Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin DNA binding	FOXO1 TOX4 ACTL6A KDM6B ZFX	1.34e-04	167	59	5	GO:0031490
Domain	Teashirt_fam	TSHZ3 TSHZ2 TSHZ1	2.70e-08	3	57	3	IPR027008
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	5.81e-06	12	57	3	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	5.81e-06	12	57	3	IPR027970
Domain	Gamma_tubulin	TUBG2 TUBG1	9.15e-06	2	57	2	IPR002454
Domain	-	TUBG2 TUBG1	1.68e-03	20	57	2	3.30.1330.20
Domain	-	TUBG2 TUBG1	1.85e-03	21	57	2	1.10.287.600
Domain	Tubulin_C	TUBG2 TUBG1	2.03e-03	22	57	2	SM00865
Domain	Tubulin_C	TUBG2 TUBG1	2.03e-03	22	57	2	PF03953
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBG2 TUBG1	2.03e-03	22	57	2	IPR018316
Domain	-	TUBG2 TUBG1	2.03e-03	22	57	2	3.40.50.1440
Domain	Tubulin_C	TUBG2 TUBG1	2.22e-03	23	57	2	IPR023123
Domain	TUBULIN	TUBG2 TUBG1	2.22e-03	23	57	2	PS00227
Domain	Tubulin	TUBG2 TUBG1	2.22e-03	23	57	2	IPR000217
Domain	Tub_FtsZ_C	TUBG2 TUBG1	2.22e-03	23	57	2	IPR008280
Domain	Tubulin	TUBG2 TUBG1	2.22e-03	23	57	2	SM00864
Domain	Tubulin_CS	TUBG2 TUBG1	2.22e-03	23	57	2	IPR017975
Domain	Tubulin_FtsZ_GTPase	TUBG2 TUBG1	2.42e-03	24	57	2	IPR003008
Domain	Tubulin	TUBG2 TUBG1	2.42e-03	24	57	2	PF00091
Domain	DHHC	KMT2C ZDHHC8	2.62e-03	25	57	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	KMT2C ZDHHC8	2.62e-03	25	57	2	IPR001594
Pathway	WP_KLEEFSTRA_SYNDROME	KMT2C ACTL6A NR1I3	1.27e-04	29	48	3	M48076
Pathway	WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY	FOXO1 ABCC2 NR1I3	1.56e-04	31	48	3	M39476
Pubmed	Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.	TSHZ3 TSHZ2 TSHZ1	4.64e-09	3	59	3	16631416
Pubmed	Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.	TSHZ3 TSHZ2 TSHZ1	4.64e-09	3	59	3	19745106
Pubmed	Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.	TSHZ3 TSHZ2 TSHZ1	4.64e-09	3	59	3	14973285
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 KMT2C PUF60 INTS1 CFAP43 TXNRD2 MED13L KDM6B ZDHHC8 ABTB2 TUBG1 TOP3A RYR1	3.27e-08	1105	59	13	35748872
Pubmed	FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.	TSHZ3 TSHZ2 TSHZ1	1.62e-07	7	59	3	19343227
Pubmed	Rack1 regulates cellular patterning and polarity in the mouse cochlea.	TUBG2 FZD3 TUBG1	2.58e-07	8	59	3	36252648
Pubmed	Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.	TSHZ3 TSHZ2 TSHZ1	2.58e-07	8	59	3	15834955
Pubmed	Ciliary proteins link basal body polarization to planar cell polarity regulation.	TUBG2 FZD3 TUBG1	3.87e-07	9	59	3	18066062
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	TUBG2 FZD3 TUBG1	7.58e-07	11	59	3	25024228
Pubmed	The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.	TUBG2 DYNC2H1 TUBG1	7.58e-07	11	59	3	28291807
Pubmed	Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin.	TUBG2 FZD3 TUBG1	1.01e-06	12	59	3	22318628
Pubmed	A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.	NPHS1 TUBG2 TUBG1	1.31e-06	13	59	3	26859289
Pubmed	Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.	TUBG2 TUBG1	2.83e-06	2	59	2	28119396
Pubmed	Expression and regulation of mouse Mtsh1 during limb and branchial arch development.	TSHZ2 TSHZ1	2.83e-06	2	59	2	11668608
Pubmed	Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers.	TSHZ3 TSHZ2	2.83e-06	2	59	2	21423795
Pubmed	MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.	TUBG2 TUBG1	2.83e-06	2	59	2	17442887
Pubmed	Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt.	TSHZ2 TSHZ1	2.83e-06	2	59	2	10704881
Pubmed	Overexpression of γ-tubulin in non-small cell lung cancer.	TUBG2 TUBG1	2.83e-06	2	59	2	22806905
Pubmed	Gene knockout analysis of two gamma-tubulin isoforms in mice.	TUBG2 TUBG1	2.83e-06	2	59	2	15893303
Pubmed	Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.	TUBG2 TUBG1	2.83e-06	2	59	2	17287496
Pubmed	KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer.	FOXO1 KDM6B	2.83e-06	2	59	2	26303949
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	TUBG2 DYNC2H1 TUBG1	3.10e-06	17	59	3	22357932
Pubmed	Cilia and Hedgehog responsiveness in the mouse.	TUBG2 DYNC2H1 TUBG1	4.41e-06	19	59	3	16061793
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	TUBG2 DYNC2H1 TUBG1	6.03e-06	21	59	3	22007132
Pubmed	The gamma-tubulin gene family in humans.	TUBG2 TUBG1	8.48e-06	3	59	2	10903841
Pubmed	Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.	FOXO1 NR1I3	8.48e-06	3	59	2	15340055
Pubmed	Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.	TUBG2 TUBG1	8.48e-06	3	59	2	27015882
Pubmed	Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.	TUBG2 TUBG1	8.48e-06	3	59	2	9566969
Pubmed	The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.	TUBG2 TUBG1	8.48e-06	3	59	2	26021315
Pubmed	CAR-mediated repression of Cdkn1a(p21) is accompanied by the Akt activation.	FOXO1 NR1I3	8.48e-06	3	59	2	29890134
Pubmed	Multimodal Hox5 activity generates motor neuron diversity.	TSHZ3 TSHZ2 TSHZ1	1.64e-05	29	59	3	39289460
Pubmed	TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.	FOXO1 TOX4	1.69e-05	4	59	2	34914893
Pubmed	Loss of Necdin impairs myosin activation and delays cell polarization.	TUBG2 TUBG1	1.69e-05	4	59	2	20665884
Pubmed	Cilia organize ependymal planar polarity.	TUBG2 TUBG1	1.69e-05	4	59	2	20164345
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	TUBG2 TUBG1	1.69e-05	4	59	2	36574677
Pubmed	Obesity-related genetic polymorphisms and adiposity indices in a young Italian population.	MC4R ACE	1.69e-05	4	59	2	28090739
Pubmed	Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.	TUBG2 TUBG1	1.69e-05	4	59	2	16798874
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	NPHS1 TSHZ3 TSHZ2 TSHZ1	2.12e-05	95	59	4	20843830
Pubmed	Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.	TUBG2 TUBG1	2.82e-05	5	59	2	21285373
Pubmed	Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.	TUBG2 TUBG1	2.82e-05	5	59	2	29244804
Pubmed	Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.	TUBG2 TUBG1	2.82e-05	5	59	2	31390572
Pubmed	A two-kinesin mechanism controls neurogenesis in the developing brain.	TUBG2 TUBG1	2.82e-05	5	59	2	38040957
Pubmed	Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.	TUBG2 TUBG1	2.82e-05	5	59	2	16751367
Pubmed	A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.	TUBG2 TUBG1	2.82e-05	5	59	2	15680357
Pubmed	Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.	TUBG2 TUBG1	2.82e-05	5	59	2	19251731
Pubmed	The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.	TUBG2 TUBG1	2.82e-05	5	59	2	21529752
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	TUBG2 TUBG1	2.82e-05	5	59	2	18729223
Pubmed	WDR62 is associated with the spindle pole and is mutated in human microcephaly.	TUBG2 TUBG1	2.82e-05	5	59	2	20890279
Pubmed	Speriolin is a novel human and mouse sperm centrosome protein.	TUBG2 TUBG1	2.82e-05	5	59	2	20542897
Pubmed	Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.	TUBG2 TUBG1	2.82e-05	5	59	2	25877302
Pubmed	Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes.	NPHS1 FZD3	2.82e-05	5	59	2	23824190
Pubmed	HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.	TUBG2 TUBG1	2.82e-05	5	59	2	14767062
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	EPRS1 PUF60 GNPTAB ELOVL1 ABCC2 MED13L PLCH1 RYR1	3.19e-05	732	59	8	34732716
Pubmed	The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.	TUBG2 TUBG1	4.23e-05	6	59	2	38546045
Pubmed	Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.	TUBG2 TUBG1	4.23e-05	6	59	2	30970247
Pubmed	Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.	TUBG2 TUBG1	4.23e-05	6	59	2	35259752
Pubmed	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.	TUBG2 TUBG1	4.23e-05	6	59	2	22842144
Pubmed	Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.	TUBG2 TUBG1	4.23e-05	6	59	2	29229864
Pubmed	Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.	TUBG2 TUBG1	4.23e-05	6	59	2	10840040
Pubmed	CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.	TUBG2 TUBG1	4.23e-05	6	59	2	36334595
Pubmed	A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.	TUBG2 TUBG1	4.23e-05	6	59	2	11237715
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	TUBG2 DYNC2H1 TUBG1	4.38e-05	40	59	3	32317081
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	TAOK2 KMT2C RAP1GAP POLR1A BPI ERAP1 GNPTAB ELOVL1 RYR1 ZFX	5.83e-05	1293	59	10	15342556
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	CARM1 KMT2C KDM6B	5.84e-05	44	59	3	24183668
Pubmed	HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.	TUBG2 TUBG1	5.91e-05	7	59	2	29724823
Pubmed	Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.	TUBG2 TUBG1	5.91e-05	7	59	2	22902295
Pubmed	Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.	ABCC2 NR1I3	5.91e-05	7	59	2	18294295
Pubmed	PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.	TUBG2 TUBG1	5.91e-05	7	59	2	38827526
Pubmed	Mammalian RanBP1 regulates centrosome cohesion during mitosis.	TUBG2 TUBG1	5.91e-05	7	59	2	12840069
Pubmed	AIRE is a critical spindle-associated protein in embryonic stem cells.	TUBG2 TUBG1	5.91e-05	7	59	2	28742026
Pubmed	Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients.	NPHS1 ACE	5.91e-05	7	59	2	19520069
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	TUBG2 TUBG1	5.91e-05	7	59	2	38261656
Pubmed	The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.	TUBG2 TUBG1	5.91e-05	7	59	2	29372668
Pubmed	A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.	TUBG2 TUBG1	5.91e-05	7	59	2	30289203
Pubmed	Pax6 controls centriole maturation in cortical progenitors through Odf2.	TUBG2 TUBG1	5.91e-05	7	59	2	25352170
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	CARM1 EEFSEC EPRS1 POLR1A PUF60 ACTL6A TUBG1	6.96e-05	601	59	7	33658012
Pubmed	A ciliopathy complex builds distal appendages to initiate ciliogenesis.	TUBG2 TUBG1	7.87e-05	8	59	2	34241634
Pubmed	Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.	TUBG2 TUBG1	7.87e-05	8	59	2	27727273
Pubmed	A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.	TUBG2 TUBG1	7.87e-05	8	59	2	17908927
Pubmed	The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.	TUBG2 TUBG1	7.87e-05	8	59	2	19112494
Pubmed	Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.	TUBG2 TUBG1	7.87e-05	8	59	2	26540106
Pubmed	Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.	MED13L ZFX	7.87e-05	8	59	2	27365365
Pubmed	A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development.	TUBG2 TUBG1	7.87e-05	8	59	2	15958512
Pubmed	Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.	TUBG2 TUBG1	7.87e-05	8	59	2	18239929
Pubmed	The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors.	TUBG2 TUBG1	7.87e-05	8	59	2	38086550
Pubmed	ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.	TUBG2 TUBG1	7.87e-05	8	59	2	27562601
Pubmed	Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.	FOXO1 MC4R ACE	9.11e-05	51	59	3	20682687
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EEFSEC EPRS1 KMT2C PUF60 PPME1 ACTL6A MED13L TUBG1 GSN	9.49e-05	1103	59	9	34189442
Pubmed	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	FZD3 ACE ZDHHC8	9.66e-05	52	59	3	18583979
Pubmed	TRIP6 functions in brain ciliogenesis.	TUBG2 TUBG1	1.01e-04	9	59	2	34620853
Pubmed	Centriolar Protein C2cd3 Is Required for Craniofacial Development.	TUBG2 TUBG1	1.01e-04	9	59	2	34211969
Pubmed	Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.	TUBG2 TUBG1	1.01e-04	9	59	2	11956313
Pubmed	Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.	TUBG2 TUBG1	1.01e-04	9	59	2	8838651
Pubmed	Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.	TUBG2 TUBG1	1.01e-04	9	59	2	30532139
Pubmed	TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.	TUBG2 TUBG1	1.01e-04	9	59	2	31086189
Pubmed	Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus.	TUBG2 TUBG1	1.01e-04	9	59	2	14667810
Pubmed	Autonomous and non-cell autonomous role of cilia in structural birth defects in mice.	TUBG2 TUBG1	1.01e-04	9	59	2	38079449
Pubmed	Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.	CARM1 ACTL6A	1.01e-04	9	59	2	14966289
Pubmed	MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.	TUBG2 TUBG1	1.01e-04	9	59	2	21397847
Pubmed	Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.	TUBG2 TUBG1	1.01e-04	9	59	2	30824354
Interaction	TSHZ1 interactions	TSHZ3 TSHZ2 TSHZ1	9.03e-06	15	56	3	int:TSHZ1
Cytoband	9q21.32	SPATA31D4 SPATA31D1 SPATA31D3	1.93e-06	19	59	3	9q21.32
Cytoband	19q13.1	NPHS1 CATSPERG RYR1	5.04e-05	55	59	3	19q13.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 TSHZ2 TSHZ1	6.86e-06	15	46	3	529
Coexpression	GSE10273_HIGH_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_DN	CARM1 FOXO1 PUF60 INTS1 ABTB2 GSN	4.33e-06	200	56	6	M317
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Nnat_(Presubiculum,_Col5a2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NPHS1 ODF4 CATSPERG NR1I3	2.43e-06	71	59	4	3f7ab70a5451043019f6e56c16ab95182ff44a15
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Nnat_(Presubiculum,_Col5a2+)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NPHS1 ODF4 CATSPERG NR1I3	2.43e-06	71	59	4	f0af76191cb0e29abf6e7d1a6f5a0df1ad837ce7
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARM1 TSHZ3 ERAP1 PPME1 TXNRD2	2.58e-06	164	59	5	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARM1 TSHZ3 ERAP1 PPME1 TXNRD2	2.58e-06	164	59	5	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	FOXO1 TSHZ2 DYNC2H1 ABTB2 GSN	5.58e-06	192	59	5	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	FOXO1 TSHZ2 DYNC2H1 ABTB2 GSN	5.72e-06	193	59	5	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 DYNC2H1 ABTB2 GSN	6.01e-06	195	59	5	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	7.44e-05	169	59	4	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	RAP1GAP GLYCTK CFAP43 PLCH1	7.61e-05	170	59	4	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	droplet-Fat-Bat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUBG2 INTS1 TXNRD2 ZDHHC8	7.61e-05	170	59	4	c720d81bc29a8fd1f1249c6af408471d561f1d5d
ToppCell	droplet-Fat-Bat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUBG2 INTS1 TXNRD2 ZDHHC8	7.61e-05	170	59	4	c4ecdfc2b4710da0a5fbb20e9df02536023badb1
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSHZ2 PUF60 INTS1 PDP2	7.61e-05	170	59	4	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTNA PPME1 TXNRD2 ZDHHC8	8.52e-05	175	59	4	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTNA PPME1 TXNRD2 ZDHHC8	8.52e-05	175	59	4	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	NS-critical-d_0-4-Myeloid-Mast_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FZD3 OSBPL6 PPME1 ZDHHC8	9.29e-05	179	59	4	6153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	9.70e-05	181	59	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	URO-Lymphocyte-T_NK-dnT\|URO / Disease, Lineage and Cell Type	FOXO1 TSHZ1 TUBG1 TOP3A	9.91e-05	182	59	4	f2b1c524301d0f2d1b69c46f3653fd53c21c3aa0
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.10e-04	187	59	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 DYNC2H1 GSN	1.17e-04	190	59	4	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 DYNC2H1 GSN	1.19e-04	191	59	4	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	TSHZ3 TSHZ2 DYNC2H1 GSN	1.22e-04	192	59	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.27e-04	194	59	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.27e-04	194	59	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.27e-04	194	59	4	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 OSBPL6 CFAP43 PLCH1	1.29e-04	195	59	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DYNC2H1 OSBPL6 CFAP43 PLCH1	1.29e-04	195	59	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.29e-04	195	59	4	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DYNC2H1 OSBPL6 CFAP43 PLCH1	1.29e-04	195	59	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.29e-04	195	59	4	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO1 TSHZ2 ABTB2 GSN	1.32e-04	196	59	4	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 OSBPL6 CFAP43 PLCH1	1.34e-04	197	59	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	Sepsis-URO-Lymphocyte-T/NK-dn_T\|URO / Disease, condition lineage and cell class	FOXO1 TSHZ1 TUBG1 TOP3A	1.42e-04	200	59	4	04ea6381b93a5d8bbeda4d71c788d7fbac6d40bc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ZDHHC8 SLC25A37 RYR1 GSN	1.42e-04	200	59	4	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
Drug	5252917; Up 200; 14uM; MCF7; HT_HG-U133A_EA	FOXO1 DTNA MED13L PLCH1 SLC25A37 ABTB2	6.83e-06	185	57	6	944_UP
Drug	Oxybutynin chloride [1508-65-2]; Up 200; 10.2uM; PC3; HT_HG-U133A	FOXO1 OVGP1 ERAP1 DYNC2H1 DTNA ACE	1.01e-05	198	57	6	7126_UP
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; PC3; HT_HG-U133A	TOX4 DTNA PMEL ABCC2 PLCH1 TOP3A	1.01e-05	198	57	6	6332_UP
Drug	Clebopride maleate [84370-95-6]; Up 200; 8.2uM; MCF7; HT_HG-U133A	TAOK2 ERAP1 DTNA PMEL RYR1 ZFX	1.04e-05	199	57	6	5412_UP
Drug	4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline	FOXO1 NR1I3	6.13e-05	5	57	2	ctd:C000592353
Drug	2,4,6-triphenyl-1,3-dioxane	FOXO1 NR1I3	6.13e-05	5	57	2	ctd:C054589
Drug	AC1O528X	FOXO1 RYR1	9.18e-05	6	57	2	CID006475857
Drug	Clemastine fumarate [14976-57-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A	TUBG2 ERAP1 PLCH1 TOP3A ZFX	9.48e-05	183	57	5	7443_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; HL60; HT_HG-U133A	FOXO1 RAP1GAP FZD3 DYNC2H1 DTNA	1.08e-04	188	57	5	1150_UP
Drug	allodeoxycholic acid	EEFSEC PKN2 PLCH1 ACE RYR1	1.13e-04	190	57	5	CID000002987
Drug	yohimbine; Up 200; 22.9uM; MCF7; HT_HG-U133A_EA	RAP1GAP DTNA INTS1 KDM6B TOP3A	1.25e-04	194	57	5	1119_UP
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A	DTNA KDM6B SLC25A37 TOP3A ZFX	1.25e-04	194	57	5	4990_DN
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A	TAOK2 DTNA GNPTAB PLCH1 TOP3A	1.25e-04	194	57	5	6070_DN
Drug	Tetramisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A	ERAP1 PMEL PLCH1 KDM6B TOP3A	1.28e-04	195	57	5	4412_DN
Drug	Butoconazole nitrate [32872-77-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	TAOK2 DTNA PLCH1 KDM6B TOP3A	1.28e-04	195	57	5	5388_DN
Drug	Khellin [82-02-0]; Down 200; 15.4uM; HL60; HG-U133A	TAOK2 EPRS1 PPME1 MED13L SLC25A37	1.28e-04	195	57	5	2004_DN
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	TAOK2 DTNA PLCH1 KDM6B TOP3A	1.28e-04	195	57	5	3246_UP
Drug	Methimazole [60-56-0]; Up 200; 35uM; HL60; HT_HG-U133A	DYNC2H1 DTNA PLCH1 GSN ZFX	1.31e-04	196	57	5	2570_UP
Drug	Nimesulide [51803-78-2]; Down 200; 13uM; MCF7; HT_HG-U133A	DTNA PLCH1 SLC25A37 ABTB2 TOP3A	1.31e-04	196	57	5	7024_DN
Drug	Thiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT_HG-U133A	OVGP1 DTNA ABCC2 SLC25A37 TOP3A	1.31e-04	196	57	5	6232_UP
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	OVGP1 GNPTAB ABCC2 ABTB2 RYR1	1.31e-04	196	57	5	2888_DN
Drug	Benzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	EPRS1 ERAP1 GNPTAB ACE ZFX	1.31e-04	196	57	5	4294_UP
Drug	Miconazole [22916-47-8]; Up 200; 9.6uM; PC3; HT_HG-U133A	FOXO1 PLCH1 KDM6B TOP3A RYR1	1.31e-04	196	57	5	6615_UP
Drug	Cephalothin sodium salt [58-71-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TAOK2 OVGP1 DTNA PLCH1 TOP3A	1.34e-04	197	57	5	6819_DN
Drug	Pentolinium bitartrate [52-62-0]; Down 200; 7.4uM; HL60; HT_HG-U133A	BPI DTNA KDM6B SLC25A37 TOP3A	1.34e-04	197	57	5	2343_DN
Drug	Chlormezanone [80-77-3]; Down 200; 14.6uM; MCF7; HT_HG-U133A	DTNA PLCH1 SLC25A37 TOP3A ZFX	1.34e-04	197	57	5	5697_DN
Drug	Cortisone [53-06-5]; Down 200; 11uM; MCF7; HT_HG-U133A	TAOK2 RAP1GAP DYNC2H1 PLCH1 ABTB2	1.34e-04	197	57	5	7458_DN
Drug	Bergenin monohydrate [477-90-7]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TAOK2 FOXO1 DTNA KDM6B ABTB2	1.34e-04	197	57	5	3467_DN
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; PC3; HT_HG-U133A	OVGP1 ERAP1 DTNA PLCH1 ZFX	1.34e-04	197	57	5	5090_DN
Drug	Articaine hydrochloride [23964-57-0]; Up 200; 12.4uM; MCF7; HT_HG-U133A	TAOK2 OVGP1 ERAP1 DTNA PMEL	1.37e-04	198	57	5	6517_UP
Drug	Enalapril maleate [76095-16-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	FOXO1 DYNC2H1 DTNA TOP3A ZFX	1.37e-04	198	57	5	7428_UP
Drug	Methoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; MCF7; HT_HG-U133A	DTNA GNPTAB PLCH1 SLC25A37 GSN	1.37e-04	198	57	5	2893_DN
Drug	Zoxazolamine [61-80-3]; Down 200; 23.8uM; PC3; HT_HG-U133A	FZD3 SLC25A37 ABTB2 TOP3A ZFX	1.37e-04	198	57	5	6290_DN
Drug	Cortisone [53-06-5]; Down 200; 11uM; MCF7; HT_HG-U133A	FOXO1 DTNA SLC25A37 ABTB2 TOP3A	1.37e-04	198	57	5	7416_DN
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Up 200; 12.2uM; PC3; HT_HG-U133A	TAOK2 FOXO1 ABCC2 PLCH1 KDM6B	1.37e-04	198	57	5	6635_UP
Drug	Nitrendipine [39562-70-4]; Up 200; 11uM; PC3; HT_HG-U133A	TAOK2 ABCC2 PLCH1 KDM6B TOP3A	1.37e-04	198	57	5	6304_UP
Drug	Imipenem [74431-23-5]; Up 200; 13.4uM; PC3; HT_HG-U133A	TAOK2 OVGP1 DTNA PLCH1 KDM6B	1.37e-04	198	57	5	7294_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	DYNC2H1 INTS1 KDM6B ABTB2 TOP3A	1.37e-04	198	57	5	1650_DN
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TUBG2 FZD3 DYNC2H1 PLCH1 TOP3A	1.40e-04	199	57	5	3403_DN
Drug	Nitrocaramiphen hydrochloride; Down 200; 10.8uM; HL60; HT_HG-U133A	FOXO1 ABCC2 KDM6B TOP3A ZFX	1.40e-04	199	57	5	3125_DN
Drug	Nefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; PC3; HT_HG-U133A	TAOK2 DTNA PKN2 ACE RYR1	1.40e-04	199	57	5	3730_UP
Drug	Mometasone furoate [83919-23-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	TAOK2 PLCH1 KDM6B SLC25A37 TOP3A	1.40e-04	199	57	5	5541_DN
Drug	Carbamazepine [298-46-4]; Up 200; 17uM; HL60; HT_HG-U133A	TAOK2 RAP1GAP ERAP1 DTNA TOP3A	1.40e-04	199	57	5	1847_UP
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A	TSHZ2 ERAP1 DTNA ABCC2 ACE	1.40e-04	199	57	5	3777_UP
Drug	Lorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; HL60; HT_HG-U133A	ERAP1 DYNC2H1 DTNA PKN2 GSN	1.40e-04	199	57	5	3079_DN
Drug	Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A	DTNA ABCC2 TOP3A GSN ZFX	1.44e-04	200	57	5	3425_UP
Drug	NSC674039	ABCC2 ACE NR1I3	1.83e-04	44	57	3	CID000001249
Disease	complex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)	TUBG2 TUBG1	3.17e-06	2	53	2	DOID:0090138 (implicated_via_orthology)
Disease	cholestasis (biomarker_via_orthology)	ABCC2 ACE NR1I3	9.51e-05	49	53	3	DOID:13580 (biomarker_via_orthology)
Disease	Kunitz-type protease inhibitor 2 measurement	CATSPERG RYR1	1.41e-04	10	53	2	EFO_0008200
Disease	end stage renal disease (implicated_via_orthology)	ABCC2 ACE	5.89e-04	20	53	2	DOID:783 (implicated_via_orthology)
Disease	nephrotic syndrome (implicated_via_orthology)	NPHS1 ACE	8.52e-04	24	53	2	DOID:1184 (implicated_via_orthology)
Disease	body fat percentage, coronary artery disease	DYNC2H1 MC4R	8.52e-04	24	53	2	EFO_0001645, EFO_0007800
Disease	Albuminuria	NPHS1 ACE	8.52e-04	24	53	2	C0001925
Disease	Depressive Symptoms	TXNRD2 ACE	1.00e-03	26	53	2	C0086132
Disease	primary biliary cholangitis (biomarker_via_orthology)	ABCC2 ACE	1.16e-03	28	53	2	DOID:12236 (biomarker_via_orthology)
Disease	Intellectual Disability	KMT2C PUF60 ACTL6A MED13L KDM6B	1.23e-03	447	53	5	C3714756
Disease	proteinuria (implicated_via_orthology)	NPHS1 ACE	1.33e-03	30	53	2	DOID:576 (implicated_via_orthology)
Disease	blood pressure, chronic obstructive pulmonary disease	EEFSEC PKN2	1.52e-03	32	53	2	EFO_0000341, EFO_0004325

Protein segments in the cluster

Peptide	Gene	Start	Entry
DQGISGHHLMETSMT	CATSPERG	836	Q6ZRH7
GHHLMETSMTVNVVG	CATSPERG	841	Q6ZRH7
HQGHGIQSMRISMDG	CFAP43	681	Q8NDM7
TMDQLSTVHHEMGHI	ACE	381	P12821
TMLGVSHVVTTSVGM	ACTL6A	321	O96019
MLIGHSMGGAIAVHT	PPME1	151	Q9Y570
SNRIHTSAHVMSMGL	ODF4	121	Q2M2E3
TLLGAHTRHMGTMFE	NR1I3	116	Q14994
ETVMDGLHGGHISMS	NPHS1	386	O60500
GGMMVIIHSDSHLHT	OR5B21	41	A6NL26
GHSVHSSSMVMRTLN	KMT2C	2636	Q8NEZ4
ASHLVSQDGGMITMH	MED13L	346	Q71F56
IMHSGMNATTIHFNL	GNPTAB	601	Q3T906
SGETATMHILVVHAM	INTS1	1156	Q8N201
QFGGSMSLHGNHMTL	KIAA1109	4651	Q2LD37
NMLSHVGHTILGMNT	KDM6B	1361	O15054
TGIVNHTHSRMGSIM	CARM1	541	Q86X55
HTHSRMGSIMSTGIV	CARM1	546	Q86X55
LGSSSIAHMVMGTTN	ERAP1	866	Q9NZ08
ISAMLGEMENVHGHI	ABCC2	681	Q92887
MVSEQDHSKGHSTQM	OSBPL6	406	Q9BZF3
IATMGGTTLMASAHS	MAGEA13P	316	A6NCF6
AVSLMSHQTLEHMEG	PDP2	161	Q9P2J9
TSLVGTVMNGLSHLH	DYNC2H1	2166	Q8NCM8
HTVSTMPHTSGMNRL	FOXO1	541	Q12778
HLLHTGMTGTNVMDT	GLYCTK	501	Q8IVS8
THTMTHLGISRGMGL	CRTC2	311	Q53ET0
LFLIGMHTTGSMEVS	BPI	386	P17213
GGMGSFHAMINSSVH	ELOVL1	161	Q9BW60
QLTVMHMPGHSRGSI	MBLAC2	161	Q68D91
MVNSTHRGMHTSLHL	MC4R	1	P32245
IHSGATTSTMRGDMV	DTNA	681	Q9Y4J8
LSNNPMTHITHGTSM	FZD3	641	Q9NPG1
MTHITHGTSMNRVIE	FZD3	646	Q9NPG1
TLHTSTAMAAQHGMD	GSN	426	P06396
GTEHRAIMVDSMLHT	RYR1	2571	P21817
GTTMAMSAGTLLTAH	FAM168B	151	A1KXE4
TEITGAMTMTSVGHQ	OVGP1	471	Q12889
TTRTIGVMTMVHGDN	EPRS1	1276	P07814
IQDHMVSGASMTTRG	POLR1A	631	O95602
EQEHMSISGSSARHM	PUF60	436	Q9UHX1
STHMTAGAMAGILEH	SLC25A37	46	Q9NYZ2
LHIHSQSMMGLGGDE	RAP1GAP	401	P47736
MMQEGEHTVTSHSSI	TAOK2	401	Q9UL54
SNSERDLGTHMMHLS	SPATA31D4	796	Q6ZUB0
DLGTHMMHLSGNDSG	SPATA31D4	801	Q6ZUB0
AGGDLMMHIHTDVFS	PKN2	741	Q16513
SIGTGRAMLGTHTME	PMEL	171	P40967
SMLEAHGMGSSLHED	ABTB2	636	Q8N961
SNSERDLGTHMMHLS	SPATA31D3	796	P0C874
DLGTHMMHLSGNDSG	SPATA31D3	801	P0C874
HITVGHETVMGRLMF	EEFSEC	336	P57772
HRVSGLMMANHTSIS	TUBG1	371	P23258
SERDLETHMMHLSGN	SPATA31D1	801	Q6ZQQ2
ETHMMHLSGNDSGVR	SPATA31D1	806	Q6ZQQ2
GSSHDTLQQLTTHMM	TSHZ2	386	Q9NRE2
DTLQELTAHMMVTGH	TSHZ3	396	Q63HK5
TAHMSVTGEQLGMSS	PLCH1	1046	Q4KWH8
MTSVSGHLLAHDFQM	TOP3A	86	Q13472
SSMVIEHMASHGTRF	TXNRD2	261	Q9NNW7
SMSMPEHVLTGDSIH	ZFX	126	P17010
EGLGAAHTTITMAVM	ZDHHC8	176	Q9ULC8
HRVSGLMMANHTSIS	TUBG2	371	Q9NRH3
ALMASLGHTSFMSHI	ZNF772	61	Q68DY9
DTLQQLTAHMMVTGH	TSHZ1	426	Q6ZSZ6
MTSGLMGHSQLTTID	TOX4	131	O94842