Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear vitamin D receptor binding	NCOA6 TOB2 MED16 MED14	1.03e-06	18	88	4	GO:0042809
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	MKKS SETD1A NCOA6 TOB2 MED16 MED14 APEX1 KDM5D PRAME TP53BP1	1.50e-05	417	88	10	GO:0061629
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA6 TOB2 MED16 MED14 KDM5D PRAME	1.79e-04	187	88	6	GO:0016922
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	MKKS SETD1A NCOA6 TOB2 MED16 MED14 APEX1 KDM5D PRAME TP53BP1	2.40e-04	582	88	10	GO:0140297
GeneOntologyMolecularFunction	ubiquitin-modified histone reader activity	CCDC38 TP53BP1	3.97e-04	7	88	2	GO:0061649
GeneOntologyMolecularFunction	transcription factor binding	MKKS SETD1A NCOA6 TOB2 MED16 ZNF618 MED14 APEX1 KDM5D PRAME TP53BP1	4.64e-04	753	88	11	GO:0008134
GeneOntologyMolecularFunction	chromatin-protein adaptor activity	NCOA6 CCDC38 TP53BP1	7.81e-04	41	88	3	GO:0140463
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	IL1RAPL2 TLR1 APEX1	7.81e-04	41	88	3	GO:0016799
GeneOntologyBiologicalProcess	spermatid differentiation	MKKS DNHD1 FSIP2 SUN5 NXF2 YTHDC2 MAST2 CCDC38	1.96e-05	272	87	8	GO:0048515
GeneOntologyBiologicalProcess	gamete generation	MKKS DNHD1 FSIP2 SPATA31D1 TOB2 DMXL2 SUN5 MARF1 NXF2 YTHDC2 MAST2 ACE CCDC38 FANCA	5.90e-05	982	87	14	GO:0007276
GeneOntologyBiologicalProcess	modulation by host of viral process	PIK3C2G DDX56 YTHDC2 FBXL2	6.85e-05	52	87	4	GO:0044788
GeneOntologyBiologicalProcess	male gamete generation	MKKS DNHD1 FSIP2 SPATA31D1 DMXL2 SUN5 NXF2 YTHDC2 MAST2 ACE CCDC38 FANCA	8.28e-05	762	87	12	GO:0048232
GeneOntologyBiologicalProcess	sexual reproduction	MKKS DNHD1 FSIP2 SPATA31D1 TOB2 DMXL2 USP17L2 NUMA1 SUN5 MARF1 NXF2 YTHDC2 MAST2 ACE CCDC38 FANCA	1.06e-04	1312	87	16	GO:0019953
GeneOntologyBiologicalProcess	spermatid development	MKKS DNHD1 FSIP2 SUN5 NXF2 YTHDC2 CCDC38	1.21e-04	262	87	7	GO:0007286
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	MKKS DNHD1 FSIP2 SPATA31D1 TOB2 DMXL2 SUN5 MARF1 NXF2 YTHDC2 MAPK1 MAST2 ACE CCDC38 FANCA	1.30e-04	1194	87	15	GO:0048609
GeneOntologyCellularComponent	extracellular matrix of synaptic cleft	LAMA5 TNR	5.36e-05	3	89	2	GO:0098965
GeneOntologyCellularComponent	sperm flagellum	DNHD1 FSIP2 VPS13A NXF2 ACE CCDC38	3.08e-04	214	89	6	GO:0036126
GeneOntologyCellularComponent	neuronal dense core vesicle	DMXL2 VPS13A PLCB2	4.81e-04	36	89	3	GO:0098992
GeneOntologyCellularComponent	9+2 motile cilium	DNHD1 FSIP2 VPS13A NXF2 ACE CCDC38	5.41e-04	238	89	6	GO:0097729
GeneOntologyCellularComponent	motile cilium	MKKS DNHD1 FSIP2 VPS13A NXF2 ACE CCDC38	8.03e-04	355	89	7	GO:0031514
GeneOntologyCellularComponent	cell body fiber	HTR2A SACS	9.62e-04	11	89	2	GO:0070852
Domain	Leu-rich_rpt	CEP78 CARMIL3 TLR1 NXF2 FLRT2 LRRK1 TLR9 SLITRK6 FBXL2 PRAME TLR8	7.40e-08	271	90	11	IPR001611
Domain	-	CEP78 CARMIL3 TLR1 NXF2 FLRT2 LRRK1 TLR9 SLITRK6 FBXL2 PRAME TLR8	4.05e-07	321	90	11	3.80.10.10
Domain	L_dom-like	CEP78 CARMIL3 TLR1 NXF2 FLRT2 LRRK1 TLR9 SLITRK6 FBXL2 PRAME TLR8	5.01e-07	328	90	11	IPR032675
Domain	TIR	IL1RAPL2 TLR1 TLR9 TLR8	2.83e-06	21	90	4	SM00255
Domain	TIR	IL1RAPL2 TLR1 TLR9 TLR8	3.45e-06	22	90	4	PF01582
Domain	-	IL1RAPL2 TLR1 TLR9 TLR8	4.16e-06	23	90	4	3.40.50.10140
Domain	TIR	IL1RAPL2 TLR1 TLR9 TLR8	4.98e-06	24	90	4	PS50104
Domain	TIR_dom	IL1RAPL2 TLR1 TLR9 TLR8	5.90e-06	25	90	4	IPR000157
Domain	LRR_1	TLR1 FLRT2 LRRK1 TLR9 SLITRK6 FBXL2 PRAME TLR8	1.07e-05	219	90	8	PF00560
Domain	ARM-type_fold	USP34 URB1 PACRGL GBF1 PIK3C2G UBR4 EIF3K UNC79 KPNA1	3.73e-05	339	90	9	IPR016024
Domain	LRR_6	CEP78 CARMIL3 TLR9 FBXL2	1.43e-04	55	90	4	PF13516
Domain	Leu-rich_rpt_typical-subtyp	TLR1 FLRT2 LRRK1 TLR9 SLITRK6 TLR8	2.14e-04	177	90	6	IPR003591
Domain	LRR_TYP	TLR1 FLRT2 LRRK1 TLR9 SLITRK6 TLR8	2.14e-04	177	90	6	SM00369
Domain	LRR	TLR1 NXF2 LRRK1 TLR9 SLITRK6 TLR8	4.24e-04	201	90	6	PS51450
Domain	LRRCT	TLR1 FLRT2 SLITRK6	4.85e-04	32	90	3	PF01463
Domain	Cys-rich_flank_reg_C	TLR1 FLRT2 SLITRK6 TLR8	9.39e-04	90	90	4	IPR000483
Domain	LRRCT	TLR1 FLRT2 SLITRK6 TLR8	9.39e-04	90	90	4	SM00082
Domain	LRR_8	TLR1 FLRT2 TLR9 SLITRK6 TLR8	1.42e-03	171	90	5	PF13855
Domain	Quino_amine_DH_bsu	WDR36 LRRK1	4.98e-03	22	90	2	IPR011044
Domain	-	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	6.98e-03	248	90	5	1.25.40.20
Domain	ANK	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	7.33e-03	251	90	5	SM00248
Domain	ANK_REPEAT	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	7.57e-03	253	90	5	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	7.70e-03	254	90	5	IPR020683
Domain	ANK_REP_REGION	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	7.70e-03	254	90	5	PS50297
Domain	Ankyrin_rpt	ANKRD36B NUDT12 ANKRD30A YTHDC2 LRRK1	8.73e-03	262	90	5	IPR002110
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88	TLR1 MAPK1 TLR9 TLR8	1.11e-05	31	64	4	M39573
Pathway	WP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY	TLR1 TLR9 TLR8	6.94e-05	18	64	3	M39478
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 USP34 SETD1A NCOA6 URB1 GBF1 SSH1 UBR4 MED14 LAMA5 DDX56 TBC1D25 LRRK1 MAST2 PLEKHG5 FANCA	3.17e-08	1105	92	16	35748872
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1A WDR36 MED16 NUMA1 MED14 DDX56 YTHDC2 NUP93 TP53BP1 KPNA1	2.71e-07	440	92	10	34244565
Pubmed	The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.	TLR1 TLR9 TLR8	6.22e-07	7	92	3	19924287
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR1 TLR9 TLR8	9.94e-07	8	92	3	20100933
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	CDKL5 L3MBTL1 SACS TNR	1.37e-06	31	92	4	27798109
Pubmed	Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation.	TLR1 TLR9 TLR8	1.49e-06	9	92	3	20977567
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR1 TLR9 TLR8	1.49e-06	9	92	3	24091496
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP34 ROBO4 GBF1 SSH1 IL1RAPL2 NXF2 APEX1 LRRK1 MAST2	1.80e-06	420	92	9	28065597
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR1 TLR9 TLR8	2.12e-06	10	92	3	20227302
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR1 TLR9 TLR8	2.12e-06	10	92	3	9435236
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR1 TLR9 TLR8	2.12e-06	10	92	3	18686608
Pubmed	Toll-like receptors.	TLR1 TLR9 TLR8	2.12e-06	10	92	3	11782555
Pubmed	Toll-like receptors.	TLR1 TLR9 TLR8	2.91e-06	11	92	3	18394314
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TLR1 TLR9 TLR8	6.38e-06	14	92	3	34206257
Pubmed	Mast cells as sensors of cell injury through IL-33 recognition.	TLR1 TLR9 TLR8	6.38e-06	14	92	3	21239713
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR1 TLR9 TLR8	6.38e-06	14	92	3	20595247
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HIVEP3 DMXL2 GBF1 SSH1 SACS ZNF618 TLR1 FLRT2 TRAPPC8	6.59e-06	493	92	9	15368895
Pubmed	Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever.	TLR9 TLR8	6.92e-06	2	92	2	20674764
Pubmed	The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.	NUMA1 TP53BP1	6.92e-06	2	92	2	30812030
Pubmed	Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.	TLR9 TLR8	6.92e-06	2	92	2	30424735
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 FRY SENP1 SSH1 ZNF618 UBR4 NUMA1 MAPK1 TNR UNC79 TP53BP1 KPNA1	9.01e-06	963	92	12	28671696
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GMPS USP34 URB1 WDR36 UBR4 NUMA1 DDX56 YTHDC2 NUP93 TP53BP1	9.20e-06	653	92	10	22586326
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SETD1A NCOA6 SACS KPNA1	9.62e-06	50	92	4	37974198
Pubmed	Expression of Toll-like receptors in the developing brain.	TLR1 TLR9 TLR8	9.78e-06	16	92	3	22666391
Pubmed	Natural selection in the TLR-related genes in the course of primate evolution.	TLR1 TLR9 TLR8	9.78e-06	16	92	3	18810425
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	HTR2A TLR1 TLR9 MMP8 ACE TNR	1.05e-05	186	92	6	20673868
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	HTR2A TLR1 TLR9 MMP8 ACE TNR	1.05e-05	186	92	6	20452482
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	SETD1A NCOA6 TP53BP1	1.42e-05	18	92	3	17500065
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	SETD1A NCOA6 MED14 TP53BP1 KPNA1	1.67e-05	119	92	5	23508102
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	TLR1 TLR9 TLR8	1.68e-05	19	92	3	19505919
Pubmed	Dual or triple activation of TLR7, TLR8, and/or TLR9 by single-stranded oligoribonucleotides.	TLR9 TLR8	2.07e-05	3	92	2	22196370
Pubmed	Toll-like receptors as adjuvant receptors.	TLR9 TLR8	2.07e-05	3	92	2	11909637
Pubmed	Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus.	TLR9 TLR8	2.07e-05	3	92	2	24919757
Pubmed	Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques.	TLR9 TLR8	2.07e-05	3	92	2	24390332
Pubmed	Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy.	TLR9 TLR8	2.07e-05	3	92	2	23221735
Pubmed	Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA.	TLR9 TLR8	2.07e-05	3	92	2	20308556
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR8	2.07e-05	3	92	2	11607792
Pubmed	TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice.	TLR9 TLR8	2.07e-05	3	92	2	24474776
Pubmed	Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair.	SENP1 TP53BP1	2.07e-05	3	92	2	28576968
Pubmed	Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.	TLR9 TLR8	2.07e-05	3	92	2	21977996
Pubmed	Functional expression of 5-HT2A receptor in osteoblastic MC3T3-E1 cells.	HTR2A MAPK1	2.07e-05	3	92	2	20399747
Pubmed	Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation.	TLR9 TLR8	2.07e-05	3	92	2	24386404
Pubmed	Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9.	TLR9 TLR8	2.07e-05	3	92	2	18406377
Pubmed	Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.	TLR9 TLR8	2.07e-05	3	92	2	26762473
Pubmed	Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.	TLR9 TLR8	2.07e-05	3	92	2	17932028
Pubmed	Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).	APEX1 KPNA1	2.07e-05	3	92	2	15942031
Pubmed	Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer.	NUMA1 TP53BP1	2.07e-05	3	92	2	34165167
Pubmed	Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.	TLR9 TLR8	2.07e-05	3	92	2	28062211
Pubmed	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.	TLR9 TLR8	2.07e-05	3	92	2	22768144
Pubmed	The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.	TLR9 TLR8	2.07e-05	3	92	2	17040905
Pubmed	Expression of Toll-like receptors 7, 8, and 9 in primary Sjögren's syndrome.	TLR9 TLR8	2.07e-05	3	92	2	20399690
Pubmed	TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil.	TLR9 TLR8	2.07e-05	3	92	2	22065095
Pubmed	Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.	TLR9 TLR8	2.07e-05	3	92	2	11022120
Pubmed	A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis.	TLR9 TLR8	2.07e-05	3	92	2	23370539
Pubmed	B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.	TLR1 TLR9	2.07e-05	3	92	2	25536171
Pubmed	Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.	TLR9 MAP3K2	2.07e-05	3	92	2	25981615
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	GMPS NUDT12 FRY URB1 CCDC73 ZNF618 UBR4 VPS13A TNR FANCA	2.57e-05	736	92	10	29676528
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	TLR1 TLR9 TLR8	2.66e-05	22	92	3	31729371
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	URB1 WDR36 NUMA1 EIF3K DDX56 YTHDC2 NUP93	2.97e-05	332	92	7	25693804
Pubmed	Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.	PIK3C2G MAPK1 TLR9	3.05e-05	23	92	3	19047410
Pubmed	The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.	TLR1 TLR9 ACE	3.05e-05	23	92	3	20207250
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 CASP8AP2 NCOA6 DMXL2 URB1 GBF1	3.08e-05	225	92	6	12168954
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SETD1A NCOA6 SENP1 UBR4 MED14 DDX56 TP53BP1	3.51e-05	341	92	7	32971831
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETD1A WDR36 SSH1 NUMA1 EIF3K NUP93 UNC79 TP53BP1	3.56e-05	469	92	8	27634302
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	GBF1 WDR36 SSH1 YTHDC2 MAST2 DENND4C	3.65e-05	232	92	6	25515538
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GMPS DNHD1 NCOA6 SENP1 NUMA1 MAST2	3.83e-05	234	92	6	36243803
Pubmed	Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells.	TLR1 TLR9	4.14e-05	4	92	2	18981243
Pubmed	Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.	TLR9 TLR8	4.14e-05	4	92	2	21515789
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR1 TLR8	4.14e-05	4	92	2	25253287
Pubmed	Regulation and signal transduction of toll-like receptors in human chorioncarcinoma cell lines.	TLR1 TLR9	4.14e-05	4	92	2	15790341
Pubmed	Targeting skeletal endothelium to ameliorate bone loss.	HIVEP3 ROBO4	4.14e-05	4	92	2	29785024
Pubmed	Allele and genotype frequencies of polymorphic DCP1, CETP, ADRB2, and HTR2A in the Egyptian population.	HTR2A ACE	4.14e-05	4	92	2	11956670
Pubmed	TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages.	TLR1 TLR9	4.14e-05	4	92	2	25911242
Pubmed	Chemokine, cytokine and type I interferon production induced by Toll-like receptor activation in common variable immune deficiency.	TLR9 TLR8	4.14e-05	4	92	2	27392462
Pubmed	Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.	TLR9 TLR8	4.14e-05	4	92	2	25187660
Pubmed	TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns.	TLR9 TLR8	4.14e-05	4	92	2	23826189
Pubmed	Associations between toll-like receptors and interleukin-4 in the lungs of patients with tuberculosis.	TLR1 TLR9	4.14e-05	4	92	2	12600829
Pubmed	Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.	TLR1 TLR9	4.14e-05	4	92	2	16002719
Pubmed	Three novel mammalian toll-like receptors: gene structure, expression, and evolution.	TLR9 TLR8	4.14e-05	4	92	2	11022119
Pubmed	ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.	MAPK1 KPNA1	4.14e-05	4	92	2	23178880
Pubmed	Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors.	TLR9 TLR8	4.14e-05	4	92	2	23369718
Pubmed	Regulation of Toll-like receptor-induced chemokine production in murine dendritic cells by mitogen-activated protein kinases.	TLR9 TLR8	4.14e-05	4	92	2	20451253
Pubmed	Toll-like receptors 3, 7, 8, and 9 in gastric cancer.	TLR9 TLR8	4.14e-05	4	92	2	36271773
Pubmed	TLR5 Supports Development of Placental Labyrinthine Zone in Mice.	TLR1 TLR9 TLR8	4.46e-05	26	92	3	34395439
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SENP1 LAMA5 DDX56 YTHDC2 NUP93 TP53BP1	5.53e-05	250	92	6	33536335
Pubmed	Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-κB signaling pathways.	MAPK1 TLR9	6.89e-05	5	92	2	27590109
Pubmed	Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development.	TNR FANCA	6.89e-05	5	92	2	37580626
Pubmed	A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses.	TLR1 TLR9	6.89e-05	5	92	2	17998391
Pubmed	Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.	TLR9 TLR8	6.89e-05	5	92	2	16286015
Pubmed	Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.	TLR1 TLR9	6.89e-05	5	92	2	24014382
Pubmed	WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.	WDR36 PLCB2	6.89e-05	5	92	2	21940795
Pubmed	p38 activation through Toll-like receptors modulates IFN-gamma-induced expression of the Tap-1 gene only in macrophages.	MAPK1 TLR9	6.89e-05	5	92	2	14694183
Pubmed	Expression of soluble Toll-like receptors in pleural effusions.	TLR1 TLR9	6.89e-05	5	92	2	20819670
Pubmed	Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans.	TLR1 TLR9	6.89e-05	5	92	2	19771452
Pubmed	Functional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic cardiomyopathy: AT1R as a potential modifier.	HTR2A ACE	6.89e-05	5	92	2	20594303
Pubmed	Low expression of Toll-like receptors in peripheral blood mononuclear cells of pediatric patients with acute lymphoblastic leukemia.	TLR1 TLR9	6.89e-05	5	92	2	27277333
Pubmed	Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.	TLR9 TLR8	6.89e-05	5	92	2	24500834
Pubmed	Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis.	TLR1 TLR9	6.89e-05	5	92	2	19627277
Pubmed	Homozygous MED25 mutation implicated in eye-intellectual disability syndrome.	MED16 MED14	6.89e-05	5	92	2	25792360
Pubmed	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	CASP8AP2 FRY GBF1 TLR1 PLEKHG5 MAP3K2	7.31e-05	263	92	6	19773279
Interaction	SIRT6 interactions	SETD1A SENP1 WDR36 MED16 NUMA1 MED14 APEX1 DDX56 YTHDC2 NUP93 PRAME TP53BP1 KPNA1 FANCA	5.41e-07	628	88	14	int:SIRT6
Interaction	NPY2R interactions	DMXL2 GBF1 APEX1 PRAME FANCA	1.03e-05	66	88	5	int:NPY2R
Interaction	GAB2 interactions	USP34 TBC1D25 LRRK1 MAPK1 TRAPPC8 DENND4C	2.26e-05	130	88	6	int:GAB2
Interaction	CNPY3 interactions	TLR1 NUMA1 VPS13A TLR9 SLITRK6 TLR8 DENND4C	2.41e-05	196	88	7	int:CNPY3
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR9 TLR8	4.10e-06	10	60	3	948
ToppCell	18-Airway-Epithelial-Goblet-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	FSIP2 L3MBTL1 SACS SERINC4 MED14 ACE	8.37e-07	153	93	6	14a60220e169ce642771636de982a7b02e5b2608
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DMXL2 URB1 GBF1 WDR36 ANKRD36C MAST2	2.60e-06	186	93	6	8571956890fc9894d766ba294a28e376b4aba428
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	USP34 MED16 PGAP1 NUMA1 QPCT PLCB2 TLR8	1.30e-05	192	92	7	6164_DN
Drug	Ethylmaleimide	SENP1 PAH APEX1 MAPK1	1.33e-05	36	92	4	ctd:D005033
Drug	Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A	USP34 DMXL2 PGAP1 VPS13A MED14 YTHDC2 MAST2	1.64e-05	199	92	7	2802_DN
Drug	LY 294002; Down 200; 0.1uM; HL60; HT_HG-U133A	SETD1A URB1 L3MBTL1 IL1RAPL2 MED16 NUMA1 FBXL2	1.64e-05	199	92	7	2676_DN
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	L3MBTL1 MED16 NUMA1 VPS13A MED14 MMP8 FBXL2	1.69e-05	200	92	7	7534_UP
Disease	seropositivity measurement, Chlamydia pneumoniae seropositivity	L3MBTL1 NUMA1	2.75e-05	3	90	2	EFO_0007034, EFO_0007035
Disease	breast cancer (is_implicated_in)	NCOA6 APEX1 MMP8 ACE FANCA	9.86e-05	150	90	5	DOID:1612 (is_implicated_in)
Disease	IgA glomerulonephritis (is_implicated_in)	TLR1 TLR9 ACE	1.05e-04	30	90	3	DOID:2986 (is_implicated_in)
Disease	melanoma	CD163L1 UBR4 QPCT APEX1 MMP8 PRAME	1.15e-04	248	90	6	C0025202
Disease	proteinuria (is_implicated_in)	TLR9 ACE	1.91e-04	7	90	2	DOID:576 (is_implicated_in)
Disease	breast cancer (is_marker_for)	L3MBTL1 MAPK1 TLR9 MMP8 PRAME	2.62e-04	185	90	5	DOID:1612 (is_marker_for)
Disease	pre-malignant neoplasm (implicated_via_orthology)	ACE BID	3.27e-04	9	90	2	DOID:0060071 (implicated_via_orthology)
Disease	ureteral obstruction (implicated_via_orthology)	MAPK1 ACE	3.27e-04	9	90	2	DOID:5199 (implicated_via_orthology)
Disease	Malignant Head and Neck Neoplasm	MAPK1 PRAME FANCA	3.32e-04	44	90	3	C0278996
Disease	Astrocytosis	MAPK1 TNR	1.21e-03	17	90	2	C3887640
Disease	Gliosis	MAPK1 TNR	1.21e-03	17	90	2	C0017639
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR9	1.21e-03	17	90	2	DOID:8677 (biomarker_via_orthology)
Disease	uridine diphosphate measurement	CDKL5 YTHDC2	1.69e-03	20	90	2	EFO_0010545
Disease	Head Neoplasms	MAPK1 PRAME	2.43e-03	24	90	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	MAPK1 PRAME	2.43e-03	24	90	2	C0887900
Disease	Cancer of Head	MAPK1 PRAME	2.43e-03	24	90	2	C0751177
Disease	Neck Neoplasms	MAPK1 PRAME	2.64e-03	25	90	2	C0027533
Disease	Cancer of Neck	MAPK1 PRAME	2.64e-03	25	90	2	C0746787
Disease	anogenital venereal wart (is_marker_for)	TLR9 TLR8	2.85e-03	26	90	2	DOID:11168 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLAPSATKLHISLSL	BPIFB3	386	P59826
VLALSVSTPKHLHSL	ACE	1021	P12821
VSTPKHLHSLNLLSS	ACE	1026	P12821
LSPSCLSLLHLQEKN	HTR2A	61	P28223
EVHNKASLTPLLLSI	ANKRD30A	166	Q9BXX3
LNSHVLILSLQLSKA	ANKRD36B	1081	Q8N2N9
KSASLVHLSLANCPI	CEP78	146	Q5JTW2
VLPLLLTSSHHNALL	DMXL2	661	Q8TDJ6
LHSVSHLLSSLQLLP	DNHD1	2591	Q96M86
LLSHSLLPALCDSKI	APEX1	286	P27695
KSLNASSGHLALILS	CD163L1	1351	Q9NR16
SAILSFTSLIKHLNL	CASP8AP2	1071	Q9UKL3
LKLLFLSKNHLSSVP	FLRT2	161	O43155
THLLLDALPSVQKLS	C17orf113	401	A0A1B0GUU1
LLLKSSGQSAQLLSH	NUP93	501	Q8N1F7
LLLHVQISKAFPVSS	MMP8	11	P22894
SNIISTLNPTAKRHL	QPCT	121	Q16769
HIARLSQKQTPLLLS	PIK3C2G	656	O75747
SAQRLSLLLTHVPLS	KCNK6	141	Q9Y257
LNSHVLILSLQLSKA	ANKRD36C	1506	Q5JPF3
LHRDLKPSNLLLNTT	MAPK1	146	P28482
QLSIHCPKLQALSLS	FBXL2	306	Q9UKC9
ILPLLTLSCSSTHIN	OR8D2	181	Q9GZM6
LTPTTVIRLNKHLLS	MKKS	111	Q9NPJ1
LLEIDISSNKLSHLP	LRRK1	331	Q38SD2
VSSTLLKQHLSLEPC	KDM5D	281	Q9BY66
SHVNLSATKLPLEAL	CARMIL3	426	Q8ND23
TPSRILSHLQQDSLK	DDX56	141	Q9NY93
LPFKSHSKLSANVLI	FSIP2	4751	Q5CZC0
LCSLPTHLLAKLSFA	L3MBTL1	821	Q9Y468
NSLLLIIIKSEPSLH	OR52A4P	46	A6NMU1
SPSLHKHLTIRLNIS	PCDHGC5	431	Q9Y5F6
VLHKASRPALSLQET	MAP3K2	16	Q9Y2U5
HSVSTLEKTLPQLLA	LAMA5	2681	O15230
PTHFILNTASLLSVL	ORMDL1	121	Q9P0S3
LNLTHLALKDSPATC	KIR3DX1	331	Q9H7L2
THLDKRSLPALTNII	PAH	81	P00439
ASIPTILTHSALNIL	MED14	1171	O60244
ISSTLKSLLRPHFLN	MED16	556	Q9Y2X0
VTPLLKLSCSDTHLN	OR1F1	181	O43749
APKLTLASQTNAALL	NCOA6	1351	Q14686
PALAKHATTNLLLSS	CCDC71	131	Q8IV32
ITSLHSLNAFLLPIK	GMPS	501	P49915
PASILLHSNIASLVK	GNPAT	436	O15228
APQSALHRLKTTAAI	C16orf96	556	A6NNT2
SHTLTQILTHSPVLK	FANCA	321	O15360
LISTPLQSHLQAIKT	CCDC73	1016	Q6ZRK6
QSLPSSVLHIIKSTF	C1orf112	86	Q9NSG2
TAALTCPKTSLLHIA	DENND4C	1081	Q5VZ89
TAQILLKALTNLPHT	EIF3K	66	Q9UBQ5
LALLLAKKVASHTPS	BID	151	P55957
ILSLKTFAPQVHSLL	MARF1	1001	Q9Y4F3
SLSGKQLLPLSSSVH	MAST2	106	Q6P0Q8
ILPKILAKLSLHSSN	CCDC38	251	Q502W7
TLLSKVFLQHLSPLL	GBF1	1621	Q92538
ALKQPLSAHALSDLL	FRY	1876	Q5TBA9
LLTLQKSIHSASTPS	CDKL5	801	O76039
HTANIESPTSILKAL	SACS	3351	Q9NZJ4
TSTQALVSELLPAKH	NUMA1	1351	Q14980
IISSNRSHIVKLPLS	PARP6	421	Q2NL67
PSLNDHLKHLLTSLS	PACRGL	191	Q8N7B6
LSALPKTQHDLSSIL	NXF2	471	Q9GZY0
SLLACISLHSQTPVL	SLITRK6	11	Q9H5Y7
LALLPSLSHCSQLTT	PRAME	396	P78395
QLPHPAALISSKSLS	TBC1D25	526	Q3MII6
QSLLHLLSSPKESIK	KPNA1	341	P52294
HRNSSLLPLSSKELS	IL1RAPL2	666	Q9NP60
PLHLSRCLSSSKNTL	SENP1	216	Q9P0U3
AKLTGILSHSPSLLN	NUDT12	26	Q9BQG2
APSSTEISLKLHIAQ	PGAP1	541	Q75T13
TIRNLPLDHASLVKS	SETD1A	1206	O15047
LSPVLVKLLATHFSA	URB1	1036	O60287
KLLSSSNELVTRHLP	ROBO4	701	Q8WZ75
LEKSSVLPIAHLNIS	TLR1	151	Q15399
SPLKRSHSLAKLGSL	SSH1	971	Q8WYL5
PHLLKSKSEASLLQL	PLEKHG5	871	O94827
LSLSFNSLSHVPPKL	TLR8	206	Q9NR97
LSNLTLQHIPKTISL	SUN5	271	Q8TC36
SLNKHLLSNLAAILT	ZNF618	726	Q5T7W0
VHSLNLLLKSIGATL	VPS13A	2801	Q96RL7
LPKSLISLSLSHTNI	TLR9	141	Q9NR96
IHESLSLLRPQSKIS	SPATA31D1	706	Q6ZQQ2
LLQAVLLVHLHSPTS	SERINC4	131	A6NH21
NILSLPITAKVATHL	TNR	401	Q92752
SHLPQIKTSLAPLAT	HIVEP3	1256	Q5T1R4
PVRSHSSLSLNLVSL	nan	26	Q8N8P6
LASTPATTLHLLQLS	TP53BP1	331	Q12888
LNLSLPLKSVHRLSL	UNQ9370/PRO34162	131	Q6UXP9
LALVKHPLTANASRS	PLCB2	131	Q00722
LQKHPTLKLILSSAA	YTHDC2	336	Q9H6S0
PSVEQLSSLIKTSLH	TRAPPC8	1301	Q9Y2L5
ISSHLKALSDKQSLP	USP34	1196	Q70CQ2
QSLPLAASLKHTLLS	UBR4	1276	Q5T4S7
RSPTNSLLKHKSLSL	TOB2	221	Q14106
LCLQRAPASKTLTLH	USP17L2	256	Q6R6M4
SQLSSLAVPLLLHAL	UNC79	1021	Q9P2D8
KILIHSVSLSSSPNI	WDR36	571	Q8NI36
KSQASLLSLPFIHIT	PP6455	76	Q8WZ26