Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	immunoglobulin complex	IGHV4-38-2 IGHV4-61 IGHV4-34 IGHV4-30-4	2.29e-04	166	38	4	GO:0019814
Domain	Calcineurin-like_Pesterase	MPPED2 MPPED1	3.22e-06	2	34	2	IPR024201
Domain	Calcineurin-like_PHP_ApaH	MPPED2 MPPED1	1.18e-03	28	34	2	IPR004843
Domain	Metallophos	MPPED2 MPPED1	1.18e-03	28	34	2	PF00149
Domain	Metallo-depent_PP-like	MPPED2 MPPED1	1.36e-03	30	34	2	IPR029052
Domain	-	MPPED2 MPPED1	1.36e-03	30	34	2	3.60.21.10
Domain	-	PRR3 ZC3H3	2.40e-03	40	34	2	4.10.1000.10
Domain	fn3	MYLK PRLR MYOM3	3.15e-03	162	34	3	PF00041
Domain	ZnF_C3H1	PRR3 ZC3H3	3.44e-03	48	34	2	SM00356
Domain	zf-CCCH	PRR3 ZC3H3	3.59e-03	49	34	2	PF00642
Domain	FN3	MYLK PRLR MYOM3	4.57e-03	185	34	3	SM00060
Domain	Ig_I-set	MYLK WFIKKN1 MYOM3	4.92e-03	190	34	3	IPR013098
Domain	I-set	MYLK WFIKKN1 MYOM3	4.92e-03	190	34	3	PF07679
Domain	Znf_CCCH	PRR3 ZC3H3	4.99e-03	58	34	2	IPR000571
Domain	ZF_C3H1	PRR3 ZC3H3	4.99e-03	58	34	2	PS50103
Domain	FN3	MYLK PRLR MYOM3	5.59e-03	199	34	3	PS50853
Domain	FN3_dom	MYLK PRLR MYOM3	6.40e-03	209	34	3	IPR003961
Domain	-	MYLK WFIKKN1 PRLR OSCAR MYOM3	6.58e-03	663	34	5	2.60.40.10
Domain	IG	MYLK WFIKKN1 OSCAR MYOM3	6.92e-03	421	34	4	SM00409
Domain	Ig_sub	MYLK WFIKKN1 OSCAR MYOM3	6.92e-03	421	34	4	IPR003599
Domain	Ig-like_fold	MYLK WFIKKN1 PRLR OSCAR MYOM3	8.53e-03	706	34	5	IPR013783
Domain	IGc2	MYLK WFIKKN1 MYOM3	8.83e-03	235	34	3	SM00408
Domain	Ig_sub2	MYLK WFIKKN1 MYOM3	8.83e-03	235	34	3	IPR003598
Domain	IG_LIKE	MYLK WFIKKN1 OSCAR MYOM3	1.17e-02	491	34	4	PS50835
Domain	Ig-like_dom	MYLK WFIKKN1 OSCAR MYOM3	1.27e-02	503	34	4	IPR007110
Domain	PH	VAV1 PLEKHH3 TBC1D2	1.39e-02	278	34	3	SM00233
Domain	PH_DOMAIN	VAV1 PLEKHH3 TBC1D2	1.40e-02	279	34	3	PS50003
Domain	PH_domain	VAV1 PLEKHH3 TBC1D2	1.42e-02	280	34	3	IPR001849
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV4-61 IGHV4-34 VAV1	9.61e-05	53	24	3	MM15716
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV4-61 IGHV4-34 VAV1	1.26e-04	58	24	3	MM14914
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV4-61 IGHV4-34 VAV1	1.39e-04	60	24	3	MM14913
Pubmed	The 239AB gene on chromosome 22: a novel member of an ancient gene family.	MPPED2 MPPED1	1.29e-06	2	40	2	9266672
Pubmed	cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.	MPPED2 MPPED1	1.29e-06	2	40	2	8666403
Pubmed	Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line.	VAV1 PRLR	1.29e-06	2	40	2	7768923
Pubmed	Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site.	VAV1 PRLR	7.73e-06	4	40	2	11328862
Pubmed	CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase.	MYLK VAV1	7.73e-06	4	40	2	17579061
Pubmed	Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues.	PAX6 PRLR	7.73e-06	4	40	2	19703295
Pubmed	Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.	VAV1 PRLR	1.29e-05	5	40	2	15618286
Pubmed	Cloning, sequencing and expression of the rearranged MOPC 315 VH gene segment.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	2497341
Pubmed	The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	3937730
Pubmed	Model-building studies of antigen-binding sites: the hapten-binding site of mopc-315.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	268248
Pubmed	The structure of the expressible VH gene from a hybridoma producing monoclonal antibodies against porcine transferrin.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	2587273
Pubmed	Amino acid sequence of the precursor region of MOPC-315 mouse immunoglobulin heavy chain.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	414225
Pubmed	A new germline VH36-60 gene is used in the neonatal primary and adult memory response to (T,G)-A--L.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	1683681
Pubmed	Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.	IGHV4-61 IGHV4-34	2.70e-05	7	40	2	4524622
Pubmed	Forebrain gene expression domains and the evolving prosomeric model.	PAX6 SIM1	3.60e-05	8	40	2	12948657
Pubmed	Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube.	PAX6 SIM1	4.62e-05	9	40	2	11566099
Pubmed	Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance.	PAX6 MPPED2	5.77e-05	10	40	2	11889558
Pubmed	Structure and function of immunoglobulin genes and precursors.	IGHV4-61 IGHV4-34	5.77e-05	10	40	2	428562
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	GRIN2D NRXN2	7.05e-05	11	40	2	9647694
Pubmed	A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.	PAX6 SIM1	8.45e-05	12	40	2	21062862
Pubmed	Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.	PAX6 SIM1	8.45e-05	12	40	2	11830575
Pubmed	Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.	PAX6 SIM1	9.98e-05	13	40	2	15576403
Pubmed	V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.	PAX6 SIM1	9.98e-05	13	40	2	24698273
Pubmed	Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve.	PAX6 SIM1	1.16e-04	14	40	2	12571110
Pubmed	Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.	PAX6 SIM1	1.34e-04	15	40	2	12490199
Pubmed	Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.	PAX6 SIM1	1.34e-04	15	40	2	9230312
Pubmed	Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.	PAX6 SIM1	1.53e-04	16	40	2	9655799
Pubmed	Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.	PAX6 SIM1	1.53e-04	16	40	2	10217145
Pubmed	Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.	PAX6 SIM1	1.73e-04	17	40	2	26187199
Pubmed	The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance.	PAX6 SIM1	1.95e-04	18	40	2	21068056
Pubmed	Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.	PAX6 SIM1	2.18e-04	19	40	2	9585504
Pubmed	Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes.	PAX6 MPPED2	2.18e-04	19	40	2	19474196
Pubmed	Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.	PAX6 SIM1	2.94e-04	22	40	2	11955448
Pubmed	Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.	PAX6 SIM1	2.94e-04	22	40	2	15789444
Pubmed	Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.	IGHV4-61 IGHV4-34	2.94e-04	22	40	2	2499654
Pubmed	Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.	PAX6 SIM1	3.21e-04	23	40	2	16357211
Pubmed	Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.	PAX6 SIM1	4.45e-04	27	40	2	15075292
Pubmed	LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.	PAX6 SIM1	4.78e-04	28	40	2	23595746
Pubmed	Role of neuroepithelial Sonic hedgehog in hypothalamic patterning.	PAX6 SIM1	4.78e-04	28	40	2	19474326
Pubmed	Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.	PAX6 SIM1	5.13e-04	29	40	2	30177510
Pubmed	Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.	PAX6 MYLK	5.13e-04	29	40	2	28049658
Pubmed	Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.	PAX6 RP1L1	5.13e-04	29	40	2	30048641
Pubmed	Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.	PAX6 MYLK	5.13e-04	29	40	2	30228103
Pubmed	The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord.	PAX6 SIM1	5.87e-04	31	40	2	26839365
Pubmed	Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor.	PAX6 SIM1	6.26e-04	32	40	2	27806288
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	POGLUT1 PAX6	6.66e-04	33	40	2	15755804
Pubmed	Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.	PAX6 SIM1	7.07e-04	34	40	2	12086465
Pubmed	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.	NRXN2 MPPED2	8.37e-04	37	40	2	22797727
Pubmed	Olig3 regulates early cerebellar development.	PAX6 SIM1	9.79e-04	40	40	2	33591268
Pubmed	The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells.	PAX6 SIM1	9.79e-04	40	40	2	20460368
Cytoband	14q32.33	IGHV4-38-2 IGHV4-61 IGHV4-34 IGHV4-30-4 IGHV4-30-2	1.65e-06	228	40	5	14q32.33
Cytoband	11p13	PAX6 MPPED2	1.11e-03	56	40	2	11p13
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV4-38-2 IGHV4-61 IGHV4-34 IGHV4-30-4 IGHV4-30-2	1.53e-05	187	31	5	349
GeneFamily	Zinc fingers CCCH-type	PRR3 ZC3H3	1.63e-03	35	31	2	73
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYLK WFIKKN1 MYOM3	2.59e-03	161	31	3	593
Disease	cardiovascular age measurement	PKD2L2 ZC3H3	5.76e-04	29	36	2	EFO_0803380
Disease	cataract (implicated_via_orthology)	PAX6 SIPA1L3	9.90e-04	38	36	2	DOID:83 (implicated_via_orthology)
Disease	Liver Cirrhosis, Experimental	NIPAL2 CASP7 ACBD4 VAV1 PRLR	2.36e-03	774	36	5	C0023893
Disease	urolithiasis	NIPAL2 ARSJ	2.70e-03	63	36	2	MONDO_0024647

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPRPGFWDPIGRYKW	ACBD4	56	Q8NC06
IIPRWEFGGALYLGW	CLDN25	156	C9JDP6
PRYLGASGSPRRLWW	PDSS2	11	Q86YH6
DGRVLYWPRGRVWGG	CHDH	116	Q8NE62
WGTRPGWYPGTSVPG	PAX6	156	P26367
PAVWPIYPTGLGRWD	POGLUT1	171	Q8NBL1
GFRIYGAPWTPWFNG	MPPED2	171	Q15777
YGSLRPGWPARGQGW	MYLK	846	Q15746
RSNPRLNGGVWGPWY	ARSJ	541	Q5FYB0
GGYSWSWIRQPPGKG	IGHV4-30-2	51	A0A087WSY4
PGEAWSYFGRPWRNI	BEND2	656	Q8NDZ0
GDYYWSWIRQPPGKG	IGHV4-30-4	51	P0DP06
GSYYWSWIRQPPGKG	IGHV4-61	51	A0A0C4DH41
FGGGPGQWARYARWA	NRXN2	31	Q9P2S2
KRQWVWGPSGYGGIL	PADI3	136	Q9ULW8
VRGFRIYGSPWQPWF	MPPED1	201	O15442
GYYWGWIRQPPGKGL	IGHV4-38-2	51	P0DP08
CYRRPDWGPGVWSQP	OSCAR	101	Q8IYS5
VPGYYSWRSPGRGSW	CASP7	226	P55210
PYWAIYWPGGQALSR	ETFBKMT	91	Q8IXQ9
LYPGPGRVGRFSWAW	PRRT3	661	Q5FWE3
PWSTHRLVPFGWYGG	CH25H	221	O95992
SGYYWSWIRQPPGKG	IGHV4-34	56	P06331
WLYREPRGGGARPWL	PLEKHH3	101	Q7Z736
PRPYFKSVLWWGGVL	NIPAL2	81	Q9H841
GPRSSPYGRGWWGVN	PRR3	91	P79522
PYGRGWWGVNAEPPF	PRR3	96	P79522
GGRPPYRSNAPWQWS	SIPA1L3	1071	O60292
RYFLGTPQAGREPWW	SIM1	476	P81133
LWGRLSLGYYRGFWP	SLC25A53	166	Q5H9E4
PGSPWWRSKGYRCIG	ZC3H3	591	Q8IXZ2
GYPWGFSEPGVWGPR	RP1L1	371	Q8IWN7
WRGEIYGRVGWFPAN	VAV1	821	P15498
CWWRPGTDGGLPTNY	PRLR	46	P16471
PWHWGFLGVYRNGGY	PKD2L2	186	Q9NZM6
GPCRGWEPRWAYSPL	WFIKKN1	366	Q96NZ8
PSHWSPWRRPYGLGR	USP31	686	Q70CQ4
GVPTFRGAGGYWRKW	SIRT5	66	Q9NXA8
GGKGPIRGWKSRWFF	TBC1D2	56	Q9BYX2
RELCYGRGPWFWIPL	MYOM3	146	Q5VTT5
WRAGSWDYLPPRSGP	GRIN2D	1161	O15399