Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoAbnormal vitreous humor morphology

LRP5 CRPPA PRPF8

4.53e-054983HP:0004327
Domain-

LRP5 NHLRC2

1.55e-03392822.120.10.30
Domain6-blade_b-propeller_TolB-like

LRP5 NHLRC2

2.15e-0346282IPR011042
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

USP36 UTP6 FIP1L1 TMEM214 TFB2M UTP3 PRPF8

6.19e-0841031726949251
Pubmed

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.

PRPF8 RPAP3

2.15e-05831226711270
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

USP36 UTP6 FIP1L1 PRPF8

8.07e-0525931430404004
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

USP36 HMBOX1 FIP1L1 TMEM214 BRD3 PRPF8 TASOR

1.17e-04129431730804502
Pubmed

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.

FIP1L1 TFB2M PRPF8

2.08e-0412931328973437
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

USP36 UTP6 UTP3 TASOR

2.09e-0433231425693804
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

FIP1L1 UTP3 TASOR

3.11e-0414831332538781
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

FIP1L1 PRPF8 RPAP3

3.49e-0415431316055720
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

FIP1L1 BRD3 TFB2M ENDOG

4.24e-0440031435013556
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

FIP1L1 NHLRC2 RPAP3 TASOR ACBD3

4.42e-0473331534672954
Pubmed

A neurogenomics approach to gene expression analysis in the developing brain.

ROGDI TASOR ENC1

4.66e-0417031315582152
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TMEM214 TFB2M PRPF8 TASOR ACBD3

5.03e-0475431535906200
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

FIP1L1 TASOR STXBP5

5.51e-0418031335198878
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

FIP1L1 PRPF8 ACBD3

6.25e-0418831329721183
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

FIP1L1 PRPF8

6.79e-044331226487511
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

UTP6 BRD3 PRPF8

6.95e-0419531319454010
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

FIP1L1 BRD3 UTP3 PRPF8 TASOR

8.50e-0484731535850772
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

USP36 UTP6 UTP3 PRPF8

8.59e-0448331436912080
InteractionMKI67 interactions

USP36 UTP6 FIP1L1 TMEM214 BRD3 TFB2M UTP3 PRPF8

2.58e-06648298int:MKI67
InteractionCIT interactions

UTP6 FIP1L1 TMEM214 BRD3 TFB2M ROGDI UTP3 PRPF8 RPAP3 STXBP5 PRPH

2.65e-0614502911int:CIT
InteractionEMG1 interactions

USP36 BRD3 PRPF8 TASOR

2.00e-05113294int:EMG1
InteractionIGKC interactions

USP36 NHLRC2 PRPF8 ENC1

3.46e-05130294int:IGKC
InteractionKRT84 interactions

USP36 NHLRC2 PRPH

4.72e-0549293int:KRT84
InteractionFSAF1 interactions

USP36 UTP3 PRPF8

8.68e-0560293int:FSAF1
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV6-1 IGHV2-70

8.92e-03187142349
CoexpressionGSE3982_CTRL_VS_LPS_1H_NEUTROPHIL_UP

BRD3 ROGDI TASOR ACBD3 PCIF1

2.86e-06198305M5371
CoexpressionGSE13229_MATURE_VS_INTMATURE_NKCELL_DN

BRD3 PRPF8 ACBD3 MDM1

7.42e-05198304M3216
CoexpressionGSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_UP

TFB2M ENDOG STXBP5 MDM1

7.57e-05199304M4271
CoexpressionGSE12366_PLASMA_CELL_VS_MEMORY_BCELL_DN

UTP6 BRD3 UTP3 GMIP

7.57e-05199304M3177
CoexpressionGSE369_IFNG_KO_VS_WT_LIVER_DN

USP36 TFB2M ENDOG RPAP3

7.72e-05200304M5972
CoexpressionGSE8835_CD4_VS_CD8_TCELL_UP

LRP5 ROGDI UTP3 PRPF8

7.72e-05200304M6254
CoexpressionAtlasratio_EmbryoidBody-blastocyst_vs_EmbryoidBody-fibro_top-relative-expression-ranked_2500_k-means-cluster#1

USP36 HMBOX1 FIP1L1 MANEA TFB2M UTP3 RPAP3 MDM1 PCIF1

6.06e-06993309ratio_EB-blastocyst_vs_EB-fibro_2500_K1
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ROGDI PAK5 ENC1 DOP1B

1.09e-052003141decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FIP1L1 MANEA GMIP

1.59e-041523130652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP5 MANEA IGHV6-1

1.68e-04155313881422c57d230c0e2e5f9098ab888caa94ca61aa
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-Plasma_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP5 MANEA IGHV6-1

1.91e-041623138278dccdb139396ede34b83b02ebce837f2489d6
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP5 ROGDI MDM1

2.24e-04171313355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MANEA IGHV6-1 IGHV2-70

2.61e-04180313588461d603dafa74e274a1dea021fd568e7f7875
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAK5 ENC1 PRPH

2.69e-04182313be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCellmild_COVID-19-Plasmablast|mild_COVID-19 / disease group, cell group and cell class (v2)

MANEA IGHV6-1 IGHV2-70

2.87e-04186313a639d2183b85b1be6e6da2b2e112aec5149d5bcd
ToppCellIPF-Lymphoid-B_Plasma|Lymphoid / Disease state, Lineage and Cell class

MANEA IGHV6-1 IGHV2-70

2.87e-04186313f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MANEA TMEM214 IGHV6-1

3.05e-0419031384eb7761f537d270673909a71d4f122e826769d5
ToppCellCOVID-19_Moderate-Plasmablast|World / disease group, cell group and cell class

MANEA TMEM214 IGHV6-1

3.10e-04191313bb28703020c5296b65527094d2e5924348275e58
ToppCellsevere-Lymphocytic-Plasmablast|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

MANEA TMEM214 IGHV6-1

3.10e-0419131373660d762c9d451980c21adc426db6670bcaf37f
ToppCellCOVID-19_Severe-Lymphoid_P-Plasmablast|COVID-19_Severe / Disease group, lineage and cell class

MANEA TMEM214 IGHV6-1

3.15e-0419231390af8dad4e6f80b5ecd62027deeb2e4cea6b24bb
ToppCellCOVID-19_Severe-Lymphoid_P|COVID-19_Severe / Disease group, lineage and cell class

MANEA TMEM214 IGHV6-1

3.15e-041923133d0240491296757b3125f6e861bbaca06bbc5068
ToppCellCOVID-19_Moderate-Plasmablast|COVID-19_Moderate / disease group, cell group and cell class

MANEA TMEM214 IGHV6-1

3.15e-0419231325c6c7a244190f82c7feab874bdec12490b7de4d
ToppCellCOVID-19_Severe-Plasmablast|World / disease group, cell group and cell class

MANEA TMEM214 IGHV6-1

3.15e-04192313a333053fe2bd206c32790916bfc5fce904ab7f57
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAK5 ENC1 PRPH

3.20e-04193313a189d46c39067b717509cd144e0225cc93d7731d
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MANEA TMEM214 IGHV6-1

3.20e-04193313ce3873ece35fd2155ea235cb3c8bcd235cc0ebde
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MANEA TMEM214 IGHV6-1

3.20e-04193313227d82059a9f99937e0188ff57f2d0e485ebfe69
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MANEA TMEM214 IGHV6-1

3.20e-041933138f57b0473a2c2c07f83e5fe70f16862b1bb3b514
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MANEA TMEM214 IGHV6-1

3.20e-0419331338bb14df7f05c29565a1c7f175fafe636e543bf8
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MANEA TMEM214 IGHV6-1

3.20e-041933133ba6d44248690b80f4caf791d463e60f1ab816c4
ToppCellsevere-Lymphocytic-Plasmablast|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

MANEA TMEM214 IGHV6-1

3.30e-0419531343ff1eed563c647bc5b7b06ffe136210653c3a83
ToppCellBiopsy_Other_PF-Immune-Plasma_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

MANEA IGHV6-1 IGHV2-70

3.30e-04195313d0305c6a68c9e361507b04db94f86873085d49b3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn|World / Primary Cells by Cluster

PAK5 ENC1 DOP1B

3.34e-041963139401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAK5 ENC1 PRPH

3.34e-0419631336b4f08fc038dfde6343ff0869e1a027d882adb5
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B-Plasmablast|Influenza_Severe / Disease, condition lineage and cell class

LRP5 IGHV6-1 IGHV2-70

3.40e-041973139108edafbf5744ed65f556bcbbf819a9b71176a9
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B-Plasmablast|COVID-19_Severe / Disease, condition lineage and cell class

MANEA TMEM214 IGHV6-1

3.50e-04199313e6422b65e22e5aa8dfaebdae5be76dd78b978604
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 ENC1 DOP1B

3.50e-04199313a255484ba77bd2741a541da278efc8cf4abbe570
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-Neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ROGDI ENC1 DOP1B

3.50e-04199313ae575ed7582f2a4218f6cbcbf5f7f0ce7a5bc26b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 ENC1 DOP1B

3.55e-0420031384e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 ENC1 DOP1B

3.55e-04200313306926cb7a847871641f02e03d52dc56fd55711c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PAK5 ENC1 DOP1B

3.55e-042003135b3df61ff421846ef4cabf1bd5355534c8b95509
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

CRPPA NHLRC2 PCIF1

1.53e-03225303EFO_0008317, EFO_0020947
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

CRPPA NHLRC2 PCIF1

2.40e-03264303EFO_0008317, EFO_0020944
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

NHLRC2 TASOR PCIF1

3.16e-03291303EFO_0008317, EFO_0020946
Diseasereticulocyte measurement

LRP5 BRD3 PRPF8 ENC1 PCIF1

3.89e-031053305EFO_0010700
Diseasetriglyceride measurement, alcohol drinking

GMIP PCIF1

4.56e-0399302EFO_0004329, EFO_0004530
Diseasetriglyceride measurement, alcohol consumption measurement

GMIP PCIF1

4.74e-03101302EFO_0004530, EFO_0007878

Protein segments in the cluster

PeptideGeneStartEntry
IKKRLENNYYWSASE

BRD3

86

Q15059
LWKVTYKRDLYAAES

CRPPA

261

A4D126
EYSDLKWEYQRASSS

PAK5

211

Q9P286
AALEYAKTWSRYAKE

GMIP

96

Q9P107
SSLSGYAYTKRAWRK

DOP1B

1956

Q9Y3R5
RWKASKYYLDLNSDS

LRP5

1556

O75197
SDLSEQKKRAFYRWY

HMBOX1

211

Q6NT76
WYKSKYADLSDAANR

PRPH

286

P41219
DTSKQWDYYARREKD

FIP1L1

446

Q6UN15
YQRNFLWKKSYLSES

MDM1

11

Q8TC05
LKFDNSYSLWRSKSV

ACBD3

506

Q9H3P7
LIDWDDDKYYSTSLK

IGHV2-70

71

P01814
RSKWYNDYAVSVKSR

IGHV6-1

76

A0A0B4J1U7
TWDKKRNLLYVADSY

NHLRC2

481

Q8NBF2
KWSEKYSKERATYAL

MANEA

441

Q5SRI9
KLWLLYRYSCIDDSA

PCIF1

446

Q9H4Z3
YDAEEREKTYRKWSS

ADPRHL1

251

Q8NDY3
YESAINWISYDLKKR

ENC1

211

O14682
SLSWGQRKKLYYDTD

UTP3

126

Q9NQZ2
ADSVTLKNKYLDWAY

UTP6

471

Q9NYH9
LKDKISVFSSYWSYR

ROGDI

271

Q9GZN7
WNNLEKYSRSLTRSY

ENDOG

176

Q14249
KRALWKLAYDLYSCT

TFB2M

201

Q9H5Q4
VLWDLKSKKADYRYT

STXBP5

221

Q5T5C0
NTDRNIDKYNYTLWK

TASOR

346

Q9UK61
DKYTSTSYNDSAWRK

C12orf50

376

Q8NA57
LFNLYDDWLKTISSY

PRPF8

1916

Q6P2Q9
TKNRIKSYDYEAWAK

RPAP3

81

Q9H6T3
WLKDLASYLNYKLQA

TMEM214

141

Q6NUQ4
KYSSDKAYGRKVLTW

USP36

1031

Q9P275
KNLYSSNLYKEAWDR

NEB

4696

P20929