Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannan binding	FCN1 FCN2	1.29e-05	3	42	2	GO:2001065
GeneOntologyBiologicalProcess	complement activation	C2 SUSD4 FCN1 FCN2	1.12e-05	70	41	4	GO:0006956
GeneOntologyBiologicalProcess	male meiosis chromosome segregation	M1AP TEX11	2.31e-05	4	41	2	GO:0007060
GeneOntologyBiologicalProcess	recognition of apoptotic cell	FCN1 FCN2	8.04e-05	7	41	2	GO:0043654
GeneOntologyBiologicalProcess	apoptotic cell clearance	C2 FCN1 FCN2	1.18e-04	48	41	3	GO:0043277
GeneOntologyBiologicalProcess	positive regulation of opsonization	FCN1 FCN2	1.38e-04	9	41	2	GO:1903028
GeneOntologyBiologicalProcess	meiosis I	M1AP UBR2 TEX11 EHMT2	2.04e-04	147	41	4	GO:0007127
GeneOntologyBiologicalProcess	regulation of opsonization	FCN1 FCN2	2.10e-04	11	41	2	GO:1903027
GeneOntologyBiologicalProcess	male meiotic nuclear division	M1AP UBR2 TEX11	2.31e-04	60	41	3	GO:0007140
GeneOntologyBiologicalProcess	meiosis I cell cycle process	M1AP UBR2 TEX11 EHMT2	2.50e-04	155	41	4	GO:0061982
GeneOntologyBiologicalProcess	complement activation, lectin pathway	FCN1 FCN2	2.51e-04	12	41	2	GO:0001867
GeneOntologyBiologicalProcess	protein polyubiquitination	TCF25 UBR2 TRAF6 SYVN1 TRIP12	2.59e-04	289	41	5	GO:0000209
GeneOntologyBiologicalProcess	regulation of innate immune response	RAET1L TRAF6 SUSD4 USP38 FCN1 FCN2	5.25e-04	519	41	6	GO:0045088
GeneOntologyBiologicalProcess	opsonization	FCN1 FCN2	6.45e-04	19	41	2	GO:0008228
GeneOntologyBiologicalProcess	nuclear chromosome segregation	M1AP DIS3L2 TEX11 NEK6 EHMT2	6.70e-04	356	41	5	GO:0098813
GeneOntologyBiologicalProcess	cell surface pattern recognition receptor signaling pathway	TRAF6 FCN1 FCN2	6.88e-04	87	41	3	GO:0002752
MousePheno	abnormal complement pathway	SUSD4 FCN1 FCN2	3.00e-05	26	33	3	MP:0002471
MousePheno	impaired lectin complement pathway	FCN1 FCN2	3.23e-05	4	33	2	MP:0009062
Domain	NUT	NUTM2B NUTM2A	4.45e-05	5	40	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	4.45e-05	5	40	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	4.45e-05	5	40	2	PF12881
Domain	Fibrinogen_CS	FCN1 FCN2	7.47e-04	19	40	2	IPR020837
Domain	-	FCN1 FCN2	1.20e-03	24	40	2	4.10.530.10
Domain	Fibrinogen_a/b/g_C_2	FCN1 FCN2	1.20e-03	24	40	2	IPR014715
Domain	Fibrinogen_C	FCN1 FCN2	1.52e-03	27	40	2	PF00147
Domain	FBG	FCN1 FCN2	1.75e-03	29	40	2	SM00186
Domain	-	FCN1 FCN2	1.87e-03	30	40	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	FCN1 FCN2	1.87e-03	30	40	2	IPR014716
Domain	Fibrinogen_a/b/g_C_dom	FCN1 FCN2	2.13e-03	32	40	2	IPR002181
Domain	FIBRINOGEN_C_2	FCN1 FCN2	2.13e-03	32	40	2	PS51406
Domain	FIBRINOGEN_C_1	FCN1 FCN2	2.13e-03	32	40	2	PS00514
Domain	Sugar_tr	SLC22A14 SLC22A17	2.69e-03	36	40	2	PF00083
Domain	MFS_sugar_transport-like	SLC22A14 SLC22A17	2.69e-03	36	40	2	IPR005828
Domain	Sushi	C2 SUSD4	5.54e-03	52	40	2	PF00084
Domain	CCP	C2 SUSD4	5.97e-03	54	40	2	SM00032
Domain	SUSHI	C2 SUSD4	6.40e-03	56	40	2	PS50923
Domain	Sushi_SCR_CCP_dom	C2 SUSD4	6.63e-03	57	40	2	IPR000436
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C2 FCN1 FCN2	1.02e-06	11	27	3	M47874
Pathway	REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE	FCN1 FCN2	3.52e-05	5	27	2	M27204
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	C2 SUSD4 FCN1 FCN2	4.64e-05	106	27	4	M42535
Pathway	KEGG_MEDICUS_PATHOGEN_SARS_COV_2_S_N_TO_LECTIN_PATHWAY_OF_COAGULATION_CASCADE	FCN1 FCN2	5.27e-05	6	27	2	M47785
Pathway	REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION	FCN1 FCN2	7.38e-05	7	27	2	MM14654
Pathway	REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION	FCN1 FCN2	9.82e-05	8	27	2	M27005
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_PROTHROMBIN_TO_THROMBIN	FCN1 FCN2	9.82e-05	8	27	2	M47784
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	C2 FCN1 FCN2	1.46e-04	54	27	3	MM14655
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_FIBRINOGEN_TO_FIBRIN	FCN1 FCN2	1.57e-04	10	27	2	M47879
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	C2 FCN1 FCN2	4.67e-04	80	27	3	M6121
Pathway	REACTOME_COMPLEMENT_CASCADE	C2 FCN1 FCN2	5.38e-04	84	27	3	MM14653
Pathway	WP_COMPLEMENT_SYSTEM	C2 FCN1 FCN2	7.95e-04	96	27	3	M39581
Pathway	REACTOME_COMPLEMENT_CASCADE	C2 FCN1 FCN2	1.34e-03	115	27	3	M19752
Pubmed	Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1.	FCN1 FCN2	1.49e-06	2	43	2	38750493
Pubmed	The interaction pattern of murine serum ficolin-A with microorganisms.	FCN1 FCN2	1.49e-06	2	43	2	22666482
Pubmed	Immature mouse granulocytic myeloid cells are characterized by production of ficolin-B.	FCN1 FCN2	1.49e-06	2	43	2	23911405
Pubmed	Purification and binding properties of a human ficolin-like protein.	FCN1 FCN2	1.49e-06	2	43	2	9202708
Pubmed	Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.	FCN1 FCN2	1.49e-06	2	43	2	23150716
Pubmed	A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin.	FCN1 FCN2	1.49e-06	2	43	2	8576206
Pubmed	Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells.	FCN1 FCN2	1.49e-06	2	43	2	28844702
Pubmed	L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo.	FCN1 FCN2	1.49e-06	2	43	2	22399010
Pubmed	Functional analysis of mouse ficolin-B and detection in neutrophils.	FCN1 FCN2	1.49e-06	2	43	2	22459270
Pubmed	Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway.	FCN1 FCN2	1.49e-06	2	43	2	22523468
Pubmed	Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.	FCN1 FCN2	1.49e-06	2	43	2	24040095
Pubmed	Molecular cloning and characterization of mouse ficolin-A.	FCN1 FCN2	1.49e-06	2	43	2	9535745
Pubmed	Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.	FCN1 FCN2	1.49e-06	2	43	2	27467404
Pubmed	FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway.	FCN1 FCN2	1.49e-06	2	43	2	32272397
Pubmed	Identification of a functionally relevant signal peptide of mouse ficolin A.	FCN1 FCN2	1.49e-06	2	43	2	17669269
Pubmed	The ficolin response to LPS challenge in mice.	FCN1 FCN2	1.49e-06	2	43	2	30818229
Pubmed	Ficolins and the fibrinogen-like domain.	FCN1 FCN2	1.49e-06	2	43	2	9777405
Pubmed	Cloning and characterization of the human lectin P35 gene and its related gene.	FCN1 FCN2	1.49e-06	2	43	2	8884275
Pubmed	Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.	FCN1 FCN2	1.49e-06	2	43	2	37356123
Pubmed	Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus.	FCN1 FCN2	4.48e-06	3	43	2	25069872
Pubmed	Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.	FCN1 FCN2	4.48e-06	3	43	2	32601370
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	4.48e-06	3	43	2	22456610
Pubmed	Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis.	FCN1 FCN2	4.48e-06	3	43	2	18032536
Pubmed	Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus.	FCN1 FCN2	4.48e-06	3	43	2	27981461
Pubmed	Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38.	TRAF6 USP38	4.48e-06	3	43	2	35238669
Pubmed	Ficolin-A/2 Aggravates Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D-Induced Pyroptosis.	FCN1 FCN2	4.48e-06	3	43	2	38442803
Pubmed	M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.	FCN1 FCN2	4.48e-06	3	43	2	21490156
Pubmed	Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation.	FCN1 FCN2	4.48e-06	3	43	2	15804047
Pubmed	Oligomeric structure and tissue distribution of ficolins from mouse, pig and human.	FCN1 FCN2	4.48e-06	3	43	2	9851834
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	4.48e-06	3	43	2	26542179
Pubmed	Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.	FCN1 FCN2	4.48e-06	3	43	2	16328467
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	TRAF6 SYVN1 TRIP12	5.64e-06	28	43	3	35474067
Pubmed	Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.	FCN1 FCN2	8.94e-06	4	43	2	19632990
Pubmed	Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.	FCN1 FCN2	8.94e-06	4	43	2	28739878
Pubmed	Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis.	FCN1 FCN2	8.94e-06	4	43	2	28380665
Pubmed	Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.	FCN1 FCN2	8.94e-06	4	43	2	10679061
Pubmed	Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species.	FCN1 FCN2	8.94e-06	4	43	2	23478320
Pubmed	Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins.	FCN1 FCN2	8.94e-06	4	43	2	15475251
Pubmed	Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.	FCN1 FCN2	8.94e-06	4	43	2	20375621
Pubmed	Mycobacterial antigen 85 complex (Ag85) as a target for ficolins and mannose-binding lectin.	FCN1 FCN2	1.49e-05	5	43	2	27141819
Pubmed	Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.	FCN1 FCN2	2.23e-05	6	43	2	15950722
Pubmed	The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.	FCN1 FCN2	3.12e-05	7	43	2	22792067
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	NECAB3 RAET1L TRAF6 SUSD4 FCRL1 FCN1 FCN2	6.26e-05	824	43	7	20237496
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	FCN1 FCN2	6.68e-05	10	43	2	21943708
Pubmed	Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.	NOX4 TRAF6	8.15e-05	11	43	2	30755476
Pubmed	M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.	M1AP TEX11	1.15e-04	13	43	2	36440627
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 TRAF6 TRIP12	2.25e-04	95	43	3	29643511
Pubmed	Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.	TREX2 SYVN1 INTS2 C3orf20 PARP8	4.53e-04	523	43	5	11256614
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	UBR2 SYVN1 MRS2 ZZEF1 ARMC8	4.94e-04	533	43	5	25544563
Pubmed	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	NOX4 TRAF6 PIK3R5	7.15e-04	141	43	3	20056178
Pubmed	Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.	FCN1 FCN2	7.23e-04	32	43	2	9611252
Pubmed	The genetic architecture of economic and political preferences.	C2 EHMT2	9.67e-04	37	43	2	22566634
Pubmed	MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.	SYVN1 USP38	1.13e-03	40	43	2	30759391
Interaction	FCN2 interactions	FCN1 FCN2	2.42e-05	4	41	2	int:FCN2
Interaction	SERINC5 interactions	TRAF6 SYVN1 TRIP12	3.72e-05	32	41	3	int:SERINC5
Cytoband	10q22.3	NUTM2E NUTM2B	7.55e-04	43	43	2	10q22.3
Cytoband	3p21.3	SLC22A14 TMEM158	1.42e-03	59	43	2	3p21.3
GeneFamily	Fibrinogen C domain containing	FCN1 FCN2	5.85e-04	25	26	2	554
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	C2 SUSD4	3.02e-03	57	26	2	1179
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	1.70e-05	5	39	2	C0206630
Disease	ficolin-2 measurement	FCN1 FCN2	1.70e-05	5	39	2	EFO_0008135
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	2.54e-05	6	39	2	C0334488
Disease	ficolin-1 measurement	FCN1 FCN2	2.54e-05	6	39	2	EFO_0008134

Protein segments in the cluster

Peptide	Gene	Start	Entry
EELPLCSCRMEAPKI	EHMT2	421	Q96KQ7
VRPGCRELLCLLMIT	AMIGO2	16	Q86SJ2
VPMLPRLLCEELCSL	DIS3L2	441	Q8IYB7
LALPPALETARALMC	CLDN17	71	P56750
APASACLLLMLLALP	RTN4RL2	11	Q86UN3
GPMLRPTVCERELCV	PARP8	521	Q8N3A8
PMCLKCDLQERLLCP	M1AP	256	Q8TC57
CLPCTMEANLALRRP	C2	581	P06681
MDINAVLCCPPIALR	CD200R1L	46	Q6Q8B3
ELRLLLPCLVRMALC	INTS2	41	Q9H0H0
LPCLVRMALCAPADQ	INTS2	46	Q9H0H0
MECLRSLPCLLPRAM	MRS2	1	Q9HD23
EKLRELVSMCICPDP	NEK6	276	Q9HC98
MDAPARLLAPLLLLC	GABRD	1	O14764
LNCSLILLPMCRTLL	NOX4	66	Q9NPH5
LPDCRPLTVLCDMDT	FCN1	136	O00602
LPCLVRMCSKERLLE	ARMC8	281	Q8IUR7
IYLPDCRPLTVLCDM	FCN2	121	Q15485
MLPRLLLLICAPLCE	FCRL1	1	Q96LA6
ALPSDCPLVLRKLML	C3orf20	661	Q8ND61
PSIMEVPARLCCIFL	SLC22A14	416	Q9Y267
MDKSLLLELPILLCC	PATE1	1	Q8WXA2
LPLPLCRMSGVLCSR	NUTM2A	61	Q8IVF1
LPLPLCRMSGVLCSR	NUTM2B	61	A6NNL0
LPLPLCRMSGVLCSR	NUTM2E	61	B1AL46
CPTCRMDVLRASLPA	SYVN1	326	Q86TM6
ACALLCILSIMLLPE	SLC22A17	481	Q8WUG5
CLMVALCSPSIPLEK	VWC2	21	Q2TAL6
MAPARAGCCPLLLLL	RNASE8	1	Q8TDE3
APDLCSLLCLPIMTF	PIK3R5	861	Q8WYR1
MLPLLAALLAAACPL	TMEM158	1	Q8WZ71
CLDCYMDPLRLSLLP	TINF2	356	Q9BSI4
PICLMALREAVQTPC	TRAF6	71	Q9Y4K3
RCLALEVCPLPPMVS	SUSD4	236	Q5VX71
CLLRFLLPKIAEMPE	TEX11	581	Q8IYF3
MAAAAIPALLLCLPL	RAET1L	1	Q5VY80
VLRMVCERPEPQLCA	USP38	131	Q8NB14
LCLLILDPGCPSREM	ZUP1	506	Q96AP4
MIILPCLSRPARCDQ	ZZEF1	2541	O43149
LVLPRVLDKLTLCMC	TREX2	51	Q9BQ50
VLDKLTLCMCPERPF	TREX2	56	Q9BQ50
ELTSLICELMPCLPK	TRIP12	726	Q14669
PMLIEHPLRCLVLCA	UBR2	646	Q8IWV8
LSLEPDEDPLCMLLL	TCF25	371	Q9BQ70
MACAGLLTVCLLRPP	NECAB3	1	Q96P71