Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein K29-linked ubiquitination	UBE2D2 UBE2D3 UBE2D4	7.97e-06	13	64	3	GO:0035519
GeneOntologyBiologicalProcess	protein K27-linked ubiquitination	UBE2D2 UBE2D3 UBE2D4	1.01e-05	14	64	3	GO:0044314
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SOX3 HOXB3 TCF3 UBE2D3 ZNF608 SUPT5H CHD5 TBX21 ZBTB5 ASXL2 ARID1A EP300 MEIS2	1.72e-05	1053	64	13	GO:0000122
GeneOntologyBiologicalProcess	protein K6-linked ubiquitination	UBE2D2 UBE2D3 UBE2D4	1.88e-05	17	64	3	GO:0085020
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX3 HOXB3 TCF3 UBE2D3 ZNF608 GCLC SUPT5H CHD5 TBX21 ZBTB5 ASXL2 ARID1A EP300 MEIS2	7.89e-05	1399	64	14	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX3 HOXB3 TCF3 UBE2D3 ZNF608 GCLC SUPT5H CHD5 TBX21 ZBTB5 ASXL2 ARID1A EP300 MEIS2	8.78e-05	1413	64	14	GO:1902679
GeneOntologyBiologicalProcess	B cell lineage commitment	TCF3 PRKDC	1.41e-04	6	64	2	GO:0002326
GeneOntologyBiologicalProcess	regulation of lymphocyte differentiation	ABL1 ZNF608 TBX21 PRKDC ARID1A EP300	1.74e-04	266	64	6	GO:0045619
GeneOntologyBiologicalProcess	T cell differentiation	TCF3 ABL1 ZNF608 TBX21 PRKDC ARID1A EP300	1.77e-04	382	64	7	GO:0030217
GeneOntologyBiologicalProcess	protein K11-linked ubiquitination	UBE2D2 UBE2D3 UBE2D4	2.05e-04	37	64	3	GO:0070979
GeneOntologyBiologicalProcess	regulation of hemopoiesis	ABL1 ZNF608 TBX21 ASXL2 PRKDC ARID1A EP300 MEIS2	2.56e-04	540	64	8	GO:1903706
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	EBF2 SOX3 TET2 HOXB3 TCF3 ABL1 SUPT5H TBX21 PLAG1 ASXL2 PRKDC EP300 MEIS2	2.90e-04	1390	64	13	GO:0045944
GeneOntologyBiologicalProcess	T cell lineage commitment	TBX21 PRKDC EP300	3.00e-04	42	64	3	GO:0002360
GeneOntologyBiologicalProcess	signal transduction by p53 class mediator	SETD9 PDK2 CHD5 PPP1R13B EP300	3.16e-04	191	64	5	GO:0072331
GeneOntologyBiologicalProcess	hemopoiesis	TET2 HOXB3 TCF3 ABL1 ZNF608 TBX21 DACT2 ASXL2 PRKDC ARID1A EP300 MEIS2	3.33e-04	1223	64	12	GO:0030097
GeneOntologyBiologicalProcess	regulation of leukocyte differentiation	ABL1 ZNF608 TBX21 ASXL2 PRKDC ARID1A EP300	3.59e-04	429	64	7	GO:1902105
GeneOntologyBiologicalProcess	hematopoietic progenitor cell differentiation	TET2 HOXB3 ABL1 DACT2 PRKDC	3.65e-04	197	64	5	GO:0002244
GeneOntologyBiologicalProcess	immunoglobulin V(D)J recombination	TCF3 PRKDC	4.20e-04	10	64	2	GO:0033152
GeneOntologyBiologicalProcess	T cell differentiation in thymus	TCF3 ABL1 ZNF608 PRKDC	4.36e-04	114	64	4	GO:0033077
Domain	Tensin_PTB	TNS1 TNS3	6.48e-05	4	62	2	IPR033929
Domain	UBQ-conjugating_AS	UBE2D2 UBE2D3 UBE2D4	7.61e-05	25	62	3	IPR023313
Domain	UQ_con	UBE2D2 UBE2D3 UBE2D4	2.92e-04	39	62	3	PF00179
Domain	PTEN_C2	TNS1 TNS3	3.00e-04	8	62	2	SM01326
Domain	PTEN_C2	TNS1 TNS3	3.00e-04	8	62	2	PF10409
Domain	PTB	TNS1 TNS3	3.00e-04	8	62	2	PF08416
Domain	PTB	TNS1 TNS3	3.00e-04	8	62	2	IPR013625
Domain	C2_TENSIN	TNS1 TNS3	3.00e-04	8	62	2	PS51182
Domain	Tensin_lipid_phosphatase_dom	TNS1 TNS3	3.00e-04	8	62	2	IPR029023
Domain	Tensin_C2-dom	TNS1 TNS3	3.00e-04	8	62	2	IPR014020
Domain	UBIQUITIN_CONJUGAT_1	UBE2D2 UBE2D3 UBE2D4	3.15e-04	40	62	3	PS00183
Domain	UBQ-conjugat_E2	UBE2D2 UBE2D3 UBE2D4	3.39e-04	41	62	3	IPR000608
Domain	UBIQUITIN_CONJUGAT_2	UBE2D2 UBE2D3 UBE2D4	3.39e-04	41	62	3	PS50127
Domain	PPASE_TENSIN	TNS1 TNS3	3.85e-04	9	62	2	PS51181
Domain	-	UBE2D2 UBE2D3 UBE2D4	6.48e-04	51	62	3	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2D2 UBE2D3 UBE2D4	7.25e-04	53	62	3	IPR016135
Domain	FYVE	HGS FGD5	4.16e-03	29	62	2	PF01363
Domain	FYVE	HGS FGD5	4.16e-03	29	62	2	SM00064
Domain	SH2	ABL1 TNS1 TNS3	4.61e-03	101	62	3	PF00017
Domain	Znf_FYVE-rel	HGS FGD5	5.68e-03	34	62	2	IPR017455
Domain	SH2	ABL1 TNS1 TNS3	5.84e-03	110	62	3	SM00252
Domain	SH2	ABL1 TNS1 TNS3	5.99e-03	111	62	3	PS50001
Domain	SH2	ABL1 TNS1 TNS3	6.14e-03	112	62	3	IPR000980
Domain	-	ABL1 TNS1 TNS3	6.14e-03	112	62	3	3.30.505.10
Pubmed	The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.	UBE2D2 UBE2D3 UBE2D4	2.17e-07	7	65	3	21685362
Pubmed	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	UBE2D2 UBE2D3 UBE2D4	2.17e-07	7	65	3	30884854
Pubmed	Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.	UBE2D2 UBE2D3 UBE2D4	3.47e-07	8	65	3	28681414
Pubmed	Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.	UBE2D2 UBE2D3 UBE2D4	3.47e-07	8	65	3	23560854
Pubmed	Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.	UBE2D2 UBE2D3 UBE2D4	3.47e-07	8	65	3	29323787
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	SEL1L SUPT5H ACBD5 BACE1 ERLEC1 EP300	3.90e-07	150	65	6	32423001
Pubmed	Bag1 directly routes immature BCR-ABL for proteasomal degradation.	ABL1 UBE2D2 UBE2D3	7.41e-07	10	65	3	20675402
Pubmed	Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.	UBE2D2 UBE2D3 UBE2D4	7.41e-07	10	65	3	31087003
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	UBE2D2 UBE2D3 UBE2D4	7.41e-07	10	65	3	28757353
Pubmed	Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.	UBE2D2 UBE2D3 UBE2D4 HGS	7.82e-07	38	65	4	35331737
Pubmed	The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.	UBE2D2 UBE2D3 UBE2D4	1.35e-06	12	65	3	24211586
Pubmed	Ubiquitination of STING at lysine 224 controls IRF3 activation.	UBE2D2 UBE2D3 UBE2D4	1.76e-06	13	65	3	28763789
Pubmed	Human transcription factor protein interaction networks.	TET2 TCF3 ZNF608 ATAD3A CHD5 HGS SEC24B PPP1R13B PUM2 LSM14A ASXL2 ARID1A EP300	2.02e-06	1429	65	13	35140242
Pubmed	Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.	UBE2D2 UBE2D3 UBE2D4	2.23e-06	14	65	3	36481767
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ABL1 FAM168B PLAG1 PRKDC ARID1A EP300 TNS3	2.94e-06	332	65	7	37433992
Pubmed	Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.	UBE2D2 UBE2D4	3.44e-06	2	65	2	26912277
Pubmed	Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.	TNS1 TNS3	3.44e-06	2	65	2	35954177
Pubmed	Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis.	CHD5 ARID1A	3.44e-06	2	65	2	22910690
Pubmed	c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.	ABL1 EP300	3.44e-06	2	65	2	16648821
Pubmed	Further characterization of the juxtaglomerular neurons in the mouse main olfactory bulb by transcription factors, Sp8 and Tbx21.	SP8 TBX21	3.44e-06	2	65	2	22387948
Pubmed	Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.	TBX21 PRKDC	3.44e-06	2	65	2	16861655
Pubmed	BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.	ABL1 PRKDC	3.44e-06	2	65	2	19697154
Pubmed	The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus Entry.	ABL1 TMPRSS2	3.44e-06	2	65	2	37896901
Pubmed	Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates.	TBX21 ARID1A	3.44e-06	2	65	2	37315534
Pubmed	Functional interaction between DNA-PK and c-Abl in response to DNA damage.	ABL1 PRKDC	3.44e-06	2	65	2	9109492
Pubmed	Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.	UBE2D2 UBE2D3 UBE2D4	4.16e-06	17	65	3	33650289
Pubmed	Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.	UBE2D2 UBE2D3 UBE2D4	4.16e-06	17	65	3	36563856
Pubmed	Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.	UBE2D2 UBE2D3 UBE2D4	5.91e-06	19	65	3	27425610
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TET2 TCF3 ZNF608 PUM2 EP300	9.98e-06	152	65	5	38360978
Pubmed	c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.	ABL1 BACE1	1.03e-05	3	65	2	27565738
Pubmed	FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.	FKBP10 PRKDC	1.03e-05	3	65	2	32187554
Pubmed	E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.	TCF3 EP300	1.03e-05	3	65	2	22544934
Pubmed	E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300.	TCF3 EP300	1.03e-05	3	65	2	22387215
Pubmed	Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions.	TBX21 FGD5	1.03e-05	3	65	2	35348580
Pubmed	Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease.	BACE1 EP300	1.03e-05	3	65	2	25051175
Pubmed	Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.	TCF3 EP300	1.03e-05	3	65	2	10545951
Pubmed	Identification of a family of closely related human ubiquitin conjugating enzymes.	UBE2D2 UBE2D3	1.03e-05	3	65	2	8530467
Pubmed	Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.	TCF3 EP300	1.03e-05	3	65	2	32098872
Pubmed	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.	UBE2D2 UBE2D3	1.03e-05	3	65	2	30095198
Pubmed	Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.	UBE2D2 UBE2D3	1.03e-05	3	65	2	11912157
Pubmed	c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.	ABL1 TBX21	1.03e-05	3	65	2	21690296
Pubmed	The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.	UBE2D2 UBE2D3 UBE2D4	1.07e-05	23	65	3	30017913
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ATAD3A TBX21 PUM2 PRKDC ARID1A EP300 MEIS2	1.18e-05	411	65	7	35182466
Pubmed	Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.	UBE2D2 UBE2D3 UBE2D4	1.23e-05	24	65	3	24647965
Pubmed	Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.	UBE2D2 UBE2D3 UBE2D4	1.23e-05	24	65	3	34195792
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	TCF3 SLC30A5 PDK2 SEC24B PRKDC EP300	1.32e-05	276	65	6	28319085
Pubmed	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.	UBE2D2 UBE2D3 UBE2D4	1.57e-05	26	65	3	20061386
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	UBE2D2 UBE2D3 UBE2D4	1.76e-05	27	65	3	21143188
Pubmed	Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.	UBE2D2 UBE2D3 UBE2D4	1.76e-05	27	65	3	30097011
Pubmed	Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells.	ABL1 EP300	2.06e-05	4	65	2	16636310
Pubmed	Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.	TCF3 EP300	2.06e-05	4	65	2	22207202
Pubmed	Early thymocyte development is regulated by modulation of E2A protein activity.	TCF3 PRKDC	2.06e-05	4	65	2	11560990
Pubmed	Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.	UBE2D2 UBE2D3	2.06e-05	4	65	2	9535861
Pubmed	Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.	UBE2D2 UBE2D3	2.06e-05	4	65	2	20696396
Pubmed	ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.	ARID1A EP300	2.06e-05	4	65	2	33176148
Pubmed	Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.	SP8 TBX21	2.06e-05	4	65	2	27603780
Pubmed	SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.	UBE2D2 BACE1	2.06e-05	4	65	2	20854419
Pubmed	Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.	TNS1 TNS3	2.06e-05	4	65	2	19194507
Pubmed	Physical and functional interactions between ZIP kinase and UbcH5.	UBE2D2 UBE2D3	2.06e-05	4	65	2	18515077
Pubmed	FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.	ABL1 EP300	2.06e-05	4	65	2	25911675
Pubmed	The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.	UBE2D2 UBE2D3	2.06e-05	4	65	2	31241013
Pubmed	Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.	UBE2D3 HGS	2.06e-05	4	65	2	12230472
Pubmed	Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.	TCF3 EP300	2.06e-05	4	65	2	12435739
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	MYO15B DRD5 UBE2D2 UBE2D3 UBE2D4 HGS HSFX1 TMPRSS2	2.26e-05	630	65	8	36949045
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SEL1L FKBP10 SLC30A5 ATAD3A SEC24B ACBD5 DHRS1	2.71e-05	468	65	7	31056421
Pubmed	Inactivation of tensin3 in mice results in growth retardation and postnatal lethality.	TNS1 TNS3	3.43e-05	5	65	2	15733665
Pubmed	The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.	TNS1 TNS3	3.43e-05	5	65	2	17190795
Pubmed	E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).	UBE2D2 UBE2D3	3.43e-05	5	65	2	15684077
Pubmed	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	UBE2D2 UBE2D3	3.43e-05	5	65	2	26502057
Pubmed	Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.	TET2 PRKDC	3.43e-05	5	65	2	34848557
Pubmed	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.	PPP1R13B EP300	3.43e-05	5	65	2	21513714
Pubmed	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.	UBE2D2 UBE2D3	3.43e-05	5	65	2	10329681
Pubmed	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	UBE2D2 UBE2D3	3.43e-05	5	65	2	25327252
Pubmed	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.	UBE2D2 UBE2D3	3.43e-05	5	65	2	14562029
Pubmed	Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.	UBE2D2 UBE2D3	3.43e-05	5	65	2	23408431
Pubmed	Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.	UBE2D2 UBE2D3	3.43e-05	5	65	2	19741096
Pubmed	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.	UBE2D2 UBE2D3	3.43e-05	5	65	2	8090726
Pubmed	Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit.	ABL1 PRKDC	3.43e-05	5	65	2	9312071
Pubmed	ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.	UBE2D2 UBE2D3	3.43e-05	5	65	2	16413270
Pubmed	Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.	TCF3 EP300	3.43e-05	5	65	2	19828133
Pubmed	Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.	TCF3 EP300	3.43e-05	5	65	2	14752053
Pubmed	The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.	UBE2D2 UBE2D3	3.43e-05	5	65	2	31929179
Pubmed	Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.	UBE2D2 HGS	3.43e-05	5	65	2	18508924
Pubmed	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.	UBE2D2 UBE2D3	3.43e-05	5	65	2	23509263
Pubmed	Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.	TCF3 TBX21	3.43e-05	5	65	2	23536629
Pubmed	Hgs physically interacts with Smad5 and attenuates BMP signaling.	HGS EP300	3.43e-05	5	65	2	16516194
Pubmed	Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.	SEL1L ERLEC1	3.43e-05	5	65	2	23356641
Pubmed	DNA damage activates p53 through a phosphorylation-acetylation cascade.	PRKDC EP300	3.43e-05	5	65	2	9744860
Pubmed	A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.	UBE2D2 UBE2D3	3.43e-05	5	65	2	18313049
Pubmed	An AUTS2-Polycomb complex activates gene expression in the CNS.	UBE2D3 ZNF608 EP300	5.02e-05	38	65	3	25519132
Pubmed	Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.	UBE2D3 EP300	5.13e-05	6	65	2	24167073
Pubmed	Cell fate decisions by c-Myc depend on ZBTB5 and p53.	ZBTB5 EP300	5.13e-05	6	65	2	33051058
Pubmed	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.	UBE2D2 UBE2D3	5.13e-05	6	65	2	22124327
Pubmed	h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.	UBE2D2 UBE2D3	5.13e-05	6	65	2	16549277
Pubmed	The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.	UBE2D2 UBE2D3	5.13e-05	6	65	2	25701873
Pubmed	Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.	UBE2D2 UBE2D3	5.13e-05	6	65	2	22976837
Pubmed	Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.	UBE2D3 PRKDC	5.13e-05	6	65	2	28415827
Pubmed	p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.	ABL1 TNS1	5.13e-05	6	65	2	8810278
Pubmed	Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.	UBE2D2 UBE2D3	5.13e-05	6	65	2	30404641
Pubmed	Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	5.13e-05	6	65	2	9990509
Interaction	CRX interactions	SOX3 TET2 MYO15B ZNF608 HGS PRKAB2 ASXL2 ARID1A EP300	1.20e-07	254	65	9	int:CRX
Interaction	TLX3 interactions	TET2 FAM168B ZNF608 ATAD3A TBX21 LSM14A ARID1A EP300 RSKR	3.80e-07	291	65	9	int:TLX3
Interaction	TRIM10 interactions	UBE2D2 UBE2D3 UBE2D4 HGS PRKAB2	4.59e-07	48	65	5	int:TRIM10
Interaction	FOXI1 interactions	FAM168B ZNF608 HGS ASXL2 ARID1A EP300	5.10e-07	92	65	6	int:FOXI1
Interaction	EYA4 interactions	TET2 TCF3 UBE2D2 ZNF608 SUPT5H SEC24B PUM2 EP300	1.11e-06	243	65	8	int:EYA4
Interaction	SUB1 interactions	TET2 TCF3 ABL1 SUPT5H CHD5 PRKDC EP300 ITFG1	1.26e-06	247	65	8	int:SUB1
Interaction	CNOT4 interactions	UBE2D2 UBE2D3 UBE2D4 LSM14A EP300	2.12e-06	65	65	5	int:CNOT4
Interaction	MEX3A interactions	ABL1 UBE2D2 FAM168B PLAG1 LSM14A PRKDC ARID1A EP300 TNS3	3.76e-06	384	65	9	int:MEX3A
Interaction	TRIM17 interactions	UBE2D2 UBE2D3 UBE2D4 HGS	4.25e-06	34	65	4	int:TRIM17
Interaction	DTX1 interactions	UBE2D2 UBE2D3 UBE2D4 EP300	4.79e-06	35	65	4	int:DTX1
Interaction	SOX15 interactions	ZNF608 ATAD3A CHD5 LSM14A ARID1A EP300	6.20e-06	141	65	6	int:SOX15
Interaction	ARK2C interactions	UBE2D2 UBE2D3 UBE2D4	6.90e-06	12	65	3	int:ARK2C
Interaction	RNF43 interactions	UBE2D2 UBE2D3 UBE2D4 ATAD3A CHD5 HGS SEC24B PPP1R13B ARID1A	8.85e-06	427	65	9	int:RNF43
Interaction	SEC31A interactions	TCF3 SLC30A5 SEC24B TRMT1 TMPRSS2 LSM14A EP300	1.08e-05	236	65	7	int:SEC31A
Interaction	RNF14 interactions	TCF3 UBE2D2 UBE2D3 UBE2D4	1.87e-05	49	65	4	int:RNF14
Interaction	B4GALT3 interactions	SEL1L TCF3 SEC24B ERLEC1 EP300	2.35e-05	106	65	5	int:B4GALT3
Interaction	RNF150 interactions	UBE2D2 UBE2D3 UBE2D4	3.51e-05	20	65	3	int:RNF150
Interaction	KLF5 interactions	TET2 ZNF608 ATAD3A LSM14A ARID1A EP300	3.91e-05	195	65	6	int:KLF5
Interaction	EDEM1 interactions	SEL1L SUPT5H ACBD5 BACE1 ERLEC1 EP300	4.75e-05	202	65	6	int:EDEM1
Interaction	UBOX5 interactions	UBE2D2 UBE2D3 UBE2D4	5.42e-05	23	65	3	int:UBOX5
Interaction	DTX3L interactions	UBE2D2 UBE2D3 UBE2D4 HGS	6.87e-05	68	65	4	int:DTX3L
Interaction	RTRAF interactions	TCF3 FGD5 ASXL2 PRKDC EP300 ITFG1	8.02e-05	222	65	6	int:RTRAF
Interaction	ERG interactions	TET2 ZNF608 ASXL2 PRKDC ARID1A EP300	8.22e-05	223	65	6	int:ERG
Interaction	SAR1A interactions	LRIG3 TCF3 SLC30A5 SEC24B ACBD5 PRKDC EP300	8.30e-05	325	65	7	int:SAR1A
Interaction	RTF2 interactions	ABL1 UBE2D2 TRMT1 EP300	1.01e-04	75	65	4	int:RTF2
Interaction	RNF103 interactions	UBE2D2 UBE2D3 UBE2D4	1.10e-04	29	65	3	int:RNF103
Interaction	STAM2 interactions	UBE2D2 UBE2D3 HGS PPP1R13B TMPRSS2	1.12e-04	147	65	5	int:STAM2
Interaction	CADPS2 interactions	UBE2D2 UBE2D3 UBE2D4	1.22e-04	30	65	3	int:CADPS2
Interaction	IGF1R interactions	SEL1L FKBP10 SEC24B TMPRSS2 FGD5 PRKDC ERLEC1 EP300	1.24e-04	467	65	8	int:IGF1R
Interaction	TERF1 interactions	ARPP21 ABL1 SUPT5H TRMT1 PRKDC KLHDC4 EP300	1.25e-04	347	65	7	int:TERF1
Interaction	TRIM3 interactions	UBE2D2 UBE2D3 UBE2D4 HGS	1.30e-04	80	65	4	int:TRIM3
Interaction	SOX7 interactions	TET2 ZNF608 ARID1A EP300	1.43e-04	82	65	4	int:SOX7
Interaction	TRIM62 interactions	UBE2D2 UBE2D3 UBE2D4	1.49e-04	32	65	3	int:TRIM62
Interaction	BIRC8 interactions	UBE2D2 UBE2D3 UBE2D4	1.49e-04	32	65	3	int:BIRC8
Interaction	MEX3C interactions	UBE2D2 UBE2D3 ATAD3A PRKDC	1.57e-04	84	65	4	int:MEX3C
Interaction	TRIM45 interactions	UBE2D2 UBE2D3 UBE2D4	1.63e-04	33	65	3	int:TRIM45
Interaction	TMEM129 interactions	SEL1L UBE2D3 SLC30A5	1.63e-04	33	65	3	int:TMEM129
Interaction	KLF4 interactions	MYO15B ATAD3A HGS ARID1A EP300	1.67e-04	160	65	5	int:KLF4
Interaction	SP1 interactions	ATAD3A TBX21 ZBTB5 PRKDC EP300 MEIS2 ITFG1	1.70e-04	365	65	7	int:SP1
Interaction	PAX6 interactions	SOX3 ZNF608 HGS ASXL2 ARID1A EP300 MEIS2	1.73e-04	366	65	7	int:PAX6
Interaction	PCNA interactions	TCF3 ABL1 UBE2D3 FGD5 ASXL2 PRKDC EP300 ITFG1	1.90e-04	497	65	8	int:PCNA
Interaction	ZNRF1 interactions	UBE2D2 UBE2D3 UBE2D4	2.12e-04	36	65	3	int:ZNRF1
Interaction	MOV10 interactions	MBTPS1 SUPT5H HGS ACBD5 BACE1 PPP1R13B PUM2 LSM14A GIT2 ARID1A KLHDC4 EP300 TNS3	2.17e-04	1297	65	13	int:MOV10
Interaction	UVSSA interactions	UBE2D2 UBE2D3 UBE2D4	2.30e-04	37	65	3	int:UVSSA
Interaction	MKRN2 interactions	UBE2D2 UBE2D4 PUM2 PLAG1 LSM14A EP300 ITFG1	2.36e-04	385	65	7	int:MKRN2
Interaction	TLX1 interactions	ZNF608 ASXL2 ARID1A EP300 MEIS2	2.53e-04	175	65	5	int:TLX1
Interaction	C2orf42 interactions	PRKAB2 PPP1R13B	2.83e-04	8	65	2	int:C2orf42
Interaction	UBTD1 interactions	UBE2D2 UBE2D3 UBE2D4	2.91e-04	40	65	3	int:UBTD1
Interaction	ALG13 interactions	ZNF608 PUM2 LSM14A ARID1A EP300	3.11e-04	183	65	5	int:ALG13
Interaction	DZIP3 interactions	UBE2D2 UBE2D3 UBE2D4 GIT2 PRKDC	3.11e-04	183	65	5	int:DZIP3
Interaction	TRIM35 interactions	UBE2D2 UBE2D3 UBE2D4 PRKAB2	3.43e-04	103	65	4	int:TRIM35
Interaction	SIAH2 interactions	UBE2D2 UBE2D3 PPP1R13B EP300	3.56e-04	104	65	4	int:SIAH2
Interaction	ALDH18A1 interactions	FKBP10 DPYD TCF3 ASXL2 EP300	3.60e-04	189	65	5	int:ALDH18A1
Interaction	RNF25 interactions	UBE2D2 UBE2D3 UBE2D4	3.60e-04	43	65	3	int:RNF25
Interaction	MARCHF3 interactions	UBE2D2 UBE2D3 UBE2D4	3.60e-04	43	65	3	int:MARCHF3
Interaction	CFAP68 interactions	MYO15B HGS PRKAB2	3.60e-04	43	65	3	int:CFAP68
Interaction	HOXB3 interactions	HOXB3 EP300	3.63e-04	9	65	2	int:HOXB3
Interaction	SCT interactions	HGS MEIS2	3.63e-04	9	65	2	int:SCT
Interaction	TRAPPC12 interactions	TCF3 SLC30A5 SEC24B RSKR	3.69e-04	105	65	4	int:TRAPPC12
Interaction	MDM4 interactions	ABL1 UBE2D2 UBE2D3 EP300	3.69e-04	105	65	4	int:MDM4
Interaction	HNF1B interactions	TET2 ZNF608 ASXL2 ARID1A EP300	3.69e-04	190	65	5	int:HNF1B
Interaction	DTX3 interactions	UBE2D2 UBE2D3 UBE2D4 PRKDC	4.11e-04	108	65	4	int:DTX3
Interaction	MESP1 interactions	TCF3 EP300	4.53e-04	10	65	2	int:MESP1
Interaction	PAX8 interactions	TET2 ZNF608 ARID1A EP300	4.56e-04	111	65	4	int:PAX8
Interaction	EP300 interactions	HOXB3 TCF3 ABL1 SLC30A5 SUPT5H TBX21 SEC24B TRMT1 ZBTB5 PPP1R13B PRKDC ARID1A EP300	4.58e-04	1401	65	13	int:EP300
Interaction	NFKB1 interactions	UBE2D2 UBE2D3 ATAD3A HGS ACBD5 EP300	4.62e-04	307	65	6	int:NFKB1
Interaction	TRIM38 interactions	UBE2D2 UBE2D3 UBE2D4	4.69e-04	47	65	3	int:TRIM38
Interaction	ZNRF2 interactions	UBE2D2 UBE2D3 UBE2D4	4.69e-04	47	65	3	int:ZNRF2
Interaction	TBR1 interactions	TET2 ZNF608 ARID1A EP300	4.88e-04	113	65	4	int:TBR1
Interaction	BFAR interactions	UBE2D2 UBE2D3 UBE2D4	4.99e-04	48	65	3	int:BFAR
Interaction	RABGEF1 interactions	TCF3 UBE2D3 SLC30A5 GIT2 EP300	5.11e-04	204	65	5	int:RABGEF1
Interaction	TRIM50 interactions	UBE2D2 UBE2D3 UBE2D4	5.31e-04	49	65	3	int:TRIM50
Interaction	RMND5B interactions	UBE2D2 UBE2D3 UBE2D4	5.31e-04	49	65	3	int:RMND5B
Interaction	TRIM54 interactions	MYO15B UBE2D2 UBE2D3 UBE2D4 HGS PRKAB2	5.84e-04	321	65	6	int:TRIM54
Interaction	ERBB2 interactions	LRIG3 ABL1 ATAD3A SEC24B PPP1R13B PRKDC TNS1 TNS3	5.91e-04	589	65	8	int:ERBB2
Interaction	CARM1 interactions	TCF3 SUPT5H SEC24B ASXL2 ARID1A EP300	6.24e-04	325	65	6	int:CARM1
Interaction	NPRL2 interactions	TCF3 ATAD3A ZBTB5 EP300	6.31e-04	121	65	4	int:NPRL2
Interaction	RNF216 interactions	UBE2D2 UBE2D3 UBE2D4	6.32e-04	52	65	3	int:RNF216
Interaction	TRAPPC2L interactions	TCF3 SLC30A5 SEC24B EP300	6.51e-04	122	65	4	int:TRAPPC2L
Interaction	EPHB2 interactions	ABL1 HGS SEC24B PPP1R13B PRKDC	6.62e-04	216	65	5	int:EPHB2
Interaction	DAO interactions	PRKAB2 EP300	6.62e-04	12	65	2	int:DAO
Interaction	TRIM43 interactions	UBE2D2 UBE2D3 UBE2D4	6.69e-04	53	65	3	int:TRIM43
Interaction	TRIM2 interactions	UBE2D2 UBE2D3 UBE2D4	6.69e-04	53	65	3	int:TRIM2
Interaction	RNF125 interactions	UBE2D2 UBE2D3 UBE2D4	6.69e-04	53	65	3	int:RNF125
Interaction	RNF167 interactions	UBE2D2 UBE2D3 UBE2D4	7.06e-04	54	65	3	int:RNF167
Interaction	EEF1D interactions	MBTPS1 SUPT5H FGD5 ASXL2 EP300 ITFG1	7.08e-04	333	65	6	int:EEF1D
Interaction	RNF138 interactions	UBE2D2 UBE2D4 ARID1A ITFG1	7.13e-04	125	65	4	int:RNF138
Interaction	EPS15 interactions	ABL1 UBE2D2 UBE2D3 HGS ACBD5	7.19e-04	220	65	5	int:EPS15
Interaction	CIITA interactions	TCF3 ATAD3A EP300	7.45e-04	55	65	3	int:CIITA
Interaction	TMPRSS2 interactions	ABL1 HGS SEC24B TMPRSS2 PRKDC ERLEC1	7.53e-04	337	65	6	int:TMPRSS2
Interaction	DCAF1 interactions	TET2 UBE2D2 UBE2D3 TMPRSS2 PRKDC	7.79e-04	224	65	5	int:DCAF1
Interaction	RNF34 interactions	UBE2D2 UBE2D3 SUPT5H	7.86e-04	56	65	3	int:RNF34
Interaction	MYLIP interactions	UBE2D2 UBE2D3 UBE2D4	7.86e-04	56	65	3	int:MYLIP
Interaction	PAX9 interactions	ZNF608 TBX21 ARID1A EP300	8.26e-04	130	65	4	int:PAX9
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2D2 UBE2D3 UBE2D4	7.97e-05	41	37	3	102
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	TNS1 TNS3	1.13e-04	8	37	2	837
GeneFamily	SH2 domain containing	ABL1 TNS1 TNS3	1.15e-03	101	37	3	741
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	HGS FGD5	1.83e-03	31	37	2	81
Disease	colorectal cancer (is_marker_for)	TET2 TCF3 ABL1 GCLC ARID1A	2.19e-05	157	63	5	DOID:9256 (is_marker_for)
Disease	Burkitt Lymphoma	TCF3 ABL1 ARID1A	6.30e-05	36	63	3	C0006413
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	TCF3 ABL1 EP300	3.06e-04	61	63	3	C1961102
Disease	Colorectal Neoplasms	TET2 DPYD CHD5 ARID1A EP300	3.17e-04	277	63	5	C0009404
Disease	Burkitt Leukemia	TCF3 ARID1A	4.63e-04	15	63	2	C4721444
Disease	African Burkitt's lymphoma	TCF3 ARID1A	4.63e-04	15	63	2	C0343640
Disease	T-Cell Lymphoma	ARID1A EP300	5.28e-04	16	63	2	C0079772
Disease	prostate carcinoma	EBF2 TET2 SP8 GCLC PPP1R13B TMPRSS2 PLAG1 TNS3	5.97e-04	891	63	8	EFO_0001663
Disease	Colorectal Carcinoma	TET2 DPYD TCF3 CHD5 ARID1A CSMD3 EP300	7.30e-04	702	63	7	C0009402
Disease	Precursor B-cell lymphoblastic leukemia	TCF3 ABL1	9.18e-04	21	63	2	C1292769
Disease	risk-taking behaviour	TET2 DPYD ARPP21 ZNF608 PPP1R13B ERLEC1 EP300	1.19e-03	764	63	7	EFO_0008579
Disease	Adenoid Cystic Carcinoma	PRKDC ARID1A EP300	1.29e-03	100	63	3	C0010606
Disease	Sezary Syndrome	TET2 ARID1A	1.52e-03	27	63	2	C0036920
Disease	diverticular disease	SP8 HOXB3 TBX21 TNS1	1.64e-03	236	63	4	EFO_0009959
Disease	large artery stroke	DPYD MBTPS1 FGD5	1.84e-03	113	63	3	EFO_0005524
Disease	monocyte count	TET2 TCF3 ZNF608 GCLC PLAG1 PRKDC LCT LMNTD1 TNS3	1.87e-03	1320	63	9	EFO_0005091
Disease	neutrophil percentage of leukocytes	TET2 TRMT1 PRKDC ARID1A LCT ERLEC1	1.91e-03	610	63	6	EFO_0007990
Disease	Prostatic Neoplasms	TET2 MBTPS1 ATAD3A TMPRSS2 PRKDC ARID1A	2.00e-03	616	63	6	C0033578
Disease	Malignant neoplasm of prostate	TET2 MBTPS1 ATAD3A TMPRSS2 PRKDC ARID1A	2.00e-03	616	63	6	C0376358

Protein segments in the cluster

Peptide	Gene	Start	Entry
IEGQMTPYYPVGMGN	ERLEC1	181	Q96DZ1
TPYYPVGMGNGTPCS	ERLEC1	186	Q96DZ1
QYPNPGMGSAGNLLT	EP300	206	Q09472
SGQGYYVEMTVGSPP	BACE1	71	P56817
NITAMNGTIYSPGYP	CSMD3	2286	Q7Z407
PGGIVNYNQMPLGPY	CHD5	1936	Q8TDI0
PLYPGMLYVPFGANQ	AMBN	236	Q9NP70
GPFQYYLGGHSSQPM	ACBD5	331	Q5T8D3
SLYRNILMYGPPGTG	ATAD3A	391	Q9NVI7
GYSNVPMANLGVPGS	EBF2	481	Q9HAK2
LSSSPPGPYGQEMYA	PRKAB2	181	O43741
SGPMYGPGQSSFLNI	DPYD	596	Q12882
YETGSGQKPYLPMGE	GIT2	516	Q14161
NTLAGGMEGTPFYQP	PPP1R13B	731	Q96KQ4
QAGQGSLPATGMPVY	ARPP21	751	Q9UBL0
LYGSPTQIGPSYRGM	ASXL2	1316	Q76L83
MLPPGSNGTAYPGQF	DRD5	1	P21918
ATGMPGYQVLAPTAY	PUM2	426	Q8TB72
AMGGLSYTQQIPPYG	ARID1A	441	O14497
GEMYSVPYSTGQGQP	ARID1A	1386	O14497
CSQPIYYGGMPTVVN	MBTPS1	501	Q14703
TGPMYLKGNVYGSDP	LRIG3	926	Q6UXM1
PAGLQSMPGDYVSQG	MEIS2	381	O14770
LANPYVMGVGLPGQA	FGD5	426	Q6ZNL6
PGQPYGGTMSEFNTV	GCLC	106	P48506
TLQYMAPEVLSGGPY	RSKR	266	Q96LW2
MSYAGYGTGQHPPGI	LCT	546	P09848
SSGMPLGYYLSSPQI	LMNTD1	41	Q8N9Z9
QSMGSYGPFGRMPTY	LSM14A	106	Q8ND56
YMYSTAPTPQPGTGG	PDK2	306	Q15119
AIGPTQQGYPMVYPG	MYO15B	811	Q96JP2
YIGQGYIIPGMDQGL	FKBP10	316	Q96AY3
QGYMPLEGPQQSGSL	DACT2	406	Q5SW24
YYGNLMVGGTPHNIL	GLT6D1	226	Q7Z4J2
ESFIPTGPGQNYMVG	CFAP70	181	Q5T0N1
TGPGQNYMVGLQVPS	CFAP70	186	Q5T0N1
YGTPTMQGSPVYVGG	HOXB3	341	P14651
GMSPYPGIDLSQVYE	ABL1	436	P00519
MSVTPQGGIVVYGGY	KLHDC4	236	Q8TBB5
YFGGLPPGQYATRMT	LINC00526	21	Q96FQ7
SPGSLQYMFNVPYGV	DHRS1	151	Q96LJ7
VSYPSLPAGDTYGQM	SEC24B	196	O95487
MNPVYSPGSSGVPYA	FAM168B	1	A1KXE4
MYPGANPTFQTGYTP	FAM168B	41	A1KXE4
LYVPGSPTQMNSYGP	HSFX1	321	Q9UBD0
GLQYSPMMPPGAQSY	SOX3	306	P41225
LPNTAAMENGTGPYG	TRMT1	31	Q9NXH9
NPVGQSGLGMAYLYG	SEL1L	446	Q9UBV2
PKGAVVSMYPGTVYQ	SETD9	146	Q8NE22
GRTPMYGSQTPMYGS	SUPT5H	766	O00267
AMQPVYTSGIYNVGP	TNS3	206	Q68CZ2
GLQGIYPRVGMAHPY	SP8	171	Q8IXZ3
PGIIFIPGYLSYMNG	ABHD10	76	Q9NUJ1
PYNPLSVGSLGMSYS	PLAG1	431	Q6DJT9
SLNMTGSGIYAPNGP	VNN2	271	O95498
TIMGPNDSPYQGGVF	UBE2D2	36	P62837
MIGSPRGGASNFPYY	ZBTB5	521	O15062
MALNSGSPPAIGPYY	TMPRSS2	1	O15393
GPLSPSGMKGTSQYY	TCF3	136	P15923
EPMVNGGGYPYESAS	TNS1	551	Q9HBL0
QAMPAAGGVLYQPSG	HGS	571	O14964
TIMGPNDSPYQGGVF	UBE2D3	36	P61077
GGQGAPPMYQLYKRT	PRKDC	951	P78527
THVGMGYPLIPGQYD	ZNF608	1466	Q9ULD9
GYSPEGTPLYNFMGD	SLC30A5	376	Q8TAD4
TIMGPNDSPYQGGVF	UBE2D4	36	Q9Y2X8
GVNQPGPYIMYTTVD	ITFG1	461	Q8TB96
TGNSNMPGGLPRQAY	TET2	606	Q6N021
SAPGPTMSYYRGQEV	TBX21	411	Q9UL17