Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLCO1B7 TRPV1 SLC22A16 TMEM165 SLC43A1 UCP2 SCN5A HTR3E AQP7B SLC9B1P1 CACNA1H AQP7P3 PKD1L3 ITGAV AQP7 CHRNA1 ATP4A TMEM63A	1.06e-07	1180	71	18	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLCO1B7 TRPV1 SLC22A16 TMEM165 SLC43A1 UCP2 SCN5A HTR3E AQP7B SLC9B1P1 CACNA1H AQP7P3 PKD1L3 ITGAV AQP7 CHRNA1 ATP4A TMEM63A	3.94e-07	1289	71	18	GO:0005215
GeneOntologyMolecularFunction	glycerol channel activity	AQP7B AQP7P3 AQP7	1.49e-06	7	71	3	GO:0015254
GeneOntologyMolecularFunction	channel activity	TRPV1 SCN5A HTR3E AQP7B CACNA1H AQP7P3 PKD1L3 ITGAV AQP7 CHRNA1 TMEM63A	2.30e-06	525	71	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPV1 SCN5A HTR3E AQP7B CACNA1H AQP7P3 PKD1L3 ITGAV AQP7 CHRNA1 TMEM63A	2.34e-06	526	71	11	GO:0022803
GeneOntologyMolecularFunction	urea transmembrane transporter activity	AQP7B AQP7P3 AQP7	3.56e-06	9	71	3	GO:0015204
GeneOntologyMolecularFunction	glycerol transmembrane transporter activity	AQP7B AQP7P3 AQP7	3.56e-06	9	71	3	GO:0015168
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR6B1 TRPV1 OR4N5 GPR173 GPR85 HTR3E OR4E2 OR4E1 C3AR1 CCR4 CCR6 CCR8 PKD1L3 CHRNA1 OR8U8 OR5D13 TMEM63A	3.77e-06	1353	71	17	GO:0004888
GeneOntologyMolecularFunction	chemokine binding	CCR4 CCR6 CCR8 ITGAV	5.55e-06	33	71	4	GO:0019956
GeneOntologyMolecularFunction	polyol transmembrane transporter activity	AQP7B AQP7P3 AQP7	1.20e-05	13	71	3	GO:0015166
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPV1 TMEM165 UCP2 SCN5A AQP7B CACNA1H AQP7P3 PKD1L3 ITGAV AQP7 ATP4A TMEM63A	1.34e-05	758	71	12	GO:0015318
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLCO1B7 AQP7B AQP7P3 AQP7	1.48e-05	42	71	4	GO:0042887
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPV1 TMEM165 UCP2 SCN5A HTR3E CACNA1H PKD1L3 ITGAV CHRNA1 ATP4A TMEM63A	2.11e-05	664	71	11	GO:0008324
GeneOntologyMolecularFunction	water channel activity	AQP7B AQP7P3 AQP7	2.83e-05	17	71	3	GO:0015250
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPV1 SCN5A HTR3E CACNA1H PKD1L3 ITGAV CHRNA1 TMEM63A	2.90e-05	343	71	8	GO:0005261
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP7B AQP7P3 AQP7	4.70e-05	20	71	3	GO:0005372
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR6B1 OR4N5 GPR173 GPR85 OR4E2 OR4E1 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	6.05e-05	884	71	12	GO:0004930
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR4 CCR6 CCR8	7.25e-05	23	71	3	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CCR4 CCR6 CCR8	8.26e-05	24	71	3	GO:0019957
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPV1 TMEM165 UCP2 SCN5A HTR3E CACNA1H PKD1L3 ITGAV CHRNA1 ATP4A TMEM63A	1.05e-04	793	71	11	GO:0015075
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR4 CCR6 CCR8	1.06e-04	26	71	3	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR4 CCR6 CCR8	1.06e-04	26	71	3	GO:0004950
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	SLCO1B7 AQP7B AQP7P3 AQP7	1.13e-04	70	71	4	GO:1901618
GeneOntologyMolecularFunction	urea channel activity	AQP7P3 AQP7	1.24e-04	5	71	2	GO:0015265
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPV1 TMEM165 CACNA1H PKD1L3 ITGAV	2.02e-04	151	71	5	GO:0015085
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPV1 SCN5A HTR3E CACNA1H PKD1L3 ITGAV CHRNA1 TMEM63A	2.20e-04	459	71	8	GO:0005216
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPV1 TMEM165 UCP2 SCN5A CACNA1H PKD1L3 ITGAV ATP4A TMEM63A	3.68e-04	627	71	9	GO:0022890
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	AQP7B AQP7P3 AQP7	4.48e-04	42	71	3	GO:0015144
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	TRPV1 HTR3E CHRNA1	4.80e-04	43	71	3	GO:0005231
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	TRPV1 CACNA1H ITGAV	5.86e-04	46	71	3	GO:0005245
GeneOntologyMolecularFunction	odorant binding	OR4E2 OR4E1 OR8U8 OR5D13	1.09e-03	127	71	4	GO:0005549
GeneOntologyMolecularFunction	calcium channel activity	TRPV1 CACNA1H PKD1L3 ITGAV	1.16e-03	129	71	4	GO:0005262
GeneOntologyMolecularFunction	gated channel activity	TRPV1 HTR3E CACNA1H ITGAV CHRNA1 TMEM63A	1.20e-03	334	71	6	GO:0022836
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPV1 TMEM165 SCN5A CACNA1H PKD1L3 ITGAV ATP4A	1.31e-03	465	71	7	GO:0046873
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TRPV1 HTR3E CHRNA1 TMEM63A	1.56e-03	140	71	4	GO:0099094
GeneOntologyMolecularFunction	cytokine binding	CCR4 CCR6 CCR8 ITGAV	2.37e-03	157	71	4	GO:0019955
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	TRPV1 HTR3E CHRNA1	2.61e-03	77	71	3	GO:0005230
GeneOntologyMolecularFunction	immune receptor activity	C3AR1 CCR4 CCR6 CCR8	2.84e-03	165	71	4	GO:0140375
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN5A CACNA1H	3.83e-03	26	71	2	GO:0005248
GeneOntologyMolecularFunction	fibroblast growth factor binding	SCN5A ITGAV	4.13e-03	27	71	2	GO:0017134
GeneOntologyMolecularFunction	olfactory receptor activity	OR6B1 OR4N5 OR4E2 OR4E1 OR8U8 OR5D13	4.29e-03	431	71	6	GO:0004984
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TRPV1 HTR3E CHRNA1 TMEM63A	4.96e-03	193	71	4	GO:0015276
GeneOntologyMolecularFunction	cytokine receptor activity	CCR4 CCR6 CCR8	5.00e-03	97	71	3	GO:0004896
GeneOntologyMolecularFunction	ligand-gated channel activity	TRPV1 HTR3E CHRNA1 TMEM63A	5.34e-03	197	71	4	GO:0022834
GeneOntologyBiologicalProcess	glycerol transmembrane transport	AQP7B AQP7P3 AQP7	3.10e-06	9	70	3	GO:0015793
GeneOntologyBiologicalProcess	polyol transmembrane transport	AQP7B AQP7P3 AQP7	8.06e-06	12	70	3	GO:0015791
GeneOntologyBiologicalProcess	urea transmembrane transport	AQP7B AQP7P3 AQP7	8.06e-06	12	70	3	GO:0071918
GeneOntologyBiologicalProcess	urea transport	AQP7B AQP7P3 AQP7	1.33e-05	14	70	3	GO:0015840
GeneOntologyBiologicalProcess	monoatomic ion transport	SLCO1B7 TRPV1 SLC22A16 TMEM165 UCP2 SCN5A HTR3E SLC9B1P1 CACNA1H GCG PKD1L3 ITGAV CHRNA1 ATP4A TMEM63A	4.65e-05	1374	70	15	GO:0006811
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR6B1 TRPV1 OR4N5 OR4E2 OR4E1 PKD1L3 ITGAV OR8U8 OR5D13	6.75e-05	524	70	9	GO:0009593
GeneOntologyBiologicalProcess	amide transport	SLCO1B7 TRPV1 CLTRN UCP2 AQP7B GCG AQP7P3 AQP7	8.66e-05	420	70	8	GO:0042886
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	TRPV1 C3AR1 CCR4 CCR6 CCR8 ITGAV	1.13e-04	224	70	6	GO:0007204
GeneOntologyBiologicalProcess	import across plasma membrane	TRPV1 CLTRN SLC43A1 SCN5A CACNA1H ATP4A	1.30e-04	230	70	6	GO:0098739
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR6B1 TRPV1 OR4N5 OR4E2 OR4E1 PKD1L3 PPEF1 OR8U8 OR5D13	1.50e-04	582	70	9	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR6B1 TRPV1 OR4N5 OR4E2 OR4E1 PKD1L3 PPEF1 ITGAV OR8U8 OR5D13	1.54e-04	722	70	10	GO:0051606
GeneOntologyBiologicalProcess	water transport	AQP7B AQP7P3 AQP7	1.73e-04	32	70	3	GO:0006833
GeneOntologyBiologicalProcess	one-carbon compound transport	AQP7B AQP7P3 AQP7	1.90e-04	33	70	3	GO:0019755
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR6B1 TRPV1 OR4N5 OR4E2 OR4E1 PKD1L3 OR8U8 OR5D13	2.32e-04	485	70	8	GO:0050907
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	TRPV1 TMEM165 UCP2 SCN5A HTR3E SLC9B1P1 CACNA1H PKD1L3 ITGAV CHRNA1 ATP4A TMEM63A	3.41e-04	1115	70	12	GO:0034220
GeneOntologyBiologicalProcess	fluid transport	AQP7B AQP7P3 AQP7	3.91e-04	42	70	3	GO:0042044
GeneOntologyBiologicalProcess	monoatomic cation transport	TRPV1 TMEM165 UCP2 SCN5A SLC9B1P1 CACNA1H GCG PKD1L3 ITGAV CHRNA1 ATP4A TMEM63A	4.76e-04	1157	70	12	GO:0006812
GeneOntologyBiologicalProcess	renal water absorption	AQP7P3 AQP7	5.02e-04	10	70	2	GO:0070295
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR6B1 TRPV1 OR4N5 OR4E2 OR4E1 PKD1L3 OR8U8 OR5D13	5.18e-04	547	70	8	GO:0007606
MousePheno	decreased urine glycerol level	AQP7P3 AQP7	1.31e-05	2	51	2	MP:0030781
MousePheno	abnormal urine glycerol level	AQP7P3 AQP7	3.91e-05	3	51	2	MP:0030782
Domain	Histatin/statherin	HTN1 HTN3 STATH	4.21e-08	3	66	3	IPR030773
Domain	GPCR_Rhodpsn_7TM	OR6B1 OR4N5 GPR173 GPR85 OR4E2 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	2.08e-05	670	66	11	IPR017452
Domain	Chemokine_rcpt	CCR4 CCR6 CCR8	2.28e-05	16	66	3	IPR000355
Domain	7tm_1	OR6B1 OR4N5 GPR173 GPR85 OR4E2 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	2.29e-05	677	66	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6B1 OR4N5 GPR173 GPR85 OR4E2 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	2.55e-05	685	66	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6B1 OR4N5 GPR173 GPR85 OR4E2 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	2.76e-05	691	66	11	PS50262
Domain	GPCR_Rhodpsn	OR6B1 OR4N5 GPR173 GPR85 OR4E2 C3AR1 CCR4 CCR6 CCR8 OR8U8 OR5D13	2.80e-05	692	66	11	IPR000276
Domain	ATII_AT1_rcpt	CCR4 CCR6	3.68e-05	3	66	2	IPR000190
Domain	-	HTR3E CHRNA1	2.97e-03	23	66	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	HTR3E CHRNA1	2.97e-03	23	66	2	IPR027361
Domain	Ion_trans_dom	TRPV1 SCN5A CACNA1H	7.67e-03	114	66	3	IPR005821
Domain	Ion_trans	TRPV1 SCN5A CACNA1H	7.67e-03	114	66	3	PF00520
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OR6B1 GPR173 GPR85 C3AR1 CCR4 CCR6 CCR8	5.66e-05	260	54	7	M39397
Pathway	WP_GPCRS_PEPTIDE	C3AR1 CCR4 CCR6 CCR8	1.46e-04	70	54	4	MM15959
Pathway	WP_PEPTIDE_GPCRS	C3AR1 CCR4 CCR6 CCR8	1.91e-04	75	54	4	M39696
Pubmed	Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.	HTN1 HTN3 STATH	3.26e-08	4	71	3	10728974
Pubmed	Two-hybrid analysis of human salivary mucin MUC7 interactions.	HTN1 HTN3 STATH	6.79e-07	9	71	3	16203048
Pubmed	Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.	CCR4 CCR8	4.11e-06	2	71	2	19062085
Pubmed	Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.	AQP7P3 AQP7	4.11e-06	2	71	2	23290745
Pubmed	Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.	HTN1 HTN3	4.11e-06	2	71	2	2372245
Pubmed	Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.	HTN1 STATH	4.11e-06	2	71	2	12060866
Pubmed	Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.	HTN1 HTN3	4.11e-06	2	71	2	12711380
Pubmed	Uncoupling protein 2 negatively regulates glucose-induced glucagon-like peptide 1 secretion.	UCP2 GCG	4.11e-06	2	71	2	22257551
Pubmed	Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.	HTN3 STATH	4.11e-06	2	71	2	3426601
Pubmed	Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.	HTN1 HTN3	4.11e-06	2	71	2	32225006
Pubmed	Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).	HTN1 HTN3	4.11e-06	2	71	2	2719677
Pubmed	Over-expression of AQP7 contributes to improve insulin resistance in adipocytes.	AQP7P3 AQP7	4.11e-06	2	71	2	22877989
Pubmed	Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.	HTN1 HTN3	4.11e-06	2	71	2	18650243
Pubmed	TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice.	TRPV1 UCP2	4.11e-06	2	71	2	22395410
Pubmed	Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.	AQP7P3 AQP7	4.11e-06	2	71	2	32631905
Pubmed	Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.	HTN1 HTN3	4.11e-06	2	71	2	3286634
Pubmed	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.	AQP7P3 AQP7	4.11e-06	2	71	2	11457862
Pubmed	Molecular cloning and RNA expression of two new human chemokine receptor-like genes.	CCR6 CCR8	4.11e-06	2	71	2	8886020
Pubmed	Mutually exclusive expression of odorant receptor transgenes.	OR4E2 OR4E1	4.11e-06	2	71	2	10862701
Pubmed	Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.	AQP7P3 AQP7	4.11e-06	2	71	2	37691043
Pubmed	Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.	AQP7P3 AQP7	4.11e-06	2	71	2	37879294
Pubmed	Aquaporin7 expression during perinatal development of mouse brain.	AQP7P3 AQP7	4.11e-06	2	71	2	17052846
Pubmed	Prolonged Starvation Causes Up-Regulation of AQP1 in Adipose Tissue Capillaries of AQP7 Knock-Out Mice.	AQP7P3 AQP7	4.11e-06	2	71	2	27455244
Pubmed	Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.	AQP7P3 AQP7	4.11e-06	2	71	2	21968069
Pubmed	Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels.	TRPV1 CACNA1H	4.11e-06	2	71	2	29289470
Pubmed	Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells.	UCP2 GCG	4.11e-06	2	71	2	22807616
Pubmed	Structural relationship between human salivary histatins.	HTN1 HTN3	4.11e-06	2	71	2	2303595
Pubmed	Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice.	AQP7P3 AQP7	4.11e-06	2	71	2	17123523
Pubmed	Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.	AQP7P3 AQP7	4.11e-06	2	71	2	11972053
Pubmed	Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.	HTN1 HTN3	4.11e-06	2	71	2	8336540
Pubmed	Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's).	CCR4 CCR6	4.11e-06	2	71	2	22490506
Pubmed	Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.	AQP7P3 AQP7	4.11e-06	2	71	2	15591341
Pubmed	Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.	AQP7P3 AQP7	4.11e-06	2	71	2	37432580
Pubmed	CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal B16 melanoma.	CCR4 CCR6	4.11e-06	2	71	2	27132989
Pubmed	Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.	AQP7P3 AQP7	4.11e-06	2	71	2	17576812
Pubmed	TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction.	TRPV1 UCP2	4.11e-06	2	71	2	23607427
Pubmed	Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.	AQP7P3 AQP7	4.11e-06	2	71	2	15746100
Pubmed	Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.	AQP7P3 AQP7	4.11e-06	2	71	2	26634435
Pubmed	Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.	HTN1 HTN3	4.11e-06	2	71	2	2773933
Pubmed	Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.	OR4E2 OR4E1	4.11e-06	2	71	2	14593185
Pubmed	Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization.	AQP7P3 AQP7	4.11e-06	2	71	2	21130427
Pubmed	Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb.	OR4E2 OR4E1	4.11e-06	2	71	2	10493742
Pubmed	The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.	AQP7P3 AQP7	4.11e-06	2	71	2	19297367
Pubmed	AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism.	AQP7P3 AQP7	4.11e-06	2	71	2	17077387
Pubmed	Dynamic subcellular localization of aquaporin-7 in white adipocytes.	AQP7P3 AQP7	4.11e-06	2	71	2	25643985
Pubmed	Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.	AQP7P3 AQP7	4.11e-06	2	71	2	9714739
Pubmed	The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis.	CCR4 CCR6	4.11e-06	2	71	2	23477966
Pubmed	A new role for aquaporin 7 in insulin secretion.	AQP7P3 AQP7	4.11e-06	2	71	2	22415076
Pubmed	A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.	CCR4 CCR6 CCR8	1.06e-05	21	71	3	16129397
Pubmed	Use of (alternative) coreceptors for HIV entry.	CCR4 CCR6 CCR8	1.06e-05	21	71	3	22842622
Pubmed	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.	AQP7P3 AQP7	1.23e-05	3	71	2	12351427
Pubmed	UCP2 regulates the glucagon response to fasting and starvation.	UCP2 GCG	1.23e-05	3	71	2	23434936
Pubmed	Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes.	AQP7P3 AQP7	1.23e-05	3	71	2	20573496
Pubmed	Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis.	CCR4 CCR8	1.23e-05	3	71	2	16239514
Pubmed	Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus.	CCR4 CCR6	1.23e-05	3	71	2	20334681
Pubmed	Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.	AQP7P3 AQP7	1.23e-05	3	71	2	15998844
Pubmed	Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.	AQP7P3 AQP7	1.23e-05	3	71	2	16009937
Pubmed	Adipocyte lipolysis drives acute stress-induced insulin resistance.	AQP7P3 AQP7	1.23e-05	3	71	2	33097799
Pubmed	Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.	AQP7P3 AQP7	1.23e-05	3	71	2	38064372
Pubmed	Channel-dependent permeation of water and glycerol in mouse morulae.	AQP7P3 AQP7	1.23e-05	3	71	2	16339044
Pubmed	Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle.	AQP7P3 AQP7	1.23e-05	3	71	2	27746040
Pubmed	Chemokine receptor requirements for epidermal T-cell trafficking.	CCR4 CCR6	1.23e-05	3	71	2	21641376
Pubmed	Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.	HTN1 HTN3	1.23e-05	3	71	2	35489730
Pubmed	An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.	GPR173 GPR85	1.23e-05	3	71	2	10833454
Pubmed	Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.	AQP7P3 AQP7	1.23e-05	3	71	2	18829704
Pubmed	In Vitro Identification of Histatin 5 Salivary Complexes.	HTN1 HTN3 STATH	2.30e-05	27	71	3	26544073
Pubmed	TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.	TRPV1 CACNA1H	2.46e-05	4	71	2	27974205
Pubmed	Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.	AQP7P3 AQP7	2.46e-05	4	71	2	11952783
Pubmed	LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.	AQP7P3 AQP7	2.46e-05	4	71	2	34807469
Pubmed	The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.	AQP7P3 AQP7	2.46e-05	4	71	2	19005169
Pubmed	Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus.	AQP7P3 AQP7	2.46e-05	4	71	2	29890131
Pubmed	Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease.	CCR4 CCR6	2.46e-05	4	71	2	28392462
Pubmed	T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension.	PTPA CACNA1H	2.46e-05	4	71	2	28655554
Pubmed	Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.	AQP7P3 AQP7	2.46e-05	4	71	2	17245390
Pubmed	Dissociation of heterotrimeric g proteins in cells.	C3AR1 CCR4 GCG CCR6 CCR8	3.38e-05	179	71	5	18577758
Pubmed	IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.	CCR4 CCR8	4.09e-05	5	71	2	25264308
Pubmed	Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.	CCR6 ITGAV	4.09e-05	5	71	2	21646718
Pubmed	More than just water channels: unexpected cellular roles of aquaporins.	AQP7P3 AQP7	4.09e-05	5	71	2	16079275
Pubmed	Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins.	HTN1 STATH	4.09e-05	5	71	2	9109822
Pubmed	Local and cis effects of the H element on expression of odorant receptor genes in mouse.	OR4E2 OR4E1	4.09e-05	5	71	2	17662950
Pubmed	Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.	AQP7P3 AQP7	6.13e-05	6	71	2	12351183
Pubmed	A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation.	CCR4 CCR8	6.13e-05	6	71	2	31537642
Pubmed	Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis.	UCP2 GCG	6.13e-05	6	71	2	15056934
Pubmed	Role of aquaporin water channels in kidney and lung.	AQP7P3 AQP7	8.57e-05	7	71	2	9822113
Pubmed	Lessons on renal physiology from transgenic mice lacking aquaporin water channels.	AQP7P3 AQP7	8.57e-05	7	71	2	10232700
Pubmed	Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.	TRPV1 UCP2	1.47e-04	9	71	2	19056576
Pubmed	Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.	CLTRN GCG	1.47e-04	9	71	2	16330324
Pubmed	Aquaporin molecular biology and clinical abnormalities of the water transport channels.	AQP7P3 AQP7	1.47e-04	9	71	2	9757370
Pubmed	Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.	CCR6 CCR8	1.47e-04	9	71	2	22729248
Pubmed	Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.	CCR4 CCR6	1.47e-04	9	71	2	12070001
Pubmed	Transcriptome analysis of human gastric cancer.	TRMT10C GLE1 ZG16B TMEM147 TSPAN4 SIM2 TRAPPC1 PTCD3	1.76e-04	772	71	8	16341674
Pubmed	Expression of mRNAs of the aquaporin family in mouse oocytes and embryos.	AQP7P3 AQP7	1.83e-04	10	71	2	10788316
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PTPA STAG2	1.83e-04	10	71	2	23242214
Pubmed	Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.	AQP7P3 AQP7	1.83e-04	10	71	2	12031518
Pubmed	mRNAs encoding aquaporins are present during murine preimplantation development.	AQP7P3 AQP7	1.83e-04	10	71	2	11066060
Pubmed	Mitochondrial Protein UCP2 Controls Pancreas Development.	UCP2 GCG	2.23e-04	11	71	2	29079704
Pubmed	Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.	OR4E2 OR4E1	2.68e-04	12	71	2	9110172
Pubmed	Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.	TRPV1 GCG	2.68e-04	12	71	2	29910119
Pubmed	Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture.	TRPV1 GCG	3.16e-04	13	71	2	26494286
Pubmed	Enhancer interaction networks as a means for singular olfactory receptor expression.	OR4E2 OR4E1	3.68e-04	14	71	2	25417106
Cytoband	19q13.1	FBL TMEM147 ATP4A	8.78e-05	55	71	3	19q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	CMTM6 SCN5A CCR4 CCR8	1.97e-04	184	71	4	chr3p22
Cytoband	4q13	HTN1 HTN3	2.44e-04	15	71	2	4q13
Cytoband	Xp22	CLTRN PPEF1	6.91e-04	25	71	2	Xp22
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	PTPA GLE1 MYMK QSOX2	1.65e-03	325	71	4	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	HTN1 HTN3 STATH	1.89e-03	157	71	3	chr4q13
Cytoband	11q11	OR8U8 OR5D13	2.44e-03	47	71	2	11q11
Cytoband	14q11.2	OR4N5 OR4E2 OR4E1	2.79e-03	180	71	3	14q11.2
GeneFamily	Histatins and statherin	HTN1 HTN3 STATH	1.65e-08	3	47	3	971
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR4 CCR6 CCR8	1.95e-06	10	47	3	1091
ToppCell	facs-Lung-EPCAM-24m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN FHOD3 GCG CHRNA1	6.33e-06	76	70	4	98271aadf026a01bf933f8279d11a0413e47d549
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN FHOD3 GCG CHRNA1	6.67e-06	77	70	4	557f7518e9a89d99f3f2474720deb9cde10e1054
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTRN FHOD3 GCG CHRNA1	7.77e-06	80	70	4	6720438bf51831e98402a700dfc25bd57e0c6798
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSPG5 SCN5A FHOD3 CACNA1H PKD1L3	8.29e-06	175	70	5	28b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSPG5 SCN5A FHOD3 CACNA1H PKD1L3	8.29e-06	175	70	5	ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCell	Severe-Treg\|Severe / Disease group and Cell class	CMTM6 UCP2 CCR4 CCR6 CCR8	1.36e-05	194	70	5	7d232d87262ec5f505901345da5113cabf821321
ToppCell	CV-Moderate-5\|CV / Virus stimulation, Condition and Cluster	FBL TKT TMEM147 CCR4 CCR8	1.40e-05	195	70	5	7a0bb304c659dd108b75d0c5d19eca5e63cf856d
Disease	QRS complex, QRS duration	TKT SCN5A FHOD3	1.42e-04	45	66	3	EFO_0005054, EFO_0005055
Disease	asthma (biomarker_via_orthology)	C3AR1 CCR4 CCR8	3.18e-04	59	66	3	DOID:2841 (biomarker_via_orthology)
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	COG6 CCR6 PHTF1	3.86e-04	63	66	3	EFO_0000685, EFO_0007791, EFO_0009459
Disease	colorectal mucinous adenocarcinoma	PTPA SLC22A16	5.79e-04	16	66	2	EFO_0009361
Disease	blood metabolite measurement	PTPA SLC22A16	8.22e-04	19	66	2	EFO_0005664
Disease	Immunosuppressant use measurement	CCR6 PHTF1	1.01e-03	21	66	2	EFO_0009934
Disease	cervical squamous cell carcinoma (is_marker_for)	BRIP1 CCR4	1.11e-03	22	66	2	DOID:3744 (is_marker_for)
Disease	Obesity	TRPV1 UCP2 GCG AQP7	1.16e-03	205	66	4	C0028754
Disease	Hyperinsulinism	UCP2 GCG	1.79e-03	28	66	2	C0020459

Protein segments in the cluster

Peptide	Gene	Start	Entry
DHFMKIFLYCRRAMV	CFAP54	1611	Q96N23
MKHFLRMLIQVCLYF	ELMOD1	1	Q8N336
LFMMTVFFAKKLYLL	CSPG5	436	O95196
MDAMLFRLYLLFMAS	HTR3E	431	A5X5Y0
KFAADVRLMFMNCYK	BRDT	336	Q58F21
PLMFMIFCYTFIVKT	CCR6	226	P51684
FLKRMSGMIRLYAAI	GLE1	566	Q53GS7
FFVMLMSIDRYLAIV	CCR4	126	P51679
ILFGFLALSTMRMKY	DPY19L3	471	Q6ZPD9
IMIACYSFIVFRMQR	C3AR1	351	Q16581
SSLFLMVMYFFFRVR	QSOX2	671	Q6ZRP7
KYMLFTMVFVIASII	CHRNA1	296	P02708
VSYMFIIFAILRMSS	OR8U8	216	P0C7N1
FIIYDIMNELMGKRF	PTCD3	391	Q96EY7
LMKMIRDFSILFYRC	NEIL3	221	Q8TAT5
RKMAREFLAEFMSTY	AQP7P3	31	A6NL99
KMVREFLAEFMSTYV	AQP7B	36	A0A075B734
LRIIFYMAAVNKMLE	SLC43A1	316	O75387
EMFLLVVMAFDRYIA	OR4N5	111	Q8IXE1
HKYRMLIAMVDVIFA	FBL	221	P22087
MALIRKTFYFLFAMF	DEFB105A	1	Q8NG35
KMVLATCSSYFRAMF	KBTBD2	46	Q8IY47
AMAFLMLTERKILGY	MT-ND1	16	P03886
MKSIYFVAGLFVMLV	GCG	1	P01275
RKMVREFLAEFMSTY	AQP7	31	O14520
YTFRMIMAKTAADRR	TMEM63A	581	O94886
MLKGLFMVLDYLFRQ	BRIP1	526	Q9BX63
YMMKTTLALFEFTDR	COG6	506	Q9Y2V7
VRVVQSMARFMAAYF	CPLANE1	936	Q9H799
FDVMFLRYGKMLVQA	DNAH3	2236	Q8TD57
LAVIKFSDSNYMRML	DNAH3	3101	Q8TD57
MFFITLMSVDRYLAV	CCR8	121	P51685
LVFVMYRMGFFKRVR	ITGAV	1011	P06756
LFSFYAKMPMERKAL	CENPT	466	Q96BT3
ILTNKRFMLDMLYAH	FHOD3	671	Q2V2M9
AFMLFCISVTRYMAI	GPR173	111	Q9NS66
MKFFVFALILALMLS	HTN3	1	P15516
KRISRMFYIMTFLFL	GPR85	281	P60893
AFIFAFFAVEMVIKM	CACNA1H	141	O95180
DSKYFSRGIMMAILV	CACNA1H	791	O95180
MKFFVFALVLALMIS	HTN1	1	P15515
YTFLRAMVFFMAIVV	ATP4A	326	P20648
TFMAAVMLVAFYKLR	LRRC4B	586	Q9NT99
MLAAMAYDRFVAVCK	OR5D13	116	Q8NGL4
DFMMNLRYGFTKEIL	PPEF1	236	O14829
MKFLVFAFILALMVS	STATH	1	P02808
TYAKDVMTVAFLAIM	SLC9B1P1	231	A6NJY1
RCFDFFIDYMVLLKM	SAMD9L	1266	Q8IVG5
YTFMAARFFLAMVAS	SLC22A16	206	Q86VW1
KVVFFTFLYSLMMSR	PKD1L3	1206	Q7Z443
TLRSAGKIYMIFFML	SCN5A	381	Q14524
AITEIKLYSNMFMFR	SIM2	221	Q14190
KLYSNMFMFRASLDL	SIM2	226	Q14190
LSLSFKLDYFSMMFI	MT-ND5	76	P03915
AFMLGSLFAKMYVDI	SLCO1B7	176	G3V0H7
LSMRAAMFLIFLVAY	OR6B1	21	O95007
FMFLLDFITMLYEKR	CMTM6	146	Q9NX76
EEYLFKAMVAFSMRK	CLTRN	46	Q9HBJ8
KLMYGMLFSIRSFVS	TRAPPC1	36	Q9Y5R8
FQAFLRGMVMYTSKD	ZG16B	126	Q96DA0
VMFVTYEQLKRALMA	UCP2	286	P55851
IFTKMAVVRYMFFNR	TSR1	706	Q2NL82
KARIAMFSMFLIFYV	OR4E1	26	P0C645
RVLEMLFFMAFSAIY	OR4E2	21	Q8NGC2
EIMAVLFFHTMRYKS	TKT	46	P29401
FMMCVAERTYKQRFL	PHTF1	546	Q9UMS5
KMILRDLCRFMFVYI	TRPV1	571	Q8NER1
YLEKFMTFQMSLRRE	STAG2	1021	Q8N3U4
GMKVFFMVVAAVYIL	TMEM181	456	Q9P2C4
YMFLECILFITEMKT	PTPA	286	Q15257
DKTFFIAAIMAMRYN	TMEM165	111	Q9HC07
MLYSFFMPAAKLKER	UBA1	996	P22314
MARACLQAVKYLMFA	TSPAN4	1	O14817
LLMFLSVYKAFVMET	TMEM147	171	Q9BVK8
MAAFLKMSVSVNFFR	TRMT10C	1	Q7L0Y3
AKRRFHMEAMVYLFT	MYMK	26	A6NI61