Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol	CACNA1C CACNA1S SLC8A1 CHD7 F2	1.13e-04	146	67	5	GO:0051209
GeneOntologyBiologicalProcess	sensory organ development	CACNA1C CACNA1S DDR1 INTU RIPOR2 BCL11B RP1L1 CHD7 PRDM16 ZNF513	1.16e-04	730	67	10	GO:0007423
GeneOntologyBiologicalProcess	negative regulation of sequestering of calcium ion	CACNA1C CACNA1S SLC8A1 CHD7 F2	1.16e-04	147	67	5	GO:0051283
GeneOntologyBiologicalProcess	filopodium assembly	RIPOR2 NRXN1 FGD5 AGRN	1.21e-04	78	67	4	GO:0046847
GeneOntologyBiologicalProcess	regulation of sequestering of calcium ion	CACNA1C CACNA1S SLC8A1 CHD7 F2	1.24e-04	149	67	5	GO:0051282
GeneOntologyBiologicalProcess	sequestering of calcium ion	CACNA1C CACNA1S SLC8A1 CHD7 F2	1.40e-04	153	67	5	GO:0051208
GeneOntologyBiologicalProcess	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	CACNA1C SLC8A1 CHD7	1.67e-04	33	67	3	GO:0010880
MousePheno	neonatal lethality, complete penetrance	CACNA1C TCF7L2 BCL11B IGF2R GPC3 LBX1 CTCF F2 PRDM16 AGRN PROC	1.21e-05	534	59	11	MP:0011087
MousePheno	perinatal lethality, complete penetrance	CACNA1C CACNA1S TCF7L2 BCL11B IGF2R GPC3 LBX1 CTCF F2 PRDM16 AGRN PROC	3.42e-05	712	59	12	MP:0011089
Domain	VDCC_L_a1su	CACNA1C CACNA1S	7.57e-05	4	67	2	IPR005446
Domain	EGF	NRXN1 AGRN F12 NOTCH3 PROC	8.92e-05	126	67	5	PF00008
Domain	ZnF_C2H2	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 ZFTA TUT1 PRDM16 ZNF513	1.30e-04	808	67	11	SM00355
Domain	Kringle-like	IGF2R F2 F12	2.03e-04	32	67	3	IPR013806
Domain	VDCC_a1su_IQ	CACNA1C CACNA1S	2.63e-04	7	67	2	IPR014873
Domain	GPHH	CACNA1C CACNA1S	2.63e-04	7	67	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1S	2.63e-04	7	67	2	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1S	2.63e-04	7	67	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1S	2.63e-04	7	67	2	PF08763
Domain	TRYPSIN_SER	TMPRSS15 F2 F12 PROC	3.06e-04	90	67	4	IPR033116
Domain	TRYPSIN_HIS	TMPRSS15 F2 F12 PROC	5.12e-04	103	67	4	IPR018114
Domain	Znf_C2H2-like	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 ZFTA PRDM16 ZNF513	5.12e-04	796	67	10	IPR015880
Domain	Znf_C2H2	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 TUT1 PRDM16 ZNF513	5.59e-04	805	67	10	IPR007087
Domain	VDCCAlpha1	CACNA1C CACNA1S	5.60e-04	10	67	2	IPR002077
Domain	TRYPSIN_SER	TMPRSS15 F2 F12 PROC	5.71e-04	106	67	4	PS00135
Domain	TRYPSIN_HIS	TMPRSS15 F2 F12 PROC	5.91e-04	107	67	4	PS00134
Domain	Tyr_kinase_rcpt_2_CS	DDR1 LTK	6.83e-04	11	67	2	IPR002011
Domain	-	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	6.83e-04	679	67	9	3.30.160.60
Domain	Peptidase_S1A	TMPRSS15 F2 F12 PROC	7.26e-04	113	67	4	IPR001314
Domain	TRYPSIN_DOM	TMPRSS15 F2 F12 PROC	7.75e-04	115	67	4	PS50240
Domain	zf-C2H2	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	7.90e-04	693	67	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	7.98e-04	694	67	9	IPR013087
Domain	RECEPTOR_TYR_KIN_II	DDR1 LTK	8.18e-04	12	67	2	PS00239
Domain	-	F2 PROC	8.18e-04	12	67	2	4.10.740.10
Domain	Coagulation_fac_subgr_Gla_dom	F2 PROC	8.18e-04	12	67	2	IPR017857
Domain	Tryp_SPc	TMPRSS15 F2 F12 PROC	8.27e-04	117	67	4	SM00020
Domain	Trypsin	TMPRSS15 F2 F12 PROC	9.38e-04	121	67	4	PF00089
Domain	Trypsin_dom	TMPRSS15 F2 F12 PROC	9.38e-04	121	67	4	IPR001254
Domain	-	IGF2R F12	9.64e-04	13	67	2	2.10.10.10
Domain	EGF_CA	AGRN F12 NOTCH3 PROC	9.67e-04	122	67	4	SM00179
Domain	Peptidase_S1_PA	TMPRSS15 F2 F12 PROC	9.97e-04	123	67	4	IPR009003
Domain	EGF-like_Ca-bd_dom	AGRN F12 NOTCH3 PROC	1.03e-03	124	67	4	IPR001881
Domain	SEA	TMPRSS15 AGRN	1.12e-03	14	67	2	SM00200
Domain	FN_type2_col-bd	IGF2R F12	1.12e-03	14	67	2	IPR000562
Domain	FN2_2	IGF2R F12	1.12e-03	14	67	2	PS51092
Domain	Gla	F2 PROC	1.12e-03	14	67	2	PF00594
Domain	fn2	IGF2R F12	1.12e-03	14	67	2	PF00040
Domain	GLA	F2 PROC	1.12e-03	14	67	2	SM00069
Domain	FN2_1	IGF2R F12	1.12e-03	14	67	2	PS00023
Domain	FN2	IGF2R F12	1.12e-03	14	67	2	SM00059
Domain	GLA_1	F2 PROC	1.12e-03	14	67	2	PS00011
Domain	GLA_domain	F2 PROC	1.12e-03	14	67	2	IPR000294
Domain	GLA_2	F2 PROC	1.12e-03	14	67	2	PS50998
Domain	-	TMPRSS15 AGRN	1.29e-03	15	67	2	3.30.70.960
Domain	EGF_3	NRXN1 AGRN F12 NOTCH3 PROC	1.55e-03	235	67	5	PS50026
Domain	EGF	NRXN1 AGRN F12 NOTCH3 PROC	1.55e-03	235	67	5	SM00181
Domain	Kringle	F2 F12	1.67e-03	17	67	2	IPR000001
Domain	Kringle_CS	F2 F12	1.67e-03	17	67	2	IPR018056
Domain	KRINGLE_2	F2 F12	1.67e-03	17	67	2	PS50070
Domain	Kringle	F2 F12	1.67e-03	17	67	2	PF00051
Domain	KRINGLE_1	F2 F12	1.67e-03	17	67	2	PS00021
Domain	KR	F2 F12	1.67e-03	17	67	2	SM00130
Domain	ZINC_FINGER_C2H2_2	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	1.72e-03	775	67	9	PS50157
Domain	ZINC_FINGER_C2H2_1	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	1.75e-03	777	67	9	PS00028
Domain	EGF-like_dom	NRXN1 AGRN F12 NOTCH3 PROC	1.99e-03	249	67	5	IPR000742
Domain	EGF_1	NRXN1 AGRN F12 NOTCH3 PROC	2.21e-03	255	67	5	PS00022
Domain	EGF-like_CS	NRXN1 AGRN F12 NOTCH3 PROC	2.45e-03	261	67	5	IPR013032
Domain	EGF_2	NRXN1 AGRN F12 NOTCH3 PROC	2.61e-03	265	67	5	PS01186
Domain	SEA	TMPRSS15 AGRN	2.80e-03	22	67	2	PF01390
Domain	HAD-like_dom	PITPNM1 CTDP1 ATP2B3	2.87e-03	79	67	3	IPR023214
Domain	SEA	TMPRSS15 AGRN	3.06e-03	23	67	2	PS50024
Domain	SEA_dom	TMPRSS15 AGRN	3.06e-03	23	67	2	IPR000082
Domain	-	NRXN1 PTX3 AGRN	4.83e-03	95	67	3	2.60.120.200
Domain	ASX_HYDROXYL	NRXN1 NOTCH3 PROC	5.57e-03	100	67	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NRXN1 NOTCH3 PROC	6.54e-03	106	67	3	IPR000152
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNA1C CACNA1S COL6A5 AGRN	1.42e-05	42	50	4	M7169
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F2 F12 PROC	7.07e-05	23	50	3	M15997
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F2 F12 PROC	7.07e-05	23	50	3	M14766
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F2 F12 PROC	7.07e-05	23	50	3	MM1427
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F2 F12 PROC	7.07e-05	23	50	3	MM14557
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	CACNA1C CACNA1S COL6A5 AGRN	7.15e-05	63	50	4	M11187
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	CACNA1C CACNA1S SLC8A1 TCF7L2	1.34e-04	74	50	4	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	CACNA1C CACNA1S SLC8A1 TCF7L2	1.34e-04	74	50	4	M16376
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1S	1.83e-04	6	50	2	M47762
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	CACNA1C SLC8A1 ATP2B3	2.76e-04	36	50	3	M39831
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	F2 F12 PROC	3.51e-04	39	50	3	M2844
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	F2 F12 PROC	3.51e-04	39	50	3	MM14559
Pathway	REACTOME_TRANSPORT_OF_GAMMA_CARBOXYLATED_PROTEIN_PRECURSORS_FROM_THE_ENDOPLASMIC_RETICULUM_TO_THE_GOLGI_APPARATUS	F2 PROC	4.37e-04	9	50	2	MM14614
Pathway	REACTOME_GAMMA_CARBOXYLATION_OF_PROTEIN_PRECURSORS	F2 PROC	4.37e-04	9	50	2	MM14613
Pathway	REACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS	F2 PROC	5.45e-04	10	50	2	M26977
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F2 PROC	6.64e-04	11	50	2	M12484
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1C CACNA1S	6.64e-04	11	50	2	M47958
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F2 PROC	6.64e-04	11	50	2	MM14615
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	SLC8A1 ATP2B3	7.95e-04	12	50	2	M27326
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	F2 PROC	9.38e-04	13	50	2	M4470
Pathway	WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS	F2 PROC	9.38e-04	13	50	2	M45518
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	F2 PROC	9.38e-04	13	50	2	MM1395
Pathway	REACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2	GPC3 AGRN	1.09e-03	14	50	2	M27263
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	SLC8A1 ATP2B3	1.09e-03	14	50	2	MM15052
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C CACNA1S	1.09e-03	14	50	2	M47692
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	F2 F12 PROC	1.13e-03	58	50	3	M39649
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	CACNA1C CACNA1S KRT13 TCF7L2 CTCF DMKN ZNF423 PSMB10 KRT20 COL6A5 FOXA3 PRDM16 AGRN	1.14e-03	1432	50	13	M509
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	F2 F12 PROC	1.19e-03	59	50	3	M48343
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	DDR1 NRXN1 AGRN	1.19e-03	59	50	3	M27218
Pathway	REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS	F2 F12	1.43e-03	16	50	2	M38996
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1C CACNA1S SLC8A1 ATP2B3	1.80e-03	147	50	4	MM15854
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	F2 F12 PROC	1.87e-03	69	50	3	M16894
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1C CACNA1S SLC8A1 ATP2B3	1.99e-03	151	50	4	M39329
Pathway	REACTOME_ATTACHMENT_AND_ENTRY	GPC3 AGRN	2.03e-03	19	50	2	M41729
Pathway	REACTOME_DISEASES_OF_HEMOSTASIS	F2 F12	2.03e-03	19	50	2	M48230
Pathway	REACTOME_DEFECTIVE_B4GALT7_CAUSES_EDS_PROGEROID_TYPE	GPC3 AGRN	2.25e-03	20	50	2	M27258
Pathway	BIOCARTA_AMI_PATHWAY	F2 PROC	2.25e-03	20	50	2	M15394
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTU BCL11B GOPC ARHGAP23 LBX1 TRIP6 CTCF PER1 HIC2 PPP6R1 LTK PRDM16 FAM83H	1.81e-07	1116	67	13	31753913
Pubmed	Oxidative stress regulates progenitor behavior and cortical neurogenesis.	BCL11B PTX3 PRDM16	1.12e-06	11	67	3	32041791
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	IGF2R MEX3D CTDP1 PER1 PSMB10 PCNX1 PPP6R1 LTK PRDM16 AGRN KIFC2 FAM83H	1.19e-06	1105	67	12	35748872
Pubmed	Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells.	CACNA1C CACNA1S	3.66e-06	2	67	2	25277766
Pubmed	Hyperprothrombinaemia-induced APC resistance: differential influence on fibrin formation and fibrinolysis.	F2 PROC	3.66e-06	2	67	2	16601829
Pubmed	Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients.	F2 PROC	3.66e-06	2	67	2	21430357
Pubmed	Effect of cardiopulmonary bypass on thrombin generation and protein C pathway.	F2 PROC	3.66e-06	2	67	2	23312776
Pubmed	A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice.	CACNA1C CACNA1S	3.66e-06	2	67	2	1281468
Pubmed	Exposure of R169 controls protein C activation and autoactivation.	F2 PROC	3.66e-06	2	67	2	22535660
Pubmed	Genetic Background Limits Generalizability of Genotype-Phenotype Relationships.	CACNA1C TCF7L2	3.66e-06	2	67	2	27618673
Pubmed	O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C.	F12 PROC	3.66e-06	2	67	2	1544894
Pubmed	Endogenous cardiac Ca2+ channels do not overcome the E-C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link.	CACNA1C CACNA1S	3.66e-06	2	67	2	7635187
Pubmed	Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases.	GPC3 KRT20	3.66e-06	2	67	2	18813128
Pubmed	Solution structure of the BRK domains from CHD7.	CTCF CHD7	3.66e-06	2	67	2	17603073
Pubmed	Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women.	CACNA1C SLC8A1	3.66e-06	2	67	2	28807015
Pubmed	Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.	CACNA1C SLC8A1	3.66e-06	2	67	2	19230140
Pubmed	The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.	BCL11B PTX3 PRDM16	1.03e-05	22	67	3	29779941
Pubmed	A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.	TRADD CTCF PSMB10	1.03e-05	22	67	3	12417987
Pubmed	Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels.	CACNA1C CACNA1S	1.10e-05	3	67	2	9668070
Pubmed	Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling.	F2 PROC	1.10e-05	3	67	2	15769747
Pubmed	Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.	CACNA1C SLC8A1	1.10e-05	3	67	2	21832054
Pubmed	Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells.	F2 F12	1.10e-05	3	67	2	29075790
Pubmed	Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.	F2 PROC	1.10e-05	3	67	2	16418283
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1C CACNA1S	1.10e-05	3	67	2	17289261
Pubmed	PAR1 cleavage and signaling in response to activated protein C and thrombin.	F2 PROC	1.10e-05	3	67	2	15665002
Pubmed	Activated protein C concentrate treatment for skin necrosis under warfarin treatment in severe genetic protein C deficiency combined with prothrombin mutation and factor V Leiden.	F2 PROC	1.10e-05	3	67	2	19190829
Pubmed	Homozygosity for the C46T polymorphism of the F12 gene is a risk factor for venous thrombosis during the first pregnancy.	F2 F12	1.10e-05	3	67	2	17408404
Pubmed	Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin.	F2 PROC	1.10e-05	3	67	2	12588872
Pubmed	Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.	F2 F12	1.10e-05	3	67	2	18765660
Pubmed	Engineering thrombin for selective specificity toward protein C and PAR1.	F2 PROC	1.10e-05	3	67	2	20404340
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1S	1.10e-05	3	67	2	17767505
Pubmed	Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome.	F12 PROC	1.10e-05	3	67	2	25879167
Pubmed	Rapid triplex asymmetric real-time PCR hybridization probe assay for the joint genotyping of F2, F5 and F12.	F2 F12	1.10e-05	3	67	2	19422815
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1C CACNA1S	1.10e-05	3	67	2	11206130
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1S	1.10e-05	3	67	2	2173707
Pubmed	Associated measurement of fucosylated levels of AFP, DCP, and GPC3 for early diagnosis in hepatocellular carcinoma.	GPC3 F2	1.10e-05	3	67	2	30854929
Pubmed	mRNA for cardiac calcium channel is expressed during development of skeletal muscle.	CACNA1C CACNA1S	1.10e-05	3	67	2	8381753
Pubmed	The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions.	F2 PROC	1.10e-05	3	67	2	15705565
Pubmed	Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.	F2 PROC	1.10e-05	3	67	2	15582990
Pubmed	Molecular reconstruction and homology modelling of the catalytic domain of the common ancestor of the haemostatic vitamin-K-dependent serine proteinases.	F2 PROC	1.10e-05	3	67	2	8707309
Pubmed	Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation.	F2 PROC	1.10e-05	3	67	2	25149909
Pubmed	Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin.	F2 PROC	1.10e-05	3	67	2	18089851
Pubmed	How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.	F2 PROC	1.10e-05	3	67	2	34978431
Pubmed	Five prothrombotic polymorphisms and the prevalence of premature myocardial infarction.	F2 F12	1.10e-05	3	67	2	15749685
Pubmed	Factor V Leiden, prothrombin G20210A, and protein C mutation frequency in Turkish venous thrombosis patients.	F2 PROC	1.10e-05	3	67	2	18160601
Pubmed	Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin.	F2 PROC	1.10e-05	3	67	2	2544585
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	BCL11B IGF2R NRXN1 CTCF ZBTB22 CHD7 PPP6R1 CTNND2 AGRN BEGAIN	1.50e-05	963	67	10	28671696
Pubmed	The roles of protein C and thrombomodulin in the regulation of blood coagulation.	F2 PROC	2.19e-05	4	67	2	2538457
Pubmed	Recurrent CNVs disrupt three candidate genes in schizophrenia patients.	NRXN1 CTNND2	2.19e-05	4	67	2	18940311
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1S	2.19e-05	4	67	2	20937870
Pubmed	Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.	F2 PROC	2.19e-05	4	67	2	18198180
Pubmed	Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.	F2 PROC	2.19e-05	4	67	2	29363996
Pubmed	The mechanism of inactivation of human factor V and human factor Va by activated protein C.	F2 PROC	2.19e-05	4	67	2	7989361
Pubmed	Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma.	IGF2R CTCF	2.19e-05	4	67	2	18604514
Pubmed	Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.	F2 PROC	2.19e-05	4	67	2	37660436
Pubmed	Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.	IGF2R GPC3	2.19e-05	4	67	2	9853964
Pubmed	Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.	F2 PROC	2.19e-05	4	67	2	10026263
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	GPC3 AGRN NOTCH3	2.96e-05	31	67	3	11431694
Pubmed	Major and potential prothrombotic genotypes in patients with venous thrombosis and in healthy subjects from Slovenia.	F2 F12	3.64e-05	5	67	2	19127083
Pubmed	Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression.	BCL11B IGF2R	3.64e-05	5	67	2	31388182
Pubmed	Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase.	F2 PROC	3.64e-05	5	67	2	20881312
Pubmed	The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.	F2 F12	3.64e-05	5	67	2	19415820
Pubmed	Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris.	F2 PROC	3.64e-05	5	67	2	7548163
Pubmed	Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.	CACNA1C SLC8A1	3.64e-05	5	67	2	22355118
Pubmed	Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin.	F2 PROC	3.64e-05	5	67	2	27561318
Pubmed	The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.	CACNA1C CACNA1S	3.64e-05	5	67	2	1335956
Pubmed	Early embryonic expression of murine coagulation system components.	F2 F12 PROC	3.92e-05	34	67	3	11154109
Pubmed	Heart neurons use clock genes to control myocyte proliferation.	CACNA1C SLC8A1 PER1	5.07e-05	37	67	3	34851661
Pubmed	Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN.	F2 PROC	5.46e-05	6	67	2	9252393
Pubmed	An unfavorable combination of Factor V Leiden with age, weight, and blood group causes high risk of pregnancy-associated venous thrombosis: a population-based nested case-control study.	F2 PROC	5.46e-05	6	67	2	16765424
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	SLC8A1 ATP2B3	5.46e-05	6	67	2	12767889
Pubmed	Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.	F2 F12	5.46e-05	6	67	2	16157382
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1C SLC8A1 ATP2B3	5.49e-05	38	67	3	30786075
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	KRT13 NRXN1 CTNND2 ATP2B3	6.23e-05	110	67	4	27889896
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	NRXN1 PCNX1 HIC2 CHD7 PRDM16	7.55e-05	225	67	5	12168954
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1S	7.63e-05	7	67	2	12900400
Pubmed	PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.	F2 PROC	7.63e-05	7	67	2	26457757
Pubmed	Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.	CACNA1C CACNA1S	7.63e-05	7	67	2	9004034
Pubmed	Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis.	F2 PROC	7.63e-05	7	67	2	19682239
Pubmed	Gender differences in genetic risk profiles for cardiovascular disease.	F2 F12 PROC	9.78e-05	46	67	3	18974842
Pubmed	ABO blood group but not haemostasis genetic polymorphisms significantly influence thrombotic risk: a study of 180 homozygotes for the Factor V Leiden mutation.	F2 PROC	1.02e-04	8	67	2	17107352
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	CACNA1C SLC8A1	1.02e-04	8	67	2	21737792
Pubmed	Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.	ZNF423 PER1 SLCO3A1	1.04e-04	47	67	3	18821565
Pubmed	Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.	IGF2R CTCF	1.30e-04	9	67	2	25918552
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	CACNA1C NRXN1	1.30e-04	9	67	2	23010509
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1S	1.30e-04	9	67	2	16382099
Pubmed	Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation.	F2 PROC	1.30e-04	9	67	2	17704111
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	TTBK1 ARMC10 HIC2 PPP6R1 KIFC2	1.41e-04	257	67	5	30945288
Pubmed	LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.	BCL11B LTK	1.63e-04	10	67	2	37291945
Pubmed	The REST remodeling complex protects genomic integrity during embryonic neurogenesis.	TRADD BCL11B NOTCH3	1.86e-04	57	67	3	26745185
Pubmed	Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.	TCF7L2 BCL11B	1.99e-04	11	67	2	29751817
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GOPC DMKN PER1 HIC2 PPP6R1 FOXA3 ATP2B3 NOTCH3	2.38e-04	857	67	8	25609649
Pubmed	Dual effect of CTCF loss on neuroprogenitor differentiation and survival.	BCL11B CTCF	2.38e-04	12	67	2	24553927
Pubmed	Gene variants associated with venous thrombosis: confirmation in the MEGA study.	F2 PROC	2.38e-04	12	67	2	20128871
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	CACNA1C SLC8A1	2.38e-04	12	67	2	19095005
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	BCL11B ZBTB22 HIC2	2.50e-04	63	67	3	34351428
Pubmed	Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.	PITPNM1 BCL11B ATP2B3	2.62e-04	64	67	3	20798045
Pubmed	Genetic determinants of warfarin dosing in the Han-Chinese population.	F2 PROC	2.81e-04	13	67	2	19958090
Pubmed	Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.	CACNA1C CACNA1S NRXN1	3.00e-04	67	67	3	16987237
Pubmed	Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.	GPC3 AGRN	3.28e-04	14	67	2	37408198
Cytoband	8q24.3	ADGRB1 KIFC2 FAM83H	6.20e-04	113	67	3	8q24.3
Cytoband	18q23	CTDP1 ZNF407	8.30e-04	29	67	2	18q23
Cytoband	14q32.2	BCL11B BEGAIN	1.43e-03	38	67	2	14q32.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	TRADD CTCF PSMB10	2.47e-03	183	67	3	chr16q22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BCL11B CTCF ZNF366 ZNF423 ZBTB22 ZNF407 HIC2 PRDM16 ZNF513	1.15e-04	718	49	9	28
GeneFamily	Gla domain containing	F2 PROC	5.51e-04	13	49	2	1250
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1S	2.24e-03	26	49	2	253
GeneFamily	Keratins, type I	KRT13 KRT20	2.60e-03	28	49	2	608
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	DDR1 LTK	5.26e-03	40	49	2	321
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC10 CTNND2	6.05e-03	43	49	2	409
GeneFamily	PDZ domain containing	INTU GOPC ARHGAP23	8.09e-03	152	49	3	1220
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NE_PRECURSOR_CELL	NRXN1 NAP1L5 SLCO3A1 HIC2 ZFTA TUT1 PPP6R1 FOXA3 PROC	1.43e-06	429	67	9	M45694
Coexpression	GSE27670_CTRL_VS_BLIMP1_TRANSDUCED_GC_BCELL_UP	KRT13 PTX3 PER1 ARMC10 LTK F2	1.24e-05	200	67	6	M8212
Coexpression	HARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP	TRADD SLC8A1 ERICH3 ARHGAP23 TRIP6 ZNF366 ADGRB1 CTNND2 PRDM16 AGRN VWA5B1	3.34e-05	973	67	11	M41080
Coexpression	PDGF_ERK_DN.V1_DN	PITPNM1 KRT13 PER1 HIC2 PPP6R1	4.04e-05	149	67	5	M2828
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMPRSS15 BCL11B NAP1L5 RP1L1 F12	1.34e-06	126	67	5	54247ce9ee0a4f123f1fb225600a4ec698510a86
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC8A1 NRXN1 ADGRB1 SLCO3A1 NOTCH3	8.30e-06	183	67	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CACNA1C SLC8A1 GPC3 NRXN1 DMKN	8.98e-06	186	67	5	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C GPC3 PTX3 SLCO3A1 COL6A5	1.05e-05	192	67	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 KRT13 GPC3 DMKN AGRN	1.13e-05	195	67	5	66caa5c063184e7d3d653c8f6c289555cb36fa82
ToppCell	facs-Tongue\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 KRT13 BCL11B DMKN FAM83H	1.13e-05	195	67	5	77128895db9221a64a171082d468ebcd6380c936
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 KRT13 GPC3 DMKN AGRN	1.13e-05	195	67	5	ed74c113074fb5d3c42f2330b0e6042d32c3611a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 KRT13 GPC3 DMKN AGRN	1.13e-05	195	67	5	17c4d3b59cd0d79ce9ae5dde95586f3e923db16f
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37\|World / Primary Cells by Cluster	BCL11B NRXN1 NAP1L5 CTNND2 F12	1.19e-05	197	67	5	00d756bc0231e1b3b88430214338c1059cb11106
ToppCell	Transverse-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	TRADD ZNF366 ZNF407 FAM83H ZNF513	1.19e-05	197	67	5	a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCell	Calu_3\|World / Cell line, Condition and Strain	DDR1 DMKN SLCO3A1 AGRN FAM83H	1.27e-05	200	67	5	a549aa08aeefe905653266dae3936094ff55f8e4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TMPRSS15 GPC3 COL6A5	3.80e-05	125	67	4	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 F12 SEMA4G PROC	7.14e-05	147	67	4	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	RIPOR2 IGF2R ZNF366 PCNX1	8.13e-05	152	67	4	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ERICH3 DMKN LTK PROC	8.34e-05	153	67	4	fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ERICH3 DMKN LTK PROC	8.34e-05	153	67	4	2482247d9c39c7b99bb45fb9153442f64fd6012f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRADD TMPRSS15 ZBTB22 FAM124A	8.56e-05	154	67	4	89c9c9918af32f3952790b41f1471b2c80ffce2f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RP1L1 CTNND2 F2 BEGAIN	8.56e-05	154	67	4	1899138c096c08d8aee6b1970b7c0081e14c88a8
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC8A1 ZNF407 FGD5 KIFC2	8.56e-05	154	67	4	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZNF423 FGD5 FOXA3 PRDM16	9.45e-05	158	67	4	4f3ea658e032555c2098d016475381c8d1071699
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-3\|TCGA-Pancreas / Sample_Type by Project: Shred V9	RIN1 LRRC66 F12 SEMA4G	9.45e-05	158	67	4	ec1a71b8f46179642b5af20e27764bb43c4b8e99
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ZNF366 ZNF423 CTNND2	9.92e-05	160	67	4	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	facs-Spleen-nan-3m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 ZNF366	1.02e-04	161	67	4	45591addc765760db6029ac19e80573373d1d917
ToppCell	facs-Spleen-nan-3m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 ZNF366	1.02e-04	161	67	4	8741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCell	facs-Spleen-nan-3m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 ZNF366	1.02e-04	161	67	4	9cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	BCL11B CTDP1 ZNF407 FAM124A	1.02e-04	161	67	4	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRADD ZNF423 FGD5 LTK	1.09e-04	164	67	4	e86899aa68aac572009618c7e017e6734b86357c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	BCL11B TTBK1 NRXN1 ATP2B3	1.12e-04	165	67	4	9795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCell	droplet-Spleen-nan-3m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 TCF7L2 ZNF366 CTNND2	1.14e-04	166	67	4	c1f18de4a1a2b6cdc703e6d29d136e1134fcbdf3
ToppCell	droplet-Spleen-nan-3m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 TCF7L2 ZNF366 CTNND2	1.14e-04	166	67	4	94c30d6ca179d0cb02a5ed0093c5a2871e17ae50
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	LBX1 LTK SEMA4G FAM83H	1.17e-04	167	67	4	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	LBX1 LTK SEMA4G FAM83H	1.17e-04	167	67	4	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 F12 SEMA4G PROC	1.20e-04	168	67	4	b98af4043dfa5dfa4413e482879fad88de484675
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 F12 SEMA4G PROC	1.20e-04	168	67	4	073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 CTNND2	1.22e-04	169	67	4	3f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 CTNND2	1.22e-04	169	67	4	26de495c7562e0740689d0f78e803698e3e793db
ToppCell	droplet-Liver-HEPATOCYTES\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 F12 SEMA4G PROC	1.22e-04	169	67	4	f195467438c589f87224bde7da720dea072d110c
ToppCell	droplet-Liver-HEPATOCYTES-1m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 F12 SEMA4G PROC	1.22e-04	169	67	4	7785cab967a33560830c394c918d6ce625103858
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP23 HIC2 LTK PROC	1.22e-04	169	67	4	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTDP1 KRT20 FOXA3 SEMA4G	1.22e-04	169	67	4	1dfaf9a6b433a5ee86a11962af188978c2543278
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTDP1 KRT20 FOXA3 SEMA4G	1.22e-04	169	67	4	3e267ec9f884df326315500dfd751b04a3dd91bd
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	IGF2R CHD7 LTK NOTCH3	1.25e-04	170	67	4	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	BCL11B CTNND2 FOXA3 PRDM16	1.25e-04	170	67	4	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 TCF7L2 CTNND2	1.25e-04	170	67	4	670027daec5a10dfa12246f1497b58db21d32a22
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C NRXN1 ADGRB1 NOTCH3	1.25e-04	170	67	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 ZNF366 CTNND2	1.28e-04	171	67	4	4a2e6ea9674bf23e8012ef0bb2bf19ce1f55fcd5
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 ZNF366 CTNND2	1.28e-04	171	67	4	5b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	NRXN1 CTNND2 FOXA3 PROC	1.28e-04	171	67	4	b7cddb8f726a43fb8a37f3e67a3f722e2178fd7a
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C FOXA3 ATP2B3 NOTCH3	1.31e-04	172	67	4	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	droplet-Spleen-nan-18m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 ZNF366 CTNND2	1.31e-04	172	67	4	850e4c9e9003807c19695be4b13121b0808a9389
ToppCell	droplet-Spleen-nan-18m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SLC8A1 ZNF366 CTNND2	1.31e-04	172	67	4	018d8160cfcb7882475620dc678f48a69a0f643e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR2 ZNF366 SLCO3A1 BEGAIN	1.34e-04	173	67	4	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C LRRC66 COL6A5 NOTCH3	1.34e-04	173	67	4	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIPOR2 BCL11B TTBK1 LTK	1.34e-04	173	67	4	15a77f6aac968b7a1afea4f60aedbb95b9d0f765
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF366 ZNF423 FGD5 LTK	1.34e-04	173	67	4	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	droplet-Thymus-nan-3m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 NRXN1 ZNF366 CTNND2	1.34e-04	173	67	4	63f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PITPNM1 KRT13 ARHGAP23 NOTCH3	1.37e-04	174	67	4	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGF2R NRXN1 NOTCH3 BEGAIN	1.40e-04	175	67	4	fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN1 LTK VWA5B1 FAM83H	1.40e-04	175	67	4	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP23 SLCO3A1 ZFTA NOTCH3	1.40e-04	175	67	4	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	RIPOR2 ARHGAP23 HIC2 LTK	1.40e-04	175	67	4	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN1 LTK VWA5B1 FAM83H	1.40e-04	175	67	4	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 KRT20 PRDM16 NOTCH3	1.40e-04	175	67	4	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 KRT20 PRDM16 NOTCH3	1.40e-04	175	67	4	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT13 RIPOR2 BCL11B ATP2B3	1.43e-04	176	67	4	acd05ca8952710feedbfe377b1330f3c2406d044
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 PTX3 ZNF423 ZFTA	1.43e-04	176	67	4	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 PTX3 ZNF423 ZFTA	1.43e-04	176	67	4	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEX3D NAP1L5 SLCO3A1 NOTCH3	1.46e-04	177	67	4	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEX3D NAP1L5 SLCO3A1 NOTCH3	1.46e-04	177	67	4	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPC3 NRXN1 DMKN CTNND2	1.46e-04	177	67	4	75cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT13 BCL11B GPC3 PER1	1.46e-04	177	67	4	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DDR1 TMPRSS15 NRXN1 CHD7	1.49e-04	178	67	4	13dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B TTBK1 ATP2B3 BEGAIN	1.49e-04	178	67	4	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC3 ARHGAP23 SLCO3A1 F12	1.49e-04	178	67	4	d9eba884e18a0c89bdc70c194bfe4d62cca164fa
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC3 ARHGAP23 SLCO3A1 F12	1.49e-04	178	67	4	b03aa1de9d20895ebad55f6fcd6fe7a49335db5a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B TTBK1 ATP2B3 BEGAIN	1.49e-04	178	67	4	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DDR1 TMPRSS15 NRXN1 CHD7	1.49e-04	178	67	4	a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC3 ARHGAP23 SLCO3A1 F12	1.49e-04	178	67	4	0f5cf34609df791c8baebfdc6590f6eb4dbe0509
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRADD BCL11B PER1 LTK	1.53e-04	179	67	4	b0585a8e596c3d8e434af943e65207fa5877600d
ToppCell	E15.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RIPOR2 IGF2R NOTCH3 BEGAIN	1.56e-04	180	67	4	38035cf2c6fbc443ea10ca7e942572715ed572da
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 PRDM16 AGRN KIFC2	1.59e-04	181	67	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	GPC3 NRXN1 SLCO3A1 AGRN	1.63e-04	182	67	4	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	Mild-CD4+_T\|World / Disease group and Cell class	TRADD RIPOR2 FGD5 BEGAIN	1.66e-04	183	67	4	c4ac8893d38a3da4e19fe2ef1756bd69c89e975c
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	CACNA1C SLC8A1 PRDM16 NOTCH3	1.66e-04	183	67	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ZNF366 ZNF423 FGD5	1.66e-04	183	67	4	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NAP1L5 COL6A5 FAM124A PRDM16	1.66e-04	183	67	4	5377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C ZNF366 ZNF423 FGD5	1.66e-04	183	67	4	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC8A1 NRXN1 ADGRB1 NOTCH3	1.70e-04	184	67	4	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 ARHGAP23 FAM124A CHD7	1.70e-04	184	67	4	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTBK1 NRXN1 NAP1L5 NOTCH3	1.73e-04	185	67	4	c4ef8d9f8b9769e887daac4efd9dc05738b28ae2
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTBK1 NRXN1 NAP1L5 NOTCH3	1.73e-04	185	67	4	10ddf38d908525b4258f9d2da8be4c56ebc08ff4
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTBK1 NRXN1 NAP1L5 KIFC2	1.77e-04	186	67	4	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC3 NRXN1 NAP1L5 NOTCH3	1.81e-04	187	67	4	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC3 NRXN1 NAP1L5 NOTCH3	1.81e-04	187	67	4	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 ARHGAP23 FAM124A CHD7	1.81e-04	187	67	4	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C GPC3 PTX3 COL6A5	1.81e-04	187	67	4	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRADD BCL11B PER1 LTK	1.84e-04	188	67	4	3e3055dacc05a932f2beb114babf1dc76994e1af
ToppCell	systemic_lupus_erythematosus-flare-Hematopoietic\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RIPOR2 BCL11B ZNF423 FGD5	1.84e-04	188	67	4	88b808561ebde997ac8a8bbd1d9bbda49bbb6646
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CACNA1C SLC8A1 PRDM16 NOTCH3	1.84e-04	188	67	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF366 ZNF423 FGD5 CTNND2	1.84e-04	188	67	4	789d1be574e693d7bdd488f3c72c6df788e47b47
Computational	Blood coagulation factors.	F2 F12 PROC	1.76e-04	33	36	3	MODULE_131
Computational	Serine proteases.	F2 F12 PROC	2.90e-04	39	36	3	MODULE_109
Computational	Neighborhood of CYP2B6	F2 F12 PROC	5.72e-04	49	36	3	GNF2_CYP2B6
Drug	BAEE	TMPRSS15 PSMB10 F2 F12 PROC	1.26e-06	64	67	5	CID000123880
Drug	5186223; Up 200; 12uM; MCF7; HT_HG-U133A_EA	TCF7L2 ZNF423 PER1 PCNX1 CTNND2 PROC BEGAIN	2.02e-06	200	67	7	885_UP
Drug	NPGB	PSMB10 F2 F12 PROC	6.39e-06	41	67	4	CID000030744
Drug	Mometasone furoate [83919-23-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	KRT13 TCF7L2 BCL11B PCNX1 HIC2 NOTCH3	1.87e-05	187	67	6	2896_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	KRT13 TCF7L2 BCL11B MEX3D CTDP1 PCNX1	2.23e-05	193	67	6	5566_DN
Drug	Avermectin B1 [71751-41-2]; Up 200; 4.8uM; MCF7; HT_HG-U133A	PITPNM1 CACNA1S HIC2 TUT1 SEMA4G BEGAIN	2.30e-05	194	67	6	6081_UP
Drug	Adiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; PC3; HT_HG-U133A	BCL11B GPC3 MEX3D PER1 TUT1 CTNND2	2.57e-05	198	67	6	7279_UP
Drug	Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; MCF7; HT_HG-U133A	GPC3 ZNF423 CTDP1 SLCO3A1 TUT1 NOTCH3	2.57e-05	198	67	6	3581_DN
Drug	Sulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	TMPRSS15 LBX1 SLCO3A1 HIC2 SEMA4G BEGAIN	2.72e-05	200	67	6	4740_UP
Drug	PHA-00851261E [724719-49-7]; Up 200; 1uM; PC3; HT_HG-U133A	SLC8A1 GPC3 SLCO3A1 HIC2 LTK PROC	2.72e-05	200	67	6	3776_UP
Drug	Phe-arg	INTU TMPRSS15 PSMB10 F12	3.36e-05	62	67	4	CID000150903
Drug	tranexamic acid	DNAJB7 F2 F12 PROC	3.81e-05	64	67	4	CID000005526
Drug	1i9n	PER1 CHD7 F12	5.35e-05	25	67	3	CID000446239
Disease	Thromboembolism	F2 F12 PROC	2.32e-06	12	66	3	C0040038
Disease	acquired angioedema (is_marker_for)	F2 F12	1.48e-05	3	66	2	DOID:0080941 (is_marker_for)
Disease	hereditary angioedema (is_marker_for)	F2 F12	2.95e-05	4	66	2	DOID:14735 (is_marker_for)
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1S	2.95e-05	4	66	2	DOID:0060173 (implicated_via_orthology)
Disease	risk-taking behaviour	CACNA1C TCF7L2 BCL11B TTBK1 NRXN1 ZNF423 RP1L1 ADGRB1 PROC	4.94e-05	764	66	9	EFO_0008579
Disease	albuminuria	TCF7L2 NRXN1 CHD7 LTK	5.98e-05	94	66	4	EFO_0004285
Disease	Disseminated Intravascular Coagulation	F2 PROC	1.03e-04	7	66	2	C0012739
Disease	lymphocyte percentage of leukocytes	CACNA1S SLC8A1 RIPOR2 BCL11B ZNF366 CHD7 LTK PRDM16	1.16e-04	665	66	8	EFO_0007993
Disease	thrombin measurement	F2 F12	1.37e-04	8	66	2	EFO_0020768
Disease	Venous Thromboembolism	F2 PROC	1.37e-04	8	66	2	C1861172
Disease	Thrombophilia due to thrombin defect	F2 PROC	1.37e-04	8	66	2	cv:C3160733
Disease	coffee consumption measurement, insomnia	TCF7L2 PROC	2.19e-04	10	66	2	EFO_0004698, EFO_0006781
Disease	disseminated intravascular coagulation (is_marker_for)	F2 PROC	2.19e-04	10	66	2	DOID:11247 (is_marker_for)
Disease	hyperhomocysteinemia (implicated_via_orthology)	F2 F12	2.68e-04	11	66	2	DOID:9279 (implicated_via_orthology)
Disease	response to bronchodilator, FEV/FEC ratio	CACNA1C RIPOR2 TCF7L2 NRXN1 RP1L1 SLCO3A1 TUT1 PRDM16	3.03e-04	766	66	8	EFO_0004713, GO_0097366
Disease	Migraine Disorders	PRDM16 NOTCH3	3.78e-04	13	66	2	C0149931
Disease	skin melanoma (is_implicated_in)	DDR1 CTCF	4.41e-04	14	66	2	DOID:8923 (is_implicated_in)
Disease	Impaired cognition	CACNA1C NOTCH3	4.41e-04	14	66	2	C0338656
Disease	nephroblastoma (is_implicated_in)	IGF2R GPC3	4.41e-04	14	66	2	DOID:2154 (is_implicated_in)
Disease	thrombosis (is_implicated_in)	F2 PROC	5.08e-04	15	66	2	DOID:0060903 (is_implicated_in)
Disease	cutaneous Leishmaniasis	TCF7L2 PPP6R1	5.79e-04	16	66	2	EFO_0005046
Disease	hypertension	TTBK1 ZNF423 COL6A5 FGD5 PRDM16	6.28e-04	307	66	5	EFO_0000537
Disease	Schizophrenia	PITPNM1 CACNA1C DDR1 TCF7L2 NRXN1 CTCF CTNND2 F2	7.72e-04	883	66	8	C0036341
Disease	toxic shock syndrome (is_marker_for)	PTX3 F2	8.22e-04	19	66	2	DOID:14115 (is_marker_for)
Disease	autism spectrum disorder, schizophrenia	CACNA1C DDR1 TCF7L2 PCNX1 F2	8.33e-04	327	66	5	EFO_0003756, MONDO_0005090
Disease	Hypertensive disease	CACNA1C ATP2B3 F12 PROC	8.79e-04	190	66	4	C0020538
Disease	sex interaction measurement, cerebral amyloid angiopathy	ARHGAP23 FAM124A	1.01e-03	21	66	2	EFO_0006790, EFO_0008343
Disease	Deep Vein Thrombosis	F2 PROC	1.01e-03	21	66	2	C0149871
Disease	Venous Thrombosis	F2 PROC	1.01e-03	21	66	2	C0042487
Disease	Immunologic Deficiency Syndromes	CACNA1C CHD7	1.21e-03	23	66	2	C0021051
Disease	unipolar depression, schizophrenia	CACNA1C TCF7L2	1.43e-03	25	66	2	EFO_0003761, MONDO_0005090
Disease	pre-eclampsia (is_implicated_in)	F2 PROC	1.43e-03	25	66	2	DOID:10591 (is_implicated_in)
Disease	FEV change measurement, response to zileuton	NRXN1 PCNX1	1.43e-03	25	66	2	EFO_0005921, EFO_0007676
Disease	psychosis predisposition measurement	CACNA1C VWA5B1	1.55e-03	26	66	2	EFO_0008337
Disease	neuroticism measurement, cognitive function measurement	CACNA1C TCF7L2 BCL11B TTBK1 CTNND2 PROC	1.66e-03	566	66	6	EFO_0007660, EFO_0008354
Disease	alcohol consumption measurement	CACNA1C SLC8A1 TCF7L2 BCL11B NRXN1 ADGRB1 CTNND2 PRDM16 AGRN	1.72e-03	1242	66	9	EFO_0007878
Disease	corneal endothelial cell measurement	TCF7L2 GPC3 RP1L1	1.85e-03	108	66	3	EFO_0010079
Disease	self rated health	TCF7L2 PROC	2.20e-03	31	66	2	EFO_0004778

Protein segments in the cluster

Peptide	Gene	Start	Entry
GERDGLCGLGNGCAD	CTDP1	536	Q9Y5B0
CAGLEGRAEGQGGVD	ERICH3	1251	Q5RHP9
NCAGPDGVEGENGGE	CTCF	576	P49711
SEGGDGDRLGVQLCG	BEGAIN	516	Q9BUH8
GGGCEGVLEEGRQCN	ADGRB1	296	O14514
GCGSGSTEGEGEALQ	CDCP2	376	Q5VXM1
GGLGQLADGVVGLDD	DDR1	226	Q08345
SGGSGSGEDGDCEQE	AGRN	671	O00468
GEDGNIFSEGLEGLG	CHD7	11	Q9P2D1
GTDELDGLLCGEANG	CTNND2	786	Q9UQB3
ACGNVSGGAEDEGEA	ATP2B3	136	Q16720
AGALEEGTSEGQLCG	ARMC10	46	Q8N2F6
DELEGGGNPGASCKD	GOPC	396	Q9HD26
GDCGDDEDECIGGSG	GPC3	496	P51654
DGLGLDNGGGLQSDT	KIAA1109	2181	Q2LD37
EGGIDSCQGDSGGPL	TMPRSS15	961	P98073
DFGACDGGLLTGNEK	KRT13	91	P13646
GGGGEEDDCVDSGAE	FAM124A	6	Q86V42
AGRSLQEGAEGGQGC	LTK	286	P29376
GEGEGCEEAQGGAKA	PER1	1246	O15534
CNSGGNIEDSDTGGG	PCNX1	2041	Q96RV3
EREEGGEACGLEGTG	FGD5	101	Q6ZNL6
CGEGGSCVDGENGFR	NOTCH3	666	Q9UM47
LSALGLGGAGDTDEE	MEX3D	66	Q86XN8
EEGEGGVCLNGGVCS	NRXN1	221	Q9ULB1
GSDLTGGGDLFVGNE	KRT20	56	P35900
CGDNTGAGSGNDGAV	LRRC66	491	Q68CR7
CSSGGSDNGCEGGED	INTU	711	Q9ULD6
LGDRQDACEGDSGGP	PROC	391	P04070
EGLNGGGSHFDDECE	DNAJB7	71	Q7Z6W7
GDAGDDDDAGGCGDA	BCL11B	631	Q9C0K0
AGQDRAGGEEDAGCV	CACNA1C	2186	Q13936
GEALGHGLGDALSEG	DMKN	36	Q6E0U4
GGGCGNVDPDESARI	CACNA1S	1216	Q13698
DGIDGLDGEEGCHGF	COL6A5	1466	A8TX70
LEQNSEATAGGGGGC	LBX1	211	P52954
YLSGCHGEDGGDDGL	FAM83H	586	Q6ZRV2
LGAEESCGGPADLGQ	KIFC2	96	Q96AC6
GQEKNGCCVGGGFDE	PTX3	311	P26022
FLEGGTDACQGDSGG	F12	551	P00748
GSSGGCEQELGLDLS	HIC2	236	Q96JB3
EQGGCKDGGVCLLSG	IGF2R	1846	P11717
SRGEEQGCQGDGDAG	RIN1	726	Q13671
NLKCGSGARGGDGEV	TRADD	161	Q15628
GRDVCAANGSGGDEG	SLCO3A1	146	Q9UIG8
GAQGGDCDSAAGDPD	NAP1L5	31	Q96NT1
EAQGGEDVGALDCGS	FOXA3	261	P55318
EGLGGGSGQAHECKD	PRDM16	271	Q9HAZ2
GILGDLGSGGNVDAC	PSMB10	201	P40306
EDGDEVCNVGGGADS	RIPOR2	676	Q9Y4F9
EGLDGAGELGAEACA	PITPNM1	411	O00562
QLRGEGEGLCGTGSE	ZNF513	291	Q8N8E2
FGQCGGCGEDVVGDG	TRIP6	276	Q15654
AGGELGLELASDGGA	TTBK1	956	Q5TCY1
GDDEGAGGLEGSCLQ	SEMA4G	741	Q9NTN9
GGSLGEDPGLCIDGA	RP1L1	496	Q8IWN7
EEGKEEQQGCAGDGG	TUT1	671	Q9H6E5
HCSLKEEENGGRGGG	ARHGAP23	71	Q9P227
GGGGDDLGANDELIS	TCF7L2	6	Q9NQB0
EEDEEGIGCAARGGA	PPP6R1	681	Q9UPN7
GDLGAEGGQERDCAG	ZNF366	681	Q8N895
DEGKRGDACEGDSGG	F2	556	P00734
DGCDLGLGEEEGGTG	ZNF423	121	Q2M1K9
LRVHCEGEGGNAGDG	ZNF407	1226	Q9C0G0
ADELCDDGGDGRGAV	ZBTB22	261	O15209
LGLGACGEAEGLGVQ	ZFTA	171	C9JLR9
DGPGLEGGDCAKNSG	VWA5B1	611	Q5TIE3
ARGGGEDFEDTCGEL	SLC8A1	581	P32418