Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalmodulin binding

PCP4 MYO6 MYO7A PSG6 MAPKAPK2 ASPM KCNQ1

5.65e-05230857GO:0005516
GeneOntologyBiologicalProcesscerebral cortex development

FAT4 SRGAP2C HIF1A ASPM POU3F2 POU3F3 SRGAP2

2.32e-06147847GO:0021987
GeneOntologyBiologicalProcessextension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

SRGAP2C SRGAP2

1.64e-052842GO:0021816
GeneOntologyBiologicalProcesscerebral cortex radially oriented cell migration

SRGAP2C POU3F2 POU3F3 SRGAP2

2.55e-0542844GO:0021799
GeneOntologyBiologicalProcessforebrain development

FAT4 SRGAP2C HIF1A ASPM POU3F1 POU3F2 POU3F3 POU3F4 SRGAP2 CHD7

2.94e-054898410GO:0030900
GeneOntologyBiologicalProcesspallium development

FAT4 SRGAP2C HIF1A ASPM POU3F2 POU3F3 SRGAP2

3.41e-05222847GO:0021543
GeneOntologyBiologicalProcessnegative regulation of phospholipase A2 activity

ANXA8L1 ANXA8

4.90e-053842GO:1900138
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

COCH MYO6 MYO7A SCN10A KCNQ1 POU3F4 CHD7

5.31e-05238847GO:0050954
GeneOntologyBiologicalProcesstelencephalon development

FAT4 SRGAP2C HIF1A ASPM POU3F2 POU3F3 SRGAP2 CHD7

6.24e-05332848GO:0021537
GeneOntologyBiologicalProcessinner ear development

FAT4 MYO6 MYO7A MAPKAPK2 KCNQ1 POU3F4 CHD7

7.80e-05253847GO:0048839
GeneOntologyBiologicalProcesscerebral cortex cell migration

SRGAP2C POU3F2 POU3F3 SRGAP2

8.00e-0556844GO:0021795
GeneOntologyBiologicalProcesscell differentiation involved in metanephros development

FAT4 WNT9B POU3F3

9.49e-0522843GO:0072202
GeneOntologyBiologicalProcessmetanephric tubule development

FAT4 WNT9B POU3F3

1.58e-0426843GO:0072170
GeneOntologyBiologicalProcesssensory perception of sound

COCH MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.58e-04198846GO:0007605
GeneOntologyBiologicalProcessmodulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

SRGAP2C SRGAP2

1.63e-045842GO:0021815
GeneOntologyBiologicalProcessregulation of asymmetric cell division

WNT9B ASPM

1.63e-045842GO:0009786
GeneOntologyBiologicalProcessnegative regulation of phospholipase activity

ANXA8L1 ANXA8

1.63e-045842GO:0010519
GeneOntologyBiologicalProcessear development

FAT4 MYO6 MYO7A MAPKAPK2 KCNQ1 POU3F4 CHD7

1.63e-04285847GO:0043583
GeneOntologyBiologicalProcessbrain development

FAT4 SRGAP2C HIF1A WNT9B ASPM POU3F1 POU3F2 POU3F3 POU3F4 SRGAP2 CHD7 PBX2

1.80e-048598412GO:0007420
GeneOntologyBiologicalProcessinner ear morphogenesis

MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.84e-04129845GO:0042472
GeneOntologyBiologicalProcessmetanephric epithelium development

FAT4 WNT9B POU3F3

1.98e-0428843GO:0072207
GeneOntologyBiologicalProcesstelencephalon cell migration

SRGAP2C POU3F2 POU3F3 SRGAP2

2.13e-0472844GO:0022029
GeneOntologyBiologicalProcessforebrain ventricular zone progenitor cell division

POU3F2 POU3F3

2.43e-046842GO:0021869
GeneOntologyBiologicalProcessforebrain cell migration

SRGAP2C POU3F2 POU3F3 SRGAP2

2.50e-0475844GO:0021885
GeneOntologyBiologicalProcessfilopodium assembly

SRGAP2C ABITRAM SRGAP2 NLGN1

2.90e-0478844GO:0046847
GeneOntologyBiologicalProcesscentral nervous system development

FAT4 SRGAP2C HIF1A WNT9B ASPM POU3F1 POU3F2 POU3F3 POU3F4 SPG11 SRGAP2 CHD7 PBX2 ABCB1

3.18e-0411978414GO:0007417
GeneOntologyBiologicalProcesshead development

FAT4 SRGAP2C HIF1A WNT9B ASPM POU3F1 POU3F2 POU3F3 POU3F4 SRGAP2 CHD7 PBX2

3.35e-049198412GO:0060322
GeneOntologyBiologicalProcesscell motility involved in cerebral cortex radial glia guided migration

SRGAP2C SRGAP2

3.40e-047842GO:0021814
GeneOntologyBiologicalProcessear morphogenesis

MYO6 MYO7A KCNQ1 POU3F4 CHD7

4.18e-04154845GO:0042471
GeneOntologyBiologicalProcessnegative regulation of serine-type peptidase activity

ANXA8L1 ANXA8

4.52e-048842GO:1902572
GeneOntologyBiologicalProcessnegative regulation of serine-type endopeptidase activity

ANXA8L1 ANXA8

4.52e-048842GO:1900004
GeneOntologyBiologicalProcessembryonic organ development

HIF1A CDC40 MYO6 MYO7A WNT9B KCNQ1 POU3F4 CHD7 PBX2

4.59e-04561849GO:0048568
GeneOntologyBiologicalProcessembryonic organ morphogenesis

HIF1A MYO6 MYO7A WNT9B KCNQ1 POU3F4 CHD7

5.74e-04351847GO:0048562
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

FAT4 MYO6 MYO7A KCNQ1

6.40e-0496844GO:0060113
MousePhenohead tossing

MYO6 MYO7A KCNQ1 POU3F4 CHD7

8.45e-0735715MP:0005307
MousePhenoimpaired swimming

MYO6 MYO7A KCNQ1 POU3F4 CHD7 LYST

3.09e-0680716MP:0001522
MousePhenohead shaking

MYO6 MYO7A POU3F4 CHD7

4.17e-0622714MP:0002730
MousePhenoabnormal vestibular system physiology

COCH MYO6 MYO7A POU3F4 LYST

4.70e-0649715MP:0004742
MousePhenohead bobbing

MYO6 MYO7A KCNQ1 POU3F4 CHD7

5.74e-0651715MP:0001410
MousePhenoabnormal pinna reflex

OARD1 MYO6 MYO7A KCNQ1 POU3F4 BIN2

1.20e-05101716MP:0001485
MousePhenoabnormal linear vestibular evoked potential

COCH MYO6 MYO7A POU3F4

1.52e-0530714MP:0004812
MousePhenoabnormal crista ampullaris neuroepithelium morphology

MYO6 KCNQ1 CHD7

2.01e-0511713MP:0004409
MousePhenoretropulsion

MYO6 MYO7A KCNQ1

3.46e-0513713MP:0010323
MousePhenoabnormal stria vascularis morphology

MYO6 MYO7A KCNQ1 POU3F4

7.11e-0544714MP:0000048
MousePhenoabnormal stapes footplate morphology

POU3F4 CHD7

7.61e-053712MP:0004290
MousePhenoabsent pinna reflex

OARD1 MYO6 MYO7A KCNQ1 BIN2

8.74e-0589715MP:0006358
MousePhenoabnormal stationary movement

MYO6 MYO7A SCN10A KCNQ1 POU3F4 CHD7

9.96e-05147716MP:0001388
MousePhenoabsent linear vestibular evoked potential

MYO6 MYO7A POU3F4

1.35e-0420713MP:0004813
MousePhenoabnormal cochlear outer hair cell morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.53e-04159716MP:0004399
MousePhenoneuron degeneration

MYO6 MYO7A FOLH1 GUCY2D KCNQ1 POU3F4 SPG11 ABCB1 SORL1

1.54e-04391719MP:0003224
MousePhenoabnormal head movements

MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.74e-04103715MP:0000436
MousePhenoabnormal vestibular hair cell stereociliary bundle morphology

MYO6 MYO7A KCNQ1

1.80e-0422713MP:0004515
MousePhenoabnormal semicircular canal morphology

MYO6 KCNQ1 POU3F4 CHD7

2.25e-0459714MP:0002428
MousePhenoabnormal circulating potassium level

ATP6V0A1 MYO6 POU3F3 POU3F4 CHD7 ABHD8

2.28e-04171716MP:0002668
MousePhenobidirectional circling

MYO6 KCNQ1 CHD7

2.35e-0424713MP:0001395
MousePhenoabnormal orientation of outer hair cell stereociliary bundles

FAT4 MYO6 MYO7A

2.35e-0424713MP:0004491
MousePhenoabnormal oval window morphology

POU3F4 CHD7

2.52e-045712MP:0004479
MousePhenoabnormal incus short process morphology

POU3F3 CHD7

2.52e-045712MP:0030394
MousePhenoabnormal stapes crus morpholgy

POU3F4 CHD7

2.52e-045712MP:0030407
MousePhenoabnormal cochlear nerve compound action potential

MYO6 MYO7A CHD7

2.67e-0425713MP:0004415
MousePhenoabnormal inner ear canal morphology

MYO6 KCNQ1 POU3F4 CHD7

2.90e-0463714MP:0002729
MousePhenocircling

MYO6 MYO7A KCNQ1 POU3F4 CHD7

3.16e-04117715MP:0001394
MousePhenoabnormal glial cell morphology

MYO7A FOLH1 ASPM POU3F1 POU3F2 SPG11 CHD7 LYST

3.49e-04345718MP:0003634
MousePhenoabnormal crista ampullaris morphology

MYO6 KCNQ1 CHD7

3.76e-0428713MP:0004249
MousePhenoabnormal potassium level

ATP6V0A1 MYO6 POU3F3 POU3F4 CHD7 ABHD8

4.73e-04196716MP:0020887
MousePhenoabnormal neuron number

ATP6V0A1 MYO6 MYO7A GUCY2D ASPM KCNQ1 POU3F2 CHD7 LYST

4.78e-04456719MP:0008946
MousePhenoabnormal potassium ion homeostasis

ATP6V0A1 MYO6 POU3F3 POU3F4 CHD7 ABHD8

4.99e-04198716MP:0011978
MousePhenoabnormal stapes morphology

POU3F3 POU3F4 CHD7

5.10e-0431713MP:0005107
MousePhenoutricular macular degeneration

MYO6 KCNQ1

5.25e-047712MP:0004334
MousePhenocatalepsy

SCN10A ABCB1

5.25e-047712MP:0002822
MousePhenoabnormal cochlear hair cell morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

5.55e-04202716MP:0002622
MousePhenoabnormal temporal bone petrous part morphology

POU3F3 POU3F4 CHD7

5.60e-0432713MP:0030319
MousePhenoabnormal semicircular canal ampulla morphology

MYO6 KCNQ1 CHD7

5.60e-0432713MP:0008488
MousePhenoneurodegeneration

MYO6 MYO7A FOLH1 GUCY2D KCNQ1 POU3F4 SPG11 ABCB1 SORL1

5.77e-04468719MP:0002229
MousePhenoabnormal cochlear sensory epithelium morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

6.31e-04207716MP:0003308
MousePhenoabnormal limbic system morphology

ATP6V0A1 FOLH1 POU3F2 POU3F3 SPG11 CHD7 LYST ABCB1

6.38e-04378718MP:0004166
MousePhenoabnormal organ of Corti morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

6.63e-04209716MP:0000042
MousePhenoabnormal neural crest cell migration

HIF1A PKN2 CHD7

6.71e-0434713MP:0002950
MousePhenoabnormal vestibular labyrinth morphology

MYO6 MYO7A KCNQ1 POU3F4

7.22e-0480714MP:0004427
MousePhenoabnormal orientation of cochlear hair cell stereociliary bundles

FAT4 MYO6 MYO7A

7.31e-0435713MP:0004522
MousePhenoabnormal hair cell morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

7.51e-04214716MP:0000045
MousePhenoabnormal inner ear vestibule morphology

MYO6 MYO7A KCNQ1 CHD7

7.57e-0481714MP:0000034
MousePhenodecreased kidney cell proliferation

FAT4 POU3F3

8.95e-049712MP:0011441
MousePhenoabnormal distortion product otoacoustic emission

COCH MYO7A KCNQ1 CHD7

9.07e-0485714MP:0004736
MousePhenoabnormal susceptibility to hearing loss

MYO7A CHD7 ABCB1

9.32e-0438713MP:0006334
MousePhenosensorineural hearing impairment

MYO7A POU3F4 CHD7

9.32e-0438713MP:0006329
MousePhenocochlear outer hair cell degeneration

MYO6 MYO7A KCNQ1 POU3F4

9.48e-0486714MP:0004404
MousePhenoabnormal otoacoustic response

COCH MYO7A KCNQ1 CHD7

9.48e-0486714MP:0006336
MousePhenothin stria vascularis

MYO7A KCNQ1

1.11e-0310712MP:0004364
MousePhenoabsent cochlear microphonics

MYO7A CHD7

1.11e-0310712MP:0004413
MousePhenospinning

MYO7A KCNQ1

1.11e-0310712MP:0001411
MousePhenoabnormal mechanoreceptor morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.12e-03231716MP:0000972
MousePhenoabsent distortion product otoacoustic emissions

MYO7A KCNQ1 CHD7

1.17e-0341713MP:0004737
MousePhenoabnormal cochlear labyrinth morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.22e-03235716MP:0004426
MousePhenoabnormal scala media morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.22e-03235716MP:0003169
MousePhenoincreased or absent threshold for auditory brainstem response

COCH MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.25e-03236716MP:0011967
MousePhenoabnormal neural crest cell physiology

HIF1A PKN2 CHD7

1.34e-0343713MP:0012745
MousePhenoabnormal hippocampus morphology

ATP6V0A1 FOLH1 POU3F3 SPG11 CHD7 LYST ABCB1

1.42e-03331717MP:0000807
MousePhenohead tilt

MYO6 MYO7A CHD7

1.43e-0344713MP:0005191
MousePhenoabnormal temporal lobe morphology

ATP6V0A1 FOLH1 POU3F3 SPG11 CHD7 LYST ABCB1

1.58e-03337717MP:0000801
MousePhenoabnormal cochlea morphology

FAT4 MYO6 MYO7A KCNQ1 POU3F4 CHD7

1.60e-03248716MP:0000031
MousePhenoabnormal bony labyrinth

POU3F4 CHD7

1.62e-0312712MP:0004289
MousePhenoabnormal orientation of inner hair cell stereociliary bundles

MYO6 MYO7A

1.62e-0312712MP:0004492
MousePhenofused inner hair cell stereocilia

MYO6 MYO7A

1.62e-0312712MP:0004533
MousePhenoabnormal vestibular saccule morphology

MYO6 MYO7A KCNQ1

1.63e-0346713MP:0006089
MousePhenoabnormal vestibular hair cell morphology

MYO6 MYO7A KCNQ1

1.84e-0348713MP:0002623
MousePhenoabnormal reflex

OARD1 ATP6V0A1 MYO6 MYO7A NUFIP2 SCN10A KCNQ1 POU3F4 SPG11 PKN2 BIN2 CHD7 CEP126 CSMD1 LYST

1.85e-0312947115MP:0001961
MousePhenovestibular saccular macula degeneration

MYO6 MYO7A

1.91e-0313712MP:0004331
MousePhenodecreased inner hair cell stereocilia number

MYO6 MYO7A

1.91e-0313712MP:0004534
DomainTF_POU_3

POU3F1 POU3F2 POU3F3 POU3F4

4.19e-104864IPR016362
DomainPOU

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865SM00352
DomainPOU_2

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865PS00465
DomainPOU_dom

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865IPR000327
DomainPOU_3

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865PS51179
DomainPou

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865PF00157
DomainPOU_1

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

7.72e-0916865PS00035
DomainPOU

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

1.09e-0817865IPR013847
DomainsrGAP2

SRGAP2C SRGAP2 SRGAP2B

9.43e-083863IPR030252
Domain-

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

1.37e-07278651.10.260.40
DomainLambda_DNA-bd_dom

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

2.00e-0729865IPR010982
DomainAnnexinVIII

ANXA8L1 ANXA8

2.10e-052862IPR009115
DomainIQ

PCP4 MYO6 MYO7A SCN10A ASPM

6.96e-0593865PS50096
DomainFCH

SRGAP2C SRGAP2 SRGAP2B

1.36e-0422863PF00611
DomainFCH

SRGAP2C SRGAP2 SRGAP2B

1.36e-0422863SM00055
DomainFCH_dom

SRGAP2C SRGAP2 SRGAP2B

1.56e-0423863IPR001060
DomainF_BAR

SRGAP2C SRGAP2 SRGAP2B

2.01e-0425863IPR031160
DomainF_BAR

SRGAP2C SRGAP2 SRGAP2B

2.01e-0425863PS51741
Domain-

PKN1 PKN2

2.08e-0458621.10.287.160
DomainHomeobox_CS

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

2.19e-04186866IPR017970
DomainBRK

CHD9 CHD7

3.11e-046862SM00592
DomainBRK_domain

CHD9 CHD7

3.11e-046862IPR006576
DomainBRK

CHD9 CHD7

3.11e-046862PF07533
DomainIQ

MYO6 MYO7A SCN10A ASPM

3.22e-0471864PF00612
DomainHr1

PKN1 PKN2

4.34e-047862SM00742
DomainHR1

PKN1 PKN2

5.76e-048862PF02185
DomainHomeobox

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

7.40e-04234866PF00046
DomainHOMEOBOX_1

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

7.73e-04236866PS00027
DomainHOX

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

7.91e-04237866SM00389
DomainIQ_motif_EF-hand-BS

MYO6 MYO7A SCN10A ASPM

7.92e-0490864IPR000048
DomainHOMEOBOX_2

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

8.26e-04239866PS50071
DomainHomeobox_dom

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

8.26e-04239866IPR001356
DomainKinase-like_dom

NEK3 MAPKAPK2 GUCY2D CHD9 PKN1 PKN2 MAP3K15 DYRK3 CDC7

8.64e-04542869IPR011009
DomainSer/Thr_kinase_AS

NEK3 MAPKAPK2 PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.30e-03357867IPR008271
DomainS_TKc

NEK3 MAPKAPK2 PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.34e-03359867SM00220
DomainPROTEIN_KINASE_ST

NEK3 MAPKAPK2 PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.40e-03362867PS00108
DomainANX

ANXA8L1 ANXA8

1.58e-0313862SM00335
DomainANNEXIN

ANXA8L1 ANXA8

1.58e-0313862PS00223
DomainAnnexin_repeat_CS

ANXA8L1 ANXA8

1.58e-0313862IPR018252
DomainAnnexin

ANXA8L1 ANXA8

1.58e-0313862PF00191
DomainAnnexin_repeat

ANXA8L1 ANXA8

1.58e-0313862IPR018502
Domain-

ANXA8L1 ANXA8

1.58e-03138621.10.220.10
DomainProtein_kinase_ATP_BS

NEK3 MAPKAPK2 PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.82e-03379867IPR017441
DomainAnnexin

ANXA8L1 ANXA8

1.84e-0314862IPR001464
DomainProt_kinase_dom

NEK3 MAPKAPK2 GUCY2D PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.85e-03489868IPR000719
DomainPkinase

NEK3 MAPKAPK2 PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.88e-03381867PF00069
DomainPROTEIN_KINASE_DOM

NEK3 MAPKAPK2 GUCY2D PKN1 PKN2 MAP3K15 DYRK3 CDC7

1.95e-03493868PS50011
Domain-

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

1.96e-032838661.10.10.60
DomainPyr_redox_2

DLD SQOR

3.41e-0319862PF07992
DomainHomeodomain-like

POU3F1 POU3F2 POU3F3 POU3F4 PBX2 POU2F3

4.31e-03332866IPR009057
DomainPAS_fold_3

HIF1A KCNH7

4.98e-0323862IPR013655
DomainPAS_3

HIF1A KCNH7

4.98e-0323862PF08447
Pubmed

Structure and evolution of four POU domain genes expressed in mouse brain.

POU3F1 POU3F2 POU3F3 POU3F4

3.83e-1148841565620
Pubmed

The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

POU3F1 POU3F2 POU3F3 POU3F4

1.91e-1058849105675
Pubmed

Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.

POU3F1 POU3F2 POU3F3 POU3F4

4.77e-09988415872005
Pubmed

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

SRGAP2C SRGAP2 SRGAP2B

1.57e-08388322559944
Pubmed

Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.

POU3F2 POU3F3 POU3F4

1.57e-0838838703082
Pubmed

Murine chromosomal location of four class III POU transcription factors.

POU3F1 POU3F2 POU3F3 POU3F4

1.86e-08128848276397
Pubmed

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.

POU3F1 POU3F2 POU3F3 POU3F4

2.69e-08138848543156
Pubmed

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.

POU3F1 POU3F2 POU3F3 POU3F4

3.76e-081488417141158
Pubmed

Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.

SRGAP2C SRGAP2 SRGAP2B

6.25e-08488322559943
Pubmed

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

POU3F1 POU3F2 POU3F3

6.25e-08488326265007
Pubmed

The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.

POU3F1 POU3F2 POU3F3 POU3F4

6.80e-08168849118797
Pubmed

Cooperative function of POU proteins and SOX proteins in glial cells.

POU3F1 POU3F2 POU3F3

1.56e-0758839632656
Pubmed

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.

POU3F2 POU3F3 POU3F4 SORL1

1.80e-072088412130536
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

MFAP1 FAT4 NEK3 NUFIP2 PKN1 RPL22L1 AGPS PLCH1

2.21e-0724688815345747
Pubmed

Expression of a large family of POU-domain regulatory genes in mammalian brain development.

POU3F1 POU3F2 POU3F3

3.11e-0768832739723
Pubmed

Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.

POU3F1 POU3F2 POU3F3

5.44e-07788317301088
Pubmed

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

POU3F1 POU3F2 POU3F3 POU3F4

5.48e-072688422992956
Pubmed

Chromosomal organization of mammalian POU domain factors.

POU3F2 POU3F3 POU3F4

1.30e-0698838276396
Pubmed

Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset.

MYO6 KCNQ1 POU3F4

3.39e-061288337720106
Pubmed

Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.

MYO7A POU3F2 POU3F3

3.39e-061288319743445
Pubmed

TaqI polymorphisms at the annexin VIII locus (ANX8).

ANXA8L1 ANXA8

6.33e-0628821364010
Pubmed

BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2.

POU3F2 POU3F4

6.33e-06288231371344
Pubmed

Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.

ANXA8L1 ANXA8

6.33e-06288229306076
Pubmed

[Effect of fractioned irradiation on HIF-1alpha and MDR1 expression in esophageal cancer cells].

HIF1A ABCB1

6.33e-06288220501388
Pubmed

Involvement of hypoxia-inducible factor-1 alpha in the upregulation of P-glycoprotein in refractory epilepsy.

HIF1A ABCB1

6.33e-06288231634239
Pubmed

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.

SRGAP2C SRGAP2

6.33e-06288227373832
Pubmed

Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.

ANXA8L1 ANXA8

6.33e-06288221344395
Pubmed

Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.

UBE2Q1 UBE2Q2

6.33e-06288226745068
Pubmed

Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.

ANXA8L1 ANXA8

6.33e-06288216203777
Pubmed

Annexins: from structure to function.

ANXA8L1 ANXA8

6.33e-06288211917092
Pubmed

Novel roles of PRK1 and PRK2 in cilia and cancer biology.

PKN1 PKN2

6.33e-06288232127582
Pubmed

LHBs can elevate the expression of MDR1 through HIF-1α in patients with CHB infection: a comparative proteomic study.

HIF1A ABCB1

6.33e-06288227999186
Pubmed

Expression of HIF-1α and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone.

HIF1A ABCB1

6.33e-06288224590840
Pubmed

Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.

ANXA8L1 ANXA8

6.33e-06288224769558
Pubmed

HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein.

HIF1A ABCB1

6.33e-06288224901645
Pubmed

Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.

POU3F1 POU3F3

6.33e-0628828663425
Pubmed

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.

HIF1A ABCB1

6.33e-06288220217131
Pubmed

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.

PKN1 PKN2

6.33e-06288226296974
Pubmed

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.

SRGAP2C SRGAP2B

6.33e-06288231822692
Pubmed

HIF-1α/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer.

HIF1A ABCB1

6.33e-06288226717965
Pubmed

Annexins: linking Ca2+ signalling to membrane dynamics.

ANXA8L1 ANXA8

6.33e-06288215928709
Pubmed

DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.

ERCC4 MAPKAPK2

6.33e-06288225019640
Pubmed

Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.

PKN1 PKN2

6.33e-0628827851406
Pubmed

Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.

POU3F1 POU3F3

6.33e-0628829457692
Pubmed

Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation.

POU3F2 CHD7

6.33e-06288215353999
Pubmed

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

ANXA8L1 ANXA8

6.33e-06288225803307
Pubmed

Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.

POU3F1 POU3F2 POU3F3

6.97e-061588318255031
Pubmed

Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.

POU3F1 POU3F2 POU3F3

8.56e-061688319527706
Pubmed

Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes.

COCH KCNQ1 POU3F4

1.04e-051788318353863
Pubmed

PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.

PCP4 POU3F1 POU3F2

1.47e-051988333597191
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

MFAP1 ATP6V0A1 MYO6 CPSF1 MCM7 SQOR ABCB1

1.52e-0531388738270169
Pubmed

Transcriptional regulation of cortical neuron migration by POU domain factors.

POU3F1 POU3F2 POU3F3

1.73e-052088311859196
Pubmed

A quantitative survey of gravity receptor function in mutant mouse strains.

MYO6 MYO7A POU3F4

1.73e-052088316235133
Pubmed

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

PKN1 PKN2

1.90e-05388217332740
Pubmed

Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.

PKN1 PKN2

1.90e-05388234499618
Pubmed

Specific expression of annexin A8 in adult murine stratified epithelia.

ANXA8L1 ANXA8

1.90e-05388217082908
Pubmed

Sodium channels and mammalian sensory mechanotransduction.

SCN10A SCNN1A

1.90e-05388222449024
Pubmed

Selected Genetic Polymorphisms Associated with Hypoxia and Multidrug Resistance in Monoclonal Gammopathies Patients.

HIF1A ABCB1

1.90e-05388230441975
Pubmed

PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.

PKN1 PKN2

1.90e-05388235730579
Pubmed

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.

PKN1 PKN2

1.90e-05388227569559
Pubmed

E-cadherin increasing multidrug resistance protein 1 via hypoxia-inducible factor-1α contributes to multicellular resistance in colorectal cancer.

HIF1A ABCB1

1.90e-05388226219897
Pubmed

Expression of MDR1, HIF-1α and MRP1 in sacral chordoma and chordoma cell line CM-319.

HIF1A ABCB1

1.90e-05388221143841
Pubmed

The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.

POU3F2 POU3F3

1.90e-05388216547000
Pubmed

Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.

ANXA8L1 ANXA8

1.90e-0538822530088
Pubmed

Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α.

HIF1A ABCB1

1.90e-05388227604859
Pubmed

K+ channels regulate ENaC expression via changes in promoter activity and control fluid clearance in alveolar epithelial cells.

SCNN1A KCNQ1

1.90e-05388222406554
Pubmed

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.

SCN10A KCNQ1

1.90e-05388226971948
Pubmed

Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.

PKN1 PKN2

1.90e-0538829446575
Pubmed

Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.

PKN1 PKN2

1.90e-05388221754995
Pubmed

Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.

POU3F1 POU2F3

1.90e-05388217195013
Pubmed

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease.

HIF1A ABCB1

1.90e-05388230098863
Pubmed

Secreted phosphoprotein 1 promotes angiogenesis of glioblastoma through upregulating PSMA expression via transcription factor HIF1α.

HIF1A FOLH1

1.90e-05388236305723
Pubmed

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.

PKN1 PKN2

1.90e-05388227919031
Pubmed

A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.

SCNN1A KCNQ1 POU2F3

2.01e-052188337045597
Pubmed

Genetic Hearing Loss Overview

COCH MYO6 MYO7A POU3F4

3.09e-057088420301607
Pubmed

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.

ASPM POU3F2 POU3F3

3.46e-052588339271675
Pubmed

Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.

POU3F2 POU3F3

3.79e-05488226951672
Pubmed

Identification of multiple, novel, protein kinase C-related gene products.

PKN1 PKN2

3.79e-0548827988719
Pubmed

A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells.

POU3F1 POU3F2

3.79e-05488215893976
Pubmed

Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia.

MYO6 MYO7A

3.79e-05488212966030
Pubmed

MCM2-7-dependent cohesin loading during S phase promotes sister-chromatid cohesion.

MCM7 CDC7

3.79e-05488229611806
Pubmed

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.

PKN1 PKN2

3.79e-05488210753910
Pubmed

A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis.

MYO6 MYO7A

3.79e-05488215657400
Pubmed

Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.

POU3F1 POU3F2

3.79e-05488222566684
Pubmed

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.

PKN1 PKN2

3.79e-05488225513777
Pubmed

Vertebrate unconventional myosins.

MYO6 MYO7A

3.79e-0548828690736
Pubmed

A central to peripheral progression of cell cycle exit and hair cell differentiation in the developing mouse cristae.

MYO6 MYO7A

3.79e-05488226826497
Pubmed

Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families.

MYO7A POU3F4

3.79e-05488233976695
Pubmed

In-depth genetic and molecular characterization of diaphanous related formin 2 (DIAPH2) and its role in the inner ear.

MYO6 MYO7A

3.79e-05488236689403
Pubmed

Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.

PKN1 PKN2

3.79e-05488231564129
Pubmed

Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.

PKN1 PKN2

3.79e-05488223223530
Pubmed

Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.

POU3F1 POU2F3

3.79e-0548829242494
Pubmed

Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse.

COCH MYO7A POU3F4

4.90e-052888320346939
Pubmed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

POU3F1 POU3F2 POU3F3 SORL1

5.76e-058288431073041
Pubmed

The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.

POU3F1 POU2F3

6.30e-05588223341029
Pubmed

Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

PKN1 PKN2

6.30e-05588220188095
Pubmed

Genetics of vestibular disorders: pathophysiological insights.

COCH MYO7A

6.30e-05588227083884
Pubmed

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.

PKN1 PKN2

6.30e-05588210764742
Pubmed

Tracing Sox10-expressing cells elucidates the dynamic development of the mouse inner ear.

MYO6 MYO7A

6.30e-05588223684581
Pubmed

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication.

HIF1A MCM7

6.30e-05588223405012
InteractionPOU3F4 interactions

POU3F1 POU3F2 POU3F3 POU3F4

4.39e-096854int:POU3F4
InteractionPOU3F3 interactions

POU3F1 POU3F2 POU3F3 POU3F4 ANXA8

2.95e-0822855int:POU3F3
InteractionPOU3F1 interactions

POU3F1 POU3F2 POU3F3 POU3F4

1.09e-0619854int:POU3F1
InteractionPOU3F2 interactions

POU3F1 POU3F2 POU3F3 POU3F4

1.36e-0620854int:POU3F2
InteractionANXA8 interactions

PCP4 ANXA8L1 POU3F3 ANXA8

4.98e-0548854int:ANXA8
Cytoband10q11.22

FRMPD2 ANXA8L1 ANXA8 FRMPD2B

1.21e-064188410q11.22
CytobandEnsembl 112 genes in cytogenetic band chr10q11

FRMPD2 ANXA8L1 ANXA8 FRMPD2B

4.86e-04188884chr10q11
GeneFamilyPOU class homeoboxes and pseudogenes

POU3F1 POU3F2 POU3F3 POU3F4 POU2F3

8.39e-0923575523
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP2C SRGAP2 SRGAP2B

5.03e-05235731288
GeneFamilyC2 domain containing protein kinases

PKN1 PKN2

4.32e-0410572835
GeneFamilyActins|Deafness associated genes

COCH MYO6 MYO7A POU3F4

4.43e-041135741152
GeneFamilyAnnexins|Endogenous ligands

ANXA8L1 ANXA8

7.45e-0413572404
GeneFamilyPotassium voltage-gated channels

KCNH7 KCNQ1

7.05e-0340572274
GeneFamilyUbiquitin conjugating enzymes E2

UBE2Q1 UBE2Q2

7.40e-0341572102
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION_HBZ

POU3F2 POU3F3 MCM7 POU2F3

7.20e-0637884M802
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION_HBZ

POU3F2 POU3F3 MCM7 POU2F3

7.20e-0637884MM509
CoexpressionNIKOLSKY_BREAST_CANCER_1Q32_AMPLICON

MAPKAPK2 SRGAP2 DYRK3

1.02e-0513883M1207
CoexpressionMCCABE_BOUND_BY_HOXC6

PCP4 ERCC4 COCH ACTR10 FRMPD2 WNT9B CHD9 FRMPD2B MAP3K15

2.49e-05461889M6376
CoexpressionGSE40274_IRF4_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

CEBPZ WNT9B SCNN1A SQOR OGN

4.94e-05118885M9155
CoexpressionGSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_DN

MYO6 PKN2 RPL22L1 CPT2 SQOR OGN

5.90e-05200886M6313
CoexpressionGSE15330_WT_VS_IKAROS_KO_HSC_UP

HIF1A ACTR10 SPG11 CHD7 SQOR ABCB1

5.90e-05200886M7040
ToppCellControl-Myeloid-cDC2|World / Disease state, Lineage and Cell class

SRGAP2C HIF1A PLXNC1 SRGAP2 SRGAP2B CSMD1

2.20e-0619188611dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

HIF1A PLXNC1 BIN2 USP15 LYST SORL1

2.63e-061978861acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellILEUM-non-inflamed-(2)_B_cell-(2)_Naive_B_cells|(2)_B_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

HIF1A ATP6V0A1 LYST ABCB1 SORL1

1.80e-051638859add806d706f7170a49b2c2dcc14343e9befd26c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SRGAP2C BIN2 SRGAP2 SRGAP2B SORL1

2.03e-05167885942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KCNH7 POU3F1 NLGN1 DYRK3 SORL1

2.54e-05175885ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KCNH7 POU3F1 NLGN1 DYRK3 SORL1

2.54e-0517588521f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCP4 RAP1GAP POU3F1 NLGN1 CSMD1

2.90e-05180885fa819df81fca95c2cc602fede635cb03e3f35fad
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCP4 RAP1GAP POU3F1 NLGN1 CSMD1

2.90e-05180885907cd510fd2e21532ce04ba687e8894f7af71f27
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP KCNH7 SCNN1A KCNQ1 POU3F3

3.06e-051828852ef6889321fd0104d277518d130e19143b3af41c
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRACD PLXNC1 POU3F1 POU3F4 CSMD1

3.31e-0518588511c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCP4 NRG2 KCNQ1 CSMD1 POU2F3

3.31e-05185885686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellCOPD-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

HIF1A ANXA8L1 ANXA8 NLGN1 OGN

3.57e-05188885159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCellControl-Myeloid-cDC2|Control / Disease state, Lineage and Cell class

SRGAP2C PLXNC1 SRGAP2 SRGAP2B CSMD1

3.76e-051908854e481e42353d47af7991744000403af2873f6a41
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

HIF1A PLXNC1 USP15 LYST SORL1

3.95e-051928850b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGEF39 ASPM MCM7 BIN2 CDC7

4.15e-051948856cc689595a182fbf685fa2f3b9c300f7170fb81f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIF1A ATP6V0A1 PLXNC1 USP15 LYST

4.15e-05194885dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLXNC1 BIN2 SRGAP2 SRGAP2B LYST

4.25e-051958851d58585557bf8e9ce4d514e128d3a902b526331d
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SRGAP2C HIF1A PLXNC1 SRGAP2 SRGAP2B

4.25e-051958852f2e29089a8cb748d2c1329c5c8465165b25bc8b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SRGAP2C HIF1A PLXNC1 SRGAP2 SRGAP2B

4.25e-05195885c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO6 SCNN1A KCNQ1 NLGN1 SORL1

4.36e-05196885c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SRGAP2C HIF1A SRGAP2 SRGAP2B CSMD1

4.46e-05197885a902aa05e5f711bcfdd9e19749ab636b597eb116
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-05200885a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-05200885dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-052008853bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-0520088521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellKidney-Tubules|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

RAP1GAP SCNN1A KCNQ1 POU3F3 SORL1

4.79e-052008850726456906e078244a9cff35aee8c5bce4566fb1
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-05200885a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2C PKN2 SRGAP2 SRGAP2B SORL1

4.79e-0520088533036d21c1c82109284473a515c4f890b33fdd5c
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

POU3F1 NLGN1 DYRK3 SORL1

1.85e-041438845fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCellControl-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

HIF1A MAPKAPK2 NLGN1 SQOR

2.01e-04146884fcd8548b42275758d7d77ad2651afe7ad0e5ea2a
ToppCell356C-Lymphocytic-ILC-ILC-2|356C / Donor, Lineage, Cell class and subclass (all cells)

MYO7A TOR1B TRAV25 DYRK3

2.52e-041558840fd66c623cb433ceaa893bc21ba2e3b394faaf70
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A PBX2 LYST SORL1

2.71e-04158884d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A PBX2 LYST SORL1

2.71e-04158884ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PCP4 USP26 HIF1A SRGAP2

2.78e-0415988431ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DLD BUD13 AGPS POU2F3

2.78e-04159884ba82d1f55dd77c4b2183981b76cab1480fba75ad
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRG2 KCNQ1 PLCH1 POU2F3

2.92e-04161884f5df8c6a340d5026726804b103e32137f363ca40
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COCH SCNN1A POU3F1 POU3F2

3.06e-041638841e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COCH SCNN1A POU3F1 POU3F2

3.06e-04163884431221a41d396b09170476179590eaf8a55266d8
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCP4 RAP1GAP POU3F3 FRMPD2B

3.06e-04163884cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU3F2 MCM7 BIN2 ABCB1

3.20e-041658845f606959a060b1ae241217889560c6761ac73bbb
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

ANXA8L1 ANXA8 NLGN1 OGN

3.27e-041668841ed3788257e14f097862b999f020bfe2a57de52b
ToppCelldroplet-Lung-LUNG-1m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNC1 MCM7 MAP3K15 CDC7

3.35e-04167884e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAAF8 FAT4 POU3F1 PABPC5

3.35e-04167884b742558ca92985db0a67c88f530bc375f3d3bb98
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A SQOR LYST SORL1

3.50e-04169884a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PARP2 ANXA8L1 SPG11 UBE2Q2

3.50e-04169884665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCP4 NRG2 CSMD1 POU2F3

3.50e-0416988405e12524d68d409fed386ffad233305683b4575b
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A SQOR LYST SORL1

3.50e-04169884e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A SQOR LYST SORL1

3.50e-041698842341eddfedaad8cee779c37bb87f7def058588ca
ToppCellfacs-Marrow-Granulocytes-18m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A SQOR LYST SORL1

3.50e-0416988494871936ccfc73b56d425373b989b87c059d4493
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PARP2 ANXA8L1 SPG11 UBE2Q2

3.50e-041698846614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAAF8 RAP1GAP SCNN1A POU3F1

3.66e-0417188448125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCP4 KCNH7 FRMPD2 FRMPD2B

3.66e-041718849e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCell356C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MYO7A TOR1B TRAV25 DYRK3

3.66e-041718843d26ef58fe5231373d7df9ac79d225546918cf82
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCP4 FRMPD2 FRMPD2B PLCH1

3.66e-041718846a489a75eeab2a2d48d604682e93599c20a945fe
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NEK3 NRG2 POU3F1 ANXA8

3.75e-04172884bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAAF8 NRG2 ABCB1 SORL1

3.75e-041728846379ae0aca9007c3a8a87e3330908fc90961ad3f
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NEK3 NRG2 POU3F1 ANXA8

3.75e-04172884aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

3.75e-04172884381ae1c3c07d0a424f43455ec571653b192a946a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CRACD SCN10A NLGN1 PLCH1

3.83e-041738842e35bf2b5534a289d93a09faae660f665c131062
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCP4 KCNH7 FRMPD2 FRMPD2B

3.83e-041738845aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF39 PARP2 ASPM POU3F4

3.83e-04173884506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRACD KCNH7 ASPM POU3F4

3.83e-04173884f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A FDFT1 SCNN1A ANXA8

3.91e-04174884d927504d27b07bbc580bf57c60b383bd28624652
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

3.91e-04174884dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CRACD SRGAP2C SRGAP2 SRGAP2B

4.00e-04175884a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FDFT1 SCNN1A PLCH1 UBE2Q2

4.00e-04175884dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN10A ANXA8 POU2F3 ABCB1

4.08e-041768848e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN10A ANXA8 POU2F3 ABCB1

4.08e-04176884ed575330a08a6748ea4b28433292c8cfd157d444
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUFIP2 CHD9 PKN2 LYST

4.08e-04176884749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|normal_Lung / Location, Cell class and cell subclass

PCP4 ANXA8L1 ANXA8 OGN

4.08e-04176884f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCellfacs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7A ARHGEF39 ASPM DYRK3

4.17e-041778848a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNH7 POU3F3 MAP3K15 SORL1

4.17e-04177884dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.17e-041778844d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellfacs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7A ARHGEF39 ASPM DYRK3

4.17e-04177884e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCellLPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HIF1A DLD BIN2 PLCH1

4.17e-041778842dd6dd5193bda9ba1c6b299ec47890fdc92f88b1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANXA8L1 ANXA8 NLGN1 OGN

4.17e-041778840912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCP4 NRG2 KCNQ1 POU2F3

4.26e-04178884f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.26e-04178884edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP POU3F1 MCM7 CSMD1

4.26e-04178884ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.35e-041798847394e77e665bf16d3733df91bb12907be460ab44
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCP4 KCNH7 CSMD1 ABCB1

4.35e-04179884228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCP4 KCNH7 POU3F3 ABCB1

4.35e-04179884b8ca29aebd25ebac441bebd769bbf98c536d3166
ToppCellIPF-Epithelial-Mesothelial|IPF / Disease state, Lineage and Cell class

ANXA8L1 ANXA8 NLGN1 OGN

4.45e-041808841fa54bf4dba72866b2295639d991af639341bc08
ToppCelldroplet-Liver-LIVER-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN10A ANXA8 OGN POU2F3

4.45e-041808843d95232b5785c705f41e01e3ffe0fa8dce1ff0a7
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP SCNN1A POU3F3 SORL1

4.45e-041808840b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCelldroplet-Liver-LIVER-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN10A ANXA8 OGN POU2F3

4.45e-0418088447e345359064dc8ceec982b062e47802e728b43f
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LIPT1 CHD9 POU3F3 CDC7

4.45e-04180884e9785ac2806103f725f5a5208495826354ec6e22
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCP4 POU3F2 FRMPD2B PLCH1

4.45e-04180884a407376209d80177bf7fc4200219030c83cb5f14
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.54e-041818845bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellCOPD-Myeloid-DC_Mature|World / Disease state, Lineage and Cell class

SRGAP2C NRG2 SRGAP2 SRGAP2B

4.54e-04181884675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2|TCGA-Skin / Sample_Type by Project: Shred V9

CRACD PLXNC1 LYST DYRK3

4.54e-041818849d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPM POU3F3 MCM7 CHD7

4.54e-04181884f2ebeb4941510c4b6e50f2379c574d1778d6ced1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.54e-041818848e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP KCNH7 SCNN1A KCNQ1

4.63e-0418288475608f80fd570da499891dc02f8649d5428b896c
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP SCNN1A KCNQ1 POU3F3

4.63e-04182884fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP POU3F1 POU3F2 CSMD1

4.63e-0418288482ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAP1GAP BUD13 POU3F1 NLGN1

4.63e-04182884c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

CRACD SRGAP2C SRGAP2 SRGAP2B

4.73e-04183884fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CRACD SRGAP2C SRGAP2 SRGAP2B

4.73e-041838843c516fe5083f02bad1f464ed284010b4131a833c
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU3F1 POU3F2 POU3F4 CSMD1

4.73e-041838842cf36ad89584eb9f8b04de52a1b511b7f3527884
Drugvinylidene chloride

NEK3 RAP1GAP ATP6V0A1 MYO7A ACTR10 ASPM SCNN1A MTTP KCNQ1 DLD POU3F3 RPL22L1 CEP126 AGPS PLCH1 CPT2 LYST DYRK3 CDC7

1.96e-0614758619ctd:C029297
DiseaseHereditary hearing loss and deafness

COCH MYO6 MYO7A KCNQ1 DLD POU3F4

4.49e-06146866cv:C0236038
DiseaseNonsyndromic genetic hearing loss

COCH MYO6 MYO7A POU3F4

7.35e-0576864cv:C5680182
DiseaseAutosomal dominant nonsyndromic hearing loss

COCH MYO6 MYO7A

8.27e-0529863cv:C5779548
DiseaseNonsyndromic Deafness

COCH MYO6 MYO7A POU3F4

9.43e-0581864C3711374
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD9 CHD7

1.75e-047862DOID:0050834 (implicated_via_orthology)
Diseasehearing impairment

COCH MYO7A POU3F4 CHD7

1.97e-0498864C1384666
DiseaseHypermetropia, Myopia

ERCC4 FRMPD2 CHD7 FRMPD2B PLCH1

2.34e-04189865HP_0000540, HP_0000545
DiseaseCannabis Abuse

FDFT1 ABCB1

3.72e-0410862C0006868
DiseaseCannabis-Related Disorder

FDFT1 ABCB1

3.72e-0410862C0236735
Diseasepancreatic hormone measurement

FRMPD2 FRMPD2B

3.72e-0410862EFO_0020621
Diseasemean arterial pressure, response to high sodium diet

KCNQ1 CSMD1

3.72e-0410862EFO_0005401, EFO_0006340
DiseaseHashish Abuse

FDFT1 ABCB1

3.72e-0410862C0018614
Diseaselong QT syndrome (implicated_via_orthology)

KCNH7 KCNQ1

3.72e-0410862DOID:2843 (implicated_via_orthology)
Diseaseheart rate

SRGAP2C ERCC4 CSMD1 UBE2Q2 SORL1

5.20e-04225865EFO_0004326
DiseasePeripheral Nervous System Diseases

ERCC4 LYST ABCB1

5.33e-0454863C4721453
DiseaseMetastatic melanoma

GUCY2D PKN1 MAP3K15

5.33e-0454863C0278883
DiseaseT wave morphology measurement

SCN10A KCNQ1

7.47e-0414862EFO_0008398
Diseaseamino acid measurement

FAT4 NEK3 FOLH1 BUD13 POU3F2 PKN1 NLGN1 CSMD1

8.19e-04678868EFO_0005134
DiseaseGerm Cell Cancer

ERCC4 SCNN1A

8.60e-0415862C0740345
DiseaseEmbryonal Neoplasm

ERCC4 SCNN1A

8.60e-0415862C0027654
DiseaseNeoplasms, Germ Cell and Embryonal

ERCC4 SCNN1A

8.60e-0415862C0027658
DiseaseGerm cell tumor

ERCC4 SCNN1A

8.60e-0415862C0205851
DiseaseNeoplasms, Embryonal and Mixed

ERCC4 SCNN1A

8.60e-0415862C0205852
Diseasehepatic encephalopathy (biomarker_via_orthology)

HIF1A ABCB1

8.60e-0415862DOID:13413 (biomarker_via_orthology)
DiseaseCancer, Embryonal

ERCC4 SCNN1A

8.60e-0415862C0751364
DiseaseCancer, Embryonal and Mixed

ERCC4 SCNN1A

8.60e-0415862C0751365
Diseaseglucose measurement

ABITRAM FOLH1 NUFIP2 KCNQ1 MAP3K15 RPL22L1

8.67e-04380866EFO_0004468
DiseaseRomano-Ward Syndrome

SCN10A KCNQ1

9.81e-0416862C0035828
DiseaseCannabis Dependence

FDFT1 ABCB1

1.11e-0317862C0006870
Diseasetriacylglycerol 56:3 measurement

MAP3K15 NLGN1

1.25e-0318862EFO_0010430
DiseaseDisease Exacerbation

HIF1A RAP1GAP CPSF1 ABCB1

1.40e-03165864C0235874
Diseaseserum homoarginine measurement

RAP1GAP KCNQ1

1.54e-0320862EFO_0005421
Diseaseresponse to bronchodilator, FEV/FEC ratio

KCNH7 ERCC4 MYO7A BUD13 POU3F2 PKN1 CEP126 LYST

1.78e-03766868EFO_0004713, GO_0097366
DiseaseHeadache, type 2 diabetes mellitus

KCNQ1 NLGN1

2.04e-0323862HP_0002315, MONDO_0005148
Diseasecerebellum cortex volume change measurement, age at assessment

CSMD1 PLCH1

2.61e-0326862EFO_0008007, EFO_0021497
DiseaseMicronuclei, Chromosome-Defective

HIF1A ERCC4

2.61e-0326862C1449861
DiseaseMicronuclei, Genotoxicant-Induced

HIF1A ERCC4

2.61e-0326862C1449862
Diseaserefractive error

GUCY2D FRMPD2 CHD7 FRMPD2B AGPS

2.68e-03326865MONDO_0004892

Protein segments in the cluster

PeptideGeneStartEntry
KKGQTVFKGASRRQQ

USP26

611

Q9BXU7
NGFEQKRFARLASKK

BUD13

591

Q9BRD0
RRKGFNAQFQVKKAI

CSMD1

301

Q96PZ7
LIFGNSRKKGFQINK

FAT4

3336

Q6V0I7
SRKKGFQINKKTGQI

FAT4

3341

Q6V0I7
RLQNKVSGKFKRGAQ

ABITRAM

76

Q9NX38
GLFAKQVQKKFSRAQ

BIN2

11

Q9UBW5
IKRFKAKQGQNKFLS

CHD7

856

Q9P2D1
IQARSKGFIQKRKFQ

ASPM

2916

Q8IZT6
KGFIQKRKFQEIKNS

ASPM

2921

Q8IZT6
KRGLKIQAAKFNIDG

ACTR10

221

Q9NZ32
KAGFARQGAKEKQLL

ABHD8

311

Q96I13
TLQEQLKKNKGFRRF

ARHGEF39

116

Q8N4T4
VQFQRGGKEFLKKQK

CPT2

446

P23786
SGNLNKAKEIFQKKF

PARP2

166

Q9UGN5
DRNGGAKKKNFFKLN

ABCB1

6

P08183
RQQIAKSFKAQFGKD

ANXA8

56

P13928
ARFKNGKQIRKNEQF

ANKRD31

451

Q8N7Z5
KFGGVQELLNQQKKS

OARD1

51

Q9Y530
KALLKLKNGSVFAQG

OR10G7

296

Q8NGN6
GNKRIRYKKNIGKFQ

PBX2

296

P40425
ILGSGFALKVQQKQR

KCNQ1

346

P51787
AQNTKFFKQKAAGVR

MFAP1

411

P55081
GKVLQIFNKRTQEKF

MAPKAPK2

76

P49137
TFDLFKNINKGRKTN

GUCY2D

801

Q02846
GTIIRKFEGQNKKFI

KCNH7

16

Q9NS40
KFEGQNKKFIIANAR

KCNH7

21

Q9NS40
KKGKEQNTQRSFFLR

HIF1A

156

Q16665
AAGFKKTVKNGLILQ

LIPT1

21

Q9Y234
GKVFRGNKVKNAQLA

FOLH1

206

Q04609
NQQVFKGAVKIRKGQ

FDFT1

306

P37268
SQLGQGNLKVRFKKV

CPSF1

881

Q10570
IQSQFRKFQKKKAGS

PCP4

46

P48539
GQAKEKIFQAFLSKN

PLXNC1

1231

O60486
NVNQQRGEKSIFKGK

MTTP

91

P55157
KYGNGRKNSRLQFNK

NRG2

286

O14511
EQFAKQFKQRRIKLG

POU3F1

256

Q03052
SRGIKANAFKKLNNL

OGN

201

P20774
ATNFGKIRGIKKELN

NLGN1

56

Q8N2Q7
KTFKQRRIKLGFTQG

POU2F3

196

Q9UKI9
KNIFLTQNGKVKLGD

NEK3

131

P51956
LGKKQFKYGNQLVRL

MCM7

26

P33993
QFAKQFKQRRIKLGF

POU3F4

196

P49335
FFADKKNKRRNFGQI

OR1L1

16

Q8NH94
RKSGVGNIFIKNLDK

PABPC5

101

Q96DU9
KLTFQKQGLAQKRPF

CHD9

2356

Q3L8U1
RQQIAKSFKAQFGKD

ANXA8L1

56

Q5VT79
GSLKKNEQNFKLAGV

CDC7

26

O00311
KALIINQSFKFGNQK

CEP126

591

Q9P2H0
VKLKKNANGLGFSFV

FRMPD2B

91

Q6IN97
KLKKNANGLGFSFVQ

FRMPD2

1081

Q68DX3
VKTLQQQLGKNIKFG

CRACD

36

Q6ZU35
GLARFTNAKSKFQKG

CENPJ

381

Q9HC77
GKSQLLQQLRAFQKG

DNAAF8

431

Q8IYS4
FQRILQKQGFKFKLN

DLD

261

P09622
QKQGFKFKLNTKVTG

DLD

266

P09622
QKDKFLKNRGFSLLA

LYST

2366

Q99698
IGQRRFNLQKNFVGK

COCH

176

O43405
NKRNGVAKVNIFFKE

SCNN1A

516

P37088
AKQFKQRRIKLGFTQ

POU3F3

326

P20264
KNKFQGFSVQLVRKF

DYRK3

301

O43781
FAGSFQGPRKKKRNL

CEBPZ

956

Q03701
GFLRQVNKGKKNRIA

MAP3K15

906

Q6ZN16
FRKTGKRSKANIIFN

SQOR

216

Q9Y6N5
KKISDKLNFGLGNRS

SORL1

146

Q92673
TINGKFQLSGQKLFI

PSG6

366

Q00889
LIFGAQNRFRLNKKK

CDC40

486

O60508
FLGQKVKLQDFKGFR

RAP1GAP

226

P47736
EGQGFAFRRKLKIQQ

CCDC59

51

Q9P031
GRLFKKSKEVGQQLQ

SRGAP2C

136

P0DJJ0
GRLFKKSKEVGQQLQ

SRGAP2B

136

P0DMP2
KKIFSKQQGKAFQRA

PKN1

491

Q16512
RQKKIFSKQQGKTFL

PKN2

491

Q16513
EQFAKQFKQRRIKLG

POU3F2

271

P20265
SKFIFNKKGQIELTG

AGPS

101

O00116
QKSKTLIRGFQLFFK

SPG11

1531

Q96JI7
VKGKARVQFGANKNQ

UBE2Q2

331

Q8WVN8
QFLREKVKVNGKTGN

RPL22L1

36

Q6P5R6
ANTFGKAGIKTKNFI

NUFIP2

141

Q7Z417
SNNQIIKGKQKLGFL

THAP9

561

Q9H5L6
ALVGLQLFKGNLKNK

SCN10A

261

Q9Y5Y9
GRLFKKSKEVGQQLQ

SRGAP2

136

O75044
KGQLTGHKKRLFTFQ

USP15

701

Q9Y4E8
KNRQLQGLKGLFNKN

PLCH1

881

Q4KWH8
IIFFQGDQLKNRVKK

ATP6V0A1

221

Q93050
NKCGKTFGQKSNLRI

ZNF510

631

Q9Y2H8
QKRLTFQFGEAKKNS

TRAV25

76

A0A0B4J276
LFRQKNKRGFIKAFT

ERCC4

151

Q92889
KFLSNFLGSKRGNKD

WNT9B

171

O14905
IFKALTGFRNNKNPK

TOR1B

86

O14657
TLVKGKARVQFGANK

UBE2Q1

376

Q7Z7E8
GKLSFISVGNKFKTQ

MYO6

636

Q9UM54
RGFKDRSNFLKLKNA

MYO7A

756

Q13402