Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

4.49e-124317516GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

4.28e-108847519GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 ROBO2 OR5H2 OR7A17 OR14A16 OR4L1 GABRA5

1.48e-0813537521GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5M10 OR8U1 OR14A2 OR5M1 OR6N2 OR5H2 OR14A16

4.94e-07127757GO:0005549
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNG2 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1

6.04e-073437510GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNG2 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1 GABRA5

1.09e-064597511GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1

1.24e-064657511GO:0046873
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN3A SCN8A SLC4A11 TPCN1

1.48e-0652755GO:0005272
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN3A SCN8A TPCN1

2.58e-0626754GO:0005248
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A12 SLC24A2 SCN1A SCN3A SCN8A SLC4A11 TPCN1

3.63e-06171757GO:0015081
GeneOntologyMolecularFunctionchannel activity

KCNG2 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1 GABRA5

4.00e-065257511GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNG2 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1 GABRA5

4.08e-065267511GO:0022803
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN3A SCN8A

1.80e-0514753GO:0031402
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1

2.12e-056277511GO:0022890
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1 GABRA5

2.38e-057587512GO:0015318
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC35D2 SLC24A2 KCNH2 SCN1A SCN3A SCN8A SVOPL KCNK4 SLC38A8 SLC4A11 TPCN1 GABRA5

2.74e-0511807515GO:0022857
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1

3.58e-056647511GO:0008324
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A KCNK4 SLC4A11 TPCN1 GABRA5

3.71e-057937512GO:0015075
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNG2 CACNA2D1 KCNH2 SCN1A KCNK4 TPCN1

6.71e-05184756GO:0022832
GeneOntologyMolecularFunctiontransporter activity

KCNG2 SLC6A12 CACNA2D1 SLC35D2 SLC24A2 KCNH2 SCN1A SCN3A SCN8A SVOPL KCNK4 SLC38A8 SLC4A11 TPCN1 GABRA5

7.53e-0512897515GO:0005215
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN3A SCN8A

1.24e-0426753GO:0031420
GeneOntologyMolecularFunctiongated channel activity

KCNG2 CACNA2D1 KCNH2 SCN1A KCNK4 TPCN1 GABRA5

2.58e-04334757GO:0022836
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNG2 CACNA2D1 KCNH2 SCN1A KCNK4

6.13e-04182755GO:0005244
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNG2 CACNA2D1 KCNH2 KCNK4

2.58e-03152754GO:0022843
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNG2 SLC24A2 KCNH2 KCNK4

3.62e-03167754GO:0015079
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNG2 KCNH2

4.94e-0328752GO:0005251
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 SCN1A OR13F1 OR5H2 OR7A17 OR14A16 KCNK4 OR4L1

2.13e-125827518GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

2.87e-124327516GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus

CD1D OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 SCN1A OR13F1 OR5H2 OR7A17 OR14A16 KCNK4 OR4L1

7.86e-127227519GO:0051606
GeneOntologyBiologicalProcesssensory perception of smell

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

8.70e-124657516GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

1.63e-114857516GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

5.15e-115247516GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

9.71e-115477516GO:0007606
GeneOntologyBiologicalProcesssensory perception

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 SCN1A OR13F1 SCN8A MRGPRX2 OR5H2 OR7A17 OR14A16 KCNK4 SLC38A8 OR4L1

1.27e-1010727521GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 ECEL1 OR7A17 CX3CL1 OR14A16 OR4L1 HTT

2.49e-0913957522GO:0007186
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

1.92e-0736755GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

3.06e-0662755GO:0086002
GeneOntologyBiologicalProcessregulation of membrane potential

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 CNIH3 SLC4A11 GABRA5

5.35e-065597511GO:0042391
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A12 SLC24A2 SCN1A SCN3A SCN8A SLC4A11 TPCN1

1.06e-05208757GO:0035725
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1 GABRA5

1.54e-0510177514GO:0098660
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

1.63e-0587755GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

2.25e-0593755GO:0086003
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1

2.53e-059227513GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1

3.16e-059427513GO:0098655
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1 GABRA5

4.26e-0511157514GO:0034220
GeneOntologyBiologicalProcessmetal ion transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1

5.84e-0510007513GO:0030001
GeneOntologyBiologicalProcesssodium ion transport

SLC6A12 SLC24A2 SCN1A SCN3A SCN8A SLC4A11 TPCN1

6.35e-05275757GO:0006814
GeneOntologyBiologicalProcessmembrane depolarization

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

7.95e-05121755GO:0051899
GeneOntologyBiologicalProcessaction potential

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

9.15e-05201756GO:0001508
GeneOntologyBiologicalProcessactin-mediated cell contraction

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

1.00e-04127755GO:0070252
GeneOntologyBiologicalProcessactin filament-based movement

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

2.39e-04153755GO:0030048
GeneOntologyBiologicalProcessmonoatomic cation transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1

2.50e-0411577513GO:0006812
GeneOntologyBiologicalProcesscardiac muscle contraction

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

3.58e-04167755GO:0060048
GeneOntologyBiologicalProcessmonoatomic ion transport

KCNG2 SLC6A12 CACNA2D1 SLC24A2 KCNH2 SCN1A SCN3A SCN8A CX3CL1 KCNK4 SLC4A11 HTT TPCN1 GABRA5

3.83e-0413747514GO:0006811
GeneOntologyBiologicalProcessendoplasmic reticulum organization

ATL3 ATL2 BAG6 HTT

6.27e-04107754GO:0007029
GeneOntologyBiologicalProcessnerve development

SCN1A SCN8A SLC38A8 GABRA5

6.72e-04109754GO:0021675
GeneOntologyBiologicalProcessheart contraction

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

7.55e-04298756GO:0060047
GeneOntologyBiologicalProcessheart process

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A

9.11e-04309756GO:0003015
GeneOntologyBiologicalProcesspositive T cell selection

CD1D CTSV ZAP70

9.49e-0453753GO:0043368
GeneOntologyBiologicalProcessurea cycle

AGMAT HTT

9.92e-0413752GO:0000050
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A KCNK4 CNIH3 TPCN1 GABRA5

1.10e-063787610GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A KCNK4 CNIH3 TPCN1 GABRA5

1.92e-055237610GO:1902495
GeneOntologyCellularComponentcation channel complex

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A KCNK4

2.35e-05235767GO:0034703
GeneOntologyCellularComponenttransporter complex

KCNG2 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A KCNK4 CNIH3 TPCN1 GABRA5

2.94e-055507610GO:1990351
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN3A SCN8A

3.03e-0517763GO:0001518
GeneOntologyCellularComponentplasma membrane protein complex

KCNG2 TRBV30 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A CDH7 ITGB6 ZAP70 CNIH3

1.21e-047857611GO:0098797
GeneOntologyCellularComponentendoplasmic reticulum tubular network membrane

ATL3 ATL2

1.30e-045762GO:0098826
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN3A SCN8A

1.58e-0429763GO:0034706
GeneOntologyCellularComponentmembrane protein complex

KCNG2 TRBV30 CACNA2D1 KCNH2 SCN1A SCN3A SCN8A CDH7 ITGB6 ZAP70 KCNK4 CNIH3 TPCN1 GABRA5

9.09e-0414987614GO:0098796
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN8A

2.38e-0320762GO:0033268
HumanPhenoClonic seizure

CACNA2D1 SCN1A SCN3A SCN8A KCNK4

1.15e-0581205HP:0020221
HumanPhenoEEG with abnormally slow frequencies

CACNA2D1 SCN1A SCN3A SCN8A GABRA5

1.73e-0588205HP:0011203
HumanPhenoFocal clonic seizure

CACNA2D1 SCN1A SCN8A KCNK4

1.76e-0542204HP:0002266
HumanPhenoEEG with multifocal slow activity

CACNA2D1 SCN3A SCN8A GABRA5

4.15e-0552204HP:0010844
HumanPhenoFocal impaired awareness seizure

CACNA2D1 SCN1A SCN3A SCN8A HTT

9.84e-05126205HP:0002384
HumanPhenoFocal hemiclonic seizure

CACNA2D1 SCN1A SCN8A

1.13e-0425203HP:0006813
HumanPhenoRigidity

CACNA2D1 SCN1A SCN3A SCN8A HTT GABRA5

1.21e-04214206HP:0002063
HumanPhenoSimple febrile seizure

SCN1A SCN3A SCN8A

1.43e-0427203HP:0011171
HumanPhenoImpulsivity

CACNA2D1 SCN1A SCN3A SCN8A GABRA5

2.18e-04149205HP:0100710
HumanPhenoFocal-onset seizure

CACNA2D1 SCN1A SCN3A SCN8A KCNK4 HTT GABRA5

2.25e-04346207HP:0007359
HumanPhenoAbnormal involuntary eye movements

CACNA2D1 FAT2 FANCI TPP1 SCN1A SCN3A SCN8A KCNK4 SLC38A8 SLC4A11 HTT GABRA5

2.64e-0411232012HP:0012547
HumanPhenoUnsteady gait

CACNA2D1 TPP1 SCN1A SCN3A SCN8A HTT GABRA5

2.73e-04357207HP:0002317
HumanPhenoMyoclonus

CACNA2D1 TPP1 SCN1A SCN3A SCN8A HTT GABRA5

3.47e-04371207HP:0001336
DomainOlfact_rcpt

OR5M10 OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

2.58e-113937315IPR000725
DomainGPCR_Rhodpsn_7TM

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

6.71e-116707318IPR017452
Domain7tm_1

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

7.95e-116777318PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

9.62e-116857318PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

1.11e-106917318PS50262
DomainGPCR_Rhodpsn

OR5M10 PRLHR OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 GPR135 MRGPRX2 OR5H2 OR7A17 OR14A16 OR4L1

1.13e-106927318IPR000276
DomainNa_trans_cytopl

SCN1A SCN3A SCN8A

1.14e-066733PF11933
DomainNa_trans_cytopl

SCN1A SCN3A SCN8A

1.14e-066733IPR024583
DomainChannel_four-helix_dom

KCNG2 SCN1A SCN3A SCN8A TPCN1

2.84e-0657735IPR027359
Domain-

KCNG2 SCN1A SCN3A SCN8A TPCN1

2.84e-06577351.20.120.350
DomainIon_trans_dom

KCNG2 KCNH2 SCN1A SCN3A SCN8A TPCN1

5.53e-06114736IPR005821
DomainIon_trans

KCNG2 KCNH2 SCN1A SCN3A SCN8A TPCN1

5.53e-06114736PF00520
DomainNa_channel_asu

SCN1A SCN3A SCN8A

6.74e-0610733IPR001696
DomainNa_trans_assoc

SCN1A SCN3A SCN8A

6.74e-0610733IPR010526
DomainNa_trans_assoc

SCN1A SCN3A SCN8A

6.74e-0610733PF06512
DomainTetraspanin_CS

CD37 TSPAN3 TSPAN1

7.24e-0521733IPR018503
DomainTM4_1

CD37 TSPAN3 TSPAN1

1.40e-0426733PS00421
DomainTetraspanin

CD37 TSPAN3 TSPAN1

2.62e-0432733IPR000301
DomainTetraspanin_EC2

CD37 TSPAN3 TSPAN1

2.62e-0432733IPR008952
DomainTetraspannin

CD37 TSPAN3 TSPAN1

2.87e-0433733PF00335
DomainTetraspanin/Peripherin

CD37 TSPAN3 TSPAN1

2.87e-0433733IPR018499
DomainGBP_C

ATL3 ATL2

6.64e-0410732PF02841
DomainG_GB1_RHD3_dom

ATL3 ATL2

8.10e-0411732IPR030386
DomainGuanylate-bd_C

ATL3 ATL2

8.10e-0411732IPR003191
DomainGBP

ATL3 ATL2

8.10e-0411732PF02263
DomainGuanylate-bd_N

ATL3 ATL2

8.10e-0411732IPR015894
DomainG_GB1_RHD3

ATL3 ATL2

8.10e-0411732PS51715
DomainIQ

SCN1A SCN3A SCN8A

2.71e-0371733PF00612
DomainIQ

SCN1A SCN3A SCN8A

3.93e-0381733SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN3A SCN8A

5.28e-0390733IPR000048
DomainIQ

SCN1A SCN3A SCN8A

5.78e-0393733PS50096
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

8.84e-124175916M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5M10 OR4C3 OR4N2 OR8U1 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

4.13e-113895915M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR6C70 OR13F1 SCN3A OR5H2 OR7A17 OR14A16 OR4L1

5.07e-106365917M41834
PathwayREACTOME_CARDIAC_CONDUCTION

KCNH2 SCN1A SCN3A SCN8A KCNK4

2.07e-04130595M27454
PathwayWP_DRAVET_SYNDROME

SCN1A SCN3A SCN8A

2.12e-0428593M45519
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN3A SCN8A

2.88e-0431593M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN3A SCN8A

3.17e-0432593M27455
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR6C70 OR13F1 OR5H2 OR7A17 OR4L1

1.04e-12340801311875048
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR6C70 OR13F1 OR5H2 OR7A17 OR4L1

1.16e-12343801332295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6S1 OR6N2 OR6C70 OR13F1 OR5H2 OR7A17 OR4L1

1.29e-12346801314611657
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5M10 OR4C3 OR4N2 OR8U1 OR14A2 OR5M1 OR6N2 OR6C70 OR13F1 OR5H2 OR7A17 OR4L1

2.09e-11340801211802173
Pubmed

The human olfactory receptor gene family.

OR5M10 OR4C3 OR4N2 OR5M1 OR6S1 OR6N2 OR10H2 OR4N4 OR13F1 OR5H2 OR7A17 OR14A16 OR4L1

3.30e-10541801314983052
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN3A SCN8A

4.68e-08480317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN3A SCN8A

4.68e-08480335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN3A SCN8A

4.68e-08480329578003
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN3A SCN8A

2.33e-07680323652591
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA2D1 KCNH2 SCN1A SCN3A SCN8A KCNK4

8.62e-0713980616985003
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN3A SCN8A

9.75e-07980316382098
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN3A SCN8A

9.75e-07980315746173
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN3A SCN8A

2.54e-061280330175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN3A SCN8A

3.30e-061380315123669
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

5.23e-06280237901435
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

5.23e-06280226410685
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

5.23e-06280224990319
Pubmed

Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.

ATL3 ATL2

5.23e-06280218270207
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

5.23e-06280233411788
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

5.23e-06280231943325
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

5.23e-06280227690330
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

5.23e-06280223965409
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

5.23e-06280237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

5.23e-06280217881658
Pubmed

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.

CD1D CX3CL1

1.57e-05380216675847
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN3A

1.57e-05380212610651
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

1.57e-05380233895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN3A

1.57e-05380223859570
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN3A

1.57e-05380218784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN3A

1.57e-05380217544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN8A

1.57e-05380232845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN8A

1.57e-05380228518218
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.57e-05380227816501
Pubmed

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes.

ATL3 ATL2

1.57e-05380225773277
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

1.57e-05380224704313
Pubmed

Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy.

ATL3 ATL2

1.57e-05380233988678
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

1.57e-05380228117367
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN8A

1.57e-05380217928448
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN3A

1.57e-05380214973256
Pubmed

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.

ATL3 ATL2

1.57e-05380227669642
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

1.57e-05380226182346
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

1.57e-05380231054517
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ENTPD7 NEMP1 CACNA2D1 DPY19L3 CSGALNACT2 FANCI LAMB1 ECEL1 SPINK6 TSPAN3 HTT TPCN1

1.88e-051201801235696571
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

CD37 TSPAN3 TSPAN1

2.29e-052480311739647
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR6S1 OR6C70 OR7A17 OR4L1

2.64e-057480415081110
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN8A

3.13e-05480221156207
Pubmed

Models for discovery of targeted therapy in genetic epileptic encephalopathies.

SCN1A SCN8A

3.13e-05480228742937
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN3A

3.13e-05480235801810
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN3A

3.13e-0548028974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN3A

5.20e-0558021679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN3A

5.20e-0558028812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN8A

5.20e-05580222875929
Pubmed

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network.

ATL3 ATL2

5.20e-05580227619977
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN3A SCN8A

5.20e-05580217724025
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN3A

5.20e-05580224337656
Pubmed

A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.

CACNA2D1 KCNH2 KCNK4

6.08e-053380310843805
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN3A SCN8A

7.79e-05680223711479
Pubmed

Sequences and expression of six new members of the tetraspanin/TM4SF family.

TSPAN3 TSPAN1

7.79e-0568029714763
Pubmed

A class of dynamin-like GTPases involved in the generation of the tubular ER network.

ATL3 ATL2

1.09e-04780219665976
Pubmed

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.

ATL3 ATL2

1.09e-04780223969831
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN8A

1.09e-04780225818041
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN8A

1.09e-04780215272007
Pubmed

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.

MRGPRX2 ITGB6

1.09e-04780233765440
Pubmed

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.

FANCI HTT

1.45e-04880234469738
Pubmed

The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network.

ATL3 ATL2

1.86e-04980232916628
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN8A

1.86e-04980217884088
Pubmed

Identification of ligands for olfactory receptors by functional expression of a receptor library.

OR8U1 OR7A17

3.40e-04128029875846
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN3A

3.40e-04128028169823
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN3A

5.38e-04158029726281
Pubmed

High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.

TPP1 CTSV

5.38e-041580216170054
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN3A ITGB6

5.98e-04718038751373
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

CD1D SMG7 GIMAP2 TMEM121B ASGR2 IL22 CX3CL1 ITGB6

6.19e-0482480820237496
Pubmed

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

IL22 LAMB1

6.95e-041780219122664
Pubmed

Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease.

LAMB1 HTT

7.81e-041880219955426
Pubmed

Appearance of new tetraspanin genes during vertebrate evolution.

TSPAN3 TSPAN1

9.66e-042080218291621
Pubmed

An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.

SLC6A12 PRLHR LAMB1

9.76e-048480315123239
Pubmed

Brugada Syndrome

CACNA2D1 KCNH2

1.40e-032480220301690
Pubmed

Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.

SCN8A LAMB1

1.64e-03268029226367
Pubmed

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.

KCNH2 ROBO2

1.64e-032680231138815
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR14A2 OR5M1 OR10H2 OR7A17

1.66e-0321980412213199
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR5H2 OR7A17

1.77e-032780232061665
Pubmed

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

BAG6 HTT

1.90e-032880225752541
Pubmed

ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.

ROBO2 CDH7

1.90e-032880236074819
Pubmed

Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.

CACNA2D1 LAMB1

2.18e-033080218055048
InteractionNDFIP1 interactions

ENTPD7 OR10H2 C19orf18 CX3CL1 KCNK4 TSPAN3

1.46e-06105686int:NDFIP1
InteractionDAGLB interactions

ENTPD7 TMEM171 OR10H2 TSPAN3 SFT2D1

1.64e-0659685int:DAGLB
InteractionCLDN11 interactions

FNDC9 TSPAN3 HTT

2.89e-0518683int:CLDN11
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN3A SCN8A

2.88e-0696031203
GeneFamilyCD molecules|Tetraspanins

CD37 TSPAN3 TSPAN1

1.77e-0433603768
GeneFamilyOlfactory receptors, family 14

OR14A2 OR14A16

2.25e-047602163
GeneFamilyOlfactory receptors, family 6

OR6S1 OR6N2 OR6C70

6.46e-0451603153
GeneFamilyOlfactory receptors, family 4

OR4C3 OR4N2 OR4N4 OR4L1

8.86e-04129604151
GeneFamilyOlfactory receptors, family 5

OR5M10 OR5M1 OR5H2

6.13e-03112603152
GeneFamilyPotassium voltage-gated channels

KCNG2 KCNH2

7.79e-0340602274
GeneFamilySolute carriers

SLC6A12 SLC35D2 SLC24A2 SLC38A8 SLC4A11

9.91e-03395605752
CoexpressionPHESSE_TARGETS_OF_APC_AND_MBD2_UP

CACNA2D1 TMEM121B FNDC9

1.85e-0518763M2201
CoexpressionPHESSE_TARGETS_OF_APC_AND_MBD2_UP

CACNA2D1 TMEM121B FNDC9

2.58e-0520763MM890
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3|Hippocampus / BrainAtlas - Mouse McCarroll V32

THSD4 KCNG2 ERP27 ZAP70 KCNK4 SLC38A8

9.04e-081277769bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 KCNH2 SCN1A IL22 TMEM151B SCN8A

8.03e-071847767d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 CACNA2D1 KCNH2 LAMB1 ROBO2 CNIH3

1.31e-06200776a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CACNA2D1 TMEM121B FNDC9 SLC4A11 GABRA5

8.58e-06160775f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellfacs-GAT-Fat-24m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM171 CD1D FAT2 CD37 ZAP70

9.39e-06163775e58863a462cc504bced627f004a47890ee2307ce
ToppCellMonocytes-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CD1D RNASE3 CSGALNACT2 ASGR2 CD37

1.09e-051687759ea3c682ce4e98f1a3303f99b4c63c2cf8863abc
ToppCellcontrol-Myeloid-Mast_cell|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CACNA2D1 GIMAP2 KCNH2 CD37 TM6SF1

1.22e-05172775c1c99e6732234a6649a79610e99390db0c8f19b0
ToppCellNS-control-d_0-4-Myeloid-Mast_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CACNA2D1 GIMAP2 KCNH2 CD37 TM6SF1

1.29e-051747752d1f5c17b1551f32f49618ec1bf68eafbfd02ace
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KCNG2 CACNA2D1 TMEM121B CNIH3 GABRA5

1.32e-05175775ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KCNG2 CACNA2D1 TMEM121B CNIH3 GABRA5

1.32e-0517577521f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A IL22 TMEM151B CDH7 TSPAN1

1.52e-05180775f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellnormal_Lymph_Node-Myeloid_cells-Pleural_Mac|normal_Lymph_Node / Location, Cell class and cell subclass

SLC6A12 CD1D TMEM121B ASGR2 OR6C70

1.56e-05181775921e917f83105896ad8918dc134b871708024021
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH2 SCN1A TMEM151B SCN8A CDH7

1.87e-051887751efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A FNDC9 ROBO2 CNIH3 GABRA5

2.12e-05193775461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A FNDC9 ROBO2 CNIH3 GABRA5

2.12e-051937750dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A FNDC9 ROBO2 CNIH3 GABRA5

2.23e-05195775ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMEM171 FAT2 ERP27 CX3CL1 SVOPL

2.34e-05197775751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Basal_1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

TMEM171 FAT2 ERP27 CX3CL1 SVOPL

2.34e-051977752701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM171 FAT2 ERP27 CX3CL1 SVOPL

2.34e-0519777558d809ccb8cc4b1e76acf0b8f996cd0e2637290c
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Monocytic-Monocyte_CD16|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CD1D CSGALNACT2 GIMAP2 ASGR2 CD37

2.52e-0520077594d7aa057a31287696a634d15ce91ce64af6455b
ToppCellSubstantia_nigra-Neuronal-Excitatory|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA2D1 KCNK4 CNIH3 GABRA5

5.25e-051187749f1d744f46d79ff2ab7f168f54fdbd9f4640dddd
DrugAPETx1, Anthopleura elegantissima

KCNH2 SCN3A SCN8A

7.38e-076773ctd:C475726
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN3A SCN8A

1.79e-0610743DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN3A SCN8A

1.79e-0610743DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN3A SCN8A

3.28e-0612743DOID:0060170 (implicated_via_orthology)
Diseasehereditary spastic paraplegia 3A (implicated_via_orthology)

ATL3 ATL2

1.86e-053742DOID:0110791 (implicated_via_orthology)
DiseaseShort QT Syndrome 1

CACNA2D1 KCNH2

3.71e-054742C1865020
DiseaseIntellectual Disability

OR5M1 TPP1 SCN1A SCN3A SCN8A KCNK4 HTT

1.31e-04447747C3714756
DiseaseShortened QT interval

CACNA2D1 KCNH2

3.36e-0411742C0151879
Diseaseepilepsy (implicated_via_orthology)

KCNH2 SCN1A SCN3A SCN8A

7.64e-04163744DOID:1826 (implicated_via_orthology)
Diseaseerythritol measurement

CACNA2D1 ITGB6

8.24e-0417742EFO_0021171
Diseasealpha-tocopherol measurement

CACNA2D1 SCN3A

1.14e-0320742EFO_0007898
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN3A

1.39e-0322742DOID:2030 (implicated_via_orthology)
DiseaseEtat Marbre

SCN1A HTT

1.52e-0323742C0266487
DiseaseBrugada Syndrome (disorder)

CACNA2D1 KCNH2

1.65e-0324742C1142166
DiseaseCardiac Arrhythmia

CACNA2D1 KCNH2

1.79e-0325742C0003811
DiseaseMovement Disorders

SCN1A HTT

2.41e-0329742C0026650

Protein segments in the cluster

PeptideGeneStartEntry
ALAFAAIQLLGMLCA

TSPAN3

216

O60637
MLCSLLALLLGTFFG

TRBV30

1

A0A0K0K1B3
FGALLSLLCQNFSMV

BAG6

751

P46379
MNLSLVLAAFCLGIA

CTSV

1

O60911
MVCFSLLALSFNILL

ASGR2

56

P07307
SGFLILFLFLMECQL

C19orf18

6

Q8NEA5
CILQFFNSMILGSLL

DPY19L3

301

Q6ZPD9
LHLFMVLCLTLFLNN

DPY19L3

346

Q6ZPD9
FLAIYLITLAGNLCM

OR5M10

31

Q6IEU7
FNSGLMTLLCFLGLL

OR4N4C

201

A0A096LPK9
FLFLLLNCVLSMIGN

OR6C70

26

A6NIJ9
DALFCKSLMNLLFSL

FANCI

1021

Q9NVI1
MALLGCFLLILLSYA

OR10H2

206

O60403
FLGLFFISCLLLLML

ENTPD7

31

Q9NQZ7
SAMLFLLIGCLLFVL

KCNK4

171

Q9NYG8
LMAILLACFTAVLAF

FNDC9

116

Q8TBE3
GAAVLFLLMCTFALI

KCNH2

546

Q12809
MTIALLGFAIFLLHC

FAT2

1

Q9NYQ8
MGIELLCLFFLFLGR

ITGB6

1

P18564
EFGLLLLFLCVAMAL

KCNG2

321

Q9UJ96
FLLGNLSFLDMCLST

OR4L1

61

Q8NH43
FNSGLMTLLCFLGLL

OR4N2

201

Q8NGD1
FNSGLMTLLCFLGLL

OR4N4

201

Q8N0Y3
MNNSLCIRLLAFSFL

OR5H2

141

Q8NGV7
VFLLGLMLFFCGDLL

NEMP1

166

O14524
LMLFFCGDLLSRSQI

NEMP1

171

O14524
FTSQICLLLLLGLMG

RNASE3

6

P12724
FGMLCGLSLFNLNVA

HERC6

761

Q8IVU3
MGLLQLLAFSFLALC

LAMB1

1

P07942
FSGFIMIKNLLLFCI

GABRA5

6

P31644
LVFAAGLCAILAAML

ECEL1

66

O95672
LLLAYLFTICGNMLI

OR6N2

31

Q8NGY6
MYFFLGNLSCLEILL

OR6S1

61

Q8NH40
LLGLALLCSLVLFMY

CSGALNACT2

16

Q8N6G5
FQKLLGIAMELFLLC

HTT

121

P42858
LLIFLLSSLGNCAVM

GPR135

111

Q8IZ08
LLFSMCNLFCSLLFI

GIMAP2

301

Q9UG22
MAAGCLLALTLTLFQ

CACNA2D1

1

P54289
SMGLIALAVLACLLF

CD1D

301

P15813
AVLCNLVMGLALIFL

ATL2

501

Q8NHH9
QLFNCMVGLLLIALL

ATL3

471

Q6DD88
SRFMFLLFLLTCELA

ERP27

6

Q96DN0
MFLLLSLALFCFLTG

SPINK6

6

Q6UWN8
FLQLIALFLCFSGMS

CDH7

11

Q9ULB5
MNLCLSALLFFLVIL

DEFB136

1

Q30KP8
ELGFMTLSIFLCRNL

CD37

256

P11049
CLLMYLITLLGNIFL

OR13F1

31

Q8NGS4
SILGCAFQLLLMTSF

OR14A2

91

Q96R54
SILFLLIYLCALMGN

OR14A16

26

Q8NHC5
SGLICLLNFLMLAAS

OR4C3

201

Q8NH37
LGCFLTFMISESLLL

OR8U1

101

Q8NH10
VLQLLLLCAFGMSSL

SLC4A11

821

Q8NBS3
ILQFLLSCFLGFLLM

SLC35D2

241

Q76EJ3
NFLIGNLALSDVLMC

PRLHR

96

P49683
LSIFMLKNLFFLGCR

TMEM121B

496

Q9BXQ6
LLLSLLMYGCLGAVA

TMEM151B

66

Q8IW70
NGLFCAIVLLFIMLL

SLC24A2

601

Q9UI40
FLAIYLITLAGNLCM

OR5M1

31

Q8NGP8
LLALFMSFLGILCKC

SMG7

331

Q92540
SCLFFIMLIFLGLDS

SLC6A12

381

P48065
TALLAANLLFEMLCA

AGMAT

331

Q9BSE5
MCFFVLFGGLDSLLL

OR7A17

101

O14581
FCLSVFALIGLQLFM

SCN3A

256

Q9NY46
FLMGTLATSCLLLLA

IL22

11

Q9GZX6
ACFLLNLLMISVAFL

SLC38A8

106

A6NNN8
LIFLFMVLCGSSLAL

MRGPRX2

191

Q96LB1
ITMGCTALFFLLLNI

SVOPL

376

Q8N434
FCLSVFALIGLQLFM

SCN1A

256

P35498
MLSLVLCAALIFFAI

CNIH3

11

Q8TBE1
KGLAVLFCILQFLSM

SFT2D1

121

Q8WV19
LAGMADGLFLLRQCL

ZAP70

26

P43403
CLSVFALIGLQLFMG

SCN8A

261

Q9UQD0
MSLLMFTQLLLCGFL

ROBO2

1

Q9HCK4
QCLIFGFLFLTSGML

TMEM171

111

Q8WVE6
VFAFLGLLALALNME

TPCN1

516

Q9ULQ1
DLNLSLFLGLCLMLL

TTTY13

21

Q9BZ97
MGSLSVLCFLLLLGF

THSD4

6

Q6ZMP0
LAFLGLLFCLGVAMF

CX3CL1

346

P78423
FDLMLVVCLLLATGF

TM6SF1

216

Q9BZW5
MILFNLLIFLCGAAL

TSPAN1

11

O60635
MGLQACLLGLFALIL

TPP1

1

O14773
MLNVSGLFVLLCGLL

BPIFA4P

1

Q86YQ2