Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	1.43e-04	8	48	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	1.84e-04	9	48	2	GO:0044217
Domain	C345C	NTN4 C4A C4B	1.12e-05	17	49	3	SM00643
Domain	NTR	NTN4 C4A C4B	1.60e-05	19	49	3	PF01759
Domain	Netrin_module_non-TIMP	NTN4 C4A C4B	1.60e-05	19	49	3	IPR018933
Domain	NTR	NTN4 C4A C4B	2.90e-05	23	49	3	PS50189
Domain	Netrin_domain	NTN4 C4A C4B	2.90e-05	23	49	3	IPR001134
Domain	TIMP-like_OB-fold	NTN4 C4A C4B	4.23e-05	26	49	3	IPR008993
Domain	Anaphylatoxin_comp_syst	C4A C4B	6.71e-05	5	49	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	6.71e-05	5	49	2	IPR001840
Domain	ANATO	C4A C4B	1.40e-04	7	49	2	SM00104
Domain	ANATO	C4A C4B	1.40e-04	7	49	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	1.40e-04	7	49	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.40e-04	7	49	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	1.40e-04	7	49	2	IPR000020
Domain	Laminin_G_2	CNTNAP2 CNTNAP4 COL5A3	1.57e-04	40	49	3	PF02210
Domain	Thiol-ester_cl	C4A C4B	1.87e-04	8	49	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.87e-04	8	49	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	1.87e-04	8	49	2	IPR019742
Domain	LamG	CNTNAP2 CNTNAP4 COL5A3	2.08e-04	44	49	3	SM00282
Domain	A2M_N	C4A C4B	2.99e-04	10	49	2	PF01835
Domain	A2M_N	C4A C4B	2.99e-04	10	49	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	2.99e-04	10	49	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	2.99e-04	10	49	2	PS00477
Domain	NHL	TRIM32 LRP1B	2.99e-04	10	49	2	PF01436
Domain	A2M	C4A C4B	2.99e-04	10	49	2	PF00207
Domain	A2M_N_2	C4A C4B	2.99e-04	10	49	2	IPR011625
Domain	A2M_comp	C4A C4B	2.99e-04	10	49	2	IPR011626
Domain	A2M_N_2	C4A C4B	2.99e-04	10	49	2	PF07703
Domain	A2M_recep	C4A C4B	2.99e-04	10	49	2	PF07677
Domain	A2M_comp	C4A C4B	2.99e-04	10	49	2	PF07678
Domain	NHL_repeat	TRIM32 LRP1B	2.99e-04	10	49	2	IPR001258
Domain	Macroglobln_a2	C4A C4B	2.99e-04	10	49	2	IPR001599
Domain	Laminin_G	CNTNAP2 CNTNAP4 COL5A3	4.73e-04	58	49	3	IPR001791
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.00e-03	18	49	2	IPR008930
Domain	FA58C	CNTNAP2 CNTNAP4	1.37e-03	21	49	2	SM00231
Domain	FA58C_3	CNTNAP2 CNTNAP4	1.37e-03	21	49	2	PS50022
Domain	FA58C_1	CNTNAP2 CNTNAP4	1.37e-03	21	49	2	PS01285
Domain	FA58C_2	CNTNAP2 CNTNAP4	1.37e-03	21	49	2	PS01286
Domain	-	CMIP LRRC45 FBXO41 PIDD1 LGR6	1.49e-03	321	49	5	3.80.10.10
Domain	L_dom-like	CMIP LRRC45 FBXO41 PIDD1 LGR6	1.64e-03	328	49	5	IPR032675
Domain	F5_F8_type_C	CNTNAP2 CNTNAP4	1.79e-03	24	49	2	PF00754
Domain	FA58C	CNTNAP2 CNTNAP4	1.79e-03	24	49	2	IPR000421
Domain	Galactose-bd-like	NTN4 CNTNAP2 CNTNAP4	1.92e-03	94	49	3	IPR008979
Domain	-	CNTNAP2 CNTNAP4 COL5A3	1.98e-03	95	49	3	2.60.120.200
Domain	FIBRINOGEN_C_1	CNTNAP2 CNTNAP4	3.18e-03	32	49	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	CNTNAP2 CNTNAP4	3.18e-03	32	49	2	IPR002181
Domain	FIBRINOGEN_C_2	CNTNAP2 CNTNAP4	3.18e-03	32	49	2	PS51406
Domain	EGF	CNTNAP2 CNTNAP4 LRP1B	4.41e-03	126	49	3	PF00008
Domain	EGF_1	NTN4 CNTNAP2 CNTNAP4 LRP1B	4.44e-03	255	49	4	PS00022
Domain	LAM_G_DOMAIN	CNTNAP2 CNTNAP4	4.46e-03	38	49	2	PS50025
Domain	-	TRIM32 LRP1B	4.70e-03	39	49	2	2.120.10.30
Domain	EGF-like_CS	NTN4 CNTNAP2 CNTNAP4 LRP1B	4.82e-03	261	49	4	IPR013032
Domain	6-blade_b-propeller_TolB-like	TRIM32 LRP1B	6.48e-03	46	49	2	IPR011042
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.11e-04	7	33	2	MM14685
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	MAP3K9 C4A C4B	1.26e-04	42	33	3	MM15945
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.47e-04	8	33	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	1.47e-04	8	33	2	M47872
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	2.88e-04	11	33	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	2.88e-04	11	33	2	M47874
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	3.46e-04	12	33	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	4.08e-04	13	33	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	5.47e-04	15	33	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM1369
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	9.83e-04	20	33	2	M917
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	TRIM32 ANAPC1 MRC2 FBXO41 UBA6	1.12e-03	343	33	5	MM15712
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	1.19e-03	22	33	2	M39502
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.03e-06	2	50	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.03e-06	2	50	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.03e-06	2	50	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.03e-06	2	50	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.03e-06	2	50	2	17728371
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.03e-06	2	50	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.03e-06	2	50	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.03e-06	2	50	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.03e-06	2	50	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.03e-06	2	50	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.03e-06	2	50	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.03e-06	2	50	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.03e-06	2	50	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.03e-06	2	50	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.03e-06	2	50	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.03e-06	2	50	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	2.03e-06	2	50	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.03e-06	2	50	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.03e-06	2	50	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.03e-06	2	50	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.03e-06	2	50	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	2.03e-06	2	50	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	2.03e-06	2	50	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	2.03e-06	2	50	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	2.03e-06	2	50	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.03e-06	2	50	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.03e-06	2	50	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	2.03e-06	2	50	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.03e-06	2	50	2	7365238
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.03e-06	2	50	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.03e-06	2	50	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	2.03e-06	2	50	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.03e-06	2	50	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	2.03e-06	2	50	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.03e-06	2	50	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.03e-06	2	50	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	2.03e-06	2	50	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	2.03e-06	2	50	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	2.03e-06	2	50	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	2.03e-06	2	50	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	2.03e-06	2	50	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.03e-06	2	50	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.03e-06	2	50	2	17971229
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	2.03e-06	2	50	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.03e-06	2	50	2	6881182
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	2.03e-06	2	50	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.03e-06	2	50	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.03e-06	2	50	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	2.03e-06	2	50	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	2.03e-06	2	50	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.03e-06	2	50	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.03e-06	2	50	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.03e-06	2	50	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.03e-06	2	50	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.03e-06	2	50	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	2.03e-06	2	50	2	1699796
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	2.03e-06	2	50	2	6978711
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	2.03e-06	2	50	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	2.03e-06	2	50	2	2997024
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.03e-06	2	50	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	2.03e-06	2	50	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	2.03e-06	2	50	2	3008092
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	2.03e-06	2	50	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	2.03e-06	2	50	2	3624865
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.03e-06	2	50	2	28873507
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.03e-06	2	50	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	2.03e-06	2	50	2	21857912
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	2.03e-06	2	50	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	2.03e-06	2	50	2	2900855
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.03e-06	2	50	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	2.03e-06	2	50	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	2.03e-06	2	50	2	4514997
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	2.03e-06	2	50	2	276882
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.03e-06	2	50	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	2.03e-06	2	50	2	5919331
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	2.03e-06	2	50	2	6832377
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	2.03e-06	2	50	2	3167981
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.03e-06	2	50	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	2.03e-06	2	50	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	2.03e-06	2	50	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	2.03e-06	2	50	2	3023818
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	2.03e-06	2	50	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	2.03e-06	2	50	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	2.03e-06	2	50	2	2572548
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.03e-06	2	50	2	22785613
Pubmed	The complement component C4 of mammals.	C4A C4B	2.03e-06	2	50	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	2.03e-06	2	50	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	2.03e-06	2	50	2	34358307
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.03e-06	2	50	2	32691186
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	2.03e-06	2	50	2	23259761
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	2.03e-06	2	50	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.03e-06	2	50	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	2.03e-06	2	50	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	2.03e-06	2	50	2	29080553
Pubmed	Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).	C4A C4B	2.03e-06	2	50	2	11168010
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	2.03e-06	2	50	2	8390682
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	2.03e-06	2	50	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	2.03e-06	2	50	2	6589636
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	2.03e-06	2	50	2	3902619
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	C4A C4B FGF17	5.54e-06	24	50	3	11739537
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.30e-04	9	35	2	1234
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 MAP3K9	9.78e-04	24	35	2	654
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	2.20e-03	36	35	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	2.32e-03	37	35	2	454
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB1 EDC3 COL5A3 C4B LRP1B	4.79e-07	138	50	5	c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB1 EDC3 COL5A3 C4B LRP1B	7.23e-07	150	50	5	afd651c654e715414eff64cf3a37378d057a56a2
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	EXD3 FBXO41 LGR6 EDNRB FGF17	2.97e-06	200	50	5	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB1 EDC3 C4B PMM1	1.96e-05	142	50	4	67d4ff3483ae34f77c3325aa0fbd3462ca19ade4
ToppCell	MS-CD8-exh_CD4\|MS / Condition, Cell_class and T cell subcluster	TRIM32 TMX4 LGR6 PMM1	1.96e-05	142	50	4	7591491520a883bb09fa2b8d0a20ae2abd2b8703
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP2 C4B LRP1B DNAH1	3.87e-05	169	50	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN4 PHLDB1 MRC2 COL5A3	4.53e-05	176	50	4	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN4 PHLDB1 MRC2 COL5A3	4.53e-05	176	50	4	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NTN4 UPK3B TMX4 C4B	4.84e-05	179	50	4	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TMX4 CNTNAP2 FBXO41 CNTNAP4	5.61e-05	186	50	4	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 COL5A3 C4B LGR6	5.97e-05	189	50	4	544d95df910f1b276995624509a7e41b219baca0
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	PHLDB1 MRC2 COL5A3 EDNRB	6.22e-05	191	50	4	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	NTN4 MRC2 COL5A3 HTRA4	6.22e-05	191	50	4	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN4 MFNG SLC16A9 EDNRB	6.35e-05	192	50	4	35f7926628a967f85b26371e795a1b93c6f103ab
ToppCell	Endothelial-Endothelial-B\|Endothelial / shred on cell class and cell subclass (v4)	NTN4 MFNG SLC16A9 EDNRB	6.35e-05	192	50	4	f8d7bd81e031d09a557722627c2f6180811cc6ab
ToppCell	Fibroblasts-CD55+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	NTN4 PHLDB1 MRC2 HTRA4	6.48e-05	193	50	4	8f4bf9a2fbedae35432dad96730b00c70185874c
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	PHLDB1 MRC2 COL5A3 EDNRB	6.48e-05	193	50	4	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 TM9SF2 SLC16A9 EDNRB	6.74e-05	195	50	4	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	CMIP CNTNAP2 TMEM238 LRP1B	7.44e-05	200	50	4	a3fcd901cb281920f1bafdfd676399a6dc37355e
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP2 CNTNAP4	6.62e-05	8	46	2	DOID:0060308 (implicated_via_orthology)
Disease	lysophosphatidylcholine 15:0 measurement	FBXO41 LRP1B	2.14e-04	14	46	2	EFO_0020941
Disease	Complement deficiency disease	C4A C4B	1.22e-03	33	46	2	C0272242
Disease	Polynesian Bronchiectasis	MCIDAS DNAH1	1.37e-03	35	46	2	C4317124
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	MCIDAS DNAH1	1.37e-03	35	46	2	C4551906
Disease	Kartagener Syndrome	MCIDAS DNAH1	1.37e-03	35	46	2	C0022521
Disease	Graves' disease (is_implicated_in)	C4A C4B	1.70e-03	39	46	2	DOID:12361 (is_implicated_in)
Disease	autism spectrum disorder (implicated_via_orthology)	TAOK2 CNTNAP2 CNTNAP4	1.73e-03	152	46	3	DOID:0060041 (implicated_via_orthology)
Disease	autistic disorder (is_implicated_in)	CNTNAP2 C4B	1.97e-03	42	46	2	DOID:12849 (is_implicated_in)
Disease	Autoimmune Diseases	CXCR3 C4B	1.97e-03	42	46	2	C0004364
Disease	systemic lupus erythematosus (implicated_via_orthology)	C4A C4B	2.06e-03	43	46	2	DOID:9074 (implicated_via_orthology)
Disease	pneumonia	EXD3 TM9SF2	2.46e-03	47	46	2	EFO_0003106
Disease	Primary Ciliary Dyskinesia	MCIDAS DNAH1	2.46e-03	47	46	2	C4551720

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLLLRLGCPNQRGLQ	CXCR3	331	P49682
ASLLRLPRGCGEQTM	C4B	1001	P0C0L5
GAVPCRRALLLCNGM	CMIP	36	Q8IY22
ENKLGPCMLLALRGN	CMIP	566	Q8IY22
RGFLGCIRSLQLNGM	CNTNAP4	926	Q9C0A0
CMRNGPNILIASLAL	EDNRB	131	P24530
GQEAGLLPRVMCRLQ	POLM	341	Q9NP87
MGAARLLPNLTLCLQ	FGF17	1	O60258
LQLCQRTMALPVGRG	ANAPC1	1071	Q9H1A4
ALALNILACGSLMRP	SLC16A9	176	Q7RTY1
GQLNGPNCTRLLTNM	LRP1B	4011	Q9NZR2
TRAGIRLLPSGMCQQ	LGR6	336	Q9HBX8
SQALMRLIGCPLCRG	GPC2	251	Q8N158
MAAQPPRGIRLSALC	MORC3	1	Q14149
SRNRLFNLGTMQCLG	MRC2	81	Q9UBG0
LLGGRALMNCLPSNR	LRRC45	186	Q96CN5
CASQMALTLLGGPNR	EDC3	311	Q96F86
SICPNRMLALPGRAL	MCIDAS	16	D6RGH6
MTNCLSFRNGRGLAL	PCDHGA3	1	Q9Y5H0
GEVCRGPRMSQNLLR	DNAH1	111	Q9P2D7
MIRPQLRTAGLGRCL	HTRA4	1	P83105
IRGGLSNMLFQCSLP	CHKA	116	P35790
GVQGLASLARNCMRL	FBXO41	756	Q8TF61
MQAAPRAGCGAALLL	CNTNAP2	1	Q9UHC6
MGNRRDLGQPRAGLC	COL5A3	1	P25940
LCLVMEFARGGPLNR	MAP3K9	216	P80192
ASLLRLPRGCGEQTM	C4A	1001	P0C0L4
MQCRLPRGLAGALLT	MFNG	1	O00587
MLSSCIRNQLGGPFL	HEXA-AS1	106	Q9H8Q6
PACVLQMRGLGALLL	PIDD1	141	Q9HB75
GLLMCRSCGRRLPRQ	TRIM32	96	Q13049
EKACNPRMGNLALGR	NTN4	31	Q9HB63
RLSPMAFRALQGCGA	TAOK2	1091	Q9UL54
FRNGMLNISPIGRSC	PMM1	131	Q92871
CRGPLAMGLAQPRLL	REPIN1	6	Q9BWE0
LALSPDLQAARGLMC	CLDN8	71	P56748
QRHLSNPARPGMLCG	PRSS53	196	Q2L4Q9
QRMLLSLRLSDCGLG	PDCD11	791	Q14690
CLANLRPLLDSGTMG	UBA6	581	A0AVT1
MAGGRCGPQLTALLA	TMX4	1	Q9H1E5
ERPSMQLLGLFRCEG	TEP1	2581	Q99973
CCLLPAPGRRRMNQG	RNF112	356	Q9ULX5
RQPTRLTQGCMLCLG	PHLDB1	111	Q86UU1
MRGQRSLLLGPARLC	ZDHHC16	1	Q969W1
LRSLSGDLNRFPCGM	ZNF839	721	A8K0R7
ACLGFLSPANRGALM	TM9SF2	386	Q99805
APAAGLGRCRMALLL	TMEM238	26	C9JI98
GLQMLLLALNCLRPS	UPK3B	11	Q9BT76
MAGGVLPLRGLRALC	TM2D3	1	Q9BRN9
NMLQGLARSLRCLGV	EXD3	636	Q8N9H8
MAAPCLLRQGRAGAL	NDUFV3	1	P56181