Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	AGO2 NCBP1 CYFIP2 CYFIP1	1.31e-06	14	123	4	GO:0000340
GeneOntologyMolecularFunction	gamma-aminobutyric acid:sodium:chloride symporter activity	SLC6A6 SLC6A11 SLC6A12	4.50e-06	6	123	3	GO:0005332
GeneOntologyMolecularFunction	RNA cap binding	AGO2 NCBP1 CYFIP2 CYFIP1	7.57e-06	21	123	4	GO:0000339
GeneOntologyMolecularFunction	gamma-aminobutyric acid transmembrane transporter activity	SLC6A6 SLC6A11 SLC6A12	1.86e-05	9	123	3	GO:0015185
GeneOntologyMolecularFunction	ATP-dependent activity	PMS1 VWA8 DDX42 ATP10B DDX51 KATNAL1 KATNA1 ATP13A2 ABCA7 HLTF ACSF3 ATP2A3 DYNC1H1 HELLS	2.58e-05	614	123	14	GO:0140657
GeneOntologyMolecularFunction	D-ribulose-phosphate 3-epimerase activity	RPEL1 RPE	3.76e-05	2	123	2	GO:0004750
GeneOntologyMolecularFunction	ATP hydrolysis activity	PMS1 VWA8 DDX42 ATP10B DDX51 KATNAL1 KATNA1 ATP13A2 ABCA7 ATP2A3 DYNC1H1	9.02e-05	441	123	11	GO:0016887
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 CLCN1 CLCN2	9.22e-05	171	123	7	GO:0015103
GeneOntologyMolecularFunction	monocarboxylate:sodium symporter activity	SLC6A6 SLC6A11 SLC6A12	9.83e-05	15	123	3	GO:0140161
GeneOntologyMolecularFunction	taurine:sodium symporter activity	SLC6A6 SLC6A11	1.12e-04	3	123	2	GO:0005369
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC4A1 SLC6A6 SLC6A11 SLC6A12 CLCN1 CLCN2	1.25e-04	125	123	6	GO:0015108
GeneOntologyMolecularFunction	sodium:chloride symporter activity	SLC6A6 SLC6A11 SLC6A12	1.46e-04	17	123	3	GO:0015378
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC25A4 SLCO2B1 ATP13A2 ABCA7 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 SLC18A3 ATP2A3	1.79e-04	477	123	11	GO:0022804
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC6A6 SLC6A11 SLC6A12	2.06e-04	19	123	3	GO:0015355
GeneOntologyMolecularFunction	monoatomic anion:sodium symporter activity	SLC6A6 SLC6A11 SLC6A12	2.06e-04	19	123	3	GO:0015373
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC4A1 SLC6A6 SLC6A11 SLC6A12 CLCN1 CLCN2	3.48e-04	151	123	6	GO:0008509
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC6A12	3.69e-04	23	123	3	GO:0015377
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A6 SLC6A11 SLC6A12	3.69e-04	23	123	3	GO:0005283
GeneOntologyMolecularFunction	taurine transmembrane transporter activity	SLC6A6 SLC6A11	3.72e-04	5	123	2	GO:0005368
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC25A4 SLCO2B1 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 SLC18A3	5.01e-04	296	123	8	GO:0015291
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC6A12	5.35e-04	26	123	3	GO:0015296
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A6 SLC6A11 SLC6A12	7.41e-04	29	123	3	GO:0005416
GeneOntologyMolecularFunction	dolichyl-phosphate-mannose-protein mannosyltransferase activity	TMEM260 TMTC1	1.03e-03	8	123	2	GO:0004169
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC25A4 ATP13A2 CHRNA4 SLC4A1 SLC6A6 SLC6A11 SLC6A12 PIEZO2 CLCN1 CLCN2 SLC18A3 TRPM1 ATP2A3	1.22e-03	793	123	13	GO:0015075
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP4Z1 CYP11B2 PTGS2 CYP4Z2P KDM4A COQ7	1.29e-03	194	123	6	GO:0016705
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A6 SLC6A11 SLC6A12	1.29e-03	35	123	3	GO:0005343
GeneOntologyMolecularFunction	microtubule severing ATPase activity	KATNAL1 KATNA1	1.32e-03	9	123	2	GO:0008568
GeneOntologyMolecularFunction	racemase and epimerase activity, acting on carbohydrates and derivatives	RPEL1 RPE	2.00e-03	11	123	2	GO:0016857
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN1 CLCN2	2.00e-03	11	123	2	GO:0005247
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	PMS1 VWA8 DDX42 ATP10B DDX51 KATNAL1 ARHGAP35 KATNA1 ATP13A2 ABCA7 HLTF ATP2A3 DYNC1H1	2.03e-03	840	123	13	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	PMS1 VWA8 DDX42 ATP10B DDX51 KATNAL1 ARHGAP35 KATNA1 ATP13A2 ABCA7 HLTF ATP2A3 DYNC1H1	2.03e-03	840	123	13	GO:0016818
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC25A4 SLCO2B1 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6	2.28e-03	293	123	7	GO:0008514
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLCO2B1 SLC6A6 SLC6A11 SLC6A12	2.33e-03	90	123	4	GO:0008028
GeneOntologyMolecularFunction	transporter activity	SLC25A4 SLCO2B1 ATP10B ATP13A2 ABCA7 CHRNA4 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 PIEZO2 CLCN1 CLCN2 SLC18A3 TRPM1 ATP2A3	2.36e-03	1289	123	17	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A4 SLCO2B1 ATP13A2 ABCA7 CHRNA4 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 PIEZO2 CLCN1 CLCN2 SLC18A3 TRPM1 ATP2A3	2.42e-03	1180	123	16	GO:0022857
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	ATP13A2 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC18A3 ATP2A3	2.65e-03	301	123	7	GO:0022853
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	PMS1 VWA8 DDX42 ATP10B DDX51 KATNAL1 ARHGAP35 KATNA1 ATP13A2 ABCA7 ATP2A3 DYNC1H1	3.01e-03	775	123	12	GO:0017111
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO2B1 SLC22A6	3.26e-03	14	123	2	GO:0015132
Domain	HMG_box	PMS1 SOX10 SOX30 SOX13 SOX14	2.65e-05	53	124	5	PF00505
Domain	HMG_BOX_2	PMS1 SOX10 SOX30 SOX13 SOX14	2.90e-05	54	124	5	PS50118
Domain	HMG	PMS1 SOX10 SOX30 SOX13 SOX14	2.90e-05	54	124	5	SM00398
Domain	-	PMS1 SOX10 SOX30 SOX13 SOX14	3.17e-05	55	124	5	1.10.30.10
Domain	Cytoplasmic_FMR1-int	CYFIP2 CYFIP1	4.37e-05	2	124	2	IPR008081
Domain	Ribul_P_3_epim	RPEL1 RPE	4.37e-05	2	124	2	PF00834
Domain	KATNA1	KATNAL1 KATNA1	4.37e-05	2	124	2	IPR028596
Domain	DUF1712	CCZ1B CCZ1	4.37e-05	2	124	2	PF08217
Domain	RIBUL_P_3_EPIMER_1	RPEL1 RPE	4.37e-05	2	124	2	PS01085
Domain	FragX_IP	CYFIP2 CYFIP1	4.37e-05	2	124	2	PF05994
Domain	Ribul_P_3_epim	RPEL1 RPE	4.37e-05	2	124	2	IPR026019
Domain	DUF1712_fun	CCZ1B CCZ1	4.37e-05	2	124	2	IPR013176
Domain	Ribul_P_3_epim-like	RPEL1 RPE	4.37e-05	2	124	2	IPR000056
Domain	HMG_box_dom	PMS1 SOX10 SOX30 SOX13 SOX14	7.15e-05	65	124	5	IPR009071
Domain	RibuloseP-bd_barrel	RPEL1 RPE	1.31e-04	3	124	2	IPR011060
Domain	NA_NEUROTRAN_SYMP_2	SLC6A6 SLC6A11 SLC6A12	2.17e-04	18	124	3	PS00754
Domain	SNF	SLC6A6 SLC6A11 SLC6A12	2.56e-04	19	124	3	PF00209
Domain	Na/ntran_symport	SLC6A6 SLC6A11 SLC6A12	2.56e-04	19	124	3	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A6 SLC6A11 SLC6A12	2.56e-04	19	124	3	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A6 SLC6A11 SLC6A12	2.56e-04	19	124	3	PS50267
Domain	DUF1394	CYFIP2 CYFIP1	2.60e-04	4	124	2	IPR009828
Domain	DUF1394	CYFIP2 CYFIP1	2.60e-04	4	124	2	PF07159
Domain	FerI	MYOF OTOF	4.32e-04	5	124	2	SM01202
Domain	FerB	MYOF OTOF	4.32e-04	5	124	2	SM01201
Domain	Ferlin_B-domain	MYOF OTOF	4.32e-04	5	124	2	IPR012561
Domain	Ferlin_C	MYOF OTOF	4.32e-04	5	124	2	PF16165
Domain	Ferlin_C	MYOF OTOF	4.32e-04	5	124	2	IPR032362
Domain	FerIin_dom	MYOF OTOF	4.32e-04	5	124	2	IPR012968
Domain	FerI	MYOF OTOF	4.32e-04	5	124	2	PF08151
Domain	FerB	MYOF OTOF	4.32e-04	5	124	2	PF08150
Domain	DUF4704	NBEA WDFY3	4.32e-04	5	124	2	IPR031570
Domain	DUF4704	NBEA WDFY3	4.32e-04	5	124	2	PF15787
Domain	PH_BEACH	NBEA WDFY3	6.45e-04	6	124	2	PF14844
Domain	Vps4_C	KATNAL1 KATNA1	1.19e-03	8	124	2	IPR015415
Domain	PH-BEACH_dom	NBEA WDFY3	1.19e-03	8	124	2	IPR023362
Domain	Vps4_C	KATNAL1 KATNA1	1.19e-03	8	124	2	PF09336
Domain	-	NBEA WDFY3	1.19e-03	8	124	2	2.30.29.40
Domain	PH_BEACH	NBEA WDFY3	1.19e-03	8	124	2	PS51783
Domain	-	ATP10B ATP13A2 ATP2A3	1.23e-03	32	124	3	3.40.1110.10
Domain	-	ATP10B ATP13A2 ATP2A3	1.23e-03	32	124	3	2.70.150.10
Domain	AAA	VWA8 KATNAL1 KATNA1	1.47e-03	34	124	3	PS00674
Domain	Cl-channel_core	CLCN1 CLCN2	1.53e-03	9	124	2	IPR014743
Domain	-	CLCN1 CLCN2	1.53e-03	9	124	2	1.10.3080.10
Domain	Voltage_CLC	CLCN1 CLCN2	1.53e-03	9	124	2	PF00654
Domain	BEACH	NBEA WDFY3	1.53e-03	9	124	2	PS50197
Domain	Cl-channel_volt-gated	CLCN1 CLCN2	1.53e-03	9	124	2	IPR001807
Domain	Beach	NBEA WDFY3	1.53e-03	9	124	2	PF02138
Domain	-	NBEA WDFY3	1.53e-03	9	124	2	1.10.1540.10
Domain	Beach	NBEA WDFY3	1.53e-03	9	124	2	SM01026
Domain	BEACH_dom	NBEA WDFY3	1.53e-03	9	124	2	IPR000409
Domain	ATPase_P-typ_cyto_domN	ATP10B ATP13A2 ATP2A3	1.60e-03	35	124	3	IPR023299
Domain	ATPase_P-typ_P_site	ATP10B ATP13A2 ATP2A3	1.74e-03	36	124	3	IPR018303
Domain	P_typ_ATPase	ATP10B ATP13A2 ATP2A3	1.74e-03	36	124	3	IPR001757
Domain	ATPASE_E1_E2	ATP10B ATP13A2 ATP2A3	1.74e-03	36	124	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP10B ATP13A2 ATP2A3	1.88e-03	37	124	3	IPR008250
Domain	E1-E2_ATPase	ATP10B ATP13A2 ATP2A3	1.88e-03	37	124	3	PF00122
Domain	HAT	XAB2 TMTC1	1.90e-03	10	124	2	SM00386
Domain	Hydrolase_3	ATP10B ATP2A3	1.90e-03	10	124	2	PF08282
Domain	HAT	XAB2 TMTC1	1.90e-03	10	124	2	IPR003107
Domain	AAA	VWA8 KATNAL1 KATNA1 ABCA7 DYNC1H1	2.75e-03	144	124	5	SM00382
Domain	AAA+_ATPase	VWA8 KATNAL1 KATNA1 ABCA7 DYNC1H1	2.75e-03	144	124	5	IPR003593
Domain	ATPase_dyneun-rel_AAA	VWA8 DYNC1H1	3.78e-03	14	124	2	IPR011704
Domain	AAA_5	VWA8 DYNC1H1	3.78e-03	14	124	2	PF07728
Domain	Helicase_C	DDX42 DDX51 HLTF HELLS	5.64e-03	107	124	4	PF00271
Domain	HELICc	DDX42 DDX51 HLTF HELLS	5.64e-03	107	124	4	SM00490
Domain	Helicase_C	DDX42 DDX51 HLTF HELLS	5.83e-03	108	124	4	IPR001650
Domain	HELICASE_CTER	DDX42 DDX51 HLTF HELLS	6.02e-03	109	124	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX42 DDX51 HLTF HELLS	6.02e-03	109	124	4	PS51192
Domain	DEXDc	DDX42 DDX51 HLTF HELLS	6.02e-03	109	124	4	SM00487
Domain	Helicase_ATP-bd	DDX42 DDX51 HLTF HELLS	6.22e-03	110	124	4	IPR014001
Domain	Cation_ATPase_N	ATP13A2 ATP2A3	6.24e-03	18	124	2	SM00831
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC25A4 SLCO2B1 ATP10B LCAT ATP13A2 ABCA7 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 CLCN1 CLCN2 TRPM1 ATP2A3	4.14e-05	681	94	15	MM14985
Pathway	REACTOME_CREATINE_METABOLISM	GAMT SLC6A11 SLC6A12	4.56e-05	11	94	3	M27681
Pathway	REACTOME_CREATINE_METABOLISM	GAMT SLC6A11 SLC6A12	4.56e-05	11	94	3	MM15402
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC25A4 SLCO2B1 ATP10B LCAT ATP13A2 ABCA7 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 CLCN1 CLCN2 TRPM1 ATP2A3	9.97e-05	736	94	15	M27287
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A6 SLC6A11 SLC6A12	2.57e-04	19	94	3	M27362
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A6 SLC6A11 SLC6A12	2.57e-04	19	94	3	MM15107
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 VWA8 MAPKAPK2 FBXL12 ARHGAP35 ATP13A2 CNTROB ABCA7 TBC1D9 MYOF RADIL SSH1 WDFY3 ATP2A3 DYNC1H1 AHNAK2	3.96e-06	1105	130	16	35748872
Pubmed	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	LCAT F2 TFAP2B PTGS2 CHRNA4 ADRB2	9.48e-06	129	130	6	19336370
Pubmed	Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.	AGO2 MAPKAPK2	1.39e-05	2	130	2	18476811
Pubmed	Ferlin Overview: From Membrane to Cancer Biology.	MYOF OTOF	1.39e-05	2	130	2	31443490
Pubmed	Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization.	PTGS2 ADRB2	1.39e-05	2	130	2	26098693
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP2 CYFIP1	1.39e-05	2	130	2	38128786
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z1 CYP4Z2P	1.39e-05	2	130	2	28236635
Pubmed	Nicotine impairs cyclooxygenase-2-dependent kinin-receptor-mediated murine airway relaxations.	PTGS2 BDKRB2	1.39e-05	2	130	2	24380835
Pubmed	Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.	ST8SIA1 SSH1	1.39e-05	2	130	2	31537151
Pubmed	Protein kinases as regulators of osmolyte accumulation under stress conditions: An overview.	SLC6A6 SLC6A12	1.39e-05	2	130	2	32114438
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z1 CYP4Z2P	1.39e-05	2	130	2	15059886
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP2 CYFIP1	1.39e-05	2	130	2	29752658
Pubmed	Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas.	PTGS2 BDKRB2	1.39e-05	2	130	2	19074839
Pubmed	JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure.	SFRP4 KDM4A	1.39e-05	2	130	2	38411359
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z1 CYP4Z2P	1.39e-05	2	130	2	25701119
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP2 CYFIP1	1.39e-05	2	130	2	24357318
Pubmed	KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons.	KATNAL1 KATNA1	1.39e-05	2	130	2	30448058
Pubmed	The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.	KATNAL1 KATNA1	1.39e-05	2	130	2	37882691
Pubmed	STAT6-IP-Dependent Disruption of IL-33-Mediated ILC2 Expansion and Type 2 Innate Immunity in the Murine Lung.	STAT6 IL33	1.39e-05	2	130	2	36426982
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP2 CYFIP1	1.39e-05	2	130	2	34327661
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP2 CYFIP1	1.39e-05	2	130	2	35567753
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP2 CYFIP1	1.39e-05	2	130	2	31324746
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX10 SOX13 SOX14	1.42e-05	13	130	3	8441686
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX10 SOX30 SOX13	2.25e-05	15	130	3	30871468
Pubmed	MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.	SOX10 CHRNA4 SLC18A3	3.34e-05	17	130	3	36897571
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX10 SOX13 SOX14	3.34e-05	17	130	3	27241892
Pubmed	Expression of Sox genes in tooth development.	SOX10 SOX13 SOX14	4.00e-05	18	130	3	26864488
Pubmed	Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.	PTGS2 ADRB2	4.15e-05	3	130	2	20395378
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	4.15e-05	3	130	2	32160108
Pubmed	The C2 domains of otoferlin, dysferlin, and myoferlin alter the packing of lipid bilayers.	MYOF OTOF	4.15e-05	3	130	2	23859474
Pubmed	Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.	SLC6A11 SLC6A12	4.15e-05	3	130	2	29175673
Pubmed	Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.	UGT1A9 SLC22A6	4.15e-05	3	130	2	19082692
Pubmed	The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.	STAT6 IL33	4.15e-05	3	130	2	23733876
Pubmed	β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility.	PTGS2 ADRB2	4.15e-05	3	130	2	31425733
Pubmed	FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins.	MYOF OTOF	4.15e-05	3	130	2	30026467
Pubmed	Association between candidate genes and lung function growth in Chinese asthmatic children.	STAT6 ADRB2	4.15e-05	3	130	2	17883727
Pubmed	Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors.	PTGS2 ADRB2	4.15e-05	3	130	2	19538012
Pubmed	Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population.	ADRB2 IL33	4.15e-05	3	130	2	31685439
Pubmed	Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells. Role of receptor changes, adenylyl cyclase, cyclo-oxygenase 2, and protein kinase A.	PTGS2 ADRB2	4.15e-05	3	130	2	15833737
Pubmed	Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.	CYP11B2 BDKRB2	4.15e-05	3	130	2	12107246
Pubmed	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	RPEL1 RPE	4.15e-05	3	130	2	7396409
Pubmed	PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin.	F2 PTGS2	4.15e-05	3	130	2	12505789
Pubmed	Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.	CYP4Z1 CYP4Z2P	4.15e-05	3	130	2	30832689
Pubmed	MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.	MAPKAPK2 PTGS2	4.15e-05	3	130	2	20339119
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	RNF121 PCGF1 AGO2 DDX42 ARHGAP35 CYFIP1 ALDH16A1 WDFY3 CNOT1	5.20e-05	450	130	9	16751776
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A6 SLC6A11 SLC6A12	6.46e-05	21	130	3	16125675
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX10 SOX30 SOX13	6.46e-05	21	130	3	12815626
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	AGO2 MED27 CNOT1 AHNAK2	7.23e-05	59	130	4	28813667
Pubmed	IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro.	MAPKAPK2 IL33	8.28e-05	4	130	2	31334837
Pubmed	IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.	MAPKAPK2 IL33	8.28e-05	4	130	2	33427298
Pubmed	Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.	KDM4A PINK1	8.28e-05	4	130	2	29413154
Pubmed	Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.	SLC6A6 SLC6A11	8.28e-05	4	130	2	30270321
Pubmed	IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6.	PTGS2 STAT6	8.28e-05	4	130	2	21277633
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP2 CYFIP1	8.28e-05	4	130	2	27605705
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP2 CYFIP1	8.28e-05	4	130	2	20228810
Pubmed	Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.	F2 SSH1	8.28e-05	4	130	2	24039253
Pubmed	Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.	ATP13A2 PINK1	8.28e-05	4	130	2	34827672
Pubmed	Structural imaging in the presymptomatic stage of genetically determined parkinsonism.	ATP13A2 PINK1	8.28e-05	4	130	2	20483373
Pubmed	IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.	STAT6 IL33	8.28e-05	4	130	2	24043894
Pubmed	AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.	MYOF AHNAK2	8.28e-05	4	130	2	17185750
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP2 CYFIP1	8.28e-05	4	130	2	15294869
Pubmed	Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism.	ATP13A2 PINK1	8.28e-05	4	130	2	18785233
Pubmed	Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.	SOX10 PTGS2	8.28e-05	4	130	2	26586201
Pubmed	Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.	PTGS2 BDKRB2	8.28e-05	4	130	2	17328065
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	8.28e-05	4	130	2	20305638
Pubmed	CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.	CYP11B2 ADRB2	8.28e-05	4	130	2	17003099
Pubmed	Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].	SLC6A11 SLC6A12	8.28e-05	4	130	2	8420981
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	AGO2 SLC25A4 VWA8 KATNA1 ABCA7 MRPL16 CCZ1 AHNAK2	9.28e-05	378	130	8	34315543
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VWA8 SSPOP XAB2 IGSF1 PDZD2	1.33e-04	130	130	5	12421765
Pubmed	Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges.	SLC6A11 SLC6A12	1.38e-04	5	130	2	8956109
Pubmed	IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.	BDKRB2 STAT6	1.38e-04	5	130	2	23351078
Pubmed	Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.	KATNA1 DYNC1H1	1.38e-04	5	130	2	16203747
Pubmed	Involvement of microRNA in AU-rich element-mediated mRNA instability.	AGO2 PTGS2	1.38e-04	5	130	2	15766526
Pubmed	IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.	STAT6 IL33	1.38e-04	5	130	2	18802081
Pubmed	Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.	KATNAL1 KATNA1	1.38e-04	5	130	2	26929214
Pubmed	Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.	SLC6A11 SLC6A12	1.38e-04	5	130	2	22896705
Pubmed	IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.	STAT6 IL33	1.38e-04	5	130	2	28374774
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	CYFIP2 CYFIP1	2.06e-04	6	130	2	11438699
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN1 CLCN2	2.06e-04	6	130	2	10198195
Pubmed	MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel.	MRGPRD PIEZO2	2.06e-04	6	130	2	36961815
Pubmed	Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.	KATNAL1 KATNA1	2.06e-04	6	130	2	28436967
Pubmed	Genetic influence on baroreflex sensitivity in normotensive young men.	CYP11B2 BDKRB2	2.06e-04	6	130	2	20300066
Pubmed	Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.	CYFIP2 CYFIP1	2.06e-04	6	130	2	31853374
Pubmed	The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells.	RPEL1 RPE	2.06e-04	6	130	2	5360673
Pubmed	Predominance of interaction among wild-type alleles of CYP11B2 in Himalayan natives associates with high-altitude adaptation.	CYP11B2 ADRB2	2.06e-04	6	130	2	16893516
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	F2 PTGS2 ADRB2	2.81e-04	34	130	3	19238444
Pubmed	The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.	MAPKAPK2 IL33	2.88e-04	7	130	2	32424229
Pubmed	Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.	CYFIP2 CYFIP1	2.88e-04	7	130	2	30687000
Pubmed	The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.	MAPKAPK2 IL33	2.88e-04	7	130	2	29288203
Pubmed	[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study].	CYP11B2 ADRB2	2.88e-04	7	130	2	16615274
Pubmed	SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.	HLTF AHNAK2	2.88e-04	7	130	2	23415230
Pubmed	IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.	STAT6 IL33	2.88e-04	7	130	2	23006545
Pubmed	Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies.	BDKRB2 DYNC1H1	2.88e-04	7	130	2	9887344
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SOX10 GAMT NCBP1 NBEA PREPL XAB2 STAT6 HEATR6 OTOF NEMF KDM4A WDFY3 DYNC1H1 PINK1	3.34e-04	1285	130	14	35914814
Pubmed	Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.	TFAP2B TRPM1 SYT13	3.61e-04	37	130	3	20510229
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	DDX42 XAB2 DYNC1H1 HELLS	3.71e-04	90	130	4	35654790
Pubmed	The transcription factor Sox5 modulates Sox10 function during melanocyte development.	SOX10 SOX13	3.83e-04	8	130	2	18703590
Pubmed	Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.	CLCN1 CLCN2	3.83e-04	8	130	2	27580824
Pubmed	Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).	SOX10 TFAP2B	3.83e-04	8	130	2	36867129
Pubmed	Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners.	BDKRB2 ADRB2	3.83e-04	8	130	2	20044476
Cytoband	7p22.1	CCZ1B RSPH10B2 RADIL CCZ1 RSPH10B	2.35e-07	47	130	5	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	CCZ1B RSPH10B2 RADIL CCZ1 RSPH10B	4.20e-05	134	130	5	chr7p22
GeneFamily	SRY-boxes	SOX10 SOX30 SOX13 SOX14	2.40e-06	19	93	4	757
GeneFamily	Ferlin family	MYOF OTOF	3.87e-04	6	93	2	828
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA WDFY3	9.20e-04	9	93	2	1230
GeneFamily	Solute carriers	SLC25A4 SLCO2B1 SLC4A1 SLC6A6 SLC6A11 SLC6A12 SLC22A6 SLC18A3	9.77e-04	395	93	8	752
GeneFamily	Chloride voltage-gated channels	CLCN1 CLCN2	1.15e-03	10	93	2	302
GeneFamily	Parkinson disease associated genes	ATP13A2 PINK1	3.00e-03	16	93	2	672
Coexpression	GSE6259_33D1_POS_DC_VS_CD8_TCELL_UP	DDX51 CNTROB SOX13 BDKRB2 PLCH2 SYT13 AHNAK2	6.34e-06	145	125	7	M6758
Coexpression	SMID_BREAST_CANCER_BASAL_DN	SFRP4 GAMT PGGHG AOX1 NBEA CRISP3 ARHGAP35 TFAP2B TBC1D9 PIEZO2 HEATR6 ATP2A3 IL33 COQ7	6.48e-06	699	125	14	M4960
Coexpression	DESCARTES_ORGANOGENESIS_SENSORY_NEURONS	VWA5B2 PCGF1 BDKRB2 TBC1D9 CYFIP2 SYT13	2.02e-05	116	125	6	MM3649
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEA CYFIP2 SLC6A6 ATP2A3 SYT13 DYNC1H1 PHLDB2	1.74e-06	195	130	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEA CYFIP2 SLC6A6 ATP2A3 SYT13 DYNC1H1 PHLDB2	1.74e-06	195	130	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP4 TBC1D9 MYOF ADRB2 ADGRL3 HELLS	5.69e-06	152	130	6	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	AOX1 JAML TFAP2B SLC6A12 SLC22A6 SSC5D	7.36e-06	159	130	6	92049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAML CYFIP2 SLC6A12 MYOF USH2A RASGRP2	9.10e-06	165	130	6	ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCell	lymphoid-B_cell-pro-B\|lymphoid / Lineage, cell class and subclass	SFRP4 GPR173 AOX1 F2 PIEZO2 CD79B	9.10e-06	165	130	6	8126c2f7810fc6e09b18783aadf6434ae12b0514
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 CHRNA4 SLC6A12 SLC22A6 PLCH2 PDZD2	1.36e-05	177	130	6	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP10B TFAP2B CYFIP2 PIEZO2 CD79B USH2A	1.40e-05	178	130	6	4289e435d465b7a1490d13bf05278f4ed77d69cd
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	NEXMIF NBEA PREPL TBC1D9 IGSF1 SYT13	1.45e-05	179	130	6	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 CHRNA4 SLC6A12 SLC22A6 PLCH2 PDZD2	1.64e-05	183	130	6	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFN1 SSPOP PIEZO2 OTOGL USH2A ADGRL3	1.69e-05	184	130	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFN1 SSPOP PIEZO2 OTOGL USH2A ADGRL3	1.69e-05	184	130	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFN1 SSPOP PIEZO2 OTOGL USH2A ADGRL3	1.69e-05	184	130	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLCO2B1 BDKRB2 TBC1D9 TMTC1 SSH1 ADGRL3	1.74e-05	185	130	6	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 MCF2 ST8SIA1 SSC5D TMTC1 PIEZO2	1.85e-05	187	130	6	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 MCF2 ST8SIA1 SSC5D TMTC1 PIEZO2	1.85e-05	187	130	6	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 MCF2 ST8SIA1 SSC5D TMTC1 PIEZO2	1.91e-05	188	130	6	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	control-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NBEA ST8SIA1 ATP13A2 PREPL ADRB2 HLTF	2.09e-05	191	130	6	afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn-Endothelial_Tip.Dcn.Nenf_(Nenf)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SFRP4 JAML SLC6A12 SLC22A6 SSC5D	2.13e-05	114	130	5	7be16e7f7b9c9dbd68933ace3b7f8f661bed41a7
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Dcn\|Thalamus / BrainAtlas - Mouse McCarroll V32	SFRP4 JAML SLC6A12 SLC22A6 SSC5D	2.13e-05	114	130	5	f4bdfc47418d22a49e0c4a6c3bd0663e15fb53bb
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCLY PREPL CYFIP2 USH2A ATP2A3 SYT13	2.15e-05	192	130	6	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KLHL1 BDKRB2 TMTC1 SSH1 IL33 ADGRL3	2.15e-05	192	130	6	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A2 SOX13 PIEZO2 ATP2A3 ADGRL3 PHLDB2	2.28e-05	194	130	6	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GAMT SLC6A6 GCLC PLCH2 IL33 AHNAK2	2.55e-05	198	130	6	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	MOGAT2 MCF2 CNTROB OTOF IGSF1	3.31e-05	125	130	5	6cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCell	PND01-03-samps-Lymphocyte-B_cell-B_cell_1\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SSPOP CYFIP2 CLCN2 CD79B HELLS	3.71e-05	128	130	5	5d82247ceda55017628720ed8b6c36ff7cec8437
ToppCell	PND01-03-samps-Lymphocyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SSPOP CYFIP2 CLCN2 CD79B HELLS	3.71e-05	128	130	5	d3158825a2178244b57ac5ad2676617fd58d8466
ToppCell	PND01-03-samps-Lymphocyte-B_cell\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SSPOP CYFIP2 CLCN2 CD79B HELLS	3.71e-05	128	130	5	7661402dd7cd533c1bfe8d9247cecd88c1be9a5e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPR173 SSC5D HLTF USH2A SYT13	4.15e-05	131	130	5	1823cab28fab40486247ca92104267b1e370bdc1
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	JAML TBC1D9 MYOF TMTC1 ADGRL3	5.13e-05	137	130	5	12caa8ed7cc9e7a0f78c14ad5efe2fc28c3ce9be
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)\|Striatum / BrainAtlas - Mouse McCarroll V32	BDKRB2 SLC18A3 HSD17B13 SOX14	7.27e-05	76	130	4	3073a8ace46ad18bddd22ec8f3a1b59ee2fd989d
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)-\|Striatum / BrainAtlas - Mouse McCarroll V32	BDKRB2 SLC18A3 HSD17B13 SOX14	7.27e-05	76	130	4	3f5865b9cb6648b88eb873018e513c5efb457ae5
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat\|Striatum / BrainAtlas - Mouse McCarroll V32	BDKRB2 SLC18A3 HSD17B13 SOX14	7.27e-05	76	130	4	041a8984b3ae4bb03ae6db8234c1333ac73098fa
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	JAML TFAP2B SLC6A12 SLC22A6 SSC5D	8.66e-05	153	130	5	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	JAML TFAP2B SLC6A12 SLC22A6 SSC5D	8.66e-05	153	130	5	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	JAML TFAP2B SLC6A12 SLC22A6 SSC5D	8.66e-05	153	130	5	2513edfae62a44e51d3556675a096723194c966c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOX1 SLC6A11 SSC5D OTOGL SPEM1	8.93e-05	154	130	5	5ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SFRP4 KATNAL1 BDKRB2 RADIL AHNAK2	8.93e-05	154	130	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	AOX1 JAML TFAP2B SLC6A12 SLC22A6	8.93e-05	154	130	5	65dbb60f636562eeba3dafadae9c0c7db2b27476
Drug	Chlorides	SLC4A1 SLC6A11 SLC22A6 ADRB2 CLCN1 CLCN2	1.19e-07	42	127	6	ctd:D002712
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP2 CYFIP1	4.99e-05	3	121	2	DOID:0060393 (implicated_via_orthology)
Disease	revision of total knee arthroplasty	SLC6A6 MED27 ADGRL3	1.63e-04	26	121	3	EFO_0020972
Disease	dilated cardiomyopathy 1H (is_implicated_in)	SLC25A4 CYP11B2	1.65e-04	5	121	2	DOID:0110429 (is_implicated_in)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B2 CLCN2	1.65e-04	5	121	2	DOID:446 (is_implicated_in)
Disease	cystic fibrosis (is_implicated_in)	PTGS2 ADRB2 GCLC	1.83e-04	27	121	3	DOID:1485 (is_implicated_in)
Disease	Conn Syndrome	CYP11B2 CLCN2	2.47e-04	6	121	2	C1384514
Disease	Hyperaldosteronism	CYP11B2 CLCN2	2.47e-04	6	121	2	C0020428
Disease	10-undecenoate 11:1n1 measurement	CYP4Z1 CYP4Z2P	3.46e-04	7	121	2	EFO_0021099
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	MYOF OTOF	3.46e-04	7	121	2	DOID:11724 (implicated_via_orthology)
Disease	Dystonia	GAMT ATP13A2 CHRNA4 PINK1	4.41e-04	86	121	4	C0013421
Disease	heart disease (implicated_via_orthology)	SOX13 ATP2A3 CNOT1	5.11e-04	38	121	3	DOID:114 (implicated_via_orthology)
Disease	Autistic Disorder	DOCK4 VWA8 NBEA PTGS2 CHRNA4 ADRB2	7.44e-04	261	121	6	C0004352
Disease	myocardial infarction (is_implicated_in)	F2 PTGS2 ADRB2 GCLC	7.50e-04	99	121	4	DOID:5844 (is_implicated_in)
Disease	Thrombus	F2 PTGS2 BDKRB2	8.98e-04	46	121	3	C0087086
Disease	Seizures, Focal	GAMT PTGS2 CHRNA4 DYNC1H1	9.02e-04	104	121	4	C0751495
Disease	Schizophrenia	DOCK4 SOX10 F2 PTGS2 CHRNA4 SLC6A11 SLC6A12 CYFIP1 GCLC TRPM1 PINK1	1.04e-03	883	121	11	C0036341
Disease	Hirschsprung's disease (implicated_via_orthology)	SOX10 PINK1	1.07e-03	12	121	2	DOID:10487 (implicated_via_orthology)
Disease	Thrombosis	F2 PTGS2 BDKRB2	1.08e-03	49	121	3	C0040053
Disease	Reactive Hyperemia	PTGS2 BDKRB2	1.26e-03	13	121	2	C0178824
Disease	Anemia, Hemolytic, Acquired	SLC4A1 GCLC	1.26e-03	13	121	2	C0002879
Disease	Anemia, Hemolytic	SLC4A1 GCLC	1.26e-03	13	121	2	C0002878
Disease	Amino Acid Metabolism, Inherited Disorders	GAMT GCLC	1.26e-03	13	121	2	C0750905
Disease	Anemia, Microangiopathic	SLC4A1 GCLC	1.26e-03	13	121	2	C0002889
Disease	pleurisy (implicated_via_orthology)	PTGS2 BDKRB2	1.26e-03	13	121	2	DOID:10247 (implicated_via_orthology)
Disease	Venous Engorgement	PTGS2 BDKRB2	1.26e-03	13	121	2	C0042484
Disease	Microangiopathic hemolytic anemia	SLC4A1 GCLC	1.26e-03	13	121	2	C0221021
Disease	Amino Acid Metabolism, Inborn Errors	GAMT GCLC	1.26e-03	13	121	2	C0002514
Disease	pulmonary emphysema (implicated_via_orthology)	PTGS2 GCLC	1.26e-03	13	121	2	DOID:9675 (implicated_via_orthology)
Disease	Active Hyperemia	PTGS2 BDKRB2	1.26e-03	13	121	2	C0333233
Disease	Hyperemia	PTGS2 BDKRB2	1.26e-03	13	121	2	C0020452
Disease	nervous system disorder	PTGS2 CHRNA4 ADRB2	1.36e-03	53	121	3	C0027765
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.47e-03	14	121	2	DOID:3753 (implicated_via_orthology)
Disease	Alzheimer's disease (implicated_via_orthology)	SOX13 PTGS2 IL33	1.67e-03	57	121	3	DOID:10652 (implicated_via_orthology)
Disease	CCL2 measurement	ABCA7 SLC4A1 RADIL KDM4A	1.83e-03	126	121	4	EFO_0004749
Disease	asthma (biomarker_via_orthology)	PTGS2 STAT6 SLC18A3	1.85e-03	59	121	3	DOID:2841 (biomarker_via_orthology)
Disease	Myasthenic Syndromes, Congenital, Slow Channel	PREPL SLC18A3	1.93e-03	16	121	2	C0751885
Disease	revision of total joint arthroplasty, aseptic loosening	SLC6A6 MED27	1.93e-03	16	121	2	EFO_0010725, EFO_0020974
Disease	Congenital Myasthenic Syndromes, Postsynaptic	PREPL SLC18A3	2.18e-03	17	121	2	C0751883
Disease	S-adenosylhomocysteine measurement	VWA8 KATNA1	2.18e-03	17	121	2	EFO_0010531
Disease	non-Hodgkin lymphoma (is_implicated_in)	TMEM260 CD79B	2.18e-03	17	121	2	DOID:0060060 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	PTGS2 BDKRB2 ADRB2	2.23e-03	63	121	3	DOID:3083 (is_implicated_in)
Disease	cholangiocarcinoma (is_marker_for)	UGT1A9 PTGS2 ADRB2	2.34e-03	64	121	3	DOID:4947 (is_marker_for)
Disease	stem Cell Factor measurement	LCAT ADRB2 AHNAK2	2.66e-03	67	121	3	EFO_0008291
Disease	Congenital Myasthenic Syndromes, Presynaptic	PREPL SLC18A3	2.72e-03	19	121	2	C0751884
Disease	portal hypertension (implicated_via_orthology)	PTGS2 BDKRB2	2.72e-03	19	121	2	DOID:10762 (implicated_via_orthology)
Disease	Cardiomyopathies, Primary	PTGS2 BDKRB2 ADRB2	2.89e-03	69	121	3	C0033141
Disease	Myocardial Diseases, Secondary	PTGS2 BDKRB2 ADRB2	2.89e-03	69	121	3	C0036529
Disease	Alzheimer disease, age at onset	ZNF862 TBC1D9 OTOF OTOGL TRPM1 USH2A	2.97e-03	343	121	6	EFO_0004847, MONDO_0004975
Disease	Hemorrhage	F2 BDKRB2	3.02e-03	20	121	2	C0019080
Disease	end stage renal disease (implicated_via_orthology)	LCAT F2	3.02e-03	20	121	2	DOID:783 (implicated_via_orthology)
Disease	Arthrogryposis	SLC18A3 DYNC1H1	3.33e-03	21	121	2	C0003886
Disease	Attention Deficit Disorder	CHRNA4 ADGRL3	3.65e-03	22	121	2	C0041671
Disease	Minimal Brain Dysfunction	CHRNA4 ADGRL3	3.65e-03	22	121	2	C1321905
Disease	Parkinson disease	ATP13A2 PINK1	3.65e-03	22	121	2	cv:C0030567

Protein segments in the cluster

Peptide	Gene	Start	Entry
KINPVWNEMIMFELP	SYT13	351	Q7L8C5
WQDVKSMMLVPEPTR	C2orf16	21	Q68DN1
MEPSWLQELMAHPFL	CYP4Z2P	1	Q8N1L4
LIESMHKMASAPRFW	CHRNA4	371	P43681
MFSPWKISMFLSVRE	BDKRB2	1	P30411
VVPFGAAHILMKMWT	ADRB2	86	P07550
LILPPTFSFLEMMWR	ALDH16A1	171	Q8IZ83
HPLGLRSEFPIWMMF	SLC4A1	651	P02730
RSEFPIWMMFASALP	SLC4A1	656	P02730
PTMEAWTLRKPFHMK	CTSL3P	126	Q5NE16
MWPSQLLIFMMLLAP	ADGRL3	1	Q9HAR2
MMPEFSPQQVWEKFL	ACSF3	266	Q4G176
LGHFWITKALLPSMM	HSD17B13	146	Q7Z5P4
MARLALSPVPSHWMV	CD79B	1	P40259
PWLLVAVAMSMALHF	ATP2A3	931	Q93084
LVILNWMPSMEVFHR	ATP10B	101	O94823
WMPSMEVFHREITML	ATP10B	106	O94823
EVWEMLGPRIFTFMN	ABCA7	326	Q8IZY2
GFHQSVRPSLWKMML	AGO2	201	Q9UKV8
MHSPPRDQAAIMLWK	TFAP2B	1	Q92481
FGSERMMWFSPVTLK	AOX1	236	Q06278
MADLVPDLQPILFWM	RADIL	496	Q96JH8
PHEPTMKMRHFLWML	RSPH10B	571	P0C881
PHEPTMKMRHFLWML	RSPH10B2	571	B2RC85
IQFPIEMSMPWILTD	CYFIP1	636	Q7L576
WMAEFKRFTPDIPTM	HELLS	286	Q9NRZ9
MRHFEALKLMVQAWP	PRAMEF17	46	Q5VTA0
TQRMTITEFMNHPWI	MAPKAPK2	311	P49137
VLRVMFEVWRNHPQM	NCBP1	586	Q09161
IRIHTTEFEWPKNMM	NEMF	56	O60524
TEFEWPKNMMPSSFA	NEMF	61	O60524
RDPQLVRMFLMMHPW	RASGRP2	31	Q7LDG7
VRMFLMMHPWYIPSS	RASGRP2	36	Q7LDG7
AFIWPMLIHIMDQKE	DDX42	306	Q86XP3
APAFPLAIKMMWNIS	PINK1	211	Q9BXM7
LFRQSKHPMANITWM	OR2T4	21	Q8NH00
RFWEHLSPVVHMVMA	OR51H1	266	Q8NH63
DMWLASFATPKMIRD	OR4K14	71	Q8NGD5
PVPEQGMWSRFHMAV	PDZD2	1991	O15018
LMHFDAWNIMKSVPE	PDZD2	2811	O15018
MTVARWMREFIANHP	GCLC	571	P48506
DQRAPVFLVVMFWTM	HEATR6	756	Q6AI08
SMVIWLLGFRMHRNP	MRGPRD	46	Q8TDS7
VMMQPDDWPFVVFIT	KDM4A	866	O75164
VPGLMMYATIWLREH	PTGS2	281	P35354
DQDLWMFPSILMFHP	PGGHG	301	Q32M88
PQMPDVVVRSFMTWL	MED27	256	Q6P2C8
QFPIEMSMPWILTDH	CYFIP2	661	Q96F07
IMATVWIERRLHTPM	OR10H3	46	O60404
IMAVIRFSWTLHTPM	OR10T2	46	Q8NGX3
RPVMHWPNVIMIMTD	KICS2	356	Q96MD2
MVEFAPLFMPWERRL	MOGAT2	1	Q3SYC2
RPHLMMLTLWFRAPF	MOGAT2	136	Q3SYC2
HVVVWMMAGIPLLLF	ATP13A2	51	Q9NQ11
MLMVTLSPTKDFWLH	IL33	181	O95760
LSMPLMIWVTDTFPK	IGSF1	956	Q8N6C5
PEMFPKDWTVMRLVA	DOCK4	961	Q8N1I0
IPIFHDMMDWEQRRS	DOCK4	1086	Q8N1I0
RAVSPPARNMLKMEW	CRISP3	51	P54108
MIDSMHQSWLPRVVA	DDX51	376	Q8N8A6
MVTFRVRPTVLMPLW	COQ7	101	Q99807
PEENFWMVMVVRNPI	CCZ1	96	P86791
PEENFWMVMVVRNPI	CCZ1B	96	P86790
MAWTLSVAMAFPPVF	GPR173	146	Q9NS66
WFSQEDFMLKLPVVM	MCF2	46	P10911
VMERWETPYMHALAA	GAMT	41	Q14353
MFAWKMVVLSLPRIQ	DYNC1H1	986	Q14204
KMVMVLAATNFPWDI	KATNA1	351	O75449
MFPSRMAWPEDHVFI	LCAT	276	P04180
SFEAMPMPEVTWLKD	IGFN1	971	Q86VF2
QLMFMPRSLSRWISP	CYP11B2	236	P19099
AFTMPLHMTFWGKEE	HLTF	141	Q14527
CMTLNVEWMPIHTRA	SLC22A6	206	Q4U2R8
RFPDAWLMTSKTEVM	PMS1	731	P54277
ERRVWTMPPMAVALK	CNTROB	596	Q8N137
AKPTVPMFTVWEMIT	OTOGL	1441	Q3ZCN5
EPQHSIPDIFIWMMS	OTOF	841	Q9HC10
VLPDHMTMKQIWLSR	PCGF1	226	Q9BSM1
GSPPFWHRKQMLMLR	PHKG1	226	Q16816
RSMDPKNMFAIWRVP	MRPL16	111	Q9NX20
PLKMITWTMPTAVFF	TAS2R60	196	P59551
REAVVLPMWMPDFFK	KATNAL1	221	Q9BW62
SRMMLVTWQHPRKSN	USH2A	2546	O75445
RAFVFMHKMPRLWLD	XAB2	101	Q9HCS7
AFLEPTIATWMKHTM	SLC18A3	306	Q16572
EMGMAWLPAFVPHVL	SLC18A3	326	Q16572
KAVTMMPLPTFWSIL	SLC6A6	376	P31641
WAASTVPFMMPTMAL	SSPOP	2441	A2VEC9
EVPFMHWRKNMLAFL	NBPF11	806	Q86T75
YMTMHPVWPSLRSDR	JAML	361	Q86YT9
QRFMMASIEPLWEPM	NEXMIF	1331	Q5QGS0
HVDLTLYTMRPKVMW	FBXL12	46	Q9NXK8
TTMFRIPEFKWSPMH	NBEA	1326	Q8NFP9
AFPKAVTMMPLSQLW	SLC6A12	366	P48065
MVWFLDFPNSMAPKR	SETSIP	1	P0DME0
MAVLAWKFPRTRLPM	ST8SIA1	16	Q92185
AVKRLAEMAWTTSMP	SSC5D	1541	A1L4H1
MVAPSPEAMRIWMDV	PHLDB2	1226	Q86SQ0
WPTLMRPDFSTMDAL	ARHGAP35	1401	Q9NRY4
MAMVERPRPEWASYH	SPEM1	1	Q8N4L4
HVKRPMNAFMVWARI	SOX30	336	O94993
MNAFMVWARIHRPAL	SOX30	341	O94993
RMHIFKPVSVQAMWS	SSH1	166	Q8WYL5
QESWFKMPKFRMPSL	AHNAK2	5186	Q8IVF2
MLPDPKNVHIFVSWM	SLC25A4	201	P12235
MKFWMSIVATTMPIP	CLCN1	466	P35523
MKFWMSALATTIPVP	CLCN2	441	P51788
SPSIRQLIMHAMAEW	CNOT1	531	A5YKK6
MEPSWLQELMAHPFL	CYP4Z1	1	Q86W10
SLEMPMWHPYKVDVT	TP53TG5	246	Q9Y2B4
DIIMHPKYWGRAFIM	PRSS45P	66	Q7RTY3
PLEPEVIQAMTKAMW	SCLY	41	Q96I15
SSHIKRPMNAFMVWA	SOX13	421	Q9UN79
WNMKRHEMVEEPPVI	ZNF676	31	Q8N7Q3
ARMTTWHIMIPSDIE	WDFY3	2166	Q8IZQ1
FPVSPRAVWSMMRFL	TMTC1	301	Q8IUR5
MMPKVHWLRTQFPSL	RPEL1	156	Q2QD12
IQFMFLRILAWMPSP	SLCO2B1	601	O94956
TWEETLVFMVHMPEI	PLCH2	816	O75038
MEQFRHLPMPFHWKQ	STAT6	111	P42226
AVRIPMCRHMPWNIT	SFRP4	26	Q6FHJ7
WTPFNKMHILGQMFV	TBC1D9	316	Q6ZT07
KPHVKRPMNAFMVWA	SOX10	101	P56693
SVPRPSRRFWMMAIV	PIEZO2	1956	Q9H5I5
VTMMPLSPLWATLFF	SLC6A11	386	P48066
FFVDEHSAVWVPMMK	SERPINA13P	211	Q6UXR4
TPAIMNWDLFFTMKR	PREPL	331	Q4J6C6
LKRMFSNPWERPHVM	RNF121	281	Q9H920
ARRMKPTHTMVNCWF	TMEM201	36	Q5SNT2
VPMDGSHWFTMRSVV	UGT1A9	31	O60656
PPQLKNMEVFDTMAW	ZNF862	941	O60290
PFHELMVWAVLMKRQ	TRPM1	611	Q7Z4N2
MDWDMLMEPPFLFTA	VWA5B2	806	Q8N398
EIGMSPWQVMLFRKS	F2	371	P00734
MMPKVHWLRTQFPSL	RPE	156	Q96AT9
DSFPMMPIKHAIQWL	VWA8	326	A3KMH1
DHIKRPMNAFMVWSR	SOX14	6	O95416
AAPKIRDNFWSMPMS	THEG	236	Q9P2T0
KPLFMGVVERFWMQS	TMEM260	346	Q9NX78
KTDTWTMVAPLSMPR	KLHL1	676	Q9NR64
EMDITPKLLWHPVMN	MYOF	1241	Q9NZM1