal fibroblast apoptosis

PDGFRB NCOA6

2.83e-0362182MP:0013500
MousePhenoabnormal cardiac muscle tissue morphology

PDGFRB NCOA6 CASZ1 FBN1

3.06e-03489184MP:0010630
MousePhenoblood vessel congestion

PHOX2B CASZ1

3.10e-0365182MP:0000255
MousePhenoabnormal platelet volume

KIT FBN1 ARHGEF3

3.18e-03235183MP:0002586
MousePhenoabnormal fluid regulation

PDGFRB NCOA6 CASZ1 FBN1 SALL3

3.20e-03826185MP:0001784
MousePhenoabnormal myocardium compact layer morphology

NCOA6 CASZ1

3.30e-0367182MP:0004056
MousePhenoabnormal mast cell physiology

KIT SPRED1

3.30e-0367182MP:0002423
MousePhenopallor

KIT PDGFRB NCOA6

3.33e-03239183MP:0003717
MousePhenoabnormal cell migration

PHOX2B KIT PDGFRB ZEB2

3.34e-03501184MP:0003091
MousePhenoabnormal vascular permeability

KIT PDGFRB

3.39e-0368182MP:0001619
MousePhenodilated vasculature

NCOA6 FBN1

3.59e-0370182MP:0004938
MousePhenoventricle myocardium hypoplasia

NCOA6 CASZ1

3.69e-0371182MP:0010502
MousePhenoabnormal nervous system development

PHOX2B KIT GPR161 SPRED1 NCOA6 ZEB2

3.76e-031257186MP:0003861
DomainKBD

SPRED1 SPRED2

2.94e-063192PS51488
DomainKBD

SPRED1 SPRED2

2.94e-063192IPR023337
DomainTyr_kinase_CSF1/PDGF_rcpt

KIT PDGFRB

1.47e-056192IPR016243
DomainSPR

SPRED1 SPRED2

2.05e-057192PS51227
DomainSprouty

SPRED1 SPRED2

2.05e-057192IPR007875
DomainSprouty

SPRED1 SPRED2

2.05e-057192PF05210
DomainRECEPTOR_TYR_KIN_III

KIT PDGFRB

2.74e-058192PS00240
DomainTyr_kinase_rcpt_3_CS

KIT PDGFRB

2.74e-058192IPR001824
DomainWH1

SPRED1 SPRED2

5.36e-0511192SM00461
DomainWH1

SPRED1 SPRED2

5.36e-0511192PF00568
DomainWH1/EVH1_dom

SPRED1 SPRED2

5.36e-0511192IPR000697
DomainWH1

SPRED1 SPRED2

7.60e-0513192PS50229
Domain-

PLEKHH1 SPRED1 ARHGEF3 SPRED2

5.71e-043911942.30.29.30
DomainPH_dom-like

PLEKHH1 SPRED1 ARHGEF3 SPRED2

7.88e-04426194IPR011993
DomainTyrKc

KIT PDGFRB

3.56e-0388192SM00219
DomainTyr_kinase_cat_dom

KIT PDGFRB

3.56e-0388192IPR020635
DomainPROTEIN_KINASE_TYR

KIT PDGFRB

4.31e-0397192PS00109
DomainTyr_kinase_AS

KIT PDGFRB

4.31e-0397192IPR008266
DomainPkinase_Tyr

KIT PDGFRB

7.50e-03129192PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

KIT PDGFRB

8.54e-03138192IPR001245
DomainImmunoglobulin

KIT PDGFRB

1.57e-02190192IPR013151
Domainig

KIT PDGFRB

1.57e-02190192PF00047
PathwayWP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA

KIT PDGFRB SPRED2

1.35e-0620163M39381
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1

SPRED1 SPRED2

1.81e-056162M47932
PathwayREACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS

SPRED1 SPRED2

2.53e-057162M29717
PathwayPID_KIT_PATHWAY

KIT SPRED1 SPRED2

2.56e-0552163M231
PathwayWP_KIT_RECEPTOR_SIGNALING_PATHWAY

KIT SPRED1 SPRED2

6.54e-0571163MM15947
PathwayREACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING

SPRED1 SPRED2

9.35e-0513162M27540
PathwayREACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING

SPRED1 SPRED2

9.35e-0513162MM15262
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

KIT PDGFRB

3.57e-0425162M47934
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

KIT PDGFRB SPRED1 SPRED2

3.73e-04318164MM15278
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

KIT PDGFRB SPRED1 SPRED2

4.15e-04327164M27565
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

NCOA6 BOD1L1

1.01e-0342162M48018
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

KIT PDGFRB SPRED1 SPRED2

1.04e-03418164MM15587
PathwayPID_INTEGRIN3_PATHWAY

PDGFRB FBN1

1.06e-0343162M53
PathwayREACTOME_SIGNALING_BY_FGFR1

SPRED1 SPRED2

1.43e-0350162MM15255
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

KIT PDGFRB SPRED1 SPRED2

1.54e-03464164M27547
PathwayREACTOME_SIGNALING_BY_FGFR1

SPRED1 SPRED2

1.55e-0352162M27530
PathwayWP_MARKERS_OF_KIDNEY_CELL_LINEAGE

KIT PDGFRB

1.99e-0359162M46460
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

ZEB2 FBN1

1.99e-0359162M39886
PathwayREACTOME_REGULATION_OF_RAS_BY_GAPS

SPRED1 SPRED2

2.48e-0366162MM15261
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

KIT PDGFRB SPRED1 SPRED2

2.54e-03532164M27870
PathwayREACTOME_REGULATION_OF_RAS_BY_GAPS

SPRED1 SPRED2

2.63e-0368162M27539
PathwayREACTOME_CIRCADIAN_CLOCK

PER1 NCOA6

2.79e-0370162M938
PathwayREACTOME_SIGNALING_BY_FGFR

SPRED1 SPRED2

3.36e-0377162MM14722
PathwayREACTOME_ONCOGENIC_MAPK_SIGNALING

SPRED1 SPRED2

3.80e-0382162M27626
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_ABERRANT_PI3K_IN_CANCER

KIT PDGFRB

3.90e-0383162M27163
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY

KIT PDGFRB

3.90e-0383162M47961
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY

KIT PDGFRB

4.47e-0389162M47963
PathwayREACTOME_SIGNALING_BY_FGFR

SPRED1 SPRED2

4.47e-0389162M1090
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY

KIT PDGFRB

4.76e-0392162M47927
PathwayWP_HIPPO_SIGNALING_REGULATION

KIT PDGFRB

5.39e-0398162M39830
Pubmed

Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.

KIT SPRED1 SPRED2

5.53e-10419312646235
Pubmed

Spred is a Sprouty-related suppressor of Ras signalling.

SPRED1 SPRED2

2.83e-07219211493923
Pubmed

Association of Piebaldism, multiple café-au-lait macules, and intertriginous freckling: clinical evidence of a common pathway between KIT and sprouty-related, ena/vasodilator-stimulated phosphoprotein homology-1 domain containing protein 1 (SPRED1).

KIT SPRED1

2.83e-07219223016555
Pubmed

SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.

SPRED1 SPRED2

2.83e-07219225690936
Pubmed

Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.

SPRED1 SPRED2

2.83e-07219216652141
Pubmed

Expression of ligand-activated KIT and platelet-derived growth factor receptor beta tyrosine kinase receptors in synovial sarcoma.

KIT PDGFRB

2.83e-07219214871970
Pubmed

Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.

SPRED1 SPRED2

2.83e-07219215465815
Pubmed

Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas.

KIT PDGFRB

2.83e-07219219280218
Pubmed

mRNA expression of platelet-derived growth factor receptor-beta and C-KIT: correlation with pathologic response to cetuximab-based chemoradiotherapy in patients with rectal cancer.

KIT PDGFRB

2.83e-07219219028276
Pubmed

The role of mast cells in the development of skin fibrosis in tight-skin mutant mice.

KIT FBN1

2.83e-0721927704626
Pubmed

ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways.

KIT PDGFRB

2.83e-07219220197394
Pubmed

Distinct requirements for the Sprouty domain for functional activity of Spred proteins.

SPRED1 SPRED2

2.83e-07219215683364
Pubmed

Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.

PHOX2B CASZ1 SALL3

5.56e-073019335320729
Pubmed

Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.

KIT ZEB2 SALL3

6.79e-073219316516881
Pubmed

Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids.

SPRED1 SPRED2

8.48e-07319221364986
Pubmed

Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas.

KIT PDGFRB

8.48e-07319217298867
Pubmed

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

SPRED1 SPRED2

8.48e-07319229706577
Pubmed

Expression and subcellular localization of Spred proteins in mouse and human tissues.

SPRED1 SPRED2

8.48e-07319215580519
Pubmed

Expression of c-kit and platelet-derived growth factor receptors in ovarian granulosa cell tumors.

KIT PDGFRB

8.48e-07319218492696
Pubmed

Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers.

KIT PDGFRB

8.48e-07319215791568
Pubmed

The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.

SPRED1 SPRED2

8.48e-07319215184877
Pubmed

Next-Generation Sequencing and In Silico Analysis Facilitate Prolonged Response to Pazopanib in a Patient With Metastatic Urothelial Carcinoma of the Renal Pelvis.

KIT PDGFRB

8.48e-07319226483058
Pubmed

Expression and molecular analysis of c-kit and PDGFRs in Kaposi's sarcoma of different stages and epidemiological settings.

KIT PDGFRB

8.48e-07319219302534
Pubmed

Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors.

KIT PDGFRB

1.70e-06419219636022
Pubmed

Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer: a working hypothesis.

SPRED1 SPRED2

1.70e-06419226075267
Pubmed

A severe form of Noonan syndrome and autosomal dominant café-au-lait spots - evidence for different genetic origins.

SPRED1 SPRED2

1.70e-06419219120036
Pubmed

High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib.

KIT PDGFRB

1.70e-06419214745431
Pubmed

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.

SPRED1 SPRED2

2.82e-06519220736167
Pubmed

The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.

SPRED1 SPRED2

4.24e-06619231923414
Pubmed

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

SPRED1 SPRED2

4.24e-06619229501879
Pubmed

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.

KIT ZEB2

4.24e-06619221355089
Pubmed

Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth.

SPRED1 SPRED2

4.24e-06619238391903
Pubmed

Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.

PDGFRB FBN1

4.24e-0661927873879
Pubmed

Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.

KIT SPRED2

4.24e-06619214981116
Pubmed

Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.

SPRED1 SPRED2

4.24e-06619225576668
Pubmed

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

PPP1R2 KIT ARHGEF3 SALL3

4.41e-0620719426238476
Pubmed

Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut.

KIT PDGFRB

7.90e-06819218194151
Pubmed

Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.

SPRED1 SPRED2

7.90e-06819217438136
Pubmed

PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny.

KIT PDGFRB

7.90e-06819235858557
Pubmed

Abl family kinases regulate endothelial barrier function in vitro and in mice.

KIT PDGFRB

7.90e-06819224367707
Pubmed

A high-resolution molecular atlas of the fetal mouse lower urogenital tract.

KIT PDGFRB ZEB2

9.10e-067519321905163
Pubmed

CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.

KIT PDGFRB

1.02e-05919212177062
Pubmed

Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages.

KIT PDGFRB

1.27e-051019231185811
Pubmed

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

SPRED1 SPRED2

1.86e-051219217974561
Pubmed

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.

PHOX2B FBN1

1.86e-051219236779913
Pubmed

Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages.

KIT PDGFRB

2.20e-051319215857912
Pubmed

Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha.

GPR161 FBN1

2.56e-05141921912584
Pubmed

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.

PHOX2B ZEB2

2.56e-051419227370713
Pubmed

Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation.

KIT PDGFRB

2.56e-051419223789091
Pubmed

FGFR2 mutation in 46,XY sex reversal with craniosynostosis.

SPRED1 SPRED2

2.56e-051419226362256
Pubmed

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.

PHOX2B KIT

3.38e-051619217699610
Pubmed

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.

KIT PDGFRB

3.38e-051619210022833
Pubmed

Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.

JAKMIP2 IK

3.83e-051719219845895
Pubmed

Hirschsprung Disease Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

PHOX2B ZEB2

4.30e-051819220301612
Pubmed

Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception.

PHOX2B PER1

4.30e-051819215741322
Pubmed

Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.

PHOX2B KIT

4.30e-051819216790476
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PLEKHH1 PDGFRB SPRED1 ZEB2 FBN1 SPRED2

4.51e-05128519635914814
Pubmed

Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.

KIT PDGFRB

4.81e-051919228111199
Pubmed

Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia.

PHOX2B KIT

4.81e-051919217507395
Pubmed

Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins.

PHOX2B ZEB2

4.81e-051919229196262
Pubmed

Mesenchymal cells are required for functional development of thymic epithelial cells.

KIT PDGFRB

5.90e-052119217625108
Pubmed

Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes.

SPRED1 SPRED2

5.90e-052119232452519
Pubmed

Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.

KIT PDGFRB

6.49e-052219222387002
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

NCOA6 BOD1L1

6.49e-052219226886794
Pubmed

Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

SPRED1 SPRED2

7.10e-052319220934536
Pubmed

Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration.

KIT PDGFRB

7.10e-052319223946446
Pubmed

Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.

KIT PDGFRB

7.75e-052419230348676
Pubmed

Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.

PHOX2B ZEB2

7.75e-052419217131407
Pubmed

Specification of CNS macrophage subsets occurs postnatally in defined niches.

KIT PDGFRB

9.84e-052719235444273
Pubmed

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.

ZEB2 SALL3

9.84e-052719231257105
Pubmed

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

KIT PDGFRB

1.06e-042819218593464
Pubmed

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.

PDGFRB ZEB2

1.30e-043119236445780
Pubmed

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

KIT PDGFRB

1.39e-04321927542761
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SPRED1 BOD1L1 ARHGEF3 SALL3 IK

2.35e-04108419511544199
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

KIT PDGFRB

3.01e-044719219167335
Pubmed

Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development.

PDGFRB ZEB2

3.01e-044719239001875
Pubmed

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.

PHOX2B KIT

3.14e-044819235905011
Pubmed

Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.

PHOX2B ARHGEF3

3.14e-044819216632597
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

NCOA6 BOD1L1

3.41e-045019237974198
Pubmed

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

PDGFRB FBN1

3.69e-045219230389913
Pubmed

Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.

KIT PDGFRB

3.69e-04521928288218
Pubmed

Genome-wide atlas of gene expression in the adult mouse brain.

PHOX2B KIT

3.98e-045419217151600
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

NCOA6 CASZ1 IK

4.00e-0426819333640491
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

NCOA6 BOD1L1 IK

4.69e-0428319330585729
CytobandEnsembl 112 genes in cytogenetic band chr5q32

PDGFRB JAKMIP2

5.03e-0480192chr5q32
GeneFamilyReceptor Tyrosine Kinases|CD molecules

KIT PDGFRB

3.11e-0440122321
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R2 SPRED1

6.16e-03181122694
GeneFamilyImmunoglobulin like domain containing

KIT PDGFRB

6.97e-03193122594
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB2 CASZ1 SALL3

1.05e-0271812328
CoexpressionGSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_FETAL_UP

KIT PDGFRB SPRED1 ZEB2

1.17e-05200194M4570
CoexpressionDELACROIX_RAR_BOUND_ES

KIT PDGFRB SPRED1 ZEB2 SPRED2

1.63e-05465195M2466
CoexpressionLIU_PROSTATE_CANCER_DN

KIT GPR161 FBN1 SALL3 LAYN

2.16e-05493195M19391
CoexpressionDELACROIX_RAR_BOUND_ES

KIT PDGFRB SPRED1 ZEB2 SPRED2

2.16e-05493195MM1079
CoexpressionGRESHOCK_CANCER_COPY_NUMBER_UP

PHOX2B PER1 KIT PDGFRB

7.58e-05323194M9150
CoexpressionBRAUNE_GEIST_20_GENE_NOTCH_SIG_BREAST_CANCER

KIT PDGFRB

9.39e-0520192M48357
CoexpressionMEBARKI_HCC_PROGENITOR_WNT_UP_BLOCKED_BY_FZD8CRD

FBN1 ARHGEF3 LAYN

9.70e-05125193M38988
CoexpressionMURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL

PDGFRB SPRED1 ZEB2 FBN1 SPRED2

1.00e-04681195M39175
CoexpressionBROWNE_HCMV_INFECTION_24HR_DN

KIT PDGFRB FBN1

1.51e-04145193M14098
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPERIC

PER1 PDGFRB SPRED1 FBN1 LAYN

2.07e-04795195M39050
CoexpressionRODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN

PLEKHH1 SPRED1 ZEB2 FBN1 ARHGEF3

2.22e-04807195M16651
CoexpressionBUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP

PER1 GPR161 NCOA6 ZEB2 ARHGEF3

2.42e-04822195M6782
CoexpressionGSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_DN

PDGFRB ARHGEF3 SPRED2

2.58e-04174193M6881
CoexpressionGSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN

PDGFRB ARHGEF3 SPRED2

2.85e-04180193M6878
CoexpressionKYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP

PPP1R2 KIT

3.09e-0436192M2047
CoexpressionGSE2770_IL12_ACT_VS_ACT_CD4_TCELL_2H_UP

PPP1R2 JAKMIP2 ARHGEF3

3.49e-04193193M6130
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

PER1 KIT ZEB2 ARHGEF3 SALL3

3.65e-04899195M2242
CoexpressionGSE13229_MATURE_VS_INTMATURE_NKCELL_DN

ZEB2 ARHGEF3 IK

3.76e-04198193M3216
CoexpressionGSE22886_TH1_VS_TH2_12H_ACT_UP

PDGFRB ZEB2 SPRED2

3.82e-04199193M4507
CoexpressionGSE22229_UNTREATED_VS_IMMUNOSUPP_THERAPY_RENAL_TRANSPLANT_PATIENT_PBMC_UP

GPR161 SPRED1 SPRED2

3.88e-04200193M7478
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_DN

PER1 PLEKHH1 ZEB2

3.88e-04200193M7019
CoexpressionGSE2770_IL4_ACT_VS_ACT_CD4_TCELL_2H_DN

PER1 JAKMIP2 ARHGEF3

3.88e-04200193M6095
CoexpressionGSE4748_CTRL_VS_LPS_STIM_DC_3H_UP

SPRED1 FBN1 SPRED2

3.88e-04200193M6480
CoexpressionGSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_DN

PER1 PLEKHH1 ARHGEF3

3.88e-04200193M7822
CoexpressionGSE20366_TREG_VS_NAIVE_CD4_TCELL_DEC205_CONVERSION_DN

PHOX2B KIT NCOA6

3.88e-04200193M4334
CoexpressionMEBARKI_HCC_PROGENITOR_WNT_UP

FBN1 ARHGEF3 LAYN

3.99e-04202193M38982
CoexpressionTURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN

PER1 KIT SPRED1

4.22e-04206193M14134
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

PER1 KIT ZEB2 ARHGEF3 SALL3

4.27e-04930195MM893
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

KIT ARHGEF3 SALL3 SPRED2

4.89e-04526194M2520
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

PDGFRB FBN1

5.97e-0450192M1259
CoexpressionZHOU_TNF_SIGNALING_4HR

KIT FBN1

5.97e-0450192M1520
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

PDGFRB FBN1

6.46e-0452192MM1118
CoexpressionBENPORATH_SUZ12_TARGETS

PHOX2B ZEB2 CASZ1 FBN1 LAYN

6.96e-041035195M9898
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

KIT ARHGEF3 SALL3 SPRED2

7.24e-04584194MM1080
CoexpressionFLETCHER_PBMC_BCG_10W_INFANT_BCG_STIMULATED_VS_UNSTIMULATED_10W_DN

PDGFRB SPRED1 ZEB2

7.95e-04256193M41152
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

PDGFRB ZEB2 FBN1 LAYN

2.23e-06107194gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k3_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_500_k-means-cluster#4

PLEKHH1 KIT JAKMIP2

1.76e-04124193Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_500_K4
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

PDGFRB FBN1 LAYN

1.80e-04125193gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k4_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#2_top-relative-expression-ranked_500

PDGFRB ZEB2 FBN1

2.02e-04130193gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k2_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_100

PDGFRB FBN1

2.63e-0427192gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_100
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_200

PDGFRB ZEB2 FBN1

2.90e-04147193gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_200
CoexpressionAtlaskidney_adult_RenCorpuscGlomer_k-means-cluster#4_top-relative-expression-ranked_1000

PDGFRB ZEB2 LAYN

2.96e-04148193gudmap_kidney_adult_RenCorpuscGlomer_k4_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#2_top-relative-expression-ranked_1000

PPP1R2 CASZ1 FBN1 SPRED2

3.13e-04379194gudmap_developingLowerUrinaryTract_P1_bladder_B_1000_k2
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_500

PDGFRB ZEB2 FBN1

3.46e-04156193gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_500
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_1000

PHOX2B KIT PDGFRB JAKMIP2 FBN1

3.78e-04734195gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_500

PDGFRB ZEB2 FBN1

4.07e-04165193gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k2_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

PDGFRB FBN1 LAYN

4.29e-04168193gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k4_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500

PHOX2B JAKMIP2 ZEB2 SPRED2

4.46e-04416194gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

PDGFRB SPRED1 ZEB2 SALL3 SPRED2

4.68e-04769195gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasdev gonad_e12.5_F_DevVasOvary_Flk_k-means-cluster#3_top-relative-expression-ranked_1000

KIT SPRED2

4.69e-0436192gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_500

PPP1R2 PHOX2B KIT ZEB2

4.70e-04422194DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

KIT PDGFRB ZEB2 FBN1 LAYN

4.79e-04773195gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

PDGFRB SPRED1 ZEB2 FBN1 LAYN

4.91e-04777195gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#4_top-relative-expression-ranked_100

PDGFRB FBN1

4.96e-0437192gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k4_100
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#4_top-relative-expression-ranked_500

PDGFRB ZEB2 FBN1

5.42e-04182193gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k4_500
CoexpressionAtlasdev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_1000

PPP1R2 KIT ARHGEF3 SPRED2 LAYN

6.17e-04817195gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

PHOX2B PDGFRB JAKMIP2 ZEB2 SPRED2

6.21e-04818195gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

PDGFRB ZEB2 FBN1

6.24e-04191193gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k4_1000
CoexpressionAtlasdev gonad_e13.5_M_DevVasTestis_Flk_top-relative-expression-ranked_1000

PPP1R2 KIT ZEB2 ARHGEF3 LAYN

7.24e-04846195gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_1000
CoexpressionAtlasJC_fibro_top-relative-expression-ranked_500_k-means-cluster#3

PDGFRB FBN1 LAYN

7.77e-04206193JC_fibro_500_K3
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500

PDGFRB ZEB2 FBN1

7.88e-04207193gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlaskidney_adult_Mesangium_Meis_top-relative-expression-ranked_1000

PDGFRB ZEB2 FBN1 SPRED2 LAYN

8.30e-04872195gudmap_kidney_adult_Mesangium_Meis_1000
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_1000

PHOX2B KIT JAKMIP2

8.33e-04211193gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k1_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_500

PDGFRB FBN1

1.06e-0354192gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k2_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_200

PDGFRB FBN1

1.26e-0359192gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k2_200
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

PDGFRB NCOA6 FBN1 IK

8.76e-07178194edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellPSB-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT PDGFRB JAKMIP2 ZEB2

8.76e-0717819445bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDGFRB ZEB2 FBN1 LAYN

1.34e-061981940a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDGFRB ZEB2 FBN1 LAYN

1.39e-0620019444a68bacdb3d5bf563bd35952176995850933a81
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

KIT JAKMIP2 ZEB2 ARHGEF3

1.39e-0620019404699d1149a143b96d6f292c0d70c4d3e6dfc611
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDGFRB ZEB2 FBN1 LAYN

1.39e-06200194dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 ARHGEF3 SALL3

2.58e-0513719385b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KIT GPR161 FBN1

2.58e-051371936d90da42dcc06aa895f920218055068f3c76d57d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 ARHGEF3 SALL3

2.87e-051421935b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIT CASZ1 SALL3

3.06e-051451939964d6d3769be2f35d86268fe044cecd1d5a1616
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_atypical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB GPR161 LAYN

3.25e-05148193b7b5521162effc1024e7c399f690cd86d0b2f750
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIT JAKMIP2 ZEB2

3.45e-05151193f5ae450e3daa10540ca8437d05efe2d86ac70960
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

PPP1R2 FBN1 ARHGEF3

4.33e-05163193f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

PPP1R2 FBN1 LAYN

4.66e-0516719397d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAKMIP2 ARHGEF3 LAYN

4.74e-051681932765d98f0b7f6861d662937535e051d41dba3500
ToppCellcontrol-Myeloid-Mast_cell|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KIT JAKMIP2 ZEB2

5.09e-05172193c1c99e6732234a6649a79610e99390db0c8f19b0
ToppCellNS-control-d_0-4-Myeloid-Mast_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KIT JAKMIP2 ZEB2

5.26e-051741932d1f5c17b1551f32f49618ec1bf68eafbfd02ace
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIT ZEB2 CASZ1

5.35e-05175193282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

5.35e-051751931b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAKMIP2 ZEB2 ARHGEF3

5.45e-051761936b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCellCOVID-19-lung-MAST|COVID-19 / Disease (COVID-19 only), tissue and cell type

KIT JAKMIP2 ZEB2

5.45e-05176193473c45a381ca109207d66ed1635668b391ea0e1f
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

PDGFRB ZEB2 FBN1

5.63e-05178193142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.02e-05182193af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.02e-05182193b7d532feb73167e05475855061b35a209583f44c
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.11e-051831935cfcd589a480e67654d3d94e71916f122150db10
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.11e-05183193c3ea8d3b916ffcaca3156e0d77a952724554c4ab
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.11e-0518319381003ddc24164959dd41bb12fcac72638789b8f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB CASZ1 ARHGEF3

6.11e-051831933c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB JAKMIP2 ARHGEF3

6.11e-05183193612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB CASZ1 ARHGEF3

6.11e-051831939c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.21e-05184193fea4fe648e9749177d0783443dc26a7df5807883
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.21e-0518419396a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.21e-05184193780eb72da43527f0c72effac3423ec7384f05f20
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB CASZ1 ARHGEF3

6.21e-051841937294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.21e-05184193e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-051851933cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-0518519300258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-05185193a94694e226856bc5b168464f52d76004145717a5
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-051851938433a337625ff8398520e223ef92bf9bb0beb14c
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-05185193049d793d043d5d434f143025de49dd210d18756c
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.31e-0518519363200c42565eea596f9b00728e70e544b8d50a7f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 ARHGEF3 SALL3

6.42e-05186193d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

PDGFRB GPR161 FBN1

6.42e-051861931e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCell(0)_MSCs-(00)_Lepr-MSC|World / Cell class and subclass of bone marrow stroma cells in homeostatis

PDGFRB ZEB2 FBN1

6.42e-05186193f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell(0)_MSCs|World / Cell class and subclass of bone marrow stroma cells in homeostatis

PDGFRB ZEB2 FBN1

6.42e-05186193a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KIT PDGFRB ZEB2

6.42e-05186193c984e5729958237b101df96d1c89a236faacded6
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PDGFRB ZEB2 FBN1

6.42e-05186193cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

PDGFRB NCOA6 FBN1

6.62e-0518819314bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB SPRED1 LAYN

6.62e-05188193da862ea3c74f42d0dbae38b09211a45c593d477e
ToppCell-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

KIT PDGFRB FBN1

6.62e-05188193038f48e8daaeb72716e975d22a6b004a90654960
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB SPRED1 LAYN

6.62e-05188193b82a7667ef74a05e8bc744f6c090a7cc7b8efe32
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB SPRED1 LAYN

6.62e-0518819319672d284fe89c9c3c7697514ca1f659329c34f4
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

CASZ1 ARHGEF3 SALL3

6.62e-05188193df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KIT PDGFRB ZEB2

6.73e-051891939c2492c38f27e4c699b40680652e4c64911cce52
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.73e-0518919371397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 ARHGEF3 SALL3

6.73e-051891937eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP1R2 JAKMIP2 LAYN

6.73e-051891935c85656f555d91ecc9540faa67717694a4aef92f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.73e-051891934eea4759520c312bd17a681034d8074e47093d2b
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.73e-0518919329287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.73e-051891937150dad9a92a715487c2d8130fa01b752ea69663
ToppCellE18.5-samps-Mesenchymal|E18.5-samps / Age Group, Lineage, Cell class and subclass

PDGFRB ZEB2 FBN1

6.73e-051891930c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.73e-05189193c734e5693808a0333139e87bd5be2597a9252afe
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.73e-051891936e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R2 FBN1 LAYN

6.83e-05190193876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.83e-0519019370c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.83e-05190193bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.83e-051901931f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.83e-05190193e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP1R2 KIT CASZ1

6.83e-051901936847afca73e1b76c2e86187ccb1a164aefd8f17b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R2 FBN1 LAYN

6.83e-05190193be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.83e-051901932306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R2 FBN1 LAYN

6.83e-0519019309a8855901c3c9332dbaab3e40166485b696d0f1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.83e-05190193445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRB ZEB2 FBN1

6.83e-05190193ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.83e-051901932e592323085ba9c019d678ac2a784462ab470ed9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-0519119339092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-3|TCGA-Ovary / Sample_Type by Project: Shred V9

PDGFRB ZEB2 FBN1

6.94e-0519119380d30d8eedb4c70b58440646325bc04c5700803e
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

PDGFRB ZEB2 FBN1

6.94e-0519119378c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

6.94e-05191193ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-051921939093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-05192193bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-051921935105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

JAKMIP2 SPRED1 ZEB2

7.05e-05192193733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-05192193d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-051921939333aba0d04203ccccad78d82bf6359922f810a7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-051921939ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

CASZ1 ARHGEF3 SALL3

7.05e-05192193d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCellEndothelial-A|World / shred on cell class and cell subclass (v4)

PPP1R2 KIT CASZ1

7.05e-051921939919cdc0ce833894525dba429f251ea1b094fbd8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.05e-051921930ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP1R2 KIT CASZ1

7.16e-05193193634fdd157cd1efeebf6ecc810bc45e138331451a
ToppCellE15.5-Mesenchymal|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDGFRB ZEB2 FBN1

7.16e-0519319322a9f5b61f197757f72840b9cb849cdb20430e72
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP1R2 KIT CASZ1

7.16e-05193193ce5c3ab79900aa6f394c894267340167009c6149
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDGFRB ZEB2 FBN1

7.16e-05193193f1199518c3626fd29bfce65070dd21a660671213
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

PDGFRB JAKMIP2 FBN1

7.16e-05193193194e7fa00a50cc4e026987b715323d125d79594e
ComputationalGenes in the cancer module 200.

KIT PDGFRB

6.25e-0427152MODULE_200
ComputationalGenes in the cancer module 80.

KIT PDGFRB

8.80e-0432152MODULE_80
ComputationalDevelopmental processes.

KIT PDGFRB ZEB2 FBN1

9.42e-04333154MODULE_220
ComputationalGenes in the cancer module 51.

KIT PDGFRB

1.11e-0336152MODULE_51
Drugnitrofen

KIT PDGFRB SPRED1 FBN1 SPRED2

1.21e-06237195ctd:C007350
DrugCT52923

KIT PDGFRB

3.95e-064192ctd:C461979
Druglissamine

PHOX2B PDGFRB ZEB2

6.39e-0644193CID005359521
Drugorantinib

KIT PDGFRB

9.88e-066192ctd:C412603
DrugSorafenib

KIT PDGFRB

1.38e-057192DB00398
DrugSunitinib

KIT PDGFRB

1.84e-058192DB01268
DrugImatinib

KIT PDGFRB

1.84e-058192DB00619
DrugIopanoic acid [96-83-3]; Up 200; 7uM; MCF7; HT_HG-U133A

PER1 KIT JAKMIP2 FBN1

1.98e-051991945448_UP
DrugDasatinib

KIT PDGFRB

2.96e-0510192DB01254
DrugSU11652

KIT PDGFRB

3.61e-0511192CID005329103
Drugpazopanib

KIT PDGFRB

4.33e-0512192ctd:C516667
Drugchromium oxide

PER1 NCOA6

5.12e-0513192CID000517276
Drugtandutinib

KIT PDGFRB

6.88e-0515192CID003038522
DrugOPC-18790

PER1 IK

1.00e-0418192CID000060790
DrugEpoxy resin

GPR161 NCOA6

1.37e-0421192CID000169944
Drug1,3,8-triazanaphthalene

KIT PDGFRB

1.80e-0424192CID000582898
Drugeverolimus

PER1 KIT PDGFRB

1.88e-04136193CID006442177
Drugsorafenib

KIT PDGFRB ZEB2

2.46e-04149193ctd:C471405
Drugtrenbolone acetate

PER1 NCOA6

2.64e-0429192CID000066359
DrugDichlorodiphenyldichloroethane

KIT PDGFRB

2.64e-0429192ctd:D003632
Drug2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

PDGFRB FBN1

3.02e-0431192ctd:C577942
DrugEndrin

KIT PDGFRB

3.22e-0432192ctd:D004732
Drugbeta-tyrosine

KIT PDGFRB

3.86e-0435192CID000440311
Drugaminopyrimidine

KIT PDGFRB

3.86e-0435192CID000007978
Drug2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene

KIT PDGFRB

4.09e-0436192ctd:C054919
Drugtrans-retinol acetate

PDGFRB NCOA6

4.09e-0436192CID000005057
DrugMetaraminol bitartrate [33402-03-8]; Up 200; 8.6uM; PC3; HT_HG-U133A

PER1 KIT PDGFRB

4.80e-041871937368_UP
DrugNi-Fe active center

PER1 NCOA6

4.80e-0439192CID005195770
DrugDilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A

PER1 FBN1 SPRED2

4.95e-041891934688_UP
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; PC3; HT_HG-U133A

PER1 GPR161 CASZ1

5.26e-041931934322_UP
DrugmM Q

PER1 IK

5.31e-0441192CID000445446
DrugAlclometasone dipropionate [667634-13-2]; Up 200; 7.6uM; PC3; HT_HG-U133A

PER1 KIT SPRED2

5.34e-041941935752_UP
DrugThioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; PC3; HT_HG-U133A

PER1 KIT PDGFRB

5.34e-041941935791_UP
DrugClofilium tosylate [92953-10-1]; Down 200; 7.8uM; PC3; HT_HG-U133A

KIT GPR161 SPRED2

5.34e-041941934492_DN
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A

KIT JAKMIP2 SPRED2

5.42e-041951932895_UP
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A

GPR161 FBN1 SPRED2

5.42e-041951935582_UP
DrugAllantoin [97-59-6]; Up 200; 25.2uM; PC3; HT_HG-U133A

KIT PDGFRB JAKMIP2

5.50e-041961935052_UP
Drug6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; PC3; HT_HG-U133A

KIT GPR161 FBN1

5.50e-041961934250_UP
DrugMethiazole; Down 200; 15uM; PC3; HT_HG-U133A

PER1 GPR161 FBN1

5.50e-041961933796_DN
DrugPempidine tartrate [546-48-5]; Up 200; 13uM; PC3; HT_HG-U133A

PER1 CASZ1 SPRED2

5.50e-041961934307_UP
DrugIsopropamide iodide [71-81-8]; Up 200; 8.4uM; HL60; HT_HG-U133A

KIT GPR161 FBN1

5.58e-041971932720_UP
DrugSulfamethizole [144-82-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

KIT JAKMIP2 GPR161

5.58e-041971936099_UP
DrugIsoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; HL60; HT_HG-U133A

PHOX2B GPR161 CASZ1

5.58e-041971932463_UP
DrugAzathioprine [446-86-6]; Up 200; 14.4uM; PC3; HT_HG-U133A

KIT GPR161 SPRED2

5.66e-041981934667_UP
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A

PDGFRB GPR161 FBN1

5.66e-041981935615_UP
DrugMetolazone [17560-51-9]; Down 200; 11uM; MCF7; HT_HG-U133A

PER1 JAKMIP2 SPRED2

5.66e-041981935392_DN
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; MCF7; HT_HG-U133A

PHOX2B KIT GPR161

5.66e-041981937232_UP
DrugBiotin [58-85-5]; Up 200; 16.4uM; MCF7; HT_HG-U133A

PHOX2B KIT SPRED2

5.66e-041981933289_UP
DrugTorsemide [56211-40-6]; Down 200; 11.4uM; PC3; HT_HG-U133A

PER1 GPR161 SPRED2

5.75e-041991935057_DN
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; HL60; HT_HG-U133A

PER1 KIT PDGFRB

5.75e-041991932187_UP
DrugPropylthiouracil [51-52-5]; Up 200; 23.4uM; PC3; HT_HG-U133A

PHOX2B GPR161 SPRED2

5.75e-041991934076_UP
Drugzoxazolamine

NCOA6 IK

6.11e-0444192CID000006103
Drugaxitinib

KIT PDGFRB

6.39e-0445192CID006450551
DrugGSK1210151A

PDGFRB FBN1

8.53e-0452192ctd:C568713
DiseaseGastrointestinal Stromal Sarcoma

KIT SALL3

4.17e-0447192C3179349
DiseaseGastrointestinal Stromal Tumors

KIT SALL3

4.72e-0450192C0238198
DiseaseMalignant neoplasm of breast

PER1 KIT NCOA6 ZEB2 BOD1L1

4.80e-041074195C0006142

Protein segments in the cluster

PeptideGeneStartEntry
MDQSDSESDCSMDTS

ARHGEF3

486

Q9NR81
MDAETDECMDYTGCS

CASZ1

1346

Q86V15
GYDEDSMDSETSSMA

JAKMIP2

436

Q96AA8
ESSCSDSTNEYMDMK

KIT

711

P10721
EATPDDMSCDYDNMA

LAYN

321

Q6UX15
SLEEGEPCSMDMSTY

PER1

186

O15534
HSMMGDDEDACSDTE

PPP1R2

76

P41236
LCSSTMEDSEMDFDS

NCOA6

16

Q14686
YSEDKCDMDSTNMDS

BOD1L1

871

Q8NFC6
YDGFMASEDMKTCVD

FBN1

1266

P35555
SGTDMMLLEDYTSDD

GPR161

401

Q8N6U8
ETLSSYDDDMDENSM

SALL3

791

Q9BXA9
SDGGYMDMSKDESVD

PDGFRB

736

P09619
CAESMLYHCMSDSEG

SPRED1

371

Q7Z699
ADSMLYHCMSDPEGD

SPRED2

346

Q7Z698
AECYPATMDDMAVDS

IK

446

Q13123
MPFMDESSGSDDDCS

PLEKHH1

486

Q9ULM0
DYMSGLDDMTDSDSC

ZEB2

971

O60315
SSAYESCMAGMDTSS

PHOX2B

11

Q99453