Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentGLI-SUFU complex

GLI1 SUFU

1.05e-044882GO:1990788
DomainDynein_heavy_chain_D4_dom

DNAH1 DNAH11

1.84e-0314862IPR024317
DomainDynein_HC_stalk

DNAH1 DNAH11

1.84e-0314862IPR024743
DomainDynein_heavy_dom-2

DNAH1 DNAH11

1.84e-0314862IPR013602
DomainDHC_N2

DNAH1 DNAH11

1.84e-0314862PF08393
DomainMT

DNAH1 DNAH11

1.84e-0314862PF12777
DomainAAA_8

DNAH1 DNAH11

1.84e-0314862PF12780
DomainATPase_dyneun-rel_AAA

DNAH1 DNAH11

1.84e-0314862IPR011704
DomainAAA_5

DNAH1 DNAH11

1.84e-0314862PF07728
DomainDHC_fam

DNAH1 DNAH11

2.12e-0315862IPR026983
DomainDynein_heavy_dom

DNAH1 DNAH11

2.12e-0315862IPR004273
DomainDynein_heavy

DNAH1 DNAH11

2.12e-0315862PF03028
DomainCarboxyPept-like_regulatory

TENM4 CPD

2.72e-0317862IPR008969
DomainDH_1

TIAM1 AKAP13 ARHGEF17

3.07e-0363863PS00741
DomainPH_dom-like

TIAM1 TRIOBP AKAP13 EPS8L3 PLD2 RTKN ARHGEF17

3.50e-03426867IPR011993
DomainRhoGEF

TIAM1 AKAP13 ARHGEF17

3.81e-0368863SM00325
DomainPH

TIAM1 TRIOBP AKAP13 PLD2 RTKN

4.13e-03229865PF00169
DomainRhoGEF

TIAM1 AKAP13 ARHGEF17

4.13e-0370863PF00621
DomainDH_2

TIAM1 AKAP13 ARHGEF17

4.13e-0370863PS50010
DomainDH-domain

TIAM1 AKAP13 ARHGEF17

4.30e-0371863IPR000219
Domain-

TIAM1 AKAP13 ARHGEF17

4.30e-03718631.20.900.10
PathwayPID_LYSOPHOSPHOLIPID_PATHWAY

TIAM1 NFKBIA MMP2 PLD2 GNAZ

1.71e-0565705M15
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA4F CELSR1 ABCA2 SARS2 RPAP1 CHST15 LONRF1 GLI1 PFAS AKAP13 TBC1D25 CACNA1H GPC2 GNAZ SUFU STK11IP CTSZ RYR1

2.82e-101105881835748872
Pubmed

RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer.

ITCH GLI1 SUFU

3.11e-07688331278361
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

WWC2 RPAP1 ACD KLHDC3 PDLIM7 ZCCHC8 NFKBIA TJP2 PLD2 LAS1L FBLIM1 RTKN BEGAIN

2.10e-061038881326673895
Pubmed

The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.

EPHB2 TIAM1

6.33e-06288217440041
Pubmed

Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells.

GLI1 SUFU

6.33e-06288229249966
Pubmed

Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells.

NFKBIA MMP2

6.33e-06288219816602
Pubmed

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

GLI1 SUFU

6.33e-06288210559945
Pubmed

MTA1 promotes the invasion and migration of oral squamous carcinoma by inducing epithelial-mesenchymal transition via the hedgehog signaling pathway.

MTA1 GLI1

6.33e-06288231152708
Pubmed

Characterization of the physical interaction of Gli proteins with SUFU proteins.

GLI1 SUFU

6.33e-06288212426310
Pubmed

Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3).

ZCCHC8 ROS1

6.33e-06288227121553
Pubmed

Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle.

CACNA1H RYR1

6.33e-06288237837625
Pubmed

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

DNAH1 DNAH11

6.33e-06288224360805
Pubmed

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9.

TIAM1 MMP2

6.33e-06288223440286
Pubmed

Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis.

GLI1 SUFU

6.33e-06288225373737
Pubmed

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

KIAA1671 GLI1 SUFU

1.04e-051788327234298
Pubmed

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.

GLI1 SUFU

1.90e-05388221816948
Pubmed

The crosstalk of mTOR/S6K1 and Hedgehog pathways.

GLI1 SUFU

1.90e-05388222439934
Pubmed

Arhgap36-dependent activation of Gli transcription factors.

GLI1 SUFU

1.90e-05388225024229
Pubmed

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

GLI1 SUFU

1.90e-05388224854174
Pubmed

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

GLI1 SUFU

1.90e-05388224217340
Pubmed

Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner.

GLI1 SUFU

1.90e-05388222365972
Pubmed

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.

GLI1 SUFU

1.90e-05388228965847
Pubmed

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal.

ITCH GLI1

1.90e-05388220818436
Pubmed

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

GLI1 SUFU

1.90e-05388224311597
Pubmed

SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.

GLI1 SUFU

1.90e-05388218829525
Pubmed

Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.

GLI1 SUFU

1.90e-05388221543335
Pubmed

Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex.

CHST15 CHST14

1.90e-05388218819920
Pubmed

ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.

TJP2 MMP2

1.90e-05388230713254
Pubmed

Mutations in SUFU predispose to medulloblastoma.

GLI1 SUFU

1.90e-05388212068298
Pubmed

Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings: A positive feedback loop regulation.

MMP2 FBLIM1

1.90e-05388229203120
Pubmed

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.

GLI1 SUFU

1.90e-05388235831023
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

CCDC59 LOXHD1 GANAB SARS2 TIAM1 KLHDC3 TJP2 HTATSF1 PFAS AKAP13 BRCC3 GIT2 LAS1L

2.04e-051284881317353931
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PTGES2 ABCA2 MTA1 ITCH SARS2 B4GAT1 TIAM1 ZCCHC8 LONRF1 TRIOBP BRCC3 RIPK4 DCAF5

2.06e-051285881335914814
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

GLI1 SUFU DNAH11

3.46e-052588327340223
Pubmed

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.

EPHB2 MMP2

3.79e-05488217428795
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH1 DNAH11

3.79e-05488218492703
Pubmed

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.

GLI1 SUFU

3.79e-05488210531011
Pubmed

Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.

NFKBIA MMP2

3.79e-05488220652762
Pubmed

Molecular motors: the driving force behind mammalian left-right development.

DNAH1 DNAH11

3.79e-05488210652513
Pubmed

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.

GLI1 SUFU

3.79e-05488229662197
Pubmed

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

GLI1 SUFU

3.79e-05488216316410
Pubmed

The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc.

AKAP13 RTKN

3.79e-05488219696020
Pubmed

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.

GLI1 SUFU

3.79e-05488230973324
Pubmed

Primary cilia and Gli3 activity regulate cerebral cortical size.

EPHB2 GLI1 TJP2

5.45e-052988321976438
Pubmed

Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner.

GLI1 SUFU

6.30e-05588210920228
Pubmed

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

GLI1 SUFU

6.30e-05588221076395
Pubmed

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

ITCH GLI1

6.30e-05588217115028
Pubmed

Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.

GLI1 SUFU

6.30e-05588226120032
Pubmed

Gli regulation by the opposing activities of fused and suppressor of fused.

GLI1 SUFU

6.30e-05588210806483
Pubmed

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

ITCH SUFU

6.30e-05588229515120
Pubmed

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.

GLI1 SUFU

6.30e-05588210564661
Pubmed

MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.

ITCH GLI1

6.30e-05588230675521
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KIAA1671 WWC2 ITCH TIAM1 ZCCHC8 TJP2 AKAP13 BRCC3 RTKN ARHGEF17

6.49e-05861881036931259
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GANAB TENM4 RPAP1 CHST15 CACNA1H ARHGEF17 DCAF5

8.03e-0540788712693553
Pubmed

Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.

GLI1 SUFU

9.43e-05688219432668
Pubmed

Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling.

GLI1 SUFU

9.43e-05688239217245
Pubmed

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.

GLI1 SUFU

9.43e-05688216254602
Pubmed

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.

GLI1 SUFU

9.43e-05688221209912
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

KIAA1671 SEMA4F LOXHD1 RPAP1 AKAP13 AMER3 MMP2 ARHGEF17 RYR1

1.04e-0473688929676528
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

TIAM1 AKAP13 ARHGEF17

1.24e-043888319911011
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

TIAM1 AKAP13 ARHGEF17

1.24e-043888311756498
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH1 DNAH11

1.32e-0478829256245
Pubmed

Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.

TIAM1 TJP2

1.32e-04788222044751
Pubmed

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

GANAB TENM4 TRIOBP

1.34e-043988324095980
Pubmed

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.

GLI1 TJP2 ARHGEF17

1.45e-044088328323616
Pubmed

Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance.

CHST15 CHST14

1.75e-04888218079434
Pubmed

Expression of hedgehog signalling components in adult mouse testis.

GLI1 SUFU

1.75e-04888216958114
Pubmed

Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation.

EPHB2 GIT2

1.75e-04888217310244
Pubmed

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.

GLI1 SUFU

1.75e-04888211960000
Pubmed

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.

EPHB2 TIAM1

1.75e-04888214988728
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

WWC2 GANAB RPAP1 SMCHD1 TJP2 PFAS BRCC3 CPD PLD2 SUFU

1.78e-04974881028675297
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

TIAM1 AKAP13 ARHGEF17

1.80e-044388312376548
Pubmed

DNA cloning using in vitro site-specific recombination.

FZD8 SEMA4F PTGES2 TRIOBP TJP2 BRCC3 GPC2 PLD2 CTSZ

1.84e-0479488911076863
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

EPHB2 CELSR1 ABCA2 NEU1 GANAB B4GAT1 CHST14 BRCC3 CPD MMP2 CTSZ

2.24e-041201881135696571
Pubmed

Polymorphism of the Apl (Neu-1) locus in the mouse.

NEU1 HLA-H

2.25e-0498827141491
Pubmed

SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.

SOX12 FBLIM1

2.25e-04988231492871
Pubmed

Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors.

GLI1 SUFU

2.25e-04988228781964
Pubmed

Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.

GLI1 SUFU

2.25e-04988221795282
Pubmed

Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.

EPHB2 MMP2

2.25e-04988218713744
Pubmed

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.

GLI1 SUFU

2.25e-04988227802276
Pubmed

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.

GLI1 SUFU

2.25e-04988226261006
Pubmed

The sonic hedgehog-patched-gli pathway in human development and disease.

GLI1 SUFU

2.25e-04988211001584
Pubmed

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.

CELSR1 TJP2

2.25e-04988220704721
Pubmed

The loss of Hh responsiveness by a non-ciliary Gli2 variant.

GLI1 SUFU

2.25e-04988225834022
Pubmed

Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis.

GLI1 SUFU

2.81e-041088238358805
Pubmed

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

MTA1 BRCC3

2.81e-041088234180153
Pubmed

Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling.

GLI1 SUFU

2.81e-041088227849569
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MTA1 ERCC6 ZCCHC8 TJP2 AKAP13 LAS1L BEGAIN

2.94e-0450388716964243
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KIAA1671 WWC2 GANAB TIAM1 PDLIM7 TRIOBP PFAS BRCC3 CPD SUFU

3.21e-041049881027880917
Pubmed

CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.

MTA1 GANAB DCAF5

3.35e-045388334026424
Pubmed

Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation.

GLI1 SUFU

3.43e-041188236252002
Pubmed

Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia.

GLI1 SUFU

3.43e-041188230791390
Pubmed

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

ITCH ERCC6

3.43e-041188217996703
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ITCH GANAB SARS2 RPAP1 TIAM1 TRIOBP HTATSF1 PFAS AKAP13 CPD LAS1L DCAF5

3.63e-041487881233957083
Pubmed

Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning.

GLI1 SUFU

4.11e-041288222182519
Pubmed

Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.

GLI1 SUFU

4.11e-041288228412462
Pubmed

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.

CELSR1 TJP2

4.11e-041288223406901
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

MTA1 GANAB SMCHD1 PFAS BRCC3 LAS1L HMCES

4.20e-0453488735032548
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

EPHB2 SEMA4F NRTN INHA ITGA4

4.53e-0425188529031500
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

MTA1 ZCCHC8 HTATSF1 EGFLAM LAS1L

4.53e-0425188528077445
CoexpressionVERRECCHIA_DELAYED_RESPONSE_TO_TGFB1

EPHB2 MTA1 MMP2 ITGA4

6.88e-0637874M16643
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

EPHB2 SEMA4F CELSR1 TENM4 TIAM1 PDLIM7 GLI1 AKAP13 CPD RIPK4 ITGA4 GNAZ FBLIM1

2.36e-058068713gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

TENM4 PDLIM7 ADAM33 PFAS RIPK4 LAS1L FBLIM1

7.60e-08182887ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 WWC2 RPAP1 GLI1 CACNA1H GNAZ

1.28e-06174886c58328c2f262506a4518f49f148e29874faf9171
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4F PDLIM7 CACNA1H EGFLAM FBLIM1

6.99e-06134885bffd6ce8998368d4f486b64c220eab3a44ba147b
ToppCellsevere-Others-CD34+_GATA2+_cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

HOXA7 SOX12 ZNF667 MMP2 RTKN

2.83e-05179885dd789a1b7327d6f9ed5272f3eb54bd43f7ae8d78
ToppCellE15.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDLIM7 ADAM33 EGFLAM ITGA4 BEGAIN

2.90e-0518088538035cf2c6fbc443ea10ca7e942572715ed572da
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4F ERCC6 PFAS RTKN SUFU

2.98e-05181885e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4F ERCC6 PFAS RTKN SUFU

2.98e-05181885d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell5'-Adult-LymphNode-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDLIM7 ADAM33 CACNA1H EGFLAM ARHGEF17

3.14e-05183885d67454baf0cf791a743b51afd1cb25bfb5765385
ToppCell5'-Adult-LymphNode-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDLIM7 ADAM33 CACNA1H EGFLAM ARHGEF17

3.14e-05183885e49ac8314b6fe98426b1514ea68d646297b8bc0f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LOXHD1 TENM4 ROS1 DNAH1 DNAH11

3.22e-051848852cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LOXHD1 TENM4 ROS1 DNAH1 DNAH11

3.22e-05184885ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LOXHD1 TENM4 ROS1 DNAH1 DNAH11

3.22e-051848852b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1H EGFLAM ITGA4 SUFU ARHGEF17

3.22e-05184885327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB2 GLI1 CACNA1H C1orf216 MMP2

3.31e-051858851b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB2 NRTN MMP2 FBLIM1 ARHGEF17

3.40e-05186885827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCelltumor_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

CACNA1H EGFLAM ITGA4 ARHGEF17 DNAH11

3.66e-051898859c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA7 CELSR1 TENM4 TIAM1 NFKBIA

3.85e-05191885ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDLIM7 ADAM33 ITGA4 ARHGEF17 DNAH11

3.95e-0519288524e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCellLAM-LAM-LAM+|LAM / Condition, Lineage and Cell class

NECAB2 KCNC2 EGFLAM MMP2 FBLIM1

4.15e-051948854ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCellLAM-LAM|LAM / Condition, Lineage and Cell class

NECAB2 KCNC2 EGFLAM MMP2 FBLIM1

4.15e-051948854c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM7 ADAM33 EGFLAM MMP2 FBLIM1

4.25e-051958852eed0332e338d6f0dbcb399d9d36c4611d491b0a
ToppCellP07-Mesenchymal-myocytic_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TENM4 NRTN PDLIM7 ADAM33 MMP2

4.46e-05197885378299fe2ec6ed2fc858febb78ff1ac0898e457d
DrugEdrophonium chloride [116-38-1]; Up 200; 19.8uM; MCF7; HT_HG-U133A

SOX12 MTA1 ACBD4 TIAM1 PDLIM7 MRM1 CACNA1H ARHGEF17

9.22e-071988781519_UP
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A

EPHB2 SEMA4F ABCA2 ACBD4 ZNF74 CACNA1H EMSY

9.62e-061948774411_DN
DrugTamoxifen citrate [54965-24-1]; Down 200; 7uM; HL60; HG-U133A

MRPS18A ITCH ERCC6 RPAP1 B4GAT1 MRM1 HMCES

9.94e-061958771366_DN
Drug5155877; Down 200; 10uM; PC3; HT_HG-U133A

SEMA4F ACBD4 PDLIM7 MRM1 TRIOBP HTATSF1 CTSZ

1.10e-051988776569_DN
DrugSulfamethizole [144-82-1]; Down 200; 14.8uM; PC3; HT_HG-U133A

EPHB2 HOXA7 MRM1 ZNF74 AKAP13 ARHGEF17 CTSZ

1.10e-051988775798_DN
DrugHeptaminol hydrochloride [543-15-7]; Down 200; 22uM; MCF7; HT_HG-U133A

EPHB2 SOX12 RPAP1 PDLIM7 PLD2 GNAZ EMSY

1.13e-051998771703_DN
DrugCQ-S

SARS2 B4GAT1 RYR1

3.53e-0517873CID000072462
DrugSANT-1 compound

GLI1 SUFU

8.62e-054872ctd:C468919
DrugThiostrepton [1393-48-2]; Down 200; 2.4uM; PC3; HT_HG-U133A

EPHB2 FZD8 TENM4 ACBD4 ZNF667 TRIOBP

9.26e-051918764563_DN
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A

ABCA2 MTA1 KLHDC3 PDLIM7 CPD PLD2

9.80e-051938763624_DN
DrugPentolinium bitartrate [52-62-0]; Down 200; 7.4uM; PC3; HT_HG-U133A

EPHB2 TIAM1 SP140L HTATSF1 CPD HMCES

9.80e-051938767375_DN
DrugPrazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; HL60; HT_HG-U133A

MTA1 ITCH ACD HTATSF1 HMCES EMSY

9.80e-051938763098_DN
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A

EPHB2 MRM1 ZNF667 AKAP13 EMSY CTSZ

1.01e-041948764524_DN
DrugMethylergometrine maleate [113-42-8]; Up 200; 8.8uM; MCF7; HT_HG-U133A

RPAP1 ACBD4 HTATSF1 DELE1 GIT2 EMSY

1.01e-041948765303_UP
DrugRisperidone [106266-06-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

ABCA2 RPAP1 PDLIM7 AKAP13 MMP2 BEGAIN

1.04e-041958763508_DN
DrugNetilmicin sulfate [56931-57-2]; Down 200; 2.8uM; MCF7; HT_HG-U133A

EPHB2 MTA1 ERCC6 RPAP1 PDLIM7 GIT2

1.07e-041968763524_DN
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

EPHB2 MRM1 TRIOBP HTATSF1 GNAZ EMSY

1.07e-041968761708_DN
DrugPargyline hydrochloride [306-07-0]; Up 200; 20.4uM; HL60; HG-U133A

EPHB2 ABCA2 INHA PLD2 CTSZ BEGAIN

1.07e-041968761418_UP
DrugDantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SOX12 ABCA2 MTA1 ACBD4 CPD EMSY

1.07e-041968762329_DN
DrugAllantoin [97-59-6]; Down 200; 25.2uM; MCF7; HT_HG-U133A

SEMA4F SOX12 GANAB PDLIM7 EFCAB2 GNAZ

1.07e-041968761678_DN
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

EPHB2 SOX12 RPAP1 PDLIM7 CPD MMP2

1.07e-041968763534_DN
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

EPHB2 SOX12 WWC2 TIAM1 AKAP13 GIT2

1.07e-041968767369_DN
DrugAntazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A

MTA1 PDLIM7 MRM1 ZNF74 RIPK4 PLD2

1.07e-041968766775_DN
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

TIAM1 INHA PDLIM7 MMP2 PLD2 BEGAIN

1.07e-041968761654_UP
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

WWC2 MTA1 PDLIM7 CPD RIPK4 GIT2

1.07e-041968762844_DN
Drug3-Acetamidocoumarin [779-30-6]; Down 200; 19.6uM; HL60; HT_HG-U133A

EPHB2 SOX12 PDLIM7 ZNF667 TRIOBP MMP2

1.07e-041968762941_DN
DrugBaclofen (R,S) [1134-47-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A

EPHB2 MTA1 ACBD4 SP140L CACNA1H ARHGEF17

1.07e-041968761536_UP
DrugRonidazole [7681-76-7]; Up 200; 20uM; PC3; HT_HG-U133A

EPHB2 MTA1 RPAP1 ACBD4 ZNF667 ZNF74

1.07e-041968767131_UP
DrugLoracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A

MTA1 RPAP1 PDLIM7 MRM1 GIT2 PLD2

1.10e-041978763532_DN
DrugDiprophylline [479-18-5]; Up 200; 15.8uM; HL60; HT_HG-U133A

EPHB2 WWC2 TRIM58 PDLIM7 ZNF667 EFCAB2

1.10e-041978761853_UP
DrugPseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT_HG-U133A

SOX12 MTA1 NRTN ZNF74 ARHGEF17 CTSZ

1.10e-041978762766_UP
Drugestradiol, USP; Down 200; 0.1uM; MCF7; HT_HG-U133A

MRPS18A SOX12 PDLIM7 TRIOBP DELE1 GIT2

1.13e-041988766928_DN
DrugTiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A

EPHB2 NRTN PDLIM7 GLI1 ARHGEF17 BEGAIN

1.13e-041988764171_UP
DrugDiazoxide [364-98-7]; Down 200; 17.4uM; MCF7; HT_HG-U133A

EPHB2 SOX12 ABCA2 RPAP1 CPD PLD2

1.13e-041988767168_DN
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; HL60; HT_HG-U133A

EPHB2 SOX12 ABCA2 MRM1 ZNF667 BEGAIN

1.13e-041988763128_UP
DrugChlorhexidine [55-56-1]; Down 200; 8uM; PC3; HT_HG-U133A

EPHB2 PDLIM7 MRM1 AKAP13 CPD GNAZ

1.13e-041988766302_DN
DrugMilrinone [78415-72-2]; Down 200; 19uM; MCF7; HT_HG-U133A

SOX12 PDLIM7 SMCHD1 TRIOBP CPD DELE1

1.13e-041988767210_DN
DrugMetixene hydrochloride [1553-34-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

SEMA4F MTA1 MRM1 CACNA1H GIT2 EMSY

1.13e-041988763313_DN
DrugMetolazone [17560-51-9]; Up 200; 11uM; PC3; HG-U133A

EPHB2 WWC2 ACD TRIOBP DELE1 GIT2

1.16e-041998761932_UP
DrugIsometheptene mucate; Up 200; 8.2uM; MCF7; HT_HG-U133A

EPHB2 MTA1 MRM1 ZNRF4 ARHGEF17 BEGAIN

1.16e-041998766524_UP
Drugestradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A

SEMA4F ABCA2 PDLIM7 EFCAB2 RIPK4 GIT2

1.16e-041998767000_DN
DrugLDE225

GLI1 SUFU

1.43e-045872ctd:C561435
Diseasepre-malignant neoplasm (biomarker_via_orthology)

GLI1 NFKBIA SUFU

1.37e-0517823DOID:0060071 (biomarker_via_orthology)
Diseasehearing impairment

LOXHD1 ERCC6 TRIOBP TJP2

1.64e-0498824C1384666
Diseasepneumococcal meningitis

CELSR1 ROS1

2.11e-048822EFO_1001114
DiseaseCancer of Nasopharynx

NFKBIA MMP2

2.71e-049822C0238301
Diseaserenal sinus adipose tissue measurement

TIAM1 TJP2

5.83e-0413822EFO_0004864
DiseaseMalignant neoplasm of breast

ERCC6 B4GAT1 PDLIM7 GLI1 NFKBIA ADAM33 GPC2 MMP2 PLD2 EMSY

7.79e-0410748210C0006142
Diseaseendometriosis (biomarker_via_orthology)

NFKBIA MMP2

8.93e-0416822DOID:289 (biomarker_via_orthology)
Diseaseocular hypertension (biomarker_via_orthology)

GLI1 MMP2

1.01e-0317822DOID:9282 (biomarker_via_orthology)
DiseaseNasopharyngeal carcinoma

NFKBIA MMP2

1.70e-0322822C2931822
Diseasecolon adenocarcinoma (is_marker_for)

PFAS MMP2

2.20e-0325822DOID:234 (is_marker_for)
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

EPHB2 ERCC6 NFKBIA

2.24e-0393823DOID:3525 (biomarker_via_orthology)
Diseaseacute necrotizing pancreatitis (biomarker_via_orthology)

NFKBIA MMP2

2.37e-0326822DOID:0080998 (biomarker_via_orthology)
Diseaseeye measurement

SEMA4F AKAP13

2.56e-0327822EFO_0004731

Protein segments in the cluster

PeptideGeneStartEntry
MKPDWPRRGAAGTRV

nan

1

Q9H8V8
MGIVSWLRRGPTPRA

AMER3

506

Q8N944
NGRRIDMRPWPLGKA

EGFLAM

541

Q63HQ2
MARRGPGWRPLLLLV

CTSZ

1

Q9UBR2
MPRPPETFLRRVTGW

ACBD4

126

Q8NC06
VPSEGLWRGLREMLD

B4GAT1

231

O43505
TARLPGEDMRGQWRP

BEGAIN

406

Q9BUH8
GVREVMRAPPSGRER

AKAP13

1211

Q12802
WHGMPGRVEPILRRS

C1orf216

46

Q8TAB5
MRGWARCVLPPRREH

DNAH11

841

Q96DT5
MGWRPRRARGTPLLL

ADAM33

1

Q9BZ11
RQRSMVWPGDGLVPD

GIT2

611

Q14161
LPAMGLRAAAWEPRV

CELSR1

21

Q9NYQ6
VGLPKARRPWESDMR

ERCC6

346

Q03468
RFIWRTVTPRDKPMG

MMP2

491

P08253
SPREEPRAPWMEREG

HLA-H

66

P01893
WVLCRRMGPRSPSVI

P2RY8

46

Q86VZ1
DAMELRELTPWAGRP

NRTN

66

Q99748
EGPARGAWPSVTEMR

ARHGEF17

116

Q96PE2
VGLPKARRPWESDMR

ERCC6

346

P0DP91
MLGPGQVRLRPRVWR

EFCAB2

1

Q5VUJ9
PDGKSGRWRRLQPRM

KCNC2

201

Q96PR1
SEPRPRPEMGSWLGR

KIAA1671

646

Q9BY89
PPREEAGRLWSMVTE

GPC2

361

Q8N158
EMAPAPQGRGRFWEV

LONRF1

16

Q17RB8
MRIRIDGLGSRPEWF

LOXHD1

1616

Q8IVV2
MAEPGPEPGRAWRVL

CCDC194

1

A0A1B0GVG4
MLEWTPPRDSGGRED

EPHB2

341

P29323
QPGQDRWRGPAMERP

EPS8L3

161

Q8TE67
RWRGPAMERPLPMEQ

EPS8L3

166

Q8TE67
MWRIPADPEAGGIGR

DCAF5

306

Q96JK2
RWDTFPLGRMPGQTE

LAS1L

646

Q9Y4W2
RIGGLPMPPWRSRAE

GLI1

611

P08151
ERPQEWAMEGPRDGL

NFKBIA

6

P25963
QRLMENTEDWRPRPG

PDLIM7

146

Q9NR12
QLDWRPERRAGPSRM

HTATSF1

246

O43719
PPGWERRVDNMGRIY

ITCH

361

Q96J02
GFAWPDRMRCDRLPE

FZD8

126

Q9H461
RTPREWINMGLEPGS

DNAH1

256

Q9P2D7
TPELLGVMRRLWADP

GNAZ

121

P19086
MASGRDERPPWRLGR

CPD

1

O75976
EPWSRLGGNPLFRME

ABCA2

211

Q9BZC7
MAWEARREPGPRRAA

ITGA4

1

P13612
MPTWRSRREDGGPQC

FAM98C

326

Q17RN3
EARRGRPWEAPAPMK

FBLIM1

36

Q8WUP2
GGERARRSTPLMSWP

INHA

226

P05111
MLRWTVHLEGGPRRV

KLHDC3

1

Q9BQ90
EWSIEGRRLVPLMPR

EMSY

91

Q7Z589
PGRRELRMPCTLGWE

CACNA1H

306

O95180
TGEMRVGWARPELRP

RYR1

1096

P21817
SERIIAPMRWGLVPS

HMCES

66

Q96FZ2
MWRLPGLLGRALPRT

DELE1

1

Q14154
PWMRSSGPDRKRGRQ

HOXA7

121

P31268
REGARLETPPPWLAM

RTKN

471

Q9BST9
IEAWMPGRGRFGEVT

SARS2

406

Q9NP81
PEEPRMGLDSEEGWR

STK11IP

681

Q8N1F8
MARLPDRLSVTWPEG

SMCHD1

686

A6NHR9
PFSGERPRRIDWMVP

SEMA4F

91

O95754
RGWPVRQRHMLRPAG

TBC1D25

461

Q3MII6
MEVSPLRPRPWREAG

MRM1

121

Q6IN84
PVFQRGGTIVPRWMR

GANAB

801

Q14697
MTGERPSTALPDRRW

NEU1

1

Q99519
GPRWNRVRMPVGSPL

MRPS18A

166

Q9NVS2
MAPVRRSAKWRPGGI

CCDC59

1

Q9P031
MDPAARVVRALWPGG

PTGES2

1

Q9H7Z7
VLLPRDWQMAPGRGL

SPATA3

136

Q8NHX4
RGGSLPPVKRRRMNW

MTA1

636

Q13330
SVRCGGWPLRRLMEE

SP140L

356

Q9H930
GWPLRRLMEEGSLPN

SP140L

361

Q9H930
LMQRCWQGDPRVRPT

RIPK4

261

P57078
SWDELAVMIPRRPRE

TRIOBP

166

Q9H2D6
RLAELTGRPMRVVGW

BRCC3

106

P46736
MAGSGRLVLRPWIRE

ACD

1

Q96AP0
GMPRDPWDLPVGQRR

CHST14

121

Q8NCH0
NARRPEDRNLGPMWP

CHST15

516

Q7LFX5
APWMVEPVRRRRAPD

ZNF667

71

Q5HYK9
RGIPDEWRIFGSIPM

ZCCHC8

376

Q6NZY4
PRRELSGWLRAPGME

TJP2

11

Q9UDY2
EEPRGPDGDWLTMLR

WWC2

886

Q6AWC2
GSPIWVDRVDMGLRP

TIAM1

86

Q13009
TPGRELWRMVPAGRA

SOX12

181

O15370
WASVRVGPGPALMLR

PFAS

1206

O15067
AKRVTMGWPRPGRAL

ZNRF4

66

Q8WWF5
MGWPRPGRALVAVKA

ZNRF4

71

Q8WWF5
VPIAGGPWLITDMRR

SUFU

226

Q9UMX1
PLMGWEDEGQPFIRR

SLC24A5

246

Q71RS6
VRRDSTGMPLWLVVP

TENM4

1631

Q6N022
RKRGEGLLPVRWMAP

ROS1

2116

P08922
LLSRPEMWRAVGPVP

RPAP1

781

Q9BWH6
ERGEEPWSMQREVPR

ZNF74

96

Q16587
DRETTPRMPWRDVGV

PLD2

531

O14939
PRMPWRDVGVVVHGL

PLD2

536

O14939
MAWAPPGERLREDAR

TRIM58

1

Q8NG06
LRWVGARMGEPRESL

NECAB2

31

Q7Z6G3