Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondinucleotide phosphatase activity

NUDT6 ENPP2

2.55e-049542GO:0004551
GeneOntologyMolecularFunctionS-methyltransferase activity

BHMT2 KMT2A

3.89e-0411542GO:0008172
GeneOntologyMolecularFunctionsignaling adaptor activity

SH2B3 GNB2 YWHAE AXIN1

4.09e-04129544GO:0035591
GeneOntologyMolecularFunctioncalcium channel regulator activity

PACSIN3 GNB2 YWHAE

4.21e-0454543GO:0005246
GeneOntologyMolecularFunctioncalcium channel inhibitor activity

PACSIN3 YWHAE

5.49e-0413542GO:0019855
DomainHaem_d1

WDR19 KMT2A

1.13e-046522IPR011048
DomainC-type_lectin_CS

MRC1 SFTPA2 SFTPA1

2.32e-0443523IPR018378
DomainC_TYPE_LECTIN_1

MRC1 SFTPA2 SFTPA1

1.44e-0380523PS00615
DomainLectin_C

MRC1 SFTPA2 SFTPA1

1.65e-0384523PF00059
DomainCLECT

MRC1 SFTPA2 SFTPA1

1.65e-0384523SM00034
DomainFCH

PACSIN3 PACSIN2

1.69e-0322522PF00611
DomainFCH

PACSIN3 PACSIN2

1.69e-0322522SM00055
DomainC_TYPE_LECTIN_2

MRC1 SFTPA2 SFTPA1

1.71e-0385523PS50041
DomainC-type_lectin-like

MRC1 SFTPA2 SFTPA1

1.77e-0386523IPR001304
DomainFCH_dom

PACSIN3 PACSIN2

1.85e-0323522IPR001060
DomainF_BAR

PACSIN3 PACSIN2

2.19e-0325522IPR031160
DomainF_BAR

PACSIN3 PACSIN2

2.19e-0325522PS51741
DomainAMP-binding_CS

ACSBG1 ACSS3

2.37e-0326522IPR020845
Domain-

MRC1 SFTPA2 SFTPA1

2.50e-03975233.10.100.10
DomainC-type_lectin-like/link

MRC1 SFTPA2 SFTPA1

2.64e-0399523IPR016186
DomainAMP_BINDING

ACSBG1 ACSS3

2.74e-0328522PS00455
DomainAMP-binding

ACSBG1 ACSS3

3.15e-0330522PF00501
DomainAMP-dep_Synth/Lig

ACSBG1 ACSS3

3.15e-0330522IPR000873
DomainCTDL_fold

MRC1 SFTPA2 SFTPA1

3.30e-03107523IPR016187
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

MRC1 LRP12 ENPP2 BDH2 PACSIN3 ATP9A PACSIN2

1.19e-04381427M48063
PathwayREACTOME_SYNTHESIS_OF_KETONE_BODIES

BDH2 ACSS3

2.40e-048422M27718
PathwayREACTOME_DEFECTIVE_CSF2RB_CAUSES_SMDP5

SFTPA2 SFTPA1

2.40e-048422M27575
PathwayREACTOME_SYNTHESIS_OF_KETONE_BODIES

BDH2 ACSS3

2.40e-048422MM15460
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

LRP12 ENPP2 COQ6 GPC4 COQ2

2.90e-04198425M18311
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM

SFTPA2 SFTPA1

3.84e-0410422M27573
PathwayREACTOME_KETONE_BODY_METABOLISM

BDH2 ACSS3

3.84e-0410422MM15437
PathwayREACTOME_KETONE_BODY_METABOLISM

BDH2 ACSS3

3.84e-0410422M27706
PathwayREACTOME_UBIQUINOL_BIOSYNTHESIS

COQ6 COQ2

6.62e-0413422MM17216
PathwayREACTOME_UBIQUINOL_BIOSYNTHESIS

COQ6 COQ2

6.62e-0413422M27142
PathwayREACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS

SFTPA2 SFTPA1

7.71e-0414422MM15011
PathwayWP_RIBOFLAVIN_AND_COQ_DISORDERS

COQ6 COQ2

7.71e-0414422M40065
Pubmed

14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature.

SFTPA2 SFTPA1 YWHAE

2.95e-07954329118970
Pubmed

Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome.

SFTPA2 SFTPA1

2.37e-06254231354704
Pubmed

Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4.

SFTPA2 SFTPA1

2.37e-06254235444643
Pubmed

Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.

SFTPA2 SFTPA1

2.37e-06254210749762
Pubmed

MLL1 is required for maintenance of intestinal stem cells.

KMT2A LGR5

2.37e-06254234860830
Pubmed

The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A.

SFTPA2 SFTPA1

2.37e-06254217593964
Pubmed

Studies of the structure of lung surfactant protein SP-A.

SFTPA2 SFTPA1

2.37e-0625422610270
Pubmed

Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.

SFTPA2 SFTPA1

2.37e-0625429922219
Pubmed

Maternal surfactant protein A influences the immunoprotective properties of milk in a murine model.

SFTPA2 SFTPA1

2.37e-06254224858142
Pubmed

Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus.

SFTPA2 SFTPA1

2.37e-06254211867335
Pubmed

Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure.

SFTPA2 SFTPA1

2.37e-06254219228388
Pubmed

SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.

SFTPA2 SFTPA1

2.37e-06254219494306
Pubmed

An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture.

SFTPA2 SFTPA1

2.37e-06254224793167
Pubmed

Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.

SFTPA2 SFTPA1

2.37e-06254224954098
Pubmed

Characterization of a second human pulmonary surfactant-associated protein SP-A gene.

SFTPA2 SFTPA1

2.37e-0625421372511
Pubmed

Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.

SFTPA2 SFTPA1

2.37e-06254221257967
Pubmed

The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing.

SFTPA2 SFTPA1

2.37e-06254221205009
Pubmed

Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.

SFTPA2 SFTPA1

2.37e-06254238964703
Pubmed

Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants.

SFTPA2 SFTPA1

2.37e-06254234917085
Pubmed

Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.

SFTPA2 SFTPA1

2.37e-06254222219327
Pubmed

Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid.

SFTPA2 SFTPA1

2.37e-06254215890661
Pubmed

Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.

SFTPA2 SFTPA1

2.37e-06254215385504
Pubmed

A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.

SFTPA2 SFTPA1

2.37e-06254223475791
Pubmed

Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference.

SFTPA2 SFTPA1

2.37e-06254223038062
Pubmed

Surfactant protein A binds flagellin enhancing phagocytosis and IL-1β production.

SFTPA2 SFTPA1

2.37e-06254224312669
Pubmed

Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China.

SFTPA2 SFTPA1

2.37e-06254224984162
Pubmed

Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants.

SFTPA2 SFTPA1

2.37e-06254217580966
Pubmed

Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.

SFTPA2 SFTPA1

2.37e-0625423755136
Pubmed

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences.

SFTPA2 SFTPA1

2.37e-06254229394894
Pubmed

Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs.

SFTPA2 SFTPA1

2.37e-06254222384248
Pubmed

The syndapin protein family: linking membrane trafficking with the cytoskeleton.

PACSIN3 PACSIN2

2.37e-06254215226389
Pubmed

Surfactant protein A enhances production of secretory leukoprotease inhibitor and protects it from cleavage by matrix metalloproteinases.

SFTPA2 SFTPA1

2.37e-06254219155504
Pubmed

Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration.

SFTPA2 SFTPA1

2.37e-06254236102297
Pubmed

Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.

SFTPA2 SFTPA1

2.37e-06254217307210
Pubmed

Surfactant protein A modulates induction of regulatory T cells via TGF-β.

SFTPA2 SFTPA1

2.37e-06254222474025
Pubmed

The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.

SFTPA2 SFTPA1

2.37e-06254211504713
Pubmed

Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.

SFTPA2 SFTPA1

2.37e-06254238553537
Pubmed

Further phenotypic heterogeneity of CoQ10 deficiency associated with steroid resistant nephrotic syndrome and novel COQ2 and COQ6 variants.

COQ6 COQ2

2.37e-06254228044327
Pubmed

Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.

SFTPA2 SFTPA1

2.37e-06254233510368
Pubmed

Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function.

SFTPA2 SFTPA1

2.37e-06254219392648
Pubmed

Polymorphisms in the surfactant protein a gene are associated with the susceptibility to recurrent urinary tract infection in chinese women.

SFTPA2 SFTPA1

2.37e-06254220448439
Pubmed

Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products.

SFTPA2 SFTPA1

2.37e-06254220048345
Pubmed

Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer.

SFTPA2 SFTPA1

2.37e-06254232855221
Pubmed

Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages.

SFTPA2 SFTPA1

2.37e-06254211342662
Pubmed

Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.

SFTPA2 SFTPA1

2.37e-0625429126996
Pubmed

Type IV pilus of Pseudomonas aeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-A.

SFTPA2 SFTPA1

2.37e-06254224080545
Pubmed

Lung development in the mouse embryo.

SFTPA2 SFTPA1

2.37e-0625422050021
Pubmed

Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.

SFTPA2 SFTPA1

2.37e-0625421443158
Pubmed

Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates.

SFTPA2 SFTPA1

2.37e-06254227835691
Pubmed

Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.

SFTPA2 SFTPA1

2.37e-06254231350355
Pubmed

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.

SFTPA2 SFTPA1

2.37e-06254223069847
Pubmed

Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences.

SFTPA2 SFTPA1

2.37e-06254219055785
Pubmed

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.

SFTPA2 SFTPA1

2.37e-06254234484180
Pubmed

Surfactant protein A limits Pneumocystis murina infection in immunosuppressed C3H/HeN mice and modulates host response during infection.

SFTPA2 SFTPA1

2.37e-06254215857803
Pubmed

Surfactant protein-A reduces translocation of mediators from the lung into the circulation.

SFTPA2 SFTPA1

2.37e-06254220715984
Pubmed

Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice.

SFTPA2 SFTPA1

2.37e-06254219335775
Pubmed

Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin.

SFTPA2 SFTPA1

2.37e-06254212922979
Pubmed

Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.

SFTPA2 SFTPA1

2.37e-06254218159253
Pubmed

Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.

SFTPA2 SFTPA1

2.37e-06254233141765
Pubmed

Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries.

SFTPA2 SFTPA1

2.37e-06254237256132
Pubmed

Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice.

SFTPA2 SFTPA1

2.37e-06254236871846
Pubmed

Innate immunity of surfactant protein A in experimental otitis media.

SFTPA2 SFTPA1

2.37e-06254231378117
Pubmed

Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.

SFTPA2 SFTPA1

2.37e-06254233267655
Pubmed

Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.

SFTPA2 SFTPA1

2.37e-06254211237812
Pubmed

Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line.

SFTPA2 SFTPA1

2.37e-06254210781424
Pubmed

SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues.

SFTPA2 SFTPA1

2.37e-06254212676766
Pubmed

Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice.

SFTPA2 SFTPA1

2.37e-06254227916681
Pubmed

Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway.

SFTPA2 SFTPA1

2.37e-06254212959932
Pubmed

Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition.

SFTPA2 SFTPA1

2.37e-06254215044702
Pubmed

Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A.

SFTPA2 SFTPA1

2.37e-0625421986781
Pubmed

Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.

SFTPA2 SFTPA1

2.37e-06254212740217
Pubmed

Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse.

SFTPA2 SFTPA1

2.37e-06254218083768
Pubmed

Structural characterisation of human proteinosis surfactant protein A.

SFTPA2 SFTPA1

2.37e-06254211087951
Pubmed

Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses.

SFTPA2 SFTPA1

2.37e-06254216120217
Pubmed

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved.

SFTPA2 SFTPA1

2.37e-06254229202868
Pubmed

The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue.

SFTPA2 SFTPA1

2.37e-06254235322074
Pubmed

Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo.

SFTPA2 SFTPA1

2.37e-06254212060563
Pubmed

Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.

SFTPA2 SFTPA1

2.37e-06254232245819
Pubmed

Characteristics of surfactant from SP-A-deficient mice.

SFTPA2 SFTPA1

2.37e-0625429700084
Pubmed

Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.

SFTPA2 SFTPA1

2.37e-06254222508928
Pubmed

Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population.

SFTPA2 SFTPA1

2.37e-06254220963503
Pubmed

Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene.

SFTPA2 SFTPA1

2.37e-06254220693318
Pubmed

Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection.

SFTPA2 SFTPA1

2.37e-06254211839553
Pubmed

Type IV pilus glycosylation mediates resistance of Pseudomonas aeruginosa to opsonic activities of the pulmonary surfactant protein A.

SFTPA2 SFTPA1

2.37e-06254225605768
Pubmed

Surfactant protein A decreases lung injury and mortality after murine marrow transplantation.

SFTPA2 SFTPA1

2.37e-06254212204891
Pubmed

Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice.

SFTPA2 SFTPA1

2.37e-06254212959946
Pubmed

Surfactant protein-A enhances ureaplasmacidal activity in vitro.

SFTPA2 SFTPA1

2.37e-06254220197455
Pubmed

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

SFTPA2 SFTPA1 PCK1

3.37e-06195437628695
Pubmed

The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.

SFTPA2 SFTPA1

7.09e-06354212015304
Pubmed

Surfactant proteins SP-A and SP-D: structure, function and receptors.

SFTPA2 SFTPA1

7.09e-06354216213021
Pubmed

Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.

SFTPA2 SFTPA1

7.09e-06354216330552
Pubmed

Macrophage-independent fungicidal action of the pulmonary collectins.

SFTPA2 SFTPA1

7.09e-06354212857753
Pubmed

Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.

SFTPA2 SFTPA1

7.09e-06354220810986
Pubmed

Altered surfactant function and structure in SP-A gene targeted mice.

SFTPA2 SFTPA1

7.09e-0635428790375
Pubmed

Disruption of the SP-A/SP-R210L (MYO18Aα) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.

SFTPA2 SFTPA1

7.09e-06354238349123
Pubmed

Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection.

SFTPA2 SFTPA1

7.09e-06354216917077
Pubmed

Surfactant protein A (SP-A) gene targeted mice.

SFTPA2 SFTPA1

7.09e-0635429813377
Pubmed

The concentration of surfactant protein-A in amniotic fluid decreases in spontaneous human parturition at term.

SFTPA2 SFTPA1

7.09e-06354218828058
Pubmed

Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D.

SFTPA2 SFTPA1

7.09e-06354215588319
Pubmed

Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema.

SFTPA2 SFTPA1

7.09e-06354212376353
Cytoband10q22.3

SFTPA2 SFTPA1

1.19e-034354210q22.3
CytobandEnsembl 112 genes in cytogenetic band chr20q13

SRSF6 ATP9A PCK1 B4GALT5

1.55e-03422544chr20q13
Cytoband19p13.2

ZNF823 TIMM29 ZNF442

2.52e-0322954319p13.2
GeneFamilyCollectins

SFTPA2 SFTPA1

1.92e-0410382491
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

PACSIN3 PACSIN2

1.06e-03233821288
GeneFamilyAcyl-CoA synthetase family

ACSBG1 ACSS3

1.35e-032638240
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SFTPA2 SFTPA1

3.35e-03413821298
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 MRC1 LRP12 UBE2T TRIM36

1.51e-061615458937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCelldroplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 BHMT2 BDH2 PCK1 B4GALT5

1.87e-06168545dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF420 UBASH3A ZZEF1 HEATR3

3.21e-0514954441f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ENPP2 TSNARE1 ZNF208 ACSS3

3.94e-05157544f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ENPP2 TSNARE1 ZNF208 ACSS3

3.94e-0515754443a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCellBAL-Severe-cDC_4|Severe / Compartment, Disease Groups and Clusters

MRC1 SFTPA2 ACSBG1 ZNF165

4.04e-0515854473f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BHMT2 BDH2 PCK1 B4GALT5

4.89e-051665448ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 LRP12 TRIM36 CLSTN1

5.13e-0516854404e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCelldroplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BHMT2 BDH2 PCK1 B4GALT5

5.49e-0517154405fcc72df50a380a913821b5781d9621df37d328
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BHMT2 BDH2 PCK1 B4GALT5

5.49e-0517154448fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP2 GPC4 BDH2 B4GALT5

5.88e-05174544eb8012823b08729b462d1e5212f4873bb6b4eb1e
ToppCell10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages|bone_marrow / Manually curated celltypes from each tissue

MRC1 SH2B3 ENPP2 HEATR3

5.88e-051745440746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP2 GPC4 BDH2 B4GALT5

5.88e-0517454432fdeeebeeeca657eac6329caad4c28ca54e4d1c
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SFTPA2 LHFPL3 SFTPA1 ACSS3

6.70e-05180544198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 GPC4 PACSIN3 ATP9A

7.00e-05182544770ce9f3f4538d0181a0181543841bc964c68274
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 GPC4 PACSIN3 ATP9A

7.00e-0518254477ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 GPC4 PACSIN3 ATP9A

7.00e-051825444921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SFTPA2 LHFPL3 SFTPA1 ACSS3

7.15e-051835446847c1252d6bb105524f812658112517fd351eab
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRUNE2 MRC1 LRP12 UBE2T

7.45e-0518554457c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF420 UBASH3A ZZEF1 HEATR3

7.61e-0518654474c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 LHFPL3 BHMT2 CLSTN1

7.77e-05187544c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PRUNE2 ENPP2 BHMT2 PCK1

7.77e-05187544acd305475f3609800af0d7bc68d83ef41228080b
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF420 UBASH3A ZZEF1 HEATR3

7.77e-05187544816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

SFTPA2 LHFPL3 SFTPA1 ACSS3

8.10e-05189544dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 LHFPL3 BHMT2 CLSTN1

8.26e-051905441cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

SFTPA2 LHFPL3 SFTPA1 ACSS3

8.43e-05191544a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

SFTPA2 GPC4 SFTPA1 ACSS3

8.60e-0519254406013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFTPA2 LHFPL3 SFTPA1 ACSS3

8.78e-05193544fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFTPA2 LHFPL3 SFTPA1 ACSS3

8.78e-05193544f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell(01)_Cycling_Basal_(homeostasis)-(1)_24hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

PRUNE2 NUDT6 KIAA1958

8.82e-05715436aa56b0daaeb5e0ae30619f9c6945c8e42899b27
ToppCellControl-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

SFTPA2 LHFPL3 SFTPA1 PACSIN2

8.95e-05194544a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 GPC4 BDH2 LGR5

9.13e-051955443f64e2313ec79a6d5f4013a52722d071172f6c5d
ToppCellmild-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF823 MTA1 CDC27 ZZEF1

9.13e-051955441e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP2 GPC4 BDH2 LGR5

9.13e-051955447a5108335353ac160b684650c5da97d6f7f4dbcf
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 BHMT2 BDH2 PCK1

9.32e-051965444ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell(05)_Secretory-(0)_Reference|(05)_Secretory / shred by cell type by condition

PKD1L1 YWHAE HEATR3 ACSS3

9.32e-051965447cb79cf122852c971f2d6e8d1e2b26eade891e83
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 LHFPL3 BHMT2 CLSTN1

9.50e-051975445a71e859ebe734fc70a056807b07d99fa867c687
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SFTPA2 LHFPL3 SFTPA1 ACSS3

9.69e-051985442e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 BHMT2 BDH2 PCK1

9.69e-0519854472733b6149b797ac11cc108bc80428b77fbbba78
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 BHMT2 BDH2 PCK1

9.69e-05198544f23559ce6072e3c323f6791ff95269271b0f7ff1
ToppCellTransverse-(5)_Dendritic_cell-(51)_cDC1|Transverse / shred on region, Cell_type, and subtype

SH2B3 GPC4 KIAA1958 ACSS3

9.88e-0519954452dd1c4cd372f8ee515307a9200e357bb2145888
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SFTPA2 SFTPA1 GNB2 COQ2

9.88e-051995448f2fff877ca53226f1f5be02c234b911dd29fb20
ToppCellTransverse-Dendritic_cell-cDC1|Transverse / Region, Cell class and subclass

SH2B3 GPC4 KIAA1958 ACSS3

9.88e-05199544b68419939d206417158a703f60a374bf8ec5d5a1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Astrocyte|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ACSBG1 LHFPL3 BDH2 TMEM132B

1.01e-042005447205e742ad796d548761839d92a4794ee8f17629
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

UBE2T ZNF208 TRIM36 TMEM132B

1.01e-04200544fd6b4ff4330db11c03f1eb4e06b43a162326f744
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Astrocyte|GW26 / Sample Type, Dataset, Time_group, and Cell type.

ACSBG1 GPC4 BDH2 TMEM132B

1.01e-04200544158ba898312c73bcb54c675a4860874a1dd58662
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SH2B3 ENPP2 KMT2A B4GALT5

1.01e-042005442d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 BHMT2 BDH2 PCK1

1.01e-04200544234e5a927eec0e235226586451ba3754c8a14169
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 BHMT2 BDH2 PCK1

1.01e-04200544e118d5e6e5d5bb808877a6667668c36f21afad5b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

ACSBG1 LHFPL3 BDH2 TMEM132B

1.01e-0420054425b573f4427ecafe050ca90bea459f1b25b451cf
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ENPP2 LDOC1 LGR5

1.01e-04200544829978708463a7459fe1041bd90196775bc4b531
ComputationalSignaling.

MRC1 GPC4 KMT2A LDOC1 PCK1 CNR2 B4GALT5

5.48e-06219357MODULE_129
DiseaseHuntington's disease (implicated_via_orthology)

PACSIN3 PACSIN2 CNR2

2.33e-0532513DOID:12858 (implicated_via_orthology)
Diseaselevel of leukocyte immunoglobulin-like receptor subfamily B member 4 in blood serum

SFTPA2 SFTPA1

2.92e-055512OBA_2042200
Diseaselevel of prosaposin in blood serum

SFTPA2 SFTPA1

2.92e-055512OBA_2044552
Diseasenewborn respiratory distress syndrome (biomarker_via_orthology)

SFTPA2 SFTPA1

4.37e-056512DOID:12716 (biomarker_via_orthology)
Diseasenewborn respiratory distress syndrome (is_implicated_in)

SFTPA2 SFTPA1

6.12e-057512DOID:12716 (is_implicated_in)
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 4 measurement

SFTPA2 SFTPA1

8.15e-058512EFO_0801768
Diseasemyelofibrosis (is_implicated_in)

SH2B3 KMT2A

8.15e-058512DOID:4971 (is_implicated_in)
Diseasecomplement C1q tumor necrosis factor-related protein 1 measurement

SFTPA2 SFTPA1

1.91e-0412512EFO_0801493
Diseasegranulins measurement

SFTPA2 SFTPA1

1.91e-0412512EFO_0008141
DiseaseLeukemia, Myelocytic, Acute

UBE2T SH2B3 KMT2A CNR2

2.30e-04173514C0023467
DiseaseHamman-Rich syndrome

SFTPA2 SFTPA1

2.63e-0414512C0085786
Diseasebacterial pneumonia (biomarker_via_orthology)

SFTPA2 SFTPA1

2.63e-0414512DOID:874 (biomarker_via_orthology)
DiseaseFamilial Idiopathic Pulmonary Fibrosis

SFTPA2 SFTPA1

5.46e-0420512C4721952
DiseaseIdiopathic Pulmonary Fibrosis

SFTPA2 SFTPA1

6.02e-0421512C1800706
Diseasenephrotic syndrome (implicated_via_orthology)

COQ6 COQ2

7.89e-0424512DOID:1184 (implicated_via_orthology)
Diseasecongenital diaphragmatic hernia (biomarker_via_orthology)

SFTPA2 SFTPA1

7.89e-0424512DOID:3827 (biomarker_via_orthology)
DiseaseAcute monocytic leukemia

UBE2T KMT2A

9.27e-0426512C0023465
DiseaseMiller Dieker syndrome

UBE2T YWHAE

1.15e-0329512C0265219
Diseaseunipolar depression, bipolar disorder, seasonality measurement

SFTPA2 SFTPA1

1.24e-0330512EFO_0003761, EFO_0006876, MONDO_0004985
Diseaselung disease (biomarker_via_orthology)

SFTPA2 SFTPA1

1.68e-0335512DOID:850 (biomarker_via_orthology)
Diseaselung cancer (is_marker_for)

SRSF6 AXIN1

2.08e-0339512DOID:1324 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
WTSDMQGDGEEQNKE

YWHAE

231

P62258
WDACSEALIMFDKDN

COQ6

121

Q9Y2Z9
RDQDTGKENEMDWDD

CLSTN1

891

O94985
VGFQEAMKDLDWDCL

B4GALT5

216

O43286
MEECWVTEIANGSKD

CNR2

1

P34972
ECVGDDIAWMKFDAQ

PCK1

306

P35558
KGLDVCNWTDGDEMQ

PAN2

821

Q504Q3
GCTINDMWDQDYDKK

COQ2

126

Q96H96
EAWKCNNMDECGDSS

LRP12

181

Q9Y561
GMDIQKSENEDDSEW

LTV1

176

Q96GA3
FLDEMKQCFGWDDDE

LDOC1

121

O95751
EMGWQEDSENDETCA

GPBP1

391

Q86WP2
ERMAAGNGNEDDCWN

GPC4

411

O75487
GWDLDDNNDKSDCLA

GABRQ

531

Q9UN88
CEWMDLNDLAKTENT

NUDT6

246

P53370
DFNCNIWDAMKGDRA

GNB2

291

P62879
NDWLEEECGNMAREG

ATP9A

581

O75110
DELTKMEDEDEQGWC

PACSIN2

451

Q9UNF0
MEDEDEQGWCKGRLD

PACSIN2

456

Q9UNF0
VNMCCNEDPSDDEWE

HEATR3

371

Q7Z4Q2
DNMESKWEDVNAAAC

BHMT2

81

Q9H2M3
LNEDEEWKCDQDMDE

AXIN1

241

O15169
EWKCDQDMDEDDGRD

AXIN1

246

O15169
NMEDKTCEAIDEEGW

ACSBG1

531

Q96GR2
KEDCEAENVWEMGGL

KMT2A

1406

Q03164
ISCKASQDIDDDMNW

IGKV5-2

41

P06315
DMDKNSPEAWCAAGN

CDC27

561

P30260
VNWNDELSLQAMCED

PKD1L1

906

Q8TDX9
CNSSEDESKWVEELM

ENPP2

806

Q13822
LDKGDLENIWDCSMV

LGR5

751

O75473
LKMSEEDEQGWCQGQ

PACSIN3

391

Q9UKS6
NEAGKWMDDTCDSKR

MRC1

1061

P22897
NRDDEMSWNEIEVCG

TRIM36

456

Q9NQ86
DMDNDLDWDDCSGGA

PRUNE2

1131

Q8WUY3
GAWMRDCDINDDEFL

TIMM29

176

Q9BSF4
FDSDDNIKWVCQDMG

TMEM132B

1046

Q14DG7
NCVAMDWDKDGDVLA

WDR19

56

Q8NEZ3
KEQCVEMYTDGQWND

SFTPA2

221

Q8IWL1
CSWQDLKDFMRQAGE

SRSF6

121

Q13247
CRDEMEEWSASEANL

MTA1

281

Q13330
KEQCVEMYTDGQWND

SFTPA1

221

Q8IWL2
LDCEEKDWDFSMNLN

BDH2

91

Q9BUT1
LDWDEEMAKAQSHDC

ACSS3

271

Q9H6R3
DCIEMKWEDQNIGDQ

ZNF823

41

P16415
LADDEKVFNGSDNMW

TSNARE1

386

Q96NA8
QDEGKWDNCLSEDMA

SPATA46

121

Q5T0L3
GITCWQDKDQMDDLR

UBE2T

21

Q9NPD8
DEQQLNSWMAELSEC

SH2B3

291

Q9UQQ2
DCIGMKWEDTNIEDQ

ZNF442

66

Q9H7R0
EECGKAFNWSSNLME

ZNF208

696

O43345
WDCDNESENSRSMPK

ZNF165

181

P49910
EEDELADAKQNSEWM

ZZEF1

1726

O43149
ADAKQNSEWMDECQD

ZZEF1

1731

O43149
ELSQWEMSDRLENCD

ZNF420

66

Q8TAQ5
GMCFCEENKEEGKWE

UBASH3A

621

P57075
SDEEEMWQAGCLGDD

KIAA1958

536

Q8N8K9
DGWDSDEVKRMCGEK

LHFPL3

161

Q86UP9