Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmaturation of SSU-rRNA

BYSL TSR3 RPP40

5.61e-0555283GO:0030490
DomainMYTH4

PLEKHH1 PLEKHH2 MYO7A

2.81e-079293PS51016
DomainMyTH4_dom

PLEKHH1 PLEKHH2 MYO7A

2.81e-079293IPR000857
DomainMyTH4

PLEKHH1 PLEKHH2 MYO7A

2.81e-079293SM00139
DomainMyTH4

PLEKHH1 PLEKHH2 MYO7A

2.81e-079293PF00784
DomainFERM_M

PLEKHH1 PLEKHH2 MYO7A

4.88e-0546293PF00373
DomainFERM_central

PLEKHH1 PLEKHH2 MYO7A

5.91e-0549293IPR019748
DomainFERM_domain

PLEKHH1 PLEKHH2 MYO7A

5.91e-0549293IPR000299
Domain-

PLEKHH1 PLEKHH2 MYO7A

5.91e-05492931.20.80.10
DomainFERM_1

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293PS00660
DomainFERM_2

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293PS00661
DomainBand_41_domain

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293IPR019749
DomainB41

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293IPR014352
DomainFERM_3

PLEKHH1 PLEKHH2 MYO7A

6.28e-0550293PS50057
DomainUSP_CS

USP26 USP13

4.70e-0366292IPR018200
DomainUSP_1

USP26 USP13

5.27e-0370292PS00972
DomainUCH

USP26 USP13

5.41e-0371292PF00443
DomainUSP_2

USP26 USP13

5.41e-0371292PS00973
DomainUSP_3

USP26 USP13

5.56e-0372292PS50235
DomainUSP_dom

USP26 USP13

5.56e-0372292IPR028889
DomainPeptidase_C19_UCH

USP26 USP13

5.56e-0372292IPR001394
Pubmed

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis.

IL13RA2 MARVELD2

6.71e-07229228612843
Pubmed

USP51 promotes deubiquitination and stabilization of ZEB1.

USP26 USP13

5.21e-051329229119051
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

PLEKHH1 TSR3 TRAPPC5 ZMYND8

4.36e-044322947671812
CytobandEnsembl 112 genes in cytogenetic band chr20q13

HELZ2 KCNB1 ZMYND8

2.36e-03422293chr20q13
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PLEKHH1 PLEKHH2 MYO7A

2.95e-05502231293
GeneFamilyUbiquitin specific peptidases

USP26 USP13

2.09e-0356222366
GeneFamilyActins|Deafness associated genes

MARVELD2 MYO7A

8.24e-031132221152
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHH1 PLEKHH2

2.57e-02206222682
ToppCellBAL-Mild|BAL / Compartment, Disease Groups and Clusters

HELZ2 DDX60 TRAPPC5 APOBEC3F

7.02e-061922941a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO7A TMEM132D EXPH5

9.52e-05137293761cc0e2b4971e98f6d0691d4575b5cd208b602d
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIGB RPP40

1.29e-0426292e2db677bc0f2011883c8b44058276ecf879d4303
ToppCellPBMC-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

HELZ2 PLEKHH1 DDX60

1.40e-041562939b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HELZ2 DDX60 CD109

1.74e-0416829355c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASD1 MYO7A EXPH5

1.86e-04172293b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASD1 MYO7A EXPH5

1.86e-041722932f1673fcb2356684d60871debb0f159aec553a1c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHH1 PLEKHH2 TMEM132D

1.96e-04175293284fdc7a9d303636a637041846850d19d114861a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL13RA2 RPP40 CD109

2.00e-0417629364e426f5e84884ce2c29acf6f4b958962a63927f
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HELZ2 IL13RA2 KRTDAP

2.03e-0417729330f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

USP13 GPRC5B CD109

2.10e-04179293754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8 EXPH5 DDX60

2.13e-041802935b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NAT8 EXPH5 DDX60

2.13e-04180293d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

USP13 GPRC5B CD109

2.13e-04180293493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHH1 PLEKHH2 TMEM132D

2.17e-041812936a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.24e-04183293c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HELZ2 PLEKHH2 APOBEC3F

2.35e-0418629377bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

HELZ2 PLEKHH2 APOBEC3F

2.35e-0418629313bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellNeuronal_cells-Schwann_cells|World / Lineage and Cell class

PLEKHH1 HDAC11 GPRC5B

2.46e-04189293371cdc92549269e45c23c5a5b3cae9c5d35ee217
ToppCellNeuronal_cells|World / Lineage and Cell class

PLEKHH1 HDAC11 GPRC5B

2.46e-041892933948775a0ebd4b32c1623d5487f5581e6e2934d7
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PIGB ZMYND8 CD109

2.50e-0419029363018acb7ad80415e861643162abdc2e55968ee4
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.50e-04190293c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.54e-0419129372dbd2e0fabfca8d6f604df35277d3574739a0b3
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

HELZ2 DDX60 APOBEC3F

2.54e-041912932da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.54e-0419129363aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.58e-04192293c15841f35e24d6ef6ce2a9a6dc62e66efdc3d9d5
ToppCellPCW_05-06-Epithelial-Epithelial_airway|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.62e-04193293af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCellPCW_05-06-Epithelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.66e-0419429347a1369c22fcbfe00b08376eb610a61c355548db
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.66e-04194293f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.66e-04194293cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MARVELD2 TMEM132D EXPH5

2.66e-04194293b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL13RA2 GPRC5B CD109

2.66e-04194293660535b492445063d965095a50e1e299ce04c50a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.74e-0419629377feb22fd0b0b1df03375da472134412e9e69c90
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.78e-04197293032ccc91e604113da9bc34a6f9ddb1d45dea1892
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHH1 HDAC11 GPRC5B

2.82e-04198293a183afe4c2034323f77abfa080f359d67da35e8f
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.82e-04198293bdabdb11217ea16e5863aa6bfb0f04d48b17f81e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHH1 HDAC11 GPRC5B

2.90e-04200293e5b4821fff40566c4a7dc3f74a14e27eb06b165d
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.90e-042002930bfd41c12887479ceb62c3db0a3c3ba5007eb62b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.90e-04200293159377d904394d91e09913131e9a93e08189955a
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLEKHH1 HDAC11 GPRC5B

2.90e-04200293d30316836494f33ca46d4e415fd2ed179e9cb5ee
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

HELZ2 DDX60 CD109

2.90e-04200293be55cef682ba87250dad97689332c8820b3a7420
Diseasefactor VII activating protease measurement

HELZ2 ST8SIA3 ZMYND8

1.74e-0555273EFO_0009368
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MARVELD2 MYO7A

1.00e-0351272cv:CN043650
Diseaseserum alanine aminotransferase measurement, response to combination chemotherapy

KCNB1 TMEM132D

1.93e-0371272EFO_0004735, EFO_0007965
DiseaseNonsyndromic genetic hearing loss

MARVELD2 MYO7A

2.20e-0376272cv:C5680182
DiseaseNonsyndromic Deafness

MARVELD2 MYO7A

2.50e-0381272C3711374
DiseaseHIV-1 infection

USP26 ST8SIA3

3.63e-0398272EFO_0000180
Diseasehearing impairment

MARVELD2 MYO7A

3.63e-0398272C1384666

Protein segments in the cluster

PeptideGeneStartEntry
YTKWDKLKLFFELFP

USP26

276

Q9BXU7
PFDAGKWGKVINFLK

HDAC11

36

Q96DB2
LSKKTLLRFWLPFGF

IL13RA2

336

Q14627
KVDKWSRFLFPLAFG

GABRQ

606

Q9UN88
FKLSALAPLFGSLKW

DDX60

221

Q8IY21
KLPFLNWDAFPKLKG

KRTDAP

76

P60985
WKPSFLKNPGFLKDD

EXPH5

1911

Q8NEV8
TVARKWPFFGAKLFL

PLEKHH2

1341

Q8IVE3
WPFFGAKLFLAKPIT

PLEKHH2

1346

Q8IVE3
GLALFTLCGKFKRWK

GPRC5B

216

Q9NZH0
FKPWKGLKYNFLFLD

APOBEC3F

351

Q8IUX4
LTFLPLSFWGKKKNI

CD109

266

Q6YHK3
LRFLSSPKKWKFFKG

KCNB1

246

Q14721
KIFSLWPLSKCFELK

CASD1

576

Q96PB1
FVPDSWKNFFRGKKK

MARVELD2

81

Q8N4S9
PTKSWLKKFLGFVVD

HELZ2

2576

Q9BYK8
VWAKLKGFPFWPAKA

ZMYND8

281

Q9ULU4
LKKALFKPGAWFKGI

BYSL

276

Q13895
SWSFKEKKPLKFDFL

RPP40

166

O75818
LKTWKKPALSFLFLS

PIGB

381

Q92521
WLKRGLKFLKGFLTE

PLEKHA8P1

291

O95397
PFGFTNKFSLNWKLK

TMEM132D

116

Q14C87
GFPKAAKLFLLKWSF

RFX1

841

P22670
KKLDGAILWIPAFFF

ST8SIA3

236

O43173
LTVARKWPFFGAKLF

PLEKHH1

1216

Q9ULM0
KKFTFGLDWVPKKFD

USP13

586

Q92995
AVILLRKFKWGKGFL

TSR3

181

Q9UJK0
LLFVKGAVWKALFGK

TRAPPC5

86

Q8IUR0
AKLAFLKLIFKWPTF

MYO7A

2096

Q13402
LKLIFKWPTFGSAFF

MYO7A

2101

Q13402
FSISLFPALWFLAKK

NAT8

66

Q9UHE5