Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	PTPN2 DST TBC1D10A BZW2 SPTBN2 DMD FERMT2 GCN1 PLIN3 SNX2	1.67e-05	599	63	10	GO:0050839
GeneOntologyMolecularFunction	fatty acid elongase activity	ELOVL1 ELOVL6	2.04e-04	7	63	2	GO:0009922
Domain	Actinin_actin-bd_CS	DST SPTBN2 DMD	5.07e-05	23	59	3	IPR001589
Domain	Spectrin	DST SPTBN2 DMD	5.07e-05	23	59	3	PF00435
Domain	ACTININ_2	DST SPTBN2 DMD	5.07e-05	23	59	3	PS00020
Domain	ACTININ_1	DST SPTBN2 DMD	5.07e-05	23	59	3	PS00019
Domain	HEAT_REPEAT	MROH1 HEATR4 MROH2B GCN1	7.05e-05	70	59	4	PS50077
Domain	Spectrin_repeat	DST SPTBN2 DMD	1.03e-04	29	59	3	IPR002017
Domain	Spectrin/alpha-actinin	DST SPTBN2 DMD	1.39e-04	32	59	3	IPR018159
Domain	SPEC	DST SPTBN2 DMD	1.39e-04	32	59	3	SM00150
Domain	ELO_CS	ELOVL1 ELOVL6	1.46e-04	6	59	2	IPR030457
Domain	ELO	ELOVL1 ELOVL6	2.04e-04	7	59	2	PF01151
Domain	ELO	ELOVL1 ELOVL6	2.04e-04	7	59	2	PS01188
Domain	ELO_fam	ELOVL1 ELOVL6	2.04e-04	7	59	2	IPR002076
Domain	HEAT	MROH1 HEATR4 GCN1	4.68e-04	48	59	3	PF02985
Domain	Quinoprotein_ADH-like_supfam	WDR87 CFAP57 WDR62	6.27e-04	53	59	3	IPR011047
Domain	ARM-type_fold	MROH1 DOCK8 BZW2 HEATR4 MROH2B GCN1	6.86e-04	339	59	6	IPR016024
Domain	HEAT	MROH1 HEATR4 GCN1	8.17e-04	58	59	3	IPR000357
Domain	Ldl_recept_b	LRP6 LRP1B	8.71e-04	14	59	2	PF00058
Domain	LDLRB	LRP6 LRP1B	8.71e-04	14	59	2	PS51120
Domain	LY	LRP6 LRP1B	1.00e-03	15	59	2	SM00135
Domain	LDLR_classB_rpt	LRP6 LRP1B	1.00e-03	15	59	2	IPR000033
Domain	CH	DST SPTBN2 DMD	1.14e-03	65	59	3	SM00033
Domain	Nicotinic_acetylcholine_rcpt	CHRNA2 CHRNB3	1.14e-03	16	59	2	IPR002394
Domain	HEAT_type_2	MROH1 GCN1	1.29e-03	17	59	2	IPR021133
Domain	WD40	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.34e-03	259	59	5	PF00400
Domain	CH	DST SPTBN2 DMD	1.41e-03	70	59	3	PF00307
Domain	-	DST SPTBN2 DMD	1.47e-03	71	59	3	1.10.418.10
Domain	WD40	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.56e-03	268	59	5	SM00320
Domain	CH	DST SPTBN2 DMD	1.59e-03	73	59	3	PS50021
Domain	ARM-like	MROH1 DOCK8 HEATR4 MROH2B GCN1	1.61e-03	270	59	5	IPR011989
Domain	WD40_repeat	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.66e-03	272	59	5	IPR001680
Domain	CH-domain	DST SPTBN2 DMD	1.72e-03	75	59	3	IPR001715
Domain	WD_REPEATS_1	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.83e-03	278	59	5	PS00678
Domain	WD_REPEATS_2	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.86e-03	279	59	5	PS50082
Domain	WD_REPEATS_REGION	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	1.86e-03	279	59	5	PS50294
Domain	-	CHRNA2 CHRNB3	2.38e-03	23	59	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRNA2 CHRNB3	2.38e-03	23	59	2	IPR027361
Domain	WD40_repeat_dom	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	2.44e-03	297	59	5	IPR017986
Domain	-	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	3.98e-03	333	59	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	4.09e-03	335	59	5	IPR015943
Domain	-	MROH1 HEATR4 MROH2B GCN1	5.31e-03	222	59	4	1.25.10.10
Domain	PH	ARHGAP22 SPTBN2 FERMT2 PLEKHD1	5.91e-03	229	59	4	PF00169
Domain	-	LRP6 LRP1B	6.74e-03	39	59	2	2.120.10.30
Domain	LDLR_class-A_CS	LRP6 LRP1B	7.08e-03	40	59	2	IPR023415
Domain	Neurotransmitter_ion_chnl_CS	CHRNA2 CHRNB3	8.90e-03	45	59	2	IPR018000
Domain	Ldl_recept_a	LRP6 LRP1B	8.90e-03	45	59	2	PF00057
Domain	Neur_chan_memb	CHRNA2 CHRNB3	9.29e-03	46	59	2	PF02932
Domain	-	LRP6 LRP1B	9.29e-03	46	59	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP6 LRP1B	9.29e-03	46	59	2	IPR011042
Domain	-	DST DMD TBC1D8B SLC25A23	9.30e-03	261	59	4	1.10.238.10
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNB3	3.38e-04	9	44	2	M27597
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNB3	3.38e-04	9	44	2	MM15313
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNB3	5.14e-04	11	44	2	M883
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNB3	6.16e-04	12	44	2	M48008
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	ELOVL1 ELOVL6	6.16e-04	12	44	2	MM17077
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNB3	6.16e-04	12	44	2	MM15312
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL6	8.46e-04	14	44	2	M39780
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ELOVL1 ELOVL6	8.46e-04	14	44	2	MM15840
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNB3	8.46e-04	14	44	2	M757
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNB3	9.74e-04	15	44	2	MM14704
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	PTPN2 DST USE1 ESYT1 ELOVL1 FERMT2 GCN1 PLIN3 SNX2	1.10e-06	568	65	9	37774976
Pubmed	Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.	CHRNA2 CHRNB3	1.03e-05	3	65	2	23943838
Pubmed	Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis.	MAPKBP1 WDR62	1.03e-05	3	65	2	28089251
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	DST TBC1D10A BZW2 ESYT1 SPTBN2 GCN1 PLIN3 SNX2	1.03e-05	565	65	8	25468996
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	SGMS1 ELOVL1 ELOVL6	1.76e-05	27	65	3	25269881
Pubmed	Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins.	MAPKBP1 WDR62	2.06e-05	4	65	2	23341463
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	DST DMD	2.06e-05	4	65	2	8954775
Pubmed	Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.	SPTBN2 DMD	2.06e-05	4	65	2	24064296
Pubmed	Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.	CHRNA2 CHRNB3	3.43e-05	5	65	2	9193799
Pubmed	Nicotinic acetylcholine receptors: from structure to brain function.	CHRNA2 CHRNB3	3.43e-05	5	65	2	12783266
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EPRS1 DST BZW2 ESYT1 LRP6 FERMT2 GCN1 PLIN3	5.15e-05	708	65	8	39231216
Pubmed	Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.	CHRNA2 CHRNB3	7.18e-05	7	65	2	1505988
Pubmed	Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.	CHRNA2 CHRNB3	7.18e-05	7	65	2	20231857
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	DST TBC1D10A ESYT1 DDR2 DMD FERMT2	7.51e-05	377	65	6	38117590
Pubmed	Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.	CHRNA2 CHRNB3	9.56e-05	8	65	2	17559419
Pubmed	LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.	SPTBN2 LRP6	1.23e-04	9	65	2	11357136
Pubmed	Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.	CHRNA2 CHRNB3	1.23e-04	9	65	2	8906617
Pubmed	Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.	CHRNA2 CHRNB3	1.23e-04	9	65	2	19228980
Pubmed	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.	ELOVL1 ELOVL6	1.53e-04	10	65	2	20937905
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRNA2 CHRNB3	1.53e-04	10	65	2	10336173
Pubmed	Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.	CHRNA2 CHRNB3	1.53e-04	10	65	2	20736995
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	BRD8 DST LRP1B TMEM18	1.79e-04	149	65	4	25231870
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	ELOVL1 ELOVL6	1.87e-04	11	65	2	23689133
Pubmed	Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.	CHRNA2 CHRNB3	1.87e-04	11	65	2	12225896
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP6 LRP1B	1.87e-04	11	65	2	24639464
Pubmed	The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.	MAPKBP1 WDR62	1.87e-04	11	65	2	31816041
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	DST LRP6	1.87e-04	11	65	2	16815997
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	USE1 ESYT1 ELOVL1 FERMT2 GCN1 SNX2	1.94e-04	449	65	6	31732153
Pubmed	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	CHRNA2 CHRNB3	2.24e-04	12	65	2	20584212
Pubmed	Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.	ELOVL1 CFAP57	2.65e-04	13	65	2	21574244
Pubmed	Szt2, a novel gene for seizure threshold in mice.	ELOVL1 CFAP57	2.65e-04	13	65	2	19624305
Pubmed	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.	CHRNA2 CHRNB3	3.08e-04	14	65	2	19059502
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	DST ESYT1 SPTBN2 FERMT2 GCN1 PLIN3	3.38e-04	498	65	6	36634849
Pubmed	Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.	CHRNA2 CHRNB3	3.56e-04	15	65	2	8838678
Pubmed	A high-resolution molecular atlas of the fetal mouse lower urogenital tract.	UPK1B DDR2 LRP6	3.82e-04	75	65	3	21905163
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNA2 CHRNB3	4.06e-04	16	65	2	19259974
Pubmed	WNT/β-catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development.	DMD FERMT2	5.16e-04	18	65	2	30389854
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EPRS1 BRD8 SPTBN2 GCN1 PLIN3 SNX2	5.65e-04	549	65	6	38280479
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRNA2 CHRNB3	5.76e-04	19	65	2	17373692
Pubmed	Generation and analysis of 280,000 human expressed sequence tags.	EPRS1 DST DDR2 LRP6 ELOVL6	6.34e-04	368	65	5	8889549
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP6 LRP1B	7.06e-04	21	65	2	21337463
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	FERMT2 GCN1 PLIN3 SNX2	7.28e-04	216	65	4	31519766
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	ESYT1 FERMT2 SNX2	1.05e-03	106	65	3	38891874
Pubmed	Biosynthesis of triacylglycerols.	ELOVL1 ELOVL6	1.26e-03	28	65	2	8944226
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	EPRS1 ESYT1 FERMT2 GCN1	1.37e-03	256	65	4	33397691
Pubmed	Defining the membrane proteome of NK cells.	EPRS1 SGMS1 DOCK8 BZW2 ESYT1 ELOVL1 GCN1 PLIN3	1.46e-03	1168	65	8	19946888
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	EPRS1 ESYT1 GCN1 PLIN3	1.64e-03	269	65	4	30442662
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	BRD8 SGMS1 BZW2 USE1 SPTBN2 ELOVL1 FERMT2	1.68e-03	925	65	7	28986522
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	EPRS1 DST ESYT1	1.76e-03	127	65	3	30335684
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPRS1 DST ESYT1 FERMT2 GCN1 PLIN3 WDR62	1.77e-03	934	65	7	33916271
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	NRBP1 EPRS1 SNX2	1.80e-03	128	65	3	30995482
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	TBC1D10A USE1 ESYT1 SPTBN2 LRP6	1.82e-03	467	65	5	30194290
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EPRS1 BZW2 USE1 ESYT1 CSTF3 LRP6 GCN1	1.86e-03	942	65	7	31073040
GeneFamily	Maestro heat like repeat containing	MROH1 MROH2B	3.00e-04	11	43	2	636
GeneFamily	WD repeat domain containing	WDR87 CFAP57 MAPKBP1 WDFY1 WDR62	3.78e-04	262	43	5	362
GeneFamily	Low density lipoprotein receptors	LRP6 LRP1B	4.24e-04	13	43	2	634
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA2 CHRNB3	6.49e-04	16	43	2	173
GeneFamily	Lipases\|Arylacetamide deacetylase family	AADAC LIPC	1.24e-03	22	43	2	464
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP22 SPTBN2 FERMT2 PLEKHD1	1.43e-03	206	43	4	682
ToppCell	droplet-Marrow-BM-1m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT1 CD79B ELOVL6 SNX2 WDFY1	6.77e-06	181	65	5	89c551de26de047c316c91ac1d97bdf728a33d9e
ToppCell	droplet-Marrow-BM-1m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT1 CD79B ELOVL6 SNX2 WDFY1	7.33e-06	184	65	5	69348c9237e44f7752ac01f60e733ad41580fdb8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WDR87 AIPL1 TBC1D8B CCDC144A	5.54e-05	142	65	4	f720f13b339589fa924a42e89393e5db0b26300b
ToppCell	TCGA-Kidney\|World / Sample_Type by Project: Shred V9	FMO1 GAL3ST1 SLC28A1 PTH2R	7.04e-05	151	65	4	e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CCDC178 CHRNA2 CHRNB3	7.16e-05	55	65	3	10e98fc862d89141512bdebae1231ef1a82105b0
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1-Inhibitory_Neuron.Gad1Gad2_Sst.Grm1_(Interneuron,_OLM3_(CA1_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CCDC178 CHRNA2 CHRNB3	7.16e-05	55	65	3	a55d3edca2dd9ca7a703b2b3a5941b30b5f0a6df
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Grm1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CCDC178 CHRNA2 CHRNB3	7.16e-05	55	65	3	bac333ea3914a49376105dd977a0b8493b0d2001
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NLRP7 SPTBN2 CD79B SLC25A23	8.39e-05	158	65	4	17a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NLRP7 SPTBN2 CD79B SLC25A23	8.39e-05	158	65	4	1397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NLRP7 SPTBN2 CD79B SLC25A23	8.39e-05	158	65	4	e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NLRP7 SPTBN2 CD79B SLC25A23	8.60e-05	159	65	4	6ecc3cb2daa5887b59836842be414a00cdcdaeec
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NLRP7 SPTBN2 CD79B SLC25A23	8.60e-05	159	65	4	1827493fb464bbddb2ee23f99472cfbcaf57405b
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	WDR87 AIPL1 PTH2R	8.83e-05	59	65	3	0946b53be12a9926d876c75ddf5dec414a4f8063
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	WDR87 AIPL1 PTH2R	8.83e-05	59	65	3	5da8beaf3c690861d5561ae40d4ff7c2d3732ef4
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	WDR87 AIPL1 PTH2R	8.83e-05	59	65	3	1c26fabefafd4ce05f21750ae69895c488ea1a11
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD79B CFAP57 DMD SNX2	9.24e-05	162	65	4	28b3a6ae5519a267eefb70436d3190a387d027b9
ToppCell	Mild_COVID-19-B_cell-Plasmablast\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	NLRP7 SPTBN2 CD79B SLC25A23	9.24e-05	162	65	4	b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SPTBN2 CD79B DMD SNX2	9.92e-05	165	65	4	8003fd2aa3f5c9d0e99054af4ad2d79a4a3c4829
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPRS1 DDR2 CCDC178 TTF1	1.02e-04	166	65	4	ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COLEC12 DDR2 DMD LRP1B	1.11e-04	170	65	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP22 RGL1 UPK1B WDR62	1.16e-04	172	65	4	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP22 RGL1 UPK1B WDR62	1.16e-04	172	65	4	2a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell	Severe-Lymphoid-pDC\|Severe / Condition, Lineage, Cell class and cell subclass	FMO1 NLRP7 DMD PLEKHD1	1.42e-04	181	65	4	2caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCell	Severe-Lymphoid-pDC-\|Severe / Condition, Lineage, Cell class and cell subclass	FMO1 NLRP7 DMD PLEKHD1	1.42e-04	181	65	4	277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC28A1 CCDC178 LRP1B PTH2R	1.45e-04	182	65	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	FMO1 DOCK8 SLC28A1 PTH2R	1.51e-04	184	65	4	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	WDR87 CD79B DMD SNX2	1.54e-04	185	65	4	3563dd39ec58d3273f95f5bb36b9ccdc0aafb63a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 DOCK8 SLC28A1 PTH2R	1.60e-04	187	65	4	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC28A1 CCDC178 LRP1B PTH2R	1.60e-04	187	65	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SPTBN2 CCDC178 LRP1B PTH2R	1.64e-04	188	65	4	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC178 FERMT2 PLEKHD1 LRP1B	1.67e-04	189	65	4	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST MAPKBP1 LRP1B CHRNB3	1.67e-04	189	65	4	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST MAPKBP1 LRP1B CHRNB3	1.67e-04	189	65	4	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP22 COLEC12 RGL1 DOCK8	1.67e-04	189	65	4	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|IPF / Disease state, Lineage and Cell class	COLEC12 DST DOCK8 SNX2	1.71e-04	190	65	4	e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 DOCK8 SLC28A1 PTH2R	1.71e-04	190	65	4	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	COLEC12 DST DOCK8 SNX2	1.71e-04	190	65	4	2592765016f291565697265800a232b2edef3792
ToppCell	(3)_MNP-(3)_DC_1\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	PTPN2 LIPC UPK1B DMD	1.74e-04	191	65	4	cf0ea54670ed478c3302ccfbee9f6b6706e49fcd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.78e-04	192	65	4	86d792682ba51696f503c79625dd20f87bcf651f
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SPTBN2 CCDC178 LRP1B PTH2R	1.78e-04	192	65	4	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.78e-04	192	65	4	d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 DST MROH1 ESYT1	1.81e-04	193	65	4	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 DST MROH1 ESYT1	1.81e-04	193	65	4	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.81e-04	193	65	4	bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.81e-04	193	65	4	f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.81e-04	193	65	4	374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BZW2 SPTBN2 LRP1B SNX2	1.85e-04	194	65	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	RGL1 DDR2 DMD FERMT2	1.85e-04	194	65	4	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	ARHGAP22 COLEC12 RGL1 DOCK8	1.88e-04	195	65	4	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COLEC12 FMO1 DDR2 FERMT2	1.88e-04	195	65	4	223f5f07dc28fa13a09bb589884c58043c7928c7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 COLEC12 RGL1 DOCK8	1.96e-04	197	65	4	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DST TBC1D10A BZW2 DMD	1.96e-04	197	65	4	1018aac22659c081d227d566afa29b1748c18ade
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ARHGAP22 DOCK8 PLEKHD1 PLIN3	2.00e-04	198	65	4	ba3b97bb3e1533df758e845bde7d82eb1525b057
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ARHGAP22 DOCK8 PLEKHD1 PLIN3	2.00e-04	198	65	4	436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	COLEC12 DST DDR2 FERMT2	2.04e-04	199	65	4	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK8 AIPL1 CD79B SNX2	2.04e-04	199	65	4	0eb8c72edcd34fe0f7ab9438c9c872d63576ef3a
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK8 AIPL1 CD79B SNX2	2.04e-04	199	65	4	2cdc8ae6357723b9e7c0c66be656e6f748a6aa2d
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COLEC12 DOCK8 SLC28A1 SNX2	2.04e-04	199	65	4	fde8e3ba19d19069a4d3b8db55bfe6220cf634d5
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DST TBC1D10A DMD PTH2R	2.04e-04	199	65	4	a816b0eed80530113b7e720bbd2311a544ed8ed1
Computational	Neighborhood of DDB1	EPRS1 BRD8 ESYT1 CSTF3 PLIN3 WDR62	1.73e-04	246	37	6	MORF_DDB1
Disease	primary autosomal recessive microcephaly 2 with or without cortical malformations (implicated_via_orthology)	MAPKBP1 WDR62	4.63e-06	2	64	2	DOID:0070293 (implicated_via_orthology)
Disease	metabolite measurement	ARHGAP22 FMO1 LIPC HEATR4 DDR2 SLC28A1 DMD	2.08e-04	560	64	7	EFO_0004725
Disease	lysophosphatidylcholine 15:0 measurement	LIPC LRP1B	4.14e-04	14	64	2	EFO_0020941
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA2 CHRNB3	5.45e-04	16	64	2	DOID:3635 (implicated_via_orthology)
Disease	X-24309 measurement	HEATR4 CHRNA2	8.58e-04	20	64	2	EFO_0800872
Disease	lysophosphatidylethanolamine 16:0 measurement	LIPC SLC28A1	1.46e-03	26	64	2	EFO_0010366
Disease	age at menarche	COLEC12 DST ADCK1 LRP1B PTH2R TMEM18	1.81e-03	594	64	6	EFO_0004703
Disease	intellectual disability (is_implicated_in)	DMD WDR62	1.94e-03	30	64	2	DOID:1059 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRNWMQCKSKWTEIL	TTF1	731	Q15361
VEKAEWLNKIVAQVW	ESYT1	136	Q9BSJ8
KNQLMTTNVWLKQEW	CHRNB3	71	Q05901
LLWTCIMNAVEWNKK	BZW2	296	Q9Y6E2
LWQSLIWTDMKRVKE	ADCK1	356	Q86TW2
KPWEVQWLKLEKMIN	AIPL1	216	Q9NZN9
IQAQKIWKKAIMLVW	BRD8	706	Q9H0E9
IWKKAIMLVWRAAAN	BRD8	711	Q9H0E9
WRMMWINAHLKTIQN	AADAC	31	P22760
LLWIWDKMEKQQYKS	C14orf28	106	Q4W4Y0
KNQMMTTNVWLKQEW	CHRNA2	101	Q15822
EEEMWQQRQKKWALL	FAM186B	496	Q8IYM0
IWNIILHWQVKNVMK	DMD	111	P11532
WLWKQEMDENPQQLK	CD79B	76	P40259
ENMKKTEEKWNWLLL	RAD51AP2	421	Q09MP3
MKLLWQAKMSSIQDW	RGL1	1	Q9NZL6
HFWLMVWQQKTKAVV	PTPN2	96	P17706
NMQEVLIPKLKGWWQ	ANO7	656	Q6IWH7
MDKKLWWADQNLAQL	LRP1B	1786	Q9NZR2
IVIILWRQFWQKMLE	DDR2	416	Q16832
MQWLQKMNKTATKWQ	DST	4526	Q03001
WLWEKQKVMAIVRID	CFAP57	136	Q96MR6
NMINMKIDSWSVWKL	CCDC178	196	Q5BJE1
QQWIKKQMVGRESHW	COLEC12	651	Q5KU26
NMKQIWWAVAPENKV	CSNKA2IP	571	A0A1B0GTH6
AQQVDMWKKYIQWEK	CSTF3	246	Q12996
LENWIWQMVAALKSQ	LIPC	96	P11150
WLYWIDKQQQMIEKI	LRP6	1156	O75581
TAKRRKQQKVWMWNL	MMAA	356	Q8IVH4
KQQKVWMWNLIQESV	MMAA	361	Q8IVH4
IRLVAEKMIWWANKD	GCN1	2566	Q92616
MTKTKDLVWDWQQAA	MROH1	96	Q8NDA8
TMNEKAWKRWCTQIL	NRBP1	171	Q9UHY1
LMDLGANLWVTKLWK	GAL3ST1	401	Q99999
EAIQWMQENWKKSFL	ELOVL6	21	Q9H5J4
WQHTAFQLPMKKIVW	GSTT4	101	A0A1W2PR19
LWIMKNADQSLIRKW	DOCK8	1301	Q8NF50
IVTWLMERKINNWLN	FMO1	251	Q01740
HKLIQLMWNDWNKEV	HEATR4	666	Q86WZ0
EEMWIEQGKLEWKNQ	CCDC144B	276	Q3MJ40
WWKKHMTAIQLIQFV	ELOVL1	196	Q9BW60
HDMIVNVWAWKKNIV	MAPKBP1	156	O60336
KISENWEEKKAWLQM	FAM186A	856	A6NE01
EEMWIEQGKLEWKNQ	CCDC144A	276	A2RUR9
NMKQWNVNWEIKMVT	FERMT2	611	Q96AC1
EVKNAMKQLWSQIIW	OR4C5	306	Q8NGB2
WVWNEVIKNVQMVNK	AK9	1591	Q5TCS8
MKCWQKWEDAQITLL	SNX2	411	O60749
NMEWDKIWAFNKKVI	EPRS1	486	P07814
KLHQMWLSWNQKQLQ	PLIN3	296	O60664
SMEKQSLVWKNTFWQ	NLRP7	126	Q8WX94
NLLQMWLVSQKEWER	MROH2B	891	Q7Z745
KQRSIMKNWQQRWFV	ARHGAP22	46	Q7Z5H3
TQKSVNWLLWAMLII	USE1	226	Q9NZ43
KWQEKMDWLQLVLEV	SPTBN2	2001	O15020
EITKHWDWLEQNIMK	TBC1D8B	86	Q0IIM8
QWLEMLQESGKVTWK	PLEKHD1	126	A6NEE1
LKEASQMNLLARVWW	SGMS1	356	Q86VZ5
QAEVKKMWSRWNLSV	PTH2R	421	P49190
MQWVILKIAWLMQVT	SLC28A1	286	O00337
WKNNGVTKTWDRLML	UPK1B	141	O75841
QHDMVLNVWDWKKDI	WDR62	176	O43379
SKQEKLTGMWWKQLV	SLC25A23	176	Q9BV35
LPWSEQQAQFLWKKM	STRCP1	1161	A6NGW2
QRESKWLDMLNNWDK	TBC1D10A	81	Q9BXI6
QEWEILEKWQKQMYK	ZNF425	21	Q6IV72
LKWEEWKQVWENMLS	WDR87	1516	Q6ZQQ6
LWLQVDWVKSQKIEQ	TRAV6	31	A0A075B6T7
WNIKQMWDTKTLGLR	WDFY1	296	Q8IWB7
MWVWKTLNVMTDLKN	TMEM18	111	Q96B42