Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Sclerotic scapulae	SOST LEMD3	2.71e-05	2	27	2	HP:0001474
HumanPheno	Adult onset	DNHD1 PDCD1 SOST AAAS AUH FDPS NR0B1 GCGR USP9Y COQ2 SLC37A4 HSPB1 PRNP MYORG	4.95e-05	894	27	14	HP:0003581
Domain	MSC	LEMD3 LEMD2	2.05e-05	2	85	2	PF09402
Domain	Inner-Nucl-membr_MAN1	LEMD3 LEMD2	2.05e-05	2	85	2	IPR018996
Domain	LEM	LEMD3 LEMD2	2.03e-04	5	85	2	SM00540
Domain	LEM/LEM-like_dom	LEMD3 LEMD2	4.24e-04	7	85	2	IPR011015
Domain	LEM_dom	LEMD3 LEMD2	4.24e-04	7	85	2	IPR003887
Domain	LEM	LEMD3 LEMD2	4.24e-04	7	85	2	PS50954
Domain	-	LEMD3 LEMD2	4.24e-04	7	85	2	1.10.720.40
Domain	LEM	LEMD3 LEMD2	4.24e-04	7	85	2	PF03020
Domain	Glyco_transf_10	FUT4 FUT7	5.63e-04	8	85	2	PF00852
Domain	Glyco_tran_10_N	FUT4 FUT7	5.63e-04	8	85	2	PF17039
Domain	Glyco_trans_10	FUT4 FUT7	5.63e-04	8	85	2	IPR001503
Domain	Glyco_tran_10_N	FUT4 FUT7	5.63e-04	8	85	2	IPR031481
Pubmed	Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.	FUT4 FUT7	7.38e-06	2	95	2	22359671
Pubmed	α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.	FUT4 FUT7	7.38e-06	2	95	2	23562273
Pubmed	Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.	FUT4 FUT7	7.38e-06	2	95	2	29345354
Pubmed	FUT4 is involved in PD-1-related immunosuppression and leads to worse survival in patients with operable lung adenocarcinoma.	PDCD1 FUT4	7.38e-06	2	95	2	30357521
Pubmed	The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.	FUT4 FUT7	7.38e-06	2	95	2	8752218
Pubmed	Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.	FUT4 FUT7	7.38e-06	2	95	2	31104223
Pubmed	The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.	FUT4 FUT7	7.38e-06	2	95	2	11485743
Pubmed	Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.	FUT4 FUT7	7.38e-06	2	95	2	16709814
Pubmed	Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice.	FUT4 FUT7	7.38e-06	2	95	2	20937846
Pubmed	Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.	FUT4 FUT7	7.38e-06	2	95	2	16394002
Pubmed	Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.	FUT4 FUT7	7.38e-06	2	95	2	16127157
Pubmed	Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.	FUT4 FUT7	7.38e-06	2	95	2	15579466
Pubmed	Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.	FUT4 FUT7	7.38e-06	2	95	2	11535629
Pubmed	Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells.	FUT4 FUT7	7.38e-06	2	95	2	29491007
Pubmed	Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.	FUT4 FUT7	7.38e-06	2	95	2	19608009
Pubmed	Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.	FUT4 FUT7	7.38e-06	2	95	2	12193737
Pubmed	Putative Protein Interactome of the Rhomboid Protease RHBDL4.	AAAS LEMD3 PGAM5	1.56e-05	18	95	3	36857408
Pubmed	Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.	FUT4 FUT7	2.21e-05	3	95	2	23192350
Pubmed	Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.	FUT4 FUT7	2.21e-05	3	95	2	12869507
Pubmed	Melanoma migration is promoted by prion protein via Akt-hsp27 signaling axis.	HSPB1 PRNP	2.21e-05	3	95	2	31870551
Pubmed	A role for leukocyte-endothelial adhesion mechanisms in epilepsy.	FUT4 FUT7	2.21e-05	3	95	2	19029985
Pubmed	Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.	FUT4 FUT7	2.21e-05	3	95	2	15843584
Pubmed	Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.	FUT4 FUT7	2.21e-05	3	95	2	20532047
Pubmed	Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.	FUT4 FUT7	2.21e-05	3	95	2	16352740
Pubmed	T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.	FUT4 FUT7	2.21e-05	3	95	2	16338500
Pubmed	Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH.	FUT4 FUT7	2.21e-05	3	95	2	21982762
Pubmed	Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.	FUT4 FUT7	2.21e-05	3	95	2	15308551
Pubmed	Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.	FUT4 FUT7	2.21e-05	3	95	2	24322980
Pubmed	CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.	FUT4 FUT7	2.21e-05	3	95	2	11278338
Pubmed	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.	FUT4 FUT7	2.21e-05	3	95	2	32341362
Pubmed	α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.	FUT4 FUT7	2.21e-05	3	95	2	23657464
Pubmed	Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.	FUT4 FUT7	2.21e-05	3	95	2	22388819
Pubmed	Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade.	FUT4 FUT7	4.41e-05	4	95	2	27488527
Pubmed	The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.	FUT4 FUT7	4.41e-05	4	95	2	23986452
Pubmed	Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.	FUT4 FUT7	4.41e-05	4	95	2	15059933
Pubmed	Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.	FUT4 FUT7	4.41e-05	4	95	2	18755847
Pubmed	A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.	FUT4 FUT7	4.41e-05	4	95	2	37735247
Pubmed	Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice.	FUT4 FUT7	4.41e-05	4	95	2	22194593
Pubmed	Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.	FUT4 FUT7	4.41e-05	4	95	2	10894166
Pubmed	Notch-dependent control of myelopoiesis is regulated by fucosylation.	FUT4 FUT7	4.41e-05	4	95	2	18359890
Pubmed	Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.	FUT4 FUT7	4.41e-05	4	95	2	22461691
Pubmed	Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis.	FUT4 FUT7	4.41e-05	4	95	2	18056398
Pubmed	Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1.	MDN1 FUT4	7.34e-05	5	95	2	15121843
Pubmed	The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.	FUT4 FUT7	7.34e-05	5	95	2	18037890
Pubmed	N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.	FUT4 FUT7	7.34e-05	5	95	2	16227985
Pubmed	Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.	SH3KBP1 FRS3	7.34e-05	5	95	2	23279575
Pubmed	Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation.	LEMD3 LEMD2	7.34e-05	5	95	2	19720741
Pubmed	Genetic analysis of cholesterol accumulation in inbred mice.	FDPS TG	7.34e-05	5	95	2	11714850
Pubmed	Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing.	FUT4 FUT7	1.10e-04	6	95	2	20929857
Pubmed	Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.	FUT4 FUT7	1.10e-04	6	95	2	20368416
Pubmed	L-selectin mechanochemistry restricts neutrophil priming in vivo.	FUT4 FUT7	1.10e-04	6	95	2	28497779
Pubmed	Regulation of Rev1 by the Fanconi anemia core complex.	FANCE FAAP20	1.10e-04	6	95	2	22266823
Pubmed	Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs.	FUT4 FUT7	1.10e-04	6	95	2	21224079
Pubmed	Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment.	FUT4 FUT7	1.10e-04	6	95	2	21457936
Pubmed	Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.	FUT4 FUT7	1.54e-04	7	95	2	23677475
Pubmed	DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.	FUT4 FUT7	1.54e-04	7	95	2	26070485
Pubmed	Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.	SCO1 COX18	1.54e-04	7	95	2	28330871
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	CPAMD8 MDN1 SMPDL3B FDPS DBNDD2 SH3KBP1 MTARC2 INAVA CHST7 HSPB1 PRNP ALOX15B	2.11e-04	1293	95	12	15342556
Pubmed	Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.	PDPK2P HSPB1	2.62e-04	9	95	2	23979601
Pubmed	Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.	FUT4 FUT7	2.62e-04	9	95	2	15780986
Pubmed	Modularized functions of the Fanconi anemia core complex.	FANCE FAAP20	3.28e-04	10	95	2	24910428
Pubmed	Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects.	FANCE FUT4	3.28e-04	10	95	2	37563658
Pubmed	Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.	FUT4 FUT7	4.00e-04	11	95	2	19303390
Pubmed	The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.	FANCE FAAP20	4.00e-04	11	95	2	19965384
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 MDN1 FAM120C PGAM5 VARS1	4.68e-04	234	95	5	36243803
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FANCE FAAP20	5.65e-04	13	95	2	27986371
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	WNT5B CELSR2	5.65e-04	13	95	2	21246654
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	ABCB10 AUH FDPS SCO1 MTARC2 COX18 MRPL34 COQ2 D2HGDH ME3	5.86e-04	1047	95	10	18614015
Pubmed	The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression.	WNT5B FUT4	6.58e-04	14	95	2	17055474
Pubmed	Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.	FUT4 FUT7	7.57e-04	15	95	2	11698403
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR2 SSPOP	7.57e-04	15	95	2	20473291
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	AAAS AP5B1 TYSND1 PGAM5 HSPB1	8.06e-04	264	95	5	32814769
Pubmed	The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.	FRS3 PDPK2P	8.64e-04	16	95	2	19943849
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	ABCB10 AUH FDPS SCO1 MTARC2 COX18 MRPL34 COQ2 ME3	9.85e-04	926	95	9	20877624
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	AAAS LEMD3 LEMD2	1.03e-03	72	95	3	33106477
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	ABCB10 AUH SCO1 MTARC2 COX18 MRPL34 COQ2 PGAM5 D2HGDH ME3	1.09e-03	1136	95	10	34800366
Pubmed	FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.	FANCE FAAP20	1.10e-03	18	95	2	22343915
Pubmed	Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis.	SOST WFIKKN1	1.22e-03	19	95	2	24131868
Pubmed	Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.	DPP7 NAAA	1.22e-03	19	95	2	29514215
Pubmed	A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.	FANCE FAAP20	1.36e-03	20	95	2	22705371
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EPHB4 LARGE2 NAAA CELSR2 LEMD3 LEMD2 TOR3A SLC37A4 PRNP MYORG	1.65e-03	1201	95	10	35696571
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	FAM120C NYNRIN VSTM2A MYOM3 TMPRSS5 C16orf96 GABBR2	2.52e-03	674	95	7	37196079
Cytoband	16p13.3	WFIKKN1 KREMEN2 C16orf96 PDPK2P PRR25	1.60e-04	244	95	5	16p13.3
GeneFamily	LEM domain containing	LEMD3 LEMD2	2.03e-04	7	57	2	1087
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT4 FUT7	7.45e-04	13	57	2	434
CoexpressionAtlas	ratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#4	DPP7 MYO15B NAAA SMPDL3B SH3KBP1 PRRT4 BAHCC1	1.38e-05	187	89	7	ratio_ECTO_vs_SC_2500_K4
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	C11orf42 WFIKKN1 NR0B1 TMPRSS5 INAVA	1.36e-06	89	95	5	a707477b4aad91817ead162474e9a3c92326f60b
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	C11orf42 WFIKKN1 NR0B1 TMPRSS5 INAVA	1.36e-06	89	95	5	1d2891e2ab271eae6ded2891208bd2bf37a17500
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	C11orf42 WFIKKN1 NR0B1 TMPRSS5 INAVA	1.36e-06	89	95	5	e58b9da18cce5553e18f716c6637fedaaf4858fa
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	C11orf42 WFIKKN1 NR0B1 TMPRSS5 INAVA	1.36e-06	89	95	5	4b807b23f0c315c8293a62278d48c67c9be25a1c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAAA SMPDL3B PTPRCAP TOR3A FUT7 WDFY4	3.04e-06	187	95	6	3d4e81183cb7f6522ae654ddac494662402aa86d
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT5B CELSR2 DBNDD2 CRB3 INAVA HSPB1	4.11e-06	197	95	6	b1c6a15bf6c0645952a7247182dc71baf4736869
ToppCell	368C-Myeloid-Dendritic-cDC1\|368C / Donor, Lineage, Cell class and subclass (all cells)	NAAA SMPDL3B FUT7 WDFY4 CLEC4C	2.25e-05	158	95	5	c276a259e20ee704e2d04baf693e8d677f96f654
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDCD1 PTPRCAP KREMEN2 SH3KBP1 SSPOP	2.32e-05	159	95	5	8d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTARC2 TOR3A WDFY4 VAV2 ALOX15B	2.46e-05	161	95	5	63f0b97c741b610c450f65fa5764d712bfe09ce8
ToppCell	368C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NAAA SMPDL3B FUT7 WDFY4 CLEC4C	2.46e-05	161	95	5	1011094c54381d52566e24c92f89f2efc2aa3eea
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	DBNDD2 CRB3 C16orf96 COX18 ME3	2.61e-05	163	95	5	9f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KCNC1 VSTM2A PRRT4 VAV2 ALOX15B	3.11e-05	169	95	5	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB4 PTPRCAP CHST7 VARS1 HSPB1	3.38e-05	172	95	5	910ec7794ea4000db4ef1e2c34e08dbc0243df2c
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Naive_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LARGE2 PTPRCAP FUT7 WDFY4 CLEC4C	3.67e-05	175	95	5	d544f24ee33783ed4afb4d7ec079a4484118bb15
ToppCell	COVID-19-Myeloid-MoAM4\|COVID-19 / Condition, Lineage and Cell class	EPHB4 NAAA NYNRIN DBNDD2 FRS3	3.87e-05	177	95	5	ca5d0c3d5c700bbe4c2da068eb02be6229afb9a0
ToppCell	Dendritic_Cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	NAAA GCGR FUT7 CCDC88B WDFY4	3.87e-05	177	95	5	d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP CHST7 WDFY4 VARS1 TG	4.20e-05	180	95	5	c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRCAP CHST7 WDFY4 VARS1 TG	4.20e-05	180	95	5	d8135f73a89b97168f2048258f4648e23536ece4
ToppCell	367C-Myeloid-Dendritic-cDC1\|367C / Donor, Lineage, Cell class and subclass (all cells)	NAAA TOR3A FUT7 WDFY4 CLEC4C	4.42e-05	182	95	5	6f5228ac47f9ab46d165740cf2655b5ba217acbe
ToppCell	3'_v3-Lung-Myeloid_Dendritic-DC1\|Lung / Manually curated celltypes from each tissue	NAAA SMPDL3B FUT7 WDFY4 SDK1	4.54e-05	183	95	5	e4cbd39575b5a4612d9934532e3bad63286f8aa5
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-B_cells-Naive_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LARGE2 PTPRCAP PPP1R15A WDFY4 HSPB1	4.66e-05	184	95	5	a068ae741889d59937690c11e0bf405481402c25
ToppCell	367C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PDCD1 NAAA TOR3A WDFY4 CLEC4C	5.03e-05	187	95	5	3748203b62abf51b74dfcfc4f18b3ba831b63a96
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DIPK1C DBNDD2 SH3KBP1 PPP1R15A CHST7	5.03e-05	187	95	5	6820bfbe552ea5e62cfe699687b051a17d9fda61
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LARGE2 MTARC2 TOR3A WDFY4 VAV2	5.29e-05	189	95	5	886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LARGE2 MTARC2 TOR3A WDFY4 VAV2	5.29e-05	189	95	5	5f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LARGE2 MTARC2 TOR3A WDFY4 VAV2	5.43e-05	190	95	5	60bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAAA PPP1R15A FUT7 WDFY4 CLEC4C	5.84e-05	193	95	5	30abf991ac17c18679ab7d633e7549c0ce841920
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LARGE2 PTPRCAP PPP1R15A WDFY4 HSPB1	5.99e-05	194	95	5	d4bbae30b9395139c745b71f8a4a356b11223b69
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LARGE2 SMPDL3B WFIKKN1 CRB3 ZDHHC1	5.99e-05	194	95	5	413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCell	normal_Lung-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	PDCD1 NAAA FUT7 WDFY4 CLEC4C	5.99e-05	194	95	5	d21461682fa755f588afe073abb6a777f339c4cc
ToppCell	distal-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PTPRCAP KREMEN2 FUT7 WDFY4 CLEC4C	6.75e-05	199	95	5	78796b05d28b35e7361b6271d4a3858faa39c45c
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WNT5B GCGR FUT7 CHST7 TG	6.75e-05	199	95	5	82759af613ebfffe037afda55159bf6af812c3ac
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-BMP_responsible_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	EPHB4 WFIKKN1 CAPN6 BTBD17 HSPB1	6.92e-05	200	95	5	ce8a3a8367bafdfabc7c2f96b003aa99526a54e4
Disease	cataract 46 juvenile-onset (implicated_via_orthology)	LEMD3 LEMD2	8.79e-06	2	88	2	DOID:0110243 (implicated_via_orthology)
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	LEMD3 LEMD2	5.69e-04	12	88	2	DOID:11726 (implicated_via_orthology)
Disease	Familial Progressive Myoclonic Epilepsy	KCNC1 PRNP	1.16e-03	17	88	2	C0751777
Disease	Atypical Inclusion-Body Disease	KCNC1 PRNP	1.16e-03	17	88	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	KCNC1 PRNP	1.16e-03	17	88	2	C0751778
Disease	Biotin-Responsive Encephalopathy	KCNC1 PRNP	1.16e-03	17	88	2	C0751780
Disease	May-White Syndrome	KCNC1 PRNP	1.16e-03	17	88	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	KCNC1 PRNP	1.16e-03	17	88	2	C0751781
Disease	Action Myoclonus-Renal Failure Syndrome	KCNC1 PRNP	1.30e-03	18	88	2	C0751779
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	LEMD3 TMPRSS5 INAVA	1.85e-03	81	88	3	EFO_0803334
Disease	progranulin measurement	CELSR2 FAM171A2	1.95e-03	22	88	2	EFO_0004625
Disease	multiple sclerosis	CPAMD8 INAVA CCDC88B LCN6 VAV2 HSPB1 TG	2.01e-03	594	88	7	MONDO_0005301
Disease	QRS duration, response to sulfonylurea	MDN1 COQ2	2.14e-03	23	88	2	EFO_0005055, EFO_0007922
Disease	nephrotic syndrome (implicated_via_orthology)	SH3KBP1 COQ2	2.33e-03	24	88	2	DOID:1184 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WASPGPAWASRRPLQ	nan	6	Q6ZRM9
QWAVPLGRHLGRWSP	CCDC185	171	Q8N715
AFLPARQLWKWSGNP	BAHCC1	2476	Q9P281
PLPWFRGGGVTNLLW	AAAS	281	Q9NRG9
GGRWLRPLPALQLWA	COX18	6	Q8N8Q8
RGLDGPAAWRVWNLN	CCDC88B	81	A6NC98
WRQRPGFAIWAPLPH	C2orf27A	116	P0DPF5
RQPLPTSGRWWLGAA	PRNP	16	F7VJQ1
WGAPWVINNPARDDR	BTBD17	321	A6NE02
LWRQRPGFAIWAPLP	CDRT15P3	121	P0DPF6
LRPARLWGAGPALLW	ABCB10	46	Q9NRK6
AWAGDEAWRRGPAAP	ABCB10	126	Q9NRK6
EAGIWWPRTRFGLPA	CELSR2	1981	Q9HCU4
LIWGFGAHLPSRFWP	DNHD1	2291	Q96M86
WKNHRPWPALGRGFN	LARGE2	241	Q8N3Y3
EPAGGLWSIRPQNGW	INO80	1071	Q9ULG1
RGGDWEPSRIPRLWA	CDKN2A-DT	56	Q9UH64
WVGLWRPHRPRGPIA	ODF3B	6	A8MYP8
WWGARRPAGPELQTP	LEMD3	196	Q9Y2U8
LALAWLPGWRGRSFA	COQ2	16	Q96H96
GGPWEFNLRDLFRWC	MDN1	1941	Q9NU22
APGQAHWLRTGWVPR	EPHB4	66	P54760
RPWFLLGGDERERLW	FAAP20	26	Q6NZ36
ATQGPGLAARRWWAA	LEMD2	151	Q8NC56
QRADPRCWPRGFWSE	IGLJ1	11	A0A0A0MT76
IWPLDPLNGAWFRVE	NAAA	271	Q02083
AGRRAGPAIWAQGWV	AUH	41	Q13825
VLLWWEPFGGRDSAP	FUT4	191	P22083
PAPYWAPRERWLGSL	FDPS	16	P14324
WLIFLANWGGARAEP	SMPDL3B	6	Q92485
QLGWRPGWFLDSPDR	PDCD1	16	Q15116
ARPGPGVWDPNWDRR	PGAM5	51	Q96HS1
APLGPWLRALGPWLR	PEAK3	411	Q6ZS72
PLAQRPRGQPWVWAS	FUT7	106	Q11130
WVRGPRGQPWRDASQ	GCGR	106	P47871
VWLGRLDPEQLLGPW	LCN6	21	P62502
GPRRSWAVWYQQPRG	KREMEN2	411	Q8NCW0
QAFGLPRLPEEWSQW	HSPB1	31	P04792
WLLGWALRGLQGQPP	AP5B1	291	Q2VPB7
WPGWRARQVALGPPC	PDPK2P	351	Q6A1A2
LWTGQLSRGWALLPP	PRR25	296	Q96S07
GWIRQPPGKALEWLA	IGHV2-5	56	P01817
PAWRFDPKSGLWVRN	FAM171A2	251	A8MVW0
AAPEARPGGAWWDRS	NR0B1	161	P51843
WILQSRGLEAPPRGW	MYO15B	676	Q96JP2
LWFLNGLAQGLGWPP	SLC37A4	106	O43826
PDGRPGGFWRRWQPR	KCNC1	161	P48547
RVGSWPLWDLGVLRP	C16orf96	401	A6NNT2
RPEPGAPLLGCWLQW	DBNDD2	56	Q9BQY9
RGAGWRLSPEEPGWN	FRS3	296	O43559
DGPFWWAGLTAQRRR	CPAMD8	656	Q8IZJ3
WGNPNRDRGSWAQPV	FAM120C	551	Q9NX05
RRADSGFWGWLGPLA	C17orf50	86	Q8WW18
RLGLPARPWPRWLGV	MTARC2	11	Q969Z3
ARPWPRWLGVAALGL	MTARC2	16	Q969Z3
LAPWPGRACGALPRW	ME3	11	Q16798
LLLPLAPGAWGWARG	GABBR2	31	O75899
VLRALGSRGWEPFDW	FANCE	46	Q9HB96
GSRGWEPFDWGRLLE	FANCE	51	Q9HB96
RLRNPLGRQEWSGPW	CAPN6	281	Q9Y6Q1
LGPGRRGWWALLALQ	SDK1	76	Q7Z5N4
GGQLWRFLPRGLEFW	SCO1	16	O75880
WPGQTGPEAARLEWR	INAVA	26	Q3KP66
ALGLPFLLARWGRAW	CRB3	11	Q9BUF7
RPDWLLTSFWGGDLR	DPP7	391	Q9UHL4
PLAWPAWLLRGAPGA	D2HGDH	6	Q8N465
RGPRWRGQLASLWAL	DIPK1C	176	Q0P6D2
RAWSRLRGLGPLEPW	PPP1R15A	31	O75807
FGPLWPGAIAATFWR	NYNRIN	356	Q9P2P1
AWFCRWFQLTPPRGG	ALOX15B	86	O15296
DLRLRLWPQGGGWVQ	RXFP4	326	Q8TDU9
RLPALEQGPGGLWVW	VARS1	56	P26640
LGWRLDLPWSGRSGL	SSPOP	51	A2VEC9
LRWPGAQVLWGLSDP	SSPOP	666	A2VEC9
LLWASPPGRWLQARA	PTPRCAP	81	Q14761
WWEGQINGRRGLFPD	SH3KBP1	36	Q96B97
LWALLWPTRAGPGEA	WHAMM	126	Q8TF30
PARLLPNAIGRGKWW	SOST	111	Q9BQB4
EWNWPLLTPRALAAG	SLC23A3	306	Q6PIS1
AWLRDLLFARGAPAW	CHST7	351	Q9NS84
FLGLSDPGGRRHWQW	CLEC4C	141	Q8WTT0
RPLAWRRLVPNFGAW	PAK6-AS1	26	Q8N910
PFWRGPQILSENWLF	C11orf42	281	Q8N5U0
VHWLPRGVLWAGRFP	PEX11G	196	Q96HA9
IQWWFLRGPEDLDPG	VSTM2A	61	Q8TAG5
EWLAPVQGLRAWGRG	REX1BD	61	Q96EN9
EPGASQDALWLWRPR	WDR97	1061	A6NE52
LLPPLWNRTFSWGFD	WDFY4	2896	Q6ZS81
PGRWPWQASVALGFR	TMPRSS5	226	Q9H3S3
TARPKDLPRDWLWGG	WNT5B	146	Q9H1J7
PWWAFQLGLRLGEVG	PRRT4	596	C9JH25
GRWLQPRAWLGFPDA	MRPL34	21	Q9BQ48
PRAWLGFPDAWGLPT	MRPL34	26	Q9BQ48
PNDWRRVDGWPVGLK	USP28	151	Q96RU2
PRGFWKQFRLWGEPV	USP9Y	1666	O00507
IALLLPTAAWGFWPR	TMEM19	321	Q96HH6
LPAVQGPCRGWEPRW	WFIKKN1	361	Q96NZ8
RGDPESPWWEGRLVQ	VAV2	621	P52735
PGSAWAWPGFQRLQE	TOR3A	36	Q9H497
RRFQAPEPLNWTGSW	TG	2241	P01266
PWGLPLRDSGPLWAA	TYSND1	331	Q2T9J0
RAWAAPLWPPRGAGA	ZDHHC1	456	Q8WTX9
LQPRFWGLGWRVEVG	UNQ6493/PRO21345	41	Q6UXR8
GRGPWFWIPLRSHAV	MYOM3	151	Q5VTT5
TGRLPALVRWWNGIG	MYORG	416	Q6NSJ0