Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	EZH2 EHMT2	5.86e-06	6	13	2	GO:0046976
GeneOntologyMolecularFunction	channel activity	CALHM3 SCN11A SLC26A8 AQP12A AQP12B	1.33e-05	525	13	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CALHM3 SCN11A SLC26A8 AQP12A AQP12B	1.34e-05	526	13	5	GO:0022803
GeneOntologyMolecularFunction	water channel activity	AQP12A AQP12B	5.29e-05	17	13	2	GO:0015250
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP12A AQP12B	7.39e-05	20	13	2	GO:0005372
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CALHM3 SCN11A SLC26A8 AQP12A AQP12B	7.76e-05	758	13	5	GO:0015318
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	EZH2 EHMT2	3.64e-04	44	13	2	GO:0140938
GeneOntologyMolecularFunction	histone modifying activity	EZH2 EHMT2 MCM3AP	3.91e-04	229	13	3	GO:0140993
GeneOntologyMolecularFunction	transmembrane transporter activity	CALHM3 SCN11A SLC26A8 AQP12A AQP12B	6.17e-04	1180	13	5	GO:0022857
GeneOntologyMolecularFunction	transcription corepressor binding	EZH2 EHMT2	6.56e-04	59	13	2	GO:0001222
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	EZH2 EHMT2	8.70e-04	68	13	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	EZH2 EHMT2	8.96e-04	69	13	2	GO:0016278
GeneOntologyMolecularFunction	transporter activity	CALHM3 SCN11A SLC26A8 AQP12A AQP12B	9.24e-04	1289	13	5	GO:0005215
GeneOntologyMolecularFunction	histone methyltransferase activity	EZH2 EHMT2	9.48e-04	71	13	2	GO:0042054
GeneOntologyMolecularFunction	promoter-specific chromatin binding	EZH2 EHMT2	1.29e-03	83	13	2	GO:1990841
GeneOntologyMolecularFunction	protein methyltransferase activity	EZH2 EHMT2	1.98e-03	103	13	2	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	EZH2 EHMT2	2.06e-03	105	13	2	GO:0008170
GeneOntologyMolecularFunction	monoatomic ion channel activity	CALHM3 SCN11A SLC26A8	2.91e-03	459	13	3	GO:0005216
GeneOntologyMolecularFunction	transcription coregulator binding	EZH2 EHMT2	3.62e-03	140	13	2	GO:0001221
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	EZH2 EHMT2	5.41e-03	172	13	2	GO:0008757
GeneOntologyMolecularFunction	methyltransferase activity	EZH2 EHMT2	8.18e-03	213	13	2	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	EZH2 EHMT2	9.01e-03	224	13	2	GO:0016741
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	MCM3AP ZDHHC22	1.01e-02	238	13	2	GO:0016747
GeneOntologyMolecularFunction	chromatin binding	EZH2 EHMT2 MCM3AP	1.09e-02	739	13	3	GO:0003682
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CALHM3 SCN11A SLC26A8	1.32e-02	793	13	3	GO:0015075
GeneOntologyBiologicalProcess	water transport	AQP12A AQP12B	1.80e-04	32	13	2	GO:0006833
GeneOntologyBiologicalProcess	fluid transport	AQP12A AQP12B	3.11e-04	42	13	2	GO:0042044
GeneOntologyBiologicalProcess	DNA methylation-dependent constitutive heterochromatin formation	EZH2 EHMT2	3.42e-04	44	13	2	GO:0006346
GeneOntologyBiologicalProcess	response to antibiotic	EZH2 EHMT2	3.42e-04	44	13	2	GO:0046677
MousePheno	increased susceptibility to induced pancreatitis	AQP12A AQP12B	7.05e-05	15	12	2	MP:0004761
MousePheno	abnormal pancreatic acinar cell zymogen granule morphology	AQP12A AQP12B	9.12e-05	17	12	2	MP:0009160
MousePheno	abnormal pancreatic acinar cell morphology	AQP12A AQP12B	5.44e-04	41	12	2	MP:0009146
MousePheno	abnormal pancreatic acinus morphology	AQP12A AQP12B	5.98e-04	43	12	2	MP:0009145
Domain	Aquaporin_12	AQP12A AQP12B	4.47e-07	2	13	2	IPR023265
Domain	Aquaporin_11/12	AQP12A AQP12B	1.34e-06	3	13	2	IPR016697
Domain	MIP	AQP12A AQP12B	4.05e-05	14	13	2	PF00230
Domain	MIP	AQP12A AQP12B	4.05e-05	14	13	2	PS00221
Domain	-	AQP12A AQP12B	4.67e-05	15	13	2	1.20.1080.10
Domain	Aquaporin-like	AQP12A AQP12B	4.67e-05	15	13	2	IPR023271
Domain	MIP	AQP12A AQP12B	4.67e-05	15	13	2	IPR000425
Domain	SET	EZH2 EHMT2	3.61e-04	41	13	2	PF00856
Domain	SET	EZH2 EHMT2	4.55e-04	46	13	2	SM00317
Domain	SET_dom	EZH2 EHMT2	5.38e-04	50	13	2	IPR001214
Domain	SET	EZH2 EHMT2	5.38e-04	50	13	2	PS50280
Pathway	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	AQP12A AQP12B	2.82e-05	13	9	2	MM15095
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	EZH2 EHMT2	1.08e-04	25	9	2	MM15546
Pathway	KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES	EZH2 EHMT2	1.26e-04	27	9	2	M47941
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	EZH2 EHMT2	2.01e-04	34	9	2	M27826
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	AQP12A AQP12B	2.79e-04	40	9	2	MM15115
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	EZH2 EHMT2	3.70e-04	46	9	2	MM14933
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	EZH2 EHMT2 ZNF281	7.36e-04	301	9	3	MM15983
Pathway	WP_HISTONE_MODIFICATIONS	EZH2 EHMT2	7.38e-04	65	9	2	M39374
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	EZH2 EHMT2	8.56e-04	70	9	2	M27231
Pathway	REACTOME_CELLULAR_SENESCENCE	EZH2 EHMT2	2.45e-03	119	9	2	MM14901
Pathway	WP_ENDODERM_DIFFERENTIATION	EZH2 ZNF281	3.51e-03	143	9	2	M39591
Pathway	WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME	AQP12A AQP12B	3.61e-03	145	9	2	M45512
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	EZH2 EHMT2	5.21e-03	175	9	2	MM14941
Pathway	REACTOME_CELLULAR_SENESCENCE	EZH2 EHMT2	6.56e-03	197	9	2	M27188
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	EZH2 EHMT2	1.07e-02	254	9	2	M27131
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	EZH2 EHMT2	1.22e-02	272	9	2	M29619
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	1.29e-07	2	13	2	36167651
Pubmed	Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.	EZH2 EHMT2	1.29e-07	2	13	2	28246360
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	1.29e-07	2	13	2	15809071
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	1.29e-07	2	13	2	19726746
Pubmed	Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.	EZH2 EHMT2	3.87e-07	3	13	2	20005824
Pubmed	The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing.	EZH2 EHMT2	3.87e-07	3	13	2	24389103
Pubmed	A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.	EZH2 EHMT2	3.87e-07	3	13	2	24652950
Pubmed	Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis.	EZH2 EHMT2	3.87e-07	3	13	2	29053336
Pubmed	CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.	EZH2 EHMT2	7.74e-07	4	13	2	28486105
Pubmed	Dynamic patterns of histone lysine methylation in the developing retina.	EZH2 EHMT2	1.29e-06	5	13	2	20671280
Pubmed	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.	EZH2 EHMT2	1.29e-06	5	13	2	33311485
Pubmed	Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.	EZH2 EHMT2	3.61e-06	8	13	2	29146735
Pubmed	ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.	EZH2 EHMT2	5.79e-06	10	13	2	20569692
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	EZH2 EHMT2	7.08e-06	11	13	2	19144645
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP12A AQP12B	1.35e-05	15	13	2	34540996
Pubmed	Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage.	EZH2 EHMT2	1.35e-05	15	13	2	38167468
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP12A AQP12B	1.75e-05	17	13	2	26847765
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	EZH2 EHMT2	1.97e-05	18	13	2	29628311
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	EZH2 EHMT2 ZNF281	2.01e-05	146	13	3	23892456
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP12A AQP12B	2.20e-05	19	13	2	19367412
Pubmed	A critical function of Mad2l2 in primordial germ cell development of mice.	EZH2 EHMT2	2.20e-05	19	13	2	24009519
Pubmed	Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.	EZH2 EHMT2	9.98e-05	40	13	2	21151833
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	EZH2 EHMT2	1.32e-04	46	13	2	30419336
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	EZH2 EHMT2	1.50e-04	49	13	2	34368113
Pubmed	New nomenclature for chromatin-modifying enzymes.	EZH2 EHMT2	2.03e-04	57	13	2	18022353
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	EZH2 ZNF281 MCM3AP	2.48e-04	341	13	3	32971831
Pubmed	Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.	EZH2 EHMT2	2.49e-04	63	13	2	25680957
Pubmed	Interaction network of human early embryonic transcription factors.	EHMT2 ZNF281 MCM3AP	2.70e-04	351	13	3	38297188
Interaction	TMEM88 interactions	MICAL1 ZDHHC22	3.67e-05	17	11	2	int:TMEM88
Interaction	MYB interactions	EZH2 EHMT2 ZNF281	4.46e-05	133	11	3	int:MYB
Interaction	MX2 interactions	EZH2 EHMT2	4.61e-05	19	11	2	int:MX2
Interaction	ZNF518B interactions	EZH2 EHMT2	6.22e-05	22	11	2	int:ZNF518B
Interaction	MYOD1 interactions	EZH2 EHMT2 ZNF281	1.37e-04	194	11	3	int:MYOD1
Interaction	PHIP interactions	EZH2 ZNF281 MCM3AP	1.43e-04	197	11	3	int:PHIP
Cytoband	2q37.3	AQP12A AQP12B	2.14e-04	77	13	2	2q37.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	ZFYVE26 ZDHHC22	1.43e-03	200	13	2	chr14q24
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	AQP12A AQP12B	1.82e-03	226	13	2	chr2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	EHMT2 SLC26A8	8.63e-03	503	13	2	chr6p21
GeneFamily	Aquaporins	AQP12A AQP12B	3.66e-05	14	12	2	305
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EZH2 EHMT2	2.24e-04	34	12	2	487
Coexpression	GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_2H_DN	EZH2 MICAL1 ZFYVE26	9.09e-05	183	13	3	M4289
Coexpression	GSE38681_WT_VS_LYL1_KO_LYMPHOID_PRIMED_MULTIPOTENT_PROGENITOR_DN	EZH2 ZNF281 ZFYVE26	1.18e-04	200	13	3	M9020
Coexpression	GSE17580_TREG_VS_TEFF_UP	EZH2 ZNF281 SCN11A	1.18e-04	200	13	3	M3670
Disease	Chromosome Breaks	EZH2 EHMT2	1.63e-05	14	13	2	C0333704
Disease	Chromosome Breakage	EZH2 EHMT2	1.63e-05	14	13	2	C0376628
Disease	esophagus squamous cell carcinoma (is_marker_for)	EZH2 EHMT2	4.75e-04	74	13	2	DOID:3748 (is_marker_for)
Disease	lung adenocarcinoma (is_marker_for)	EZH2 EHMT2	6.27e-04	85	13	2	DOID:3910 (is_marker_for)
Disease	Malignant neoplasm of breast	EZH2 ZNF281 MICAL1 ZFYVE26	9.59e-04	1074	13	4	C0006142
Disease	Neoplastic Cell Transformation	EZH2 EHMT2	1.66e-03	139	13	2	C0007621

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACAFCFHLTLLHLRH	AQP12A	156	Q8IXF9
CCEHARDFAHRCVLH	CALHM3	231	Q86XJ0
FLECHPDFRVAHRFH	EHMT2	506	Q96KQ7
ACAFCFHLTLLHLRH	AQP12B	156	A6NM10
CTRFHIHCAHFMCEE	MCM3AP	751	O60318
QSLHSFHTLFCRRCF	EZH2	276	Q15910
YCRSHVLSHAFCLHQ	OR51B6	166	Q9H340
CVNGHFFHRSCFRCH	MICAL1	711	Q8TDZ2
FFHRSCFRCHTCEAT	MICAL1	716	Q8TDZ2
FRHHVQCRCSWHRFL	SLC26A8	56	Q96RN1
ARVTLRHDHHCFFTG	ZDHHC22	101	Q8N966
HICDHCSAAFRSSYH	ZNF281	261	Q9Y2X9
RAFCFVRHTLEHFCH	SCN11A	841	Q9UI33
CCREHFTMFNRRHHC	ZFYVE26	1821	Q68DK2